| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yumin Wei, Liping Zhang, Chao Wang, Zefeng Li, Mingjie Luo, Guomin Xie, Xingjiu Yang, Mengyuan Li, Shuyue Ren, Dongbing Zhao, Ran Gao, Jia-Nan Gon. Anti-apoptotic protein BCL-XL as a therapeutic vulnerability in gastric cancer. Animal models and experimental medicine. 2023-06-05. PMID:37271936. |
evasion of programmed cell death (apoptosis) is a hallmark of cancer cells and direct induction of apoptosis by targeting the pro-survival bcl2 family proteins represents a promising therapeutic strategy for cancer treatment. |
2023-06-05 |
2023-08-14 |
Not clear |
| Md Rafi Uz Zama Khan, Emiko Yanase, Vishal Trived. Extraction, phytochemical characterization and anti-cancer mechanism of Haritaki churna: An ayurvedic formulation. PloS one. vol 18. issue 5. 2023-06-01. PMID:37256897. |
cancer cells exhibiting dna fragmentation, changes in expression of several apoptotic proteins such as bcl2, cytochrome-c and formation of cleaved products of caspase 3 and parp-1 suggests ellagic acid induces cell death via mitochondrial pathway of apoptosis. |
2023-06-01 |
2023-08-14 |
human |
| Jian-Fei Wu, Yu Liu, San-Ni Gong, Xiang-Dong Zi, You-Guo Ta. Effects of vascular endothelial growth factor (VEGF) on the viability, apoptosis and steroidogenesis of yak (Bos grunniens) granulosa cells. Theriogenology. vol 207. 2023-05-28. PMID:37245256. |
this treatment significantly reduced gc apoptosis (p < 0.05) by promoting the expression of bcl2 and gdf9 (p < 0.01) and inhibiting the expression of bax and caspase3 (p < 0.05). |
2023-05-28 |
2023-08-14 |
Not clear |
| Fulong Nan, Wenlong Nan, Zhongjie Yu, Hui Wang, Xiaoni Cui, Shasha Jiang, Xianjuan Zhang, Jun Li, Zhifei Wang, Shuyun Zhang, Bin Wang, Yiquan L. Polygalacin D inhibits the growth of hepatocellular carcinoma cells through BNIP3L-mediated mitophagy and endogenous apoptosis pathways. Chinese journal of natural medicines. vol 21. issue 5. 2023-05-28. PMID:37245873. |
in addition, further analysis of autophagy showed that pgd induced mitophagy by increasing bcl2 interacting protein 3 like (bnip3l) levels.in vivo experiments demonstrated that pgd significantly inhibited tumor growth and increased the levels of apoptosis and autophagy in tumors. |
2023-05-28 |
2023-08-14 |
Not clear |
| Mamdoh S Moawadh, Rashid Mir, Faris J Tayeb, Orooba Asim, Mohammad Fahad Ulla. Molecular Evaluation of the Impact of Polymorphic Variants in Apoptotic ( Current issues in molecular biology. vol 45. issue 5. 2023-05-26. PMID:37232720. |
molecular evaluation of the impact of polymorphic variants in apoptotic ( the regulation of apoptosis (the programmed cell death) is dependent on the crucial involvement of bcl2 and bax. |
2023-05-26 |
2023-08-14 |
Not clear |
| Xueping Ke, Shicheng Yu, Shubiao Situ, Zhenqian Lin, Yiqiang Yua. Morroniside inhibits Beclin1-dependent autophagic death and Bax-dependent apoptosis in cardiomyocytes through repressing BCL2 phosphorylation. In vitro cellular & developmental biology. Animal. 2023-05-08. PMID:37155079. |
morroniside inhibits beclin1-dependent autophagic death and bax-dependent apoptosis in cardiomyocytes through repressing bcl2 phosphorylation. |
2023-05-08 |
2023-08-14 |
rat |
| Xueping Ke, Shicheng Yu, Shubiao Situ, Zhenqian Lin, Yiqiang Yua. Morroniside inhibits Beclin1-dependent autophagic death and Bax-dependent apoptosis in cardiomyocytes through repressing BCL2 phosphorylation. In vitro cellular & developmental biology. Animal. 2023-05-08. PMID:37155079. |
finally, the significance of bcl2 or jnk in morroniside-regulated autophagy, apoptosis, and proliferation in h9c2 cells was assessed by combining morroniside and bcl2 competitive inhibitor (abt-737) or jnk activator (anisomycin). |
2023-05-08 |
2023-08-14 |
rat |
| Xueping Ke, Shicheng Yu, Shubiao Situ, Zhenqian Lin, Yiqiang Yua. Morroniside inhibits Beclin1-dependent autophagic death and Bax-dependent apoptosis in cardiomyocytes through repressing BCL2 phosphorylation. In vitro cellular & developmental biology. Animal. 2023-05-08. PMID:37155079. |
overall, morroniside inhibits beclin1-dependent autophagic death and bax-dependent apoptosis via jnk-mediated bcl2 phosphorylation, thereby improving the survival of cardiomyocytes under hypoxia. |
2023-05-08 |
2023-08-14 |
rat |
| Fatemeh Hosseini, Masoumeh Mirzaei Chegeni, Ali Bidaki, Mohammad Zaer, Hossein Abolhassani, Seyed Arsalan Seyedi, Seyed Ali Nabipoorashrafi, Arezoo Ashrafnia Menarbazari, Alaa Moeinzadeh, Ahmad Reza Farmani, Mohammad Tavakkoli Yarak. 3D-printing-assisted synthesis of paclitaxel-loaded niosomes functionalized by cross-linked gelatin/alginate composite: Large-scale synthesis and in-vitro anti-cancer evaluation. International journal of biological macromolecules. 2023-05-08. PMID:37156313. |
the anticancer effect of the designed nanocarrier could be attributed to gene expression regulation, where a significant increase in the expression and activity of genes promoting apoptosis (casp-3, casp-8, and casp-9) and inhibiting metastasis (bax, and p53) and a remarkable decrease in metastasis-enhancing genes (bcl2, mmp-2, and mmp-9) were observed. |
2023-05-08 |
2023-08-14 |
Not clear |
| Jianqiu Han, Chen Zhao, Huixia Guo, Tengfei Liu, Yongmei Li, Yalei Qi, Jan M Deussing, Yanjia Zhang, Juan Tan, Honghui Han, Xueyun M. Obesity induces male mice infertility via oxidative stress, apoptosis and glycolysis. Reproduction (Cambridge, England). 2023-05-04. PMID:37140983. |
our study also found that the expression of cleaved caspase-3 (cc3) and b-cell lymphoma-2 (bcl2) showed an obesity severity-dependent manner indicating that apoptosis is highly correlated with male infertility caused by obesity. |
2023-05-04 |
2023-08-14 |
mouse |
| Zhijing Zhang, Lideng Guo, Fei Yang, Shanpan Peng, Di Wang, Xiawei Lai, Baiqin Su, Haihui Xi. Adiponectin Attenuates Splenectomy-Induced Cognitive Deficits by Neuroinflammation and Oxidative Stress via TLR4/MyD88/NF-κb Signaling Pathway in Aged Rats. ACS chemical neuroscience. 2023-05-04. PMID:37141577. |
further experiments indicated that apn could inhibit the toll-like receptor 4 (tlr4)/myeloid differentiation factor 88 (myd88)/nuclear factor kappa b (nf-κb) p65 pathway to decrease the degree of oxidative damage (malondialdehyde (mda) and superoxide dismutase (sod)), microglia-mediated neuroinflammation (ionized calcium binding adapter molecule 1 (iba1), caspase-1, tumor necrosis factor (tnf)-α, interleukin-1β (il-1β), and interleukin-6 (il-6)), and apoptosis (p53, bcl2, bax, and caspase 3) in hippocampus. |
2023-05-04 |
2023-08-14 |
rat |
| Tianli Shen, Shuanying Yang, Xiaoyan Qu, Zilu Chen, Lizhong Zeng, Xuejun Sun, Yuyao Lin, Meng Luo, Bo Lei, Chenyang Yue, Chunhong Ma, Nan Hu, Wei Wang, Long Zhan. A bionic "Trojan horse"-like gene delivery system hybridized with tumor and macrophage cell membrane for cancer therapy. Journal of controlled release : official journal of the Controlled Release Society. 2023-04-30. PMID:37121518. |
m@nps/mir21 can deliver mir21 antagomir into mc38 cancer cells and tumor tissues, promote tumor apoptosis, and regulate the expression of bcl2 and ki67. |
2023-04-30 |
2023-08-14 |
Not clear |
| Dan Shan, Xin Wen, Xiaoju Guan, Hangping Fang, Yijia Liu, Mengjie Qin, Hu Wang, Jingfeng Xu, Jieqiang Lv, Junzhao Zhao, Haolin Che. Pubertal lead exposure affects ovary development, folliculogenesis and steroidogenesis by activation of IRE1α-JNK signaling pathway in rat. Ecotoxicology and environmental safety. vol 257. 2023-04-22. PMID:37086621. |
such activation may also result in apoptosis since the death-signaling molecules chop and cleaved-casp3 were up-regulated while bcl2 was down-regulated. |
2023-04-22 |
2023-08-14 |
rat |
| Zhanhang Wang, Yonglong He, Shujuan Liu, Xiaolong Xu, Yuxuan Song, Lei Zhang, Xiaopeng A. Toxic effects of zinc oxide nanoparticles as a food additive in goat mammary epithelial cells. Food research international (Ottawa, Ont.). vol 167. 2023-04-22. PMID:37087259. |
moreover, the expression levels of bax, cytc, caspase 3 and caspase 9 were upregulated, while the expression levels of bcl2 were downregulated, which indicated mitochondria-mediated intrinsic apoptosis pathway was activated. |
2023-04-22 |
2023-08-14 |
Not clear |
| Chao Li, Jingwen Wang, Jun Feng, Gaoliang Zhou, Yongjin Jiang, Chunmiao Luo, Ziping Cheng, Jiehua L. Circ-JA760602 promotes the apoptosis of hypoxia-induced cardiomyocytes through transcriptionally suppressing BCL2. The International journal of developmental biology. 2023-04-20. PMID:37078361. |
circ-ja760602 promotes the apoptosis of hypoxia-induced cardiomyocytes through transcriptionally suppressing bcl2. |
2023-04-20 |
2023-08-14 |
human |
| Long Pei, Xiaosen Song, Xiangdong Liang, Ming Li, Aili Zhang, Xiaoliang Ta. Circular RNA Dipeptidyl Peptidase 4 (circDPP4) Stimulates the Expression of Glutamate Dehydrogenase 1 to Contribute to the Malignant Phenotypes of Prostate Cancer by Sponging miR-497-5p. Molecular biotechnology. 2023-04-20. PMID:37079266. |
levels of circdpp4, microrna (mir)-497-5p, glutamate dehydrogenase 1 (glud1), proliferating cell nuclear antigen (pcna), bcl2 associated x, apoptosis regulator (bax), e-cadherin and ki67 were gauged by a quantitative real-time polymerase chain reaction (qrt-pcr), western blotting, or immunohistochemical method. |
2023-04-20 |
2023-08-14 |
Not clear |
| Jhimli Banerjee, Sovan Samanta, Rubai Ahmed, Sandeep Kumar Das. Bioactive Pentacyclic Triterpenes Trigger Multiple Signalling Pathways For Selective Apoptosis Leading to Anticancer Efficacy: Recent Updates and Future Perspectives. Current protein & peptide science. 2023-04-19. PMID:37073661. |
the highlighted mechanisms are antiproliferative activity, induction of apoptosis through regulation of bcl2 and bh3 family proteins, modulation of the inflammatory pathway, interference with cell invagination and inhibition of metastasis. |
2023-04-19 |
2023-08-14 |
Not clear |
| Hui Song Cui, So Young Joo, Seung Yeol Lee, Yoon Soo Cho, Dong Hyun Kim, Cheong Hoon Se. Effect of Hypertrophic Scar Fibroblast-Derived Exosomes on Keratinocytes of Normal Human Skin. International journal of molecular sciences. vol 24. issue 7. 2023-04-13. PMID:37047109. |
the expression of proliferation markers (ki-67 and keratin 14), activation markers (keratins 6, 16, and 17), differentiation markers (keratins 1 and 10), apoptosis factors (bax, bcl2, caspase 14, and ask1), proliferation/differentiation regulators (p21 and p27), and epithelial-mesenchymal transition (emt) markers (e-cadherin, n-cadherin, and vimentin) was investigated. |
2023-04-13 |
2023-08-14 |
human |
| Danxue He, Lei Tao, Binxiang Cai, Xiangjun Chen, Yan Wang, Shiying Li, Chunyan Liao, Yuling Chen, Jingmeng Chen, Zuguo Liu, Yalin W. eIF2α incites photoreceptor cell and retina damage by all-trans-retinal. The Journal of biological chemistry. 2023-04-09. PMID:37031820. |
chop overexpression induced apoptosis of atral-loaded photoreceptor cells through activating jnk signaling rather than inhibiting the expression of anti-apoptotic gene bcl2. |
2023-04-09 |
2023-08-14 |
Not clear |
| Sukhbir Singh, Hema Rani, Neelam Sharma, Tapan Behl, Ishrat Zahoor, Hafiz A Makeen, Mohammed Albratty, Hassan A Alhazm, Lotfi Aley. Targeting multifunctional magnetic nanowires for drug delivery in cancer cell death: an emerging paradigm. Environmental science and pollution research international. 2023-04-03. PMID:37010687. |
the apoptosis reduction in cancer development is mediated by (i) an imbalance between pro- and anti-apoptotic proteins, such as members of the b-cell lymphoma-2 (bcl2) family of proteins, tumour protein 53 and inhibitor of apoptosis proteins, (ii) a reduction in caspase activity, and (iii) impaired death receptor signalling. |
2023-04-03 |
2023-08-14 |
Not clear |