| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qingfeng Lv, Yuan Wang, Wei Tian, Yuqiu Liu, Mengqi Gu, Xiaotong Jiang, Yanjun Cai, Ruiheng Huo, Yuchen Li, Lei Li, Xietong Wan. Exosomal miR-146a-5p derived from human umbilical cord mesenchymal stem cells can alleviate antiphospholipid antibody-induced trophoblast injury and placental dysfunction by regulating the TRAF6/NF-κB axis. Journal of nanobiotechnology. vol 21. issue 1. 2023-11-14. PMID:37957714. |
exosomal mir-146a-5p suppressed the expression of tumor necrosis factor receptor-associated factor 6 (traf6) and inhibited the activation of nf-κb signaling, leading to the down-regulation of il-1β and il-18 to rescue inflammation and modulation of cleaved-casp3, bax, and bcl2 to inhibit apoptosis in htr8/svneo cells and mice placenta. |
2023-11-14 |
2023-11-20 |
mouse |
| Dennis Juarez, Roberta Buono, Shannon M Matulis, Vikas A Gupta, Madeleine R Duong, Jacob Yudiono, Madhuri Paul, Sharmila Mallya, Grace Diep, Peter Hsin, Alexander Lu, Sang Mi Suh, Vy M Dong, Andrew W Roberts, Joel D Leverson, Muhammad Jalaluddin, Zhuangzhuang Liu, Orlando F Bueno, Lawrence H Boise, David A Fruma. Statin-induced mitochondrial priming sensitizes multiple myeloma cells to BCL2 and MCL1 inhibitors. Cancer research communications. 2023-11-13. PMID:37956312. |
the bcl2 inhibitor venetoclax promotes apoptosis in blood cancer cells and is approved for treatment of chronic lymphocytic leukemia and acute myeloid leukemia. |
2023-11-13 |
2023-11-20 |
Not clear |
| Cui Wang, Xiaoyi Wang, Yinyin Xie, Tingting Peng, Yongfeng Wang, Nan Li, Xiangbo Huang, Xiaomei Hu, Nanchang Xi. ATF5 attenuates low-magnesium-induced apoptosis by inhibiting endoplasmic reticulum stress via the regulation of mitochondrial reactive oxygen species. Neuroscience. 2023-11-01. PMID:37913858. |
furthermore, atf5 overexpression rescued low-magnesium-induced neuronal apoptosis, as evidenced by the reduced expression levels of cleaved-caspase-3 and bax, and the restored levels of bcl2. |
2023-11-01 |
2023-11-08 |
Not clear |
| Yiwei Liao, Sha Huang, Yuhu Zhang, Honghai Zhang, Haiting Zha. Decrease of Cellular Communication Network Factor 1 (CCN1) Attenuates PTZ-Kindled Epilepsy in Mice. Cellular and molecular neurobiology. 2023-10-21. PMID:37864627. |
silencing of ccn1 also reduces neuronal damage and apoptosis, decreases mrna and protein expression of proapoptotic proteins bax and caspase-3, increases mrna expression of antiapoptotic protein bcl2. |
2023-10-21 |
2023-11-08 |
mouse |
| Yuanlong Li, Hua Fan, Xiong Han, Jun Sun, Ming Ni, Xiaodan Hou, Fengqin Fang, Wei Zhang, Peizhi M. Long Non-Coding RNA MALAT1 Protects Against Spinal Cord Injury via Suppressing microRNA-125b-5p Mediated Microglial M1 Polarization, Neuroinflammation, and Neural Apoptosis. Molecular neurobiology. 2023-10-19. PMID:37858031. |
lncrna malat1 overexpression suppressed the microglial m1 polarization (decreased inos but increased arg1), neuroinflammation (declined ptgs2, tnf-α, il-1β, and il-6), and microglia-induced neural apoptosis (lower tunel positive cells and c-caspase3 but higher bcl2) under lps treatment; its knock-down displayed the opposite trend. |
2023-10-19 |
2023-11-08 |
rat |
| Peng Liu, Liwei Zhao, Laurence Zitvogel, Oliver Kepp, Guido Kroeme. The BCL2 inhibitor venetoclax mediates anticancer effects through dendritic cell activation. Cell death and differentiation. 2023-10-16. PMID:37845384. |
pharmacological bcl2 inhibitors have been developed with the scope of driving bcl2-dependent cancer cells into apoptosis, and one bcl2 antagonist, venetoclax, has been clinically approved for the treatment of specific leukemias and lymphomas. |
2023-10-16 |
2023-11-08 |
Not clear |
| Anna Skwarska, Marina Konoplev. BCL-xL Targeting to Induce Apoptosis and to Eliminate Chemotherapy-Induced Senescent Tumor Cells: From Navitoclax to Platelet-Sparing BCL-xL PROTACs. Cancer research. 2023-10-12. PMID:37824434. |
one of the primary mechanisms by which cancer cells evade death and maintain survival in the face of stress signals is by overexpression of prosurvival b-cell lymphoma 2 (bcl2) family members such as bcl2, bcl-xl, and mcl1, which suppress the intrinsic (mitochondrial) pathway of apoptosis through complex protein and membrane interactions. |
2023-10-12 |
2023-10-15 |
Not clear |
| Samuel Wyatt, Karen Glover, Srinivasulu Dasanna, Monica Lewison, Maribel González-García, Christopher L Colbert, Sangita C Sinh. Epstein-Barr Virus Encoded BCL2, BHRF1, Downregulates Autophagy by Noncanonical Binding of BECN1. Biochemistry. 2023-09-30. PMID:37776275. |
γ-herpesviruses (γhvs) encode bcl2 homologues (vbcl2) that bind the bcl-2 homology 3 domains (bh3ds) of diverse proteins, inhibiting apoptosis and promoting host cell and virus survival. |
2023-09-30 |
2023-10-07 |
Not clear |
| Katja Seipel, Scarlett Kohler, Ulrike Bacher, Thomas Pabs. HSP90 Inhibitor PU-H71 in Combination with BH3-Mimetics in the Treatment of Acute Myeloid Leukemia. Current issues in molecular biology. vol 45. issue 9. 2023-09-27. PMID:37754227. |
the hsp90 inhibitor pu-h71, mcl1 inhibitor s63845, and bcl2 inhibitor venetoclax were assessed as single agents and in combination for their ability to induce apoptosis and cell death in leukemic cells. |
2023-09-27 |
2023-10-07 |
Not clear |
| Yu Xia, Gaoran Ge, Haixiang Xiao, Mingzhou Wu, Tianhao Wang, Chengyong Gu, Huilin Yang, Dechun Gen. REPIN1 regulates iron metabolism and osteoblast apoptosis in osteoporosis. Cell death & disease. vol 14. issue 9. 2023-09-25. PMID:37749079. |
furthermore, the levels of bcl2 and bax, which play a key role in the mitochondrial apoptosis pathway, were affected. |
2023-09-25 |
2023-10-07 |
mouse |
| Yayun Chen, Qian Jiang, Furong Qing, Junxia Xue, Qiuxiang Xiao, Wenji He, Lina Sui, Zhiping Li. MDA5 Enhances Invasive Candida albicans Infection by Regulating Macrophage Apoptosis and Phagocytosis/Killing Functions. Inflammation. 2023-09-23. PMID:37740789. |
instead, mda5 exerted its influence on macrophages and kidneys by modulating the expression of noxa, bcl2, and bax, thereby promoting apoptosis. |
2023-09-23 |
2023-10-07 |
mouse |
| B Haridevamuthu, Raghul Murugan, Boopathi Seenivasan, Ramu Meenatchi, Raman Pachaiappan, Bader O Almutairi, Selvaraj Arokiyaraj, Kathiravan M K, Jesu Arockiara. Synthetic azo-dye, Tartrazine induces neurodevelopmental toxicity via mitochondria-mediated apoptosis in zebrafish embryos. Journal of hazardous materials. vol 461. 2023-09-23. PMID:37741213. |
gene expression analyses revealed broad disruptions in genes associated with antioxidant defense (sod1, cat, and gstp1), mitochondrial dysfunction (mfn2, opa1, and fis1),evoked inflammatory response (nfkb, tnfa, and il1b), apoptosis activation (bcl2, bax, and p53), and neural development (bdnf, mbp, and syn2a). |
2023-09-23 |
2023-10-07 |
human |
| Hejin Lai, Ning Feng, Qiwei Zha. Discovery of the major 15-30 nt mammalian small RNAs, their biogenesis and function. Nature communications. vol 14. issue 1. 2023-09-18. PMID:37723159. |
particularly, snr-2-cp regulates bcl2 by targeting to its 3'utr dependent on ago2, and subsequently regulates apoptosis. |
2023-09-18 |
2023-10-07 |
Not clear |
| Gustavo Axel Elizalde-Velázquez, Selene Elizabeth Herrera-Vázquez, Leobardo Manuel Gómez-Oliván, Sandra García-Medin. Health impact assessment after Danio rerio long-term exposure to environmentally relevant concentrations of metformin and guanylurea. Chemosphere. 2023-09-09. PMID:37689151. |
herein, findings indicate that both compounds induced oxidative damage and increased the expression of genes associated with apoptosis (bax, bcl2, p53, and casp3). |
2023-09-09 |
2023-10-07 |
zebrafish |
| Mohammad Zaer, Alaa Moeinzadeh, Hossein Abolhassani, Neda Rostami, Mohammad Tavakkoli Yaraki, Seyed Arsalan Seyedi, Seyed Ali Nabipoorashrafi, Zahra Bashiri, Kasra Moeinabadi-Bidgoli, Fatemeh Moradbeygi, Ahmad Reza Farmani, Nikoo Hossein-Khannaze. Doxorubicin-loaded Niosomes functionalized with gelatine and alginate as pH-responsive drug delivery system: A 3D printing approach. International journal of biological macromolecules. 2023-09-09. PMID:37689301. |
gene expression could provide an explanation for the antitumor effect of engineered nanocarriers, which significantly reduced metastasis-promoting genes (bcl2, mmp-2, and mmp-9), and significantly enhanced the expression and activity of genes that promote apoptosis (casp-3, casp-8, and casp-9). |
2023-09-09 |
2023-10-07 |
Not clear |
| Jianyong Dong, Jun Cui, Xuanxuan Shi, Tao Wang, Shaohua Li. Itraconazole inhibits proliferation, induces apoptosis, and reduces angiogenesis of hemangioma endothelial cells by downregulating the hedgehog signaling pathway. Heliyon. vol 9. issue 9. 2023-09-07. PMID:37674841. |
moreover, itraconazole induced apoptosis of hemecs by activating the expression of bax and inhibiting the expression of bcl2. |
2023-09-07 |
2023-10-07 |
human |
| Ana F B Silva, Ana N P Morais, Laritza F Lima, Anna C A Ferreira, Renato F Silva, Naiza A R Sá, Satish Kumar, Ariclécio C Oliveira, Benner G Alves, Ana P R Rodrigues, Eduardo L Gastal, Vilceu Bordignon, José R Figueired. Trimethylation profile of histones H3 lysine 4 and 9 in late preantral and early antral caprine follicles grown in vivo versus in vitro in the presence of anethole. Molecular reproduction and development. 2023-09-06. PMID:37671983. |
uncultured in vivo-grown follicles (pa, n = 64; ea, n = 73) were used as controls to assess the methylation profile and genes' expression related to apoptosis cascade (bax, proapoptotic; bcl2, antiapoptotic), steroidogenesis (cyp17, cyp19a1), and demethylation (kdm1ax1, kdm1ax2, kdm3a). |
2023-09-06 |
2023-10-07 |
Not clear |
| Dhaval Dixit, Victoria M Hallisey, Ethan Y S Zhu, Martyna Okuniewska, Ken Cadwell, Jerry E Chipuk, Jordan E Axelrad, Susan R Schwa. Sphingosine 1-phosphate receptor 1 inhibition induces a pro-apoptotic signaling cascade in T cells. bioRxiv : the preprint server for biology. 2023-09-04. PMID:37662380. |
contrary to expectations, we found that s1pr1 limits apoptosis by maintaining the appropriate balance of bcl2 family members via restraint of jnk activity. |
2023-09-04 |
2023-09-07 |
mouse |
| Fereshteh Omidi, Shahrzad Shahbazi, Somayeh Reiisi, Sara Azhdari, Mohammad Reza Karimzade. Glycyrrhizic acid enhances the anticancer activity of cisplatin in the human ovarian cancer cell line. Toxicology in vitro : an international journal published in association with BIBRA. 2023-09-02. PMID:37659683. |
qpcr was used to study the effects of individual and combined treatments with gl and cisplatin on the expression levels of migration genes (mmp2 and mmp9), and some apoptosis pathway genes (caspase-3, -8, -9, and bcl2). |
2023-09-02 |
2023-09-07 |
human |
| Jiwei Wang, Anbin Chen, Zhiwei Xue, Junzhi Liu, Ying He, Guowei Liu, Zhimin Zhao, Wenjie Li, Qing Zhang, Anjing Chen, Jian Wang, Xingang Li, Xinyu Wang, Bin Huan. BCL2L13 promotes mitophagy through DNM1L-mediated mitochondrial fission in glioblastoma. Cell death & disease. vol 14. issue 9. 2023-09-02. PMID:37660127. |
previous studies have shown that bcl2 like 13 (bcl2l13) is a member of the bcl2 family regulating cell growth and apoptosis in different types of tumors. |
2023-09-02 |
2023-09-07 |
Not clear |