| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shucan Dong, Shengwei Jiang, Biwei Hou, Yaokun Li, Baoli Sun, Yongqing Guo, Ming Deng, Dewu Liu, Guangbin Li. miR-128-3p Regulates Follicular Granulosa Cell Proliferation and Apoptosis by Targeting the Growth Hormone Secretagogue Receptor. International journal of molecular sciences. vol 25. issue 5. 2024-03-13. PMID:38473968. |
investigation of the effects of ghsr on gc proliferation and apoptosis revealed that ghsr overexpression promoted the expression of pcna and bcl2, enhanced gc proliferation, and inhibited cell apoptosis, whereas the opposite effects were observed when ghsr expression was inhibited. |
2024-03-13 |
2024-03-15 |
human |
| Xin Zhang, Yujie Huang, Lei Yang, Shuhuang Chen, Youlian Liu, Ni Tang, Zhiqiong Li, Xiaoli Zhang, Liangyu Li, Defang Che. Dietary exposure to 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) induces oxidative damage promoting cell apoptosis primarily via mitochondrial pathway in the hepatopancreas of carp, Cyprinus carpio. Ecotoxicology and environmental safety. vol 274. 2024-03-10. PMID:38461574. |
the results of apoptosis pathway genes showed that the mitochondrial pathway genes bax, casp3, and casp9 were significantly upregulated and bcl2 was significantly downregulated, while the transcription levels of fadd and perk were significantly enhanced. |
2024-03-10 |
2024-03-14 |
cat |
| Zhi-Jie Lu, Wen-Jun Shi, Dong-Dong Ma, Jin-Ge Zhang, Xiao-Bing Long, Si-Ying Li, Fang-Zhou Gao, Qian-Qian Zhang, Guang-Guo Yin. The azole biocide climbazole induces oxidative stress, inflammation, and apoptosis in fish gut. The Science of the total environment. 2024-03-07. PMID:38453063. |
climbazole increased pro-apoptosis-related genes (fadd, bad1, and caspase3), and decreased anti-apoptosis-associated genes (bcl2, and bcl-xl), suggesting a direct reaction to apoptosis. |
2024-03-07 |
2024-03-10 |
cat |
| Xiaoqi Ai, Rui Lin, Zeeshan Ali, Qingjun Zhu, Li Ding, Haitao Shi, Meiling Hon. Seasonal changes in hepatic lipid metabolism and apoptosis in Chinese soft-shelled turtle (Pelodiscus sinensis). Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2024-03-04. PMID:38437998. |
also, the expression levels of genes (ask1, jnk1, and bax) associated with cell apoptosis increased in mid-h and ea, however, the expression of bcl2 was inhibited in mid-h. |
2024-03-04 |
2024-03-07 |
Not clear |
| Samyah T Alanazi, Samir A Salama, Ahmed Magdy El-Ebiary, Abdulelah K Altowairqi, Atheer T Alharthi, Shahad M Alzahrani, Shomokh H Althagafi, Reema A Alotaibi, Ahmed Abd-Eltawab Tamma. Targeting SIRT1, NLRP3 inflammasome, and Nrf2 signaling with chrysin alleviates the iron-triggered hepatotoxicity in rats. Toxicology. 2024-03-03. PMID:38432408. |
in addition, chrysin significantly ameliorated the iol-induced apoptosis as indicated by reduction in caspase-3 activity and modulation of bax and bcl2 protein abundance. |
2024-03-03 |
2024-03-06 |
rat |
| Kittisak Taoma, Marasri Ruengjitchatchawalya, Monrudee Liangruksa, Teeraphan Laomettachi. Boolean modeling of breast cancer signaling pathways uncovers mechanisms of drug synergy. PloS one. vol 19. issue 2. 2024-02-23. PMID:38394152. |
clustering analysis allowed us to identify distinct patterns in the protein activities that correspond to five different modes of synergy: 1) synergistic activation of fadd and bid (extrinsic apoptosis pathway), 2) synergistic inhibition of bcl2 (intrinsic apoptosis pathway), 3) synergistic inhibition of mtorc1, 4) synergistic inhibition of esr1, and 5) synergistic inhibition of cyclin d. our approach offers a mechanistic understanding of the efficacy of drug combinations and provides direction for selecting potential drug pairs worthy of further laboratory investigation. |
2024-02-23 |
2024-02-26 |
Not clear |
| Wei Tan, Yanling Li, Lu Ma, Xinying Fu, Qingyin Long, Fanchen Yan, Wanyu Li, Xiaodan Liu, Huang Ding, Yang Wang, Wei Zhan. Exosomes of endothelial progenitor cells repair injured vascular endothelial cells through the Bcl2/Bax/Caspase-3 pathway. Scientific reports. vol 14. issue 1. 2024-02-23. PMID:38396011. |
notably, epc-exo can adhere to the injured vascular area, promoting enhanced endothelial function and inhibiting vascular endothelial hyperplasia moreover, they regulate the expression of proteins and genes associated with apoptosis, including b-cell lymphoma-2 (bcl2), bcl2-associated x (bax), and caspase-3. |
2024-02-23 |
2024-02-26 |
rat |
| Yilong Guo, Yang Che, Xuelin Zhang, Zongna Ren, Yinan Chen, Liliang Guo, Lin Mao, Ren Wei, Xiang Gao, Tao Zhang, Li Wang, Wei Gu. Cannabidiol protects against acute aortic dissection by inhibiting macrophage infiltration and PMAIP1-induced vascular smooth muscle cell apoptosis. Journal of molecular and cellular cardiology. 2024-02-22. PMID:38387723. |
pmaip1 potentially mediates havsmcs apoptosis by regulating bax and bcl2 expression. |
2024-02-22 |
2024-02-25 |
mouse |
| Mingming Han, Tian Zhu, Zihan Zhou, Qin Si, Chenxi Zhu, Yiming Li, Qichen Jian. Effects of different concentrations and particle sizes of nanoplastics on gut microbiology, metabolism, and immunity in Chiromantes dehaani. Fish & shellfish immunology. 2024-02-21. PMID:38382689. |
in terms of apoptosis, nps exposure led to reduced mrna expression of bcl2 and increased expression of caspase-3, caspase-8, and caspase-9, indicating an induction of apoptosis. |
2024-02-21 |
2024-02-24 |
Not clear |
| Norman Fultang, Ashley M Schwab, Sophia McAneny-Droz, Alexander Grego, Stephanie Rodgers, Brian Vidal Torres, Diane Heiser, Peggy Scherle, Neha Bhagwa. PBRM1 loss is associated with increased sensitivity to MCL1 and CDK9 inhibition in clear cell renal cancer. Frontiers in oncology. vol 14. 2024-02-19. PMID:38371625. |
mcl1 is a member of the bcl2 family of apoptosis regulators, which play a critical role in promoting cancer survival and drug resistance. |
2024-02-19 |
2024-02-21 |
Not clear |
| Akashi Sharma, Aatifa Zehra, Sam J Mathe. Myosin heavy chain-perinatal regulates skeletal muscle differentiation, oxidative phenotype and regeneration. The FEBS journal. 2024-02-15. PMID:38358038. |
paracrine signals mediate the effect of loss of myhc-perinatal function on myogenic differentiation, possibly mediated by non-apoptotic caspase-3 signaling along with enhanced levels of the pro-survival apoptosis regulator bcl2 and nuclear factor kappa-b (nf-κb). |
2024-02-15 |
2024-02-17 |
Not clear |
| Stefano Pagano, Chiara Valenti, Paolo Negri, Monia Billi, Alessandro Di Michele, Stefano Bruscoli, Marta Febo, Maddalena Coniglio, Lorella Marinucc. Acute and chronic cannabidiol treatment: In vitro toxicological aspects on human oral cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2024-02-11. PMID:38342230. |
viability, morphology, migration, apoptosis and cell cycle, and expression of related genes (p53, bcl2, p21, and bax) and of endocannabinoid system receptors (cb1, cb2 and gpr55) with real-time pcr and dna damage with phospho-γ-h2ax immunofluorescence detection were analyzed. |
2024-02-11 |
2024-02-14 |
human |
| Ribrio Ivan Tavares Pereira Batista, Jenniffer Hauschildt Dias, Joedson Dantas Gonçalves, Gabriel Brun Vergani, Maria Emilia Franco Oliveira, Joanna Maria Gonçalves Souza-Fabjan, Jeferson Ferreira Fonsec. The presence of estradiol benzoate in the cervical relaxation treatment for non-surgical embryo collection does not impair embryonic morphological quality, cryosurvival, and gene expression profile. Theriogenology. vol 218. 2024-02-09. PMID:38335708. |
additionally, the presence of eb did not affect (p > 0.05) the embryo's morphological quality, the development dynamics, or the abundance of transcripts associated with embryonic quality (oct4 and nanog), cellular stress (hsp90 and prdx1), and apoptosis (bcl2 and bax). |
2024-02-09 |
2024-02-12 |
Not clear |
| Barbora Loncová, Zuzana Fabová, Vladimíra Mondočková, Radoslav Omelka, Abdel Halim Harrath, Alexander V Sirotki. Inhibition of vinculin activity has an adverse effect on porcine ovarian cells. Experimental cell research. 2024-02-03. PMID:38309674. |
the expression of vcl, accumulation of vcl protein, cell viability, proliferation (accumulation of pcna and cyclin b1), proportion of proliferative active cells, apoptosis (accumulation of bax, caspase 3, p53, antiapoptotic marker bcl2, and bax/bcl-2 ratio), dna fragmentation, and release of steroid hormones and igf-i were analyzed by rt‒qpcr, trypan blue exclusion test, quantitative immunocytochemistry, xtt assay, tunel assay, and elisa. |
2024-02-03 |
2024-02-06 |
Not clear |
| Xueying Ma, Xu Han, Wenwen Wang, Qin Zhang, Hui Tan. β-Catenin regulates ovarian granulosa cell cycle and proliferation in laying hens by interacting with TCF4. Poultry science. vol 103. issue 3. 2024-02-01. PMID:38301496. |
ctnnb1 did not however affect apoptosis or the expression of related genes baculoviral iap repeat containing 5 (birc5) and bcl2 apoptosis regulator (bcl-2). |
2024-02-01 |
2024-02-04 |
Not clear |
| Esmaeel Babaeenezhad, Omid Dezfoulian, Mostafa Moradi Sarabi, Hassan Ahmadvan. Monoterpene linalool restrains gentamicin-mediated acute kidney injury in rats by subsiding oxidative stress, apoptosis, and the NF-κB/iNOS/TNF-α/IL-1β pathway and regulating TGF-β. Naunyn-Schmiedeberg's archives of pharmacology. 2024-01-31. PMID:38294506. |
interestingly, lin repressed gm-induced apoptosis, as reflected by a marked downregulation of bax and caspase-3 expression, concurrent with the upregulation of bcl2 expression. |
2024-01-31 |
2024-02-02 |
rat |
| Dwaipayan Bhattacharya, Madhu Rani Bharati, Kalyani Sakhare, Piyush Khandelia, Rajkumar Banerjee, Kumar Pranav Naraya. Steroid hormone receptor based gene delivery systems as potential oral cancer therapeutics. Biomedical materials (Bristol, England). 2024-01-30. PMID:38290150. |
transfection of oscc cells with exogenous, anticancer gene p53 lipoplexed with crude saponin-based liposome induced apoptosis of cancer cells via regulation of bax and bcl2 protein levels at levels comparable with pre-established delivery systems based on synthetic shr ligands. |
2024-01-30 |
2024-02-02 |
human |
| Fares E M Ali, Khalid S A Badran, Mohammad A Baraka, Hanan S Althagafy, Emad H M Hassanei. Mechanism and impact of heavy metal-aluminum (Al) toxicity on male reproduction: Therapeutic approaches with some phytochemicals. Life sciences. 2024-01-29. PMID:38286208. |
additionally, substantial evidence concluded the key role of apoptosis in al-induced testicular toxicity mediated by upregulating caspase-3 and downregulating bcl2 protein. |
2024-01-29 |
2024-02-01 |
human |
| Oluwadunni E Emiloju, Jun Yin, Emily Koubek, Joel M Reid, Mitesh J Borad, Yanyan Lou, Mahesh Seetharam, Martin J Edelman, Edward A Sausville, Yixing Jiang, Ahmed O Kaseb, James A Posey, Sarah L Davis, Gregory J Gores, Lewis R Roberts, Naoko Takebe, Gary K Schwartz, Andrea E Wahner Hendrickson, Scott H Kaufmann, Alex A Adjei, Joleen M Hubbard, Brian A Costell. Phase 1 trial of navitoclax and sorafenib in patients with relapsed or refractory solid tumors with hepatocellular carcinoma expansion cohort. Investigational new drugs. 2024-01-25. PMID:38270822. |
navitoclax (abt-263) is an oral bcl2 homology-3 mimetic that binds with high affinity to pro-survival bcl2 proteins, resulting in apoptosis. |
2024-01-25 |
2024-01-27 |
Not clear |
| Sergey Shityakov, Viacheslav Kravtsov, Ekaterina V Skorb, Michael Nosonovsk. Ergodicity Breaking and Self-Destruction of Cancer Cells by Induced Genome Chaos. Entropy (Basel, Switzerland). vol 26. issue 1. 2024-01-22. PMID:38248163. |
clones with frequency above 10% result in cell apoptosis, possibly due to mutations in the bcl2 gene. |
2024-01-22 |
2024-01-24 |
rat |