| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yayun Chen, Qian Jiang, Furong Qing, Junxia Xue, Qiuxiang Xiao, Wenji He, Lina Sui, Zhiping Li. MDA5 Enhances Invasive Candida albicans Infection by Regulating Macrophage Apoptosis and Phagocytosis/Killing Functions. Inflammation. 2023-09-23. PMID:37740789. |
instead, mda5 exerted its influence on macrophages and kidneys by modulating the expression of noxa, bcl2, and bax, thereby promoting apoptosis. |
2023-09-23 |
2023-10-07 |
mouse |
| B Haridevamuthu, Raghul Murugan, Boopathi Seenivasan, Ramu Meenatchi, Raman Pachaiappan, Bader O Almutairi, Selvaraj Arokiyaraj, Kathiravan M K, Jesu Arockiara. Synthetic azo-dye, Tartrazine induces neurodevelopmental toxicity via mitochondria-mediated apoptosis in zebrafish embryos. Journal of hazardous materials. vol 461. 2023-09-23. PMID:37741213. |
gene expression analyses revealed broad disruptions in genes associated with antioxidant defense (sod1, cat, and gstp1), mitochondrial dysfunction (mfn2, opa1, and fis1),evoked inflammatory response (nfkb, tnfa, and il1b), apoptosis activation (bcl2, bax, and p53), and neural development (bdnf, mbp, and syn2a). |
2023-09-23 |
2023-10-07 |
human |
| Hejin Lai, Ning Feng, Qiwei Zha. Discovery of the major 15-30 nt mammalian small RNAs, their biogenesis and function. Nature communications. vol 14. issue 1. 2023-09-18. PMID:37723159. |
particularly, snr-2-cp regulates bcl2 by targeting to its 3'utr dependent on ago2, and subsequently regulates apoptosis. |
2023-09-18 |
2023-10-07 |
Not clear |
| Gustavo Axel Elizalde-Velázquez, Selene Elizabeth Herrera-Vázquez, Leobardo Manuel Gómez-Oliván, Sandra García-Medin. Health impact assessment after Danio rerio long-term exposure to environmentally relevant concentrations of metformin and guanylurea. Chemosphere. 2023-09-09. PMID:37689151. |
herein, findings indicate that both compounds induced oxidative damage and increased the expression of genes associated with apoptosis (bax, bcl2, p53, and casp3). |
2023-09-09 |
2023-10-07 |
zebrafish |
| Mohammad Zaer, Alaa Moeinzadeh, Hossein Abolhassani, Neda Rostami, Mohammad Tavakkoli Yaraki, Seyed Arsalan Seyedi, Seyed Ali Nabipoorashrafi, Zahra Bashiri, Kasra Moeinabadi-Bidgoli, Fatemeh Moradbeygi, Ahmad Reza Farmani, Nikoo Hossein-Khannaze. Doxorubicin-loaded Niosomes functionalized with gelatine and alginate as pH-responsive drug delivery system: A 3D printing approach. International journal of biological macromolecules. 2023-09-09. PMID:37689301. |
gene expression could provide an explanation for the antitumor effect of engineered nanocarriers, which significantly reduced metastasis-promoting genes (bcl2, mmp-2, and mmp-9), and significantly enhanced the expression and activity of genes that promote apoptosis (casp-3, casp-8, and casp-9). |
2023-09-09 |
2023-10-07 |
Not clear |
| Jianyong Dong, Jun Cui, Xuanxuan Shi, Tao Wang, Shaohua Li. Itraconazole inhibits proliferation, induces apoptosis, and reduces angiogenesis of hemangioma endothelial cells by downregulating the hedgehog signaling pathway. Heliyon. vol 9. issue 9. 2023-09-07. PMID:37674841. |
moreover, itraconazole induced apoptosis of hemecs by activating the expression of bax and inhibiting the expression of bcl2. |
2023-09-07 |
2023-10-07 |
human |
| Ana F B Silva, Ana N P Morais, Laritza F Lima, Anna C A Ferreira, Renato F Silva, Naiza A R Sá, Satish Kumar, Ariclécio C Oliveira, Benner G Alves, Ana P R Rodrigues, Eduardo L Gastal, Vilceu Bordignon, José R Figueired. Trimethylation profile of histones H3 lysine 4 and 9 in late preantral and early antral caprine follicles grown in vivo versus in vitro in the presence of anethole. Molecular reproduction and development. 2023-09-06. PMID:37671983. |
uncultured in vivo-grown follicles (pa, n = 64; ea, n = 73) were used as controls to assess the methylation profile and genes' expression related to apoptosis cascade (bax, proapoptotic; bcl2, antiapoptotic), steroidogenesis (cyp17, cyp19a1), and demethylation (kdm1ax1, kdm1ax2, kdm3a). |
2023-09-06 |
2023-10-07 |
Not clear |
| Dhaval Dixit, Victoria M Hallisey, Ethan Y S Zhu, Martyna Okuniewska, Ken Cadwell, Jerry E Chipuk, Jordan E Axelrad, Susan R Schwa. Sphingosine 1-phosphate receptor 1 inhibition induces a pro-apoptotic signaling cascade in T cells. bioRxiv : the preprint server for biology. 2023-09-04. PMID:37662380. |
contrary to expectations, we found that s1pr1 limits apoptosis by maintaining the appropriate balance of bcl2 family members via restraint of jnk activity. |
2023-09-04 |
2023-09-07 |
mouse |
| Fereshteh Omidi, Shahrzad Shahbazi, Somayeh Reiisi, Sara Azhdari, Mohammad Reza Karimzade. Glycyrrhizic acid enhances the anticancer activity of cisplatin in the human ovarian cancer cell line. Toxicology in vitro : an international journal published in association with BIBRA. 2023-09-02. PMID:37659683. |
qpcr was used to study the effects of individual and combined treatments with gl and cisplatin on the expression levels of migration genes (mmp2 and mmp9), and some apoptosis pathway genes (caspase-3, -8, -9, and bcl2). |
2023-09-02 |
2023-09-07 |
human |
| Jiwei Wang, Anbin Chen, Zhiwei Xue, Junzhi Liu, Ying He, Guowei Liu, Zhimin Zhao, Wenjie Li, Qing Zhang, Anjing Chen, Jian Wang, Xingang Li, Xinyu Wang, Bin Huan. BCL2L13 promotes mitophagy through DNM1L-mediated mitochondrial fission in glioblastoma. Cell death & disease. vol 14. issue 9. 2023-09-02. PMID:37660127. |
previous studies have shown that bcl2 like 13 (bcl2l13) is a member of the bcl2 family regulating cell growth and apoptosis in different types of tumors. |
2023-09-02 |
2023-09-07 |
Not clear |
| Hoa Dinh, Zsuzsanna Z A Kovács, Fanni Márványkövi, Merse Kis, Klaudia Kupecz, Gergő Szűcs, Marah Freiwan, Gülsüm Yilmaz Lauber, Eylem Acar, Andrea Siska, Katalin Eszter Ibos, Éva Bodnár, András Kriston, Ferenc Kovács, Péter Horváth, Imre Földesi, Gábor Cserni, Bruno K Podesser, Peter Pokreisz, Attila Kiss, László Dux, Krisztina Csabafi, Márta Sárköz. The kisspeptin-1 receptor antagonist peptide-234 aggravates uremic cardiomyopathy in a rat model. Scientific reports. vol 13. issue 1. 2023-08-28. PMID:37640761. |
however, the higher dose of p234 led to reduced anterior and posterior wall thicknesses, more severe interstitial fibrosis, and overexpression of genes associated with left ventricular remodeling (ctgf, tgfb, col3a1, mmp9), stretch (nppa), and apoptosis (bax, bcl2, casp7) compared to the ckd group. |
2023-08-28 |
2023-09-07 |
rat |
| Mirzahossein Norouzi Kamareh, Mohammad Samadi, Ehsan Arabzadeh, Mahkameh Abdollahi, Sadra Sheidaei, Shahin Riyahi Malayeri, Jeffrey Schlicht, Hossein Shirvani, Fatemeh Rostamkhan. The effect of 24-hour sleep deprivation and anaerobic exercise on the expression of BAX, BCL2, BMAL1 and CCAR2 genes in peripheral blood mononuclear cells after L-arginine supplementation. Gene. 2023-08-25. PMID:37625565. |
since a number of studies have shown the anti-apoptotic effect of l-arginine, so the aim of this study was to evaluate the effect of eight weeks of l-arginine supplementation on the expression of brain and muscle arnt-like protein 1 (bmal1), cell cycle and apoptosis regulator 2 (ccar2), and bax and bcl2 genes during sleep deprivation and acute anaerobic exercise. |
2023-08-25 |
2023-09-07 |
human |
| Yuji Sakuma, Sachie Hirai, Toshiyuki Sumi, Toshiro Niki, Miki Yamaguch. Dual inhibition of KIF11 and BCL2L1 induces apoptosis in lung adenocarcinoma cells. Biochemical and biophysical research communications. vol 678. 2023-08-24. PMID:37619315. |
furthermore, dual silencing of kif11 plus bcl2l1, an anti-apoptotic bcl2 family member, in these two egfr-independent sublines resulted in marked apoptosis levels. |
2023-08-24 |
2023-09-07 |
Not clear |
| MuLan Bao, RenGui Bade, Hua Liu, Battseren Tsambaa, Guo Shao, Almaz Borjigidai, Yong Chen. Astragaloside IV against Alzheimer's disease via microglia-mediated neuroinflammation using network pharmacology and experimental validation. European journal of pharmacology. 2023-08-20. PMID:37598923. |
bcl2 apoptosis regulator (bcl-2), pro-apoptotic bcl-2 protein bax, epidermal growth factor receptor (egfr), and receptor tyrosine phosphatase type c (ptprc) were screened for inflammation and microglia in the above targets by network pharmacology. |
2023-08-20 |
2023-09-07 |
Not clear |
| Fang Wang, Yinghong Yu, Gongjian He, Zhangxia Ren, Sizhe X. Downregulation of miR-4284 can inhibit the apoptosis of Human Arterial Smooth Muscle Cells (HASMCs) in arteriosclerosis obliterans (ASO). Combinatorial chemistry & high throughput screening. 2023-08-18. PMID:37594113. |
a western blot technique was used to identify b cell lymphoma-2 (bcl2), bcl2-associated x protein (bax), as well as x-linked inhibitors of apoptosis protein (xiap). |
2023-08-18 |
2023-09-07 |
human |
| Xinyu Wang, Tingting Zhang, Jianlong Zhai, Zhongli Wang, Yan Wang, Lili He, Sai Ma, Hanying Xing, Yifang Gu. MiR-21 attenuates FAS-mediated cardiomyocyte apoptosis by regulating HIPK3 expression. Bioscience reports. 2023-08-15. PMID:37581369. |
our results showed that: (i) mir-21 overexpression or hipk3 downregulation significantly attenuated h9c2 cells apoptosis after h/r; (ii) suppression of mir-21 expression promoted apoptosis; (iii) mir-21 overexpression inhibited hipk3 expression; (iv) hipk3 was the direct and main target of mir-21; (v) mir-21/hipk3 formed part of a reciprocal, negative feedback loop; and (vi) hipk3 downregulation decreased fas-mediated apoptosis by inhibiting the phosphorylation of fadd, which subsequently inhibited the expression of bax and cleaved caspase-3 and increased the expression of bcl2. |
2023-08-15 |
2023-09-07 |
rat |
| Qoyama Noel Baito, Halmat M Jaafar, Talar Ahmad Merza Mohamma. Piperine suppresses inflammatory fibroblast-like synoviocytes derived from rheumatoid arthritis patients Via NF-κB inhibition. Cellular immunology. vol 391-392. 2023-08-03. PMID:37536000. |
moreover, piperine directly reduced the phosphorylation of nf-kb and the expression of nf-κb target genes related to ra-flss proliferation (c-myc and cycline d1), apoptosis inhibition (bcl2 and bcl-xl) and inflammation (cox2, il-1β, tnf-α,il-6, ccl5 and cxcl10) while increasing the expression of apoptosis related ones (bax) in vitro. |
2023-08-03 |
2023-08-14 |
Not clear |
| Ze-Hua Xu, Hang Zhang, Chang-Jun Zhang, Si-Jian Yu, Jing Yuan, Kangxin Jin, Zi-Bing Ji. REG1A protects retinal photoreceptors from blue light damage. Annals of the New York Academy of Sciences. 2023-08-02. PMID:37531162. |
we demonstrate that regenerating islet-derived 1 alpha (reg1a) prevents photoreceptors from undergoing this ld-induced apoptosis by increasing expression of the anti-apoptotic gene bcl2 and downregulating expression of the pro-apoptotic gene bax, resulting in reduced mitochondrial damage and improved aerobic capacity in photoreceptor cells. |
2023-08-02 |
2023-08-14 |
human |
| Ramy Ashry, Al-Hassan M Mustafa, Kristin Hausmann, Michael Linnebacher, Susanne Strand, Wolfgang Sippl, Matthias Wirth, Oliver H Kräme. NOXA Accentuates Apoptosis Induction by a Novel Histone Deacetylase Inhibitor. Cancers. vol 15. issue 14. 2023-07-29. PMID:37509312. |
this is associated with altered expression of bcl2 family members controlling intrinsic apoptosis. |
2023-07-29 |
2023-08-14 |
human |
| Vasudevan Mani, Bander Shehail Alshammer. Quetiapine Moderates Doxorubicin-Induced Cognitive Deficits: Influence of Oxidative Stress, Neuroinflammation, and Cellular Apoptosis. International journal of molecular sciences. vol 24. issue 14. 2023-07-29. PMID:37511284. |
the elisa tests were executed with oxidative [malondialdehyde (mda), catalase, and reduced glutathione (gsh)], inflammatory [cyclooxygenase-2 (cox-2), nuclear factor kappa b (nf-κb), and tumor necrosis factor-alpha (tnf-α)], and apoptosis [b-cell lymphoma 2 (bcl2), bcl2 associated x protein (bax), and caspase-3] markers were assessed in the brain homogenate to explore the related mechanisms. |
2023-07-29 |
2023-08-14 |
rat |