| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xue Zheng, Lu Chen, Tong Chen, Maosheng Cao, Boqi Zhang, Chenfeng Yuan, Zijiao Zhao, Chunjin Li, Xu Zho. The Mechanisms of BDNF Promoting the Proliferation of Porcine Follicular Granulosa Cells: Role of miR-127 and Involvement of the MAPK-ERK1/2 Pathway. Animals : an open access journal from MDPI. vol 13. issue 6. 2023-03-29. PMID:36978655. |
however, bdnf knockdown in gcs decreased cell viability and s-phase cells proportion-and bdnf simultaneously regulated the expression of genes linked with cell proliferation (ccnd1, p21 and bcl2) and apoptosis (bax). |
2023-03-29 |
2023-08-14 |
Not clear |
| Fumihiko Nakao, Kiyoko Setoguchi, Yuichiro Semba, Takuji Yamauchi, Jumpei Nogami, Kensuke Sasaki, Hiroshi Imanaga, Tatsuya Terasaki, Manaka Miyazaki, Shigeki Hirabayashi, Kohta Miyawaki, Yoshikane Kikushige, Takeshi Masuda, Koichi Akashi, Takahiro Maed. Targeting a mitochondrial E3 ubiquitin ligase complex to overcome AML cell-intrinsic Venetoclax resistance. Leukemia. 2023-03-27. PMID:36973350. |
mechanistically, bax released from bcl2 upon ven treatment was entrapped by mcl1 and bcl-xl and failed to induce apoptosis in march5 intact aml cells. |
2023-03-27 |
2023-08-14 |
mouse |
| Yudong Jia, Fenglin Wang, Yuntao Gao, Hongyu Qin, Changtao Gua. Hypoxia stress induces hepatic antioxidant activity and apoptosis, but stimulates immune response and immune-related gene expression in black rockfish Sebastes schlegelii. Aquatic toxicology (Amsterdam, Netherlands). vol 258. 2023-03-25. PMID:36965427. |
in this study, hepatic anti-oxidant enzymes (superoxide dismutase [sod], catalase [cat], glutathione peroxidase [gsh-px]), aminotransferase (ast) and alanine aminotransferase (alt) activities, lipid peroxidation (lpo), malondialdehyde (mda) and glutathione (gsh) content, immunological parameters and the expression of apoptosis (bax, bcl2, p53, caspase3, xiap) and immune-related genes (c3, il-1β, ccl25, saa, hap, isg15) of black rockfish were determined during hypoxia and reoxygenation to illustrate the underlying defense response mechanisms. |
2023-03-25 |
2023-08-14 |
human |
| Haiyan Zhou, Lihong Zhou, Caixia Zhang, Li Zhou, Yuhua Ha. [miR-155-5p alleviates lipopolysaccharide-induced inflammatory damage of human SH-SY5Y neuroblastoma cells by down-regulating SOCS1]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 39. issue 3. 2023-03-22. PMID:36946346. |
results compared with control group, activity of sh-sy5y cells, expression of bcl2 protein, level of il-10 mrna and expression of socs1 protein decreased in lps group while apoptosis rate, expressions of c-caspase-3 and bax proteins, and levels of tnf-α, il-1β and il-6 mrna were increased, along with the increased mir-155-5p level and ratios of p-nf-κb p65/nf-κb p65 and p-p38 mapk/p38 mapk. |
2023-03-22 |
2023-08-14 |
human |
| Haiyan Zhou, Lihong Zhou, Caixia Zhang, Li Zhou, Yuhua Ha. [miR-155-5p alleviates lipopolysaccharide-induced inflammatory damage of human SH-SY5Y neuroblastoma cells by down-regulating SOCS1]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 39. issue 3. 2023-03-22. PMID:36946346. |
the activity of sh-sy5y cells, expression of bcl2 protein, level of il-10 mrna and expression of socs1 protein increased in mir-155-5p inhibitor group, compared with lps group, whereas decreased mir-155-5p level, apoptosis rate, expressions of c-caspase-3 and bax proteins, levels of tnf-α, il-1β and il-6 mrna, and expressions of p-nf-κb p65/nf-κb p65 and p-p38 mapk/p38 mapk proteins were observed. |
2023-03-22 |
2023-08-14 |
human |
| Haiyan Zhou, Lihong Zhou, Caixia Zhang, Li Zhou, Yuhua Ha. [miR-155-5p alleviates lipopolysaccharide-induced inflammatory damage of human SH-SY5Y neuroblastoma cells by down-regulating SOCS1]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 39. issue 3. 2023-03-22. PMID:36946346. |
compared with lps group, activity of sh-sy5y cells, expression of bcl2 protein, level of il-10 mrna and expression of socs1 protein were decreased in mir-155-5p mimic group, while mir-155-5p level, apoptosis rate, expressions of c-caspase-3 and bax proteins, levels of tnf-α, il-1β and il-6 mrna, and ratios of p-nf-κb p65/nf-κb p65 and p-p38 mapk/p38 mapk proteins were increased. |
2023-03-22 |
2023-08-14 |
human |
| Cheng-Jun Hu, Aya Laux, Aneta Gandjeva, Liyi Wang, Min Li, Dale Brown, Suzette Riddle, Vitaly O Kheyfets, Rubin M Tuder, Hui Zhang, Kurt R Stenmar. The Effect of HIF Inhibition on the Phenotype of Fibroblasts in Human and Bovine Pulmonary Hypertension. American journal of respiratory cell and molecular biology. 2023-03-21. PMID:36944195. |
we first established that pulmonary arteries (pas) from human and bovine ph lungs exhibit markedly increased expression of direct hif target genes (ca9, glut1, and ndrg1), as well as of cytokines/chemokines (ccl2, csf2, cxcl12, and il6), growth factors (fgf1, fgf2, pdgfb, and tgfa), and apoptosis resistance genes (bcl2, bcl2l1, and birc5). |
2023-03-21 |
2023-08-14 |
human |
| Zongyu Chen, Shuang He, Siyu Lian, Yi Shen, Wenqing Jiang, Lihua Zhou, Leilei Zhou, Xianming Zhan. The Wnt/β-catenin pathway regulates inflammation and apoptosis in ventilator-induced lung injury. Bioscience reports. vol 43. issue 3. 2023-03-09. PMID:36825682. |
apoptosis of lung tissues was evaluated using tunel, flow cytometry, bax, and bcl2 protein. |
2023-03-09 |
2023-08-16 |
rat |
| Simona Terzo, Pasquale Calvi, Domenico Nuzzo, Pasquale Picone, Mario Allegra, Flavia Mulè, Antonella Amat. Long-Term Ingestion of Sicilian Black Bee Chestnut Honey and/or D-Limonene Counteracts Brain Damage Induced by High Fat-Diet in Obese Mice. International journal of molecular sciences. vol 24. issue 4. 2023-02-25. PMID:36834882. |
the hfd animals showed higher neuronal apoptosis, upregulation of pro-apoptotic genes fas-l, bim p27 and downregulation of anti-apoptotic factors bdnf and bcl2; increased gene expression of the pro-inflammatory il-1β, il-6 and tnf-α and elevated oxidative stress markers cox-2, inos, ros and nitrite. |
2023-02-25 |
2023-08-14 |
mouse |
| Masoumeh Dolati, Farzaneh Tafvizi, Masoud Salehipour, Tahereh Komeili Movahed, Parvaneh Jafar. Biogenic copper oxide nanoparticles from Bacillus coagulans induced reactive oxygen species generation and apoptotic and anti-metastatic activities in breast cancer cells. Scientific reports. vol 13. issue 1. 2023-02-24. PMID:36828883. |
the up-regulation of bcl2-associated x (bax), cyclin dependent kinase inhibitor 1a (p21), caspase 3 (casp3), and caspase 9 (casp9), the down-regulation of bcl2 apoptosis regulator (bcl2), annexin v-fitc/propidium iodide, and reactive oxygen species (ros) generation results suggested that bc-cuonps had a significant apoptotic impact when compared to the control. |
2023-02-24 |
2023-08-14 |
human |
| Laxmidhar Da. Epigenetic alterations impede epithelial-mesenchymal transition by modulating centrosome amplification and Myc/RAS axis in triple negative breast cancer cells. Scientific reports. vol 13. issue 1. 2023-02-11. PMID:36774386. |
in addition, induction of apoptosis was observed by downregulation of bcl2, upregulation of bax and activation of parp cleavage. |
2023-02-11 |
2023-08-14 |
human |
| Fan Yang, Peiwen Xu, Surui Yao, Min Li, Zehua Bian, Zhaohui Huan. Up-regulation of STRA6 predicts poor prognosis and contributes to oxaliplatin resistance in colorectal cancer. Pathology, research and practice. vol 243. 2023-02-09. PMID:36758416. |
additionally, we discovered that stra6 suppresses apoptosis partly by controlling bcl2 expression, which in turn causes crc to become resistant to lohp treatment. |
2023-02-09 |
2023-08-14 |
Not clear |
| Tahmineh Mokhtari, Lu-Peng Yue, Li H. Exogenous melatonin alleviates neuropathic pain-induced affective disorders by suppressing NF-κB/ NLRP3 pathway and apoptosis. Scientific reports. vol 13. issue 1. 2023-02-07. PMID:36747075. |
np upregulated bax, downregulated bcl2, and increased cell apoptosis in the hc and pfc. |
2023-02-07 |
2023-08-14 |
rat |
| Tahmineh Mokhtari, Lu-Peng Yue, Li H. Exogenous melatonin alleviates neuropathic pain-induced affective disorders by suppressing NF-κB/ NLRP3 pathway and apoptosis. Scientific reports. vol 13. issue 1. 2023-02-07. PMID:36747075. |
mlt could promote cell survival from apoptosis by modulating bax and bcl2. |
2023-02-07 |
2023-08-14 |
rat |
| Mohamed A Tantawy, Aziza B Shalby, Ibrhim El-Bernawy, Shahad W Kattan, Ahmed A Abd-Rabou, Gamal A Elmegee. Anti-cancer Activity, and Molecular Docking of Novel Hybrid Heterocyclic Steroids Revealed Promising Anti-hepatocellular Carcinoma Agent: Implication of Cyclin Dependent kinase-2 Pathway. Steroids. 2023-02-03. PMID:36736802. |
moreover, compound 7 induced apoptosis via upregulating the expression of caspase-3, -8, -9, p53, bax and inhibiting the expression of bcl2, and cdk2 genes. |
2023-02-03 |
2023-08-14 |
human |
| Liberalis Debraj Boila, Subhadeep Ghosh, Subham K Bandyopadhyay, Liqing Jin, Alex Murison, Andy G X Zeng, Wasim Shaikh, Satyaki Bhowmik, Siva Sai Naga Anurag Muddineni, Mayukh Biswas, Sayantani Sinha, Shankha Subhra Chatterjee, Nathan Mbong, Olga I Gan, Anwesha Bose, Sayan Chakraborty, Andrea Arruda, James A Kennedy, Amanda Mitchell, Eric R Lechman, Debasis Banerjee, Michael Milyavsky, Mark D Minden, John E Dick, Amitava Sengupt. KDM6 demethylases integrate DNA repair gene regulation and loss of KDM6A sensitizes human acute myeloid leukemia to PARP and BCL2 inhibition. Leukemia. 2023-01-31. PMID:36720973. |
corroborating these results, dual targeting of parp and bcl2 was superior to parp or bcl2 inhibitor monotherapy in inducing aml apoptosis, and primary aml cells carrying kdm6a-domain mutations were even more sensitive to the combination. |
2023-01-31 |
2023-08-14 |
human |
| Weifeng Xu, Caiyun Nie, Xiaobing Che. DUSP4 inhibits autophagic cell death and apoptosis in colorectal cancer by regulating BCL2-Beclin1/Bax signaling. Molecular biology reports. 2023-01-27. PMID:36705792. |
dusp4 is a negative regulator of the map kinase (mapk) jnk, and jnk-mediated bcl2 phosphorylation is associated with apoptosis and autophagic cell death. |
2023-01-27 |
2023-08-14 |
Not clear |
| Weifeng Xu, Caiyun Nie, Xiaobing Che. DUSP4 inhibits autophagic cell death and apoptosis in colorectal cancer by regulating BCL2-Beclin1/Bax signaling. Molecular biology reports. 2023-01-27. PMID:36705792. |
our study aimed to explore the significance of bcl2 phosphorylation-dependent autophagy and apoptosis in dusp4-promoted colorectal carcinogenesis. |
2023-01-27 |
2023-08-14 |
Not clear |
| Xueyun Li, Lili Tian, Xinyi Oiao, Lei Ye, Hong Wang, Mengyun Wang, Jianmin Sang, Fuhong Tian, Ren-Shan Ge, Yiyan Wan. Citrinin inhibits the function of Leydig cells in male rats in prepuberty. Ecotoxicology and environmental safety. vol 252. 2023-01-25. PMID:36696728. |
citrinin at 5 mg/kg markedly decreased the ratio of bcl2 to bax, in consistent with the increased apoptosis in leydig cells judged by tunel assay. |
2023-01-25 |
2023-08-14 |
rat |
| Lina Jia, Tianwen Ma, Liangyu Lv, Yue Yu, Mingchao Zhao, Hong Chen, Li Ga. Endoplasmic reticulum stress mediated by ROS participates in cadmium exposure-induced MC3T3-E1 cell apoptosis. Ecotoxicology and environmental safety. vol 251. 2023-01-20. PMID:36669278. |
in our study, cd is believed to induce mitochondrial dysfunction and endoplasmic reticulum stress (ers) in a dose-dependent manner, thereby leading to apoptosis, as evident by elevated drp1, fis1, grp78, chop, atf4, p-eif2α, p-perk, bax, cleaved caspase 3 proteins expression and ros levels, and decreased the levels of mfn2, opa1, bcl2, and intracellular collagen i, b-alp, runx2, and bgp genes. |
2023-01-20 |
2023-08-14 |
Not clear |