| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hoa Dinh, Zsuzsanna Z A Kovács, Fanni Márványkövi, Merse Kis, Klaudia Kupecz, Gergő Szűcs, Marah Freiwan, Gülsüm Yilmaz Lauber, Eylem Acar, Andrea Siska, Katalin Eszter Ibos, Éva Bodnár, András Kriston, Ferenc Kovács, Péter Horváth, Imre Földesi, Gábor Cserni, Bruno K Podesser, Peter Pokreisz, Attila Kiss, László Dux, Krisztina Csabafi, Márta Sárköz. The kisspeptin-1 receptor antagonist peptide-234 aggravates uremic cardiomyopathy in a rat model. Scientific reports. vol 13. issue 1. 2023-08-28. PMID:37640761. |
however, the higher dose of p234 led to reduced anterior and posterior wall thicknesses, more severe interstitial fibrosis, and overexpression of genes associated with left ventricular remodeling (ctgf, tgfb, col3a1, mmp9), stretch (nppa), and apoptosis (bax, bcl2, casp7) compared to the ckd group. |
2023-08-28 |
2023-09-07 |
rat |
| Mirzahossein Norouzi Kamareh, Mohammad Samadi, Ehsan Arabzadeh, Mahkameh Abdollahi, Sadra Sheidaei, Shahin Riyahi Malayeri, Jeffrey Schlicht, Hossein Shirvani, Fatemeh Rostamkhan. The effect of 24-hour sleep deprivation and anaerobic exercise on the expression of BAX, BCL2, BMAL1 and CCAR2 genes in peripheral blood mononuclear cells after L-arginine supplementation. Gene. 2023-08-25. PMID:37625565. |
since a number of studies have shown the anti-apoptotic effect of l-arginine, so the aim of this study was to evaluate the effect of eight weeks of l-arginine supplementation on the expression of brain and muscle arnt-like protein 1 (bmal1), cell cycle and apoptosis regulator 2 (ccar2), and bax and bcl2 genes during sleep deprivation and acute anaerobic exercise. |
2023-08-25 |
2023-09-07 |
human |
| Yuji Sakuma, Sachie Hirai, Toshiyuki Sumi, Toshiro Niki, Miki Yamaguch. Dual inhibition of KIF11 and BCL2L1 induces apoptosis in lung adenocarcinoma cells. Biochemical and biophysical research communications. vol 678. 2023-08-24. PMID:37619315. |
furthermore, dual silencing of kif11 plus bcl2l1, an anti-apoptotic bcl2 family member, in these two egfr-independent sublines resulted in marked apoptosis levels. |
2023-08-24 |
2023-09-07 |
Not clear |
| MuLan Bao, RenGui Bade, Hua Liu, Battseren Tsambaa, Guo Shao, Almaz Borjigidai, Yong Chen. Astragaloside IV against Alzheimer's disease via microglia-mediated neuroinflammation using network pharmacology and experimental validation. European journal of pharmacology. 2023-08-20. PMID:37598923. |
bcl2 apoptosis regulator (bcl-2), pro-apoptotic bcl-2 protein bax, epidermal growth factor receptor (egfr), and receptor tyrosine phosphatase type c (ptprc) were screened for inflammation and microglia in the above targets by network pharmacology. |
2023-08-20 |
2023-09-07 |
Not clear |
| Fang Wang, Yinghong Yu, Gongjian He, Zhangxia Ren, Sizhe X. Downregulation of miR-4284 can inhibit the apoptosis of Human Arterial Smooth Muscle Cells (HASMCs) in arteriosclerosis obliterans (ASO). Combinatorial chemistry & high throughput screening. 2023-08-18. PMID:37594113. |
a western blot technique was used to identify b cell lymphoma-2 (bcl2), bcl2-associated x protein (bax), as well as x-linked inhibitors of apoptosis protein (xiap). |
2023-08-18 |
2023-09-07 |
human |
| Xinyu Wang, Tingting Zhang, Jianlong Zhai, Zhongli Wang, Yan Wang, Lili He, Sai Ma, Hanying Xing, Yifang Gu. MiR-21 attenuates FAS-mediated cardiomyocyte apoptosis by regulating HIPK3 expression. Bioscience reports. 2023-08-15. PMID:37581369. |
our results showed that: (i) mir-21 overexpression or hipk3 downregulation significantly attenuated h9c2 cells apoptosis after h/r; (ii) suppression of mir-21 expression promoted apoptosis; (iii) mir-21 overexpression inhibited hipk3 expression; (iv) hipk3 was the direct and main target of mir-21; (v) mir-21/hipk3 formed part of a reciprocal, negative feedback loop; and (vi) hipk3 downregulation decreased fas-mediated apoptosis by inhibiting the phosphorylation of fadd, which subsequently inhibited the expression of bax and cleaved caspase-3 and increased the expression of bcl2. |
2023-08-15 |
2023-09-07 |
rat |
| Qoyama Noel Baito, Halmat M Jaafar, Talar Ahmad Merza Mohamma. Piperine suppresses inflammatory fibroblast-like synoviocytes derived from rheumatoid arthritis patients Via NF-κB inhibition. Cellular immunology. vol 391-392. 2023-08-03. PMID:37536000. |
moreover, piperine directly reduced the phosphorylation of nf-kb and the expression of nf-κb target genes related to ra-flss proliferation (c-myc and cycline d1), apoptosis inhibition (bcl2 and bcl-xl) and inflammation (cox2, il-1β, tnf-α,il-6, ccl5 and cxcl10) while increasing the expression of apoptosis related ones (bax) in vitro. |
2023-08-03 |
2023-08-14 |
Not clear |
| Ze-Hua Xu, Hang Zhang, Chang-Jun Zhang, Si-Jian Yu, Jing Yuan, Kangxin Jin, Zi-Bing Ji. REG1A protects retinal photoreceptors from blue light damage. Annals of the New York Academy of Sciences. 2023-08-02. PMID:37531162. |
we demonstrate that regenerating islet-derived 1 alpha (reg1a) prevents photoreceptors from undergoing this ld-induced apoptosis by increasing expression of the anti-apoptotic gene bcl2 and downregulating expression of the pro-apoptotic gene bax, resulting in reduced mitochondrial damage and improved aerobic capacity in photoreceptor cells. |
2023-08-02 |
2023-08-14 |
human |
| Ramy Ashry, Al-Hassan M Mustafa, Kristin Hausmann, Michael Linnebacher, Susanne Strand, Wolfgang Sippl, Matthias Wirth, Oliver H Kräme. NOXA Accentuates Apoptosis Induction by a Novel Histone Deacetylase Inhibitor. Cancers. vol 15. issue 14. 2023-07-29. PMID:37509312. |
this is associated with altered expression of bcl2 family members controlling intrinsic apoptosis. |
2023-07-29 |
2023-08-14 |
human |
| Vasudevan Mani, Bander Shehail Alshammer. Quetiapine Moderates Doxorubicin-Induced Cognitive Deficits: Influence of Oxidative Stress, Neuroinflammation, and Cellular Apoptosis. International journal of molecular sciences. vol 24. issue 14. 2023-07-29. PMID:37511284. |
the elisa tests were executed with oxidative [malondialdehyde (mda), catalase, and reduced glutathione (gsh)], inflammatory [cyclooxygenase-2 (cox-2), nuclear factor kappa b (nf-κb), and tumor necrosis factor-alpha (tnf-α)], and apoptosis [b-cell lymphoma 2 (bcl2), bcl2 associated x protein (bax), and caspase-3] markers were assessed in the brain homogenate to explore the related mechanisms. |
2023-07-29 |
2023-08-14 |
rat |
| Sharmeen Ishteyaque, Karan Singh Yadav, Smriti Verma, Kaveri R Washimkar, Madhav Nilakanth Mugal. CYP2E1 triggered GRP78/ATF6/CHOP signalling axis inhibit apoptosis and promotes progression of hepatocellular carcinoma. Archives of biochemistry and biophysics. 2023-07-27. PMID:37499993. |
meanwhile, cyp2e1 stimulated er-stress reduces bcl2 and downregulates the cleaved caspase 3 thus suppresses apoptosis. |
2023-07-27 |
2023-08-14 |
rat |
| Yuan-Yuan Fang, Cui-Liu Gan, Jian-Chao Peng, Yu-Han Xie, Han-Xiao Song, Ya-Qi Mo, Shi-Yan Ou, Michael Aschner, Yue-Ming Jian. Effects of Manganese and Iron, Alone or in Combination, on Apoptosis in BV2 Cells. Biological trace element research. 2023-07-27. PMID:37500820. |
we used immunoblotting to analyze the effect of manganese, iron alone, or their combined exposure on the activation of caspase9, p53, bax, and bcl2 apoptosis signaling pathways. |
2023-07-27 |
2023-08-14 |
Not clear |
| Yuan-Yuan Fang, Cui-Liu Gan, Jian-Chao Peng, Yu-Han Xie, Han-Xiao Song, Ya-Qi Mo, Shi-Yan Ou, Michael Aschner, Yue-Ming Jian. Effects of Manganese and Iron, Alone or in Combination, on Apoptosis in BV2 Cells. Biological trace element research. 2023-07-27. PMID:37500820. |
and we also found that the apoptosis rate increased, mitochondrial membrane potential decreased, apoptosis-related proteins caspase9, p53, bax, and bcl2 expression increased, and caspase3 activity increased. |
2023-07-27 |
2023-08-14 |
Not clear |
| Nora M Aborehab, Mai A Abd-Elmawla, Abeer M ElSayed, Omar Sabry, Shahira M Ezza. Acovenoside A as a novel therapeutic approach to boost taxol and carboplatin apoptotic and antiproliferative activities in NSCLC: Interplay of miR-630/miR-181a and apoptosis genes. Bioorganic chemistry. vol 139. 2023-07-25. PMID:37490810. |
the present study has proven that the underlying mechanism of acovenoside a is partially attributed to the upregulation of mir-630 and mir-181a gene expressions which in turn targets the intrinsic apoptosis genes as p53, bax and bcl2 as well as caspase 3. |
2023-07-25 |
2023-08-14 |
Not clear |
| Chao-Feng Shi, Fei Han, Xiao Jiang, Zhonghao Zhang, Yingqing Li, Jiankang Wang, Shengqi Sun, Jin-Yi Liu, Jia Ca. Benzo[b]fluoranthene induces male reproductive toxicity and apoptosis via Akt-Mdm2-p53 signaling axis in mouse Leydig cells: Integrating computational toxicology and experimental approaches. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023-07-20. PMID:37473983. |
besides, bbf led to apoptosis in leydig cells, and decreased expressions of p-akt and bcl2, while improving the expressions of p53, bax and cleaved caspase-3 in vivo and in vitro. |
2023-07-20 |
2023-08-14 |
mouse |
| Chao-Feng Shi, Fei Han, Xiao Jiang, Zhonghao Zhang, Yingqing Li, Jiankang Wang, Shengqi Sun, Jin-Yi Liu, Jia Ca. Benzo[b]fluoranthene induces male reproductive toxicity and apoptosis via Akt-Mdm2-p53 signaling axis in mouse Leydig cells: Integrating computational toxicology and experimental approaches. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023-07-20. PMID:37473983. |
similarly, p53 inhibitor pifithrin-α also significantly enhanced the cell vitality, alleviated the apoptosis of tm3 cells induced by bbf, and decreased the expressions of bax and cleaved caspase-3, with the up-regulation of bcl2. |
2023-07-20 |
2023-08-14 |
mouse |
| Hao Yan, Xiangliang Huang, Jiangxin Xu, Ying Zhang, Jiajia Chen, Zhifei Xu, Hui Li, Zeng Wang, Xiaochun Yang, Bo Yang, Qiaojun He, Peihua Lu. Chloroquine Intervenes Nephrotoxicity of Nilotinib through Deubiquitinase USP13-Mediated Stabilization of Bcl-XL. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2023-07-14. PMID:37452432. |
mechanistically, nilotinib induces intrinsic apoptosis by specifically reducing the level of bcl2 like 1 (bcl-xl) in both vascular endothelial cells and renal tubular epithelial cells, as well as in vivo. |
2023-07-14 |
2023-08-14 |
Not clear |
| Heba M Mahmoud, Deiaa E Elsayed Abouzed, Amira M Abo-Youssef, Ramadan A M Hemeid. Zafirlukast protects against hepatic ischemia-reperfusion injury in rats via modulating Bcl-2/Bax and NF-κB/SMAD-4 pathways. International immunopharmacology. vol 122. 2023-07-07. PMID:37418987. |
inflammatory cytokines, tumor necrosis factor alpha (tnf-α) and interleukin-33 (il-33), in addition to apoptosis biomarkers, bcl2 associated x protein (bax), b-cell lymphoma 2 (bcl2) and galactine-9 (gal9) proteins were also assessed. |
2023-07-07 |
2023-08-14 |
rat |
| K C Pramod Bahadur, Anju Maharjan, Manju Acharya, DaEun Lee, Sarina Kusma, Ravi Gautam, Jung-Taek Kwon, ChangYul Kim, KilSoo Kim, HyoungAh Kim, Yong He. Polytetrafluorethylene microplastic particles mediated oxidative stress, inflammation, and intracellular signaling pathway alteration in human derived cell lines. The Science of the total environment. 2023-07-07. PMID:37419366. |
furthermore, expression of the apoptosis regulator, bcl2, was markedly increased in the a549 and u937 cell lines. |
2023-07-07 |
2023-08-14 |
human |
| Feiyang Ma, Xinyan Ma, Fan Yang, Jianzhao Liao, Na Qiao, Wenlan Yu, Qingyue Han, Ying Li, Jiaqiang Pan, Lianmei Hu, Jianying Guo, Zhaoxin Tan. Exposure to copper induces endoplasmic reticulum (ER) stress-mediated apoptosis in chicken (Gallus gallus) myocardium. Veterinary research communications. 2023-07-05. PMID:37405676. |
meanwhile, grp78, grp94, eif2α, atf6, xbp1, chop, bax, bak1, bcl2, caspase-12 and caspase-3 genes levels, and grp78, grp94 and caspase-3 proteins levels were increased, which indicated that er stress and apoptosis in cardiomyocytes. |
2023-07-05 |
2023-08-14 |
chicken |