| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rajan Kumar Tiwari, Shiv Govind Rawat, Vishal Kumar Gupta, Pradip Kumar Jaiswara, Pratishtha Sonker, Santosh Kumar, Vibhav Gautam, Manoj K Mishra, Ajay Kuma. Epinephrine facilitates the growth of T cell lymphoma by altering cell proliferation, apoptosis, and glucose metabolism. Chemico-biological interactions. 2022-11-24. PMID:36423730. |
in addition, epinephrine inhibited apoptosis in t lymphoma cells possibly by increasing the level of bcl2 (an anti-apoptotic protein) and decreasing parp level (a pro-apoptotic protein). |
2022-11-24 |
2023-08-14 |
Not clear |
| Lei Zhao, Tony Hsiao, Connor Stonesifer, Jay Daniels, Tiffany J Garcia-Saleem, Jaehyuk Choi, Larisa Geskin, Alain H Rook, Gary S Woo. The Robust Tumoricidal Effects of Combined BET/HDAC Inhibition in Cutaneous T-Cell Lymphoma Can Be Reproduced by ΔNp73 Depletion. The Journal of investigative dermatology. vol 142. issue 12. 2022-11-23. PMID:35787399. |
at 96 hours when apoptosis was extensive, a majority of ctcl lines showed ≥2-fold suppression of t-cell survival factors (e.g., akt1, bcl2 antiapoptotic factors, birc5, cd40, cd70, gadd45a, prkca, tnfrsf1b, Δnp73) and ≥2-fold upregulation of proapoptotic factors and tumor suppressors (e.g., atm, bak, bim, multiple caspases, fhit, hic1, mgmt, nod1) (p < 0.05). |
2022-11-23 |
2023-12-10 |
Not clear |
| Daniel Dunham, Prasanth Viswanathan, Jackson Gill, Mark Manzan. Expression Ratios of the Antiapoptotic BCL2 Family Members Dictate the Selective Addiction of Kaposi's Sarcoma-Associated Herpesvirus-Transformed Primary Effusion Lymphoma Cell Lines to MCL1. Journal of virology. 2022-11-23. PMID:36416587. |
mcl1 is a member of the bcl2 family, which functions to prevent intrinsic apoptosis and has been implicated in several cancers. |
2022-11-23 |
2023-08-14 |
Not clear |
| Daniel Dunham, Prasanth Viswanathan, Jackson Gill, Mark Manzan. Expression Ratios of the Antiapoptotic BCL2 Family Members Dictate the Selective Addiction of Kaposi's Sarcoma-Associated Herpesvirus-Transformed Primary Effusion Lymphoma Cell Lines to MCL1. Journal of virology. 2022-11-23. PMID:36416587. |
ectopic expression of several bcl2 family proteins, as well as the kshv bcl2 homolog, significantly decreased basal caspase 3/7 activity and buffered against staurosporine-induced apoptosis. |
2022-11-23 |
2023-08-14 |
Not clear |
| Fatemeh Jamshidi-Adegani, Shokoofeh Ghaemi, Sulaiman Al-Hashmi, Saeid Vakilian, Juhaina Al-Kindi, Najeeb Ur Rehman, Khurshid Alam, Khamis Al-Riyami, Rene Csuk, Ehsan Arefian, Ahmed Al-Harras. Comparative study of the cytotoxicity, apoptotic, and epigenetic effects of Boswellic acid derivatives on breast cancer. Scientific reports. vol 12. issue 1. 2022-11-21. PMID:36411309. |
the expression of p53, bax, and bcl2 genes in cancerous cell lines has affirmed that both akba and aba could induce the maximal apoptosis. |
2022-11-21 |
2023-08-14 |
Not clear |
| Jing Wang, Qing-Guo Jin, Rong-Ping Liu, Xin-Qin Wang, Ying-Hua Li, Nam-Hyung Kim, Yong-Nan X. Dihydromyricetin supplementation during in vitro culture improves porcine oocyte developmental competence by regulating oxidative stress. The Journal of reproduction and development. 2022-11-20. PMID:36403957. |
further, dhm supplementation also improved glutathione levels and mitochondrial membrane potential; reduced natural reactive oxygen species levels in blastomeres and apoptosis rate; upregulated nanog, oct4, sod1, sod2, sirt1, and bcl2 expression; and downregulated beclin1, atg12, and bax expression. |
2022-11-20 |
2023-08-14 |
Not clear |
| Ahmed Ismail, Hamada Ahmed Mokhlis, Marwa Sharaky, Mohamed H Sobhy, Sherif S Hassanein, Ahmed S Doghish, Salama A Salama, Amr D Mariee, Yasmin M Atti. Hydroxycitric acid reverses tamoxifen resistance through inhibition of ATP citrate lyase. Pathology, research and practice. vol 240. 2022-11-19. PMID:36401980. |
moreover, apoptosis marker caspase-3 and bax were increased, while the anti-apoptotic bcl2 was decreased. |
2022-11-19 |
2023-08-14 |
Not clear |
| Jinfeng Liu, Chang Zhang, Shuang Liu, Xiaokang Wang, Xiongzhi Wu, Jian Ha. Tanshinone IIA promotes apoptosis by downregulating BCL2 and upregulating TP53 in triple-negative breast cancer. Naunyn-Schmiedeberg's archives of pharmacology. 2022-11-14. PMID:36374307. |
tanshinone iia promotes apoptosis by downregulating bcl2 and upregulating tp53 in triple-negative breast cancer. |
2022-11-14 |
2023-08-14 |
Not clear |
| b' Sema Bilgin, Secil Erden Tayhan, Asl\\xc4\\xb1 Y\\xc4\\xb1ld\\xc4\\xb1r\\xc4\\xb1m, Esra Ko\\xc3\\xa. Investigation of the effects of isoeugenol-based phenolic compounds on migration and proliferation of HT29 colon cancer cells at cellular and molecular level. Bioorganic chemistry. vol 130. 2022-11-14. PMID:36375352.' |
in addition, mrna expression levels of apoptosis and metastasis-related genes (p53, bcl2, bax, caspase 3, caspase7, caspase8, caspase9, hif1-α, vegf, mmp-2, mmp-9) were examined by quantitative real-time pcr. |
2022-11-14 |
2023-08-14 |
Not clear |
| Joaquim Carreras, Giovanna Roncador, Rifat Hamoud. Artificial Intelligence Predicted Overall Survival and Classified Mature B-Cell Neoplasms Based on Immuno-Oncology and Immune Checkpoint Panels. Cancers. vol 14. issue 21. 2022-11-11. PMID:36358737. |
oncogenes and tumor suppressor genes were highlighted (myc, bcl2, and tp53), along with immune microenvironment markers of tumor-associated macrophages (m2-like tams), t-cells and regulatory t lymphocytes (tregs) (cd68, cd163, marco, csf1r, csf1, pd-l1/cd274, sirpa, cd85a/lilrb3, cd47, il10, tnfrsf14/hvem, tnfaip8, ikaros, stat3, nfkb, mapk, pd-1/pdcd1, btla, and foxp3), apoptosis (bcl2, casp3, casp8, parp, and pathway-related mdm2, e2f1, cdk6, myb, and lmo2), and metabolism (eno3, gga3). |
2022-11-11 |
2023-08-14 |
Not clear |
| Seenipandi Arunachalam, Mohamed Fizur Nagoor Meeran, Sheikh Azimullah, Niraj Kumar Jha, Dhanya Saraswathiamma, Alia Albawardi, Rami Beiram, Shreesh Ojh. α-Bisabolol Attenuates NF-κB/MAPK Signaling Activation and ER-Stress-Mediated Apoptosis by Invoking Nrf2-Mediated Antioxidant Defense Systems against Doxorubicin-Induced Testicular Toxicity in Rats. Nutrients. vol 14. issue 21. 2022-11-11. PMID:36364909. |
dox triggered apoptosis, manifested by an increment in the expression levels of pro-apoptotic markers (bax, bcl2, cleaved caspase-3 and -9, and cytochrome-c) and a decline in the expression levels of anti-apoptotic markers (bcl-xl and bcl2) in the testis. |
2022-11-11 |
2023-08-14 |
rat |
| Yanxia Xiong, Chengyuan Wang, Mengyi Dong, Meifeng Li, Chengyu Hu, Xiaowen X. Chlorphoxim induces neurotoxicity in zebrafish embryo through activation of oxidative stress. Environmental toxicology. 2022-11-04. PMID:36331003. |
as expected, chlorphoxim exposure induces apoptosis by enhancing the expression of apoptotic genes (bax, bcl2, and p53). |
2022-11-04 |
2023-08-14 |
cat |
| Shijie Lyu, Yaying Zhai, Xiaoting Zhu, Qiaoting Shi, Fuying Chen, Geyang Zhang, Zijing Zhang, Eryao Wan. Bta-miR-200b promotes endometrial epithelial cell apoptosis by targeting MYB in cattle. Theriogenology. vol 195. 2022-11-04. PMID:36332375. |
overexpression of bta-mir-200b upregulated the expression of proapoptotic gene bcl2 associated x, apoptosis regulator (bax) and endometrial receptivity marker gene osteopontin (opn) at mrna and protein level in bovine endometrial epithelial cells. |
2022-11-04 |
2023-08-14 |
cattle |
| Xinxu Zhang, Min Li, Hao Wu, Weiyang Fan, Jiashuo Zhang, Weiwei Su, Yonggang Wang, Peibo L. Naringenin attenuates inflammation, apoptosis and ferroptosis in silver nanoparticle-induced lung injury through a mechanism associated with Nrf2/HO-1 axis: In vitro and in vivo studies. Life sciences. 2022-10-28. PMID:36306867. |
moreover, naringenin attenuated agnps-induced apoptosis with modulated low bax, cytc, cleaved caspase9, cleaved caspase3 but high bcl2. |
2022-10-28 |
2023-08-14 |
mouse |
| Andry Ny Aina Rabezanahary, Mathilde Piette, Omayma Missawi, Mutien- Marie Garigliany, Patrick Kestemont, Cornet Valéri. Microplastics alter development, behavior, and innate immunity responses following bacterial infection during zebrafish embryo-larval development. Chemosphere. 2022-10-28. PMID:36306963. |
our results indicated a difference in immune system (nfkb, il1β) and apoptosis (casp3a, bcl2) related gene expression depending on the timing of mp exposure, which highlighted a contrasting sensitivity according to the exposure time in mp studies. |
2022-10-28 |
2023-08-14 |
zebrafish |
| Feng Jiang, Tieming Zhu, Chunfeng Yang, Yang Chen, Zhidong Fu, Lihui Jiang, Yongzhi Li. Pachymic acid inhibits growth and metastatic potential in liver cancer HepG2 and Huh7 cells. Biological & pharmaceutical bulletin. 2022-10-23. PMID:36273899. |
mechanistically, we revealed that pachymic acid triggered cell apoptosis by increasing caspase 3 and caspase 9 cleavage, upregulating bax and cytochrome c expression, while reducing the expression of bcl2. |
2022-10-23 |
2023-08-14 |
Not clear |
| Medha, Priyanka, Parul Bhatt, Sadhna Sharma, Monika Sharm. Role of C-terminal domain of Mycobacterium tuberculosis PE6 (Rv0335c) protein in host mitochondrial stress and macrophage apoptosis. Apoptosis : an international journal on programmed cell death. 2022-10-18. PMID:36258102. |
since, c-terminal of bcl2 proteins are crucial for mitochondria targeting and apoptosis; it became relevant to evaluate the role of rv0335c's c-terminal domain in modulating host mitochondrial functions and apoptosis. |
2022-10-18 |
2023-08-14 |
Not clear |
| Lívia Bassani Lins de Miranda, Keli Lima, Juan Luiz Coelho-Silva, Fabiola Traina, Susumu S Kobayashi, João Agostinho Machado-Net. NT157 exerts antineoplastic activity by targeting JNK and AXL signaling in lung cancer cells. Scientific reports. vol 12. issue 1. 2022-10-12. PMID:36224313. |
besides, nt157 decreased expression of oncogenes bcl2, ccnd1, myb, and myc and increased genes related to cellular stress and apoptosis, jun, bbc3, cdkn1a, cdkn1b, fos, and egr1 (p < 0.05), favoring a tumor-suppressive cell signaling network in the context of lung cancer. |
2022-10-12 |
2023-08-14 |
Not clear |
| Juan He, Shengyuan Liu, Xujun Guo, Fan Zhang, Howard Eugene Takiff, Yashuang Zha. Polymorphisms of the BCL2 gene associated with susceptibility to tuberculosis. Revista do Instituto de Medicina Tropical de Sao Paulo. vol 64. 2022-10-05. PMID:36197420. |
apoptosis plays a role in the interaction of mycobacterium tuberculosis (mtb) with the human host and it may be modified by subtle alterations in the b-cell lymphoma 2 (bcl2) gene, an anti-apoptotic regulatory element. |
2022-10-05 |
2023-08-14 |
human |
| Xing Liu, Jiahui Dong, Yue Xian, Zongfang Re. [lncRNA-HOTAIR inhibits the proliferation of H9c2 rat cardiomyocytes induced by lipopolysaccharide and promotes inflammation through targeting negative regulation of miR-1-3p]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 38. issue 10. 2022-09-27. PMID:36163622. |
compared with the lps combined with si-nc group, the lps combined with si-hotair treated h9c2 cell proliferation activity, presenting increased ki67 and bcl2 expression, as well as decreased level of p21 expression, apoptosis rate, bax expression, il-6 and tnf-α. |
2022-09-27 |
2023-08-14 |
rat |