| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhijing Zhang, Lideng Guo, Fei Yang, Shanpan Peng, Di Wang, Xiawei Lai, Baiqin Su, Haihui Xi. Adiponectin Attenuates Splenectomy-Induced Cognitive Deficits by Neuroinflammation and Oxidative Stress via TLR4/MyD88/NF-κb Signaling Pathway in Aged Rats. ACS chemical neuroscience. 2023-05-04. PMID:37141577. |
further experiments indicated that apn could inhibit the toll-like receptor 4 (tlr4)/myeloid differentiation factor 88 (myd88)/nuclear factor kappa b (nf-κb) p65 pathway to decrease the degree of oxidative damage (malondialdehyde (mda) and superoxide dismutase (sod)), microglia-mediated neuroinflammation (ionized calcium binding adapter molecule 1 (iba1), caspase-1, tumor necrosis factor (tnf)-α, interleukin-1β (il-1β), and interleukin-6 (il-6)), and apoptosis (p53, bcl2, bax, and caspase 3) in hippocampus. |
2023-05-04 |
2023-08-14 |
rat |
| Tianli Shen, Shuanying Yang, Xiaoyan Qu, Zilu Chen, Lizhong Zeng, Xuejun Sun, Yuyao Lin, Meng Luo, Bo Lei, Chenyang Yue, Chunhong Ma, Nan Hu, Wei Wang, Long Zhan. A bionic "Trojan horse"-like gene delivery system hybridized with tumor and macrophage cell membrane for cancer therapy. Journal of controlled release : official journal of the Controlled Release Society. 2023-04-30. PMID:37121518. |
m@nps/mir21 can deliver mir21 antagomir into mc38 cancer cells and tumor tissues, promote tumor apoptosis, and regulate the expression of bcl2 and ki67. |
2023-04-30 |
2023-08-14 |
Not clear |
| Dan Shan, Xin Wen, Xiaoju Guan, Hangping Fang, Yijia Liu, Mengjie Qin, Hu Wang, Jingfeng Xu, Jieqiang Lv, Junzhao Zhao, Haolin Che. Pubertal lead exposure affects ovary development, folliculogenesis and steroidogenesis by activation of IRE1α-JNK signaling pathway in rat. Ecotoxicology and environmental safety. vol 257. 2023-04-22. PMID:37086621. |
such activation may also result in apoptosis since the death-signaling molecules chop and cleaved-casp3 were up-regulated while bcl2 was down-regulated. |
2023-04-22 |
2023-08-14 |
rat |
| Zhanhang Wang, Yonglong He, Shujuan Liu, Xiaolong Xu, Yuxuan Song, Lei Zhang, Xiaopeng A. Toxic effects of zinc oxide nanoparticles as a food additive in goat mammary epithelial cells. Food research international (Ottawa, Ont.). vol 167. 2023-04-22. PMID:37087259. |
moreover, the expression levels of bax, cytc, caspase 3 and caspase 9 were upregulated, while the expression levels of bcl2 were downregulated, which indicated mitochondria-mediated intrinsic apoptosis pathway was activated. |
2023-04-22 |
2023-08-14 |
Not clear |
| Chao Li, Jingwen Wang, Jun Feng, Gaoliang Zhou, Yongjin Jiang, Chunmiao Luo, Ziping Cheng, Jiehua L. Circ-JA760602 promotes the apoptosis of hypoxia-induced cardiomyocytes through transcriptionally suppressing BCL2. The International journal of developmental biology. 2023-04-20. PMID:37078361. |
circ-ja760602 promotes the apoptosis of hypoxia-induced cardiomyocytes through transcriptionally suppressing bcl2. |
2023-04-20 |
2023-08-14 |
human |
| Long Pei, Xiaosen Song, Xiangdong Liang, Ming Li, Aili Zhang, Xiaoliang Ta. Circular RNA Dipeptidyl Peptidase 4 (circDPP4) Stimulates the Expression of Glutamate Dehydrogenase 1 to Contribute to the Malignant Phenotypes of Prostate Cancer by Sponging miR-497-5p. Molecular biotechnology. 2023-04-20. PMID:37079266. |
levels of circdpp4, microrna (mir)-497-5p, glutamate dehydrogenase 1 (glud1), proliferating cell nuclear antigen (pcna), bcl2 associated x, apoptosis regulator (bax), e-cadherin and ki67 were gauged by a quantitative real-time polymerase chain reaction (qrt-pcr), western blotting, or immunohistochemical method. |
2023-04-20 |
2023-08-14 |
Not clear |
| Jhimli Banerjee, Sovan Samanta, Rubai Ahmed, Sandeep Kumar Das. Bioactive Pentacyclic Triterpenes Trigger Multiple Signalling Pathways For Selective Apoptosis Leading to Anticancer Efficacy: Recent Updates and Future Perspectives. Current protein & peptide science. 2023-04-19. PMID:37073661. |
the highlighted mechanisms are antiproliferative activity, induction of apoptosis through regulation of bcl2 and bh3 family proteins, modulation of the inflammatory pathway, interference with cell invagination and inhibition of metastasis. |
2023-04-19 |
2023-08-14 |
Not clear |
| Hui Song Cui, So Young Joo, Seung Yeol Lee, Yoon Soo Cho, Dong Hyun Kim, Cheong Hoon Se. Effect of Hypertrophic Scar Fibroblast-Derived Exosomes on Keratinocytes of Normal Human Skin. International journal of molecular sciences. vol 24. issue 7. 2023-04-13. PMID:37047109. |
the expression of proliferation markers (ki-67 and keratin 14), activation markers (keratins 6, 16, and 17), differentiation markers (keratins 1 and 10), apoptosis factors (bax, bcl2, caspase 14, and ask1), proliferation/differentiation regulators (p21 and p27), and epithelial-mesenchymal transition (emt) markers (e-cadherin, n-cadherin, and vimentin) was investigated. |
2023-04-13 |
2023-08-14 |
human |
| Danxue He, Lei Tao, Binxiang Cai, Xiangjun Chen, Yan Wang, Shiying Li, Chunyan Liao, Yuling Chen, Jingmeng Chen, Zuguo Liu, Yalin W. eIF2α incites photoreceptor cell and retina damage by all-trans-retinal. The Journal of biological chemistry. 2023-04-09. PMID:37031820. |
chop overexpression induced apoptosis of atral-loaded photoreceptor cells through activating jnk signaling rather than inhibiting the expression of anti-apoptotic gene bcl2. |
2023-04-09 |
2023-08-14 |
Not clear |
| Sukhbir Singh, Hema Rani, Neelam Sharma, Tapan Behl, Ishrat Zahoor, Hafiz A Makeen, Mohammed Albratty, Hassan A Alhazm, Lotfi Aley. Targeting multifunctional magnetic nanowires for drug delivery in cancer cell death: an emerging paradigm. Environmental science and pollution research international. 2023-04-03. PMID:37010687. |
the apoptosis reduction in cancer development is mediated by (i) an imbalance between pro- and anti-apoptotic proteins, such as members of the b-cell lymphoma-2 (bcl2) family of proteins, tumour protein 53 and inhibitor of apoptosis proteins, (ii) a reduction in caspase activity, and (iii) impaired death receptor signalling. |
2023-04-03 |
2023-08-14 |
Not clear |
| Xue Zheng, Lu Chen, Tong Chen, Maosheng Cao, Boqi Zhang, Chenfeng Yuan, Zijiao Zhao, Chunjin Li, Xu Zho. The Mechanisms of BDNF Promoting the Proliferation of Porcine Follicular Granulosa Cells: Role of miR-127 and Involvement of the MAPK-ERK1/2 Pathway. Animals : an open access journal from MDPI. vol 13. issue 6. 2023-03-29. PMID:36978655. |
however, bdnf knockdown in gcs decreased cell viability and s-phase cells proportion-and bdnf simultaneously regulated the expression of genes linked with cell proliferation (ccnd1, p21 and bcl2) and apoptosis (bax). |
2023-03-29 |
2023-08-14 |
Not clear |
| Fumihiko Nakao, Kiyoko Setoguchi, Yuichiro Semba, Takuji Yamauchi, Jumpei Nogami, Kensuke Sasaki, Hiroshi Imanaga, Tatsuya Terasaki, Manaka Miyazaki, Shigeki Hirabayashi, Kohta Miyawaki, Yoshikane Kikushige, Takeshi Masuda, Koichi Akashi, Takahiro Maed. Targeting a mitochondrial E3 ubiquitin ligase complex to overcome AML cell-intrinsic Venetoclax resistance. Leukemia. 2023-03-27. PMID:36973350. |
mechanistically, bax released from bcl2 upon ven treatment was entrapped by mcl1 and bcl-xl and failed to induce apoptosis in march5 intact aml cells. |
2023-03-27 |
2023-08-14 |
mouse |
| Yudong Jia, Fenglin Wang, Yuntao Gao, Hongyu Qin, Changtao Gua. Hypoxia stress induces hepatic antioxidant activity and apoptosis, but stimulates immune response and immune-related gene expression in black rockfish Sebastes schlegelii. Aquatic toxicology (Amsterdam, Netherlands). vol 258. 2023-03-25. PMID:36965427. |
in this study, hepatic anti-oxidant enzymes (superoxide dismutase [sod], catalase [cat], glutathione peroxidase [gsh-px]), aminotransferase (ast) and alanine aminotransferase (alt) activities, lipid peroxidation (lpo), malondialdehyde (mda) and glutathione (gsh) content, immunological parameters and the expression of apoptosis (bax, bcl2, p53, caspase3, xiap) and immune-related genes (c3, il-1β, ccl25, saa, hap, isg15) of black rockfish were determined during hypoxia and reoxygenation to illustrate the underlying defense response mechanisms. |
2023-03-25 |
2023-08-14 |
human |
| Haiyan Zhou, Lihong Zhou, Caixia Zhang, Li Zhou, Yuhua Ha. [miR-155-5p alleviates lipopolysaccharide-induced inflammatory damage of human SH-SY5Y neuroblastoma cells by down-regulating SOCS1]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 39. issue 3. 2023-03-22. PMID:36946346. |
results compared with control group, activity of sh-sy5y cells, expression of bcl2 protein, level of il-10 mrna and expression of socs1 protein decreased in lps group while apoptosis rate, expressions of c-caspase-3 and bax proteins, and levels of tnf-α, il-1β and il-6 mrna were increased, along with the increased mir-155-5p level and ratios of p-nf-κb p65/nf-κb p65 and p-p38 mapk/p38 mapk. |
2023-03-22 |
2023-08-14 |
human |
| Haiyan Zhou, Lihong Zhou, Caixia Zhang, Li Zhou, Yuhua Ha. [miR-155-5p alleviates lipopolysaccharide-induced inflammatory damage of human SH-SY5Y neuroblastoma cells by down-regulating SOCS1]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 39. issue 3. 2023-03-22. PMID:36946346. |
the activity of sh-sy5y cells, expression of bcl2 protein, level of il-10 mrna and expression of socs1 protein increased in mir-155-5p inhibitor group, compared with lps group, whereas decreased mir-155-5p level, apoptosis rate, expressions of c-caspase-3 and bax proteins, levels of tnf-α, il-1β and il-6 mrna, and expressions of p-nf-κb p65/nf-κb p65 and p-p38 mapk/p38 mapk proteins were observed. |
2023-03-22 |
2023-08-14 |
human |
| Haiyan Zhou, Lihong Zhou, Caixia Zhang, Li Zhou, Yuhua Ha. [miR-155-5p alleviates lipopolysaccharide-induced inflammatory damage of human SH-SY5Y neuroblastoma cells by down-regulating SOCS1]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 39. issue 3. 2023-03-22. PMID:36946346. |
compared with lps group, activity of sh-sy5y cells, expression of bcl2 protein, level of il-10 mrna and expression of socs1 protein were decreased in mir-155-5p mimic group, while mir-155-5p level, apoptosis rate, expressions of c-caspase-3 and bax proteins, levels of tnf-α, il-1β and il-6 mrna, and ratios of p-nf-κb p65/nf-κb p65 and p-p38 mapk/p38 mapk proteins were increased. |
2023-03-22 |
2023-08-14 |
human |
| Cheng-Jun Hu, Aya Laux, Aneta Gandjeva, Liyi Wang, Min Li, Dale Brown, Suzette Riddle, Vitaly O Kheyfets, Rubin M Tuder, Hui Zhang, Kurt R Stenmar. The Effect of HIF Inhibition on the Phenotype of Fibroblasts in Human and Bovine Pulmonary Hypertension. American journal of respiratory cell and molecular biology. 2023-03-21. PMID:36944195. |
we first established that pulmonary arteries (pas) from human and bovine ph lungs exhibit markedly increased expression of direct hif target genes (ca9, glut1, and ndrg1), as well as of cytokines/chemokines (ccl2, csf2, cxcl12, and il6), growth factors (fgf1, fgf2, pdgfb, and tgfa), and apoptosis resistance genes (bcl2, bcl2l1, and birc5). |
2023-03-21 |
2023-08-14 |
human |
| Zongyu Chen, Shuang He, Siyu Lian, Yi Shen, Wenqing Jiang, Lihua Zhou, Leilei Zhou, Xianming Zhan. The Wnt/β-catenin pathway regulates inflammation and apoptosis in ventilator-induced lung injury. Bioscience reports. vol 43. issue 3. 2023-03-09. PMID:36825682. |
apoptosis of lung tissues was evaluated using tunel, flow cytometry, bax, and bcl2 protein. |
2023-03-09 |
2023-08-16 |
rat |
| Simona Terzo, Pasquale Calvi, Domenico Nuzzo, Pasquale Picone, Mario Allegra, Flavia Mulè, Antonella Amat. Long-Term Ingestion of Sicilian Black Bee Chestnut Honey and/or D-Limonene Counteracts Brain Damage Induced by High Fat-Diet in Obese Mice. International journal of molecular sciences. vol 24. issue 4. 2023-02-25. PMID:36834882. |
the hfd animals showed higher neuronal apoptosis, upregulation of pro-apoptotic genes fas-l, bim p27 and downregulation of anti-apoptotic factors bdnf and bcl2; increased gene expression of the pro-inflammatory il-1β, il-6 and tnf-α and elevated oxidative stress markers cox-2, inos, ros and nitrite. |
2023-02-25 |
2023-08-14 |
mouse |
| Masoumeh Dolati, Farzaneh Tafvizi, Masoud Salehipour, Tahereh Komeili Movahed, Parvaneh Jafar. Biogenic copper oxide nanoparticles from Bacillus coagulans induced reactive oxygen species generation and apoptotic and anti-metastatic activities in breast cancer cells. Scientific reports. vol 13. issue 1. 2023-02-24. PMID:36828883. |
the up-regulation of bcl2-associated x (bax), cyclin dependent kinase inhibitor 1a (p21), caspase 3 (casp3), and caspase 9 (casp9), the down-regulation of bcl2 apoptosis regulator (bcl2), annexin v-fitc/propidium iodide, and reactive oxygen species (ros) generation results suggested that bc-cuonps had a significant apoptotic impact when compared to the control. |
2023-02-24 |
2023-08-14 |
human |