| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rachel Thijssen, Luyi Tian, Mary Ann Anderson, Christoffer Flensburg, Andrew Jarratt, Alexandra L Garnham, Jafar S Jabbari, Hongke Peng, Thomas E Lew, Charis E Teh, Quentin Gouil, Angela Georgiou, Tania Tan, Tirta M Djajawi, Constantine S Tam, John F Seymour, Piers Blombery, Daniel H D Gray, Ian J Majewski, Matthew E Ritchie, Andrew W Roberts, David Ching Siang Huan. Single-cell multiomics reveal the scale of multi-layered adaptations enabling CLL relapse during venetoclax therapy. Blood. 2022-06-16. PMID:35709339. |
one layer comprises changes in the bcl2 family of apoptosis regulators, especially the pro-survival family members. |
2022-06-16 |
2023-08-14 |
Not clear |
| Ngoc Tuan Tran, Yanlian Zhou, Lianjie Chen, Zaiqiao Sun, Shengkang L. SpBNIP3 regulates apoptosis and autophagy in mud crab (Scylla paramamosain) during white spot syndrome virus infection. Developmental and comparative immunology. 2022-06-11. PMID:35690229. |
bnip3 (bcl2 and adenovirus e1b 19-kda-interacting protein 3), which is a pro-apoptotic protein in the bcl-2 family involves a variety of cell signaling pathways, including mitochondrial dysfunction, mitochondrial autophagy, and apoptosis in vertebrates. |
2022-06-11 |
2023-08-14 |
Not clear |
| Sara Mirzaei, Milad Iranshahy, Hamid Gholamhosseinian, Maryam M Matin, Fatemeh B Rassoul. Urolithins increased anticancer effects of chemical drugs, ionizing radiation and hyperthermia on human esophageal carcinoma cells in vitro. Tissue & cell. vol 77. 2022-06-09. PMID:35679683. |
to further elucidate the effects of ua, we used flow cytometry for investigation of induced apoptosis, and qrt-pcr for evaluating changes in the expression of hsp27, ccnd1 and bcl2. |
2022-06-09 |
2023-08-14 |
human |
| Chaohui Zhang, Lin Chen, Qiang Bai, Lina Wang, Siheng Li, Ning Sui, Dongqin Yang, Zhiling Zh. Nonmetal Graphdiyne Nanozyme-Based Ferroptosis-Apoptosis Strategy for Colon Cancer Therapy. ACS applied materials & interfaces. 2022-06-08. PMID:35674241. |
a metal-free ferroptosis-apoptosis inducer was reported based on boron and nitrogen codoped graphdiyne (bn-gdy) that possesses efficient glutathione (gsh) depletion capability and concurrently induces ferroptosis by deactivation of gsh-dependent peroxidases 4 (gpx4) and apoptosis by downregulation of bcl2. |
2022-06-08 |
2023-08-14 |
Not clear |
| Thomas E Lew, John F Seymou. Clinical experiences with venetoclax and other pro-apoptotic agents in lymphoid malignancies: lessons from monotherapy and chemotherapy combination. Journal of hematology & oncology. vol 15. issue 1. 2022-06-06. PMID:35659041. |
bh3-mimetics are a novel drug class of small molecule inhibitors of bcl2 family proteins which restore apoptosis in malignant cells. |
2022-06-06 |
2023-08-14 |
Not clear |
| Wenting Liu, Liping Cheng, Xuefei Li, Lili Zhao, Xiaorong Hu, Zhaocheng M. Short-term pretreatment of naringin isolated from Citrus wilsonii Tanaka attenuates rat myocardial ischemia/reperfusion injury. Naunyn-Schmiedeberg's archives of pharmacology. 2022-06-06. PMID:35666279. |
additionally, naringin pretreatment exhibited striking decreases in the apoptosis index and downregulation of the protein expression levels of cleaved-caspase3, bcl2 and bax. |
2022-06-06 |
2023-08-14 |
rat |
| Long Zhang, Wan Zhang, Hang Peng, Tianli Shen, Min Wang, Meng Luo, Xiaoyan Qu, Fengyi Qu, Wenguang Liu, Bo Lei, Shuanying Yan. Bioactive cytomembrane@poly(citrate-peptide)-miRNA365 nanoplatform with immune escape and homologous targeting for colon cancer therapy. Materials today. Bio. vol 15. 2022-05-27. PMID:35620794. |
pcp could efficiently deliver mir365 mimic into mc38 cancer cells, promote the apoptosis of mc38 tumor cells and regulate the expression of bcl2 and ki67 |
2022-05-27 |
2023-08-13 |
Not clear |
| Soyoung Kim, Jaeseok Han, Young-Ho Ahn, Chang Hoon Ha, Jung Jin Hwang, Sang-Eun Lee, Jae-Joong Kim, Nayoung Ki. Protective Role of miR-34c in Hypoxia by Activating Autophagy through BCL2 Repression. Molecules and cells. 2022-05-25. PMID:35611688. |
mir-34c directly inhibited bcl2 expression, acting as a toggle switch between apoptosis and autophagy |
2022-05-25 |
2023-08-13 |
human |
| Haoyang Zhou, Dafeng Yang, Henry S Cheng, Michael G McCoy, Daniel Pérez-Cremades, Stefan Haemmig, Danny Wong, Lei Chen, Mark W Feinber. miR-181b regulates vascular endothelial aging by modulating an MAP3K3 signaling pathway. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36. issue 6. 2022-05-20. PMID:35593587. |
in gain- or loss-of-function studies, mir-181b regulated the expression of key apoptosis markers (bcl2, bax, cleaved-caspase3) and senescence markers (p16, p21, γh2ax) and the ratio of apoptotic cells (tunel-positive) and senescent cells (sa-βgal-positive) in h |
2022-05-20 |
2023-08-13 |
Not clear |
| Wenlong Huang, Jiefeng Xiao, Xiaoling Shi, Shukai Zheng, Haiyi Li, Caixia Liu, Kusheng W. Effects of di-(2-ethylhexyl) phthalate (DEHP) on behavior and dopamine signaling in zebrafish (Danio rerio). Environmental toxicology and pharmacology. 2022-05-20. PMID:35595013. |
meanwhile, behavioral changes were accompanied by increased apoptosis and malondialdehyde (mda) content, decreased superoxide dismutase (sod) activity and dopamine (da) content, and perturbed the expression of genes associated with the synthesis (th), reuptake (dat) and metabolism (mao) of da, with dopamine receptors (drs), and with the apoptosis pathway (p53, bax, bcl2, caspase-3, caspase-8, caspase-9). |
2022-05-20 |
2023-08-13 |
zebrafish |
| Xiaowei Qin, Wenqing Dang, Xiaofeng Yang, Kai Wang, Ermias Kebreab, Lihua Ly. Neddylation inactivation affects cell cycle and apoptosis in sheep follicular granulosa cells. Journal of cellular physiology. 2022-05-17. PMID:35578798. |
meanwhile, the b-cell lymphoma/leukemia 2 (bcl2) family members bcl-2 and mcl-1 were downregulated, subsequently inducing apoptosis in follicular gcs of sheep. |
2022-05-17 |
2023-08-13 |
Not clear |
| Irene Sánchez-Ajofrín, Patricia Peris-Frau, Olga García-Álvarez, María Del Rocío Fernández-Santos, Vidal Montoro, José Julián Garde, Ana Josefa Sole. Serum supplementation during in vitro fertilization of sheep oocytes influences blastocyst quality through the differential abundance of mRNA transcripts. Reproduction in domestic animals = Zuchthygiene. 2022-05-16. PMID:35575960. |
nonetheless, in vitro-produced blastocysts from the 10% ess treatment showed a higher transcript abundance of mrnas involved in apoptosis (itm2b and bcl2), antioxidant defense (gpx1), and growth-related imprinting (igf2r). |
2022-05-16 |
2023-08-13 |
Not clear |
| Ajay K Yadav, Teja Naveen Sata, Daksh Verma, Amit K Mishra, Amrendra K Sah, Md Musa Hossain, Kishor Pant, Senthil K Venugopa. Free fatty acid-induced miR-181a-5p stimulates apoptosis by targeting XIAP and Bcl2 in hepatic cells. Life sciences. 2022-05-13. PMID:35551953. |
free fatty acid-induced mir-181a-5p stimulates apoptosis by targeting xiap and bcl2 in hepatic cells. |
2022-05-13 |
2023-08-13 |
Not clear |
| Ajay K Yadav, Teja Naveen Sata, Daksh Verma, Amit K Mishra, Amrendra K Sah, Md Musa Hossain, Kishor Pant, Senthil K Venugopa. Free fatty acid-induced miR-181a-5p stimulates apoptosis by targeting XIAP and Bcl2 in hepatic cells. Life sciences. 2022-05-13. PMID:35551953. |
in this study, we showed that free fatty acids stimulate apoptosis by upregulating mir-181a-5p expression, which in turn targets xiap and bcl2. |
2022-05-13 |
2023-08-13 |
Not clear |
| Vrutti V Mehta, Kenza E Benzeroua. Cucurbitacin B and Evodiamine imparts anti-neoplastic effects against Glioblastoma Multiforme via PI3-K/AKT signaling pathway. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35557445. |
in addition, cells treated with cub and evo showed a decrease in bcl2, an anti-apoptotic factor, and an increase in bax, a pro-apoptotic factor, expression; a hallmark of induction of apoptosis. |
2022-05-13 |
2023-08-13 |
human |
| Kai Wang, Jing Dai, Tao Liu, Qiong Wang, Yingxu Pan. Retracted Article: LncRNA ZEB2-AS1 regulates the drug resistance of acute myeloid leukemia RSC advances. vol 9. issue 67. 2022-05-11. PMID:35540690. |
western blotting was applied to analyze levels of bcl2 apoptosis regulator (bcl-2), bcl2 associated x, apoptosis regulator (bax), cleaved-caspase-3 and inpp4b. |
2022-05-11 |
2023-08-13 |
Not clear |
| An-Qi Zhang, Lu Wang, Yi-Xiu Wang, Shan-Shan Hong, Yu-Shan Zhong, Ru-Yi Yu, Xin-Lu Wu, Bing-Bing Zhou, Qi-Min Yu, Hai-Feng Fu, Shuang-Dong Chen, Yun-Chang Mo, Qin-Xue Dai, Jun-Lu Wan. Silencing miRNA-324-3p protects against cerebral ischemic injury via regulation of the GATA2/A1R axis. Neural regeneration research. vol 17. issue 11. 2022-05-10. PMID:35535903. |
in a pc12 cell oxygen-glucose deprivation/reoxygenation model, a mir-324-3p mimic decreased cell viability and expression of the anti-apoptotic protein bcl2 and increased expression of the pro-apoptotic protein bax and rates of cell apoptosis, whereas treatment with a mir-324-3p inhibitor had the opposite effects. |
2022-05-10 |
2023-08-13 |
rat |
| Xiangyun Zhu, Dechen Liu, Guoqing Li, Mengmeng Zhi, Ji Sun, Liang Qi, Jingbo Li, Stephen J Pandol, Ling L. Exosomal miR-140-3p and miR-143-3p from TGF-β1-treated pancreatic stellate cells target BCL2 mRNA to increase β-cell apoptosis. Molecular and cellular endocrinology. 2022-05-05. PMID:35513284. |
exosomal mir-140-3p and mir-143-3p from tgf-β1-treated pancreatic stellate cells target bcl2 mrna to increase β-cell apoptosis. |
2022-05-05 |
2023-08-13 |
Not clear |
| E A Klimov, V V Sobolev, N A Batashkov, Z G Kokaeva, A V Tretiakov, Z A Nevozinskaya, I M Korsunskaya, T N Sukhova, O E Evina, A Z Khashukoev. Transcriptional Activity of Some Genes Involved in Apoptosis in Patients with Vulvar Lichen Sclerosus. Bulletin of experimental biology and medicine. 2022-05-02. PMID:35501640. |
we assessed the level of transcriptional activity of apaf1, bax, bcl2, birc5, ccnd1, dapk1, mcl1, and myc genes encoding products that control apoptosis in the samples of tissues affected by vulvar lichen sclerosus and adjacent control tissues (n=24). |
2022-05-02 |
2023-08-13 |
Not clear |
| Doneti Ravinder, Shailima Rampogu, Gangappa Dharmapuri, Akbar Pasha, Keun Woo Lee, Smita C Pawa. Inhibition of DDX3 and COX-2 by forskolin and evaluation of anti-proliferative, pro-apoptotic effects on cervical cancer cells: molecular modelling and in vitro approaches. Medical oncology (Northwood, London, England). vol 39. issue 5. 2022-04-28. PMID:35478276. |
the fsk treatment also significantly induced apoptosis in cancer cells by modulating the expression of apoptotic markers like caspase-3, cleaved caspase-3, caspase-9, cleaved caspase-9, full length-poly adp ribose polymerase (parp), cleaved-poly adp ribose polymerase (c-parp) and bcl2 in dose dependent manner. |
2022-04-28 |
2023-08-13 |
Not clear |