| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dong Chen, Xin Jian. Exosomes-derived miR-125-5p from cartilage endplate stem cells regulates autophagy and ECM metabolism in nucleus pulposus by targeting SUV38H1. Experimental cell research. 2022-03-01. PMID:35231441. |
n-cesc-exo reduced degenerated nucleus pulposus cells (tbhp-npc) apoptosis, bax, mmp13, and p62 expression, while increased bcl2, acan, lc3-ii/i expression, and the fluorescence intensity of gfp-lc3. |
2022-03-01 |
2023-08-13 |
Not clear |
| Xiaoli Yin, Yinghao Ren, Weitao Luo, Meiqiu Liao, Lin Huang, Xueqi Zhuang, Yuan Liu, Weina Wan. Nemo-like kinase (NLK) gene regulates apoptosis via the p53 signaling pathway in Litopenaeus vannamei under low-temperature stress. Developmental and comparative immunology. 2022-03-01. PMID:35231467. |
meanwhile, the bcl2 apoptosis regulator (bcl-2), mdm2 proto-oncogene (mdm2), and yin yang 1 (yy1) were upregulated. |
2022-03-01 |
2023-08-13 |
Not clear |
| Mohammad Almasri, Marah Amer, Joseph Ghanej, Abdurraouf Mokhtar Mahmoud, Gianluca Gaidano, Riccardo Moi. Druggable Molecular Pathways in Chronic Lymphocytic Leukemia. Life (Basel, Switzerland). vol 12. issue 2. 2022-02-25. PMID:35207569. |
moreover, the restoration of apoptosis by the bcl2 inhibitor venetoclax offers meaningful clinical activity with a fixed-duration scheme. |
2022-02-25 |
2023-08-13 |
Not clear |
| Pradip Kumar Jaiswara, Ajay Kuma. Nimbolide retards T cell lymphoma progression by altering apoptosis, glucose metabolism, pH regulation, and ROS homeostasis. Environmental toxicology. 2022-02-24. PMID:35199915. |
we noticed significantly augmented apoptosis in nimbolide- administered tumor-bearing mice, possibly due to down-regulated expression of bcl2 and up-regulated expression of p53, cleaved caspase-3, cyt c, and ros. |
2022-02-24 |
2023-08-13 |
mouse |
| Fazul Nabi, Weilai Tao, Ruiling Ye, Zhenzhen Li, Qin Lu, Yangfei Shang, Yu Hu, Jiali Fang, Zohaib Ahmed Bhutto, Juan Li. Penthorum Chinense Pursh Extract Alleviates Aflatoxin B1-Induced Liver Injury and Oxidative Stress Through Mitochondrial Pathways in Broilers. Frontiers in veterinary science. vol 9. 2022-02-21. PMID:35187148. |
furthermore, supplementation of pcpe to the afb1 group reversed apoptosis by significantly down-regulating the mrna expression levels of bax, bak, caspase-9, caspase-3, and p53 and up-regulating the expression levels of bcl2 in the liver of broilers. |
2022-02-21 |
2023-08-13 |
Not clear |
| Anas Taha, Stephanie Taha-Mehlitz, Stephanie Petzold, Sergey L Achinovich, Dmitry Zinovkin, Bassey Enodien, Md Zahidul I Pranjol, Eldar A Nadyro. Prognostic Value of Immunohistochemical Markers for Locally Advanced Rectal Cancer. Molecules (Basel, Switzerland). vol 27. issue 3. 2022-02-15. PMID:35163861. |
the aim of this study is to reveal the potential roles of apoptosis markers (bcl2 and p53), proliferation markers (ki-67 and cycld1), and the neuroendocrine marker chromogranin a as markers for the radioresistance of rectal cancer. |
2022-02-15 |
2023-08-13 |
Not clear |
| Maryam Farzaneh Behelgardi, Zahra Gholami Shahvir, S Mohsen Asghar. Apoptosis induction in human lung and colon cancer cells via impeding VEGF signaling pathways. Molecular biology reports. 2022-02-10. PMID:35142981. |
encouragingly, significant downregulation of b-cell lymphoma 2 (bcl2), x-linked inhibitor of apoptosis, procaspase9, and procaspase3, as well as upregulation of pten and p53 tumor suppressors, bcl2 associated x, cytochrome c, cleaved caspase9, and cleaved caspase3 in vgb4-treated a549 and ht29 cells, further confirmed the profound inductive influence of vgb4 on apoptotic pathways. |
2022-02-10 |
2023-08-13 |
human |
| Jian Kang, Yan Gu. Human Umbilical Cord Mesenchymal Stem Cells Derived Exosomes Promote Neurological Function Recovery in a Rat Spinal Cord Injury Model. Neurochemical research. 2022-02-08. PMID:35132478. |
intravenous administration of huc-msc derived exosomes dramatically improved motor function of sprague-dawley rats after sci, with reduced apoptosis demonstrated by increased expression of b-cell lymphoma 2 (bcl2), decreased bcl2 associated x, apoptosis regulator (bax), and reduced cleaved caspase 9. |
2022-02-08 |
2023-08-13 |
human |
| Huixin Gao, Yuxia Lin, Changbai Huang, Xiaobo Li, Michael S Diamond, Chao Liu, Rong Zhang, Ping Zhan. A genome-wide CRISPR screen identifies HuR as a regulator of apoptosis induced by dsRNA and virus. Journal of cell science. 2022-02-03. PMID:35112703. |
moreover, protection from dsrna-induced apoptosis by hur depletion required the presence of bcl2, indicating that the proapoptotic function of hur is executed by suppressing bcl2. |
2022-02-03 |
2023-08-13 |
Not clear |
| Ming Kuang, Hong Zhou, Guiting Zhang, Chao He, Qianqian Wu, Yuye Ya. [Ox-LDL/β2GPI/anti-β2GPI antibody complex promotes apoptosis and inflammatory factors expression in RAW264.7 cells]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 38. issue 1. 2022-01-26. PMID:35078569. |
results ox-ldl/β2gpi/aβ2gpi antibody complex promoted raw264.7 cells' apoptosis, with a decrease in protein bcl2 and an increase in protein cleaved-caspase-3, and enhanced the level of inflammatory factors, while apoptosis and the expression of inflammatory factors were partially reduced when macrophages had been pre-treated with inhibitors. |
2022-01-26 |
2023-08-13 |
Not clear |
| Nehal M El-Deeb, Mai A Abo-Eleneen, Omyma A Awad, Atef M Abo-Shad. Arthrospira platensis-Mediated Green Biosynthesis of Silver Nano-particles as Breast Cancer Controlling Agent: In Vitro and In Vivo Safety Approaches. Applied biochemistry and biotechnology. 2022-01-20. PMID:35048281. |
in addition, a-bio-agnps induced breast cancer cellular apoptosis by downregulating the expression of survivin, mmp7, tgf, and bcl2 genes. |
2022-01-20 |
2023-08-13 |
mouse |
| Zirui Lü, Xiaona Li, Kebin Li, Paola Ripani, Xiaomeng Shi, Fengrong Xu, Mopei Wang, Liangren Zhang, Thomas Brunner, Ping Xu, Yan Ni. Nitazoxanide and related thiazolides induce cell death in cancer cells by targeting the 20S proteasome with novel binding modes. Biochemical pharmacology. 2022-01-15. PMID:35032461. |
many of these aberrant proteins are regulators of cell cycle progression and apoptosis, such as the cyclins, bcl2 family members and nuclear factor of κb (nf-κb). |
2022-01-15 |
2023-08-13 |
Not clear |
| Yige Yu, Xiu Xin, Feifei Ma, Xiaoheng Li, Yiyan Wang, Qiqi Zhu, Haiqiong Chen, Huitao Li, Ren-Shan G. Bisphenol AF blocks Leydig cell regeneration from stem cells in male rats. Environmental pollution (Barking, Essex : 1987). 2022-01-13. PMID:35026324. |
it induced apoptosis and autophagy by increasing the levels of bax, lc3b, and beclin1 and lowering the levels of bcl2 and p62 at 100 and 200 mg/kg. |
2022-01-13 |
2023-08-13 |
rat |
| Zhen Wang, Xiaoyan Du, Daoyang Yu, Yang Yang, Gaoen Ma, Xueli Jia, Lulu Chen. Sufentanil alleviates cerebral ischemia-reperfusion injury by inhibiting inflammation and protecting the blood-brain barrier in rats. European journal of histochemistry : EJH. vol 66. issue 1. 2022-01-12. PMID:35016494. |
finally, we clarified the apoptosis of brain tissue through the tunel staining and the detection of caspase3, bcl2 and bax. |
2022-01-12 |
2023-08-13 |
rat |
| Zhen Wang, Xiaoyan Du, Daoyang Yu, Yang Yang, Gaoen Ma, Xueli Jia, Lulu Chen. Sufentanil alleviates cerebral ischemia-reperfusion injury by inhibiting inflammation and protecting the blood-brain barrier in rats. European journal of histochemistry : EJH. vol 66. issue 1. 2022-01-12. PMID:35016494. |
suf also inhibited caspase3 and bax rats and promoted bcl2 in mcao rats, thus inhibiting cell apoptosis. |
2022-01-12 |
2023-08-13 |
rat |
| Juan-Juan Li, Mei-Ling Liu, Jia-Ni Lv, Rui-Lin Chen, Ke Ding, Jia-Qi H. Polysaccharides from Platycodonis Radix ameliorated respiratory syncytial virus-induced epithelial cell apoptosis and inflammation through activation of miR-181a-mediated Hippo and SIRT1 pathways. International immunopharmacology. vol 104. 2022-01-09. PMID:34999393. |
mechanistically, prp had the similar effects as mir-181a-5p antagomir on rsv-induced apoptosis and inflammation in hep-2 cells via upregulating bcl2, mll3 and sirt1, which could be reversed by mir-181a-5p mimic. |
2022-01-09 |
2023-08-13 |
mouse |
| Yasmine M Abdel Aziz, Gehad Lotfy, Mohamed M Said, El Sayed H El Ashry, El Sayed H El Tamany, Saied M Soliman, Marwa M Abu-Serie, Mohamed Teleb, Sammer Yousuf, Alexander Dömling, Luis R Domingo, Assem Baraka. Design, Synthesis, Chemical and Biochemical Insights Into Novel Hybrid Spirooxindole-Based p53-MDM2 Inhibitors With Potential Bcl2 Signaling Attenuation. Frontiers in chemistry. vol 9. 2021-12-31. PMID:34970530. |
combination studies disclosed that concomitant administration of bcl2 inhibitors can sensitize the tumor cells and induce apoptosis. |
2021-12-31 |
2023-08-13 |
Not clear |
| Ghasem Majdi Yazdi, Gholamhasan Vaezi, Vida Hojati, Mohammad Mohammad-Zade. The Effect of 6-gingerol on Growth Factors and Apoptosis Indices in Rats Exposed to Gold Nanoparticles. Basic and clinical neuroscience. vol 12. issue 3. 2021-12-17. PMID:34917289. |
given the antioxidant properties of gingerol (ging), this study aimed to determine the protective effect of 6-gingerol on hippocampal levels of brain-derived neurotrophic factor (bdnf), nerve growth factor (ngf), dna oxidative damage, and the amount of bax and bcl2 apoptosis indices of rats exposed to aunps. |
2021-12-17 |
2023-08-13 |
rat |
| Jitrada Phetfong, Tulyapruek Tawonsawatruk, Witchayapon Kamprom, Pawared Ontong, Dalina Tanyong, Suparerk Borwornpinyo, Aungkura Supokawe. Bone marrow mesenchymal stem cell-derived extracellular vesicles affect proliferation and apoptosis of leukemia cells in vitro. FEBS open bio. 2021-12-15. PMID:34907674. |
msc-evs increased the expression of bid and bax and decreased expression of bcl2, indicating the induction of intrinsic apoptosis in nb4. |
2021-12-15 |
2023-08-13 |
Not clear |
| Gerlinde Karbon, Manuel D Haschka, Hubert Hackl, Claudia Soratroi, Lourdes Rocamora-Reverte, Walther Parson, Heidelinde Fiegl, Andreas Villunge. The BH3-only protein NOXA serves as an independent predictor of breast cancer patient survival and defines susceptibility to microtubule targeting agents. Cell death & disease. vol 12. issue 12. 2021-12-14. PMID:34903710. |
sensitivity to mtas is defined by a subset of pro- and anti-apoptotic bcl2 family proteins controlling mitochondrial apoptosis. |
2021-12-14 |
2023-08-13 |
Not clear |