| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dong-Dong Zhao, Jing-Jing Wang, Jun-Juan Fan, Yu Fu, Yi-di Ma, Chen Li, Gao-Feng Wu, Mei Liu, Shu-Mei Lin, Jian-Min H. Taurine Prevents LPS-Induced Liver Injury in Weaned Piglets. Advances in experimental medicine and biology. vol 1370. 2022-07-26. PMID:35882821. |
tunel was used to detect apoptosis, while qpcr was employed to detect ho-1, nrf-2, bcl2, bax, caspase-3, and nf- κb p65 transcriptomic expression levels. |
2022-07-26 |
2023-08-14 |
cat |
| Shadi Kahalian, Maryam Koopaie, Neda Hakimiha, Sajad Kolahdoo. Assessment of the methylene blue mediated photodynamic therapy on Folia medica. vol 64. issue 2. 2022-07-19. PMID:35851773. |
assessment of the methylene blue mediated photodynamic therapy on this study aimed to assess the effect of photodynamic therapy (pdt) on apoptosis of head and neck squamous cell carcinoma (hnscc) cells by flow cytometry and evaluating bax and bcl2 genes expression. |
2022-07-19 |
2023-08-14 |
Not clear |
| Zhi-Chao Luo, Zi-Run Jin, Ya-Fei Jiang, Tian-Jiao Wei, Ya-Lei Cao, Zhe Zhang, Rui Wei, Hui Jian. The protective effects and underlying mechanisms of dapagliflozin on diabetes-induced testicular dysfunction. Asian journal of andrology. 2022-07-18. PMID:35848706. |
we also found that dapagliflozin inhibited the testicular apoptotic process by upregulating the expression of the antiapoptotic protein b-cell lymphoma 2 (bcl2) and x-linked inhibitor of apoptosis protein (xiap) and inhibiting oxidative stress by enhancing the antioxidant status, including total antioxidant capacity, total superoxide dismutase (sod) activity, and glutathione peroxidase (gpx) activity, as well as decreasing the level of 4-hydroxynonenal (4-hne). |
2022-07-18 |
2023-08-14 |
mouse |
| Guowu Hu, Pia J Hauk, Nannan Zhang, Waleed Elsegeiny, Carlos M Guardia, Amy Kullas, Kevin Crosby, Robin R Deterding, Michaela Schedel, Paul Reynolds, Jordan K Abbott, Vijaya Knight, Stefania Pittaluga, Mark Raffeld, Sergio D Rosenzweig, Juan S Bonifacino, Gulbu Uzel, Peter R Williamson, Erwin W Gelfan. Autophagy-associated immune dysregulation and hyperplasia in a patient with compound heterozygous mutations in Autophagy. 2022-07-15. PMID:35838483. |
autophagy-associated immune dysregulation and hyperplasia in a patient with compound heterozygous mutations in bcl2: bcl2 apoptosis regulator; bcl10: bcl10 immune signaling adaptor; card11: caspase recruitment domain family member 11; cbm: card11-bcl10-malt1; cr2: complement c3d receptor 2; ebna: epstein barr nuclear antigen; ebv: epstein-barr virus; fcgr3a; fc gamma receptor iiia; glild: granulomatous-lymphocytic interstitial lung disease; hv: healthy volunteer; ikbkb/ikb kinase: inhibitor of nuclear factor kappa b kinase subunit beta; il2ra: interleukin 2 receptor subunit alpha; malt1: malt1 paracaspase; ms4a1: membrane spanning 4-domain a1; mtor: mechanistic target of rapamycin kinase; myc: myc proto-oncogene, bhlh: transcription factor; ncam1: neural cell adhesion molecule 1; nfkb: nuclear factor kappa b; niaid: national institute of allergy and infectious diseases; nk: natural killer; ptprc: protein tyrosine phosphatase receptor type c; sell: selectin l; pbmcs: peripheral blood mononuclear cells; tr: t cell receptor; tregs: regulatory t cells; wt: wild-type. |
2022-07-15 |
2023-08-14 |
human |
| Nouf M Alyami, Saba Abdi, Hanadi M Alyami, Rafa Almee. Proanthocyanidins alleviate pentylenetetrazole-induced epileptic seizures in mice via the antioxidant activity. Neurochemical research. 2022-07-15. PMID:35838827. |
moreover, neuronal apoptosis was recorded following the development of epileptic convulsions as confirmed by the elevated bax and caspase-3 and the decreased bcl2 protein. |
2022-07-15 |
2023-08-14 |
mouse |
| Hai Duc Nguyen, Min-Sun Ki. The Effects of a Mixture of Cadmium, Lead, and Mercury on Metabolic Syndrome and Its Components, as well as Cognitive Impairment: Genes, MicroRNAs, Transcription Factors, and Sponge Relationships : The Effects of a Mixture of Cadmium, Lead, and Mercury on Metabolic Syndrome and Its Components, as well as Cognitive Impairment: Genes, MicroRNAs, Transcription Factors, and Sponge Relationships. Biological trace element research. 2022-07-07. PMID:35798913. |
the genes casp3, bax, bcl2, il6, tnf, apoe, hmox1, and igf were found to be mutually affected by the heavy metal mixture studied, suggesting the importance of apoptosis, inflammation, lipid, heme, and glucose metabolism in mets and cognitive impairment, as well as the potentiality of targeting these genes in prospective therapeutic intervention for these diseases. |
2022-07-07 |
2023-08-14 |
Not clear |
| Liu Yang, Jingyun Zhang, Xiaoxiao Han, Chenchi Li, Ranyang Liu, Zihua Ma, Bing Han, Rujia Xie, Qin Yan. [Rat serum containing oxymatrine inhibits the proliferation of LX2 human hepatic stellate cells induced by sodium arsenite via blocking PI3K/AKT pathway]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 38. issue 7. 2022-07-05. PMID:35786453. |
results after indirect arsenic treatment, the proliferation rate of lx2 cells increased, the proportion of g1 phase decreased, the proportion of apoptosis decreased, the expression of α-sma, pi3k, p-akt, cyclin d1, bcl2 were significantly up-regulated, and the expression of bax decreased. |
2022-07-05 |
2023-08-14 |
human |
| Wang Peipei, Wang Ping, Yin Miaomiao, Wang Shu. Sevoflurane ameliorates LPS-induced inflammatory injury of HK-2 cells through Sirtuin1/NF-κB pathway. Allergologia et immunopathologia. vol 50. issue 4. 2022-07-05. PMID:35789410. |
our results demonstrated that lps caused decreased cell viability, increased ldh release, improved cell apoptosis along with decreased expression of bcl2 and enhanced expressions of bax, cleaved parp and cleaved caspase, enhanced production, and protein expressions of tnf-α, il-6, and il-1β, increased generation of reactive oxygen species (ros) and malondialdehyde (mda), but contributed to declined activity of superoxide dismutase (sod) and glutathione peroxidase (gsh-px). |
2022-07-05 |
2023-08-14 |
human |
| Chengtao Sun, Mengzhen Li, Lian Zhang, Feifei Sun, Huimou Chen, Yanjie Xu, Yingxia Lan, Li Zhang, Suying Lu, Jia Zhu, Junting Huang, Juan Wang, Yang Hu, Yanfen Feng, Yizhuo Zhan. IDO1 plays a tumor-promoting role via MDM2-mediated suppression of the p53 pathway in diffuse large B-cell lymphoma. Cell death & disease. vol 13. issue 6. 2022-06-27. PMID:35760783. |
ido1 inhibition induced cell apoptosis coupled with puma and bax upregulation, as well as bcl2 and bcl-xl downregulation. |
2022-06-27 |
2023-08-14 |
Not clear |
| Rachel Thijssen, Luyi Tian, Mary Ann Anderson, Christoffer Flensburg, Andrew Jarratt, Alexandra L Garnham, Jafar S Jabbari, Hongke Peng, Thomas E Lew, Charis E Teh, Quentin Gouil, Angela Georgiou, Tania Tan, Tirta M Djajawi, Constantine S Tam, John F Seymour, Piers Blombery, Daniel H D Gray, Ian J Majewski, Matthew E Ritchie, Andrew W Roberts, David Ching Siang Huan. Single-cell multiomics reveal the scale of multi-layered adaptations enabling CLL relapse during venetoclax therapy. Blood. 2022-06-16. PMID:35709339. |
venetoclax inhibits the pro-survival protein bcl2 to induce apoptosis and is a standard therapy for chronic lymphocytic leukemia (cll), delivering high complete remission rates and prolonged progression-free survival in relapsed cll, but with eventual loss of efficacy. |
2022-06-16 |
2023-08-14 |
Not clear |
| Rachel Thijssen, Luyi Tian, Mary Ann Anderson, Christoffer Flensburg, Andrew Jarratt, Alexandra L Garnham, Jafar S Jabbari, Hongke Peng, Thomas E Lew, Charis E Teh, Quentin Gouil, Angela Georgiou, Tania Tan, Tirta M Djajawi, Constantine S Tam, John F Seymour, Piers Blombery, Daniel H D Gray, Ian J Majewski, Matthew E Ritchie, Andrew W Roberts, David Ching Siang Huan. Single-cell multiomics reveal the scale of multi-layered adaptations enabling CLL relapse during venetoclax therapy. Blood. 2022-06-16. PMID:35709339. |
one layer comprises changes in the bcl2 family of apoptosis regulators, especially the pro-survival family members. |
2022-06-16 |
2023-08-14 |
Not clear |
| Ngoc Tuan Tran, Yanlian Zhou, Lianjie Chen, Zaiqiao Sun, Shengkang L. SpBNIP3 regulates apoptosis and autophagy in mud crab (Scylla paramamosain) during white spot syndrome virus infection. Developmental and comparative immunology. 2022-06-11. PMID:35690229. |
bnip3 (bcl2 and adenovirus e1b 19-kda-interacting protein 3), which is a pro-apoptotic protein in the bcl-2 family involves a variety of cell signaling pathways, including mitochondrial dysfunction, mitochondrial autophagy, and apoptosis in vertebrates. |
2022-06-11 |
2023-08-14 |
Not clear |
| Sara Mirzaei, Milad Iranshahy, Hamid Gholamhosseinian, Maryam M Matin, Fatemeh B Rassoul. Urolithins increased anticancer effects of chemical drugs, ionizing radiation and hyperthermia on human esophageal carcinoma cells in vitro. Tissue & cell. vol 77. 2022-06-09. PMID:35679683. |
to further elucidate the effects of ua, we used flow cytometry for investigation of induced apoptosis, and qrt-pcr for evaluating changes in the expression of hsp27, ccnd1 and bcl2. |
2022-06-09 |
2023-08-14 |
human |
| Chaohui Zhang, Lin Chen, Qiang Bai, Lina Wang, Siheng Li, Ning Sui, Dongqin Yang, Zhiling Zh. Nonmetal Graphdiyne Nanozyme-Based Ferroptosis-Apoptosis Strategy for Colon Cancer Therapy. ACS applied materials & interfaces. 2022-06-08. PMID:35674241. |
a metal-free ferroptosis-apoptosis inducer was reported based on boron and nitrogen codoped graphdiyne (bn-gdy) that possesses efficient glutathione (gsh) depletion capability and concurrently induces ferroptosis by deactivation of gsh-dependent peroxidases 4 (gpx4) and apoptosis by downregulation of bcl2. |
2022-06-08 |
2023-08-14 |
Not clear |
| Thomas E Lew, John F Seymou. Clinical experiences with venetoclax and other pro-apoptotic agents in lymphoid malignancies: lessons from monotherapy and chemotherapy combination. Journal of hematology & oncology. vol 15. issue 1. 2022-06-06. PMID:35659041. |
bh3-mimetics are a novel drug class of small molecule inhibitors of bcl2 family proteins which restore apoptosis in malignant cells. |
2022-06-06 |
2023-08-14 |
Not clear |
| Wenting Liu, Liping Cheng, Xuefei Li, Lili Zhao, Xiaorong Hu, Zhaocheng M. Short-term pretreatment of naringin isolated from Citrus wilsonii Tanaka attenuates rat myocardial ischemia/reperfusion injury. Naunyn-Schmiedeberg's archives of pharmacology. 2022-06-06. PMID:35666279. |
additionally, naringin pretreatment exhibited striking decreases in the apoptosis index and downregulation of the protein expression levels of cleaved-caspase3, bcl2 and bax. |
2022-06-06 |
2023-08-14 |
rat |
| Long Zhang, Wan Zhang, Hang Peng, Tianli Shen, Min Wang, Meng Luo, Xiaoyan Qu, Fengyi Qu, Wenguang Liu, Bo Lei, Shuanying Yan. Bioactive cytomembrane@poly(citrate-peptide)-miRNA365 nanoplatform with immune escape and homologous targeting for colon cancer therapy. Materials today. Bio. vol 15. 2022-05-27. PMID:35620794. |
pcp could efficiently deliver mir365 mimic into mc38 cancer cells, promote the apoptosis of mc38 tumor cells and regulate the expression of bcl2 and ki67 |
2022-05-27 |
2023-08-13 |
Not clear |
| Soyoung Kim, Jaeseok Han, Young-Ho Ahn, Chang Hoon Ha, Jung Jin Hwang, Sang-Eun Lee, Jae-Joong Kim, Nayoung Ki. Protective Role of miR-34c in Hypoxia by Activating Autophagy through BCL2 Repression. Molecules and cells. 2022-05-25. PMID:35611688. |
mir-34c directly inhibited bcl2 expression, acting as a toggle switch between apoptosis and autophagy |
2022-05-25 |
2023-08-13 |
human |
| Haoyang Zhou, Dafeng Yang, Henry S Cheng, Michael G McCoy, Daniel Pérez-Cremades, Stefan Haemmig, Danny Wong, Lei Chen, Mark W Feinber. miR-181b regulates vascular endothelial aging by modulating an MAP3K3 signaling pathway. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36. issue 6. 2022-05-20. PMID:35593587. |
in gain- or loss-of-function studies, mir-181b regulated the expression of key apoptosis markers (bcl2, bax, cleaved-caspase3) and senescence markers (p16, p21, γh2ax) and the ratio of apoptotic cells (tunel-positive) and senescent cells (sa-βgal-positive) in h |
2022-05-20 |
2023-08-13 |
Not clear |
| Wenlong Huang, Jiefeng Xiao, Xiaoling Shi, Shukai Zheng, Haiyi Li, Caixia Liu, Kusheng W. Effects of di-(2-ethylhexyl) phthalate (DEHP) on behavior and dopamine signaling in zebrafish (Danio rerio). Environmental toxicology and pharmacology. 2022-05-20. PMID:35595013. |
meanwhile, behavioral changes were accompanied by increased apoptosis and malondialdehyde (mda) content, decreased superoxide dismutase (sod) activity and dopamine (da) content, and perturbed the expression of genes associated with the synthesis (th), reuptake (dat) and metabolism (mao) of da, with dopamine receptors (drs), and with the apoptosis pathway (p53, bax, bcl2, caspase-3, caspase-8, caspase-9). |
2022-05-20 |
2023-08-13 |
zebrafish |