| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nadia Fattahi, Abbas Bahari, Ali Ramazani, Davoud Koolivan. In vitro immunobiological assays of methotrexate-stearic acid conjugate in human PBMCs. Immunobiology. vol 225. issue 5. 2021-11-04. PMID:32962811. |
the expression of four key genes involved in inflammation and apoptosis including il-8, il-1β, il-10 and bcl2 depicted that the mtx-sa had controversial behavior in different doses on the inflammatory transcription. |
2021-11-04 |
2023-08-13 |
human |
| Shivangi Sharma, Kontham Kulangara Varsha, Ujjayinee Ray, Humaira Siddiqua, Anjana Elizabeth Jose, Sridhar Muninarasimaiah, Sathees C Raghavan, Bibha Choudhar. Acute toxicity analysis of an inhibitor of BCL2, Disarib, in rats. Scientific reports. vol 11. issue 1. 2021-11-04. PMID:33976278. |
bcl2 family proteins are known to play a vital role in the regulation of apoptosis. |
2021-11-04 |
2023-08-13 |
mouse |
| Angel Y F Kam, Sadhna O Piryani, Chang-Lung Lee, David A Rizzieri, Neil L Spector, Stefanie Sarantopoulos, Phuong L Doa. Selective ERBB2 and BCL2 Inhibition Is Synergistic for Mitochondrial-Mediated Apoptosis in MDS and AML Cells. Molecular cancer research : MCR. vol 19. issue 5. 2021-11-02. PMID:33514658. |
selective erbb2 and bcl2 inhibition is synergistic for mitochondrial-mediated apoptosis in mds and aml cells. |
2021-11-02 |
2023-08-13 |
Not clear |
| Sergio Castro-Gonzalez, Sydney Simpson, Yuhang Shi, Yuexuan Chen, Jared Benjamin, Ruth Serra-Moren. HIV Nef-mediated Ubiquitination of BCL2: Implications in Autophagy and Apoptosis. Frontiers in immunology. vol 12. 2021-11-01. PMID:34025682. |
hiv nef-mediated ubiquitination of bcl2: implications in autophagy and apoptosis. |
2021-11-01 |
2023-08-13 |
Not clear |
| Sergio Castro-Gonzalez, Sydney Simpson, Yuhang Shi, Yuexuan Chen, Jared Benjamin, Ruth Serra-Moren. HIV Nef-mediated Ubiquitination of BCL2: Implications in Autophagy and Apoptosis. Frontiers in immunology. vol 12. 2021-11-01. PMID:34025682. |
importantly, both mitochondrial bcl2 and prkn are tightly connected to mitochondrial function and apoptosis. |
2021-11-01 |
2023-08-13 |
Not clear |
| Sergio Castro-Gonzalez, Sydney Simpson, Yuhang Shi, Yuexuan Chen, Jared Benjamin, Ruth Serra-Moren. HIV Nef-mediated Ubiquitination of BCL2: Implications in Autophagy and Apoptosis. Frontiers in immunology. vol 12. 2021-11-01. PMID:34025682. |
hence, by enhancing the prkn-mediated ubiquitination of bcl2 at the mitochondria, hiv might promote apoptosis. |
2021-11-01 |
2023-08-13 |
Not clear |
| S J Tong, X Y Zhang, H F Guo, J Yang, Y P Qi, S L. Study on effects of miR-141-3p in proliferation, migration, invasion and apoptosis of colon cancer cells by inhibiting Bcl2. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico. vol 23. issue 12. 2021-11-01. PMID:34086253. |
study on effects of mir-141-3p in proliferation, migration, invasion and apoptosis of colon cancer cells by inhibiting bcl2. |
2021-11-01 |
2023-08-13 |
Not clear |
| Nada F Abo El-Magd, Hasnaa Ali Ebrahim, Mohamed El-Sherbiny, Nada H Eis. Quinacrine Ameliorates Cisplatin-Induced Renal Toxicity via Modulation of Sirtuin-1 Pathway. International journal of molecular sciences. vol 22. issue 19. 2021-11-01. PMID:34639002. |
moreover, quinacrine significantly blocked cisplatin-induced apoptosis, which was made evident by downregulating renal apoptotic proteins (bax and p53) and upregulating the renal anti-apoptotic protein bcl2, compared with the cisplatin group. |
2021-11-01 |
2023-08-13 |
rat |
| Cheng Wang, Changxi Qi, Mingchao Liu, Lumei Wang, Guodong Cheng, Liping Li, Yuxiao Xing, Xiaona Zhao, Jianzhu Li. Protective effects of agrimonolide on hypoxia-induced H9c2 cell injury by maintaining mitochondrial homeostasis. Journal of cellular biochemistry. 2021-11-01. PMID:34724244. |
am inhibited the rate of apoptosis by regulating the expression of apoptosis-related proteins, reducing the level of cleaved caspase 3 and bax, and increasing the level of bcl2, thereby protecting h9c2 cells from hypoxia-induced apoptosis. |
2021-11-01 |
2023-08-13 |
Not clear |
| Yu Wang, Liming Zhu, Mei Guo, Gang Sun, Kun Zhou, Wenjing Pang, Dachun Cao, Xin Tang, Xiangjun Men. Correction to: Histone methyltransferase WHSC1 inhibits colorectal cancer cell apoptosis via targeting anti-apoptotic BCL2. Cell death discovery. vol 7. issue 1. 2021-10-26. PMID:34675194. |
correction to: histone methyltransferase whsc1 inhibits colorectal cancer cell apoptosis via targeting anti-apoptotic bcl2. |
2021-10-26 |
2023-08-13 |
Not clear |
| Hamad Mohammed AbuZahra, Peramaiyan Rajendran, Mohammad Bani Ismai. Zerumbone Exhibit Protective Effect against Zearalenone Induced Toxicity via Ameliorating Inflammation and Oxidative Stress Induced Apoptosis. Antioxidants (Basel, Switzerland). vol 10. issue 10. 2021-10-26. PMID:34679730. |
furthermore, zer increasingly activated bcl2 and suppressed apoptosis marker proteins. |
2021-10-26 |
2023-08-13 |
mouse |
| Yu Feng, Hantao Wang, Zhi Chen, Bin Che. High glucose mediates the ChREBP/p300 transcriptional complex to activate proapoptotic genes Puma and BAX and contributes to intervertebral disc degeneration. Bone. vol 153. 2021-10-25. PMID:34461288. |
using a microarray assay to detect the dysregulated genes in idd patients with obesity, we identified 33 differentially expressed genes and verified only two proapoptotic genes, including puma (p53 upregulated modulator of apoptosis) and bax (bcl2 associated x) responded to glucose. |
2021-10-25 |
2023-08-13 |
rat |
| Yu Wang, Liming Zhu, Mei Guo, Gang Sun, Kun Zhou, Wenjing Pang, Dachun Cao, Xin Tang, Xiangjun Men. Histone methyltransferase WHSC1 inhibits colorectal cancer cell apoptosis via targeting anti-apoptotic BCL2. Cell death discovery. vol 7. issue 1. 2021-10-23. PMID:33469000. |
histone methyltransferase whsc1 inhibits colorectal cancer cell apoptosis via targeting anti-apoptotic bcl2. |
2021-10-23 |
2023-08-13 |
Not clear |
| Jacky Bhagat, Liqing Zang, Hiroko Nakayama, Norihiro Nishimura, Yasuhito Shimad. Effects of nanoplastic on toxicity of azole fungicides (ketoconazole and fluconazole) in zebrafish embryos. The Science of the total environment. vol 800. 2021-10-22. PMID:34399343. |
we investigated the effects of polystyrene (ps) np on the toxicity of ketoconazole (kcz) and fluconazole (fcz) in zebrafish embryos using the developmental toxicity, oxidative-stress-related biochemical parameters, and expression of genes related to neurotoxicity (ache), cardiotoxicity (gata4, bmp4), inflammation (il1b), oxidative stress (sod1, sod2, cyp1a), and apoptosis (bax, bcl2). |
2021-10-22 |
2023-08-13 |
zebrafish |
| Yan Li, Xiaolin Zhang, Yuanyuan Wei, Shujuan Wen, Xing Lin, Quanfang Huan. [Tormentic acid inhibits proliferation and promotes apoptosis of LX-2 human hepatic stellate cells via blocking NF-κB signaling pathway]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 37. issue 10. 2021-10-22. PMID:34670666. |
ta significantly induced lx-2 cells apoptosis by down-regulating the expression of the anti-apoptotic protein bcl2 and up-regulating the expression of the pro-apoptotic protein bax. |
2021-10-22 |
2023-08-13 |
human |
| Robert G Hawley, Yuzhong Chen, Irene Riz, Chen Zen. An Integrated Bioinformatics and Computational Biology Approach Identifies New BH3-Only Protein Candidates. The open biology journal. vol 5. 2021-10-21. PMID:22754595. |
in particular, the analysis strongly suggests that the apoptosis inhibitor and dna damage response regulator, aven, which was originally isolated as a bcl-xl-interacting protein, is a functional bh3-only protein representing a distinct subclass of bcl2 family members. |
2021-10-21 |
2023-08-12 |
Not clear |
| Aruna Basu, Xin Jiang, Massimo Negrini, Subrata Halda. MicroRNA-mediated regulation of pancreatic cancer cell proliferation. Oncology letters. vol 1. issue 3. 2021-10-21. PMID:22966344. |
the overall objective of our investigation was to assess whether mirna-16 (mir-16) is involved in the regulation of critical genes, such as bcl2, that control the sensitivity of pancreatic cancer cells to apoptosis. |
2021-10-21 |
2023-08-12 |
human |
| Yangjun Gao, Hong Wu, Dongmei He, Xiaomao Hu, Yangqiu L. Downregulation of BCL11A by siRNA induces apoptosis in B lymphoma cell lines. Biomedical reports. vol 1. issue 1. 2021-10-21. PMID:24648892. |
in this study, we investigated whether the downregulation of bcl11a mrna by small interference rna (sirna) was capable of inducing apoptosis, and tested the effect of bcl11a sirna combined with bcl2 sirna in b lymphoma cell lines (sudhl6, eb1). |
2021-10-21 |
2023-08-12 |
Not clear |
| Yangjun Gao, Hong Wu, Dongmei He, Xiaomao Hu, Yangqiu L. Downregulation of BCL11A by siRNA induces apoptosis in B lymphoma cell lines. Biomedical reports. vol 1. issue 1. 2021-10-21. PMID:24648892. |
moreover, bcl11a sirna combined with bcl2 sirna increased apoptosis in sudhl6, eb1 cells. |
2021-10-21 |
2023-08-12 |
Not clear |
| Meng Song, Xueping Ou, Cuicui Xiao, Zhongming Xiao, Fang Wei, Yan Hon. Hedgehog signaling inhibitor cyclopamine induces apoptosis by decreasing Gli2 and Bcl2 expression in human salivary pleomorphic adenoma cells. Biomedical reports. vol 1. issue 2. 2021-10-21. PMID:24648943. |
hedgehog signaling inhibitor cyclopamine induces apoptosis by decreasing gli2 and bcl2 expression in human salivary pleomorphic adenoma cells. |
2021-10-21 |
2023-08-12 |
human |