| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nehal M El-Deeb, Mai A Abo-Eleneen, Omyma A Awad, Atef M Abo-Shad. Arthrospira platensis-Mediated Green Biosynthesis of Silver Nano-particles as Breast Cancer Controlling Agent: In Vitro and In Vivo Safety Approaches. Applied biochemistry and biotechnology. 2022-01-20. PMID:35048281. |
in addition, a-bio-agnps induced breast cancer cellular apoptosis by downregulating the expression of survivin, mmp7, tgf, and bcl2 genes. |
2022-01-20 |
2023-08-13 |
mouse |
| Zirui Lü, Xiaona Li, Kebin Li, Paola Ripani, Xiaomeng Shi, Fengrong Xu, Mopei Wang, Liangren Zhang, Thomas Brunner, Ping Xu, Yan Ni. Nitazoxanide and related thiazolides induce cell death in cancer cells by targeting the 20S proteasome with novel binding modes. Biochemical pharmacology. 2022-01-15. PMID:35032461. |
many of these aberrant proteins are regulators of cell cycle progression and apoptosis, such as the cyclins, bcl2 family members and nuclear factor of κb (nf-κb). |
2022-01-15 |
2023-08-13 |
Not clear |
| Yige Yu, Xiu Xin, Feifei Ma, Xiaoheng Li, Yiyan Wang, Qiqi Zhu, Haiqiong Chen, Huitao Li, Ren-Shan G. Bisphenol AF blocks Leydig cell regeneration from stem cells in male rats. Environmental pollution (Barking, Essex : 1987). 2022-01-13. PMID:35026324. |
it induced apoptosis and autophagy by increasing the levels of bax, lc3b, and beclin1 and lowering the levels of bcl2 and p62 at 100 and 200 mg/kg. |
2022-01-13 |
2023-08-13 |
rat |
| Zhen Wang, Xiaoyan Du, Daoyang Yu, Yang Yang, Gaoen Ma, Xueli Jia, Lulu Chen. Sufentanil alleviates cerebral ischemia-reperfusion injury by inhibiting inflammation and protecting the blood-brain barrier in rats. European journal of histochemistry : EJH. vol 66. issue 1. 2022-01-12. PMID:35016494. |
finally, we clarified the apoptosis of brain tissue through the tunel staining and the detection of caspase3, bcl2 and bax. |
2022-01-12 |
2023-08-13 |
rat |
| Zhen Wang, Xiaoyan Du, Daoyang Yu, Yang Yang, Gaoen Ma, Xueli Jia, Lulu Chen. Sufentanil alleviates cerebral ischemia-reperfusion injury by inhibiting inflammation and protecting the blood-brain barrier in rats. European journal of histochemistry : EJH. vol 66. issue 1. 2022-01-12. PMID:35016494. |
suf also inhibited caspase3 and bax rats and promoted bcl2 in mcao rats, thus inhibiting cell apoptosis. |
2022-01-12 |
2023-08-13 |
rat |
| Juan-Juan Li, Mei-Ling Liu, Jia-Ni Lv, Rui-Lin Chen, Ke Ding, Jia-Qi H. Polysaccharides from Platycodonis Radix ameliorated respiratory syncytial virus-induced epithelial cell apoptosis and inflammation through activation of miR-181a-mediated Hippo and SIRT1 pathways. International immunopharmacology. vol 104. 2022-01-09. PMID:34999393. |
mechanistically, prp had the similar effects as mir-181a-5p antagomir on rsv-induced apoptosis and inflammation in hep-2 cells via upregulating bcl2, mll3 and sirt1, which could be reversed by mir-181a-5p mimic. |
2022-01-09 |
2023-08-13 |
mouse |
| Yasmine M Abdel Aziz, Gehad Lotfy, Mohamed M Said, El Sayed H El Ashry, El Sayed H El Tamany, Saied M Soliman, Marwa M Abu-Serie, Mohamed Teleb, Sammer Yousuf, Alexander Dömling, Luis R Domingo, Assem Baraka. Design, Synthesis, Chemical and Biochemical Insights Into Novel Hybrid Spirooxindole-Based p53-MDM2 Inhibitors With Potential Bcl2 Signaling Attenuation. Frontiers in chemistry. vol 9. 2021-12-31. PMID:34970530. |
combination studies disclosed that concomitant administration of bcl2 inhibitors can sensitize the tumor cells and induce apoptosis. |
2021-12-31 |
2023-08-13 |
Not clear |
| Ghasem Majdi Yazdi, Gholamhasan Vaezi, Vida Hojati, Mohammad Mohammad-Zade. The Effect of 6-gingerol on Growth Factors and Apoptosis Indices in Rats Exposed to Gold Nanoparticles. Basic and clinical neuroscience. vol 12. issue 3. 2021-12-17. PMID:34917289. |
given the antioxidant properties of gingerol (ging), this study aimed to determine the protective effect of 6-gingerol on hippocampal levels of brain-derived neurotrophic factor (bdnf), nerve growth factor (ngf), dna oxidative damage, and the amount of bax and bcl2 apoptosis indices of rats exposed to aunps. |
2021-12-17 |
2023-08-13 |
rat |
| Jitrada Phetfong, Tulyapruek Tawonsawatruk, Witchayapon Kamprom, Pawared Ontong, Dalina Tanyong, Suparerk Borwornpinyo, Aungkura Supokawe. Bone marrow mesenchymal stem cell-derived extracellular vesicles affect proliferation and apoptosis of leukemia cells in vitro. FEBS open bio. 2021-12-15. PMID:34907674. |
msc-evs increased the expression of bid and bax and decreased expression of bcl2, indicating the induction of intrinsic apoptosis in nb4. |
2021-12-15 |
2023-08-13 |
Not clear |
| Gerlinde Karbon, Manuel D Haschka, Hubert Hackl, Claudia Soratroi, Lourdes Rocamora-Reverte, Walther Parson, Heidelinde Fiegl, Andreas Villunge. The BH3-only protein NOXA serves as an independent predictor of breast cancer patient survival and defines susceptibility to microtubule targeting agents. Cell death & disease. vol 12. issue 12. 2021-12-14. PMID:34903710. |
sensitivity to mtas is defined by a subset of pro- and anti-apoptotic bcl2 family proteins controlling mitochondrial apoptosis. |
2021-12-14 |
2023-08-13 |
Not clear |
| Souvik Roy, Anil Kumar Mondru, Tania Chakraborty, Abhijit Das, Sandipan Dasgupt. Apple polyphenol phloretin complexed with ruthenium is capable of reprogramming the breast cancer microenvironment through modulation of PI3K/Akt/mTOR/VEGF pathways. Toxicology and applied pharmacology. 2021-12-13. PMID:34896434. |
ruthenium-phloretin complex could modulate p53 intervene apoptosis in the breast carcinoma, initiated by the trail of intrinsic apoptosis facilitated through bcl2 and bax and at the same time down regulating the pi3k/akt/mtor pathway coupled with mmp9 regulated tumor invasive pathways. |
2021-12-13 |
2023-08-13 |
human |
| Ying He, Wei Wang, Xiaoxiao Xu, Beining Yang, Xijie Yu, Yanru Wu, Jiawei Wan. Mettl3 inhibits the apoptosis and autophagy of chondrocytes in inflammation through mediating Bcl2 stability via Ythdf1-mediated m Bone. vol 154. 2021-12-11. PMID:34530171. |
mettl3 inhibits the apoptosis and autophagy of chondrocytes in inflammation through mediating bcl2 stability via ythdf1-mediated m n |
2021-12-11 |
2023-08-13 |
Not clear |
| Yi Liu, Jing Guo, June Zhang, Yunyun Deng, Guanghua Xiong, Jianpin Fu, Lili Wei, Huiqiang L. Chlorogenic acid alleviates thioacetamide-induced toxicity and promotes liver development in zebrafish (Danio rerio) through the Wnt signaling pathway. Aquatic toxicology (Amsterdam, Netherlands). vol 242. 2021-12-10. PMID:34856462. |
the results of western blotting analysis showed that cga inhibited cell apoptosis by increasing the levels of bcl2 apoptosis regulator and decreasing the levels of bcl2 associated x (bax), apoptosis regulator and tumor protein p53. |
2021-12-10 |
2023-08-13 |
cat |
| Laura E Sperl, Florian Rührnößl, Anita Schiller, Martin Haslbeck, Franz Hag. High-resolution analysis of the conformational transition of pro-apoptotic Bak at the lipid membrane. The EMBO journal. vol 40. issue 20. 2021-12-08. PMID:34523144. |
permeabilization of the outer mitochondrial membrane by pore-forming bcl2 proteins is a crucial step for the induction of apoptosis. |
2021-12-08 |
2023-08-13 |
Not clear |
| Darko Maric, Aleksandra Paterek, Marion Delaunay, Irene Pérez López, Miroslav Arambasic, Dario Divian. A-Kinase Anchoring Protein 2 Promotes Protection against Myocardial Infarction. Cells. vol 10. issue 11. 2021-12-08. PMID:34831084. |
this results in the upregulation of er-dependent genes involved in protection against apoptosis and angiogenesis, including bcl2 and the vascular endothelial growth factor a (vegfa). |
2021-12-08 |
2023-08-13 |
mouse |
| Darko Maric, Aleksandra Paterek, Marion Delaunay, Irene Pérez López, Miroslav Arambasic, Dario Divian. A-Kinase Anchoring Protein 2 Promotes Protection against Myocardial Infarction. Cells. vol 10. issue 11. 2021-12-08. PMID:34831084. |
in line with these findings, cardiomyocyte-specific akap2 ko reduces bcl2 and vegfa expression, increases myocardial apoptosis and impairs the formation of new blood vessels in infarcted hearts. |
2021-12-08 |
2023-08-13 |
mouse |
| Hang Hu, Xinshan Zhao, Yalei Cui, Shengkang Li, Yi Gon. SpTIA-1 suppresses WSSV infection by promoting apoptosis in mud crab (Scylla paramamosain). Molecular immunology. vol 140. 2021-12-07. PMID:34715578. |
tia-1 (t cell restricted intracellular antigen-1) is a kind of rna-binding protein which serves as the downstream of ced-9 (a bcl2 homolog) and induces apoptosis under stress conditions. |
2021-12-07 |
2023-08-13 |
Not clear |
| Wulan Koagouw, Richard J Hazell, Corina Cioca. Induction of apoptosis in the gonads of Mytilus edulis by metformin and increased temperature, via regulation of HSP70, CASP8, BCL2 and FAS. Marine pollution bulletin. vol 173. issue Pt A. 2021-12-06. PMID:34649205. |
induction of apoptosis in the gonads of mytilus edulis by metformin and increased temperature, via regulation of hsp70, casp8, bcl2 and fas. |
2021-12-06 |
2023-08-13 |
Not clear |
| Wulan Koagouw, Richard J Hazell, Corina Cioca. Induction of apoptosis in the gonads of Mytilus edulis by metformin and increased temperature, via regulation of HSP70, CASP8, BCL2 and FAS. Marine pollution bulletin. vol 173. issue Pt A. 2021-12-06. PMID:34649205. |
conversely, metformin may induce apoptosis by suppressing the anti-apoptotic gene bcl2, thus promoting the process. |
2021-12-06 |
2023-08-13 |
Not clear |
| A Wnuk, K Przepiórska, B A Pietrzak, M Kajt. Posttreatment Strategy Against Hypoxia and Ischemia Based on Selective Targeting of Nonnuclear Estrogen Receptors with PaPE-1. Neurotoxicity research. vol 39. issue 6. 2021-12-04. PMID:34797527. |
the mechanisms of the neuroprotective action of pape-1 also involved apoptosis inhibition demonstrated by normalization of both mitochondrial membrane potential and expression levels of apoptosis-related genes and proteins such as fas, fasl, bcl2, fas, fasl, bcl2, bax, and gsk3β. |
2021-12-04 |
2023-08-13 |
mouse |