| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chibuisi G Alimba, Ashwinkumar P Rudrashetti, Saravanadevi Sivanesan, Kannan Krishnamurth. Landfill soil leachates from Nigeria and India induced DNA damage and alterations in genes associated with apoptosis in Jurkat cell. Environmental science and pollution research international. 2021-08-21. PMID:34417692. |
there was significant increase in fold change of the up-regulated genes; apoptosis inducing factor mitochondrion-associated 2 (aifm2), fas-associated death domain (fadd), caspase-2, caspase-6, bh3 interacting domain death agonist (bid), tumor suppressor (p53), and bcl2 associated agonist of cell death (bad) and down-regulation of apoptosis inhibitor 5 (api5). |
2021-08-21 |
2023-08-13 |
human |
| Lalrawngbawli Annie, Guruswami Gurusubramanian, Vikas Kumar Ro. Visfatin protein may be responsible for suppression of proliferation and apoptosis in the infantile mice ovary. Cytokine. vol 140. 2021-08-20. PMID:33476980. |
these findings suggest that visfatin in the infantile ovary may suppress the proliferation and apoptosis by up-regulating bcl2 expression. |
2021-08-20 |
2023-08-13 |
mouse |
| Lalrawngbawli Annie, Guruswami Gurusubramanian, Vikas Kumar Ro. Visfatin protein may be responsible for suppression of proliferation and apoptosis in the infantile mice ovary. Cytokine. vol 140. 2021-08-20. PMID:33476980. |
in conclusion, visfatin inhibits the proliferation and apoptosis without modulating the ovarian steroid biosynthesis and visfatin mediated bcl2 expression could also be mechanism to preserve the good quality follicle in early postnatal period. |
2021-08-20 |
2023-08-13 |
mouse |
| Yong Zuo, Jinhong Xie, Xincheng Li, Yan Li, Anand Thirupathi, Jianhua Zhang, Peng Yu, Guofen Gao, Yanzhong Chang, Zhenhua Sh. Ferritinophagy-Mediated Ferroptosis Involved in Paraquat-Induced Neurotoxicity of Dopaminergic Neurons: Implication for Neurotoxicity in PD. Oxidative medicine and cellular longevity. vol 2021. 2021-08-17. PMID:34394837. |
meanwhile, bcl2, bax, and p-38 were involved in apoptosis induced by pq. |
2021-08-17 |
2023-08-13 |
mouse |
| Haiying Fu, Junjie Zhang, Mayu Huan. Topiroxostat ameliorates oxidative stress and inflammation in sepsis-induced lung injury. Zeitschrift fur Naturforschung. C, Journal of biosciences. vol 75. issue 11-12. 2021-08-13. PMID:32589612. |
the cell apoptosis in lung was detected by tunnel staining and western blot analysis of apoptosis-related proteins including pro-apoptosis proteins, bax, cleaved caspase9, cleaved caspase3 and anti-apoptosis protein bcl2. |
2021-08-13 |
2023-08-13 |
rat |
| Dejun Xu, Lingbin Liu, Yongju Zhao, Li Yang, Jianyong Cheng, Rongmao Hua, Zelin Zhang, Qingwang L. Melatonin protects mouse testes from palmitic acid-induced lipotoxicity by attenuating oxidative stress and DNA damage in a SIRT1-dependent manner. Journal of pineal research. vol 69. issue 4. 2021-08-13. PMID:32761924. |
moreover, melatonin therapy suppressed pa-induced apoptosis by modulating apoptosis-associated proteins such as bcl2, bax, c-caspase3, c-caspase12, and chop in type b spermatogonial stem cells. |
2021-08-13 |
2023-08-13 |
mouse |
| Xiaoli Gao, Xiaoyu Huang, Qiaoli Yang, Shengwei Zhang, Zunqiang Yan, Ruirui Luo, Pengfei Wang, Wei Wang, Kaihui Xie, Shuangbao Gu. MicroRNA-21-5p targets PDCD4 to modulate apoptosis and inflammatory response to Clostridium perfringens beta2 toxin infection in IPEC-J2 cells. Developmental and comparative immunology. vol 114. 2021-08-13. PMID:32888967. |
noteworthily, transfection of cpb2-treated ipec-j2 cells with mir-21-5p mimic increased cell viability and bcl2 expression, as well as reduced cytotoxicity, apoptosis rates and bax level. |
2021-08-13 |
2023-08-13 |
Not clear |
| Yu-Jun Dai, Si-Yuan He, Fang Hu, Xue-Ping Li, Jian-Ming Zhang, Si-Liang Chen, Wei-Na Zhang, Hai-Min Sun, Da-Wei Wan. Bone marrow infiltrated natural killer cells predicted the anti-leukemia activity of MCL1 or BCL2 inhibitors in acute myeloid leukemia. Molecular cancer. vol 20. issue 1. 2021-08-12. PMID:33402171. |
furthermore, mcl1 inhibitor but not bcl2 inhibitor combined with nk cell-based immunotherapy could effectively improve the therapeutic efficiency via inhibiting proliferation and inducing apoptosis of aml primary cells as well as cell lines in vitro. |
2021-08-12 |
2023-08-13 |
Not clear |
| Allal Ouhtit, Ishita Gupta, Rajiv L Gaur, Augusta Fernando, Amira O Abd El-Azim, Ali Ei. Deregulation of cell growth and apoptosis in UV-induced melanomagenesis. Frontiers in bioscience (Elite edition). vol 12. 2021-08-09. PMID:32114459. |
more interestingly, p16 mutant cells increased their resistance to apoptosis at high uvb-dose, associated with decreased bax and increased bcl2 expression. |
2021-08-09 |
2023-08-13 |
Not clear |
| Jie Zeng, Yu Zhao, Kexun Li, Daoling Long, Wei Li, Liang Lian. A coordinated ruthenium-rifampicin complex reprogramming the colon carcinoma micro-environment mediated by modulation of p53/AkT/mTOR/VEGF pathway. Toxicology and applied pharmacology. vol 426. 2021-08-06. PMID:34126112. |
along with that, p53 could be modulated by the ruthenium-rifampicin complex to interfere with apoptosis in colon carcinoma, initiated by the intrinsic apoptotic trail facilitated through bcl2 and bax, thus controlling the akt/mtor/vegf pathway coupled through the wnt/β-catenin trail. |
2021-08-06 |
2023-08-13 |
human |
| Bin Shen, Lan Wang, Yuejun Xu, Hongwei Wang, Shiyi H. Long non-coding RNA ZFAS1 exerts a protective role to alleviate oxygen and glucose deprivation-mediated injury in ischemic stroke cell model through targeting miR-186-5p/MCL1 axis. Cytotechnology. vol 73. issue 4. 2021-08-06. PMID:34349350. |
the interaction between microrna-186-5p (mir-186-5p) and zfas1 or mcl1 apoptosis regulator, bcl2 family member (mcl1) was confirmed by dual-luciferase reporter assay, rna-pull down assay and rna immunoprecipitation (rip) assay. |
2021-08-06 |
2023-08-13 |
Not clear |
| J Rzemieniec, E Bratek, A Wnuk, K Przepiórska, E Salińska, M Kajt. Neuroprotective effect of 3,3'-Diindolylmethane against perinatal asphyxia involves inhibition of the AhR and NMDA signaling and hypermethylation of specific genes. Apoptosis : an international journal on programmed cell death. vol 25. issue 9-10. 2021-07-30. PMID:32816128. |
in addition, dim inhibited apoptosis and oxidative stress accompanying perinatal asphyxia through: downregulation of fas, casp-3, capn1, gpx3 and sod-1, attenuation of caspase-9 activity, and upregulation of anti-apoptotic bcl2 mrna. |
2021-07-30 |
2023-08-13 |
human |
| Rehna Krishnan, Mariappan Murugiah, Naga Padma Lakshmi, Sundarasamy Mahalinga. Guanine nucleotide binding protein like-1 (GNL1) promotes cancer cell proliferation and survival through AKT/p21 Molecular biology of the cell. vol 31. issue 26. 2021-07-29. PMID:33147101. |
here, we report for the first time that gnl1 inhibits apoptosis by modulating the expression of bcl2 family of proteins and the cleavage of caspases 7 and 8. |
2021-07-29 |
2023-08-13 |
human |
| Ling Jin, Liang Ren, Jing Lu, Xue Wen, Siying Zhuang, Ting Geng, Yuanzhen Zhan. CXCL12 and its receptors regulate granulosa cell apoptosis in PCOS rats and human KGN tumor cells. Reproduction (Cambridge, England). vol 161. issue 2. 2021-07-29. PMID:33258800. |
in pcos rats, the ovarian expression of cxcl12, cxcr4, and cxcr7 was reduced, and the apoptosis rate of granulosa cells was increased, accompanied by decreased expression of bcl2 and increased expression of bax and cleaved caspase3 (casp3). |
2021-07-29 |
2023-08-13 |
human |
| Ling Jin, Liang Ren, Jing Lu, Xue Wen, Siying Zhuang, Ting Geng, Yuanzhen Zhan. CXCL12 and its receptors regulate granulosa cell apoptosis in PCOS rats and human KGN tumor cells. Reproduction (Cambridge, England). vol 161. issue 2. 2021-07-29. PMID:33258800. |
we further showed that recombinant human cxcl12 treatment upregulated bcl2, downregulated bax, and cleaved casp3 in kgn cells to inhibit their apoptosis in a concentration-dependent manner; moreover, the effect of cxcl12 was weakened by cxcr4 antagonist amd3100 and anti-cxcr7 neutralizing antibody. |
2021-07-29 |
2023-08-13 |
human |
| Ling Jin, Liang Ren, Jing Lu, Xue Wen, Siying Zhuang, Ting Geng, Yuanzhen Zhan. CXCL12 and its receptors regulate granulosa cell apoptosis in PCOS rats and human KGN tumor cells. Reproduction (Cambridge, England). vol 161. issue 2. 2021-07-29. PMID:33258800. |
further, in human kgn cells, cxcl12 regulated the expression of bax, bcl2, and cleaved casp3 to inhibit apoptosis through cxcr4- and cxcr7-mediated signal transmission. |
2021-07-29 |
2023-08-13 |
human |
| Leila Soufi, Alireza Farasat, Hossein Ahmadpour-Yazdi, Leila Zolghadr, Nematollah Gheib. The effects of the esterified Quercetin with omega3 and omega6 fatty acids on viability, nanomechanical properties, and BAX/BCL-2 gene expression in MCF-7 cells. Molecular biology reports. vol 48. issue 6. 2021-07-29. PMID:34254227. |
quercetin is one of the major flavonoids and it appears to have cytotoxic effects on various cancer cells through regulating the apoptosis pathway genes such as bax and bcl2. |
2021-07-29 |
2023-08-13 |
Not clear |
| Shuxin Liang, Fengyu Wang, Changlei Bao, Jing Han, Ying Guo, Fayang Liu, Yong Zhan. BAG2 ameliorates endoplasmic reticulum stress-induced cell apoptosis in Autophagy. vol 16. issue 8. 2021-07-27. PMID:31711362. |
bag2 ameliorates endoplasmic reticulum stress-induced cell apoptosis in bag2 (bcl2 associated athanogene 2) is associated with cell fate determination in response to various pathological conditions. |
2021-07-27 |
2023-08-13 |
Not clear |
| Abdolamir Ghadaksaz, Abbas Ali Imani Fooladi, Hamideh Mahmoodzadeh Hosseini, Taher Nejad Satari, Mohsen Ami. ARA-linker-TGFαL3: a novel chimera protein to target breast cancer cells. Medical oncology (Northwood, London, England). vol 38. issue 8. 2021-07-27. PMID:34273028. |
moreover, rt-pcr was conducted to study the expression of apoptosis (bax, bcl2, and casp3), angiogenesis (vegfr2), and metastasis (mmp2 and mmp9) genes. |
2021-07-27 |
2023-08-13 |
Not clear |
| Bo Wang, Haijia Xu, Jing Kong, Deshan Liu, Wei-Dong Qin, Wenwu Ba. Krüppel-like factor 15 reduces ischemia-induced apoptosis involving regulation of p38/MAPK signaling. Human gene therapy. 2021-07-27. PMID:34314239. |
meanwhile, klf15 overexpression dramatically reduced the myocardial apoptosis, regulated apoptosis-related genes such as bcl2 and bax, diminished the activities of caspase-9/3 and inactivated p38/mapk signaling in the border zone. |
2021-07-27 |
2023-08-13 |
mouse |