| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Federico Lucantoni, Manuela Salvucci, Heiko Düssmann, Andreas U Lindner, Diether Lambrechts, Jochen H M Preh. BCL(X)L and BCL2 increase the metabolic fitness of breast cancer cells: a single-cell imaging study. Cell death and differentiation. vol 28. issue 5. 2021-11-17. PMID:33328572. |
the bcl2 family of proteins regulate apoptosis by controlling mitochondrial outer membrane permeability. |
2021-11-17 |
2023-08-13 |
Not clear |
| Michał M Hryciuk, Katarina Jewgenow, Beate C Brau. Cloprostenol, a synthetic analog of prostaglandin F2α induces functional regression in cultured luteal cells of felids†. Biology of reproduction. vol 105. issue 1. 2021-11-17. PMID:33864060. |
gene-expression analysis by real-time pcr revealed that treatment with cloprostenol did not have an influence on expression of selected genes coding for enzymes of steroidogenesis (star, hsd3b, cyp11a1) or prostaglandin synthesis (ptgs2, pges), nor did it effect hormone receptors (ar, esr1, pgr, ptger2), an anti-oxidative enzyme (sod1) or factors of cell apoptosis (fas, casp3, tnfrsf1b, bcl2) over the studied period. |
2021-11-17 |
2023-08-13 |
cat |
| Shuyu Mei, Shuang Ge, Jun Wang, Hailing Li, Xiaotong Jing, Ke Liang, Xiaoying Zhang, Chaoshuai Xue, Cuijuan Zhang, Tingguo Zhan. PRMT5 promotes progression of endometrioid adenocarcinoma via ERα and cell cycle signaling pathways. The journal of pathology. Clinical research. vol 7. issue 2. 2021-11-15. PMID:33416213. |
knockdown of prmt5 significantly inhibited the growth and migration ability of eac cells and promoted their apoptosis by regulating cyclin d1, c-myc, p53, and bcl2 proteins. |
2021-11-15 |
2023-08-13 |
Not clear |
| Yeon Bi Han, Jeong Mi Yang, Hyun Jung Kwon, Jeong-Ok Lee, Jong Seok Lee, Jin Ho Pai. Clinicopathologic and Prognostic Significance of Bruton's Tyrosine Kinase Expression in Diffuse Large B-Cell Lymphoma. Anticancer research. vol 41. issue 11. 2021-11-15. PMID:34732441. |
we investigated the clinicopathological significance of btk positivity in dlbcl according to known molecules related to resistance to btk inhibitors [bcl2 apoptosis regulator (bcl2)/myc proto-oncogene, bhlh transcription factor (myc)]. |
2021-11-15 |
2023-08-13 |
Not clear |
| Azza Sayed Awad, Hemat A Elariny, Amany Said Salla. Colchicine attenuates renal ischemia-reperfusion-induced liver damage: implication of TLR4/NF-κB, TGF-β, and Canadian journal of physiology and pharmacology. 2021-11-11. PMID:34411492. |
treatment with colchicine significantly reduced hepatic toll-like receptor 4 (tlr4), nuclear factor kappa b (nf-κb) transcription factor, myeloid differentiation factor 88 (myd88), and tumor necrosis factor-alpha (tnf-α) contents; downregulated bcl2 associated x apoptosis regulator ( |
2021-11-11 |
2023-08-13 |
rat |
| Debora Traversa, Giorgia Simonetti, Doron Tolomeo, Grazia Visci, Gemma Macchia, Martina Ghetti, Giovanni Martinelli, Lasse S Kristensen, Clelia Tiziana Storlazz. Unravelling similarities and differences in the role of circular and linear PVT1 in cancer and human disease. British journal of cancer. 2021-11-10. PMID:34754096. |
the stimulation of cell proliferation, invasion and drug resistance, cell metabolism regulation, and apoptosis inhibition is controlled through multiple targets, including myc, p21, stat3, vimentin, cadherins, the pi3k/akt, hk2, bcl2, and casp3. |
2021-11-10 |
2023-08-13 |
human |
| G F Bomfim, G K F Merighe, S A de Oliveira, J A Negra. Acute and chronic effects of cortisol on milk yield, the expression of key receptors, and apoptosis of mammary epithelial cells in Saanen goats. Journal of dairy science. 2021-11-10. PMID:34756435. |
the objective of this study was to investigate the relationship between cort, insulin, prolactin, growth hormone, and insulin-like growth factor-1 in milk as well as the effect of cort on the expression of receptors of insulin (insr), prolactin (prlr), growth hormone (ghr); we also studied the insulin-like growth factor-1 (igf1r), glucocorticoid (nr3c1), mineralocorticoid (nr3c2), b-cell lymphoma 2 (bcl2), bcl-2-like protein x (bax) genes, and the apoptosis rate of mammary epithelial cells of lactating saanen goats in vivo and in vitro. |
2021-11-10 |
2023-08-13 |
Not clear |
| Wan-Xin Peng, Pratirodh Koirala, Huaixiang Zhou, Jiahong Jiang, Ziqiang Zhang, Liu Yang, Yin-Yuan M. Lnc-DC promotes estrogen independent growth and tamoxifen resistance in breast cancer. Cell death & disease. vol 12. issue 11. 2021-11-09. PMID:34697301. |
further analysis suggests that lnc-dc is able to reduce tamoxifen-induced apoptosis by upregulation of anti-apoptotic genes such as bcl2 and bcl-xl. |
2021-11-09 |
2023-08-13 |
Not clear |
| Jiayin Deng, Lucía G Gutiérrez, Gautier Stoll, Omar Motiño, Isabelle Martins, Lucía Núñez, José Manuel Bravo-San Pedro, Juliette Humeau, Chloé Bordenave, Juncheng Pan, Hélène Fohrer-Ting, Sylvie Souquere, Gerard Pierron, Claudio Hetz, Carlos Villalobos, Guido Kroemer, Laura Senovill. Paradoxical implication of BAX/BAK in the persistence of tetraploid cells. Cell death & disease. vol 12. issue 11. 2021-11-09. PMID:34725331. |
pro-apoptotic multi-domain proteins of the bcl2 family such as bax and bak are well known for their important role in the induction of mitochondrial outer membrane permeabilization (momp), which is the rate-limiting step of the intrinsic pathway of apoptosis. |
2021-11-09 |
2023-08-13 |
mouse |
| Hui Song Cui, So Young Joo, Yoon Soo Cho, Ji Heon Park, Yu Mi Ro, June-Bum Kim, Cheong Hoon Se. Effect of extracorporeal shock wave therapy on keratinocytes derived from human hypertrophic scars. Scientific reports. vol 11. issue 1. 2021-11-08. PMID:34453089. |
keratinocytes derived from hypertrophic scar tissue were cultured and expression of proliferation markers (keratin 5 and 14), activation markers (keratin 6 and 17), differentiation markers (keratin 1, 10, and involucrin), apoptosis factors (bax, bcl2, and caspase 14), and proliferation/differentiation regulators (p21 and p27) was investigated to compared with that of those in keratinocytes derived from normal skin tissue. |
2021-11-08 |
2023-08-13 |
human |
| Nadia Fattahi, Abbas Bahari, Ali Ramazani, Davoud Koolivan. In vitro immunobiological assays of methotrexate-stearic acid conjugate in human PBMCs. Immunobiology. vol 225. issue 5. 2021-11-04. PMID:32962811. |
the expression of four key genes involved in inflammation and apoptosis including il-8, il-1β, il-10 and bcl2 depicted that the mtx-sa had controversial behavior in different doses on the inflammatory transcription. |
2021-11-04 |
2023-08-13 |
human |
| Shivangi Sharma, Kontham Kulangara Varsha, Ujjayinee Ray, Humaira Siddiqua, Anjana Elizabeth Jose, Sridhar Muninarasimaiah, Sathees C Raghavan, Bibha Choudhar. Acute toxicity analysis of an inhibitor of BCL2, Disarib, in rats. Scientific reports. vol 11. issue 1. 2021-11-04. PMID:33976278. |
bcl2 family proteins are known to play a vital role in the regulation of apoptosis. |
2021-11-04 |
2023-08-13 |
mouse |
| Angel Y F Kam, Sadhna O Piryani, Chang-Lung Lee, David A Rizzieri, Neil L Spector, Stefanie Sarantopoulos, Phuong L Doa. Selective ERBB2 and BCL2 Inhibition Is Synergistic for Mitochondrial-Mediated Apoptosis in MDS and AML Cells. Molecular cancer research : MCR. vol 19. issue 5. 2021-11-02. PMID:33514658. |
selective erbb2 and bcl2 inhibition is synergistic for mitochondrial-mediated apoptosis in mds and aml cells. |
2021-11-02 |
2023-08-13 |
Not clear |
| Sergio Castro-Gonzalez, Sydney Simpson, Yuhang Shi, Yuexuan Chen, Jared Benjamin, Ruth Serra-Moren. HIV Nef-mediated Ubiquitination of BCL2: Implications in Autophagy and Apoptosis. Frontiers in immunology. vol 12. 2021-11-01. PMID:34025682. |
hiv nef-mediated ubiquitination of bcl2: implications in autophagy and apoptosis. |
2021-11-01 |
2023-08-13 |
Not clear |
| Sergio Castro-Gonzalez, Sydney Simpson, Yuhang Shi, Yuexuan Chen, Jared Benjamin, Ruth Serra-Moren. HIV Nef-mediated Ubiquitination of BCL2: Implications in Autophagy and Apoptosis. Frontiers in immunology. vol 12. 2021-11-01. PMID:34025682. |
importantly, both mitochondrial bcl2 and prkn are tightly connected to mitochondrial function and apoptosis. |
2021-11-01 |
2023-08-13 |
Not clear |
| Sergio Castro-Gonzalez, Sydney Simpson, Yuhang Shi, Yuexuan Chen, Jared Benjamin, Ruth Serra-Moren. HIV Nef-mediated Ubiquitination of BCL2: Implications in Autophagy and Apoptosis. Frontiers in immunology. vol 12. 2021-11-01. PMID:34025682. |
hence, by enhancing the prkn-mediated ubiquitination of bcl2 at the mitochondria, hiv might promote apoptosis. |
2021-11-01 |
2023-08-13 |
Not clear |
| S J Tong, X Y Zhang, H F Guo, J Yang, Y P Qi, S L. Study on effects of miR-141-3p in proliferation, migration, invasion and apoptosis of colon cancer cells by inhibiting Bcl2. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico. vol 23. issue 12. 2021-11-01. PMID:34086253. |
study on effects of mir-141-3p in proliferation, migration, invasion and apoptosis of colon cancer cells by inhibiting bcl2. |
2021-11-01 |
2023-08-13 |
Not clear |
| Nada F Abo El-Magd, Hasnaa Ali Ebrahim, Mohamed El-Sherbiny, Nada H Eis. Quinacrine Ameliorates Cisplatin-Induced Renal Toxicity via Modulation of Sirtuin-1 Pathway. International journal of molecular sciences. vol 22. issue 19. 2021-11-01. PMID:34639002. |
moreover, quinacrine significantly blocked cisplatin-induced apoptosis, which was made evident by downregulating renal apoptotic proteins (bax and p53) and upregulating the renal anti-apoptotic protein bcl2, compared with the cisplatin group. |
2021-11-01 |
2023-08-13 |
rat |
| Cheng Wang, Changxi Qi, Mingchao Liu, Lumei Wang, Guodong Cheng, Liping Li, Yuxiao Xing, Xiaona Zhao, Jianzhu Li. Protective effects of agrimonolide on hypoxia-induced H9c2 cell injury by maintaining mitochondrial homeostasis. Journal of cellular biochemistry. 2021-11-01. PMID:34724244. |
am inhibited the rate of apoptosis by regulating the expression of apoptosis-related proteins, reducing the level of cleaved caspase 3 and bax, and increasing the level of bcl2, thereby protecting h9c2 cells from hypoxia-induced apoptosis. |
2021-11-01 |
2023-08-13 |
Not clear |
| Yu Wang, Liming Zhu, Mei Guo, Gang Sun, Kun Zhou, Wenjing Pang, Dachun Cao, Xin Tang, Xiangjun Men. Correction to: Histone methyltransferase WHSC1 inhibits colorectal cancer cell apoptosis via targeting anti-apoptotic BCL2. Cell death discovery. vol 7. issue 1. 2021-10-26. PMID:34675194. |
correction to: histone methyltransferase whsc1 inhibits colorectal cancer cell apoptosis via targeting anti-apoptotic bcl2. |
2021-10-26 |
2023-08-13 |
Not clear |