| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Soghra Mehri, Samira Barangi, Ehsan Zamiri, Gholamreza Karim. The protective effect of melatonin on benzo(a)pyrene-induced brain injury: role of apoptosis and autophagy pathways. Naunyn-Schmiedeberg's archives of pharmacology. vol 393. issue 12. 2021-09-24. PMID:32632567. |
western blot was conducted for the level of lc3 ii/i and beclin1, as autophagy markers, caspase3 and bcl2, as apoptosis proteins, and sirt1 in the brain. |
2021-09-24 |
2023-08-13 |
mouse |
| Manuel D Haschka, Gerlinde Karbon, Claudia Soratroi, Katelyn L O'Neill, Xu Luo, Andreas Villunge. MARCH5-dependent degradation of MCL1/NOXA complexes defines susceptibility to antimitotic drug treatment. Cell death and differentiation. vol 27. issue 8. 2021-09-23. PMID:32015503. |
degradation of the antiapoptotic bcl2 family member mcl-1 is considered to set the time until onset of apoptosis upon mta treatment. |
2021-09-23 |
2023-08-13 |
Not clear |
| Qingqing Li, Yansong Zhang, Yufang Yang, Songqing Huang, Xiaoqin Zou, Congying Wei, Taolin Liang, Xiaobin Zhon. Panax notoginseng saponins reduces the cisplatin-induced acute renal injury by increasing HIF-1α/BNIP3 to inhibit mitochondrial apoptosis pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 142. 2021-09-22. PMID:34385105. |
cell viability, mitochondrial function, cell apoptosis ratio and the expression of apoptosis-associated proteins (cyt c, bcl2, bax, caspases 3) were determined. |
2021-09-22 |
2023-08-13 |
human |
| Xuejiao An, Taotao Li, Nana Chen, Huihui Wang, Xia Wang, Youji M. PGAM1 regulates the glycolytic metabolism of SCs in tibetan sheep and its influence on the development of SCs. Gene. vol 804. 2021-09-22. PMID:34418471. |
the mrna expression of the cell proliferation-related genes pcna and bcl2 was significantly increased (p < 0.05), and the expression of cell apoptosis related genes bax and caspase3 was significantly decreased (p < 0.05). |
2021-09-22 |
2023-08-13 |
Not clear |
| Lisenn Lalier, Vincent Mignard, Marie-Pierre Joalland, Didier Lanoé, Pierre-François Cartron, Stéphen Manon, François M Vallett. TOM20-mediated transfer of Bcl2 from ER to MAM and mitochondria upon induction of apoptosis. Cell death & disease. vol 12. issue 2. 2021-09-21. PMID:33589622. |
tom20-mediated transfer of bcl2 from er to mam and mitochondria upon induction of apoptosis. |
2021-09-21 |
2023-08-13 |
Not clear |
| Lisenn Lalier, Vincent Mignard, Marie-Pierre Joalland, Didier Lanoé, Pierre-François Cartron, Stéphen Manon, François M Vallett. TOM20-mediated transfer of Bcl2 from ER to MAM and mitochondria upon induction of apoptosis. Cell death & disease. vol 12. issue 2. 2021-09-21. PMID:33589622. |
in u251 glioma cells, we found that bcl2 is localized mainly in the er and is translocated to mam and mitochondria upon induction of apoptosis; this mitochondrial transfer was not restricted to the demonstrator cell line, even if cell-specific modulations exist. |
2021-09-21 |
2023-08-13 |
Not clear |
| Lixia Feng, Xu Chen, Shenghua Zhang, Yunxia Chen, Yanling Y. Role of miR-139-5p in ectopic endometrial stromal cells and the underlying molecular mechanism. Experimental and therapeutic medicine. vol 22. issue 5. 2021-09-21. PMID:34539847. |
bbc3 (bcl2 binding component 3) is a known apoptosis inducer and it serves key roles in the regulation of cell behavior. |
2021-09-21 |
2023-08-13 |
Not clear |
| Ling Hu, Xi Pan, Jinyue Hu, Hong Zeng, Xueting Liu, Manli Jiang, Binyuan Jian. Proteasome inhibitors decrease paclitaxel‑induced cell death in nasopharyngeal carcinoma with the accumulation of CDK1/cyclin B1. International journal of molecular medicine. vol 48. issue 4. 2021-09-18. PMID:34435645. |
in addition, proteasome inhibitors combined with paclitaxel led to decreased mcl1 apoptosis regulator, bcl2 family member/caspase‑9/poly (adp‑ribose) polymerase apoptosis signaling triggered by cdk1/cyclin b1. |
2021-09-18 |
2023-08-13 |
Not clear |
| Lin Zhu, Jing Wu, Hong Li. Downregulation of HERC5 E3 ligase attenuates the ubiquitination of CtBP1 to inhibit apoptosis in colorectal cancer cells. Carcinogenesis. vol 42. issue 8. 2021-09-15. PMID:34147029. |
this transcriptional complex binds to the promoters of three proapoptotic genes, bcl2 associated x (bax), bcl2 interacting killer (bik) and p53upregulated modulator of apoptosis (puma), and inhibits their expression, thereby suppressing apoptotic signalling and promoting tumourigenesis. |
2021-09-15 |
2023-08-13 |
Not clear |
| Tanmoy Roychowdhury, Haocheng Lu, Whitney E Hornsby, Bradley Crone, Gao T Wang, Dong-Chuan Guo, Anoop K Sendamarai, Poornima Devineni, Maoxuan Lin, Wei Zhou, Sarah E Graham, Brooke N Wolford, Ida Surakka, Zhenguo Wang, Lin Chang, Jifeng Zhang, Michael Mathis, Chad M Brummett, Tori L Melendez, Michael J Shea, Karen Meekyong Kim, G Michael Deeb, Himanshu J Patel, Jonathan Eliason, Kim A Eagle, Bo Yang, Santhi K Ganesh, Ben Brumpton, Bjørn Olav Åsvold, Anne Heidi Skogholt, Kristian Hveem, Saiju Pyarajan, Derek Klarin, Philip S Tsao, Scott M Damrauer, Suzanne M Leal, Dianna M Milewicz, Y Eugene Chen, Minerva T Garcia-Barrio, Cristen J Wille. Regulatory variants in TCF7L2 are associated with thoracic aortic aneurysm. American journal of human genetics. vol 108. issue 9. 2021-09-15. PMID:34265237. |
in vitro, we show that upregulation of tcf7l2 is associated with bcl2 repression promoting vascular smooth muscle cell apoptosis, a key driver of taa disease. |
2021-09-15 |
2023-08-13 |
Not clear |
| Felipe Castro-Martinez, Aurora Candelario-Martinez, Maria R Encarnacion-Garcia, Zayda Piedra-Quintero, Raul Bonilla-Moreno, Abigail Betanzos, Rocio Perez-Orozco, Maria A Hernandez-Cueto, Jose E Muñoz-Medina, Genaro Patiño-Lopez, Michael Schnoor, Nicolas Villegas-Sepulveda, Porfirio Nav. Rictor/Mammalian Target of Rapamycin Complex 2 Signaling Protects Colonocytes from Apoptosis and Prevents Epithelial Barrier Breakdown. The American journal of pathology. vol 191. issue 9. 2021-09-13. PMID:34139193. |
mechanistically, mtorc2 activates akt, which, in turn, inhibits apoptosis by phosphorylating b-cell lymphoma 2 (bcl2) associated agonist of cell death (bad) and preventing caspase-3 activation. |
2021-09-13 |
2023-08-13 |
Not clear |
| Yuko Nakayama, Kohji Takara, Tetsuya Minegaki, Kazuhiro Yamamoto, Tomohiro Omura, Ikuko Yan. Induction of Cross-resistance to ABCB1 Substrates in Venetoclax-resistant Human Leukemia HL60 Cells. Anticancer research. vol 41. issue 9. 2021-09-13. PMID:34475043. |
resistance to venetoclax, a selective inhibitor of bcl2 apoptosis regulator (bcl2), is regarded as a clinical problem. |
2021-09-13 |
2023-08-13 |
human |
| Yuefan Li, Xiaofei Li, Ling Wang, Na Han, Gang Yi. miR-375-3p contributes to hypoxia-induced apoptosis by targeting forkhead box P1 (FOXP1) and Bcl2 like protein 2 (Bcl2l2) in rat cardiomyocyte h9c2 cells. Biotechnology letters. vol 43. issue 2. 2021-09-10. PMID:33128129. |
mir-375-3p contributes to hypoxia-induced apoptosis by targeting forkhead box p1 (foxp1) and bcl2 like protein 2 (bcl2l2) in rat cardiomyocyte h9c2 cells. |
2021-09-10 |
2023-08-13 |
rat |
| Leonardo Lorente, María M Martín, Agustín F González-Rivero, Antonia Pérez-Cejas, Luis Ramos-Gómez, Juan J Cáceres, Jordi Solé-Violán, Jacobo J Villacampa-Jiménez, Alejandro Jiméne. Serum B cell lymphoma-2 concentrations and mortality of patients with spontaneous intracerebral hemorrhage. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 42. issue 9. 2021-09-06. PMID:33433754. |
there is scarce data on b cell lymphoma 2 (bcl2), a member of the bcl-2 family of antiapoptotic molecules of the intrinsic apoptosis pathway, in patients with spontaneous intracerebral hemorrhage (sih). |
2021-09-06 |
2023-08-13 |
human |
| Yueyang Wang, Xiaojing Li, Yujie Yao, Xia Zhao, Xu Shi, Yan Ca. Selenium Deficiency Induces Apoptosis and Necroptosis Through ROS/MAPK Signal in Human Uterine Smooth Muscle Cells. Biological trace element research. 2021-09-04. PMID:34480665. |
in addition, se deficiency led to increased intracellular ros content, p-p38 and p-jnk gene expression levels (p < 0.05), the mitochondrial apoptosis pathway bax, casp9 and cle-casp3 protein expression levels (p < 0.05), and decreased bcl2 protein expression level (p < 0.05), simultaneously, increased necroptosis marker genes rip1, rip3, and mlkl protein expression levels (p < 0.05) with a dose-dependent pattern. |
2021-09-04 |
2023-08-13 |
human |
| Jingyu Zhang, Yandong Xie, Qingling Fan, Cheng Wan. Effects of karanjin on dimethylhydrazine induced colon carcinoma and aberrant crypt foci are facilitated by alteration of the p53/Bcl2/BAX pathway for apoptosis. Biotechnic & histochemistry : official publication of the Biological Stain Commission. vol 96. issue 3. 2021-09-03. PMID:32580584. |
colon tissues were investigated using tunel analysis of apoptosis; histopathological assessment including number of aberrant crypt foci (acf); immunohistochemical staining for bcl-2-associated x protein (bax), b-cell lymphoma 2 (bcl2), p53 and proliferating cell nuclear antigen (pcna); and antioxidant assay in vivo. |
2021-09-03 |
2023-08-13 |
rat |
| Wulan Koagouw, Nicolas A Stewart, Corina Cioca. Long-term exposure of marine mussels to paracetamol: is time a healer or a killer? Environmental science and pollution research international. vol 28. issue 35. 2021-09-03. PMID:33928507. |
variations in mrna expression of four other genes involved in apoptosis (hsp70, casp8, bcl2, and fas) are also highlighted. |
2021-09-03 |
2023-08-13 |
Not clear |
| Chunqiu Xiong, Bingbing Yan, Suhua Xia, Fei Yu, Jingjing Zhao, Hua Ba. Tilianin inhibits the human ovarian cancer (PA-1) cell proliferation via blocking cell cycle, inducing apoptosis and inhibiting JAK2/STAT3 signaling pathway. Saudi journal of biological sciences. vol 28. issue 9. 2021-09-03. PMID:34466064. |
the tilianin-triggered apoptosis in pa-1 cells was correlated with elevated generation of ros, loss of mitochondrial membrane potential, alterations in pro-apoptotic (upregulated mrna expression of bax) and anti-apoptotic (downregulated mrna expression of bcl2) factors and activation of caspase-8, -9 and -3. |
2021-09-03 |
2023-08-13 |
human |
| Jimmy Lee, Y Lynn Wan. Prognostic and Predictive Molecular Biomarkers in Chronic Lymphocytic Leukemia. The Journal of molecular diagnostics : JMD. vol 22. issue 9. 2021-08-27. PMID:32615167. |
meanwhile, rapid advances in the understanding of the cll oncogenic pathways have led to the development of small-molecule targeting signal transducers, bruton tyrosine kinase and phosphatidylinositol 3-kinase, as well as anti-apoptotic protein bcl2 apoptosis regulator. |
2021-08-27 |
2023-08-13 |
Not clear |
| Tian Tian, Xuanye Cao, Sung-Eun Kim, Ying Linda Lin, John W Steele, Robert M Cabrera, Menuka Karki, Wei Yang, Nicholas J Marini, Ethan N Hoffman, Xiao Han, Cindy Hu, Linlin Wang, Bogdan J Wlodarczyk, Gary M Shaw, Aiguo Ren, Richard H Finnell, Yunping Le. FKBP8 variants are risk factors for spina bifida. Human molecular genetics. vol 29. issue 18. 2021-08-25. PMID:32969478. |
p.glu140* affected fkbp8 localization to the mitochondria and created a truncated form of the fkbp8 protein, thus impairing its interaction with bcl2 and ultimately leading to an increase in cellular apoptosis. |
2021-08-25 |
2023-08-13 |
mouse |