| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Valéria Bumiller-Bini Hoch, Larissa Schneider, Anna Elisabeth Pumpe, Emelie Lüders, Jennifer Elisabeth Hundt, Angelica Beate Winter Bold. Marked to Die-Cell Death Mechanisms for Keratinocyte Acantholysis in Pemphigus Diseases. Life (Basel, Switzerland). vol 12. issue 3. 2022-03-25. PMID:35330080. |
among the molecules, most investigated were pleiotropic molecules such as tnf and casp3, followed by fasl and casp8, and then by fas, bax, bcl2, and tp53, all involved in more than one pathway but interpreted to function only within apoptosis. |
2022-03-25 |
2023-08-13 |
mouse |
| Xun Fang, Bereket Molla Tanga, Seonggyu Bang, Gyeonghwan Seong, Islam M Saadeldin, Ahmad Yar Qamar, Joohyun Shim, Kimyung Choi, Sanghoon Lee, Jongki Ch. Vitamin C enhances porcine cloned embryo development and improves the derivation of embryonic stem-like cells. Reproductive biology. vol 22. issue 2. 2022-03-25. PMID:35334451. |
vitamin c decreased the gene expression of apoptosis (bax) and increased the expression of genes associated with nuclear reprogramming (nanog, pou5f1, sox2, c-myc, klf4, and tead4), antioxidation (sod1), anti-apoptotic (bcl2), and trophectoderm (cdx2). |
2022-03-25 |
2023-08-13 |
Not clear |
| Tingting Zhu, Hongxi Chen, Cuihong He, Xiaojuan Li. Transcription Factor HEY1 Improves Brain Vascular Endothelial Cell Function and Alleviates Ischemic Stroke by Upregulating NOTCH3. Neurochemical research. 2022-03-22. PMID:35316462. |
terminal deoxynucleotidyl transferase dutp nick end labeling and western blotting analysis of cleaved caspase-3 and b-cell lymphoma-2 (bcl2) were used to evaluate apoptosis. |
2022-03-22 |
2023-08-13 |
rat |
| Vanlal Rempuia, Borgohain Anima, Malsawmhriatzuala Jeremy, Guruswami Gurusubramanian, Pranay P Pankaj, Rajesh K Kharwar, Vikas K Ro. Effects of metformin on the uterus of d-galactose-induced aging mice: Histomorphometric, immunohistochemical localization (B-cell lymphoma 2, Bcl2-associated X protein, and active capase3), and oxidative stress study. Journal of experimental zoology. Part A, Ecological and integrative physiology. 2022-03-14. PMID:35286779. |
moreover, it may be concluded that metformin might ameliorate uterine dysfunctions by reducing oxidative stress, suppressing apoptosis, and increasing the survival/antiapoptotic protein bcl2. |
2022-03-14 |
2023-08-13 |
mouse |
| Xiuheng Xue, Caiyun Fan, Luping Wang, Lei Gao, Kai Fan, Mengling Peng, Fugui Fang, Jianbo Cheng, Juhua Wan. Ascorbic acid regulates mouse spermatogonial stem cell proliferation in a Wnt/β-catenin/ROS signaling dependent manner. Theriogenology. vol 184. 2022-03-13. PMID:35279534. |
finally, the appropriate ros in the 40 μg/ml aa group further adjust the levels of dvl2 and nrx protein in the wnt/β-catenin pathway to maintain the nuclear intensity of β-catenin, in turn, the expression of apoptosis gene bax decreased, while the expression of bcl2, axin2, lgr5, c-myc and cyclin d1 genes increased. |
2022-03-13 |
2023-08-13 |
mouse |
| Esmaeel Babaeenezhad, Omid Dezfoulian, Forouzan Hadipour Moradi, Sobhan Rahimi Monfared, Mohammad Davood Fattahi, Maryam Nasri, Abdolhakim Amini, Hassan Ahmadvan. Exogenous glutathione protects against gentamicin-induced acute kidney injury by inhibiting NF-κB pathway, oxidative stress, and apoptosis and regulating PCNA. Drug and chemical toxicology. 2022-03-10. PMID:35266424. |
interestingly, egsh inhibited intrinsic apoptosis by downregulating bax and caspase-3 and upregulating bcl2 in the kidney of rats with aki. |
2022-03-10 |
2023-08-13 |
rat |
| Federico Costanzo, Marta Martínez Diez, Gema Santamaría Nuñez, Juan Ignacio Díaz-Hernandéz, Carlos Mario Genes Robles, Javier Díez Pérez, Emmanuel Compe, Romeo Ricci, Tsai-Kun Li, Frédéric Coin, Juan Fernando Martínez Leal, Eva Maria Garrido-Martin, Jean Marc Egl. Promoters of ASCL1- and NEUROD1-dependent genes are specific targets of lurbinectedin in SCLC cells. EMBO molecular medicine. 2022-03-09. PMID:35263037. |
this abrogates the expression of ascl1 and neurod1 and of their dependent genes, such as bcl2, insm1, myc, and aurka, which are responsible for relevant sclc tumorigenic properties such as inhibition of apoptosis and cell survival, as well as for a part of its neuroendocrine features. |
2022-03-09 |
2023-08-13 |
Not clear |
| Ghazi Elamin, Aimen Aljoundi, Mahmoud E S Solima. Multi-catalytic Sites Inhibition of Bcl2 Induces Expanding of Hydrophobic Groove: A New Avenue Towards Waldenström Macroglobulinemia Therapy. The protein journal. 2022-03-03. PMID:35237907. |
b-cell lymphoma 2 (bcl2) is a key protein regulator of apoptosis. |
2022-03-03 |
2023-08-13 |
human |
| Helena Hohtari, Matti Kankainen, Shady Adnan-Awad, Bhagwan Yadav, Swapnil Potdar, Aleksandr Ianevski, Olli Dufva, Caroline Heckman, Veronika Sexl, Soili Kytölä, Satu Mustjoki, Kimmo Porkk. Targeting Apoptosis Pathways With BCL2 and MDM2 Inhibitors in Adult B-cell Acute Lymphoblastic Leukemia. HemaSphere. vol 6. issue 3. 2022-03-02. PMID:35233509. |
targeting apoptosis pathways with bcl2 and mdm2 inhibitors in adult b-cell acute lymphoblastic leukemia. |
2022-03-02 |
2023-08-13 |
Not clear |
| Stamatia Laidou, Dionysios Grigoriadis, Sofia Papanikolaou, Spyros Foutadakis, Stavroula Ntoufa, Maria Tsagiopoulou, Giannis Vatsellas, Achilles Anagnostopoulos, Anastasia Kouvatsi, Niki Stavroyianni, Fotis Psomopoulos, Antonios Michael Makris, Marios Agelopoulos, Dimitris Thanos, Anastasia Chatzidimitriou, Nikos Papakonstantinou, Kostas Stamatopoulo. The TΑp63/BCL2 Axis Represents A Novel Mechanism Of Clinical Aggressiveness In Chronic Lymphocytic Leukemia. Blood advances. 2022-03-02. PMID:35235952. |
finally, we found that up-regulated tap63 expression levels render cll cells less responsive to apoptosis induction with the bcl2 inhibitor, venetoclax. |
2022-03-02 |
2023-08-13 |
Not clear |
| Dong Chen, Xin Jian. Exosomes-derived miR-125-5p from cartilage endplate stem cells regulates autophagy and ECM metabolism in nucleus pulposus by targeting SUV38H1. Experimental cell research. 2022-03-01. PMID:35231441. |
n-cesc-exo reduced degenerated nucleus pulposus cells (tbhp-npc) apoptosis, bax, mmp13, and p62 expression, while increased bcl2, acan, lc3-ii/i expression, and the fluorescence intensity of gfp-lc3. |
2022-03-01 |
2023-08-13 |
Not clear |
| Xiaoli Yin, Yinghao Ren, Weitao Luo, Meiqiu Liao, Lin Huang, Xueqi Zhuang, Yuan Liu, Weina Wan. Nemo-like kinase (NLK) gene regulates apoptosis via the p53 signaling pathway in Litopenaeus vannamei under low-temperature stress. Developmental and comparative immunology. 2022-03-01. PMID:35231467. |
meanwhile, the bcl2 apoptosis regulator (bcl-2), mdm2 proto-oncogene (mdm2), and yin yang 1 (yy1) were upregulated. |
2022-03-01 |
2023-08-13 |
Not clear |
| Mohammad Almasri, Marah Amer, Joseph Ghanej, Abdurraouf Mokhtar Mahmoud, Gianluca Gaidano, Riccardo Moi. Druggable Molecular Pathways in Chronic Lymphocytic Leukemia. Life (Basel, Switzerland). vol 12. issue 2. 2022-02-25. PMID:35207569. |
moreover, the restoration of apoptosis by the bcl2 inhibitor venetoclax offers meaningful clinical activity with a fixed-duration scheme. |
2022-02-25 |
2023-08-13 |
Not clear |
| Pradip Kumar Jaiswara, Ajay Kuma. Nimbolide retards T cell lymphoma progression by altering apoptosis, glucose metabolism, pH regulation, and ROS homeostasis. Environmental toxicology. 2022-02-24. PMID:35199915. |
we noticed significantly augmented apoptosis in nimbolide- administered tumor-bearing mice, possibly due to down-regulated expression of bcl2 and up-regulated expression of p53, cleaved caspase-3, cyt c, and ros. |
2022-02-24 |
2023-08-13 |
mouse |
| Fazul Nabi, Weilai Tao, Ruiling Ye, Zhenzhen Li, Qin Lu, Yangfei Shang, Yu Hu, Jiali Fang, Zohaib Ahmed Bhutto, Juan Li. Penthorum Chinense Pursh Extract Alleviates Aflatoxin B1-Induced Liver Injury and Oxidative Stress Through Mitochondrial Pathways in Broilers. Frontiers in veterinary science. vol 9. 2022-02-21. PMID:35187148. |
furthermore, supplementation of pcpe to the afb1 group reversed apoptosis by significantly down-regulating the mrna expression levels of bax, bak, caspase-9, caspase-3, and p53 and up-regulating the expression levels of bcl2 in the liver of broilers. |
2022-02-21 |
2023-08-13 |
Not clear |
| Anas Taha, Stephanie Taha-Mehlitz, Stephanie Petzold, Sergey L Achinovich, Dmitry Zinovkin, Bassey Enodien, Md Zahidul I Pranjol, Eldar A Nadyro. Prognostic Value of Immunohistochemical Markers for Locally Advanced Rectal Cancer. Molecules (Basel, Switzerland). vol 27. issue 3. 2022-02-15. PMID:35163861. |
the aim of this study is to reveal the potential roles of apoptosis markers (bcl2 and p53), proliferation markers (ki-67 and cycld1), and the neuroendocrine marker chromogranin a as markers for the radioresistance of rectal cancer. |
2022-02-15 |
2023-08-13 |
Not clear |
| Maryam Farzaneh Behelgardi, Zahra Gholami Shahvir, S Mohsen Asghar. Apoptosis induction in human lung and colon cancer cells via impeding VEGF signaling pathways. Molecular biology reports. 2022-02-10. PMID:35142981. |
encouragingly, significant downregulation of b-cell lymphoma 2 (bcl2), x-linked inhibitor of apoptosis, procaspase9, and procaspase3, as well as upregulation of pten and p53 tumor suppressors, bcl2 associated x, cytochrome c, cleaved caspase9, and cleaved caspase3 in vgb4-treated a549 and ht29 cells, further confirmed the profound inductive influence of vgb4 on apoptotic pathways. |
2022-02-10 |
2023-08-13 |
human |
| Jian Kang, Yan Gu. Human Umbilical Cord Mesenchymal Stem Cells Derived Exosomes Promote Neurological Function Recovery in a Rat Spinal Cord Injury Model. Neurochemical research. 2022-02-08. PMID:35132478. |
intravenous administration of huc-msc derived exosomes dramatically improved motor function of sprague-dawley rats after sci, with reduced apoptosis demonstrated by increased expression of b-cell lymphoma 2 (bcl2), decreased bcl2 associated x, apoptosis regulator (bax), and reduced cleaved caspase 9. |
2022-02-08 |
2023-08-13 |
human |
| Huixin Gao, Yuxia Lin, Changbai Huang, Xiaobo Li, Michael S Diamond, Chao Liu, Rong Zhang, Ping Zhan. A genome-wide CRISPR screen identifies HuR as a regulator of apoptosis induced by dsRNA and virus. Journal of cell science. 2022-02-03. PMID:35112703. |
moreover, protection from dsrna-induced apoptosis by hur depletion required the presence of bcl2, indicating that the proapoptotic function of hur is executed by suppressing bcl2. |
2022-02-03 |
2023-08-13 |
Not clear |
| Ming Kuang, Hong Zhou, Guiting Zhang, Chao He, Qianqian Wu, Yuye Ya. [Ox-LDL/β2GPI/anti-β2GPI antibody complex promotes apoptosis and inflammatory factors expression in RAW264.7 cells]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 38. issue 1. 2022-01-26. PMID:35078569. |
results ox-ldl/β2gpi/aβ2gpi antibody complex promoted raw264.7 cells' apoptosis, with a decrease in protein bcl2 and an increase in protein cleaved-caspase-3, and enhanced the level of inflammatory factors, while apoptosis and the expression of inflammatory factors were partially reduced when macrophages had been pre-treated with inhibitors. |
2022-01-26 |
2023-08-13 |
Not clear |