| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dongfang Dai, Hongping Zhou, Li Yin, Fei Ye, Xiao Yuan, Tao You, Xiaohui Zhao, Weiguo Long, Deqiang Wang, Xia He, Jifeng Feng, Deyu Che. PELI1 promotes radiotherapy sensitivity by inhibiting noncanonical NF-κB in esophageal squamous cancer. Molecular oncology. 2021-11-24. PMID:34738714. |
as a consequence, peli1 inhibited the noncanonical nf-κb-induced expression of the anti-apoptotic gene bcl2 like 1 (bclxl; also known as bcl2l1), leading to an enhancement of the ir-induced apoptosis signaling pathway and ultimately promoting ir-induced apoptosis in tumor cells. |
2021-11-24 |
2023-08-13 |
human |
| Abdullah Al Emran, Hsin-Yi Tseng, Dilini Gunatilake, Stuart J Cook, Farzana Ahmed, Shudong Wang, Peter Hersey, Stuart J Gallagher, Jessamy C Tiffe. A Combination of Epigenetic BET and CDK9 Inhibitors for Treatment of Human Melanoma. The Journal of investigative dermatology. vol 141. issue 9. 2021-11-23. PMID:33781756. |
cell death was associated with mitochondrial depolarization, caspase-dependent apoptosis with cleavage of parp1, and downregulation of anti-apoptotic proteins bcl2, bclxl, and mcl1. |
2021-11-23 |
2023-08-13 |
mouse |
| Jiajie Feng, Jiachen Zhan, Shuangshuang M. LRG1 promotes hypoxia-induced cardiomyocyte apoptosis and autophagy by regulating hypoxia-inducible factor-1α. Bioengineered. vol 12. issue 1. 2021-11-23. PMID:34643170. |
in this study, western blot was applied to detect the protein expression of bax, bcl2, lc3, p62, lrg1 and hypoxia-inducible factor-1α (hif-1α); cck-8 assay was employed to detect cell viability; annexin v-fitc/pi staining was adopted to evaluate apoptosis, and immunofluorescence assay was applied to detect autophagy. |
2021-11-23 |
2023-08-13 |
Not clear |
| Gehad Lotfy, Yasmine M Abdel Aziz, Mohamed M Said, El Sayed H El Ashry, El Sayed H El Tamany, Marwa M Abu-Serie, Mohamed Teleb, Alexander Dömling, Assem Baraka. Molecular hybridization design and synthesis of novel spirooxindole-based MDM2 inhibitors endowed with BCL2 signaling attenuation; a step towards the next generation p53 activators. Bioorganic chemistry. vol 117. 2021-11-23. PMID:34794098. |
combination studies disclosed that concomitant inhibition of mdm2 and bcl2 functions can sensitize the tumor cells and synergistically induce apoptosis. |
2021-11-23 |
2023-08-13 |
Not clear |
| Gehad Lotfy, Yasmine M Abdel Aziz, Mohamed M Said, El Sayed H El Ashry, El Sayed H El Tamany, Marwa M Abu-Serie, Mohamed Teleb, Alexander Dömling, Assem Baraka. Molecular hybridization design and synthesis of novel spirooxindole-based MDM2 inhibitors endowed with BCL2 signaling attenuation; a step towards the next generation p53 activators. Bioorganic chemistry. vol 117. 2021-11-23. PMID:34794098. |
the nci-selected derivatives were screened for cytotoxic activities against normal fibroblasts, mda-mb 231, hepg-2, and caco-2 cells via mtt assay, subjected to mechanistic apoptosis studies for assessment of p53, bcl2, p21, and caspase 3/7 status, then evaluated for potential mdm2 inhibition utilizing mst assay. |
2021-11-23 |
2023-08-13 |
Not clear |
| Vikas A Gupta, Benjamin G Barwick, Shannon M Matulis, Ryosuke Shirasaki, David L Jaye, Jonathan J Keats, Benjamin Oberlton, Nisha S Joseph, Craig C Hofmeister, Leonard T Heffner, Madhav V Dhodapkar, Ajay K Nooka, Sagar Lonial, Constantine S Mitsiades, Jonathan L Kaufman, Lawrence H Bois. Venetoclax sensitivity in multiple myeloma is associated with B-cell gene expression. Blood. vol 137. issue 26. 2021-11-22. PMID:33649772. |
venetoclax is a highly potent, selective bcl2 inhibitor capable of inducing apoptosis in cells dependent on bcl2 for survival. |
2021-11-22 |
2023-08-13 |
Not clear |
| Gui Yang, Jiang-Qi Liu, Li-Hua Mo, Xiang-Qian Luo, Jianxiang Li, Zhi-Qiang Liu, Da-Bo Liu, Zhi-Gang Liu, Ping-Chang Yang, Jian-Bo Sh. Bcl2 like protine-12 (Bcl2L12) facilitates experimental airway allergic inflammation by inducing autocrine eotaxin in eosinophils. Immunology letters. vol 228. 2021-11-18. PMID:33132183. |
bcl2 like protein-12 (bcl2l12) is an apoptosis inhibitor and an immune regulator. |
2021-11-18 |
2023-08-13 |
Not clear |
| Fu Hua, Chang-Hua Li, Xiao-Gang Chen, Xiao-Ping Li. [Retracted] Daidzein exerts anticancer activity towards SKOV3 human ovarian cancer cells by inducing apoptosis and cell cycle arrest, and inhibiting the Raf/MEK/ERK cascade. International journal of molecular medicine. vol 47. issue 6. 2021-11-18. PMID:33846770. |
furthermore, cellular images featured in fig. 2a and b of the above paper appeared in fig. 2 of the following paper, albeit the data were presented in a different field of view: yu l, zhou g‑q and li d‑c: mir‑136 triggers apoptosis in human gastric cancer cells by targeting aeg‑1 and bcl2. |
2021-11-18 |
2023-08-13 |
human |
| Yajie Lu, Min Zhang, Qinjun Wei, Zhibin Chen, Guangqian Xing, Jun Yao, Xin Ca. Disruption of Gprasp2 down-regulates Hedgehog signaling and leads to apoptosis in auditory cells. Biochemical and biophysical research communications. vol 574. 2021-11-18. PMID:34418635. |
the differential expression of apoptosis molecules (bcl2, bax, caspase-3/cleaved-caspase-3) indicated that gprasp2-ko induced apoptosis in hei-oc1 cells. |
2021-11-18 |
2023-08-13 |
mouse |
| Jorge J Castillo, John N Allan, Tanya Siddiqi, Ranjana H Advani, Kirsten Meid, Carly Leventoff, Timothy P White, Catherine A Flynn, Shayna Sarosiek, Andrew R Branagan, Maria G Demos, Maria L Guerrera, Amanda Kofides, Xia Liu, Manit Munshi, Nicholas Tsakmaklis, Lian Xu, Guang Yang, Christopher J Patterson, Zachary R Hunter, Matthew S Davids, Richard R Furman, Steven P Treo. Venetoclax in Previously Treated Waldenström Macroglobulinemia. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2021-11-18. PMID:34793256. |
venetoclax is a potent bcl2 antagonist and triggers in vitro apoptosis of wm cells. |
2021-11-18 |
2023-08-13 |
Not clear |
| Federico Lucantoni, Manuela Salvucci, Heiko Düssmann, Andreas U Lindner, Diether Lambrechts, Jochen H M Preh. BCL(X)L and BCL2 increase the metabolic fitness of breast cancer cells: a single-cell imaging study. Cell death and differentiation. vol 28. issue 5. 2021-11-17. PMID:33328572. |
the bcl2 family of proteins regulate apoptosis by controlling mitochondrial outer membrane permeability. |
2021-11-17 |
2023-08-13 |
Not clear |
| Michał M Hryciuk, Katarina Jewgenow, Beate C Brau. Cloprostenol, a synthetic analog of prostaglandin F2α induces functional regression in cultured luteal cells of felids†. Biology of reproduction. vol 105. issue 1. 2021-11-17. PMID:33864060. |
gene-expression analysis by real-time pcr revealed that treatment with cloprostenol did not have an influence on expression of selected genes coding for enzymes of steroidogenesis (star, hsd3b, cyp11a1) or prostaglandin synthesis (ptgs2, pges), nor did it effect hormone receptors (ar, esr1, pgr, ptger2), an anti-oxidative enzyme (sod1) or factors of cell apoptosis (fas, casp3, tnfrsf1b, bcl2) over the studied period. |
2021-11-17 |
2023-08-13 |
cat |
| Shuyu Mei, Shuang Ge, Jun Wang, Hailing Li, Xiaotong Jing, Ke Liang, Xiaoying Zhang, Chaoshuai Xue, Cuijuan Zhang, Tingguo Zhan. PRMT5 promotes progression of endometrioid adenocarcinoma via ERα and cell cycle signaling pathways. The journal of pathology. Clinical research. vol 7. issue 2. 2021-11-15. PMID:33416213. |
knockdown of prmt5 significantly inhibited the growth and migration ability of eac cells and promoted their apoptosis by regulating cyclin d1, c-myc, p53, and bcl2 proteins. |
2021-11-15 |
2023-08-13 |
Not clear |
| Yeon Bi Han, Jeong Mi Yang, Hyun Jung Kwon, Jeong-Ok Lee, Jong Seok Lee, Jin Ho Pai. Clinicopathologic and Prognostic Significance of Bruton's Tyrosine Kinase Expression in Diffuse Large B-Cell Lymphoma. Anticancer research. vol 41. issue 11. 2021-11-15. PMID:34732441. |
we investigated the clinicopathological significance of btk positivity in dlbcl according to known molecules related to resistance to btk inhibitors [bcl2 apoptosis regulator (bcl2)/myc proto-oncogene, bhlh transcription factor (myc)]. |
2021-11-15 |
2023-08-13 |
Not clear |
| Azza Sayed Awad, Hemat A Elariny, Amany Said Salla. Colchicine attenuates renal ischemia-reperfusion-induced liver damage: implication of TLR4/NF-κB, TGF-β, and Canadian journal of physiology and pharmacology. 2021-11-11. PMID:34411492. |
treatment with colchicine significantly reduced hepatic toll-like receptor 4 (tlr4), nuclear factor kappa b (nf-κb) transcription factor, myeloid differentiation factor 88 (myd88), and tumor necrosis factor-alpha (tnf-α) contents; downregulated bcl2 associated x apoptosis regulator ( |
2021-11-11 |
2023-08-13 |
rat |
| Debora Traversa, Giorgia Simonetti, Doron Tolomeo, Grazia Visci, Gemma Macchia, Martina Ghetti, Giovanni Martinelli, Lasse S Kristensen, Clelia Tiziana Storlazz. Unravelling similarities and differences in the role of circular and linear PVT1 in cancer and human disease. British journal of cancer. 2021-11-10. PMID:34754096. |
the stimulation of cell proliferation, invasion and drug resistance, cell metabolism regulation, and apoptosis inhibition is controlled through multiple targets, including myc, p21, stat3, vimentin, cadherins, the pi3k/akt, hk2, bcl2, and casp3. |
2021-11-10 |
2023-08-13 |
human |
| G F Bomfim, G K F Merighe, S A de Oliveira, J A Negra. Acute and chronic effects of cortisol on milk yield, the expression of key receptors, and apoptosis of mammary epithelial cells in Saanen goats. Journal of dairy science. 2021-11-10. PMID:34756435. |
the objective of this study was to investigate the relationship between cort, insulin, prolactin, growth hormone, and insulin-like growth factor-1 in milk as well as the effect of cort on the expression of receptors of insulin (insr), prolactin (prlr), growth hormone (ghr); we also studied the insulin-like growth factor-1 (igf1r), glucocorticoid (nr3c1), mineralocorticoid (nr3c2), b-cell lymphoma 2 (bcl2), bcl-2-like protein x (bax) genes, and the apoptosis rate of mammary epithelial cells of lactating saanen goats in vivo and in vitro. |
2021-11-10 |
2023-08-13 |
Not clear |
| Wan-Xin Peng, Pratirodh Koirala, Huaixiang Zhou, Jiahong Jiang, Ziqiang Zhang, Liu Yang, Yin-Yuan M. Lnc-DC promotes estrogen independent growth and tamoxifen resistance in breast cancer. Cell death & disease. vol 12. issue 11. 2021-11-09. PMID:34697301. |
further analysis suggests that lnc-dc is able to reduce tamoxifen-induced apoptosis by upregulation of anti-apoptotic genes such as bcl2 and bcl-xl. |
2021-11-09 |
2023-08-13 |
Not clear |
| Jiayin Deng, Lucía G Gutiérrez, Gautier Stoll, Omar Motiño, Isabelle Martins, Lucía Núñez, José Manuel Bravo-San Pedro, Juliette Humeau, Chloé Bordenave, Juncheng Pan, Hélène Fohrer-Ting, Sylvie Souquere, Gerard Pierron, Claudio Hetz, Carlos Villalobos, Guido Kroemer, Laura Senovill. Paradoxical implication of BAX/BAK in the persistence of tetraploid cells. Cell death & disease. vol 12. issue 11. 2021-11-09. PMID:34725331. |
pro-apoptotic multi-domain proteins of the bcl2 family such as bax and bak are well known for their important role in the induction of mitochondrial outer membrane permeabilization (momp), which is the rate-limiting step of the intrinsic pathway of apoptosis. |
2021-11-09 |
2023-08-13 |
mouse |
| Hui Song Cui, So Young Joo, Yoon Soo Cho, Ji Heon Park, Yu Mi Ro, June-Bum Kim, Cheong Hoon Se. Effect of extracorporeal shock wave therapy on keratinocytes derived from human hypertrophic scars. Scientific reports. vol 11. issue 1. 2021-11-08. PMID:34453089. |
keratinocytes derived from hypertrophic scar tissue were cultured and expression of proliferation markers (keratin 5 and 14), activation markers (keratin 6 and 17), differentiation markers (keratin 1, 10, and involucrin), apoptosis factors (bax, bcl2, and caspase 14), and proliferation/differentiation regulators (p21 and p27) was investigated to compared with that of those in keratinocytes derived from normal skin tissue. |
2021-11-08 |
2023-08-13 |
human |