| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaowei Qin, Wenqing Dang, Xiaofeng Yang, Kai Wang, Ermias Kebreab, Lihua Ly. Neddylation inactivation affects cell cycle and apoptosis in sheep follicular granulosa cells. Journal of cellular physiology. 2022-05-17. PMID:35578798. |
meanwhile, the b-cell lymphoma/leukemia 2 (bcl2) family members bcl-2 and mcl-1 were downregulated, subsequently inducing apoptosis in follicular gcs of sheep. |
2022-05-17 |
2023-08-13 |
Not clear |
| Irene Sánchez-Ajofrín, Patricia Peris-Frau, Olga García-Álvarez, María Del Rocío Fernández-Santos, Vidal Montoro, José Julián Garde, Ana Josefa Sole. Serum supplementation during in vitro fertilization of sheep oocytes influences blastocyst quality through the differential abundance of mRNA transcripts. Reproduction in domestic animals = Zuchthygiene. 2022-05-16. PMID:35575960. |
nonetheless, in vitro-produced blastocysts from the 10% ess treatment showed a higher transcript abundance of mrnas involved in apoptosis (itm2b and bcl2), antioxidant defense (gpx1), and growth-related imprinting (igf2r). |
2022-05-16 |
2023-08-13 |
Not clear |
| Ajay K Yadav, Teja Naveen Sata, Daksh Verma, Amit K Mishra, Amrendra K Sah, Md Musa Hossain, Kishor Pant, Senthil K Venugopa. Free fatty acid-induced miR-181a-5p stimulates apoptosis by targeting XIAP and Bcl2 in hepatic cells. Life sciences. 2022-05-13. PMID:35551953. |
free fatty acid-induced mir-181a-5p stimulates apoptosis by targeting xiap and bcl2 in hepatic cells. |
2022-05-13 |
2023-08-13 |
Not clear |
| Ajay K Yadav, Teja Naveen Sata, Daksh Verma, Amit K Mishra, Amrendra K Sah, Md Musa Hossain, Kishor Pant, Senthil K Venugopa. Free fatty acid-induced miR-181a-5p stimulates apoptosis by targeting XIAP and Bcl2 in hepatic cells. Life sciences. 2022-05-13. PMID:35551953. |
in this study, we showed that free fatty acids stimulate apoptosis by upregulating mir-181a-5p expression, which in turn targets xiap and bcl2. |
2022-05-13 |
2023-08-13 |
Not clear |
| Vrutti V Mehta, Kenza E Benzeroua. Cucurbitacin B and Evodiamine imparts anti-neoplastic effects against Glioblastoma Multiforme via PI3-K/AKT signaling pathway. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35557445. |
in addition, cells treated with cub and evo showed a decrease in bcl2, an anti-apoptotic factor, and an increase in bax, a pro-apoptotic factor, expression; a hallmark of induction of apoptosis. |
2022-05-13 |
2023-08-13 |
human |
| Kai Wang, Jing Dai, Tao Liu, Qiong Wang, Yingxu Pan. Retracted Article: LncRNA ZEB2-AS1 regulates the drug resistance of acute myeloid leukemia RSC advances. vol 9. issue 67. 2022-05-11. PMID:35540690. |
western blotting was applied to analyze levels of bcl2 apoptosis regulator (bcl-2), bcl2 associated x, apoptosis regulator (bax), cleaved-caspase-3 and inpp4b. |
2022-05-11 |
2023-08-13 |
Not clear |
| An-Qi Zhang, Lu Wang, Yi-Xiu Wang, Shan-Shan Hong, Yu-Shan Zhong, Ru-Yi Yu, Xin-Lu Wu, Bing-Bing Zhou, Qi-Min Yu, Hai-Feng Fu, Shuang-Dong Chen, Yun-Chang Mo, Qin-Xue Dai, Jun-Lu Wan. Silencing miRNA-324-3p protects against cerebral ischemic injury via regulation of the GATA2/A1R axis. Neural regeneration research. vol 17. issue 11. 2022-05-10. PMID:35535903. |
in a pc12 cell oxygen-glucose deprivation/reoxygenation model, a mir-324-3p mimic decreased cell viability and expression of the anti-apoptotic protein bcl2 and increased expression of the pro-apoptotic protein bax and rates of cell apoptosis, whereas treatment with a mir-324-3p inhibitor had the opposite effects. |
2022-05-10 |
2023-08-13 |
rat |
| Xiangyun Zhu, Dechen Liu, Guoqing Li, Mengmeng Zhi, Ji Sun, Liang Qi, Jingbo Li, Stephen J Pandol, Ling L. Exosomal miR-140-3p and miR-143-3p from TGF-β1-treated pancreatic stellate cells target BCL2 mRNA to increase β-cell apoptosis. Molecular and cellular endocrinology. 2022-05-05. PMID:35513284. |
exosomal mir-140-3p and mir-143-3p from tgf-β1-treated pancreatic stellate cells target bcl2 mrna to increase β-cell apoptosis. |
2022-05-05 |
2023-08-13 |
Not clear |
| E A Klimov, V V Sobolev, N A Batashkov, Z G Kokaeva, A V Tretiakov, Z A Nevozinskaya, I M Korsunskaya, T N Sukhova, O E Evina, A Z Khashukoev. Transcriptional Activity of Some Genes Involved in Apoptosis in Patients with Vulvar Lichen Sclerosus. Bulletin of experimental biology and medicine. 2022-05-02. PMID:35501640. |
we assessed the level of transcriptional activity of apaf1, bax, bcl2, birc5, ccnd1, dapk1, mcl1, and myc genes encoding products that control apoptosis in the samples of tissues affected by vulvar lichen sclerosus and adjacent control tissues (n=24). |
2022-05-02 |
2023-08-13 |
Not clear |
| Doneti Ravinder, Shailima Rampogu, Gangappa Dharmapuri, Akbar Pasha, Keun Woo Lee, Smita C Pawa. Inhibition of DDX3 and COX-2 by forskolin and evaluation of anti-proliferative, pro-apoptotic effects on cervical cancer cells: molecular modelling and in vitro approaches. Medical oncology (Northwood, London, England). vol 39. issue 5. 2022-04-28. PMID:35478276. |
the fsk treatment also significantly induced apoptosis in cancer cells by modulating the expression of apoptotic markers like caspase-3, cleaved caspase-3, caspase-9, cleaved caspase-9, full length-poly adp ribose polymerase (parp), cleaved-poly adp ribose polymerase (c-parp) and bcl2 in dose dependent manner. |
2022-04-28 |
2023-08-13 |
Not clear |
| Takeshi Moriishi, Toshihisa Komor. Osteocytes: Their Lacunocanalicular Structure and Mechanoresponses. International journal of molecular sciences. vol 23. issue 8. 2022-04-23. PMID:35457191. |
osteoblast-specific bcl2 transgenic mice were found to have a reduced number of osteocyte processes and canaliculi, which caused massive osteocyte apoptosis and a completely interrupted lacunocanalicular network. |
2022-04-23 |
2023-08-13 |
mouse |
| Yunbing Tang, Yingfen Ying, Cheng Zou, Haoni Yan, Yiyan Wang, Huitao Li, Xiaoheng Li, Zhangye Xu, Jieqiang Lv, Ren-Shan G. Leydig cell function in adult male rats is disrupted by perfluorotetradecanoic acid through increasing oxidative stress and apoptosis. Environmental toxicology. 2022-04-06. PMID:35385208. |
pfteda markedly increased testicular malondialdehyde level, while inhibiting antioxidants (sod1, sod2, and cat), triggering oxidative stress, thereby further inducing bax and casp3 while inhibiting bcl2, which led to cell apoptosis. |
2022-04-06 |
2023-08-13 |
rat |
| Xin Yan, Deyun Chen, Yao Wang, Yelei Guo, Chuan Tong, Jianshu Wei, Yajing Zhang, Zhiqiang Wu, Weidong Ha. Identification of NOXA as a pivotal regulator of resistance to CAR T-cell therapy in B-cell malignancies. Signal transduction and targeted therapy. vol 7. issue 1. 2022-04-04. PMID:35370290. |
here, via an unbiased genome-wide crispr/cas9 screening, we identified loss of noxa, a b-cell lymphoma 2 (bcl2) family protein in b-cell malignancies, as a pivotal regulator of resistance to car t-cell therapy by impairing apoptosis of tumor cells both in vitro and in vivo. |
2022-04-04 |
2023-08-13 |
Not clear |
| Vishal Kumar Gupta, Ajay Kuma. Targeting lysophosphatidic acid receptor with Ki16425 impedes T cell lymphoma progression through apoptosis induction, glycolysis inhibition, and activation of antitumor immune response. Apoptosis : an international journal on programmed cell death. 2022-04-02. PMID:35366141. |
the administration of ki16425 triggered apoptosis by down-regulating the expression of bcl2 and up-regulating p53, bax, cleaved caspase-3, and cyt c expression. |
2022-04-02 |
2023-08-13 |
Not clear |
| Duohui Zhou, Zhongli Dai, Mingde Ren, Mingyuan Yan. Adipose-Derived Stem Cells-Derived Exosomes with High Amounts of Circ_0001747 Alleviate Hypoxia/Reoxygenation-Induced Injury in Myocardial Cells by Targeting MiR-199b-3p/MCL1 Axis. International heart journal. vol 63. issue 2. 2022-03-31. PMID:35354755. |
dual-luciferase reporter assay and rna immunoprecipitation assay were conducted to confirm the interaction between microrna-199b-3p (mir-199b-3p) and circ_0001747 or mcl1 apoptosis regulator, bcl2 family member (mcl1).h/r-induced hl-1 dysfunction was attenuated by the incubation of exosomes derived from adscs, especially the exosomes with high amounts of circ_0001747. |
2022-03-31 |
2023-08-13 |
mouse |
| Xiangyang Zhang, Min Wang, Junyi Feng, Bin Qin, Chenglin Zhang, Chengshen Zhu, Wentao Liu, Yaohe Wang, Wei Liu, Lei Huang, Shuangshuang Lu, Zhimin Wan. Multifunctional nanoparticles co-loaded with Adriamycin and MDR-targeting siRNAs for treatment of chemotherapy-resistant esophageal cancer. Journal of nanobiotechnology. vol 20. issue 1. 2022-03-29. PMID:35346194. |
we have designed a novel and versatile self-assembling nanoparticle (np) platform on a multifunctional carboxymethyl chitosan base to simultaneously deliver adriamycin, and sirnas targeting mvp and bcl2 (ceamb nps), thus reducing drug efflux and promoting apoptosis of esophageal cancer cells. |
2022-03-29 |
2023-08-13 |
mouse |
| Hai Duc Nguyen, Min-Sun Ki. Exposure to a mixture of heavy metals induces cognitive impairment: genes and microRNAs involved. Toxicology. 2022-03-29. PMID:35346790. |
the mixed heavy metals altered the genes bax, casp3, bcl2, tnf, and il-1b, indicating the significance of apoptosis and pro-inflammatory cytokines in the pathogenesis of cognitive impairment and the possibility of targeting these genes in future neuroprotective therapy. |
2022-03-29 |
2023-08-13 |
Not clear |
| Krishna Madhavan, Ilango Balakrishnan, Senthilnath Lakshmanachetty, Angela Pierce, Bridget Sanford, Susan Fosmire, Hanan B Elajaili, Faye Walker, Dong Wang, Eva S Nozik, Siddhartha S Mitra, Nathan A Dahl, Rajeev Vibhakar, Sujatha Venkatarama. Venetoclax cooperates with ionizing radiation to attenuate Diffuse Midline Glioma tumor growth. Clinical cancer research : an official journal of the American Association for Cancer Research. 2022-03-28. PMID:35344040. |
rt-induced stress increases association of bcl2 family of proteins with bh3 pro-apoptotic activators preventing apoptosis. |
2022-03-28 |
2023-08-13 |
Not clear |
| Krishna Madhavan, Ilango Balakrishnan, Senthilnath Lakshmanachetty, Angela Pierce, Bridget Sanford, Susan Fosmire, Hanan B Elajaili, Faye Walker, Dong Wang, Eva S Nozik, Siddhartha S Mitra, Nathan A Dahl, Rajeev Vibhakar, Sujatha Venkatarama. Venetoclax cooperates with ionizing radiation to attenuate Diffuse Midline Glioma tumor growth. Clinical cancer research : an official journal of the American Association for Cancer Research. 2022-03-28. PMID:35344040. |
we hypothesized that inhibition of rt-induced bcl2 with a clinically relevant inhibitor, venetoclax, will block bcl2 activity leading to increased apoptosis. |
2022-03-28 |
2023-08-13 |
Not clear |
| Yingwei Liu, Jiangnan Yi, Yuanliang Li, Riaz Hussain, Shanshan Zhu, Yangwei Li, Zhuanxu Ouyang, Khalid Mehmood, Lianmei Hu, Jiaqing Pan, Zhaoxin Tang, Ying Li, Hui Zhan. Residue of thiram in food, suppresses immune system stress signals and disturbs sphingolipid metabolism in chickens. Veterinary immunology and immunopathology. vol 247. 2022-03-28. PMID:35344810. |
results indicated significantly decreased expression of m-tor and bcl2 to activate apoptosis and autophagy. |
2022-03-28 |
2023-08-13 |
mouse |