| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Souvik Roy, Anil Kumar Mondru, Tania Chakraborty, Abhijit Das, Sandipan Dasgupt. Apple polyphenol phloretin complexed with ruthenium is capable of reprogramming the breast cancer microenvironment through modulation of PI3K/Akt/mTOR/VEGF pathways. Toxicology and applied pharmacology. 2021-12-13. PMID:34896434. |
ruthenium-phloretin complex could modulate p53 intervene apoptosis in the breast carcinoma, initiated by the trail of intrinsic apoptosis facilitated through bcl2 and bax and at the same time down regulating the pi3k/akt/mtor pathway coupled with mmp9 regulated tumor invasive pathways. |
2021-12-13 |
2023-08-13 |
human |
| Ying He, Wei Wang, Xiaoxiao Xu, Beining Yang, Xijie Yu, Yanru Wu, Jiawei Wan. Mettl3 inhibits the apoptosis and autophagy of chondrocytes in inflammation through mediating Bcl2 stability via Ythdf1-mediated m Bone. vol 154. 2021-12-11. PMID:34530171. |
mettl3 inhibits the apoptosis and autophagy of chondrocytes in inflammation through mediating bcl2 stability via ythdf1-mediated m n |
2021-12-11 |
2023-08-13 |
Not clear |
| Yi Liu, Jing Guo, June Zhang, Yunyun Deng, Guanghua Xiong, Jianpin Fu, Lili Wei, Huiqiang L. Chlorogenic acid alleviates thioacetamide-induced toxicity and promotes liver development in zebrafish (Danio rerio) through the Wnt signaling pathway. Aquatic toxicology (Amsterdam, Netherlands). vol 242. 2021-12-10. PMID:34856462. |
the results of western blotting analysis showed that cga inhibited cell apoptosis by increasing the levels of bcl2 apoptosis regulator and decreasing the levels of bcl2 associated x (bax), apoptosis regulator and tumor protein p53. |
2021-12-10 |
2023-08-13 |
cat |
| Laura E Sperl, Florian Rührnößl, Anita Schiller, Martin Haslbeck, Franz Hag. High-resolution analysis of the conformational transition of pro-apoptotic Bak at the lipid membrane. The EMBO journal. vol 40. issue 20. 2021-12-08. PMID:34523144. |
permeabilization of the outer mitochondrial membrane by pore-forming bcl2 proteins is a crucial step for the induction of apoptosis. |
2021-12-08 |
2023-08-13 |
Not clear |
| Darko Maric, Aleksandra Paterek, Marion Delaunay, Irene Pérez López, Miroslav Arambasic, Dario Divian. A-Kinase Anchoring Protein 2 Promotes Protection against Myocardial Infarction. Cells. vol 10. issue 11. 2021-12-08. PMID:34831084. |
this results in the upregulation of er-dependent genes involved in protection against apoptosis and angiogenesis, including bcl2 and the vascular endothelial growth factor a (vegfa). |
2021-12-08 |
2023-08-13 |
mouse |
| Darko Maric, Aleksandra Paterek, Marion Delaunay, Irene Pérez López, Miroslav Arambasic, Dario Divian. A-Kinase Anchoring Protein 2 Promotes Protection against Myocardial Infarction. Cells. vol 10. issue 11. 2021-12-08. PMID:34831084. |
in line with these findings, cardiomyocyte-specific akap2 ko reduces bcl2 and vegfa expression, increases myocardial apoptosis and impairs the formation of new blood vessels in infarcted hearts. |
2021-12-08 |
2023-08-13 |
mouse |
| Hang Hu, Xinshan Zhao, Yalei Cui, Shengkang Li, Yi Gon. SpTIA-1 suppresses WSSV infection by promoting apoptosis in mud crab (Scylla paramamosain). Molecular immunology. vol 140. 2021-12-07. PMID:34715578. |
tia-1 (t cell restricted intracellular antigen-1) is a kind of rna-binding protein which serves as the downstream of ced-9 (a bcl2 homolog) and induces apoptosis under stress conditions. |
2021-12-07 |
2023-08-13 |
Not clear |
| Wulan Koagouw, Richard J Hazell, Corina Cioca. Induction of apoptosis in the gonads of Mytilus edulis by metformin and increased temperature, via regulation of HSP70, CASP8, BCL2 and FAS. Marine pollution bulletin. vol 173. issue Pt A. 2021-12-06. PMID:34649205. |
induction of apoptosis in the gonads of mytilus edulis by metformin and increased temperature, via regulation of hsp70, casp8, bcl2 and fas. |
2021-12-06 |
2023-08-13 |
Not clear |
| Wulan Koagouw, Richard J Hazell, Corina Cioca. Induction of apoptosis in the gonads of Mytilus edulis by metformin and increased temperature, via regulation of HSP70, CASP8, BCL2 and FAS. Marine pollution bulletin. vol 173. issue Pt A. 2021-12-06. PMID:34649205. |
conversely, metformin may induce apoptosis by suppressing the anti-apoptotic gene bcl2, thus promoting the process. |
2021-12-06 |
2023-08-13 |
Not clear |
| A Wnuk, K Przepiórska, B A Pietrzak, M Kajt. Posttreatment Strategy Against Hypoxia and Ischemia Based on Selective Targeting of Nonnuclear Estrogen Receptors with PaPE-1. Neurotoxicity research. vol 39. issue 6. 2021-12-04. PMID:34797527. |
the mechanisms of the neuroprotective action of pape-1 also involved apoptosis inhibition demonstrated by normalization of both mitochondrial membrane potential and expression levels of apoptosis-related genes and proteins such as fas, fasl, bcl2, fas, fasl, bcl2, bax, and gsk3β. |
2021-12-04 |
2023-08-13 |
mouse |
| Xiuli Zhang, Ruqing Gao, Huiyu Yan, Zijian Zhao, Jun Zhang, Weiming Yo. Assembling BH3-mimic peptide into a nanocluster to target intracellular Bcl2 towards the apoptosis induction of cancer cell. Nanotechnology. vol 33. issue 8. 2021-12-03. PMID:34261054. |
assembling bh3-mimic peptide into a nanocluster to target intracellular bcl2 towards the apoptosis induction of cancer cell. |
2021-12-03 |
2023-08-13 |
Not clear |
| Paola Fernandes Pansini, Isabella Bittencourt do Valle, Thabata Coeli Dias Damasceno, Priscila Marinho de Abreu, Anna Clara Gregório Có, Rossana Verónica Mendoza López, Jeferson Lenzi, Ricardo Mai Rocha, Evandro Duccini Souza, Maria Paula Curado, Hisham Mehanna, Paul Nankivell, José Roberto Vasconcelos de Podestá, Sandra Ventorin von Zeidle. Differential Expression of Potential Biomarkers of Oral Squamous Cell Carcinoma Development. Head and neck pathology. vol 15. issue 4. 2021-12-01. PMID:33840043. |
to evaluate molecular epithelial changes, we investigated whether a profile of survivin, cyclin dependent kinase inhibitor 2a (cdkn2a), epidermal growth factor receptor (egfr), polo like kinase 1 (plk1), p63, p40 (Δnp63 isoform), cyclin d1 (ccnd1) and bcl2 apoptosis regulator (bcl2) proteins could predict malignant transformation. |
2021-12-01 |
2023-08-13 |
Not clear |
| Gabriel Prado, Charlotte L Kaestner, Jonathan D Licht, Richard L Bennet. Targeting epigenetic mechanisms to overcome venetoclax resistance. Biochimica et biophysica acta. Molecular cell research. vol 1868. issue 8. 2021-11-29. PMID:33945824. |
the bh-3 mimetic venetoclax overcomes apoptosis and therapy resistance caused by high expression of bcl2 or loss of bh3-only protein function. |
2021-11-29 |
2023-08-13 |
human |
| Andrew W Roberts, Andrew H Wei, David C S Huan. BCL2 and MCL1 inhibitors for hematologic malignancies. Blood. vol 138. issue 13. 2021-11-29. PMID:34320168. |
bh3 mimetics act by inhibiting the prosurvival bcl2 proteins to enable the activation of bax and bak, apoptosis effectors that permeabilize the outer mitochondrial membrane, triggering apoptosis directly in many cells and sensitizing others to cell death when combined with other antineoplastic drugs. |
2021-11-29 |
2023-08-13 |
Not clear |
| Yun Yu, Long-Long Hu, Liang Liu, Ling-Ling Yu, Jun-Pei Li, Jing-An Rao, Ling-Juan Zhu, Hui-Hui Bao, Xiao-Shu Chen. Hsp22 ameliorates lipopolysaccharide-induced myocardial injury by inhibiting inflammation, oxidative stress, and apoptosis. Bioengineered. 2021-11-29. PMID:34839787. |
in addition, superoxide dismutase (sod) activity and b-cell lymphoma-2 (bcl2) levels were augmented by hsp22 treatment resulting in lowering of lps-induced oxidative stress and cardiomyocyte apoptosis. |
2021-11-29 |
2023-08-13 |
mouse |
| Peramaiyan Rajendran, Abdullah M Alzahrani, Vishnu Priya Veeraraghavan, Emad A Ahme. Anti-Apoptotic Effect of Flavokawain A on Ochratoxin-A-Induced Endothelial Cell Injury by Attenuation of Oxidative Stress via PI3K/AKT-Mediated Nrf2 Signaling Cascade. Toxins. vol 13. issue 11. 2021-11-28. PMID:34822529. |
in addition, fka enhanced bcl2 activation while suppressing apoptosis marker proteins. |
2021-11-28 |
2023-08-13 |
Not clear |
| Jyoti B Kaushal, Rakesh Bhatia, Ranjana K Kanchan, Pratima Raut, Surya Mallapragada, Quan P Ly, Surinder K Batra, Satyanarayana Rachagan. Repurposing Niclosamide for Targeting Pancreatic Cancer by Inhibiting Hh/Gli Non-Canonical Axis of Gsk3β. Cancers. vol 13. issue 13. 2021-11-27. PMID:34206370. |
mechanistically, nic inhibited the interaction between bcl2 and beclin-1 that supported the crosstalk of autophagy and apoptosis. |
2021-11-27 |
2023-08-13 |
Not clear |
| Zahra Yazdani, Pooyan Mehrabanjoubani, Alireza Rafiei, Pourya Biparva, Mostafa Karda. Combined Effect of Cold Atmospheric Plasma and Curcumin in Melanoma Cancer. BioMed research international. vol 2021. 2021-11-27. PMID:34825002. |
in addition, the activation of apoptosis pathways was evaluated using bcl2, bax, and caspase-3 (casp3) gene expression and ratio of bax to bcl2 (bax/bcl2). |
2021-11-27 |
2023-08-13 |
Not clear |
| Yong Guo, Fang-Fang Wang, Bing Xiang, Hong-Bing Ma, Yu-Ping Gon. Tanshinone IIA potentiates the efficacy of imatinib by regulating the AKT-MDM2-P53 signaling pathway in Philadelphia chromosome-positive acute lymphoblastic leukemia. Oncology letters. vol 23. issue 1. 2021-11-26. PMID:34820006. |
the present study revealed that tanshinone iia markedly potentiated the cytotoxic and apoptotic induction effects of imatinib by regulating the akt-mdm2-p53 signaling pathway and inhibiting the anti-apoptotic proteins bcl2 and mcl1 apoptosis regulator, bcl2 family member in ph+ all cell lines. |
2021-11-26 |
2023-08-13 |
Not clear |
| Aishwarya Payapilly, Ryan Guilbert, Tine Descamps, Gavin White, Peter Magee, Cong Zhou, Alastair Kerr, Kathryn L Simpson, Fiona Blackhall, Caroline Dive, Angeliki Mallir. TIAM1-RAC1 promote small-cell lung cancer cell survival through antagonizing Nur77-induced BCL2 conformational change. Cell reports. vol 37. issue 6. 2021-11-25. PMID:34758330. |
tiam1 depletion or rac1 inhibition reduces viability and tumorigenicity of sclc cells by increasing apoptosis associated with conversion of bcl2 from its pro-survival to pro-apoptotic function via bh3 domain exposure. |
2021-11-25 |
2023-08-13 |
Not clear |