| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Meng Song, Xueping Ou, Cuicui Xiao, Zhongming Xiao, Fang Wei, Yan Hon. Hedgehog signaling inhibitor cyclopamine induces apoptosis by decreasing Gli2 and Bcl2 expression in human salivary pleomorphic adenoma cells. Biomedical reports. vol 1. issue 2. 2021-10-21. PMID:24648943. |
the aim of this study was to investigate the effect of cyclopamine induction apoptosis in human salivary pleomorphic adenoma (hspa) cells and the impact on gli2 and bcl2 mrna levels. |
2021-10-21 |
2023-08-12 |
human |
| Mahnoush Kolahdouz, Faranak Jafari, Farahnaz Falanji, Samad Nazemi, Mohammad Mohammadzadeh, Mehdi Molavi, Bahareh Ami. Clavulanic Acid Attenuating Effect on the Diabetic Neuropathic Pain in Rats. Neurochemical research. vol 46. issue 7. 2021-10-18. PMID:33846883. |
the expression of the glutamate transport 1 (glt1), genes of oxidative stress including inducible nitric oxide synthase (inos), proinflammatory cytokine, tumor necrosis factor alpha (tnf-α), as well as genes involved in the apoptosis including bcl2, bcl2-associated x (bax) were measured in the spinal cord tissue by real time pcr, on day 42. |
2021-10-18 |
2023-08-13 |
rat |
| Bin Xu, Shu-Cheng Zang, Li-Min Lang, Shuai Lian, Jingjing Lu, Shi-Ze Li, Huan-Min Yang, Li Zhe. Down-regulation of miR-383-5p suppresses apoptosis in oxidative stress rat hepatocytes by targeting Bcl2. Journal of animal physiology and animal nutrition. vol 104. issue 6. 2021-10-15. PMID:32090391. |
down-regulation of mir-383-5p suppresses apoptosis in oxidative stress rat hepatocytes by targeting bcl2. |
2021-10-15 |
2023-08-13 |
rat |
| Milirani Das, Lalrawngbawli Annie, Kira V Derkach, Alexander O Shpakov, Guruswami Gurusubramanian, Vikas Kumar Ro. Expression and localization of apelin and its receptor in the testes of diabetic mice and its possible role in steroidogenesis. Cytokine. vol 144. 2021-10-15. PMID:33962842. |
the diabetic testes had a decrease in germ cell proliferation (the reduced pcna and gcna levels) and an increase in apoptosis (the increased active caspase-3 and decreased bcl2 levels). |
2021-10-15 |
2023-08-13 |
mouse |
| Jie Shi, Shaoyi Wang, Qiting He, Kaiwen Liu, Wei Zhao, Qing Xie, Lei Chen. TNF-α induces up-regulation of MicroRNA-27a via the P38 signalling pathway, which inhibits intervertebral disc degeneration by targeting FSTL1. Journal of cellular and molecular medicine. vol 25. issue 15. 2021-10-15. PMID:34190406. |
apoptosis of nucleus pulposus cells was detected by flow cytometry and bcl2, bax and caspase 3. |
2021-10-15 |
2023-08-13 |
human |
| Hai-Fan Yu, Lian-Wen Zheng, Zhan-Qing Yang, Yu-Si Wang, Ting-Ting Wang, Zhan-Peng Yue, Bin Gu. TAZ as a novel regulator of oxidative damage in decidualization via Nrf2/ARE/Foxo1 pathway. Experimental & molecular medicine. vol 53. issue 9. 2021-10-15. PMID:34497345. |
moreover, taz prevented stromal cell apoptosis by upregulating bcl2 expression and inhibiting casp3 activity and bax expression. |
2021-10-15 |
2023-08-13 |
Not clear |
| Hui Bai, Tingting Li, Yan Yu, Ningcong Zhou, Huijuan Kou, Yingying Guo, Liang Yang, Peishi Ya. Cytoprotective Effects of Taurine on Heat-Induced Bovine Mammary Epithelial Cells In Vitro. Cells. vol 10. issue 2. 2021-10-14. PMID:33525569. |
taurine also alleviated the rates of cell apoptosis and markedly depressed the mrna expressions of bcl2 associated x, apoptosis regulator (bax) and caspase3. |
2021-10-14 |
2023-08-13 |
cattle |
| Chien-Yu Huang, Yu-Jia Chang, Po-Li Wei, Chin-Sheng Hung, Weu Wan. Methyl gallate, gallic acid-derived compound, inhibit cell proliferation through increasing ROS production and apoptosis in hepatocellular carcinoma cells. PloS one. vol 16. issue 3. 2021-10-13. PMID:33725002. |
the western blot analysis showed that mg activated cleavage of caspase-3 and poly (sdp ribose) polymerase (parp), modulated levels of the bcl2, bax, and bad ligands, and induced apoptosis. |
2021-10-13 |
2023-08-13 |
human |
| Ayan Mondal, Punnag Saha, Dipro Bose, Somdatta Chatterjee, Ratanesh K Seth, Shuo Xiao, Dwayne E Porter, Bryan W Brooks, Geoff I Scott, Mitzi Nagarkatti, Prakash Nagarkatti, Saurabh Chatterje. Environmental Microcystin exposure in underlying NAFLD-induced exacerbation of neuroinflammation, blood-brain barrier dysfunction, and neurodegeneration are NLRP3 and S100B dependent. Toxicology. vol 461. 2021-10-13. PMID:34416350. |
mechanistically, conditioned medium from reactive astrocytes and parallel s100b incubation in neuronal cells caused increased inducible nos, cox-2, and higher bax/ bcl2 protein expression suggesting oxidative stress-mediated neuronal cell apoptosis crucial for neurodegeneration. |
2021-10-13 |
2023-08-13 |
mouse |
| M S Araujo, M D Guastali, F Paulini, A N Silva, M H Tsunemi, P K Fontes, A C S Castilho, F C Landim-Alvareng. Molecular and cellular effects of insulin-like growth factor-1 and LongR3-IGF-1 on in vitro maturation of bovine oocytes: comparative study. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. vol 55. 2021-10-12. PMID:33038561. |
addition effects of insulin-like growth factor-1 (igf-1) and its synthetic analogue insulin-like growth factor-1 recombinant-3 (longr3-igf-1) after in vitro maturation (ivm) of cattle cumulus-oocyte complexes (cocs) were compared and evaluated on meiotic progression, apoptosis and profile genes of oocyte competence (gdf9, bmp15, bax, bcl2, oosp1, igfbp2, igbfp4 and igfbp5), and their respective cumulus cells (areg, egfr, fshr, cox2, bax, bcl2, igfbp2, igfbp4 and igfbp5). |
2021-10-12 |
2023-08-13 |
cattle |
| Ping Zhong, Jin Liu, Hong Li, Senbin Lin, Lingfeng Zeng, Lingfeng Luo, Minxia Wu, Wenchang Zhan. MicroRNA-204-5p regulates apoptosis by targeting Bcl2 in rat ovarian granulosa cells exposed to cadmium†. Biology of reproduction. vol 103. issue 3. 2021-10-11. PMID:32500147. |
microrna-204-5p regulates apoptosis by targeting bcl2 in rat ovarian granulosa cells exposed to cadmium†. |
2021-10-11 |
2023-08-13 |
rat |
| Ping Zhong, Jin Liu, Hong Li, Senbin Lin, Lingfeng Zeng, Lingfeng Luo, Minxia Wu, Wenchang Zhan. MicroRNA-204-5p regulates apoptosis by targeting Bcl2 in rat ovarian granulosa cells exposed to cadmium†. Biology of reproduction. vol 103. issue 3. 2021-10-11. PMID:32500147. |
in addition, cd promoted apoptosis by decreasing the mrna and protein expression levels of inhibition of b-cell lymphoma 2 (bcl2). |
2021-10-11 |
2023-08-13 |
rat |
| Sandhya Yadav, Deepak Pant, Atul Samaiya, Neetu Kalra, Sanjay Gupta, Sanjeev Shukl. ERK1/2-EGR1-SRSF10 Axis Mediated Alternative Splicing Plays a Critical Role in Head and Neck Cancer. Frontiers in cell and developmental biology. vol 9. 2021-10-08. PMID:34616729. |
we observed that srsf10 plays a crucial role in hnc tumorigenesis by affecting the pro-death, pro-survical splice variants of bcl2l1 (bcl2 like 1: bclx: apoptosis regulator) and the two splice variants of pkm (pyruvate kinase m), pkm1 normal isoform to pkm2 cancer-specific isoform. |
2021-10-08 |
2023-08-13 |
Not clear |
| Vicente Fresquet, Maria J Garcia-Barchino, Marta Larrayoz, Jon Celay, Carmen Vicente, Marta Fernandez-Galilea, Maria J Larrayoz, Maria J Calasanz, Carlos Panizo, Alexandra Junza, Jiahuai Han, Celia Prior, Puri Fortes, Ruben Pio, Julen Oyarzabal, Alvaro Martinez-Baztan, Bruno Paiva, Maria J Moreno-Aliaga, Maria D Odero, Xabier Agirre, Oscar Yanes, Felipe Prosper, Jose A Martinez-Climen. Endogenous Retroelement Activation by Epigenetic Therapy Reverses the Warburg Effect and Elicits Mitochondrial-Mediated Cancer Cell Death. Cancer discovery. vol 11. issue 5. 2021-10-07. PMID:33355179. |
to maintain atp generation, hyperactive mitochondrial membrane blocks intrinsic apoptosis by increasing bcl2 dependency. |
2021-10-07 |
2023-08-13 |
Not clear |
| Praveen Kumar Reddy Nagireddy, Dinesh Kumar, Vamsi Krishna Kommalapati, Ravi Kumar Pedapati, Venkateswarlu Kojja, Anjana Devi Tangutur, Srinivas Kantevar. 9-Ethynyl noscapine induces G2/M arrest and apoptosis by disrupting tubulin polymerization in cervical cancer. Drug development research. 2021-10-06. PMID:34612529. |
we also observed that 9-ethynyl noscapine (5) treatment leads to disruption in tubulin polymerization and induction of apoptosis by decreasing expression of bcl2, pro-caspase 3, and activation of cytochrome c. taken together, our results indicate that 9-ethynyl noscapine (5) effectively supresses the growth of cervical cancer cells (hela) by disrupting tubulin polymerization, cell cycle progression leading to apoptosis. |
2021-10-06 |
2023-08-13 |
human |
| Liang Wei, Cheng Yang, Guangxue Wang, Keqin Li, Yanfei Zhang, Hongxin Guan, Zhiyang Sun, Chunlong Zhon. Interleukin Enhancer Binding Factor 2 Regulates Cell Viability and Apoptosis of Human Brain Vascular Smooth Muscle Cells. Journal of molecular neuroscience : MN. vol 71. issue 2. 2021-10-05. PMID:32748330. |
rt-qpcr results showed that ilf2 knock-down downregulated the expression levels of bcl2 apoptosis regulator (bcl2), transcriptional regulator myc-like (c-myc), and caspase 1 (ice) whereas upregulated the expression levels of cd95, p21, p53, and interleukin-13 (il-13). |
2021-10-05 |
2023-08-13 |
human |
| Rui Liang, Mingo M H Yung, Fangfang He, Peili Jiao, Karen K L Chan, Hextan Y S Ngan, David W Cha. The Stress-Inducible BCL2A1 Is Required for Ovarian Cancer Metastatic Progression in the Peritoneal Microenvironment. Cancers. vol 13. issue 18. 2021-10-01. PMID:34572804. |
under stress conditions, bcl2a1 accumulated and colocalized with mitochondria to suppress intrinsic cell apoptosis by interacting with the bh3-only subfamily bcl2 members hrk/bad/bid in ovarian cancer cells. |
2021-10-01 |
2023-08-13 |
Not clear |
| Jingang Sun, Cuicui Zhang, Zhigang Zhan. Atorvastatin attenuates cardiac hypertrophy through AMPK/miR-143-3p/Bcl2 axis. Archives of physiology and biochemistry. vol 127. issue 5. 2021-09-30. PMID:31353965. |
taken together, the data indicated that mir-143-3p aggravated cardiac hypertrophy by inducing cardiomyocytes apoptosis through inhibiting bcl2 expression. |
2021-09-30 |
2023-08-13 |
rat |
| Clémentine Sarkozy, Stacy S Hung, Elizabeth A Chavez, Gerben Duns, Katsuyoshi Takata, Lauren C Chong, Tomohiro Aoki, Aixiang Jiang, Tomoko Miyata-Takata, Adèle Telenius, Graham W Slack, Thierry Jo Molina, Susana Ben-Neriah, Pedro Farinha, Peggy Dartigues, Diane Damotte, Anja Mottok, Gilles A Salles, Rene-Olivier Casasnovas, Kerry J Savage, Camille Laurent, David W Scott, Alexandra Traverse-Glehen, Christian Steid. Mutational landscape of gray zone lymphoma. Blood. vol 137. issue 13. 2021-09-27. PMID:32961552. |
in contrast, gzl cases without thymic niche involvement (n = 18) had a significantly distinct pattern that was enriched in mutations related to apoptosis defects (tp53 [39%], bcl2 [28%], birc6 [22%]) and depleted in gna13, xpo1, or nf-κb signaling pathway mutations (tnfaip3, nfkbie, ikbkb, nfkbia). |
2021-09-27 |
2023-08-13 |
Not clear |
| Lili Tan, Limin Liu, Jian Yao, Chenghao Pia. miR-145-5p attenuates inflammatory response and apoptosis in myocardial ischemia-reperfusion injury by inhibiting (NADPH) oxidase homolog 1. Experimental animals. vol 70. issue 3. 2021-09-27. PMID:33658472. |
upregulation of mir-145-5p increased cell viability and reduced apoptosis accompanied by downregulation of bax, cleaved caspase-3, cleaved poly(adp-ribose) polymerase (parp) and upregulation of bcl2. |
2021-09-27 |
2023-08-13 |
rat |