| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Wnuk, K Przepiórska, B A Pietrzak, M Kajt. Posttreatment Strategy Against Hypoxia and Ischemia Based on Selective Targeting of Nonnuclear Estrogen Receptors with PaPE-1. Neurotoxicity research. vol 39. issue 6. 2021-12-04. PMID:34797527. |
the mechanisms of the neuroprotective action of pape-1 also involved apoptosis inhibition demonstrated by normalization of both mitochondrial membrane potential and expression levels of apoptosis-related genes and proteins such as fas, fasl, bcl2, fas, fasl, bcl2, bax, and gsk3β. |
2021-12-04 |
2023-08-13 |
mouse |
| Xiuli Zhang, Ruqing Gao, Huiyu Yan, Zijian Zhao, Jun Zhang, Weiming Yo. Assembling BH3-mimic peptide into a nanocluster to target intracellular Bcl2 towards the apoptosis induction of cancer cell. Nanotechnology. vol 33. issue 8. 2021-12-03. PMID:34261054. |
assembling bh3-mimic peptide into a nanocluster to target intracellular bcl2 towards the apoptosis induction of cancer cell. |
2021-12-03 |
2023-08-13 |
Not clear |
| Paola Fernandes Pansini, Isabella Bittencourt do Valle, Thabata Coeli Dias Damasceno, Priscila Marinho de Abreu, Anna Clara Gregório Có, Rossana Verónica Mendoza López, Jeferson Lenzi, Ricardo Mai Rocha, Evandro Duccini Souza, Maria Paula Curado, Hisham Mehanna, Paul Nankivell, José Roberto Vasconcelos de Podestá, Sandra Ventorin von Zeidle. Differential Expression of Potential Biomarkers of Oral Squamous Cell Carcinoma Development. Head and neck pathology. vol 15. issue 4. 2021-12-01. PMID:33840043. |
to evaluate molecular epithelial changes, we investigated whether a profile of survivin, cyclin dependent kinase inhibitor 2a (cdkn2a), epidermal growth factor receptor (egfr), polo like kinase 1 (plk1), p63, p40 (Δnp63 isoform), cyclin d1 (ccnd1) and bcl2 apoptosis regulator (bcl2) proteins could predict malignant transformation. |
2021-12-01 |
2023-08-13 |
Not clear |
| Gabriel Prado, Charlotte L Kaestner, Jonathan D Licht, Richard L Bennet. Targeting epigenetic mechanisms to overcome venetoclax resistance. Biochimica et biophysica acta. Molecular cell research. vol 1868. issue 8. 2021-11-29. PMID:33945824. |
the bh-3 mimetic venetoclax overcomes apoptosis and therapy resistance caused by high expression of bcl2 or loss of bh3-only protein function. |
2021-11-29 |
2023-08-13 |
human |
| Andrew W Roberts, Andrew H Wei, David C S Huan. BCL2 and MCL1 inhibitors for hematologic malignancies. Blood. vol 138. issue 13. 2021-11-29. PMID:34320168. |
bh3 mimetics act by inhibiting the prosurvival bcl2 proteins to enable the activation of bax and bak, apoptosis effectors that permeabilize the outer mitochondrial membrane, triggering apoptosis directly in many cells and sensitizing others to cell death when combined with other antineoplastic drugs. |
2021-11-29 |
2023-08-13 |
Not clear |
| Yun Yu, Long-Long Hu, Liang Liu, Ling-Ling Yu, Jun-Pei Li, Jing-An Rao, Ling-Juan Zhu, Hui-Hui Bao, Xiao-Shu Chen. Hsp22 ameliorates lipopolysaccharide-induced myocardial injury by inhibiting inflammation, oxidative stress, and apoptosis. Bioengineered. 2021-11-29. PMID:34839787. |
in addition, superoxide dismutase (sod) activity and b-cell lymphoma-2 (bcl2) levels were augmented by hsp22 treatment resulting in lowering of lps-induced oxidative stress and cardiomyocyte apoptosis. |
2021-11-29 |
2023-08-13 |
mouse |
| Peramaiyan Rajendran, Abdullah M Alzahrani, Vishnu Priya Veeraraghavan, Emad A Ahme. Anti-Apoptotic Effect of Flavokawain A on Ochratoxin-A-Induced Endothelial Cell Injury by Attenuation of Oxidative Stress via PI3K/AKT-Mediated Nrf2 Signaling Cascade. Toxins. vol 13. issue 11. 2021-11-28. PMID:34822529. |
in addition, fka enhanced bcl2 activation while suppressing apoptosis marker proteins. |
2021-11-28 |
2023-08-13 |
Not clear |
| Jyoti B Kaushal, Rakesh Bhatia, Ranjana K Kanchan, Pratima Raut, Surya Mallapragada, Quan P Ly, Surinder K Batra, Satyanarayana Rachagan. Repurposing Niclosamide for Targeting Pancreatic Cancer by Inhibiting Hh/Gli Non-Canonical Axis of Gsk3β. Cancers. vol 13. issue 13. 2021-11-27. PMID:34206370. |
mechanistically, nic inhibited the interaction between bcl2 and beclin-1 that supported the crosstalk of autophagy and apoptosis. |
2021-11-27 |
2023-08-13 |
Not clear |
| Zahra Yazdani, Pooyan Mehrabanjoubani, Alireza Rafiei, Pourya Biparva, Mostafa Karda. Combined Effect of Cold Atmospheric Plasma and Curcumin in Melanoma Cancer. BioMed research international. vol 2021. 2021-11-27. PMID:34825002. |
in addition, the activation of apoptosis pathways was evaluated using bcl2, bax, and caspase-3 (casp3) gene expression and ratio of bax to bcl2 (bax/bcl2). |
2021-11-27 |
2023-08-13 |
Not clear |
| Yong Guo, Fang-Fang Wang, Bing Xiang, Hong-Bing Ma, Yu-Ping Gon. Tanshinone IIA potentiates the efficacy of imatinib by regulating the AKT-MDM2-P53 signaling pathway in Philadelphia chromosome-positive acute lymphoblastic leukemia. Oncology letters. vol 23. issue 1. 2021-11-26. PMID:34820006. |
the present study revealed that tanshinone iia markedly potentiated the cytotoxic and apoptotic induction effects of imatinib by regulating the akt-mdm2-p53 signaling pathway and inhibiting the anti-apoptotic proteins bcl2 and mcl1 apoptosis regulator, bcl2 family member in ph+ all cell lines. |
2021-11-26 |
2023-08-13 |
Not clear |
| Aishwarya Payapilly, Ryan Guilbert, Tine Descamps, Gavin White, Peter Magee, Cong Zhou, Alastair Kerr, Kathryn L Simpson, Fiona Blackhall, Caroline Dive, Angeliki Mallir. TIAM1-RAC1 promote small-cell lung cancer cell survival through antagonizing Nur77-induced BCL2 conformational change. Cell reports. vol 37. issue 6. 2021-11-25. PMID:34758330. |
tiam1 depletion or rac1 inhibition reduces viability and tumorigenicity of sclc cells by increasing apoptosis associated with conversion of bcl2 from its pro-survival to pro-apoptotic function via bh3 domain exposure. |
2021-11-25 |
2023-08-13 |
Not clear |
| Dongfang Dai, Hongping Zhou, Li Yin, Fei Ye, Xiao Yuan, Tao You, Xiaohui Zhao, Weiguo Long, Deqiang Wang, Xia He, Jifeng Feng, Deyu Che. PELI1 promotes radiotherapy sensitivity by inhibiting noncanonical NF-κB in esophageal squamous cancer. Molecular oncology. 2021-11-24. PMID:34738714. |
as a consequence, peli1 inhibited the noncanonical nf-κb-induced expression of the anti-apoptotic gene bcl2 like 1 (bclxl; also known as bcl2l1), leading to an enhancement of the ir-induced apoptosis signaling pathway and ultimately promoting ir-induced apoptosis in tumor cells. |
2021-11-24 |
2023-08-13 |
human |
| Abdullah Al Emran, Hsin-Yi Tseng, Dilini Gunatilake, Stuart J Cook, Farzana Ahmed, Shudong Wang, Peter Hersey, Stuart J Gallagher, Jessamy C Tiffe. A Combination of Epigenetic BET and CDK9 Inhibitors for Treatment of Human Melanoma. The Journal of investigative dermatology. vol 141. issue 9. 2021-11-23. PMID:33781756. |
cell death was associated with mitochondrial depolarization, caspase-dependent apoptosis with cleavage of parp1, and downregulation of anti-apoptotic proteins bcl2, bclxl, and mcl1. |
2021-11-23 |
2023-08-13 |
mouse |
| Jiajie Feng, Jiachen Zhan, Shuangshuang M. LRG1 promotes hypoxia-induced cardiomyocyte apoptosis and autophagy by regulating hypoxia-inducible factor-1α. Bioengineered. vol 12. issue 1. 2021-11-23. PMID:34643170. |
in this study, western blot was applied to detect the protein expression of bax, bcl2, lc3, p62, lrg1 and hypoxia-inducible factor-1α (hif-1α); cck-8 assay was employed to detect cell viability; annexin v-fitc/pi staining was adopted to evaluate apoptosis, and immunofluorescence assay was applied to detect autophagy. |
2021-11-23 |
2023-08-13 |
Not clear |
| Gehad Lotfy, Yasmine M Abdel Aziz, Mohamed M Said, El Sayed H El Ashry, El Sayed H El Tamany, Marwa M Abu-Serie, Mohamed Teleb, Alexander Dömling, Assem Baraka. Molecular hybridization design and synthesis of novel spirooxindole-based MDM2 inhibitors endowed with BCL2 signaling attenuation; a step towards the next generation p53 activators. Bioorganic chemistry. vol 117. 2021-11-23. PMID:34794098. |
combination studies disclosed that concomitant inhibition of mdm2 and bcl2 functions can sensitize the tumor cells and synergistically induce apoptosis. |
2021-11-23 |
2023-08-13 |
Not clear |
| Gehad Lotfy, Yasmine M Abdel Aziz, Mohamed M Said, El Sayed H El Ashry, El Sayed H El Tamany, Marwa M Abu-Serie, Mohamed Teleb, Alexander Dömling, Assem Baraka. Molecular hybridization design and synthesis of novel spirooxindole-based MDM2 inhibitors endowed with BCL2 signaling attenuation; a step towards the next generation p53 activators. Bioorganic chemistry. vol 117. 2021-11-23. PMID:34794098. |
the nci-selected derivatives were screened for cytotoxic activities against normal fibroblasts, mda-mb 231, hepg-2, and caco-2 cells via mtt assay, subjected to mechanistic apoptosis studies for assessment of p53, bcl2, p21, and caspase 3/7 status, then evaluated for potential mdm2 inhibition utilizing mst assay. |
2021-11-23 |
2023-08-13 |
Not clear |
| Vikas A Gupta, Benjamin G Barwick, Shannon M Matulis, Ryosuke Shirasaki, David L Jaye, Jonathan J Keats, Benjamin Oberlton, Nisha S Joseph, Craig C Hofmeister, Leonard T Heffner, Madhav V Dhodapkar, Ajay K Nooka, Sagar Lonial, Constantine S Mitsiades, Jonathan L Kaufman, Lawrence H Bois. Venetoclax sensitivity in multiple myeloma is associated with B-cell gene expression. Blood. vol 137. issue 26. 2021-11-22. PMID:33649772. |
venetoclax is a highly potent, selective bcl2 inhibitor capable of inducing apoptosis in cells dependent on bcl2 for survival. |
2021-11-22 |
2023-08-13 |
Not clear |
| Gui Yang, Jiang-Qi Liu, Li-Hua Mo, Xiang-Qian Luo, Jianxiang Li, Zhi-Qiang Liu, Da-Bo Liu, Zhi-Gang Liu, Ping-Chang Yang, Jian-Bo Sh. Bcl2 like protine-12 (Bcl2L12) facilitates experimental airway allergic inflammation by inducing autocrine eotaxin in eosinophils. Immunology letters. vol 228. 2021-11-18. PMID:33132183. |
bcl2 like protein-12 (bcl2l12) is an apoptosis inhibitor and an immune regulator. |
2021-11-18 |
2023-08-13 |
Not clear |
| Fu Hua, Chang-Hua Li, Xiao-Gang Chen, Xiao-Ping Li. [Retracted] Daidzein exerts anticancer activity towards SKOV3 human ovarian cancer cells by inducing apoptosis and cell cycle arrest, and inhibiting the Raf/MEK/ERK cascade. International journal of molecular medicine. vol 47. issue 6. 2021-11-18. PMID:33846770. |
furthermore, cellular images featured in fig. 2a and b of the above paper appeared in fig. 2 of the following paper, albeit the data were presented in a different field of view: yu l, zhou g‑q and li d‑c: mir‑136 triggers apoptosis in human gastric cancer cells by targeting aeg‑1 and bcl2. |
2021-11-18 |
2023-08-13 |
human |
| Yajie Lu, Min Zhang, Qinjun Wei, Zhibin Chen, Guangqian Xing, Jun Yao, Xin Ca. Disruption of Gprasp2 down-regulates Hedgehog signaling and leads to apoptosis in auditory cells. Biochemical and biophysical research communications. vol 574. 2021-11-18. PMID:34418635. |
the differential expression of apoptosis molecules (bcl2, bax, caspase-3/cleaved-caspase-3) indicated that gprasp2-ko induced apoptosis in hei-oc1 cells. |
2021-11-18 |
2023-08-13 |
mouse |