| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M S Araujo, M D Guastali, F Paulini, A N Silva, M H Tsunemi, P K Fontes, A C S Castilho, F C Landim-Alvareng. Molecular and cellular effects of insulin-like growth factor-1 and LongR3-IGF-1 on in vitro maturation of bovine oocytes: comparative study. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. vol 55. 2021-10-12. PMID:33038561. |
addition effects of insulin-like growth factor-1 (igf-1) and its synthetic analogue insulin-like growth factor-1 recombinant-3 (longr3-igf-1) after in vitro maturation (ivm) of cattle cumulus-oocyte complexes (cocs) were compared and evaluated on meiotic progression, apoptosis and profile genes of oocyte competence (gdf9, bmp15, bax, bcl2, oosp1, igfbp2, igbfp4 and igfbp5), and their respective cumulus cells (areg, egfr, fshr, cox2, bax, bcl2, igfbp2, igfbp4 and igfbp5). |
2021-10-12 |
2023-08-13 |
cattle |
| Ping Zhong, Jin Liu, Hong Li, Senbin Lin, Lingfeng Zeng, Lingfeng Luo, Minxia Wu, Wenchang Zhan. MicroRNA-204-5p regulates apoptosis by targeting Bcl2 in rat ovarian granulosa cells exposed to cadmium†. Biology of reproduction. vol 103. issue 3. 2021-10-11. PMID:32500147. |
microrna-204-5p regulates apoptosis by targeting bcl2 in rat ovarian granulosa cells exposed to cadmium†. |
2021-10-11 |
2023-08-13 |
rat |
| Ping Zhong, Jin Liu, Hong Li, Senbin Lin, Lingfeng Zeng, Lingfeng Luo, Minxia Wu, Wenchang Zhan. MicroRNA-204-5p regulates apoptosis by targeting Bcl2 in rat ovarian granulosa cells exposed to cadmium†. Biology of reproduction. vol 103. issue 3. 2021-10-11. PMID:32500147. |
in addition, cd promoted apoptosis by decreasing the mrna and protein expression levels of inhibition of b-cell lymphoma 2 (bcl2). |
2021-10-11 |
2023-08-13 |
rat |
| Sandhya Yadav, Deepak Pant, Atul Samaiya, Neetu Kalra, Sanjay Gupta, Sanjeev Shukl. ERK1/2-EGR1-SRSF10 Axis Mediated Alternative Splicing Plays a Critical Role in Head and Neck Cancer. Frontiers in cell and developmental biology. vol 9. 2021-10-08. PMID:34616729. |
we observed that srsf10 plays a crucial role in hnc tumorigenesis by affecting the pro-death, pro-survical splice variants of bcl2l1 (bcl2 like 1: bclx: apoptosis regulator) and the two splice variants of pkm (pyruvate kinase m), pkm1 normal isoform to pkm2 cancer-specific isoform. |
2021-10-08 |
2023-08-13 |
Not clear |
| Vicente Fresquet, Maria J Garcia-Barchino, Marta Larrayoz, Jon Celay, Carmen Vicente, Marta Fernandez-Galilea, Maria J Larrayoz, Maria J Calasanz, Carlos Panizo, Alexandra Junza, Jiahuai Han, Celia Prior, Puri Fortes, Ruben Pio, Julen Oyarzabal, Alvaro Martinez-Baztan, Bruno Paiva, Maria J Moreno-Aliaga, Maria D Odero, Xabier Agirre, Oscar Yanes, Felipe Prosper, Jose A Martinez-Climen. Endogenous Retroelement Activation by Epigenetic Therapy Reverses the Warburg Effect and Elicits Mitochondrial-Mediated Cancer Cell Death. Cancer discovery. vol 11. issue 5. 2021-10-07. PMID:33355179. |
to maintain atp generation, hyperactive mitochondrial membrane blocks intrinsic apoptosis by increasing bcl2 dependency. |
2021-10-07 |
2023-08-13 |
Not clear |
| Praveen Kumar Reddy Nagireddy, Dinesh Kumar, Vamsi Krishna Kommalapati, Ravi Kumar Pedapati, Venkateswarlu Kojja, Anjana Devi Tangutur, Srinivas Kantevar. 9-Ethynyl noscapine induces G2/M arrest and apoptosis by disrupting tubulin polymerization in cervical cancer. Drug development research. 2021-10-06. PMID:34612529. |
we also observed that 9-ethynyl noscapine (5) treatment leads to disruption in tubulin polymerization and induction of apoptosis by decreasing expression of bcl2, pro-caspase 3, and activation of cytochrome c. taken together, our results indicate that 9-ethynyl noscapine (5) effectively supresses the growth of cervical cancer cells (hela) by disrupting tubulin polymerization, cell cycle progression leading to apoptosis. |
2021-10-06 |
2023-08-13 |
human |
| Liang Wei, Cheng Yang, Guangxue Wang, Keqin Li, Yanfei Zhang, Hongxin Guan, Zhiyang Sun, Chunlong Zhon. Interleukin Enhancer Binding Factor 2 Regulates Cell Viability and Apoptosis of Human Brain Vascular Smooth Muscle Cells. Journal of molecular neuroscience : MN. vol 71. issue 2. 2021-10-05. PMID:32748330. |
rt-qpcr results showed that ilf2 knock-down downregulated the expression levels of bcl2 apoptosis regulator (bcl2), transcriptional regulator myc-like (c-myc), and caspase 1 (ice) whereas upregulated the expression levels of cd95, p21, p53, and interleukin-13 (il-13). |
2021-10-05 |
2023-08-13 |
human |
| Rui Liang, Mingo M H Yung, Fangfang He, Peili Jiao, Karen K L Chan, Hextan Y S Ngan, David W Cha. The Stress-Inducible BCL2A1 Is Required for Ovarian Cancer Metastatic Progression in the Peritoneal Microenvironment. Cancers. vol 13. issue 18. 2021-10-01. PMID:34572804. |
under stress conditions, bcl2a1 accumulated and colocalized with mitochondria to suppress intrinsic cell apoptosis by interacting with the bh3-only subfamily bcl2 members hrk/bad/bid in ovarian cancer cells. |
2021-10-01 |
2023-08-13 |
Not clear |
| Jingang Sun, Cuicui Zhang, Zhigang Zhan. Atorvastatin attenuates cardiac hypertrophy through AMPK/miR-143-3p/Bcl2 axis. Archives of physiology and biochemistry. vol 127. issue 5. 2021-09-30. PMID:31353965. |
taken together, the data indicated that mir-143-3p aggravated cardiac hypertrophy by inducing cardiomyocytes apoptosis through inhibiting bcl2 expression. |
2021-09-30 |
2023-08-13 |
rat |
| Clémentine Sarkozy, Stacy S Hung, Elizabeth A Chavez, Gerben Duns, Katsuyoshi Takata, Lauren C Chong, Tomohiro Aoki, Aixiang Jiang, Tomoko Miyata-Takata, Adèle Telenius, Graham W Slack, Thierry Jo Molina, Susana Ben-Neriah, Pedro Farinha, Peggy Dartigues, Diane Damotte, Anja Mottok, Gilles A Salles, Rene-Olivier Casasnovas, Kerry J Savage, Camille Laurent, David W Scott, Alexandra Traverse-Glehen, Christian Steid. Mutational landscape of gray zone lymphoma. Blood. vol 137. issue 13. 2021-09-27. PMID:32961552. |
in contrast, gzl cases without thymic niche involvement (n = 18) had a significantly distinct pattern that was enriched in mutations related to apoptosis defects (tp53 [39%], bcl2 [28%], birc6 [22%]) and depleted in gna13, xpo1, or nf-κb signaling pathway mutations (tnfaip3, nfkbie, ikbkb, nfkbia). |
2021-09-27 |
2023-08-13 |
Not clear |
| Lili Tan, Limin Liu, Jian Yao, Chenghao Pia. miR-145-5p attenuates inflammatory response and apoptosis in myocardial ischemia-reperfusion injury by inhibiting (NADPH) oxidase homolog 1. Experimental animals. vol 70. issue 3. 2021-09-27. PMID:33658472. |
upregulation of mir-145-5p increased cell viability and reduced apoptosis accompanied by downregulation of bax, cleaved caspase-3, cleaved poly(adp-ribose) polymerase (parp) and upregulation of bcl2. |
2021-09-27 |
2023-08-13 |
rat |
| Soghra Mehri, Samira Barangi, Ehsan Zamiri, Gholamreza Karim. The protective effect of melatonin on benzo(a)pyrene-induced brain injury: role of apoptosis and autophagy pathways. Naunyn-Schmiedeberg's archives of pharmacology. vol 393. issue 12. 2021-09-24. PMID:32632567. |
western blot was conducted for the level of lc3 ii/i and beclin1, as autophagy markers, caspase3 and bcl2, as apoptosis proteins, and sirt1 in the brain. |
2021-09-24 |
2023-08-13 |
mouse |
| Manuel D Haschka, Gerlinde Karbon, Claudia Soratroi, Katelyn L O'Neill, Xu Luo, Andreas Villunge. MARCH5-dependent degradation of MCL1/NOXA complexes defines susceptibility to antimitotic drug treatment. Cell death and differentiation. vol 27. issue 8. 2021-09-23. PMID:32015503. |
degradation of the antiapoptotic bcl2 family member mcl-1 is considered to set the time until onset of apoptosis upon mta treatment. |
2021-09-23 |
2023-08-13 |
Not clear |
| Qingqing Li, Yansong Zhang, Yufang Yang, Songqing Huang, Xiaoqin Zou, Congying Wei, Taolin Liang, Xiaobin Zhon. Panax notoginseng saponins reduces the cisplatin-induced acute renal injury by increasing HIF-1α/BNIP3 to inhibit mitochondrial apoptosis pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 142. 2021-09-22. PMID:34385105. |
cell viability, mitochondrial function, cell apoptosis ratio and the expression of apoptosis-associated proteins (cyt c, bcl2, bax, caspases 3) were determined. |
2021-09-22 |
2023-08-13 |
human |
| Xuejiao An, Taotao Li, Nana Chen, Huihui Wang, Xia Wang, Youji M. PGAM1 regulates the glycolytic metabolism of SCs in tibetan sheep and its influence on the development of SCs. Gene. vol 804. 2021-09-22. PMID:34418471. |
the mrna expression of the cell proliferation-related genes pcna and bcl2 was significantly increased (p < 0.05), and the expression of cell apoptosis related genes bax and caspase3 was significantly decreased (p < 0.05). |
2021-09-22 |
2023-08-13 |
Not clear |
| Lisenn Lalier, Vincent Mignard, Marie-Pierre Joalland, Didier Lanoé, Pierre-François Cartron, Stéphen Manon, François M Vallett. TOM20-mediated transfer of Bcl2 from ER to MAM and mitochondria upon induction of apoptosis. Cell death & disease. vol 12. issue 2. 2021-09-21. PMID:33589622. |
tom20-mediated transfer of bcl2 from er to mam and mitochondria upon induction of apoptosis. |
2021-09-21 |
2023-08-13 |
Not clear |
| Lisenn Lalier, Vincent Mignard, Marie-Pierre Joalland, Didier Lanoé, Pierre-François Cartron, Stéphen Manon, François M Vallett. TOM20-mediated transfer of Bcl2 from ER to MAM and mitochondria upon induction of apoptosis. Cell death & disease. vol 12. issue 2. 2021-09-21. PMID:33589622. |
in u251 glioma cells, we found that bcl2 is localized mainly in the er and is translocated to mam and mitochondria upon induction of apoptosis; this mitochondrial transfer was not restricted to the demonstrator cell line, even if cell-specific modulations exist. |
2021-09-21 |
2023-08-13 |
Not clear |
| Lixia Feng, Xu Chen, Shenghua Zhang, Yunxia Chen, Yanling Y. Role of miR-139-5p in ectopic endometrial stromal cells and the underlying molecular mechanism. Experimental and therapeutic medicine. vol 22. issue 5. 2021-09-21. PMID:34539847. |
bbc3 (bcl2 binding component 3) is a known apoptosis inducer and it serves key roles in the regulation of cell behavior. |
2021-09-21 |
2023-08-13 |
Not clear |
| Ling Hu, Xi Pan, Jinyue Hu, Hong Zeng, Xueting Liu, Manli Jiang, Binyuan Jian. Proteasome inhibitors decrease paclitaxel‑induced cell death in nasopharyngeal carcinoma with the accumulation of CDK1/cyclin B1. International journal of molecular medicine. vol 48. issue 4. 2021-09-18. PMID:34435645. |
in addition, proteasome inhibitors combined with paclitaxel led to decreased mcl1 apoptosis regulator, bcl2 family member/caspase‑9/poly (adp‑ribose) polymerase apoptosis signaling triggered by cdk1/cyclin b1. |
2021-09-18 |
2023-08-13 |
Not clear |
| Lin Zhu, Jing Wu, Hong Li. Downregulation of HERC5 E3 ligase attenuates the ubiquitination of CtBP1 to inhibit apoptosis in colorectal cancer cells. Carcinogenesis. vol 42. issue 8. 2021-09-15. PMID:34147029. |
this transcriptional complex binds to the promoters of three proapoptotic genes, bcl2 associated x (bax), bcl2 interacting killer (bik) and p53upregulated modulator of apoptosis (puma), and inhibits their expression, thereby suppressing apoptotic signalling and promoting tumourigenesis. |
2021-09-15 |
2023-08-13 |
Not clear |