| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bo Lin, Youguang Gao, Zhiwang Li, Zhiming Zhang, Xianzhong Lin, Jinpeng Ga. Cannabidiol alleviates hemorrhagic shock-induced neural apoptosis in rats by inducing autophagy through activation of the PI3K/AKT pathway. Fundamental & clinical pharmacology. vol 34. issue 6. 2021-07-26. PMID:32215966. |
cbd treatment attenuated the neural apoptosis induced by hs, as reflected by restoring mitochondrial dysfunction, downregulation of bax, neuro-apoptosis ratio and nf-κb signaling activation, and upregulation of bcl2 in the cerebral cortex. |
2021-07-26 |
2023-08-13 |
rat |
| Jian Wei Xu, Ye Yan, Lei Wang, Dong Wu, Nai Kuan Ye, Shi Hong Chen, Feng L. Marine bioactive compound dieckol induces apoptosis and inhibits the growth of human pancreatic cancer cells PANC-1. Journal of biochemical and molecular toxicology. vol 35. issue 2. 2021-07-20. PMID:33051972. |
the induction of apoptosis was further evaluated with different staining techniques such as rhodamine 123 staining, acridine orange/ethidium bromide staining, dapi staining, propidium iodide staining and was confirmed by estimating the protein expression of apoptotic genes, bax and bcl2. |
2021-07-20 |
2023-08-13 |
human |
| Dingsheng Liu, Chunsheng Chen, Mingming Cui, Hong Zhan. miR-140-3p inhibits colorectal cancer progression and its liver metastasis by targeting BCL9 and BCL2. Cancer medicine. vol 10. issue 10. 2021-07-19. PMID:33838016. |
bcl2 knockdown increased apoptosis of mir-140-3p inhibitor-transfected hct 116 cells. |
2021-07-19 |
2023-08-13 |
mouse |
| Nabanita Mukherjee, Carol M Amato, Jenette Skees, Kaleb J Todd, Karoline A Lambert, William A Robinson, Robert Van Gulick, Ryan M Weight, Chiara R Dart, Richard P Tobin, Martin D McCarter, Mayumi Fujita, David A Norris, Yiqun G Shellma. Simultaneously Inhibiting BCL2 and MCL1 Is a Therapeutic Option for Patients with Advanced Melanoma. Cancers. vol 12. issue 8. 2021-07-16. PMID:32764384. |
our knockdown/knockout experiments suggest that several pro-apoptotic bcl2 family members, bcl2-like 11 (apoptosis facilitator) (bim), phorbol-12-myristate-13-acetate-induced protein 1 (noxa) or bid, play a role in the combination-induced effects. |
2021-07-16 |
2023-08-13 |
Not clear |
| Pin Lv, Yi-Fan Luo, Wen-Yi Zhou, Ben Liu, Zheng Zhou, Yong-Zhong Shi, Ren Huang, Chuang Peng, Zi-Li He, Jun Wang, Hong-Hui Zhang, Sheng-Dan Ni. miR-373 inhibits autophagy and further promotes apoptosis of cholangiocarcinoma cells by targeting ULK1. The Kaohsiung journal of medical sciences. vol 36. issue 6. 2021-07-15. PMID:32125086. |
overexpression of mir-373 reduced proliferation, enhanced apoptosis, and raised expression levels of pro-apoptosis proteins including bcl2 associated x (bax), caspase-3, and caspase-9. |
2021-07-15 |
2023-08-13 |
human |
| Anna Yu Korshunova, Mikhail L Blagonravov, Ekaterina V Neborak, Sergey P Syatkin, Anastasia P Sklifasovskaya, Said M Semyatov, Enzo Agostinell. BCL2‑regulated apoptotic process in myocardial ischemia‑reperfusion injury (Review). International journal of molecular medicine. vol 47. issue 1. 2021-07-15. PMID:33155658. |
there are several signaling pathways and compounds regulating bcl2, including pi3k/akt and mek1/erk1/2, jak2/stat3, endothelial nitric oxide synthase, pten, cardiac ankyrin repeat protein and microrna, which can serve as targets for modern methods of cardioprotective therapy inhibiting intrinsic apoptosis and saving viable cardiomyocytes after mi/ri. |
2021-07-15 |
2023-08-13 |
Not clear |
| Mengmeng Yu, Yang Wang, Ping Li, Meng Li, Xuejun Ga. Taurine attenuates gossypol-induced apoptosis of C2C12 mouse myoblasts via the GPR87-AMPK/AKT signaling. Amino acids. vol 52. issue 9. 2021-07-12. PMID:32918616. |
gossypol significantly induced apoptosis, decreased bcl2 expression, and increased the protein levels of bax and the cleaved caspase 3. |
2021-07-12 |
2023-08-13 |
mouse |
| Chuang Du, Yan Wang, Yingying Zhang, Jianhua Zhang, Linfeng Zhang, Jingruo L. LncRNA DLX6-AS1 Contributes to Epithelial-Mesenchymal Transition and Cisplatin Resistance in Triple-negative Breast Cancer via Modulating Mir-199b-5p/Paxillin Axis. Cell transplantation. vol 29. 2021-07-09. PMID:32686982. |
knock down of dlx6-as1 inhibited cell proliferation, epithelial-mesenchymal transition (emt), decreased expression levels of bcl2 apoptosis regulator (bcl-2), snail family transcriptional repressor 1 (snail) as well as n-cadherin and decreased expression levels of cleaved caspase-3, γ-catenin as well as e-cadherin, while up regulation of dlx6-as1 had the opposite effect. |
2021-07-09 |
2023-08-13 |
mouse |
| Fatemeh Ghorbani, Seyed-Morteza Javadirad, Farzane Amirmahani, Zahra Fatehi, Manoochehr Tavassol. Associations of BCL2 CA-Repeat Polymorphism and Breast Cancer Susceptibility in Isfahan Province of Iran. Biochemical genetics. vol 59. issue 2. 2021-07-06. PMID:33151448. |
bcl2 apoptosis regulator (bcl2) is a cause of tumorigenesis whose ca-repeat promoter polymorphisms has inconsistent association with various types of cancers. |
2021-07-06 |
2023-08-13 |
Not clear |
| Wei Liang, Junfeng Shi, Haiyan Xia, Xiaowei We. A Novel Ruthenium-Fluvastatin Complex Downregulates SNCG Expression to Modulate Breast Carcinoma Cell Proliferation and Apoptosis via Activating the PI3K/Akt/mTOR/VEGF/MMP9 Pathway. Oxidative medicine and cellular longevity. vol 2021. 2021-07-06. PMID:34221232. |
in addition, the complex was able to modify p53 expressions to interfere with apoptosis in the carcinoma of the breast, stimulated by the intrinsic apoptotic path assisted by bcl2 and bax in vivo, yet at the same point, controlling the pi3k/akt/mtor/vegf pathway, as obtained from western blotting, correlates with the mmp9-regulated tumor mechanisms. |
2021-07-06 |
2023-08-13 |
Not clear |
| Atousa Khalatbari, Mehdi Mahdavi, Fahimeh Jafarnezhad, Sanaz Afraei, Farzaneh Tofighi Zavareh, Zahra Aghazadeh, Afshin Ghaderi, Abbas Mirshafie. Efficacy of β-D-Mannuronic Acid [M2000] on the Pro-Apoptotic Process and Inflammatory-Related Molecules NFκB, IL-8 and Cd49d using Healthy Donor PBMC. Current drug discovery technologies. vol 17. issue 2. 2021-07-05. PMID:30417790. |
this investigation evaluates the pro-apoptotic and anti-inflammatory effects of β-d-mannuronic acid [m2000] compared to diclofenac, based on gene expression involved in apoptosis and inflammation process [including bcl2, nfκb, il-8 and cd49d] in peripheral blood mononuclear cells [pbmcs] of healthy donors under exvivo conditions. |
2021-07-05 |
2023-08-13 |
Not clear |
| Sangah Lee, Jiyae Jung, Yu-Jin Lee, Seon-Kyu Kim, Jung-Ae Kim, Bo-Kyung Kim, Kyung Chan Park, Byoung-Mog Kwon, Dong Cho Ha. Targeting HSF1 as a Therapeutic Strategy for Multiple Mechanisms of EGFR Inhibitor Resistance in EGFR Mutant Non-Small-Cell Lung Cancer. Cancers. vol 13. issue 12. 2021-07-05. PMID:34203709. |
hsf1 inhibition by using hsf1 shrnas or kribb11 decreased the expression of hsf1 downstream proteins, such as hsp70 and hsp27, and also decreased the expression of hsp90/hsp70/bag3 client proteins, such as bcl2, mcl1, egfr, met, and axl, causing apoptosis of egfr-tki-resistant cancer cells. |
2021-07-05 |
2023-08-13 |
Not clear |
| Subramanyam Dasari, Taruni Pandhiri, Tommaso Grassi, Daniel W Visscher, Francesco Multinu, Komal Agarwal, Andrea Mariani, Viji Shridhar, Anirban K Mitr. Signals from the Metastatic Niche Regulate Early and Advanced Ovarian Cancer Metastasis through miR-4454 Downregulation. Molecular cancer research : MCR. vol 18. issue 8. 2021-07-02. PMID:32350057. |
its mechanism of action was through the upregulation of its targets, secreted protein acidic and cysteine rich (sparc) and bcl2 associated athanogene 5 (bag5), which activated focal adhesion kinase (fak) signaling, promoted mutant p53 gain of function by its stabilization, and inhibited apoptosis. |
2021-07-02 |
2023-08-13 |
Not clear |
| Thomas R Holmes, Jenan Al Matouq, Matti Holmes, Natasha Sioda, Justin C Rudd, Celia Bloom, Lauren Nicola, Nicholas Y Palermo, Justin G Madson, Sándor Lovas, Laura A Hanse. Targeting 14-3-3ε activates apoptotic signaling to prevent cutaneous squamous cell carcinoma. Carcinogenesis. vol 42. issue 2. 2021-06-25. PMID:32816038. |
14-3-3ε suppressed apoptosis through activation of akt, leading to inhibition of bcl2 associated agonist of cell death and upregulation of survivin. |
2021-06-25 |
2023-08-13 |
human |
| Arvind Ramanathan, Akash Parvatikar, Srinivas C Chennubhotla, Yang Mei, Sangita C Sinh. Transient Unfolding and Long-Range Interactions in Viral BCL2 M11 Enable Binding to the BECN1 BH3 Domain. Biomolecules. vol 10. issue 9. 2021-06-24. PMID:32932757. |
viral bcl2 proteins (vbcl2s) help to sustain chronic infection of host proteins to inhibit apoptosis and autophagy. |
2021-06-24 |
2023-08-13 |
Not clear |
| Raed S Ismail, Mohammed S El-Awady, Memy H Hassa. Pantoprazole abrogated cisplatin-induced nephrotoxicity in mice via suppression of inflammation, apoptosis, and oxidative stress. Naunyn-Schmiedeberg's archives of pharmacology. vol 393. issue 7. 2021-06-21. PMID:31950223. |
furthermore, pantoprazole mostly normalized cisplatin-induced distortion of renal levels of inflammatory cytokines (tumor necrosis factor-alpha, interleukin-6, interleukin-10) and renal content of apoptosis regulating protein expressions (bax, bcl2, and active caspase 3). |
2021-06-21 |
2023-08-13 |
mouse |
| Raed S Ismail, Mohammed S El-Awady, Memy H Hassa. Pantoprazole abrogated cisplatin-induced nephrotoxicity in mice via suppression of inflammation, apoptosis, and oxidative stress. Naunyn-Schmiedeberg's archives of pharmacology. vol 393. issue 7. 2021-06-21. PMID:31950223. |
the protective mechanism of pantoprazole could be through diminution of cisplatin-induced inflammation, oxidative stress, and their subsequent apoptotic renal cell death via abatement of apoptosis regulating protein expressions (bax, bcl2, and active caspase3). |
2021-06-21 |
2023-08-13 |
mouse |
| Larissa Berloffa Belardin, Maria Beatriz Ribeiro de Andrade, Paula Intasqui, Deborah Montagnini Spaine, Ricardo Pimenta Bertolla, Mariana Pereira Antoniass. Restoration of the apoptosis pathways' proteins levels after orchiectomy in testicular tumour patients. Andrologia. vol 52. issue 11. 2021-06-21. PMID:33070399. |
comparing pre- and post-orchiectomy groups, just the apoptosis pathways' proteins presented different levels, in which bad was lower and bcl2, akt, caspase-9, p53 and caspase-8 were higher after orchiectomy. |
2021-06-21 |
2023-08-13 |
Not clear |
| Larissa Berloffa Belardin, Maria Beatriz Ribeiro de Andrade, Paula Intasqui, Deborah Montagnini Spaine, Ricardo Pimenta Bertolla, Mariana Pereira Antoniass. Restoration of the apoptosis pathways' proteins levels after orchiectomy in testicular tumour patients. Andrologia. vol 52. issue 11. 2021-06-21. PMID:33070399. |
regarding the apoptosis pathway, lower levels of jnk, bcl2, akt, caspase-9, p53 and caspase-8 and higher levels of bad were observed before orchiectomy. |
2021-06-21 |
2023-08-13 |
Not clear |
| Vahid Mohammadi, Seyed Davood Sharifi, Mohsen Sharafi, Abdollah Mohammadi-Sangcheshmeh, Elham Abedheydari, AliReza Alizade. Dietary L-carnitine affects the expression of genes involved in apoptosis and fatty acid metabolism in rooster testes. Andrologia. vol 52. issue 11. 2021-06-21. PMID:33125782. |
the results demonstrate the beneficial effects of lc supplementation in suppression of the bak/bcl2 ratio by altering bak and bcl2 mrna abundance and, ultimately, prevention of apoptosis. |
2021-06-21 |
2023-08-13 |
chicken |