| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pedro Morán, Julieta Manrique, Sandra Pérez, Florencia Romeo, Anselmo Odeón, Leandro Jones, Andrea Vern. Analysis of the anti-apoptotic v-Bcl2 and v-Flip genes and effect on in vitro programmed cell death of Argentinean isolates of bovine gammaherpesvirus 4 (BoHV-4). Microbial pathogenesis. vol 144. 2021-04-14. PMID:32224211. |
the objective of this work was to analyze whether variations in v-flip and v- bcl2 of six phylogenetically divergent argentinean isolates of bohv-4 can influence the capacity of these strains to induce apoptosis in cell cultures. |
2021-04-14 |
2023-08-13 |
cattle |
| Hanan Saleh, Haidan M El-Shorbag. Chitosan protects liver against ischemia-reperfusion injury via regulating Bcl-2/Bax, TNF-α and TGF-β expression. International journal of biological macromolecules. vol 164. 2021-04-08. PMID:32735924. |
marked reduction of apoptosis has been indicated by the elevation in bcl2, and decreasing in bax, caspace-3 and cytochrome-c expression levels, which furthermore confirmed by dna fragmentation assay. |
2021-04-08 |
2023-08-13 |
cat |
| Carolane Seiller, Sophie Maiga, Cyrille Touzeau, Céline Bellanger, Charlotte Kervoëlen, Géraldine Descamps, Laurent Maillet, Philippe Moreau, Catherine Pellat-Deceunynck, Patricia Gomez-Bougie, Martine Amio. Dual targeting of BCL2 and MCL1 rescues myeloma cells resistant to BCL2 and MCL1 inhibitors associated with the formation of BAX/BAK hetero-complexes. Cell death & disease. vol 11. issue 5. 2021-04-07. PMID:32371863. |
multiple myeloma is a plasma cell malignancy that escapes from apoptosis by heterogeneously over-expressing anti-apoptotic bcl2 proteins. |
2021-04-07 |
2023-08-13 |
Not clear |
| Bingxian Liu, Qiwen Zeng, Hanming Chen, Jianzhao Liao, Yuman Bai, Qingyue Han, Na Qiao, Shuzhou Wang, Khalid Mehmood, Riaz Hussain, Bhutto Zohaib Ahmed, Zhaoxin Tang, Hui Zhang, Ying L. The hepatotoxicity of altrazine exposure in mice involves the intestinal microbiota. Chemosphere. vol 272. 2021-04-06. PMID:33485040. |
moreover, results also revealed that atr induced apoptosis via disruption of apoptotic (bax, bcl2, and casp3) and autophagy (lc3/map1lc3a, beclin 1/becn1 and p62/sqstm1) genes. |
2021-04-06 |
2023-08-13 |
mouse |
| Hongmei Tang, Qi Chen, Wenyuan Yu, Tianlan Zha. MiR-4328 inhibits proliferation, metastasis and induces apoptosis in keloid fibroblasts by targeting BCL2 expression. Open life sciences. vol 15. issue 1. 2021-04-06. PMID:33817252. |
mir-4328 inhibits proliferation, metastasis and induces apoptosis in keloid fibroblasts by targeting bcl2 expression. |
2021-04-06 |
2023-08-13 |
Not clear |
| Johanna Strobl, Ram Vinay Pandey, Thomas Krausgruber, Lisa Kleissl, Bärbel Reininger, Merima Herac, Nadine Bayer, Christoph Krall, Philipp Wohlfarth, Margit Mitterbauer, Peter Kalhs, Werner Rabitsch, Christoph Bock, Georg Hopfinger, Georg Star. Anti-Apoptotic Molecule BCL2 Is a Therapeutic Target in Steroid-Refractory Graft-Versus-Host Disease. The Journal of investigative dermatology. vol 140. issue 11. 2021-04-02. PMID:32247860. |
inhibition of bcl2 increased the cd4 to cd8 ratio in allogeneic t cells in vitro and induced apoptosis of t cells from patients with steroid-pretreated chronic gvhd ex vivo. |
2021-04-02 |
2023-08-13 |
Not clear |
| Debalina Bhattacharya, Moumita Dutta, Mainak Mukhopadhyay, Maitree Bhattacharyya, Subhankar Chowdhury, Parimal Karmaka. The protective role of metformin in autophagic status in peripheral blood mononuclear cells of type 2 diabetic patients. Cell biology international. vol 44. issue 8. 2021-03-29. PMID:32237184. |
also, induction of autophagy by tunicamycin resulted in apoptosis in diabetic pbmcs as observed by caspase-3 cleavage and reduced expression of bcl2. |
2021-03-29 |
2023-08-13 |
human |
| G Rizzoto, J C P Ferreira, V M Codognoto, K C Oliveira, H D Mogollón García, A G R Pupulim, F J Teixeira-Neto, A Castilho, S G Nunes, J C Thundathil, J P Kasteli. Testicular hyperthermia reduces testosterone concentrations and alters gene expression in testes of Nelore bulls. Theriogenology. vol 152. 2021-03-29. PMID:32380276. |
huge increases in hsp70 conferred protection again apoptosis and cell destruction, whereas reduced bcl2 promoted apoptosis. |
2021-03-29 |
2023-08-13 |
Not clear |
| Meng Jin, Xiuna Ji, Rostyslav Stoika, Kechun Liu, Lizhen Wang, Yang Son. Synthesis of a novel fluorescent berberine derivative convenient for its subcellular localization study. Bioorganic chemistry. vol 101. 2021-03-29. PMID:32629278. |
it was shown that the synthesized fluorescent derivative could penetrate into human breast carcinoma mcf7 cells, and then induced apoptosis detected by the western blot analysis as changed expression of apoptosis-related proteins, including bax, bcl2, and cyto c released from mitochondria, cleaved caspase 9, cleaved parp, pro-caspase 3, and cleaved caspase 3. |
2021-03-29 |
2023-08-13 |
human |
| Grant R Campbell, Rachel K To, Gang Zhang, Stephen A Specto. SMAC mimetics induce autophagy-dependent apoptosis of HIV-1-infected macrophages. Cell death & disease. vol 11. issue 7. 2021-03-25. PMID:32719312. |
in contrast to cd4+ t cells, hiv-mφ are resistant to the cytopathic effects of acute hiv infection and have increased expression of cell survival factors, including x-linked inhibitor of apoptosis (xiap), baculoviral iap repeat containing (birc) 2/ciap1, beclin-1, bcl2, bcl-xl, triggering receptor expressed on myeloid cells 1, mitofusin (mfn) 1, and mfn2. |
2021-03-25 |
2023-08-13 |
human |
| Chengzhu Liao, Yuming Jin, Yuchao Li, Sie Chin Tjon. Interactions of Zinc Oxide Nanostructures with Mammalian Cells: Cytotoxicity and Photocatalytic Toxicity. International journal of molecular sciences. vol 21. issue 17. 2021-03-25. PMID:32878253. |
these ros-mediated responses induce caspase-dependent apoptosis via the activation of b-cell lymphoma 2 (bcl2), bcl2-associated x protein (bax), ccaat/enhancer-binding protein homologous protein (chop), and phosphoprotein p53 gene expressions. |
2021-03-25 |
2023-08-13 |
mouse |
| Andrew W Robert. Therapeutic development and current uses of BCL-2 inhibition. Hematology. American Society of Hematology. Education Program. vol 2020. issue 1. 2021-03-24. PMID:33275682. |
b-cell lymphoma 2 (bcl2) is a key protein regulator of apoptosis. |
2021-03-24 |
2023-08-13 |
Not clear |
| Thalita Alves Zanetti, Bruna Isabela Biazi, Giuliana Castello Coatti, Adrivanio Baranoski, Lilian Areal Marques, Amanda Cristina Corveloni, Mario Sergio Mantovan. Dimethoxycurcumin reduces proliferation and induces apoptosis in renal tumor cells more efficiently than demethoxycurcumin and curcumin. Chemico-biological interactions. vol 338. 2021-03-24. PMID:33582110. |
this dysregulation induced cell death through a caspase-independent pathway but was mediated by decrease in mtor and bcl2 mrna expression, suggesting that apoptosis occurred by autophagy. |
2021-03-24 |
2023-08-13 |
human |
| Suxia Zheng, Maolei Gong, Jing Che. Extracellular vesicles enriched with miR-150 released by macrophages regulates the TP53-IGF-1 axis to alleviate myocardial infarction. American journal of physiology. Heart and circulatory physiology. vol 320. issue 3. 2021-03-22. PMID:33164579. |
furthermore, increased expression of ev-derived mir-150 prevented cardiomyocyte apoptosis in vitro, as evidenced by downregulated bax and cleaved-caspase 3 and upregulated bcl2 and alleviated mi in vivo. |
2021-03-22 |
2023-08-13 |
mouse |
| Yang Li, Feifei Ma, Zengqiang Li, Yige Yu, Haoni Yan, Anam Tahir, Wenwen Zheng, Xiaoheng Li, Tongliang Huang, Ren-Shan G. Exposure to 4-bromodiphenyl ether during pregnancy blocks testis development in male rat fetuses. Toxicology letters. vol 342. 2021-03-22. PMID:33582287. |
in utero exposure to bde3 can promote autophagy and apoptosis of fetal leydig cells via increasing the levels of beclin1, lc3-ii, bax, and by decreasing the levels of p62 and bcl2. |
2021-03-22 |
2023-08-13 |
rat |
| Qifeng Han, Todd Bradley, Wilton B Williams, Derek W Cain, David C Montefiori, Kevin O Saunders, Robert J Parks, Regina W Edwards, Guido Ferrari, Olaf Mueller, Xiaoying Shen, Kevin J Wiehe, Steven Reed, Christopher B Fox, Wes Rountree, Nathan A Vandergrift, Yunfei Wang, Laura L Sutherland, Sampa Santra, M Anthony Moody, Sallie R Permar, Georgia D Tomaras, Mark G Lewis, Koen K A Van Rompay, Barton F Hayne. Neonatal Rhesus Macaques Have Distinct Immune Cell Transcriptional Profiles following HIV Envelope Immunization. Cell reports. vol 30. issue 5. 2021-03-16. PMID:32023469. |
transcriptome analyses of neonatal versus adult immune cells after env vaccination reveal that neonatal macaques have higher levels of the apoptosis regulator bcl2 in t cells and lower levels of the immunosuppressive interleukin-10 (il-10) receptor alpha (il10ra) mrna transcripts in t cells, b cells, natural killer (nk) cells, and monocytes. |
2021-03-16 |
2023-08-13 |
Not clear |
| Patrycja Kurowska, Ewa Mlyczyńska, Joelle Dupont, Agnieszka Ra. Novel Insights on the Corpus Luteum Function: Role of Vaspin on Porcine Luteal Cell Angiogenesis, Proliferation and Apoptosis by Activation of GRP78 Receptor and MAP3/1 Kinase Pathways. International journal of molecular sciences. vol 21. issue 18. 2021-03-15. PMID:32957618. |
porcine luteal cells were incubated with vaspin (0.1-10 ng/ml) for 24 h to 72 h and then mrna and protein expression of angiogenesis: vascular endothelial growth factor (vegfa), fibroblast growth factor 2 (fgf2), angiopoietin 1 (angpt1), vegfa receptors (vegfr1, vegfr2), apoptosis: caspase 3, bcl-2-like protein 4 (bax), b-cell lymphoma (bcl2), and proliferation: proliferating cells nuclear antigen (pcna), cyclin a factors as well as secretion of vegfa, fgf2, angt1 were measured by real-time polymerase chain reaction (pcr), immunoblotting and enzyme-linked immunosorbent assay (elisa), respectively. |
2021-03-15 |
2023-08-13 |
Not clear |
| Pradip Kumar Jaiswara, Vishal Kumar Gupta, Pratishtha Sonker, Shiv Govind Rawat, Rajan Kumar Tiwari, Chandramani Pathak, Santosh Kumar, Ajay Kuma. Nimbolide induces cell death in T lymphoma cells: Implication of altered apoptosis and glucose metabolism. Environmental toxicology. vol 36. issue 4. 2021-03-11. PMID:33274819. |
nimbolide-induced apoptosis in t lymphoma cells by altering the level of reactive oxygen species, p53, bcl2, bax, and cytochrome c, with subsequent cleavage of caspase 3. |
2021-03-11 |
2023-08-13 |
Not clear |
| Anna Kleczka, Robert Kubina, Radosław Dzik, Krzysztof Jasik, Jerzy Stojko, Krzysztof Cholewa, Agata Kabała-Dzi. Caffeic Acid Phenethyl Ester (CAPE) Induced Apoptosis in Serous Ovarian Cancer OV7 Cells by Deregulation of BCL2/BAX Genes. Molecules (Basel, Switzerland). vol 25. issue 15. 2021-03-09. PMID:32752091. |
in ov7 cells cape induced apoptosis via dysregulation of bax/bcl2 balance, while activated proapoptotic bax gene expression level was 10 times higher than bcl2. |
2021-03-09 |
2023-08-13 |
Not clear |
| Xin Chen, Tailang Yin, Baozhen Zhang, Beini Sun, Jie Chen, Tianxia Xiao, Baobei Wang, Mengxia Li, Jing Yang, Xiujun Fa. Inhibitory effects of brusatol delivered using glycosaminoglycan‑placental chondroitin sulfate A‑modified nanoparticles on the proliferation, migration and invasion of cancer cells. International journal of molecular medicine. vol 46. issue 2. 2021-03-08. PMID:32626948. |
further studies demonstrated that the plcsa‑bnps promoted the apoptosis of cancer cells more effectively and inhibited their proliferation, invasion and migration, accompanied by downregulation of matrix metalloproteinase (mmp)‑2, mmp‑9 and b‑cell cll/lymphoma 2 (bcl2) levels, but upregulation of bcl2‑associated x protein bax and cleaved caspase‑3 levels. |
2021-03-08 |
2023-08-13 |
Not clear |