| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Arjun Sharma, Pravir Kumar, Rashmi K Ambast. Cancer Fighting SiRNA-RRM2 Loaded Nanorobots. Pharmaceutical nanotechnology. vol 8. issue 2. 2020-12-14. PMID:32003677. |
the knockdown of rrm2 leads to apoptosis via bcl2 in cancer. |
2020-12-14 |
2023-08-13 |
Not clear |
| Kinga Szymona, Ewa Dudzińska, Hanna Karakuła-Juchnowicz, Paulina Gil-Kulik, Piotr Chomik, Małgorzata Świstowska, Joanna Gałaszkiewicz, Janusz Kock. Analysis of the expression of BAX, BCL2, BIRC6, CASP3, CASP9 apoptosis genes during the first episode of schizophrenia. Psychiatria polska. vol 53. issue 6. 2020-12-10. PMID:32017818. |
analysis of the expression of bax, bcl2, birc6, casp3, casp9 apoptosis genes during the first episode of schizophrenia. |
2020-12-10 |
2023-08-13 |
Not clear |
| Kinga Szymona, Ewa Dudzińska, Hanna Karakuła-Juchnowicz, Paulina Gil-Kulik, Piotr Chomik, Małgorzata Świstowska, Joanna Gałaszkiewicz, Janusz Kock. Analysis of the expression of BAX, BCL2, BIRC6, CASP3, CASP9 apoptosis genes during the first episode of schizophrenia. Psychiatria polska. vol 53. issue 6. 2020-12-10. PMID:32017818. |
the aim of the study was the analysis of (1) the level of bax,bcl2,birc6,casp3, casp9 apoptosis genes expression in schizophrenic patients and in the control group, and (2) the relationships between the genes expression level and the morphological and biochemical parameters, as well as the severity of psychopathological symptoms. |
2020-12-10 |
2023-08-13 |
Not clear |
| Maria Jesús García-Murria, Gerard Duart, Brayan Grau, Elisabet Diaz-Beneitez, Dolores Rodríguez, Ismael Mingarro, Luis Martínez-Gi. Viral Bcl2s' transmembrane domain interact with host Bcl2 proteins to control cellular apoptosis. Nature communications. vol 11. issue 1. 2020-12-09. PMID:33247105. |
viral bcl2s' transmembrane domain interact with host bcl2 proteins to control cellular apoptosis. |
2020-12-09 |
2023-08-13 |
Not clear |
| Maria Jesús García-Murria, Gerard Duart, Brayan Grau, Elisabet Diaz-Beneitez, Dolores Rodríguez, Ismael Mingarro, Luis Martínez-Gi. Viral Bcl2s' transmembrane domain interact with host Bcl2 proteins to control cellular apoptosis. Nature communications. vol 11. issue 1. 2020-12-09. PMID:33247105. |
vbcl2s control apoptosis by interacting with host pro- and anti-apoptotic members of the bcl2 family. |
2020-12-09 |
2023-08-13 |
Not clear |
| Stefania Bottardi, Romain Guieze, Vincent Bourgoin, Nasser Fotouhi-Ardakani, Aurore Dougé, Anaïs Darracq, Yahia A Lakehal, Marc G Berger, Luigina Mollica, Jacques-Olivier Bay, James G Omichinski, Eric Milo. MNDA controls the expression of MCL-1 and BCL-2 in chronic lymphocytic leukemia cells. Experimental hematology. vol 88. 2020-12-08. PMID:32682001. |
we propose that this rapid dynamic tuning of rna levels, which leads to the destabilization of mcl1 and bcl2 transcripts, represents a post-transcriptional mechanism of apoptosis control in cll cells. |
2020-12-08 |
2023-08-13 |
human |
| Jacob T Jackson, Kristy O'Donnell, Amanda Light, Wilford Goh, Nicholas D Huntington, David M Tarlinton, Matthew P McCormac. Hhex regulates murine lymphoid progenitor survival independently of Stat5 and Cdkn2a. European journal of immunology. vol 50. issue 7. 2020-12-07. PMID:32090320. |
as loss of hhex causes apoptosis of lymphoid progenitors associated with impaired bcl2 expression and defective stat5b signaling, we tested the effects of rescuing these pathways using transgenic mice. |
2020-12-07 |
2023-08-13 |
mouse |
| Ling Chen, Qingxiang Hou, Li Feng, Ling Li Xin, Li M. Inhibitory and protective effect of obovatol against uterine fibroid (leiomyoma) cells. Pakistan journal of pharmaceutical sciences. vol 33. issue 1(Supplementary). 2020-12-04. PMID:32122859. |
in addition, apoptosis regulatory proteins like bcl2 and bax were substantially down and up-regulated respectively, by ob in a dose-dependent fashion. |
2020-12-04 |
2023-08-13 |
human |
| Baoyuan Jin, Hyehyun Kim, Jeong-Il Choi, Hong-Beom Bae, Seongtae Jeon. Avenanthramide C Prevents Neuronal Apoptosis via PI3K/Akt/GSK3β Signaling Pathway Following Middle Cerebral Artery Occlusion. Brain sciences. vol 10. issue 11. 2020-12-01. PMID:33233587. |
we evaluated the blood brain barrier (bbb) integrity (zo-1, ve-cadherin and occludin) and apoptosis (bax, bcl2, caspase3, cytochrome c, and poly adp ribose polymerase(parp)-1). |
2020-12-01 |
2023-08-13 |
mouse |
| Tianxu Zhang, Zhenguang Yan, Xin Zheng, Shuping Wang, Juntao Fan, Zhengtao Li. Effects of acute ammonia toxicity on oxidative stress, DNA damage and apoptosis in digestive gland and gill of Asian clam (Corbicula fluminea). Fish & shellfish immunology. vol 99. 2020-11-30. PMID:32092406. |
the results showed that ammonia poisoning could increase the activity of oxidative stress enzyme (sod and cat), inducing differentially expressed genes (dram2, gadd45, p53, bax, bcl2, casp8, casp9, casp3, hsp70 and hsp90) and different cytokines (il-1 beta, il-8, il-17 and tnf-alpha) of dna damage and apoptosis. |
2020-11-30 |
2023-08-13 |
cat |
| Victor S Lin, Zhuo-Fan Xu, David C S Huang, Rachel Thijsse. BH3 Mimetics for the Treatment of B-Cell Malignancies-Insights and Lessons from the Clinic. Cancers. vol 12. issue 11. 2020-11-29. PMID:33198338. |
the intrinsic pathway of apoptosis is tightly controlled by interactions amongst members of three distinct subgroups of the b-cell lymphoma 2 (bcl2) family of proteins. |
2020-11-29 |
2023-08-13 |
Not clear |
| Victor S Lin, Zhuo-Fan Xu, David C S Huang, Rachel Thijsse. BH3 Mimetics for the Treatment of B-Cell Malignancies-Insights and Lessons from the Clinic. Cancers. vol 12. issue 11. 2020-11-29. PMID:33198338. |
the pro-survival bcl2 proteins prevent apoptosis by keeping the pro-apoptotic effector proteins bcl2-associated x protein (bax) and bcl2 homologous antagonist/killer (bak) in check, while the bh3-only proteins initiate apoptosis by either neutralizing the pro-survival bcl2 proteins or directly activating the pro-apoptotic effector proteins. |
2020-11-29 |
2023-08-13 |
Not clear |
| Kaviyarasi Renu, Anusha Saravanan, Anushree Elangovan, Sineka Ramesh, Sivakumar Annamalai, Arunraj Namachivayam, Praveena Abel, Harishkumar Madhyastha, Radha Madhyastha, Masugi Maruyama, Vellingiri Balachandar, Abilash Valsala Gopalakrishna. An appraisal on molecular and biochemical signalling cascades during arsenic-induced hepatotoxicity. Life sciences. vol 260. 2020-11-27. PMID:32949585. |
along with that, arsenic activates caspases and bax, decreases bcl2 through mitochondrial dysfunction, and induces apoptosis regulatory mechanism. |
2020-11-27 |
2023-08-13 |
Not clear |
| Jongbeom Song, Sang-Suk Lee, Sabina Lim, Sujung Ye. Mechanism of the neuroprotective effect of injecting brain cells on ST36 in an animal model of Parkinson's disease. Neuroscience letters. vol 717. 2020-11-24. PMID:31857129. |
apoptosis factors cytochrome c and bcl2 associated x, apoptosis regulator (bax) levels were decreased and b-cell cll/lymphoma 2 (bcl2) levels were increased. |
2020-11-24 |
2023-08-13 |
mouse |
| Zhan Gao, Qiang Gao, Xiaodong L. MicroRNA-668-3p Protects Against Oxygen-Glucose Deprivation in a Rat H9c2 Cardiomyocyte Model of Ischemia-Reperfusion Injury by Targeting the Stromal Cell-Derived Factor-1 (SDF-1)/CXCR4 Signaling Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2020-11-24. PMID:31997826. |
protein and mrna levels of sdf-1, cxcr4, bcl2, bax, cleaved caspase-3, endothelial nitric oxide synthase (enos), and phosphorylated endothelial nitric oxide synthase (p-enos) were analyzed by western blot and quantitative reverse transcription-polymerase chain reaction (rt-qpcr), and apoptosis were assessed by flow cytometry. |
2020-11-24 |
2023-08-13 |
rat |
| Kiruthika Sundarraj, Azhwar Raghunath, Lakshmikanthan Panneerselvam, Ekambaram Peruma. Fisetin, a phytopolyphenol, targets apoptotic and necroptotic cell death in HepG2 cells. BioFactors (Oxford, England). vol 46. issue 1. 2020-11-19. PMID:31634424. |
fisetin reduced the expression of bcl2, and elevated levels of bax, caspase-3, and parp and thus induced apoptosis in hepg2 cells. |
2020-11-19 |
2023-08-13 |
human |
| Vishal Kumar Gupta, Pradip Kumar Jaiswara, Pratishtha Sonker, Shiv Govind Rawat, Rajan Kumar Tiwari, Ajay Kuma. Lysophosphatidic acid promotes survival of T lymphoma cells by altering apoptosis and glucose metabolism. Apoptosis : an international journal on programmed cell death. vol 25. issue 1-2. 2020-11-19. PMID:31867678. |
observations of this investigation suggest that lpa supports survival of t lymphoma cells via altering apoptosis and glucose metabolism through changing the level of reactive species, namely nitric oxide and reactive oxygen species along with expression of various survival and glucose metabolism regulatory molecules, including hypoxia-inducible factor 1-alpha, p53, bcl2, and glucose transporter 3, hexokinase ii, pyruvate kinase muscle isozyme 2, monocarboxylate transporter 1, pyruvate dehydrogenase kinase 1. |
2020-11-19 |
2023-08-13 |
Not clear |
| Lang Zhao, Kang Fu, Xiaoxing Li, Rui Zhang, Wenjun Wang, Feng Xu, Xiaoping Ji, Yuguo Chen, Chuanbao L. Aldehyde dehydrogenase 2 protects cardiomyocytes against lipotoxicity via the AKT/glycogen synthase kinase 3 beta pathways. Biochemical and biophysical research communications. vol 525. issue 2. 2020-11-09. PMID:32089266. |
in addition, aldehyde dehydrogenase 2 overexpression inhibited the expression of bcl2 associated x, apoptosis regulator (bax) and caspase 3, while it enhanced protein kinase b (akt) and glycogen synthase kinase 3 beta (gsk-3β) phosphorylation. |
2020-11-09 |
2023-08-13 |
Not clear |
| Fojan Agahi, Neda Álvarez-Ortega, Guillermina Font, Ana Juan-García, Cristina Jua. Oxidative stress, glutathione, and gene expression as key indicators in SH-SY5Y cells exposed to zearalenone metabolites and beauvericin. Toxicology letters. vol 334. 2020-11-04. PMID:32956828. |
it was further examined the expression of genes involved in cell apoptosis (casp3, bax, bcl2) and receptors of (endogenous or exogenous) estrogens (erβ and gper1), by rt-pcr in those same conditions. |
2020-11-04 |
2023-08-13 |
human |
| Fojan Agahi, Neda Álvarez-Ortega, Guillermina Font, Ana Juan-García, Cristina Jua. Oxidative stress, glutathione, and gene expression as key indicators in SH-SY5Y cells exposed to zearalenone metabolites and beauvericin. Toxicology letters. vol 334. 2020-11-04. PMID:32956828. |
also, the results revealed a significant increase in gsh/gssg ratio at all concentrations after 24 h. expression levels of casp3 and bax were up regulated by α-zel while casp3 and bcl2 were down regulated by β-zel, revealing how zea´s metabolites can induce the expression of cell apoptosis genes. |
2020-11-04 |
2023-08-13 |
human |