| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Grant R Campbell, Rachel K To, Gang Zhang, Stephen A Specto. SMAC mimetics induce autophagy-dependent apoptosis of HIV-1-infected macrophages. Cell death & disease. vol 11. issue 7. 2021-03-25. PMID:32719312. |
in contrast to cd4+ t cells, hiv-mφ are resistant to the cytopathic effects of acute hiv infection and have increased expression of cell survival factors, including x-linked inhibitor of apoptosis (xiap), baculoviral iap repeat containing (birc) 2/ciap1, beclin-1, bcl2, bcl-xl, triggering receptor expressed on myeloid cells 1, mitofusin (mfn) 1, and mfn2. |
2021-03-25 |
2023-08-13 |
human |
| Chengzhu Liao, Yuming Jin, Yuchao Li, Sie Chin Tjon. Interactions of Zinc Oxide Nanostructures with Mammalian Cells: Cytotoxicity and Photocatalytic Toxicity. International journal of molecular sciences. vol 21. issue 17. 2021-03-25. PMID:32878253. |
these ros-mediated responses induce caspase-dependent apoptosis via the activation of b-cell lymphoma 2 (bcl2), bcl2-associated x protein (bax), ccaat/enhancer-binding protein homologous protein (chop), and phosphoprotein p53 gene expressions. |
2021-03-25 |
2023-08-13 |
mouse |
| Andrew W Robert. Therapeutic development and current uses of BCL-2 inhibition. Hematology. American Society of Hematology. Education Program. vol 2020. issue 1. 2021-03-24. PMID:33275682. |
b-cell lymphoma 2 (bcl2) is a key protein regulator of apoptosis. |
2021-03-24 |
2023-08-13 |
Not clear |
| Thalita Alves Zanetti, Bruna Isabela Biazi, Giuliana Castello Coatti, Adrivanio Baranoski, Lilian Areal Marques, Amanda Cristina Corveloni, Mario Sergio Mantovan. Dimethoxycurcumin reduces proliferation and induces apoptosis in renal tumor cells more efficiently than demethoxycurcumin and curcumin. Chemico-biological interactions. vol 338. 2021-03-24. PMID:33582110. |
this dysregulation induced cell death through a caspase-independent pathway but was mediated by decrease in mtor and bcl2 mrna expression, suggesting that apoptosis occurred by autophagy. |
2021-03-24 |
2023-08-13 |
human |
| Suxia Zheng, Maolei Gong, Jing Che. Extracellular vesicles enriched with miR-150 released by macrophages regulates the TP53-IGF-1 axis to alleviate myocardial infarction. American journal of physiology. Heart and circulatory physiology. vol 320. issue 3. 2021-03-22. PMID:33164579. |
furthermore, increased expression of ev-derived mir-150 prevented cardiomyocyte apoptosis in vitro, as evidenced by downregulated bax and cleaved-caspase 3 and upregulated bcl2 and alleviated mi in vivo. |
2021-03-22 |
2023-08-13 |
mouse |
| Yang Li, Feifei Ma, Zengqiang Li, Yige Yu, Haoni Yan, Anam Tahir, Wenwen Zheng, Xiaoheng Li, Tongliang Huang, Ren-Shan G. Exposure to 4-bromodiphenyl ether during pregnancy blocks testis development in male rat fetuses. Toxicology letters. vol 342. 2021-03-22. PMID:33582287. |
in utero exposure to bde3 can promote autophagy and apoptosis of fetal leydig cells via increasing the levels of beclin1, lc3-ii, bax, and by decreasing the levels of p62 and bcl2. |
2021-03-22 |
2023-08-13 |
rat |
| Qifeng Han, Todd Bradley, Wilton B Williams, Derek W Cain, David C Montefiori, Kevin O Saunders, Robert J Parks, Regina W Edwards, Guido Ferrari, Olaf Mueller, Xiaoying Shen, Kevin J Wiehe, Steven Reed, Christopher B Fox, Wes Rountree, Nathan A Vandergrift, Yunfei Wang, Laura L Sutherland, Sampa Santra, M Anthony Moody, Sallie R Permar, Georgia D Tomaras, Mark G Lewis, Koen K A Van Rompay, Barton F Hayne. Neonatal Rhesus Macaques Have Distinct Immune Cell Transcriptional Profiles following HIV Envelope Immunization. Cell reports. vol 30. issue 5. 2021-03-16. PMID:32023469. |
transcriptome analyses of neonatal versus adult immune cells after env vaccination reveal that neonatal macaques have higher levels of the apoptosis regulator bcl2 in t cells and lower levels of the immunosuppressive interleukin-10 (il-10) receptor alpha (il10ra) mrna transcripts in t cells, b cells, natural killer (nk) cells, and monocytes. |
2021-03-16 |
2023-08-13 |
Not clear |
| Patrycja Kurowska, Ewa Mlyczyńska, Joelle Dupont, Agnieszka Ra. Novel Insights on the Corpus Luteum Function: Role of Vaspin on Porcine Luteal Cell Angiogenesis, Proliferation and Apoptosis by Activation of GRP78 Receptor and MAP3/1 Kinase Pathways. International journal of molecular sciences. vol 21. issue 18. 2021-03-15. PMID:32957618. |
porcine luteal cells were incubated with vaspin (0.1-10 ng/ml) for 24 h to 72 h and then mrna and protein expression of angiogenesis: vascular endothelial growth factor (vegfa), fibroblast growth factor 2 (fgf2), angiopoietin 1 (angpt1), vegfa receptors (vegfr1, vegfr2), apoptosis: caspase 3, bcl-2-like protein 4 (bax), b-cell lymphoma (bcl2), and proliferation: proliferating cells nuclear antigen (pcna), cyclin a factors as well as secretion of vegfa, fgf2, angt1 were measured by real-time polymerase chain reaction (pcr), immunoblotting and enzyme-linked immunosorbent assay (elisa), respectively. |
2021-03-15 |
2023-08-13 |
Not clear |
| Pradip Kumar Jaiswara, Vishal Kumar Gupta, Pratishtha Sonker, Shiv Govind Rawat, Rajan Kumar Tiwari, Chandramani Pathak, Santosh Kumar, Ajay Kuma. Nimbolide induces cell death in T lymphoma cells: Implication of altered apoptosis and glucose metabolism. Environmental toxicology. vol 36. issue 4. 2021-03-11. PMID:33274819. |
nimbolide-induced apoptosis in t lymphoma cells by altering the level of reactive oxygen species, p53, bcl2, bax, and cytochrome c, with subsequent cleavage of caspase 3. |
2021-03-11 |
2023-08-13 |
Not clear |
| Anna Kleczka, Robert Kubina, Radosław Dzik, Krzysztof Jasik, Jerzy Stojko, Krzysztof Cholewa, Agata Kabała-Dzi. Caffeic Acid Phenethyl Ester (CAPE) Induced Apoptosis in Serous Ovarian Cancer OV7 Cells by Deregulation of BCL2/BAX Genes. Molecules (Basel, Switzerland). vol 25. issue 15. 2021-03-09. PMID:32752091. |
in ov7 cells cape induced apoptosis via dysregulation of bax/bcl2 balance, while activated proapoptotic bax gene expression level was 10 times higher than bcl2. |
2021-03-09 |
2023-08-13 |
Not clear |
| Xin Chen, Tailang Yin, Baozhen Zhang, Beini Sun, Jie Chen, Tianxia Xiao, Baobei Wang, Mengxia Li, Jing Yang, Xiujun Fa. Inhibitory effects of brusatol delivered using glycosaminoglycan‑placental chondroitin sulfate A‑modified nanoparticles on the proliferation, migration and invasion of cancer cells. International journal of molecular medicine. vol 46. issue 2. 2021-03-08. PMID:32626948. |
further studies demonstrated that the plcsa‑bnps promoted the apoptosis of cancer cells more effectively and inhibited their proliferation, invasion and migration, accompanied by downregulation of matrix metalloproteinase (mmp)‑2, mmp‑9 and b‑cell cll/lymphoma 2 (bcl2) levels, but upregulation of bcl2‑associated x protein bax and cleaved caspase‑3 levels. |
2021-03-08 |
2023-08-13 |
Not clear |
| Ying Geng, Yongxia Bao, Wei Zhang, Lili Deng, Dongju Su, Hongyan Zhen. Circular RNA hsa_circ_0014130 Inhibits Apoptosis in Non-Small Cell Lung Cancer by Sponging miR-136-5p and Upregulating BCL2. Molecular cancer research : MCR. vol 18. issue 5. 2021-03-05. PMID:32060230. |
circular rna hsa_circ_0014130 inhibits apoptosis in non-small cell lung cancer by sponging mir-136-5p and upregulating bcl2. |
2021-03-05 |
2023-08-13 |
mouse |
| Yung-Che Chen, Chiu Ping Lee, Chang-Chun Hsiao, Po-Yuan Hsu, Ting-Ya Wang, Chao-Chien Wu, Tung-Ying Chao, Sum-Yee Leung, Yu-Ping Chang, Meng-Chih Li. MicroRNA-23a-3p Down-Regulation in Active Pulmonary Tuberculosis Patients with High Bacterial Burden Inhibits Mononuclear Cell Function and Phagocytosis through TLR4/TNF-α/TGF-β1/IL-10 Signaling via Targeting IRF1/SP1. International journal of molecular sciences. vol 21. issue 22. 2021-03-04. PMID:33202583. |
mir-23a-3p mimic transfection reversed esat6-induced reduction of reactive oxygen species generation, and augmented esat6-induced late apoptosis and phagocytosis, in association with down-regulations of the predicted target genes, including tumor necrosis factor (tnf)-α, tlr4, tlr2, il6, il10, notch1, il6r, bcl2, tgf-β1, sp1, and irf1. |
2021-03-04 |
2023-08-13 |
human |
| Sabine Stöckl, Georg Lindner, Shushan Li, Philipp Schuster, Sebastian Haferkamp, Ferdinand Wagner, Peter M Prodinger, Gabriele Multhoff, Melanie Boxberg, Axel Hillmann, Richard J Bauer, Susanne Grässe. SOX9 Knockout Induces Polyploidy and Changes Sensitivity to Tumor Treatment Strategies in a Chondrosarcoma Cell Line. International journal of molecular sciences. vol 21. issue 20. 2021-02-25. PMID:33076370. |
in contrast, adhesion, apoptosis and polyploidy formation are favored after sox9 deletion, probably involving bcl2 and survivin. |
2021-02-25 |
2023-08-13 |
human |
| Mohamed E Abdraboh, Zaidoon Shaker Essa, Abdelrazek B Abdelrazzak, Yousra M El-Far, Yasser Elsherbini, Mustafa M El-Zayat, Doaa A Al. Radio-sensitizing effect of a cocktail of phytochemicals on HepG2 cell proliferation, motility and survival. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 131. 2021-02-17. PMID:32892028. |
the combined treatment stimulated p53-dependent apoptosis which was indicated by the significant increase of early apoptosis marker (annexin v) expression, dna fragmentation, expression of p53 & bax and downregulation of bcl2 expression. |
2021-02-17 |
2023-08-13 |
Not clear |
| Balaji Chandrasekaran, Nisha R Dahiya, Ashish Tyagi, Venkatesh Kolluru, Uttara Saran, Becca V Baby, J Christopher States, Ahmed Q Haddad, Murali K Ankem, Chendil Damodara. Chronic exposure to cadmium induces a malignant transformation of benign prostate epithelial cells. Oncogenesis. vol 9. issue 2. 2021-02-16. PMID:32066655. |
at the molecular level, zic2 interacts with the glioma-associated oncogene family (gli) zinc finger 1 (gli1), which activates prosurvival factors (nuclear factor nfκb, b-cell lymphoma-2 (bcl2), as well as an x-linked inhibitor of apoptosis protein (xiap)) signaling in cd-exposed bph1 cells. |
2021-02-16 |
2023-08-13 |
mouse |
| Sameena Bano, Faheem Ahmed, Farha Khan, Sandeep Chand Chaudhary, M Sami. Enhancement of the cancer inhibitory effect of the bioactive food component resveratrol by nanoparticle based delivery. Food & function. vol 11. issue 4. 2021-02-16. PMID:32215382. |
moreover, at all doses nrv altered bax and bcl2 expressions which lead to the induction of apoptosis. |
2021-02-16 |
2023-08-13 |
mouse |
| Sara Cheleschi, Marcella Barbarino, Ines Gallo, Sara Tenti, Maria Bottaro, Elena Frati, Stefano Giannotti, Antonella Fioravant. Hydrostatic Pressure Regulates Oxidative Stress through microRNA in Human Osteoarthritic Chondrocytes. International journal of molecular sciences. vol 21. issue 10. 2021-02-16. PMID:32455798. |
metalloproteinases (mmps), disintegrin and metalloproteinase with thrombospondin motif (adamts)-5, type ii collagen (col2a1), mir-34a, mir-146a, mir-181a, antioxidant enzymes, and b-cell lymphoma 2 (bcl2) were evaluated by quantitative real-time polymerase chain reaction qrt-pcr, apoptosis and reactive oxygen species ros production by cytometry, and β-catenin by immunofluorescence. |
2021-02-16 |
2023-08-13 |
human |
| Boris Sabirzhanov, Oleg Makarevich, James Barrett, Isabel L Jackson, Alan I Faden, Bogdan A Stoic. Down-Regulation of miR-23a-3p Mediates Irradiation-Induced Neuronal Apoptosis. International journal of molecular sciences. vol 21. issue 10. 2021-02-16. PMID:32456284. |
this is followed by the p53-dependent up-regulation of the pro-apoptotic bcl2 family molecules, including the bh3-only molecules puma, noxa, and bim, leading to mitochondrial outer membrane permeabilization (momp) and the release of cytochrome c, which activates caspase-dependent apoptosis. |
2021-02-16 |
2023-08-13 |
Not clear |
| Viviane L Brair, Ana Lucia R S Maia, Lucas Francisco L Correia, Nathalia O Barbosa, Juliana D R Santos, Felipe Z Brandão, Jeferson F Fonseca, Ribrio Ivan T P Batista, Joanna M G Souza-Fabja. Gene expression patterns of in vivo-derived sheep blastocysts is more affected by vitrification than slow freezing technique. Cryobiology. vol 95. 2021-02-15. PMID:32554154. |
thus, this study assessed the effect of sheep embryo cryopreservation (slow freezing or vitrification) on embryo survival rate and expression of genes related to trophectoderm differentiation (cdx2), pluripotency maintenance (nanog), cell proliferation (tgfb1), mitochondrial activity (nrf1) and apoptosis (bax and bcl2). |
2021-02-15 |
2023-08-13 |
Not clear |