| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Linlin Zhang, Tiantian Ma, Qibing Tao, Wushuang Tan, Huatao Chen, Wei Liu, Pengfei Lin, Dong Zhou, Aihua Wang, Yaping Jin, Keqiong Tan. Bta-miR-34b inhibits proliferation and promotes apoptosis via the MEK/ERK pathway by targeting MAP2K1 in bovine primary Sertoli cells. Journal of animal science. vol 98. issue 10. 2021-02-15. PMID:32954430. |
microrna-34b overexpression also leads to increased cell apoptosis, with proapoptotic genes p53 and bax upregulated, while antiapoptotic gene bcl2 decreased. |
2021-02-15 |
2023-08-13 |
cattle |
| Xiaomeng Li, Mengmei Ni, Zhirui Yang, Xuxi Chen, Lishi Zhang, Jinyao Che. Bioinformatics analysis and quantitative weight of evidence assessment to map the potential mode of actions of bisphenol A. Environmental pollution (Barking, Essex : 1987). vol 273. 2021-02-15. PMID:33460868. |
the ctd-based bioinformatics analysis results showed that estrogen receptor 1, estrogen receptor 2, mitogen-activated protein kinase (mapk) 1, mapk3, bcl2 apoptosis regulator, caspase 3, bax, androgen receptor, and akt serine/threonine kinase 1 could be the common target genes, and the apoptotic process, cell proliferation, testosterone biosynthetic process, and estrogen biosynthetic process might be the shared phenotypes for different target organs. |
2021-02-15 |
2023-08-13 |
human |
| N S Samarkhazan, R Yekta, M Sayadi, S H Tackallou, R Safaralizadeh, M Mahdav. 2-NDC from dithiocarbamates improves ATRA efficiency and ROS-induced apoptosis via downregulation of Bcl2 and Survivin in human acute promyelocytic NB4 cells. Human & experimental toxicology. vol 39. issue 7. 2021-02-10. PMID:32096428. |
2-ndc from dithiocarbamates improves atra efficiency and ros-induced apoptosis via downregulation of bcl2 and survivin in human acute promyelocytic nb4 cells. |
2021-02-10 |
2023-08-13 |
human |
| N S Samarkhazan, R Yekta, M Sayadi, S H Tackallou, R Safaralizadeh, M Mahdav. 2-NDC from dithiocarbamates improves ATRA efficiency and ROS-induced apoptosis via downregulation of Bcl2 and Survivin in human acute promyelocytic NB4 cells. Human & experimental toxicology. vol 39. issue 7. 2021-02-10. PMID:32096428. |
molecular docking studies indicated that 2-ndc binds to the baculovirus inhibitor of apoptosis protein repeat domain of survivin and bcl homology 3 domain of bcl2 with various affinities. |
2021-02-10 |
2023-08-13 |
human |
| Liang Wang, Zhiliang Jia, Dacheng Xie, Tiansuo Zhao, Zhi Tan, Shuxing Zhang, Fanyang Kong, Daoyan Wei, Keping Xi. Methylation of HSP70 Orchestrates Its Binding to and Stabilization of BCL2 mRNA and Renders Pancreatic Cancer Cells Resistant to Therapeutics. Cancer research. vol 80. issue 20. 2021-02-10. PMID:32699135. |
prmt1 overexpression increased arginine methylation of hsps of 70 kda (hsp70); this methylation enhanced hsp70 binding and stabilization of bcl2 mrna through au-rich elements in 3'-untranslated region and consequentially increased bcl2 protein expression and protected cancer cells from apoptosis induced by cellular stresses and therapeutics. |
2021-02-10 |
2023-08-13 |
Not clear |
| Jing-Xue Zhang, Xue-Jing Yan, Shen Wu, Qian Liu, Jian-Min M. KLF16 overexpression deleteriously affects the proliferation and migration of retinoblastoma by transcriptionally repressing BCL2L15. Biochemical and biophysical research communications. vol 529. issue 4. 2021-02-10. PMID:32819608. |
mechanistically, bcl2 like 15 (bcl2l15), an apoptosis gene, was negatively regulated by klf16. |
2021-02-10 |
2023-08-13 |
Not clear |
| Nandini Dey, Jennifer Aske, Pradip D. Targeted Neoadjuvant Therapies in HR+/HER2-Breast Cancers: Challenges for Improving pCR. Cancers. vol 13. issue 3. 2021-02-10. PMID:33530335. |
here we propose two scenarios wherein apoptosis can be induced in er+/her2- breast cancers expressing wild type tp53 and rb genes following combinations of bcl2 inhibitor, mdm2 inhibitor, and cell-cycle inhibitor. |
2021-02-10 |
2023-08-13 |
Not clear |
| Nandini Dey, Jennifer Aske, Pradip D. Targeted Neoadjuvant Therapies in HR+/HER2-Breast Cancers: Challenges for Improving pCR. Cancers. vol 13. issue 3. 2021-02-10. PMID:33530335. |
the two combinations of drugs are (1) bcl2 inhibitor plus a cell-cycle inhibitor, which can prime the tumor cells for apoptosis, and (2) bcl2 inhibitor plus an mdm2 inhibitor. |
2021-02-10 |
2023-08-13 |
Not clear |
| Sharareh Sharifi, Pargol Ghavam Mostafavi, Roghayeh Tarasi, Ali Mashinchian Moradi, Mohammad Hadi Givianrad, Mahdi Moridi Farimani, Samad Nejad Ebrahimi, Matthias Hamburger, Hassan Nikneja. Purified compounds from marine organism sea pen induce apoptosis in human breast cancer cell MDA-MB-231 and cervical cancer cell Hela. European journal of pharmacology. vol 877. 2021-01-27. PMID:32222494. |
immunocytochemistry and western blot analyses were used to evaluate the expression of apoptosis related markers caspase 3, caspase 8, bax and bcl2 in cancer cells after treating with three compounds. |
2021-01-27 |
2023-08-13 |
human |
| Wen-Fu Xu, Zhu-Jun Wang, Kun Li, Ya-Qing Shen, Ke Lu, Xue-Yan Lv, Yu-Xi Wen, Run-Ming Ji. Huai Qi Huang-induced Apoptosis via Down-regulating PRKCH and Inhibiting RAF/MEK/ERK Pathway in Ph Current medical science. vol 40. issue 2. 2021-01-27. PMID:32337697. |
the results showed that hqh inhibited survival and promoted apoptosis of bv173 and k562 cells in a dose-dependent manner, accompanied with down-regulation of prkch mrna as well as craf, mek4, phospho-erk (perk) and bcl2 proteins, and up-regulation of cleaved caspase3 protein. |
2021-01-27 |
2023-08-13 |
Not clear |
| Shahin Asadi, Alireza Khabbazi, Shahriar Alipour, Somayeh Abolhasani, Jafar Haji, Hossein Amjadi, Ebrahim Sakhini. Promoter methylation of Bax and Bcl2 genes and their expression in patients with Behcet's disease. International journal of immunogenetics. vol 47. issue 3. 2021-01-26. PMID:31916399. |
bcl2 and bax genes are a group of signalling inducer and inhibitor genes playing a key role in the process of cellular physiological death (apoptosis). |
2021-01-26 |
2023-08-13 |
human |
| Han-A Park, Katheryn Broman, Elizabeth A Jona. Oxidative stress battles neuronal Bcl-xL in a fight to the death. Neural regeneration research. vol 16. issue 1. 2021-01-23. PMID:32788441. |
during apoptosis, pro-apoptotic bcl2 proteins such as bax and bak translocate to and oligomerize in the mitochondrial membrane. |
2021-01-23 |
2023-08-13 |
Not clear |
| Cynthia Lebeaupin, Marina Blanc, Déborah Vallée, Harald Keller, Béatrice Bailly-Maitr. BAX inhibitor-1: between stress and survival. The FEBS journal. vol 287. issue 9. 2021-01-18. PMID:31841271. |
bcl2 associated x, apoptosis regulator (bax) inhibitor-1 (bi-1), also named transmembrane bax inhibitor motif containing-6, is a highly conserved endoplasmic reticulum (er) transmembrane protein. |
2021-01-18 |
2023-08-13 |
Not clear |
| Chenchen Li, Wei Zhao, Xuan Pan, Xiaoyou Li, Fei Yan, Siwen Liu, Jifeng Feng, Jianwei L. LncRNA KTN1-AS1 promotes the progression of non-small cell lung cancer via sponging of miR-130a-5p and activation of PDPK1. Oncogene. vol 39. issue 39. 2021-01-13. PMID:32820252. |
ktn1-as1 knockdown inhibited cell growth and proliferation, increased apoptosis, and modulated the expression of cell cycle- and apoptosis-related proteins (cyclin a1, cyclin-dependent kinase 2, bcl2, and bax) in nsclc cell lines and tumour xenografts in nude mice. |
2021-01-13 |
2023-08-13 |
mouse |
| Li Xiao, Zhennan Peng, Anqi Zhu, Renxing Xue, Renming Lu, Jing Mi, Shaowei Xi, Wei Chen, Songshan Jian. Inhibition of RUNX1 promotes cisplatin-induced apoptosis in ovarian cancer cells. Biochemical pharmacology. vol 180. 2021-01-11. PMID:32579960. |
we further confirmed that mir-17~92 cluster could enhance cisplatin-induced apoptosis by directly targeting bcl2 3'utr. |
2021-01-11 |
2023-08-13 |
Not clear |
| Li Xiao, Zhennan Peng, Anqi Zhu, Renxing Xue, Renming Lu, Jing Mi, Shaowei Xi, Wei Chen, Songshan Jian. Inhibition of RUNX1 promotes cisplatin-induced apoptosis in ovarian cancer cells. Biochemical pharmacology. vol 180. 2021-01-11. PMID:32579960. |
since rescue experiments proved that runx1 could repress cisplatin-induced apoptosis by up-regulating bcl2 via mir-17~92 cluster, combining runx1 inhibitor ro5-3335 and cisplatin showed synergic effect in triggering oc cell apoptosis. |
2021-01-11 |
2023-08-13 |
Not clear |
| Farhad Eslami, Majid Mahdavi, Esmaeil Babaei, Bashdar Mahmud Hussen, Hossein Mostafavi, Ahmad Shahbazi, Hazha Jamal Hidaya. Down-regulation of Survivin and Bcl-2 concomitant with the activation of caspase-3 as a mechanism of apoptotic death in KG1a and K562 cells upon exposure to a derivative from ciprofloxacin family. Toxicology and applied pharmacology. vol 409. 2021-01-11. PMID:33171188. |
the qrt pcr analysis showed that 4-dmocp induces apoptosis in both cell lines via the down-regulation of survivin and bcl2, up-regulation of caspase-8 and -9, as well as a time-dependent increase in the bax/bcl2 transcripts. |
2021-01-11 |
2023-08-13 |
human |
| Yansong Li, Shuhong Ren, Jingwen Xia, Yong Wei, Yinhua X. EIF4A3-Induced circ-BNIP3 Aggravated Hypoxia-Induced Injury of H9c2 Cells by Targeting miR-27a-3p/BNIP3. Molecular therapy. Nucleic acids. vol 19. 2021-01-10. PMID:31923741. |
bcl2 interaction protein 3 (bnip3) can be upregulated by hypoxia and participates in the mediation of hypoxia-activated apoptosis in cardiac myocyte death. |
2021-01-10 |
2023-08-13 |
Not clear |
| Emílio Pereira de Brito Neto, Evelyze Pinheiro Dos Reis, Jurandy Mauro Penitente-Filho, José Carlos Montes, Karine Assis Costa, Susana Amaral Teixeira, Walmir Silva, Rogério Pinho, José Domingos Guimarães, Eduardo Paulino da Costa, Marcos Soares Lopes, Simone Eliza Facioni Guimarãe. Expression of apoptosis and myogenesis related genes during prenatal life in two divergent breeds of pigs. Theriogenology. vol 145. 2021-01-07. PMID:32004820. |
expression of apoptosis and myogenesis related genes (bax, bcl2, fgf4, ihh, hhip, shh, sox2, wnt1 and wnt4) were evaluated by quantitative real time pcr. |
2021-01-07 |
2023-08-13 |
Not clear |
| Yongxiang Xie, Fang Lan, Jie Zhao, Wei Sh. Hirudin improves renal interstitial fibrosis by reducing renal tubule injury and inflammation in unilateral ureteral obstruction (UUO) mice. International immunopharmacology. vol 81. 2021-01-07. PMID:32066115. |
the apoptosis related proteins (pro-caspase3, pro-caspase9, bcl2 and bax) expression was also down-regulated in renal tissues of uuo rats. |
2021-01-07 |
2023-08-13 |
mouse |