| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhenzhen Meng, Ying Liu, Jie Wang, Hongjia Fan, Huan Fang, Sha Li, Lin Yuan, Cuicui Liu, You Peng, Weiwei Zhao, Lulu Wang, Jing Li, Jing Fen. Histone demethylase KDM7A is required for stem cell maintenance and apoptosis inhibition in breast cancer. Journal of cellular physiology. vol 235. issue 2. 2020-10-13. PMID:31236965. |
in addition, kdm7a knockdown promoted apoptosis through decreasing bcl2 expression and bad phosphorylation in breast cancer (brca). |
2020-10-13 |
2023-08-13 |
Not clear |
| Zhenzhen Meng, Ying Liu, Jie Wang, Hongjia Fan, Huan Fang, Sha Li, Lin Yuan, Cuicui Liu, You Peng, Weiwei Zhao, Lulu Wang, Jing Li, Jing Fen. Histone demethylase KDM7A is required for stem cell maintenance and apoptosis inhibition in breast cancer. Journal of cellular physiology. vol 235. issue 2. 2020-10-13. PMID:31236965. |
furthermore, restoring kdm7a and bcl2 expression rescued apoptosis inhibition in breast cancer, suggesting that kdm7a inhibited apoptosis by upregulating the bcl2 level in breast cancer. |
2020-10-13 |
2023-08-13 |
Not clear |
| Mahdieh Safaei, Hadi Maleki, Hamidreza Soleimanpour, Amir Norouzy, Hossein Shahbani Zahiri, Hojatollah Vali, Kambiz Akbari Noghab. Development of a novel method for the purification of C-phycocyanin pigment from a local cyanobacterial strain Limnothrix sp. NS01 and evaluation of its anticancer properties. Scientific reports. vol 9. issue 1. 2020-10-13. PMID:31263160. |
the reduced expression levels of anti-apoptotic proteins, bcl2 and stat3, plus cell cycle regulator protein, cyclin d1, using real-time pcr confirm that the c-pc-induced death of mcf-7 human breast cancer cells occurred through the mitochondrial pathway of apoptosis. |
2020-10-13 |
2023-08-13 |
human |
| Gilad Itchaki, Jennifer R Brow. The potential of venetoclax (ABT-199) in chronic lymphocytic leukemia. Therapeutic advances in hematology. vol 7. issue 5. 2020-10-01. PMID:27695617. |
although bcl2 overexpression is not genetically driven in chronic lymphocytic leukemia (cll), it is nearly universal and represents a highly important and prevalent mechanism of apoptosis evasion, making it an attractive therapeutic target. |
2020-10-01 |
2023-08-13 |
Not clear |
| Ramu Venkatesan, Yong Un Park, Eunhee Ji, Eui-Ju Yeo, Sun Yeou Ki. Malathion increases apoptotic cell death by inducing lysosomal membrane permeabilization in N2a neuroblastoma cells: a model for neurodegeneration in Alzheimer's disease. Cell death discovery. vol 3. 2020-10-01. PMID:28487766. |
malathion reduced cell viability mainly by apoptosis through mitochondrial dysfunction in n2a cells, as judged by an increase in the level of the pro-apoptotic protein bax and decrease in the levels of the anti-apoptotic proteins p-akt and bcl2, resulting in cytochrome |
2020-10-01 |
2023-08-13 |
mouse |
| Jian Bo, Xiaojuan Wang, Jie Li, Wenqing Wang, Jinqian Zhan. Consecutive stimulation of HBsAg promotes the viability of the human B lymphoblastoid cell line IM-9 through regulating the SIRT1-NF-κB pathway. Oncology letters. vol 14. issue 1. 2020-10-01. PMID:28693188. |
hbsag upregulated the expression of anti-apoptotic b-cell lymphoma-extra-large and b-cell lymphoma 2 proteins, and inactivated the intrinsic apoptosis pathway by reducing bcl2 associated x, apoptosis regulator expression and increasing the expression of sirtuin 1 (sirt1) and nuclear factor-κb (nf-κb). |
2020-10-01 |
2023-08-13 |
human |
| Yingdong Xu, Na Deng, Xiaoou Wang, Yinghui Chen, Guiji Li, Hua Fa. RKTG overexpression inhibits proliferation and induces apoptosis of human leukemia cells via suppression of the ERK and PI3K/AKT signaling pathways. Oncology letters. vol 14. issue 1. 2020-10-01. PMID:28693259. |
furthermore, western blotting showed that rktg overexpression significantly increased the level of cleaved caspase 3, b-cell lymphoma 2 (bcl2)-associated x apoptosis regulator and reduced the level of bcl-2. |
2020-10-01 |
2023-08-13 |
human |
| Ying Liang, Jiao Liu, Ting Liu, Xingsheng Yan. Anti-c-Met antibody bioconjugated with hollow gold nanospheres as a novel nanomaterial for targeted radiation ablation of human cervical cancer cell. Oncology letters. vol 14. issue 2. 2020-10-01. PMID:28789447. |
the anti-c-met/hgn x-ray-treated group also evidently overexpressed caspase-3 and bcl2 associated x, apoptosis regulator. |
2020-10-01 |
2023-08-13 |
human |
| Yun-Long Tang, Yan Zhou, Ling-Ling Cheng, Yong-Zhong Su, Chun-Bin Wan. BCL2/Ki-67 index predict survival in germinal center B-cell-like diffuse large B-cell lymphoma. Oncology letters. vol 14. issue 3. 2020-10-01. PMID:28927145. |
bcl2 apoptosis regulator (bcl2) and marker of proliferation ki-67 (ki-67) are established prognostic markers, which have traditionally been assessed separately in dlbcl. |
2020-10-01 |
2023-08-13 |
Not clear |
| Ga Bin Park, Jee-Yeong Jeong, Daejin Ki. Ampelopsin-induced reactive oxygen species enhance the apoptosis of colon cancer cells by activating endoplasmic reticulum stress-mediated AMPK/MAPK/XAF1 signaling. Oncology letters. vol 14. issue 6. 2020-10-01. PMID:29250183. |
additionally, sp600125 (a jnk inhibitor) and sb203580 (a p38-mapk inhibitor) effectively inhibited apoptosis and attenuated the expression of x-linked iap-associated factor 1 (xaf1) and apoptotic bcl-2 family proteins (bcl2 antagonist/killer 1 and bcl2-associated x protein) in amp-treated colon cancer cells. |
2020-10-01 |
2023-08-13 |
Not clear |
| Xueqin Pang, Rui Li, Dongtao Shi, Xudong Pan, Chen Ma, Guangbo Zhang, Chuanyong Mu, Weichang Che. Knockdown of Rhotekin 2 expression suppresses proliferation and induces apoptosis in colon cancer cells. Oncology letters. vol 14. issue 6. 2020-10-01. PMID:29250187. |
furthermore, the silencing of rtkn2 in the cells induced apoptosis by reducing the expression level of bax and increasing the expression level of bcl2. |
2020-10-01 |
2023-08-13 |
human |
| Lina Sun, Lei Zhao, Dan Li, Shuai Xu, Xuexin Hou, Zhenjun L. Low risk HPV-6E6 induces apoptosis in bone marrow-derived dendritic cells. Oncology letters. vol 15. issue 1. 2020-10-01. PMID:29422974. |
furthermore, the expression of apoptosis-associated proteins, including p53, bcl2 associated x apoptosis regulator (bax), bcl2 homologous antagonist/killer (bak) and cytochrome |
2020-10-01 |
2023-08-13 |
mouse |
| Yuanyi Zhang, Yan Qi, Yang Zhao, Hongyan Sun, Jingyan Ge, Zhonghui Li. Activin A induces apoptosis of mouse myeloma cells via the mitochondrial pathway. Oncology letters. vol 15. issue 2. 2020-10-01. PMID:29434978. |
in addition, activin a-induced promotion of ns-1 cell apoptosis was accompanied by upregulated expression of bcl2 associated x, apoptosis regulator (bax), but downregulated expression of b cell lymphoma-2 (bcl-2), resulting in an increase of the bax/bcl-2 ratio. |
2020-10-01 |
2023-08-13 |
mouse |
| Yuanyuan Zhang, Jianchun Lian, Xiaowei Wan. Actein inhibits cell proliferation and migration and promotes cell apoptosis in human non-small cell lung cancer cells. Oncology letters. vol 15. issue 3. 2020-10-01. PMID:29435050. |
the protein expression levels of cytoplasmic bcl2 apoptosis regulator (bcl-2) and bcl2 associated x (bax) were markedly decreased, while the protein expression levels of mitochondrial bax, caspase-3, -9 and cytochrome |
2020-10-01 |
2023-08-13 |
human |
| Rui Li, Hongxia Zhang, Xiling Zhen. MiR-34c induces apoptosis and inhibits the viability of M4e cells by targeting BCL2. Oncology letters. vol 15. issue 3. 2020-10-01. PMID:29435079. |
mir-34c induces apoptosis and inhibits the viability of m4e cells by targeting bcl2. |
2020-10-01 |
2023-08-13 |
Not clear |
| Rui Li, Hongxia Zhang, Xiling Zhen. MiR-34c induces apoptosis and inhibits the viability of M4e cells by targeting BCL2. Oncology letters. vol 15. issue 3. 2020-10-01. PMID:29435079. |
transfection of lenti-mir-34c was able to significantly inhibit cell viability (p<0.01), increase the percentage of cells undergoing apoptosis (p<0.001) and downregulate bcl2 protein expression (p<0.01) in m4e cells. |
2020-10-01 |
2023-08-13 |
Not clear |
| Bo Diao, Ying Liu, Guo-Zheng Xu, Yi Zhang, Jun Xie, Jie Gon. The role of galectin-3 in the tumorigenesis and progression of pituitary tumors. Oncology letters. vol 15. issue 4. 2020-10-01. PMID:29545898. |
meanwhile, bcl2 associated x, apoptosis regulator (bax), caspase-3 and matrix metalloproteinase 7 (mmp7) protein expression levels were analyzed by western blotting. |
2020-10-01 |
2023-08-13 |
rat |
| Shuo Tu, Xia-Li Zhang, Hui-Fang Wan, Yan-Qin Xia, Zhuo-Qi Liu, Xiao-Hong Yang, Fu-Sheng Wa. Effect of taurine on cell proliferation and apoptosis human lung cancer A549 cells. Oncology letters. vol 15. issue 4. 2020-10-01. PMID:29552188. |
western blot analysis was performed to examine the levels of p53 upregulated modulator of apoptosis (puma), bcl2, apoptosis regulator (bcl-2) and bcl2-associated x, apoptosis regulator (bax) in a549 cells. |
2020-10-01 |
2023-08-13 |
mouse |
| Zhaodi Zheng, Wenzhen Zhu, Bingwu Yang, Rongfei Chai, Tingting Liu, Fenglin Li, Guanghui Ren, Shuhua Ji, Shan Liu, Guorong L. The co-treatment of metformin with flavone synergistically induces apoptosis through inhibition of PI3K/AKT pathway in breast cancer cells. Oncology letters. vol 15. issue 4. 2020-10-01. PMID:29552226. |
the combination decreased the protein expression of mdmx, activated p53 through the pi3k/akt signaling pathway, regulated p53 downstream target genes bcl-2 apoptosis regulator, bcl2 associated x apoptosis regulator and cleaved caspase3, subsequently inducing apoptosis in mda-mb-231 and mcf-7 breast cancer cells. |
2020-10-01 |
2023-08-13 |
human |
| Zhonglun Liu, Xiaohong Wu, Jingjing Lv, Hui Sun, Feiqin Zho. Resveratrol induces p53 in colorectal cancer through SET7/9. Oncology letters. vol 17. issue 4. 2020-10-01. PMID:30881498. |
additionally, resveratrol enhanced the expression of tumour protein p53 (p53) and p53 target genes, including bcl2 associated x, apoptosis regulator and bcl2 binding component 3 that have a pivotal role in p53-dependent apoptosis. |
2020-10-01 |
2023-08-13 |
Not clear |