| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yonghong Luo, Chuanchuan Fang, Lan Jin, Huafeng Ding, Yuanyuan Lyu, Guantai N. The microRNA212 regulated PEA15 promotes ovarian cancer progression by inhibiting of apoptosis. Journal of Cancer. vol 11. issue 6. 2020-09-28. PMID:32047549. |
in addition, we proved knockdown of pea15 inhibits oc cell proliferation and induces cell apoptosis by bcl2 downregulation and bax and cleaved caspase-3 upregulation. |
2020-09-28 |
2023-08-13 |
Not clear |
| Jie Zhang, Yiyi Li, Chao Wang, Yaya Wang, Yangyang Zhang, Liqin Huang, Zhaohui Zhan. Lysophosphatidic Acid Induces Apoptosis of PC12 Cells Through LPA1 Receptor/LPA2 Receptor/MAPK Signaling Pathway. Frontiers in molecular neuroscience. vol 13. 2020-09-28. PMID:32116549. |
lpa elicits the activation of erk1/2, p38, and jnk pathways, decreases the expression of bcl2, promotes the translocation of bax, and enhances the activation of caspase-3, resulting in mitochondrial dysfunction and cell apoptosis. |
2020-09-28 |
2023-08-13 |
Not clear |
| Xuefeng Jiang, Yusheng Liu, Guijuan Zhang, Shujun Lin, Jieyan Wu, Xianxin Yan, Yi Ma, Min M. Aloe-Emodin Induces Breast Tumor Cell Apoptosis through Upregulation of miR-15a/miR-16-1 That Suppresses BCL2. Evidence-based complementary and alternative medicine : eCAM. vol 2020. 2020-09-28. PMID:32190086. |
aloe-emodin induces breast tumor cell apoptosis through upregulation of mir-15a/mir-16-1 that suppresses bcl2. |
2020-09-28 |
2023-08-13 |
Not clear |
| Bibo Yuan, Juan Hao, Qian Zhang, Yan Wang, Yu Zh. Role of Bcl-2 on drug resistance in breast cancer polyploidy-induced spindle poisons. Oncology letters. vol 19. issue 3. 2020-09-28. PMID:32194662. |
the expression of f-box and wd repeat domain containing 7 (fbw7) was decreased, while the expression of mcl1 apoptosis regulator bcl2 family member (mcl-1) and bcl-2 was increased, and caspase-3/9 and bax were not expressed in mda-mb-231 cells. |
2020-09-28 |
2023-08-13 |
Not clear |
| Chawalit Chatupheeraphat, Chanin Nantasenamat, Kamolchanok Deesrisak, Sittiruk Roytrakul, Usanarat Anurathapan, Dalina Tanyon. Bioinformatics and experimental studies of anti-leukemic activity from 6-gingerol demonstrate its role in p53 mediated apoptosis pathway. EXCLI journal. vol 19. 2020-09-28. PMID:32483405. |
in addition, p53, bax and bcl2 could be involved in the apoptosis pathway of these leukemic cells. |
2020-09-28 |
2023-08-13 |
Not clear |
| Sanjay Kumar, Paul B Tchounwo. Trisenox Disrupts MDM2-DAXX-HAUSP Complex and Induces Apoptosis in a Mouse Model of Acute Leukemia. Journal of Cancer. vol 11. issue 15. 2020-09-28. PMID:32489456. |
it also caused apoptosis through upregulation of caspase 3 and bax expression, and down-regulation of bcl2 expression. |
2020-09-28 |
2023-08-13 |
mouse |
| Kaili Ma, Guo Chen, Wenhui Li, Oliver Kepp, Yushan Zhu, Quan Che. Mitophagy, Mitochondrial Homeostasis, and Cell Fate. Frontiers in cell and developmental biology. vol 8. 2020-09-28. PMID:32671064. |
bcl2 family proteins interact within family members to regulate mitochondrial outer membrane permeabilization and apoptosis. |
2020-09-28 |
2023-08-13 |
Not clear |
| Fatemeh Taherkhani, Kamran Mousavi Hosseini, Sanaz Zebardast, Koorosh Goodarzvand Chegini, Nematollah Gheib. Anti proliferative and apoptotic effects on pancreatic cancer cell lines indicate new roles for ANGPTL8 (Betatrophin). Genetics and molecular biology. vol 43. issue 3. 2020-09-28. PMID:32745158. |
moreover, the induction of apoptosis by angptl8 occurred by the down-regulation of bcl2. |
2020-09-28 |
2023-08-13 |
Not clear |
| Jiarui Yu, Wei Wang, Weinan Yao, Zhao Yang, Peng Gao, Meiyue Liu, Huan Wang, Siyuan Chen, Dan Wang, Weixi Wang, Guogui Su. Gambogic acid affects ESCC progression through regulation of PI3K/AKT/mTOR signal pathway. Journal of Cancer. vol 11. issue 19. 2020-09-28. PMID:32913452. |
meanwhile, ga induced dose-dependent apoptosis of escc cells, repressed the expression of bcl2 and up-regulated the levels of bax protein, cleaved-parp1 and cleaved-caspase 3/9. |
2020-09-28 |
2023-08-13 |
Not clear |
| Qiao Li, HaiTao Pan, QingHuai Li. MicroRNA-15a modulates lens epithelial cells apoptosis and proliferation through targeting B-cell lymphoma-2 and E2F transcription factor 3 in age-related cataracts. Bioscience reports. vol 39. issue 12. 2020-09-25. PMID:31737898. |
importantly, b-cell lymphoma-2 (bcl2) and e2f transcription factor 3 (e2f3) exert crucial roles in cell apoptosis and cell proliferation. |
2020-09-25 |
2023-08-13 |
human |
| Qiao Li, HaiTao Pan, QingHuai Li. MicroRNA-15a modulates lens epithelial cells apoptosis and proliferation through targeting B-cell lymphoma-2 and E2F transcription factor 3 in age-related cataracts. Bioscience reports. vol 39. issue 12. 2020-09-25. PMID:31737898. |
in addition, microrna-15a overexpression induced cell apoptosis and repressed cell proliferation through suppressing bcl2 and e2f3. |
2020-09-25 |
2023-08-13 |
human |
| Qiao Li, HaiTao Pan, QingHuai Li. MicroRNA-15a modulates lens epithelial cells apoptosis and proliferation through targeting B-cell lymphoma-2 and E2F transcription factor 3 in age-related cataracts. Bioscience reports. vol 39. issue 12. 2020-09-25. PMID:31737898. |
in conclusion, we demonstrated that microrna-15a triggered apoptosis and repressed the proliferation of hle-b3 cells by modulating bcl2 and e2f3. |
2020-09-25 |
2023-08-13 |
human |
| b' Sibel \\xc3\\x96zda\\xc5\\x9f, Bora Ta\\xc5\\x9ftekin, Seren G G\\xc3\\xbcrgen, Talih \\xc3\\x96zda\\xc5\\x9f, Aykut Pelit, Sanem O Erkan, Birg\\xc3\\xbcl Tuhanio\\xc4\\x9flu, Birg\\xc3\\xbcl G\\xc3\\xbclnar, Orhan G\\xc3\\xb6rg\\xc3\\xbcl\\xc3\\xb. Pterostilbene protects cochlea from ototoxicity in streptozotocin-induced diabetic rats by inhibiting\\xc2\\xa0apoptosis. PloS one. vol 15. issue 7. 2020-09-24. PMID:32722679.' |
pts treatment also reduced cell apoptosis in a dose-dependent manner by increasing the mrna expression of the anti-apoptosis bcl2 gene and by decreasing the mrna expressions of both the pro-apoptosis bax gene and its effector casp-3 and the ratio of bax/bcl-2 in a dose-dependent manner (p < 0.05 compared to dm for all). |
2020-09-24 |
2023-08-13 |
rat |
| Chen Zhang, Chengshun Yang, Na Li, Xueqing Liu, Junlin He, Xuemei Chen, Yubin Ding, Chao Tong, Chuan Peng, Hubin Yin, Yingxiong Wang, Rufei Ga. Elevated insulin levels compromise endometrial decidualization in mice with decrease in uterine apoptosis in early-stage pregnancy. Archives of toxicology. vol 93. issue 12. 2020-09-23. PMID:31642978. |
all these results on flow cytometry, transmission electron microscopy and western blotting of bax, bcl2, cleaved caspase3, cleaved parp proteins level showed that decidual cells apoptosis was significantly decreased. |
2020-09-23 |
2023-08-13 |
mouse |
| Correction: Circular RNA hsa_circ_0014130 Inhibits Apoptosis in Non-Small Cell Lung Cancer by Sponging miR-136-5p and Upregulating BCL2. Molecular cancer research : MCR. vol 18. issue 7. 2020-09-17. PMID:32616621. |
correction: circular rna hsa_circ_0014130 inhibits apoptosis in non-small cell lung cancer by sponging mir-136-5p and upregulating bcl2. |
2020-09-17 |
2023-08-13 |
Not clear |
| Prem Prakash Kushwaha, Atul Kumar Singh, Mohd Shuaib, Kumari Sunita Prajapati, Pothabathula Seshu Vardhan, Sanjay Gupta, Shashank Kuma. 3-O-(E)-p-Coumaroyl betulinic acid possess anticancer activity and inhibit Notch signaling pathway in breast cancer cells and mammosphere. Chemico-biological interactions. vol 328. 2020-09-17. PMID:32702347. |
cb treatment induced early apoptosis in breast cancer cells as evident by increase in cleaved caspase-3, decrease in bcl2 and survivin, surge in reactive oxygen species and disruption of mitochondrial membrane potential. |
2020-09-17 |
2023-08-13 |
human |
| Christopher Letson, Eric Padro. Non-canonical transcriptional consequences of BET inhibition in cancer. Pharmacological research. vol 150. 2020-08-24. PMID:31698067. |
downregulation of the myc oncogene, cdk6, bcl2 and fosl1 are just a few examples of the effects of bet inhibitors that can lead to cell cycle arrest and apoptosis in cancer cells. |
2020-08-24 |
2023-08-13 |
Not clear |
| Chenlong Song, Yang Han, Huan Luo, Zhiwei Qin, Zhengqian Chen, Yuan Liu, Su Lu, Huimin Sun, Chongzhi Zho. HOXA10 induces BCL2 expression, inhibits apoptosis, and promotes cell proliferation in gastric cancer. Cancer medicine. vol 8. issue 12. 2020-08-21. PMID:31364281. |
hoxa10 induces bcl2 expression, inhibits apoptosis, and promotes cell proliferation in gastric cancer. |
2020-08-21 |
2023-08-13 |
Not clear |
| Chenlong Song, Yang Han, Huan Luo, Zhiwei Qin, Zhengqian Chen, Yuan Liu, Su Lu, Huimin Sun, Chongzhi Zho. HOXA10 induces BCL2 expression, inhibits apoptosis, and promotes cell proliferation in gastric cancer. Cancer medicine. vol 8. issue 12. 2020-08-21. PMID:31364281. |
by performing western blot, chromatin immunoprecipitation and quantitative pcr (chip-qpcr), and rescue experiment, we found that hoxa10 might bind to bcl2 promoter region, induce its expression, and thus inhibit intrinsic apoptosis pathway. |
2020-08-21 |
2023-08-13 |
Not clear |
| Chenlong Song, Yang Han, Huan Luo, Zhiwei Qin, Zhengqian Chen, Yuan Liu, Su Lu, Huimin Sun, Chongzhi Zho. HOXA10 induces BCL2 expression, inhibits apoptosis, and promotes cell proliferation in gastric cancer. Cancer medicine. vol 8. issue 12. 2020-08-21. PMID:31364281. |
in summary, our study indicated that hoxa10 was upregulated in gc, and that hoxa10 might promote cell proliferation by elevating bcl2 expression and inhibiting apoptosis. |
2020-08-21 |
2023-08-13 |
Not clear |