| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qiao Li, HaiTao Pan, QingHuai Li. MicroRNA-15a modulates lens epithelial cells apoptosis and proliferation through targeting B-cell lymphoma-2 and E2F transcription factor 3 in age-related cataracts. Bioscience reports. vol 39. issue 12. 2020-09-25. PMID:31737898. |
importantly, b-cell lymphoma-2 (bcl2) and e2f transcription factor 3 (e2f3) exert crucial roles in cell apoptosis and cell proliferation. |
2020-09-25 |
2023-08-13 |
human |
| Qiao Li, HaiTao Pan, QingHuai Li. MicroRNA-15a modulates lens epithelial cells apoptosis and proliferation through targeting B-cell lymphoma-2 and E2F transcription factor 3 in age-related cataracts. Bioscience reports. vol 39. issue 12. 2020-09-25. PMID:31737898. |
in addition, microrna-15a overexpression induced cell apoptosis and repressed cell proliferation through suppressing bcl2 and e2f3. |
2020-09-25 |
2023-08-13 |
human |
| Qiao Li, HaiTao Pan, QingHuai Li. MicroRNA-15a modulates lens epithelial cells apoptosis and proliferation through targeting B-cell lymphoma-2 and E2F transcription factor 3 in age-related cataracts. Bioscience reports. vol 39. issue 12. 2020-09-25. PMID:31737898. |
in conclusion, we demonstrated that microrna-15a triggered apoptosis and repressed the proliferation of hle-b3 cells by modulating bcl2 and e2f3. |
2020-09-25 |
2023-08-13 |
human |
| b' Sibel \\xc3\\x96zda\\xc5\\x9f, Bora Ta\\xc5\\x9ftekin, Seren G G\\xc3\\xbcrgen, Talih \\xc3\\x96zda\\xc5\\x9f, Aykut Pelit, Sanem O Erkan, Birg\\xc3\\xbcl Tuhanio\\xc4\\x9flu, Birg\\xc3\\xbcl G\\xc3\\xbclnar, Orhan G\\xc3\\xb6rg\\xc3\\xbcl\\xc3\\xb. Pterostilbene protects cochlea from ototoxicity in streptozotocin-induced diabetic rats by inhibiting\\xc2\\xa0apoptosis. PloS one. vol 15. issue 7. 2020-09-24. PMID:32722679.' |
pts treatment also reduced cell apoptosis in a dose-dependent manner by increasing the mrna expression of the anti-apoptosis bcl2 gene and by decreasing the mrna expressions of both the pro-apoptosis bax gene and its effector casp-3 and the ratio of bax/bcl-2 in a dose-dependent manner (p < 0.05 compared to dm for all). |
2020-09-24 |
2023-08-13 |
rat |
| Chen Zhang, Chengshun Yang, Na Li, Xueqing Liu, Junlin He, Xuemei Chen, Yubin Ding, Chao Tong, Chuan Peng, Hubin Yin, Yingxiong Wang, Rufei Ga. Elevated insulin levels compromise endometrial decidualization in mice with decrease in uterine apoptosis in early-stage pregnancy. Archives of toxicology. vol 93. issue 12. 2020-09-23. PMID:31642978. |
all these results on flow cytometry, transmission electron microscopy and western blotting of bax, bcl2, cleaved caspase3, cleaved parp proteins level showed that decidual cells apoptosis was significantly decreased. |
2020-09-23 |
2023-08-13 |
mouse |
| Correction: Circular RNA hsa_circ_0014130 Inhibits Apoptosis in Non-Small Cell Lung Cancer by Sponging miR-136-5p and Upregulating BCL2. Molecular cancer research : MCR. vol 18. issue 7. 2020-09-17. PMID:32616621. |
correction: circular rna hsa_circ_0014130 inhibits apoptosis in non-small cell lung cancer by sponging mir-136-5p and upregulating bcl2. |
2020-09-17 |
2023-08-13 |
Not clear |
| Prem Prakash Kushwaha, Atul Kumar Singh, Mohd Shuaib, Kumari Sunita Prajapati, Pothabathula Seshu Vardhan, Sanjay Gupta, Shashank Kuma. 3-O-(E)-p-Coumaroyl betulinic acid possess anticancer activity and inhibit Notch signaling pathway in breast cancer cells and mammosphere. Chemico-biological interactions. vol 328. 2020-09-17. PMID:32702347. |
cb treatment induced early apoptosis in breast cancer cells as evident by increase in cleaved caspase-3, decrease in bcl2 and survivin, surge in reactive oxygen species and disruption of mitochondrial membrane potential. |
2020-09-17 |
2023-08-13 |
human |
| Christopher Letson, Eric Padro. Non-canonical transcriptional consequences of BET inhibition in cancer. Pharmacological research. vol 150. 2020-08-24. PMID:31698067. |
downregulation of the myc oncogene, cdk6, bcl2 and fosl1 are just a few examples of the effects of bet inhibitors that can lead to cell cycle arrest and apoptosis in cancer cells. |
2020-08-24 |
2023-08-13 |
Not clear |
| Chenlong Song, Yang Han, Huan Luo, Zhiwei Qin, Zhengqian Chen, Yuan Liu, Su Lu, Huimin Sun, Chongzhi Zho. HOXA10 induces BCL2 expression, inhibits apoptosis, and promotes cell proliferation in gastric cancer. Cancer medicine. vol 8. issue 12. 2020-08-21. PMID:31364281. |
hoxa10 induces bcl2 expression, inhibits apoptosis, and promotes cell proliferation in gastric cancer. |
2020-08-21 |
2023-08-13 |
Not clear |
| Chenlong Song, Yang Han, Huan Luo, Zhiwei Qin, Zhengqian Chen, Yuan Liu, Su Lu, Huimin Sun, Chongzhi Zho. HOXA10 induces BCL2 expression, inhibits apoptosis, and promotes cell proliferation in gastric cancer. Cancer medicine. vol 8. issue 12. 2020-08-21. PMID:31364281. |
by performing western blot, chromatin immunoprecipitation and quantitative pcr (chip-qpcr), and rescue experiment, we found that hoxa10 might bind to bcl2 promoter region, induce its expression, and thus inhibit intrinsic apoptosis pathway. |
2020-08-21 |
2023-08-13 |
Not clear |
| Chenlong Song, Yang Han, Huan Luo, Zhiwei Qin, Zhengqian Chen, Yuan Liu, Su Lu, Huimin Sun, Chongzhi Zho. HOXA10 induces BCL2 expression, inhibits apoptosis, and promotes cell proliferation in gastric cancer. Cancer medicine. vol 8. issue 12. 2020-08-21. PMID:31364281. |
in summary, our study indicated that hoxa10 was upregulated in gc, and that hoxa10 might promote cell proliferation by elevating bcl2 expression and inhibiting apoptosis. |
2020-08-21 |
2023-08-13 |
Not clear |
| Kelly Stam, Zongye Cai, Nikki van der Velde, Richard van Duin, Esther Lam, Jolanda van der Velden, Alexander Hirsch, Dirk J Duncker, Daphne Merku. Cardiac remodelling in a swine model of chronic thromboembolic pulmonary hypertension: comparison of right vs. left ventricle. The Journal of physiology. vol 597. issue 17. 2020-08-20. PMID:31194256. |
rv remodelling in our cteph swine model is associated with increased expression of the genes involved in inflammation (tgfβ), oxidative stress (rock2, nox1 and nox4), and apoptosis (bcl2 and caspase-3). |
2020-08-20 |
2023-08-13 |
Not clear |
| Farhad Shibani, Ali Sahamsizadeh, Iman Fatemi, Mohammad Allahtavakoli, Jalal Hasanshahi, Mohammadreza Rahmani, Mahdieh Azin, Mahsa Hassanipour, Nazanin Mozafari, Ayat Kaeid. Effect of oleuropein on morphine-induced hippocampus neurotoxicity and memory impairments in rats. Naunyn-Schmiedeberg's archives of pharmacology. vol 392. issue 11. 2020-08-20. PMID:31236657. |
in order to evaluate the cleaved caspase-3, bax, and bcl2 protein expression (as biochemical markers of apoptosis) in ca1 area of hippocampus tissue, the western blot test was used. |
2020-08-20 |
2023-08-13 |
rat |
| Noelia P Leopardo, Mariela E Velazquez, Santiago Cortasa, Candela R González, Alfredo D Vitull. A dual death/survival role of autophagy in the adult ovary of Lagostomus maximus (Mammalia- Rodentia). PloS one. vol 15. issue 5. 2020-07-31. PMID:32469908. |
we report here our analysis of autophagy (becn1, lamp1 and lc3b-i/ii) and apoptosis (bcl2 and active caspase-3) markers which revealed interactive behaviors between both processes, with autophagy promoting survival or cell death depending on the ovarian structure. |
2020-07-31 |
2023-08-13 |
Not clear |
| Qi Wei, Huan-Yu Zhou, Xiao-Dong Shi, Hong-Yan Cao, Ling Qi. Long Noncoding RNA NEAT1 Promotes Myocardiocyte Apoptosis and Suppresses Proliferation Through Regulation of miR-129-5p. Journal of cardiovascular pharmacology. vol 74. issue 6. 2020-07-27. PMID:31815867. |
collagen deposition and apoptosis were evaluated by western blot detection of collagen and apoptotic proteins, including capase3, bax, and bcl2. |
2020-07-27 |
2023-08-13 |
Not clear |
| Hector Flores-Romero, Olatz Landeta, Begoña Ugarte-Uribe, Katia Cosentino, Miguel García-Porras, Ana J García-Sáez, Gorka Basañe. BFL1 modulates apoptosis at the membrane level through a bifunctional and multimodal mechanism showing key differences with BCLXL. Cell death and differentiation. vol 26. issue 10. 2020-07-24. PMID:30560933. |
by quantitatively analyzing bfl1 action in synthetic membrane models and in cells, we found that bfl1 inhibits apoptosis through three distinct mechanisms which are similar but not identical to those of bclxl, the paradigmatic antiapoptotic bcl2 family protein. |
2020-07-24 |
2023-08-13 |
human |
| Bojie Yang, Quansheng Liu, Yuanhong B. Autophagy and apoptosis are regulated by stress on Bcl2 by AMBRA1 in the endoplasmic reticulum and mitochondria. Theoretical biology & medical modelling. vol 16. issue 1. 2020-07-23. PMID:31665034. |
autophagy and apoptosis are regulated by stress on bcl2 by ambra1 in the endoplasmic reticulum and mitochondria. |
2020-07-23 |
2023-08-13 |
Not clear |
| Hasan Mahmud, Mariana Mendez, Bedabrata Mukhopadhyay, Jennifer Holter-Chakrabarty, Asish K Ghos. HSP90 overexpression potentiates the B-cell receptor and fibroblast growth factor receptor survival signals in chronic lymphocytic leukemia cells. Oncotarget. vol 11. issue 22. 2020-07-19. PMID:32547702. |
finally, hsp90 inhibition induced apoptosis in cll cells in a dose-dependent manner likely via downregulation of anti-apoptotic proteins mcl-1 and xiap, but not bcl2, reported to be overexpressed in cll cells. |
2020-07-19 |
2023-08-13 |
Not clear |
| Xiaoyu Dai, Yangyang Xie, Mingjun Dong, Jianpei Zhao, Hua Yu, Baofeng Zhou, Yidong Xu, Yongming Yu, Yisheng Cao, Youping Zhan. The long noncoding RNA TPTE2P1 promotes the viability of colorectal cancer cells. Journal of cellular biochemistry. vol 120. issue 4. 2020-07-13. PMID:30382596. |
tpte2p1 knockdown also caused cancer cell apoptosis via the activation of the apoptosis regulator (bcl2)/caspase 3 signaling cascade. |
2020-07-13 |
2023-08-13 |
mouse |
| Jong-Tae Kim, Hee Jun Cho, Mi-Young Cho, Jeewon Lim, Eun Sun Park, Jong-Seok Lim, Hee Gu Le. Prenylated Rab acceptor RABAC1 inhibits anti-apoptotic protein BCL2A1 and induces apoptosis. Biochemical and biophysical research communications. vol 513. issue 4. 2020-07-10. PMID:31003775. |
the b cell lymphoma 2 (bcl2) family of proteins constitutes a critical intracellular checkpoint in the intrinsic apoptosis pathway. |
2020-07-10 |
2023-08-13 |
Not clear |