| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ket Hing Chong, Sandhya Samarasinghe, Don Kulasiri, Jie Zhen. Mathematical modelling of core regulatory mechanism in p53 protein that activates apoptotic switch. Journal of theoretical biology. vol 462. 2020-03-23. PMID:30439375. |
building on previous models (chong et al., 2015; zhang et al., 2009a), we developed a mathematical model that incorporated the molecular interactions in the core regulation of p53 and the apoptosis initiation module involving puma, bcl2 and bax. |
2020-03-23 |
2023-08-13 |
Not clear |
| Ket Hing Chong, Sandhya Samarasinghe, Don Kulasiri, Jie Zhen. Mathematical modelling of core regulatory mechanism in p53 protein that activates apoptotic switch. Journal of theoretical biology. vol 462. 2020-03-23. PMID:30439375. |
our simulation results are qualitatively consistent with the experimental findings of all-or-none activation of apoptosis and predicted overexpression of bcl2 as a factor in causing malfunction of the apoptotic switch. |
2020-03-23 |
2023-08-13 |
Not clear |
| P Cao, Y Feng, M Deng, J Li, H Cai, Q Meng, W Fang, Y Li, J Ke, X Lon. MiR-15b is a key regulator of proliferation and apoptosis of chondrocytes from patients with condylar hyperplasia by targeting IGF1, IGF1R and BCL2. Osteoarthritis and cartilage. vol 27. issue 2. 2020-03-23. PMID:30521861. |
mir-15b is a key regulator of proliferation and apoptosis of chondrocytes from patients with condylar hyperplasia by targeting igf1, igf1r and bcl2. |
2020-03-23 |
2023-08-13 |
Not clear |
| Chidimma Agatha Akpa, Karsten Kleo, Dido Lenze, Elisabeth Oker, Lora Dimitrova, Michael Humme. DZNep-mediated apoptosis in B-cell lymphoma is independent of the lymphoma type, EZH2 mutation status and MYC, BCL2 or BCL6 translocations. PloS one. vol 14. issue 8. 2020-03-23. PMID:31419226. |
dznep-mediated apoptosis in b-cell lymphoma is independent of the lymphoma type, ezh2 mutation status and myc, bcl2 or bcl6 translocations. |
2020-03-23 |
2023-08-13 |
Not clear |
| Chidimma Agatha Akpa, Karsten Kleo, Dido Lenze, Elisabeth Oker, Lora Dimitrova, Michael Humme. DZNep-mediated apoptosis in B-cell lymphoma is independent of the lymphoma type, EZH2 mutation status and MYC, BCL2 or BCL6 translocations. PloS one. vol 14. issue 8. 2020-03-23. PMID:31419226. |
we aimed to address the impact of the lymphoma type, ezh2 mutation status, as well as myc, bcl2 and bcl6 translocations on the sensitivity of the lymphoma cell lines to dznep-mediated apoptosis. |
2020-03-23 |
2023-08-13 |
Not clear |
| Chidimma Agatha Akpa, Karsten Kleo, Dido Lenze, Elisabeth Oker, Lora Dimitrova, Michael Humme. DZNep-mediated apoptosis in B-cell lymphoma is independent of the lymphoma type, EZH2 mutation status and MYC, BCL2 or BCL6 translocations. PloS one. vol 14. issue 8. 2020-03-23. PMID:31419226. |
we show that dznep inhibits proliferation and induces apoptosis of these cell lines independent of the type of lymphoma, the ezh2 mutation status and the myc, bcl2 and bcl6 rearrangement status. |
2020-03-23 |
2023-08-13 |
Not clear |
| Chidimma Agatha Akpa, Karsten Kleo, Dido Lenze, Elisabeth Oker, Lora Dimitrova, Michael Humme. DZNep-mediated apoptosis in B-cell lymphoma is independent of the lymphoma type, EZH2 mutation status and MYC, BCL2 or BCL6 translocations. PloS one. vol 14. issue 8. 2020-03-23. PMID:31419226. |
although ezh2, myc, bcl2 and bcl6 are important prognostic biomarkers for lymphomas, our study shows that they poorly influence the sensitivity of lymphoma cell lines to dznep-mediated apoptosis. |
2020-03-23 |
2023-08-13 |
Not clear |
| Jun Lu, Nina Zhou, Ping Yang, Lanqiuzi Deng, Ganzhe Li. MicroRNA-27a-3p Downregulation Inhibits Inflammatory Response and Hippocampal Neuronal Cell Apoptosis by Upregulating Mitogen-Activated Protein Kinase 4 (MAP2K4) Expression in Epilepsy: In Vivo and In Vitro Studies. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2020-03-23. PMID:31710596. |
mir-27a-3p inhibitor also inhibited apoptosis of hippocampal neurons in epileptic rats, promoted bcl2 expression, and decreased bax and caspase3 expression. |
2020-03-23 |
2023-08-13 |
rat |
| Xiao-Mian Lin, Song Li, Chao Zhou, Rong-Zhen Li, Heng Wang, Wu Luo, Yi-Shan Huang, Lian-Kuai Chen, Jia-Long Cai, Tian-Xiang Wang, Qi-Hao Zhang, Hong Cao, Xiao-Ping W. Cisplatin induces chemoresistance through the PTGS2-mediated anti-apoptosis in gastric cancer. The international journal of biochemistry & cell biology. vol 116. 2020-03-20. PMID:31518663. |
in addition, ptgs2 mediated cisplatin-induced bcl2 expression and subsequent resistance to apoptosis via pge2/ep4/mapks (erk1/2, p38) axis. |
2020-03-20 |
2023-08-13 |
human |
| Esmail Nourmohammadi, Hoda Khoshdel-Sarkarizi, Reza Nedaeinia, Hamid Reza Sadeghnia, Leila Hasanzadeh, Majid Darroudi, Reza Kazemi Oskue. Evaluation of anticancer effects of cerium oxide nanoparticles on mouse fibrosarcoma cell line. Journal of cellular physiology. vol 234. issue 4. 2020-03-18. PMID:30187476. |
for apoptosis assay, the annexin v/pi test was done as well as measuring the mrna and protein expression levels of bax and bcl2 by real-time pcr and western blot method, respectively. |
2020-03-18 |
2023-08-13 |
mouse |
| Souvik Roy, Anweshan Sil, Tania Chakrabort. Potentiating apoptosis and modulation of p53, Bcl2, and Bax by a novel chrysin ruthenium complex for effective chemotherapeutic efficacy against breast cancer. Journal of cellular physiology. vol 234. issue 4. 2020-03-18. PMID:30246261. |
potentiating apoptosis and modulation of p53, bcl2, and bax by a novel chrysin ruthenium complex for effective chemotherapeutic efficacy against breast cancer. |
2020-03-18 |
2023-08-13 |
human |
| Zhenlong Kang, Na Qiao, Gaoyang Liu, Hanming Chen, Zhaoxin Tang, Ying L. Copper-induced apoptosis and autophagy through oxidative stress-mediated mitochondrial dysfunction in male germ cells. Toxicology in vitro : an international journal published in association with BIBRA. vol 61. 2020-03-18. PMID:31491480. |
copper also down-regulated bcl2 and up-regulated bax, casp8 and casp3 linking the effects of copper to increased apoptosis. |
2020-03-18 |
2023-08-13 |
cat |
| Parvaneh Mehrbod, Sudharsana R Ande, Javad Alizadeh, Shahrzad Rahimizadeh, Aryana Shariati, Hadis Malek, Mohammad Hashemi, Kathleen K M Glover, Affan A Sher, Kevin M Coombs, Saeid Ghavam. The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections. Virulence. vol 10. issue 1. 2020-03-05. PMID:30966844. |
both autophagy and upr are connected to programed cell death i (apoptosis) in chronic stress conditions to regulate cellular homeostasis via bcl2 family proteins, chop and beclin-1. |
2020-03-05 |
2023-08-13 |
mouse |
| Xu Luo, Bo Lin, Youguang Gao, Xianghui Lei, Xiang Wang, Yunfeng Li, Tao L. Genipin attenuates mitochondrial-dependent apoptosis, endoplasmic reticulum stress, and inflammation via the PI3K/AKT pathway in acute lung injury. International immunopharmacology. vol 76. 2020-03-03. PMID:31466050. |
in addition, genipin pretreatment attenuated lps-mediated mitochondrial apoptosis, as indicated by improved mitochondrial dysfunction, downregulation of bax (bcl2 associated x, apoptosis regulator), upregulation of bcl2 (bcl2 apoptosis regulator), inhibited the release of cytochrome c, activation of caspase-3, and cell apoptosis. |
2020-03-03 |
2023-08-13 |
Not clear |
| Bhavesh K Ahir, Sajani S Lakk. Elucidating the microRNA-203 specific biological processes in glioblastoma cells from comprehensive RNA-sequencing transcriptome profiling. Cellular signalling. vol 53. 2020-02-26. PMID:30244172. |
after go enrichment, the downregulated differentially expressed genes such as bcl2, sparc were found to be mainly enriched in cell cycle regulation and apoptosis processes, whereas the upregulated differentially expressed genes such as ccnd1, e2f1 were involved in the dna replication and cell cycle regulation. |
2020-02-26 |
2023-08-13 |
Not clear |
| Gaowu Hu, Huajiang Liu, Ming Wang, Wei Pen. IQ Motif Containing GTPase-Activating Protein 3 (IQGAP3) Inhibits Kaempferol-Induced Apoptosis in Breast Cancer Cells by Extracellular Signal-Regulated Kinases 1/2 (ERK1/2) Signaling Activation. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2020-02-20. PMID:31605603. |
upregulation of iqgap3 inhibited apoptosis in bc cells, along with increased expression of phosphorylated extracellular signal-regulated kinases 1/2 (p-erk1/2) and b cell lymphoma 2 (bcl2) and decreased bcl-2-associated x protein (bax) expression, which was counteracted by kaempferol treatment. |
2020-02-20 |
2023-08-13 |
Not clear |
| Bo Li, Junkai Zhang, Ya Su, Yiling Hou, Zhenguo Wang, Lin Zhao, Shengkai Sun, Hao F. Overexpression of PTEN may increase the effect of pemetrexed on A549 cells via inhibition of the PI3K/AKT/mTOR pathway and carbohydrate metabolism. Molecular medicine reports. vol 20. issue 4. 2020-02-19. PMID:31485626. |
result from the present study demonstrated that treatment with pemetrexed suppressed lung cancer cell proliferation, inhibited mrna and protein expression levels of anti‑apoptotic bcl2, and increased the mrna and the protein expression levels of pro‑apoptotic p53 and apoptosis regulator bax. |
2020-02-19 |
2023-08-13 |
Not clear |
| Debottam Sinha, Pascal H G Duijf, Kum Kum Khann. Mitotic slippage: an old tale with a new twist. Cell cycle (Georgetown, Tex.). vol 18. issue 1. 2020-02-17. PMID:30601084. |
abbreviations: apc/c: anaphase-promoting complex/cyclosome; bad: bcl2-associated agonist of cell death; bak1: bcl2 antagonist kinase1; bax: bcl2-associated x; bcl2: b-cell chronic lymphocytic leukaemia (cll)/lymphoma 2; bh: bcl2 homology domain; bid: bh3-interacting domain death agonist; bim: bcl2-interacting mediator of cell death; bub: budding uninhibited by benzimidazoles; cdc: cell division cycle; cdh1: cadherin-1; cdk1: cyclin-dependent kinase 1; cep55: centrosomal protein (55 kda): cin: chromosomal instability; cta: cancer testis antigen; egr1: early growth response protein 1; erk: extracellular signal-regulated kinase; escrt: endosomal sorting complexes required for transport; gin: genomic instability; mad2: mitotic arrest deficient 2; mcl1: myeloid cell leukemia sequence 1; mps1: monopolar spindle 1 kinase; myt1: myelin transcription factor 1; plk1: polo like kinase 1; puma: p53-upregulated mediator of apoptosis; sac: spindle assembly checkpoint; taa: tumor-associated antigen. |
2020-02-17 |
2023-08-13 |
Not clear |
| Priyanka Upadhyay, Sushmita Sarker, Avijit Ghosh, Payal Gupta, Shaswati Das, Manisha Ahir, Saurav Bhattacharya, Sreya Chattopadhyay, Swatilekha Ghosh, Arghya Adhikar. Transferrin-decorated thymoquinone-loaded PEG-PLGA nanoparticles exhibit anticarcinogenic effect in non-small cell lung carcinoma via the modulation of miR-34a and miR-16. Biomaterials science. vol 7. issue 10. 2020-02-10. PMID:31411213. |
tf-tq-np-mediated p53 up-regulation favored the potential simultaneous activation of mir-34a and mir-16 targeting bcl2 to induce apoptosis in the a549 cells. |
2020-02-10 |
2023-08-13 |
mouse |
| Tomoko Takimoto-Shimomura, Taku Tsukamoto, Saori Maegawa, Yuto Fujibayashi, Yayoi Matsumura-Kimoto, Yoshimi Mizuno, Yoshiaki Chinen, Yuji Shimura, Shinsuke Mizutani, Shigeo Horiike, Masafumi Taniwaki, Tsutomu Kobayashi, Junya Kurod. Dual targeting of bromodomain-containing 4 by AZD5153 and BCL2 by AZD4320 against B-cell lymphomas concomitantly overexpressing c-MYC and BCL2. Investigational new drugs. vol 37. issue 2. 2020-02-05. PMID:29931583. |
to augment cell death induction, we added a novel bh3-mimicking bcl2 inhibitor azd4320 to azd5153, and found that these two agents had a mostly synergistic antitumor effect by increasing cells undergoing apoptosis in all three cell lines. |
2020-02-05 |
2023-08-13 |
Not clear |