| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Deliang Cheng, Jiageng Li, Lijun Zhang, Leiming H. miR-142-5p suppresses proliferation and promotes apoptosis of human osteosarcoma cell line, HOS, by targeting PLA2G16 through the ERK1/2 signaling pathway. Oncology letters. vol 17. issue 1. 2020-09-30. PMID:30655907. |
western blot analysis indicated that mir-142-5p transfection reduced bcl2, apoptosis regulator expression and upregulated the expression of casp3 and bcl2 associated x, apoptosis regulator in hos cells. |
2020-09-30 |
2023-08-13 |
human |
| Jia-Wen Shou, Chun-Kai Cheung, Jian Gao, Wei-Wei Shi, Pang-Chui Sha. Berberine Protects C17.2 Neural Stem Cells From Oxidative Damage Followed by Inducing Neuronal Differentiation. Frontiers in cellular neuroscience. vol 13. 2020-09-30. PMID:31551713. |
it also down-regulated the apoptotic factors-caspase 3 and bcl2 associated x (bax) and upregulated the anti-apoptotic factor-bcl2 to reduce cell apoptosis. |
2020-09-30 |
2023-08-13 |
Not clear |
| Daoud Ali, Abhilasha Tripathi, Hussain Al Ali, Yadvendra Shahi, Kamlesh K Mishra, Saud Alarifi, Abdullah A Alkahtane, Salem Manoharda. ROS-dependent Bax/Bcl2 and caspase 3 pathway-mediated apoptosis induced by zineb in human keratinocyte cells. OncoTargets and therapy. vol 11. 2020-09-29. PMID:29416349. |
zineb increased levels of bax and caspase 3 and inhibited the level of bcl2, which subsequently induced apoptosis via the bax/bcl2 and caspase pathway. |
2020-09-29 |
2023-08-13 |
human |
| Xiaoxiao Qian, Juan Tan, Ling Liu, Sheng Chen, Na You, Huijuan Yong, Minglin Pan, Qiang You, Dafa Ding, Yibing L. MicroRNA-134-5p promotes high glucose-induced podocyte apoptosis by targeting bcl-2. American journal of translational research. vol 10. issue 3. 2020-09-29. PMID:29636888. |
finally, we found that mir-134-5p might regulate apoptosis in db/db mice and podocytes by targeting bcl2. |
2020-09-29 |
2023-08-13 |
mouse |
| Xiaoxiao Qian, Juan Tan, Ling Liu, Sheng Chen, Na You, Huijuan Yong, Minglin Pan, Qiang You, Dafa Ding, Yibing L. MicroRNA-134-5p promotes high glucose-induced podocyte apoptosis by targeting bcl-2. American journal of translational research. vol 10. issue 3. 2020-09-29. PMID:29636888. |
taken together, our findings suggest that mir-134-5p promotes podocyte apoptosis under hg conditions by targeting bcl2. |
2020-09-29 |
2023-08-13 |
mouse |
| Hong Gao, Hai Dong, Guijun Li, Hui Ji. Combined treatment with acetazolamide and cisplatin enhances chemosensitivity in laryngeal carcinoma Hep-2 cells. Oncology letters. vol 15. issue 6. 2020-09-29. PMID:29928333. |
expression levels of apoptosis-related proteins, including bcl2 apoptosis regulator (bcl-2), bcl2 associated x (bax) and caspase-3, and of proliferation-related proteins, including proliferating cell nuclear antigen (pcna) and tumor protein p53 (p53), were detected using western blotting. |
2020-09-29 |
2023-08-13 |
Not clear |
| Seth Morrill, David Z Z H. Apoptosis in inner ear sensory hair cells. Journal of otology. vol 12. issue 4. 2020-09-29. PMID:29937851. |
we will review current literature on the bcl2 and bcl6 protein interactions in relation to apoptosis and their possible roles in vulnerability and survival of cochlear hair cells. |
2020-09-29 |
2023-08-13 |
Not clear |
| Luo Li, Shuangcheng Chen, Yunwei Sun, Lu Kong, Guangping Liu, Pin Gu. Matrine inhibits the proliferation of pituitary tumor cells by decreasing Foxo3a phosphorylation and promoting Foxo3a nuclear localization. Experimental and therapeutic medicine. vol 17. issue 5. 2020-09-29. PMID:30988763. |
matrine increased the nuclear localization of foxo3a and the expression of proapoptotic genes, such as bcl2 like 11 and bcl2 associated x apoptosis regulator, and inhibited the levels of cytoplasmic foxo3a. |
2020-09-29 |
2023-08-13 |
Not clear |
| Lin Sun, Yujie Guo, Peng He, Xiaoyan Xu, Xiong Zhang, Haiyang Wang, Tian Tang, Wei Zhou, Ping Xu, Peng Xi. Genome-wide profiling of long noncoding RNA expression patterns and CeRNA analysis in mouse cortical neurons infected with different strains of borna disease virus. Genes & diseases. vol 6. issue 2. 2020-09-29. PMID:31193942. |
lncrna may be involved in regulation of hu-h1 inhibited cell proliferation and promoted apoptosis through nf-kb, jnk/mapk signaling, bcl2 and cdk6/e2f1 pathways different from strain v. possible interaction networks as ensmust00000128469/mir-22-5p, mir-206-3p, mir-302b-5p, mir-302c-3p, mir-1a-3p/igf1 may involve in regulation of cell proliferation, apoptosis, and cancer. |
2020-09-29 |
2023-08-13 |
mouse |
| Hongwen Cao, Yigeng Feng, Lei Chen, Chao Y. Lobaplatin Inhibits Prostate Cancer Proliferation and Migration Through Regulation of BCL2 and BAX. Dose-response : a publication of International Hormesis Society. vol 17. issue 2. 2020-09-29. PMID:31217754. |
meanwhile, lobaplatin treatment regulates apoptosis by downregulation of bcl2 expression and upregulation of bax expression levels. |
2020-09-29 |
2023-08-13 |
Not clear |
| Mei-Hua Jin, Jia-Bin Yu, Hu-Nan Sun, Ying-Hua Jin, Gui-Nan Shen, Cheng-Hao Jin, Yu-Dong Cui, Dong-Seok Lee, Sun-Uk Kim, Ji-Su Kim, Taeho Kwon, Ying-Hao Ha. Peroxiredoxin II Maintains the Mitochondrial Membrane Potential against Alcohol-Induced Apoptosis in HT22 Cells. Antioxidants (Basel, Switzerland). vol 9. issue 1. 2020-09-28. PMID:31861323. |
the phosphorylation of gsk3β (ser9) and anti-apoptotic protein bcl2 expression levels were significantly downregulated in prx ii knockdown ht22 cells, which suggests that prx ii knockdown ht22 cells were more susceptible to alcohol-induced apoptosis. |
2020-09-28 |
2023-08-13 |
Not clear |
| Yonghong Luo, Chuanchuan Fang, Lan Jin, Huafeng Ding, Yuanyuan Lyu, Guantai N. The microRNA212 regulated PEA15 promotes ovarian cancer progression by inhibiting of apoptosis. Journal of Cancer. vol 11. issue 6. 2020-09-28. PMID:32047549. |
in addition, we proved knockdown of pea15 inhibits oc cell proliferation and induces cell apoptosis by bcl2 downregulation and bax and cleaved caspase-3 upregulation. |
2020-09-28 |
2023-08-13 |
Not clear |
| Jie Zhang, Yiyi Li, Chao Wang, Yaya Wang, Yangyang Zhang, Liqin Huang, Zhaohui Zhan. Lysophosphatidic Acid Induces Apoptosis of PC12 Cells Through LPA1 Receptor/LPA2 Receptor/MAPK Signaling Pathway. Frontiers in molecular neuroscience. vol 13. 2020-09-28. PMID:32116549. |
lpa elicits the activation of erk1/2, p38, and jnk pathways, decreases the expression of bcl2, promotes the translocation of bax, and enhances the activation of caspase-3, resulting in mitochondrial dysfunction and cell apoptosis. |
2020-09-28 |
2023-08-13 |
Not clear |
| Xuefeng Jiang, Yusheng Liu, Guijuan Zhang, Shujun Lin, Jieyan Wu, Xianxin Yan, Yi Ma, Min M. Aloe-Emodin Induces Breast Tumor Cell Apoptosis through Upregulation of miR-15a/miR-16-1 That Suppresses BCL2. Evidence-based complementary and alternative medicine : eCAM. vol 2020. 2020-09-28. PMID:32190086. |
aloe-emodin induces breast tumor cell apoptosis through upregulation of mir-15a/mir-16-1 that suppresses bcl2. |
2020-09-28 |
2023-08-13 |
Not clear |
| Bibo Yuan, Juan Hao, Qian Zhang, Yan Wang, Yu Zh. Role of Bcl-2 on drug resistance in breast cancer polyploidy-induced spindle poisons. Oncology letters. vol 19. issue 3. 2020-09-28. PMID:32194662. |
the expression of f-box and wd repeat domain containing 7 (fbw7) was decreased, while the expression of mcl1 apoptosis regulator bcl2 family member (mcl-1) and bcl-2 was increased, and caspase-3/9 and bax were not expressed in mda-mb-231 cells. |
2020-09-28 |
2023-08-13 |
Not clear |
| Chawalit Chatupheeraphat, Chanin Nantasenamat, Kamolchanok Deesrisak, Sittiruk Roytrakul, Usanarat Anurathapan, Dalina Tanyon. Bioinformatics and experimental studies of anti-leukemic activity from 6-gingerol demonstrate its role in p53 mediated apoptosis pathway. EXCLI journal. vol 19. 2020-09-28. PMID:32483405. |
in addition, p53, bax and bcl2 could be involved in the apoptosis pathway of these leukemic cells. |
2020-09-28 |
2023-08-13 |
Not clear |
| Sanjay Kumar, Paul B Tchounwo. Trisenox Disrupts MDM2-DAXX-HAUSP Complex and Induces Apoptosis in a Mouse Model of Acute Leukemia. Journal of Cancer. vol 11. issue 15. 2020-09-28. PMID:32489456. |
it also caused apoptosis through upregulation of caspase 3 and bax expression, and down-regulation of bcl2 expression. |
2020-09-28 |
2023-08-13 |
mouse |
| Kaili Ma, Guo Chen, Wenhui Li, Oliver Kepp, Yushan Zhu, Quan Che. Mitophagy, Mitochondrial Homeostasis, and Cell Fate. Frontiers in cell and developmental biology. vol 8. 2020-09-28. PMID:32671064. |
bcl2 family proteins interact within family members to regulate mitochondrial outer membrane permeabilization and apoptosis. |
2020-09-28 |
2023-08-13 |
Not clear |
| Fatemeh Taherkhani, Kamran Mousavi Hosseini, Sanaz Zebardast, Koorosh Goodarzvand Chegini, Nematollah Gheib. Anti proliferative and apoptotic effects on pancreatic cancer cell lines indicate new roles for ANGPTL8 (Betatrophin). Genetics and molecular biology. vol 43. issue 3. 2020-09-28. PMID:32745158. |
moreover, the induction of apoptosis by angptl8 occurred by the down-regulation of bcl2. |
2020-09-28 |
2023-08-13 |
Not clear |
| Jiarui Yu, Wei Wang, Weinan Yao, Zhao Yang, Peng Gao, Meiyue Liu, Huan Wang, Siyuan Chen, Dan Wang, Weixi Wang, Guogui Su. Gambogic acid affects ESCC progression through regulation of PI3K/AKT/mTOR signal pathway. Journal of Cancer. vol 11. issue 19. 2020-09-28. PMID:32913452. |
meanwhile, ga induced dose-dependent apoptosis of escc cells, repressed the expression of bcl2 and up-regulated the levels of bax protein, cleaved-parp1 and cleaved-caspase 3/9. |
2020-09-28 |
2023-08-13 |
Not clear |