| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ai Jin, Rujuan Bao, Michael Roth, Li Liu, Xudong Yang, Xuemei Tang, Xiaojun Yang, Qingzhu Sun, Shemin L. microRNA-23a contributes to asthma by targeting BCL2 in airway epithelial cells and CXCL12 in fibroblasts. Journal of cellular physiology. vol 234. issue 11. 2020-06-01. PMID:31020662. |
moreover, in epithelial cells, interleukin-4 upregulated mir-23a expression and thereby decreased the expression of bcl2, while increasing the caspase-3 expression, which was followed by apoptosis. |
2020-06-01 |
2023-08-13 |
rat |
| Guo Chen, Dongkyoo Park, Andrew T Magis, Madhusmita Behera, Suresh S Ramalingam, Taofeek K Owonikoko, Gabriel L Sica, Keqiang Ye, Chao Zhang, Zhengjia Chen, Walter J Curran, Xingming Den. Mcl-1 Interacts with Akt to Promote Lung Cancer Progression. Cancer research. vol 79. issue 24. 2020-05-27. PMID:31662324. |
mcl-1 is a unique antiapoptotic bcl2 family protein that functions as a gatekeeper in manipulating apoptosis and survival in cancer cells. |
2020-05-27 |
2023-08-13 |
human |
| Anran Xu, Jianye Wang, Haiyu Wang, Yanqing Sun, Tianyu Ha. Protective effect of lycopene on testicular toxicity induced by Benzo[a]pyrene intake in rats. Toxicology. vol 427. 2020-05-19. PMID:31568845. |
besides, lyc ameliorated bap-mediated gap-junction dysfunction of sertoli cells, as shown by the inhibited sertoli cell death and apoptosis, the upregulation of bcl2 and cx43, the downregulation of cleaved caspase 3, bax and cam, and the decrease in ca |
2020-05-19 |
2023-08-13 |
rat |
| Karen E Weis, Lori T Raetzma. Genistein inhibits proliferation and induces senescence in neonatal mouse pituitary gland explant cultures. Toxicology. vol 427. 2020-05-19. PMID:31593742. |
we also found that 36 μm genistein decreased bcl2 mrna levels, a gene protective against apoptosis. |
2020-05-19 |
2023-08-13 |
mouse |
| Maryam Vahdat-Lasemi, Sara Hosseini, Vahid Jajarmi, Bahram Kazemi, Mohammad Saleh. Intraovarian injection of miR-224 as a marker of polycystic ovarian syndrome declines oocyte competency and embryo development. Journal of cellular physiology. vol 234. issue 8. 2020-05-18. PMID:30605234. |
because patients with pcos have decreased numbers of follicular cells related to cell apoptosis, we also investigated two apoptotic genes, bax and bcl2. |
2020-05-18 |
2023-08-13 |
mouse |
| Maryam Vahdat-Lasemi, Sara Hosseini, Vahid Jajarmi, Bahram Kazemi, Mohammad Saleh. Intraovarian injection of miR-224 as a marker of polycystic ovarian syndrome declines oocyte competency and embryo development. Journal of cellular physiology. vol 234. issue 8. 2020-05-18. PMID:30605234. |
the changes in bcl2 and bax expression levels, as apoptosis biomarkers, showed that apoptosis was a secondary outcome of the effect of mir-224. |
2020-05-18 |
2023-08-13 |
mouse |
| He Ding, Jing Zhao, Hongyu Liu, Jun Wang, Wenfa L. BMAL1 knockdown promoted apoptosis and reduced testosterone secretion in TM3 Leydig cell line. Gene. vol 747. 2020-05-18. PMID:32305634. |
results showed that bmal1 knockdown promoted the apoptosis of leydig cells and expression of (bcl2 associated x) bax mrna and protein, and reduced the expression of (b-cell lymphoma-2) bcl-2 mrna and protein. |
2020-05-18 |
2023-08-13 |
mouse |
| Jiao Chen, Yi Gong, Huaiping Zheng, Hongyu Ma, Jude Juventus Aweya, Yueling Zhang, Xinghan Chen, Sheng-Kang L. SpBcl2 promotes WSSV infection by suppressing apoptotic activity of hemocytes in mud crab, Scylla paramamosain. Developmental and comparative immunology. vol 100. 2020-05-11. PMID:31254562. |
the bcl2 protein plays a key role in the mitochondrial apoptosis pathway, which is a crucial immune response in invertebrates. |
2020-05-11 |
2023-08-13 |
Not clear |
| Jiao Chen, Yi Gong, Huaiping Zheng, Hongyu Ma, Jude Juventus Aweya, Yueling Zhang, Xinghan Chen, Sheng-Kang L. SpBcl2 promotes WSSV infection by suppressing apoptotic activity of hemocytes in mud crab, Scylla paramamosain. Developmental and comparative immunology. vol 100. 2020-05-11. PMID:31254562. |
however, the role of bcl2 in apoptosis and immunoregulation in mud crab, scylla paramamosain, is poorly understood. |
2020-05-11 |
2023-08-13 |
Not clear |
| Sara Cheleschi, Sara Tenti, Nicola Mondanelli, Claudio Corallo, Marcella Barbarino, Stefano Giannotti, Ines Gallo, Antonio Giordano, Antonella Fioravant. MicroRNA-34a and MicroRNA-181a Mediate Visfatin-Induced Apoptosis and Oxidative Stress via NF-κB Pathway in Human Osteoarthritic Chondrocytes. Cells. vol 8. issue 8. 2020-05-11. PMID:31405216. |
visfatin significantly induced apoptosis and superoxide anion production, increased mir-34a, mir-181a, superoxide dismutase (sod)-2, catalase (cat), nrf2 and decreased bcl2 gene and protein expression in oa chondrocytes. |
2020-05-11 |
2023-08-13 |
human |
| Juan Bautista Menendez-Gonzalez, Milica Vukovic, Ali Abdelfattah, Lubaid Saleh, Alhomidi Almotiri, Leigh-Anne Thomas, Aloña Agirre-Lizaso, Aleksandra Azevedo, Ana Catarina Menezes, Giusy Tornillo, Sarah Edkins, Kay Kong, Peter Giles, Fernando Anjos-Afonso, Alex Tonks, Ashleigh S Boyd, Kamil R Kranc, Neil P Rodrigue. Gata2 as a Crucial Regulator of Stem Cells in Adult Hematopoiesis and Acute Myeloid Leukemia. Stem cell reports. vol 13. issue 2. 2020-04-23. PMID:31378673. |
ablation of gata2 enforces an lsc-specific program of enhanced apoptosis, exemplified by attenuation of anti-apoptotic factor bcl2, and re-instigation of myeloid differentiation--which is characteristically blocked in aml. |
2020-04-23 |
2023-08-13 |
mouse |
| Thu Ha Pham, Lohann Derian, Christine Kervarrec, Pierre-Yves Kernanec, Bernard Jégou, Fatima Smagulova, Aurore Gely-Perno. Perinatal Exposure to Glyphosate and a Glyphosate-Based Herbicide Affect Spermatogenesis in Mice. Toxicological sciences : an official journal of the Society of Toxicology. vol 169. issue 1. 2020-04-20. PMID:30785197. |
moreover, the undifferentiated spermatogonia numbers were decreased by 60% in 5 mg/kg/day glyphosate group, which could be due to the alterations in the expression of genes involved in germ cell differentiation such as sall4 and nano3 and apoptosis as bax and bcl2. |
2020-04-20 |
2023-08-13 |
mouse |
| Zhen Cheng, Weiwei Sun, Xiaohui Ni, Hua Xu, Youhua Wan. GAB2 inhibits chondrocyte apoptosis through PI3K-AKT signaling in osteoarthritis. International journal of clinical and experimental pathology. vol 13. issue 3. 2020-04-11. PMID:32269703. |
moreover, gab2 knockdown inhibited akt phosphorylation, increased bax expression, and decreased bcl2 expression, which indicated that gab2 regulates chondrocyte apoptosis through pi3k-akt signaling. |
2020-04-11 |
2023-08-13 |
Not clear |
| Chao He, Chao Liu, Lei Wang, Yangbai Sun, Yuhang Jiang, Yongqiang Ha. Histone methyltransferase NSD2 regulates apoptosis and chemosensitivity in osteosarcoma. Cell death & disease. vol 10. issue 2. 2020-04-06. PMID:30683853. |
the results of chromatin immunoprecipitation quantitative polymerase chain reaction (chip-qpcr) assays indicated that nsd2 knockdown leads to decreased h3k36me2 modification at bcl2 and sox2 loci, thus inhibiting the transcription of these two genes that are closely correlated with apoptosis, csc properties and chemosensitivity in os cells. |
2020-04-06 |
2023-08-13 |
Not clear |
| Chao He, Chao Liu, Lei Wang, Yangbai Sun, Yuhang Jiang, Yongqiang Ha. Histone methyltransferase NSD2 regulates apoptosis and chemosensitivity in osteosarcoma. Cell death & disease. vol 10. issue 2. 2020-04-06. PMID:30683853. |
nsd2 regulates the expression of the apoptosis regulatory proteins bcl2 and sox2 through the erk and akt pathways. |
2020-04-06 |
2023-08-13 |
Not clear |
| Wenhui Zhou, Huan Fang, Qiuju Wu, Xinye Wang, Rong Liu, Fubin Li, Ji Xiao, Lin Yuan, Zhongmei Zhou, Junying Ma, Lulu Wang, Weiwei Zhao, Hua You, Jianhua Ju, Jing Feng, Ceshi Che. Ilamycin E, a natural product of marine actinomycete, inhibits triple-negative breast cancer partially through ER stress-CHOP-Bcl-2. International journal of biological sciences. vol 15. issue 8. 2020-04-06. PMID:31360114. |
depletion of chop or overexpression of bcl2 significantly rescued ilamycin e-induced apoptosis. |
2020-04-06 |
2023-08-13 |
Not clear |
| S L Xie, M Wang, X H Du, Z W Zhao, G Y L. [miR-455 Inhibits HepG2 Cell Proliferation and Promotes Apoptosis by Targeting RhoC]. Molekuliarnaia biologiia. vol 54. issue 1. 2020-04-06. PMID:32163390. |
as pten is a key tumor suppressor gene in hcc, and bcl-2 and caspase 3 are important indication of apoptosis, expression levels of pten, bcl2 and caspase 3 proteins were determined in cells overexpressing rhoc. |
2020-04-06 |
2023-08-13 |
Not clear |
| S L Xie, M Wang, X H Du, Z W Zhao, G Y L. [miR-455 Inhibits HepG2 Cell Proliferation and Promotes Apoptosis by Targeting RhoC]. Molekuliarnaia biologiia. vol 54. issue 1. 2020-04-06. PMID:32163390. |
in addition, we show that rhoc could activate the hcc cells proliferation ability and inhibit apoptosis rate (p < 0.01), and decrease expression of pten and caspase 3 (p < 0.01), while upregulating levels of bcl2. |
2020-04-06 |
2023-08-13 |
Not clear |
| Bruce Weder, Céline Mamie, Gerhard Rogler, Stephen Clarke, Bradford McRae, Pedro A Ruiz, Martin Hausman. BCL2 Regulates Differentiation of Intestinal Fibroblasts. Inflammatory bowel diseases. vol 24. issue 9. 2020-03-30. PMID:29796658. |
activation of fibroblasts is linked to the b-cell lymphoma 2 (bcl2) family, which is involved in the induction of apoptosis. |
2020-03-30 |
2023-08-13 |
Not clear |
| Didar Yanardag Acik, Mehmet Bankir, Filiz Alkan Baylan, Bilal Aygu. Can ELABELA be a novel target in the treatment of chronic lymphocytic leukaemia? BMC cancer. vol 19. issue 1. 2020-03-30. PMID:31718601. |
it has been shown that bcl2, bcl-xl and mcl-1 protein levels are high in chronic lymphocytic leukemia cells, and resultantly, apoptosis does not occur chronic lymphocytic leukemia cells. |
2020-03-30 |
2023-08-13 |
human |