| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Varuna Nangia, Faria M Siddiqui, Sean Caenepeel, Daria Timonina, Samantha J Bilton, Nicole Phan, Maria Gomez-Caraballo, Hannah L Archibald, Chendi Li, Cameron Fraser, Diamanda Rigas, Kristof Vajda, Lorin A Ferris, Michael Lanuti, Cameron D Wright, Kevin A Raskin, Daniel P Cahill, John H Shin, Colleen Keyes, Lecia V Sequist, Zofia Piotrowska, Anna F Farago, Christopher G Azzoli, Justin F Gainor, Kristopher A Sarosiek, Sean P Brown, Angela Coxon, Cyril H Benes, Paul E Hughes, Aaron N Hat. Exploiting MCL1 Dependency with Combination MEK + MCL1 Inhibitors Leads to Induction of Apoptosis and Tumor Regression in Cancer discovery. vol 8. issue 12. 2019-12-23. PMID:30254092. |
exploiting mcl1 dependency with combination mek + mcl1 inhibitors leads to induction of apoptosis and tumor regression in bh3 mimetic drugs, which inhibit prosurvival bcl2 family proteins, have limited single-agent activity in solid tumor models. |
2019-12-23 |
2023-08-13 |
Not clear |
| De-Zhe Chen, Wei-Wei Wang, Yan-Ling Chen, Xia-Feng Yang, Min Zhao, Yan-Yan Yan. miR‑128 is upregulated in epilepsy and promotes apoptosis through the SIRT1 cascade. International journal of molecular medicine. vol 44. issue 2. 2019-12-23. PMID:31173166. |
subsequently, results from an in vitro epilepsy model demonstrated that overexpression of mir‑128 promoted nerve cell apoptosis, increased the protein expression of tumor protein p53, bcl2 associated x (bax) and cytochrome c, and enhanced caspase‑3/9 activity, whereas it suppressed the protein expression of sirtuin 1 (sirt1). |
2019-12-23 |
2023-08-13 |
rat |
| Ganiou Assani, Akadiri Yessoufou, Yudi Xiong, Julien Segbo, Xiaoyuan Yu, Fuxiang Zhou, Yunfeng Zho. Role of TMPRSS4 Modulation in Breast Cancer Cell Proliferation. Asian Pacific journal of cancer prevention : APJCP. vol 20. issue 6. 2019-12-18. PMID:31244309. |
moreover, western blot was used to detect the expression of certain proteinsrelated to cell apoptosis (bax and bcl2) signaling pathway and telomere maintenance (pot1, tpp1, and ube2d3).cell cycle and cell apoptosis were also analyzed by using the flow cytometry analysis. |
2019-12-18 |
2023-08-13 |
Not clear |
| Milad Zadi Heydarabad, Mousa Vatanmakanian, Jalal Abdolalizadeh, Hamed Mohammadi, Ako Azimi, Reza Mousavi Ardehaie, Aliakbar Movasaghpour, Majid Farshdousti Hag. Apoptotic effect of resveratrol on human T-ALL cell line CCRF-CEM is unlikely exerted through alteration of BAX and BCL2 promoter methylation. Journal of cellular biochemistry. vol 119. issue 12. 2019-12-17. PMID:30132966. |
based on our previous study, the resveratrol treatment can trigger apoptosis in ccrf-cem cell line via upregulation of apoptotic bax gene and downregulation of antiapoptotic bcl2 gene. |
2019-12-17 |
2023-08-13 |
human |
| Wenbo Yang, Yanxin Han, Chendie Yang, Yanjia Chen, Weilin Zhao, Xiuxiu Su, Ke Yang, Wei Ji. MicroRNA-19b-1 reverses ischaemia-induced heart failure by inhibiting cardiomyocyte apoptosis and targeting Bcl2 l11/BIM. Heart and vessels. vol 34. issue 7. 2019-12-17. PMID:30607541. |
microrna-19b-1 reverses ischaemia-induced heart failure by inhibiting cardiomyocyte apoptosis and targeting bcl2 l11/bim. |
2019-12-17 |
2023-08-13 |
Not clear |
| Manisit Das, Limei Shen, Qi Liu, Tyler J Goodwin, Leaf Huan. Nanoparticle Delivery of RIG-I Agonist Enables Effective and Safe Adjuvant Therapy in Pancreatic Cancer. Molecular therapy : the journal of the American Society of Gene Therapy. vol 27. issue 3. 2019-12-16. PMID:30545600. |
retinoic acid-inducible gene i (rig-i)-like receptors can bind to 5' triphosphate dsrna (ppp dsrna), a pathogen-associated molecular pattern, producing type i interferon, while bcl2 silencing can drive apoptosis of cancer cells. |
2019-12-16 |
2023-08-13 |
Not clear |
| Joshua Z Drago, Sarat Chandarlapaty, Komal Jhaver. Targeting Apoptosis: A New Paradigm for the Treatment of Estrogen Receptor-Positive Breast Cancer. Cancer discovery. vol 9. issue 3. 2019-12-10. PMID:30824486. |
in this issue, lok and colleagues diverge from this paradigm by combining the bcl2 inhibitor venetoclax with tamoxifen in a phase ib clinical trial, building on preclinical work to demonstrate that targeting apoptosis could represent a promising new strategy in the treatment of breast cancer. |
2019-12-10 |
2023-08-13 |
Not clear |
| L Yu, G-Q Zhou, D-C L. MiR-136 triggers apoptosis in human gastric cancer cells by targeting AEG-1 and BCL2. European review for medical and pharmacological sciences. vol 22. issue 21. 2019-12-06. PMID:30468468. |
mir-136 triggers apoptosis in human gastric cancer cells by targeting aeg-1 and bcl2. |
2019-12-06 |
2023-08-13 |
human |
| Ming Tan, Mohammad Asad, Valerie Heong, Meng Kang Wong, Tuan Zea Tan, Jieru Ye, Kuee Theng Kuay, Jean Paul Thiery, Clare Scott, Ruby Yun-Ju Huan. The FZD7-TWIST1 axis is responsible for anoikis resistance and tumorigenesis in ovarian carcinoma. Molecular oncology. vol 13. issue 4. 2019-12-02. PMID:30548372. |
we also identified that the fzd7-twist1 axis regulates the expression of bcl2, a gene that controls apoptosis. |
2019-12-02 |
2023-08-13 |
Not clear |
| S M Zaki, Wa Abd Algaleel, R A Imam, M M Abdelmoat. Mesenchymal stem cells pretreated with platelet-rich plasma modulate doxorubicin-induced cardiotoxicity. Human & experimental toxicology. vol 38. issue 7. 2019-12-02. PMID:30991846. |
the major factors in the dox-induced cardiotoxicity were the oxidative stress (elevated mda/decreased sod), inflammation (elevated tnf-α/decreased il-10), and cardiac apoptosis (lower bcl2, higher bax, and lower bcl2/bax ratio). |
2019-12-02 |
2023-08-13 |
rat |
| Clara R L Oudenaarden, Robert A H van de Ven, Patrick W B Derkse. Re-inforcing the cell death army in the fight against breast cancer. Journal of cell science. vol 131. issue 16. 2019-11-25. PMID:30139926. |
in this review, we discuss how a pro-apoptotic subgroup of the bcl2 protein family, known as the bh3-only proteins, controls apoptosis and anoikis during mammary gland homeostasis and to what extent their inhibition confers tumor suppressive functions in metastatic breast cancer. |
2019-11-25 |
2023-08-13 |
Not clear |
| Mahnaz Ramezani, Mahin Ramezani, Ali Darekordi, Gholamhossein Hassanshahi, Mohammad Reza Mirzae. The New Compound of (2R, 4S)-N-(2, 5-difluorophenyl)-4-Hydroxy-1-(2, 2, 2-Trifluoroacetyl) Pyrrolidine-2-Carboxamide to Mediate the Expression of Some Apoptosis Genes by the HepG2 Cell Line Asian Pacific journal of cancer prevention : APJCP. vol 20. issue 5. 2019-11-22. PMID:31127908. |
after 48 hours from theculture, the expressional profiles of apoptosis pathway genes (84 genes) were studied using the pcr array method.results: the findings demonstrated that the expression of some apoptosis-related genes pertaining to tnf, bcl2,iap, and caspase families was regulated by (2r, 4s)-n-(2, 5-difluorophenyl)-4-hydroxy-1-(2, 2, 2-trifluoroacetyl)pyrrolidine-2-carboxamide. |
2019-11-22 |
2023-08-13 |
Not clear |
| Prasath Manogaran, Narasimha Murthy Beeraka, Chih-Yang Huang, Viswanadha Vijaya Padm. Neferine and isoliensinine enhance 'intracellular uptake of cisplatin' and induce 'ROS-mediated apoptosis' in colorectal cancer cells - A comparative study. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 132. 2019-11-22. PMID:31255669. |
combination regimens induced downregulation of bcl2 and upregulation of cytochrome c, caspase 3, 9, parp cleavage indicating apoptosis induction through the intrinsic pathway. |
2019-11-22 |
2023-08-13 |
Not clear |
| Zenghui Li, Ning Li, Xiaomei Sun, Jing Wan. FAM98A promotes cancer progression in endometrial carcinoma. Molecular and cellular biochemistry. vol 459. issue 1-2. 2019-11-21. PMID:31114934. |
in addition, fam98a-knockdown stimulated remarkable cell apoptosis, which might be mediated by down-regulation of bcl2 and up-regulation of bax. |
2019-11-21 |
2023-08-13 |
Not clear |
| Robert W Nickell. WITHDRAWN: Reprint of: Variations in the rheostat model of apoptosis: What studies of retinal ganglion cell death tell us about the functions of the Bcl2 family proteins. Experimental eye research. 2019-11-20. PMID:21819979. |
withdrawn: reprint of: variations in the rheostat model of apoptosis: what studies of retinal ganglion cell death tell us about the functions of the bcl2 family proteins. |
2019-11-20 |
2023-08-12 |
Not clear |
| X L Shu, H Xu, T T Yu, J X Zhong, T Le. Regulation of apoptosis in human gastric cancer cell line SGC-7901 by L-arginine. Panminerva medica. 2019-11-20. PMID:24642529. |
expression and activation of proteins pertinent to apoptosis (bcl2, surviving, p53, and xiap) were studied using pcr, western blot, and activity assays. |
2019-11-20 |
2023-08-12 |
human |
| S Henriques, E Silva, S Cruz, M F Silva, G Ferreira-Dias, L Lopes-da-Costa, L Mateu. Oestrous cycle-dependent expression of Fas and Bcl2 family gene products in normal canine endometrium. Reproduction, fertility, and development. 2019-11-20. PMID:25707315. |
high bcl2 expression in both the follicular and early dioestrous phases stimulate glandular proliferation and prevent apoptosis but, in the non-pregnant uterus, a decrease in bcl2 expression together with an increase in pro-apoptotic proteins induces apoptosis of basal glandular epithelium cells. |
2019-11-20 |
2023-08-13 |
Not clear |
| Dong Li, Cuiping Li, Yanzhi Song, Min Zhou, Xuemei Sun, Xuejun Zhu, Fan Zhang, Chen Zhou, Yahong Huan, Suqin Xia, Xingli Zhuo, Ping Dong, Xuemei Sui, Haiying Liao, Zhong-Fa Yan. Marsdenia tenacssima extract and its functional components inhibits proliferation and induces apoptosis of human Burkitt leukemia/lymphoma cells in vitro and in vivo. Leukemia & lymphoma. vol 57. issue 2. 2019-11-20. PMID:25942381. |
tgta and tgtb significantly increased tumor cell apoptosis on lymphoma bearing mice, primarily through down-regulation of bcl2 and bcl-xl and up-regulation of bid. |
2019-11-20 |
2023-08-13 |
mouse |
| San-Qiang Li, Zhi-Hong Hu, Sha Zhu, Dong-Mei Wang, Hong-Mei Han, Hua-Jie L. The Effect of ADAM8 on the Proliferation and Apoptosis of Hepatocytes and Hepatoma Carcinoma Cells. Journal of biochemical and molecular toxicology. vol 29. issue 9. 2019-11-20. PMID:26293243. |
apoptosis experiment in vitro showed that recombinant adam8 did not induce or inhibit the expression of apoptosis-related factors bcl2, bax, and caspase3 in l02 cells, but significantly induced the expression of bcl2, inhibited the expression of bax and caspase3 in hepg2 cells. |
2019-11-20 |
2023-08-13 |
mouse |
| Zohreh Jahanafrooz, Nasrin Motamed, Behnaz Bakhshande. Effects of miR-21 downregulation and silibinin treatment in breast cancer cell lines. Cytotechnology. vol 69. issue 4. 2019-11-20. PMID:28321778. |
compared to silibinin, mir-21 mimic transfection in combination with silibinin caused a slight modulation in some of the examined silibinin effects including apoptosis, bcl2 mrna and pten mrna and protein levels. |
2019-11-20 |
2023-08-13 |
Not clear |