| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sara Cheleschi, Sara Tenti, Nicola Mondanelli, Claudio Corallo, Marcella Barbarino, Stefano Giannotti, Ines Gallo, Antonio Giordano, Antonella Fioravant. MicroRNA-34a and MicroRNA-181a Mediate Visfatin-Induced Apoptosis and Oxidative Stress via NF-κB Pathway in Human Osteoarthritic Chondrocytes. Cells. vol 8. issue 8. 2020-05-11. PMID:31405216. |
visfatin significantly induced apoptosis and superoxide anion production, increased mir-34a, mir-181a, superoxide dismutase (sod)-2, catalase (cat), nrf2 and decreased bcl2 gene and protein expression in oa chondrocytes. |
2020-05-11 |
2023-08-13 |
human |
| Juan Bautista Menendez-Gonzalez, Milica Vukovic, Ali Abdelfattah, Lubaid Saleh, Alhomidi Almotiri, Leigh-Anne Thomas, Aloña Agirre-Lizaso, Aleksandra Azevedo, Ana Catarina Menezes, Giusy Tornillo, Sarah Edkins, Kay Kong, Peter Giles, Fernando Anjos-Afonso, Alex Tonks, Ashleigh S Boyd, Kamil R Kranc, Neil P Rodrigue. Gata2 as a Crucial Regulator of Stem Cells in Adult Hematopoiesis and Acute Myeloid Leukemia. Stem cell reports. vol 13. issue 2. 2020-04-23. PMID:31378673. |
ablation of gata2 enforces an lsc-specific program of enhanced apoptosis, exemplified by attenuation of anti-apoptotic factor bcl2, and re-instigation of myeloid differentiation--which is characteristically blocked in aml. |
2020-04-23 |
2023-08-13 |
mouse |
| Thu Ha Pham, Lohann Derian, Christine Kervarrec, Pierre-Yves Kernanec, Bernard Jégou, Fatima Smagulova, Aurore Gely-Perno. Perinatal Exposure to Glyphosate and a Glyphosate-Based Herbicide Affect Spermatogenesis in Mice. Toxicological sciences : an official journal of the Society of Toxicology. vol 169. issue 1. 2020-04-20. PMID:30785197. |
moreover, the undifferentiated spermatogonia numbers were decreased by 60% in 5 mg/kg/day glyphosate group, which could be due to the alterations in the expression of genes involved in germ cell differentiation such as sall4 and nano3 and apoptosis as bax and bcl2. |
2020-04-20 |
2023-08-13 |
mouse |
| Zhen Cheng, Weiwei Sun, Xiaohui Ni, Hua Xu, Youhua Wan. GAB2 inhibits chondrocyte apoptosis through PI3K-AKT signaling in osteoarthritis. International journal of clinical and experimental pathology. vol 13. issue 3. 2020-04-11. PMID:32269703. |
moreover, gab2 knockdown inhibited akt phosphorylation, increased bax expression, and decreased bcl2 expression, which indicated that gab2 regulates chondrocyte apoptosis through pi3k-akt signaling. |
2020-04-11 |
2023-08-13 |
Not clear |
| Chao He, Chao Liu, Lei Wang, Yangbai Sun, Yuhang Jiang, Yongqiang Ha. Histone methyltransferase NSD2 regulates apoptosis and chemosensitivity in osteosarcoma. Cell death & disease. vol 10. issue 2. 2020-04-06. PMID:30683853. |
the results of chromatin immunoprecipitation quantitative polymerase chain reaction (chip-qpcr) assays indicated that nsd2 knockdown leads to decreased h3k36me2 modification at bcl2 and sox2 loci, thus inhibiting the transcription of these two genes that are closely correlated with apoptosis, csc properties and chemosensitivity in os cells. |
2020-04-06 |
2023-08-13 |
Not clear |
| Chao He, Chao Liu, Lei Wang, Yangbai Sun, Yuhang Jiang, Yongqiang Ha. Histone methyltransferase NSD2 regulates apoptosis and chemosensitivity in osteosarcoma. Cell death & disease. vol 10. issue 2. 2020-04-06. PMID:30683853. |
nsd2 regulates the expression of the apoptosis regulatory proteins bcl2 and sox2 through the erk and akt pathways. |
2020-04-06 |
2023-08-13 |
Not clear |
| Wenhui Zhou, Huan Fang, Qiuju Wu, Xinye Wang, Rong Liu, Fubin Li, Ji Xiao, Lin Yuan, Zhongmei Zhou, Junying Ma, Lulu Wang, Weiwei Zhao, Hua You, Jianhua Ju, Jing Feng, Ceshi Che. Ilamycin E, a natural product of marine actinomycete, inhibits triple-negative breast cancer partially through ER stress-CHOP-Bcl-2. International journal of biological sciences. vol 15. issue 8. 2020-04-06. PMID:31360114. |
depletion of chop or overexpression of bcl2 significantly rescued ilamycin e-induced apoptosis. |
2020-04-06 |
2023-08-13 |
Not clear |
| S L Xie, M Wang, X H Du, Z W Zhao, G Y L. [miR-455 Inhibits HepG2 Cell Proliferation and Promotes Apoptosis by Targeting RhoC]. Molekuliarnaia biologiia. vol 54. issue 1. 2020-04-06. PMID:32163390. |
as pten is a key tumor suppressor gene in hcc, and bcl-2 and caspase 3 are important indication of apoptosis, expression levels of pten, bcl2 and caspase 3 proteins were determined in cells overexpressing rhoc. |
2020-04-06 |
2023-08-13 |
Not clear |
| S L Xie, M Wang, X H Du, Z W Zhao, G Y L. [miR-455 Inhibits HepG2 Cell Proliferation and Promotes Apoptosis by Targeting RhoC]. Molekuliarnaia biologiia. vol 54. issue 1. 2020-04-06. PMID:32163390. |
in addition, we show that rhoc could activate the hcc cells proliferation ability and inhibit apoptosis rate (p < 0.01), and decrease expression of pten and caspase 3 (p < 0.01), while upregulating levels of bcl2. |
2020-04-06 |
2023-08-13 |
Not clear |
| Bruce Weder, Céline Mamie, Gerhard Rogler, Stephen Clarke, Bradford McRae, Pedro A Ruiz, Martin Hausman. BCL2 Regulates Differentiation of Intestinal Fibroblasts. Inflammatory bowel diseases. vol 24. issue 9. 2020-03-30. PMID:29796658. |
activation of fibroblasts is linked to the b-cell lymphoma 2 (bcl2) family, which is involved in the induction of apoptosis. |
2020-03-30 |
2023-08-13 |
Not clear |
| Didar Yanardag Acik, Mehmet Bankir, Filiz Alkan Baylan, Bilal Aygu. Can ELABELA be a novel target in the treatment of chronic lymphocytic leukaemia? BMC cancer. vol 19. issue 1. 2020-03-30. PMID:31718601. |
it has been shown that bcl2, bcl-xl and mcl-1 protein levels are high in chronic lymphocytic leukemia cells, and resultantly, apoptosis does not occur chronic lymphocytic leukemia cells. |
2020-03-30 |
2023-08-13 |
human |
| Ket Hing Chong, Sandhya Samarasinghe, Don Kulasiri, Jie Zhen. Mathematical modelling of core regulatory mechanism in p53 protein that activates apoptotic switch. Journal of theoretical biology. vol 462. 2020-03-23. PMID:30439375. |
building on previous models (chong et al., 2015; zhang et al., 2009a), we developed a mathematical model that incorporated the molecular interactions in the core regulation of p53 and the apoptosis initiation module involving puma, bcl2 and bax. |
2020-03-23 |
2023-08-13 |
Not clear |
| Ket Hing Chong, Sandhya Samarasinghe, Don Kulasiri, Jie Zhen. Mathematical modelling of core regulatory mechanism in p53 protein that activates apoptotic switch. Journal of theoretical biology. vol 462. 2020-03-23. PMID:30439375. |
our simulation results are qualitatively consistent with the experimental findings of all-or-none activation of apoptosis and predicted overexpression of bcl2 as a factor in causing malfunction of the apoptotic switch. |
2020-03-23 |
2023-08-13 |
Not clear |
| P Cao, Y Feng, M Deng, J Li, H Cai, Q Meng, W Fang, Y Li, J Ke, X Lon. MiR-15b is a key regulator of proliferation and apoptosis of chondrocytes from patients with condylar hyperplasia by targeting IGF1, IGF1R and BCL2. Osteoarthritis and cartilage. vol 27. issue 2. 2020-03-23. PMID:30521861. |
mir-15b is a key regulator of proliferation and apoptosis of chondrocytes from patients with condylar hyperplasia by targeting igf1, igf1r and bcl2. |
2020-03-23 |
2023-08-13 |
Not clear |
| Chidimma Agatha Akpa, Karsten Kleo, Dido Lenze, Elisabeth Oker, Lora Dimitrova, Michael Humme. DZNep-mediated apoptosis in B-cell lymphoma is independent of the lymphoma type, EZH2 mutation status and MYC, BCL2 or BCL6 translocations. PloS one. vol 14. issue 8. 2020-03-23. PMID:31419226. |
dznep-mediated apoptosis in b-cell lymphoma is independent of the lymphoma type, ezh2 mutation status and myc, bcl2 or bcl6 translocations. |
2020-03-23 |
2023-08-13 |
Not clear |
| Chidimma Agatha Akpa, Karsten Kleo, Dido Lenze, Elisabeth Oker, Lora Dimitrova, Michael Humme. DZNep-mediated apoptosis in B-cell lymphoma is independent of the lymphoma type, EZH2 mutation status and MYC, BCL2 or BCL6 translocations. PloS one. vol 14. issue 8. 2020-03-23. PMID:31419226. |
we aimed to address the impact of the lymphoma type, ezh2 mutation status, as well as myc, bcl2 and bcl6 translocations on the sensitivity of the lymphoma cell lines to dznep-mediated apoptosis. |
2020-03-23 |
2023-08-13 |
Not clear |
| Chidimma Agatha Akpa, Karsten Kleo, Dido Lenze, Elisabeth Oker, Lora Dimitrova, Michael Humme. DZNep-mediated apoptosis in B-cell lymphoma is independent of the lymphoma type, EZH2 mutation status and MYC, BCL2 or BCL6 translocations. PloS one. vol 14. issue 8. 2020-03-23. PMID:31419226. |
we show that dznep inhibits proliferation and induces apoptosis of these cell lines independent of the type of lymphoma, the ezh2 mutation status and the myc, bcl2 and bcl6 rearrangement status. |
2020-03-23 |
2023-08-13 |
Not clear |
| Chidimma Agatha Akpa, Karsten Kleo, Dido Lenze, Elisabeth Oker, Lora Dimitrova, Michael Humme. DZNep-mediated apoptosis in B-cell lymphoma is independent of the lymphoma type, EZH2 mutation status and MYC, BCL2 or BCL6 translocations. PloS one. vol 14. issue 8. 2020-03-23. PMID:31419226. |
although ezh2, myc, bcl2 and bcl6 are important prognostic biomarkers for lymphomas, our study shows that they poorly influence the sensitivity of lymphoma cell lines to dznep-mediated apoptosis. |
2020-03-23 |
2023-08-13 |
Not clear |
| Jun Lu, Nina Zhou, Ping Yang, Lanqiuzi Deng, Ganzhe Li. MicroRNA-27a-3p Downregulation Inhibits Inflammatory Response and Hippocampal Neuronal Cell Apoptosis by Upregulating Mitogen-Activated Protein Kinase 4 (MAP2K4) Expression in Epilepsy: In Vivo and In Vitro Studies. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2020-03-23. PMID:31710596. |
mir-27a-3p inhibitor also inhibited apoptosis of hippocampal neurons in epileptic rats, promoted bcl2 expression, and decreased bax and caspase3 expression. |
2020-03-23 |
2023-08-13 |
rat |
| Xiao-Mian Lin, Song Li, Chao Zhou, Rong-Zhen Li, Heng Wang, Wu Luo, Yi-Shan Huang, Lian-Kuai Chen, Jia-Long Cai, Tian-Xiang Wang, Qi-Hao Zhang, Hong Cao, Xiao-Ping W. Cisplatin induces chemoresistance through the PTGS2-mediated anti-apoptosis in gastric cancer. The international journal of biochemistry & cell biology. vol 116. 2020-03-20. PMID:31518663. |
in addition, ptgs2 mediated cisplatin-induced bcl2 expression and subsequent resistance to apoptosis via pge2/ep4/mapks (erk1/2, p38) axis. |
2020-03-20 |
2023-08-13 |
human |