| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jan Dusek, Josef Skoda, Ondrej Holas, Alzbeta Horvatova, Tomas Smutny, Lenka Linhartova, Petra Hirsova, Otto Kucera, Stanislav Micuda, Albert Braeuning, Petr Pave. Stilbene compound trans-3,4,5,4´-tetramethoxystilbene, a potential anticancer drug, regulates constitutive androstane receptor (Car) target genes, but does not possess proliferative activity in mouse liver. Toxicology letters. vol 313. 2019-07-29. PMID:31170421. |
tms did not change or down-regulate genes involved in liver proliferation or apoptosis such as mki67, foxm1, myc, mcl1, pcna, bcl2, or mdm2, which were up-regulated by another car ligand tcpobop. |
2019-07-29 |
2023-08-13 |
mouse |
| Sofía Jerez, Héctor Araya, Daniel Hevia, Carlos E Irarrázaval, Roman Thaler, Andre J van Wijnen, Mario Galind. Extracellular vesicles from osteosarcoma cell lines contain miRNAs associated with cell adhesion and apoptosis. Gene. vol 710. 2019-07-22. PMID:31176732. |
gene ontology analysis of predicted targets reveals that mirnas present in evs may regulate the metastatic potential of osteosarcoma cell lines by potentially inhibiting a network of genes (e.g., mapk1, nras, frs2, prcke, bcl2 and qki) involved in apoptosis and/or cell adhesion. |
2019-07-22 |
2023-08-13 |
human |
| Feifei Liu, Xueyin Zu, Xiaomeng Xie, Kangdong Liu, Hanyong Chen, Ting Wang, Fangfang Liu, Ann M Bode, Yan Zheng, Zigang Dong, Dong Joon Ki. Ethyl gallate as a novel ERK1/2 inhibitor suppresses patient-derived esophageal tumor growth. Molecular carcinogenesis. vol 58. issue 4. 2019-07-05. PMID:30499613. |
the compound also stimulated cellular apoptosis through the activation of caspases 3 and 7 and inhibition of bcl2 expression. |
2019-07-05 |
2023-08-13 |
mouse |
| S Q Feng, X Y Zhang, H T Fan, Q J Sun, M Zhan. Up-regulation of LncRNA MEG3 inhibits cell migration and invasion and enhances cisplatin chemosensitivity in bladder cancer cells. Neoplasma. vol 65. issue 6. 2019-07-01. PMID:29940769. |
ddp treatment significantly induced cell apoptosis, down-regulated bcl2 expression, and up-regulated cleaved-caspase-3 and bax expression in bc cells with meg3 over-expression. |
2019-07-01 |
2023-08-13 |
Not clear |
| L N Huiting, Y Samaha, G L Zhang, J E Roderick, B Li, N M Anderson, Y W Wang, L Wang, Fjf Laroche, J W Choi, C T Liu, M A Kelliher, H Fen. UFD1 contributes to MYC-mediated leukemia aggressiveness through suppression of the proapoptotic unfolded protein response. Leukemia. vol 32. issue 11. 2019-06-13. PMID:29743725. |
indeed, chop inactivation or bcl2 overexpression is sufficient to rescue tumor cell apoptosis induced by ufd1 knockdown. |
2019-06-13 |
2023-08-13 |
human |
| Hong Ri Jin, Charles H Du, Chong-Zhi Wang, Chun-Su Yuan, Wei D. Ginseng metabolite protopanaxadiol interferes with lipid metabolism and induces endoplasmic reticulum stress and p53 activation to promote cancer cell death. Phytotherapy research : PTR. vol 33. issue 3. 2019-06-11. PMID:30537241. |
on the other hand, ppd also induced prosurvival mechanisms including autophagy and expression of bcl2 family apoptosis regulator mcl-1. |
2019-06-11 |
2023-08-13 |
Not clear |
| Federico Lucantoni, Andreas U Lindner, Norma O'Donovan, Heiko Düssmann, Jochen H M Preh. Systems modeling accurately predicts responses to genotoxic agents and their synergism with BCL-2 inhibitors in triple negative breast cancer cells. Cell death & disease. vol 9. issue 2. 2019-06-10. PMID:29352235. |
the bcl2 (b-cell lymphoma 2) family of proteins controls the process of mitochondrial outer membrane permeabilization (momp), which is required for the activation of the mitochondrial apoptosis pathway in response to genotoxic agents. |
2019-06-10 |
2023-08-13 |
Not clear |
| Federico Lucantoni, Andreas U Lindner, Norma O'Donovan, Heiko Düssmann, Jochen H M Preh. Systems modeling accurately predicts responses to genotoxic agents and their synergism with BCL-2 inhibitors in triple negative breast cancer cells. Cell death & disease. vol 9. issue 2. 2019-06-10. PMID:29352235. |
we previously developed a deterministic systems model of bcl2 protein interactions, dr_momp that calculates the sensitivity of cells to undergo mitochondrial apoptosis. |
2019-06-10 |
2023-08-13 |
Not clear |
| Francesca Rossi, Chiara Tortora, Giuseppe Palumbo, Francesca Punzo, Maura Argenziano, Maddalena Casale, Alessandra Di Paola, Franco Locatelli, Silverio Perrott. CB2 Receptor Stimulation and Dexamethasone Restore the Anti-Inflammatory and Immune-Regulatory Properties of Mesenchymal Stromal Cells of Children with Immune Thrombocytopenia. International journal of molecular sciences. vol 20. issue 5. 2019-06-05. PMID:30823385. |
moreover, we demonstrated that cb₂ stimulation and dexa attenuate apoptosis, via bcl2 signaling, and restore the immune-modulatory properties of mscs derived from itp patients. |
2019-06-05 |
2023-08-13 |
human |
| James B Studd, Minjun Yang, Zhenhua Li, Jayaram Vijayakrishnan, Yi Lu, Allen Eng-Juh Yeoh, Kajsa Paulsson, Richard S Houlsto. Genetic predisposition to B-cell acute lymphoblastic leukemia at 14q11.2 is mediated by a CEBPE promoter polymorphism. Leukemia. vol 33. issue 1. 2019-05-30. PMID:29977016. |
rna-seq in cebpe depleted cells demonstrates cebpe regulates the expression of genes involved in b-cell development (il7r), apoptosis (bcl2), and methotrexate resistance (rass4l). |
2019-05-30 |
2023-08-13 |
Not clear |
| Chuiming Jia, Dejuan Kong, Yiwei Guo, Lianqiao Li, Lina Qua. Enhanced antitumor effect of combination of annexin A1 knockdown and bortezomib treatment in multiple myeloma in vitro and in vivo. Biochemical and biophysical research communications. vol 505. issue 3. 2019-05-28. PMID:30292410. |
cell apoptosis was dramatically promoted in mm cells following silencing of anxa1 and btz administration versus that in anxa1-silenced alone or btz-treated alone cells, as evidenced by decreased expression of phosphorylated signal transducers and activators of transcription 3 and bcl2, and increased expression of bax. |
2019-05-28 |
2023-08-13 |
Not clear |
| Xia Wang, Xu Liu, Yuan Ren, Ying Liu, Shuangyu Han, Jingkang Zhao, Xingchun Gou, Yuan H. PEDF protects human retinal pigment epithelial cells against oxidative stress via upregulation of UCP2 expression. Molecular medicine reports. vol 19. issue 1. 2019-05-28. PMID:30431098. |
the expression levels of caspase 3 and b cell lymphoma (bcl2) associated x genes associated with apoptosis were inhibited, whereas levels of the anti‑apoptotic gene bcl2 were enhanced following treatment with pedf in different passages of arpe‑19 cells. |
2019-05-28 |
2023-08-13 |
mouse |
| Shu-Jun Liu, Wen-Ting Wang, Feng-Lan Zhang, Yong-Hong Yu, Hua-Jun Yu, Yan Liang, Ning Li, Yuan-Bin L. miR‑15a‑3p affects the proliferation, migration and apoptosis of lens epithelial cells. Molecular medicine reports. vol 19. issue 2. 2019-05-24. PMID:30569090. |
in conclusion, mir‑15a‑3p may suppress cell proliferation and migration, and induce cell apoptosis in lens epithelial cells through inhibiting the expression of bcl2 and mcl1, which contributes to the onset of arcs. |
2019-05-24 |
2023-08-13 |
human |
| Hasan Riaz, Muhammad Rizwan Yousuf, Aixin Liang, Guo Hua Hua, Liguo Yan. Effect of melatonin on regulation of apoptosis and steroidogenesis in cultured buffalo granulosa cells. Animal science journal = Nihon chikusan Gakkaiho. vol 90. issue 4. 2019-05-17. PMID:30793438. |
melatonin supplementation suppressed apoptosis (100 nm, p < 0.05) and enhanced g2/m phase (1 nm, 100 nm, p < 0.05) of cell cycle progression which was further corroborated by decrease in protein expression of caspase-3, p21, and p27 and increase in bcl2. |
2019-05-17 |
2023-08-13 |
Not clear |
| Anita Skakic, Marina Andjelkovic, Natasa Tosic, Kristel Klaassen, Maja Djordjevic, Sonja Pavlovic, Maja Stojiljkovi. CRISPR/Cas9 genome editing of SLC37A4 gene elucidates the role of molecular markers of endoplasmic reticulum stress and apoptosis in renal involvement in glycogen storage disease type Ib. Gene. vol 703. 2019-05-17. PMID:30951856. |
in this model system we used rt-qpcr analysis to investigate the expression of molecular markers of the upr response (atf4, ddit3, hspa5, and xbp1s) and apoptosis (bcl2, bax). |
2019-05-17 |
2023-08-13 |
human |
| Ahmad Khosravi, Iraj Sharifi, Hadi Tavakkoli, Ali Reza Keyhani, Ali Afgar, Zohreh Salari, Seyedeh Saedeh Mosallanejad, Mehdi Bamorovat, Fatemeh Sharifi, Saeid Hassanzadeh, Balal Sadeghi, Shahriar Dabiri, Abbas Mortazaeizdeh, Zahra Sheikhshoaie, Ehsan Salarki. Vascular apoptosis associated with meglumine antimoniate: In vivo investigation of a chick embryo model. Biochemical and biophysical research communications. vol 505. issue 3. 2019-05-13. PMID:30297110. |
in addition, ihc assay confirmed the low expression bcl2 and increased expression of bax, which are associated with a high rate of apoptosis. |
2019-05-13 |
2023-08-13 |
chicken |
| Shuang Wang, Jingyi Chen, Wenqian Yu, Fan Den. Circular RNA DLGAP4 ameliorates cardiomyocyte apoptosis through regulating BCL2 via targeting miR-143 in myocardial ischemia-reperfusion injury. International journal of cardiology. vol 279. 2019-05-08. PMID:30213603. |
circular rna dlgap4 ameliorates cardiomyocyte apoptosis through regulating bcl2 via targeting mir-143 in myocardial ischemia-reperfusion injury. |
2019-05-08 |
2023-08-13 |
Not clear |
| María Itatí Albamonte, Mirta Susana Albamonte, Ricardo M Bou-Khair, Luis Zuccardi, Alfredo Daniel Vitull. The ovarian germinal reserve and apoptosis-related proteins in the infant and adolescent human ovary. Journal of ovarian research. vol 12. issue 1. 2019-05-01. PMID:30857552. |
we evaluated the expression of pro- and anti-apoptotic members of the bcl2 gene family, the fas/fas-l proteins from the extrinsic apoptosis pathway, the germ-cell-specific marker vasa, the pluripotency marker oct3/4, and markers of early and late apoptosis in the ovary of pubertal patients with malignant extra-gonadal disease, which received or not pre-surgery chemotherapy, entering a cryopreservation program. |
2019-05-01 |
2023-08-13 |
human |
| Xiaolu Zhang, Jing Liu, Yufeng Gu, Chengming Sun, Fuzheng Q. Down-regulation of lncRNA OGFRP1 induces autophagy and growth inhibition by AKT/mTOR signaling pathway in HCAECs. Cell biology international. vol 43. issue 2. 2019-04-30. PMID:30536541. |
the intrinsic apoptosis pathway was activated in lncrna ogfrp1 silenced cells, including increased bax and active-caspase 3 and decreased bcl2. |
2019-04-30 |
2023-08-13 |
human |
| Xi Zhang, Yuliang Pan, Huiqun Fu, Juan Zhan. microRNA-205 and microRNA-338-3p Reduces Cell Apoptosis in Prostate Carcinoma Tissue and LNCaP Prostate Carcinoma Cells by Directly Targeting the B-Cell Lymphoma 2 (Bcl-2) Gene. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2019-04-29. PMID:30741252. |
background the inhibitor of apoptosis, b-cell lymphoma 2 (bcl-2), is encoded by the bcl2 gene. |
2019-04-29 |
2023-08-13 |
human |