| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S M Zaki, Wa Abd Algaleel, R A Imam, M M Abdelmoat. Mesenchymal stem cells pretreated with platelet-rich plasma modulate doxorubicin-induced cardiotoxicity. Human & experimental toxicology. vol 38. issue 7. 2019-12-02. PMID:30991846. |
the major factors in the dox-induced cardiotoxicity were the oxidative stress (elevated mda/decreased sod), inflammation (elevated tnf-α/decreased il-10), and cardiac apoptosis (lower bcl2, higher bax, and lower bcl2/bax ratio). |
2019-12-02 |
2023-08-13 |
rat |
| Clara R L Oudenaarden, Robert A H van de Ven, Patrick W B Derkse. Re-inforcing the cell death army in the fight against breast cancer. Journal of cell science. vol 131. issue 16. 2019-11-25. PMID:30139926. |
in this review, we discuss how a pro-apoptotic subgroup of the bcl2 protein family, known as the bh3-only proteins, controls apoptosis and anoikis during mammary gland homeostasis and to what extent their inhibition confers tumor suppressive functions in metastatic breast cancer. |
2019-11-25 |
2023-08-13 |
Not clear |
| Mahnaz Ramezani, Mahin Ramezani, Ali Darekordi, Gholamhossein Hassanshahi, Mohammad Reza Mirzae. The New Compound of (2R, 4S)-N-(2, 5-difluorophenyl)-4-Hydroxy-1-(2, 2, 2-Trifluoroacetyl) Pyrrolidine-2-Carboxamide to Mediate the Expression of Some Apoptosis Genes by the HepG2 Cell Line Asian Pacific journal of cancer prevention : APJCP. vol 20. issue 5. 2019-11-22. PMID:31127908. |
after 48 hours from theculture, the expressional profiles of apoptosis pathway genes (84 genes) were studied using the pcr array method.results: the findings demonstrated that the expression of some apoptosis-related genes pertaining to tnf, bcl2,iap, and caspase families was regulated by (2r, 4s)-n-(2, 5-difluorophenyl)-4-hydroxy-1-(2, 2, 2-trifluoroacetyl)pyrrolidine-2-carboxamide. |
2019-11-22 |
2023-08-13 |
Not clear |
| Prasath Manogaran, Narasimha Murthy Beeraka, Chih-Yang Huang, Viswanadha Vijaya Padm. Neferine and isoliensinine enhance 'intracellular uptake of cisplatin' and induce 'ROS-mediated apoptosis' in colorectal cancer cells - A comparative study. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 132. 2019-11-22. PMID:31255669. |
combination regimens induced downregulation of bcl2 and upregulation of cytochrome c, caspase 3, 9, parp cleavage indicating apoptosis induction through the intrinsic pathway. |
2019-11-22 |
2023-08-13 |
Not clear |
| Zenghui Li, Ning Li, Xiaomei Sun, Jing Wan. FAM98A promotes cancer progression in endometrial carcinoma. Molecular and cellular biochemistry. vol 459. issue 1-2. 2019-11-21. PMID:31114934. |
in addition, fam98a-knockdown stimulated remarkable cell apoptosis, which might be mediated by down-regulation of bcl2 and up-regulation of bax. |
2019-11-21 |
2023-08-13 |
Not clear |
| Robert W Nickell. WITHDRAWN: Reprint of: Variations in the rheostat model of apoptosis: What studies of retinal ganglion cell death tell us about the functions of the Bcl2 family proteins. Experimental eye research. 2019-11-20. PMID:21819979. |
withdrawn: reprint of: variations in the rheostat model of apoptosis: what studies of retinal ganglion cell death tell us about the functions of the bcl2 family proteins. |
2019-11-20 |
2023-08-12 |
Not clear |
| X L Shu, H Xu, T T Yu, J X Zhong, T Le. Regulation of apoptosis in human gastric cancer cell line SGC-7901 by L-arginine. Panminerva medica. 2019-11-20. PMID:24642529. |
expression and activation of proteins pertinent to apoptosis (bcl2, surviving, p53, and xiap) were studied using pcr, western blot, and activity assays. |
2019-11-20 |
2023-08-12 |
human |
| S Henriques, E Silva, S Cruz, M F Silva, G Ferreira-Dias, L Lopes-da-Costa, L Mateu. Oestrous cycle-dependent expression of Fas and Bcl2 family gene products in normal canine endometrium. Reproduction, fertility, and development. 2019-11-20. PMID:25707315. |
high bcl2 expression in both the follicular and early dioestrous phases stimulate glandular proliferation and prevent apoptosis but, in the non-pregnant uterus, a decrease in bcl2 expression together with an increase in pro-apoptotic proteins induces apoptosis of basal glandular epithelium cells. |
2019-11-20 |
2023-08-13 |
Not clear |
| Dong Li, Cuiping Li, Yanzhi Song, Min Zhou, Xuemei Sun, Xuejun Zhu, Fan Zhang, Chen Zhou, Yahong Huan, Suqin Xia, Xingli Zhuo, Ping Dong, Xuemei Sui, Haiying Liao, Zhong-Fa Yan. Marsdenia tenacssima extract and its functional components inhibits proliferation and induces apoptosis of human Burkitt leukemia/lymphoma cells in vitro and in vivo. Leukemia & lymphoma. vol 57. issue 2. 2019-11-20. PMID:25942381. |
tgta and tgtb significantly increased tumor cell apoptosis on lymphoma bearing mice, primarily through down-regulation of bcl2 and bcl-xl and up-regulation of bid. |
2019-11-20 |
2023-08-13 |
mouse |
| San-Qiang Li, Zhi-Hong Hu, Sha Zhu, Dong-Mei Wang, Hong-Mei Han, Hua-Jie L. The Effect of ADAM8 on the Proliferation and Apoptosis of Hepatocytes and Hepatoma Carcinoma Cells. Journal of biochemical and molecular toxicology. vol 29. issue 9. 2019-11-20. PMID:26293243. |
apoptosis experiment in vitro showed that recombinant adam8 did not induce or inhibit the expression of apoptosis-related factors bcl2, bax, and caspase3 in l02 cells, but significantly induced the expression of bcl2, inhibited the expression of bax and caspase3 in hepg2 cells. |
2019-11-20 |
2023-08-13 |
mouse |
| Zohreh Jahanafrooz, Nasrin Motamed, Behnaz Bakhshande. Effects of miR-21 downregulation and silibinin treatment in breast cancer cell lines. Cytotechnology. vol 69. issue 4. 2019-11-20. PMID:28321778. |
compared to silibinin, mir-21 mimic transfection in combination with silibinin caused a slight modulation in some of the examined silibinin effects including apoptosis, bcl2 mrna and pten mrna and protein levels. |
2019-11-20 |
2023-08-13 |
Not clear |
| Nadir Kocak, Filiz Ozen, Ibrahim Halil Yildirim, Yagmur Dura. Fentanyl Inhibits Tumorigenesis from Human Breast Stem Cells by Inducing Apoptosis Asian Pacific journal of cancer prevention : APJCP. vol 18. issue 3. 2019-11-20. PMID:28441707. |
gene expression analysis was performed by quantitative real-time pcr assay for the oct4,sox2 and nanog genes as stem cell markers and bax, bcl2, and p53 genes as apoptosis markers. |
2019-11-20 |
2023-08-13 |
human |
| Xin Jiang, Yaqiong Hong, Di Zhao, Xinxin Meng, Lijing Zhao, Yanwei Du, Zan Wang, Yan Zheng, Lu Cai, Hongyu Jian. Low dose radiation prevents doxorubicin-induced cardiotoxicity. Oncotarget. vol 9. issue 1. 2019-11-20. PMID:29416617. |
pretreatment of dox-treated mice with ldr also decreased dox-induced cardiac cell apoptosis (tunel staining and cleaved caspase-3) and mitochondrial apoptotic pathway (increased p53, bax, and caspase-9 expression and decreased bcl2 expression and ΔΨm dissipation). |
2019-11-20 |
2023-08-13 |
mouse |
| Anna Kovalchuk, Yaroslav Ilnytskyy, Rafal Woycicki, Rocio Rodriguez-Juarez, Gerlinde A S Metz, Olga Kovalchu. Adverse effects of paternal chemotherapy exposure on the progeny brain: intergenerational chemobrain. Oncotarget. vol 9. issue 11. 2019-11-20. PMID:29515791. |
furthermore, there were changes in proliferation and apoptosis proteins bcl2 and akt1, the proteins associated with dna methylation, dnmt1 and mecp2. |
2019-11-20 |
2023-08-13 |
Not clear |
| Federico Lucantoni, Heiko Düssmann, Irene Llorente-Folch, Jochen H M Preh. BCL2 and BCL(X)L selective inhibitors decrease mitochondrial ATP production in breast cancer cells and are synthetically lethal when combined with 2-deoxy-D-glucose. Oncotarget. vol 9. issue 40. 2019-11-20. PMID:29899841. |
bcl2 proteins control the process of mitochondrial outer membrane permeabilization during apoptosis, but also regulate cellular bioenergetics. |
2019-11-20 |
2023-08-13 |
Not clear |
| Seungjin Choi, Kijun Lee, Hyerin Jung, Narae Park, Jaewoo Kang, Ki-Hoan Nam, Eun-Kyeong Kim, Ji Hyeon Ju, Kwi Young Kan. Kruppel-Like Factor 4 Positively Regulates Autoimmune Arthritis in Mouse Models and Rheumatoid Arthritis in Patients Frontiers in immunology. vol 9. 2019-11-20. PMID:29997611. |
we found that blockade of klf4 in fls increased apoptosis and suppressed proliferation followed by downregulation of antiapoptotic factor bcl2. |
2019-11-20 |
2023-08-13 |
mouse |
| Ya-Jen Chiu, Chi-Mei Lee, Te-Hsien Lin, Hsuan-Yuan Lin, Shin-Ying Lee, Mina Mesri, Kuo-Hsuan Chang, Jung-Yaw Lin, Guey-Jen Lee-Chen, Chiung-Mei Che. Chinese Herbal Medicine Glycyrrhiza inflataReduces Aβ Aggregation and Exerts Neuroprotection through Anti-Oxidation and Anti-Inflammation. The American journal of Chinese medicine. 2019-11-20. PMID:30284464. |
g. inflata extract and its constituents further protected a[formula: see text]-gfp sh-sy5y cells from bv-2 cm-induced cell death by ameliorating reduced bcl2 and attenuating increased igfbp2, cleaved casp3, bad and bax. collectively, g. inflata extract, licochalcone a and liquiritigenin display neuroprotection through exerting anti-oxidative and anti-inflammatory activities to suppress neuronal apoptosis. |
2019-11-20 |
2023-08-13 |
Not clear |
| Qi Liu, Jie Yang, Yafan Gong, Jingzeng Cai, Ziwei Zhan. Role of miR-731 and miR-2188-3p in mediating chlorpyrifos induced head kidney injury in common carp via targeting TLR and apoptosis pathways. Aquatic toxicology (Amsterdam, Netherlands). vol 215. 2019-11-14. PMID:31479757. |
during cpf exposure, mrna expression of tlr pathway genes and its downstream genes involved in autophagy and apoptosis pathway including tlr1, tlr2, tlr7, tlr9, myd88, irak1, irak4, irf7, pi3k, akt, mtor, caspase3, caspase8 and bax were differentially increased under cpf exposure, along with atg13 and bcl2 decreased at the same time. |
2019-11-14 |
2023-08-13 |
Not clear |
| Weiwei Chen, Hongjing Zhang, Yue Li. Anti-Inflammatory and Apoptotic Signaling Effect of Fucoxanthin on Benzo(A)Pyrene-Induced Lung Cancer in Mice. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. vol 38. issue 3. 2019-11-07. PMID:31679311. |
with respect to apoptosis, fucoxanthin treated animals shows increased apoptosis compared to tumor induced mice by increased expression of caspase 9 and 3 and decreased expression of anti-apoptotic bcl2 protein. |
2019-11-07 |
2023-08-13 |
mouse |
| Andreas U Lindner, Federico Lucantoni, Damir Varešlija, Alexa Resler, Brona M Murphy, William M Gallagher, Arnold D K Hill, Leonie S Young, Jochen H M Preh. Low cleaved caspase-7 levels indicate unfavourable outcome across all breast cancers. Journal of molecular medicine (Berlin, Germany). vol 96. issue 10. 2019-11-05. PMID:30069746. |
we investigated whether executioner caspase activation downstream of mitochondrial apoptosis was associated with, or independent, of bcl2's prognostic signature in breast cancer. |
2019-11-05 |
2023-08-13 |
Not clear |