| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| James B Studd, Minjun Yang, Zhenhua Li, Jayaram Vijayakrishnan, Yi Lu, Allen Eng-Juh Yeoh, Kajsa Paulsson, Richard S Houlsto. Genetic predisposition to B-cell acute lymphoblastic leukemia at 14q11.2 is mediated by a CEBPE promoter polymorphism. Leukemia. vol 33. issue 1. 2019-05-30. PMID:29977016. |
rna-seq in cebpe depleted cells demonstrates cebpe regulates the expression of genes involved in b-cell development (il7r), apoptosis (bcl2), and methotrexate resistance (rass4l). |
2019-05-30 |
2023-08-13 |
Not clear |
| Chuiming Jia, Dejuan Kong, Yiwei Guo, Lianqiao Li, Lina Qua. Enhanced antitumor effect of combination of annexin A1 knockdown and bortezomib treatment in multiple myeloma in vitro and in vivo. Biochemical and biophysical research communications. vol 505. issue 3. 2019-05-28. PMID:30292410. |
cell apoptosis was dramatically promoted in mm cells following silencing of anxa1 and btz administration versus that in anxa1-silenced alone or btz-treated alone cells, as evidenced by decreased expression of phosphorylated signal transducers and activators of transcription 3 and bcl2, and increased expression of bax. |
2019-05-28 |
2023-08-13 |
Not clear |
| Xia Wang, Xu Liu, Yuan Ren, Ying Liu, Shuangyu Han, Jingkang Zhao, Xingchun Gou, Yuan H. PEDF protects human retinal pigment epithelial cells against oxidative stress via upregulation of UCP2 expression. Molecular medicine reports. vol 19. issue 1. 2019-05-28. PMID:30431098. |
the expression levels of caspase 3 and b cell lymphoma (bcl2) associated x genes associated with apoptosis were inhibited, whereas levels of the anti‑apoptotic gene bcl2 were enhanced following treatment with pedf in different passages of arpe‑19 cells. |
2019-05-28 |
2023-08-13 |
mouse |
| Shu-Jun Liu, Wen-Ting Wang, Feng-Lan Zhang, Yong-Hong Yu, Hua-Jun Yu, Yan Liang, Ning Li, Yuan-Bin L. miR‑15a‑3p affects the proliferation, migration and apoptosis of lens epithelial cells. Molecular medicine reports. vol 19. issue 2. 2019-05-24. PMID:30569090. |
in conclusion, mir‑15a‑3p may suppress cell proliferation and migration, and induce cell apoptosis in lens epithelial cells through inhibiting the expression of bcl2 and mcl1, which contributes to the onset of arcs. |
2019-05-24 |
2023-08-13 |
human |
| Hasan Riaz, Muhammad Rizwan Yousuf, Aixin Liang, Guo Hua Hua, Liguo Yan. Effect of melatonin on regulation of apoptosis and steroidogenesis in cultured buffalo granulosa cells. Animal science journal = Nihon chikusan Gakkaiho. vol 90. issue 4. 2019-05-17. PMID:30793438. |
melatonin supplementation suppressed apoptosis (100 nm, p < 0.05) and enhanced g2/m phase (1 nm, 100 nm, p < 0.05) of cell cycle progression which was further corroborated by decrease in protein expression of caspase-3, p21, and p27 and increase in bcl2. |
2019-05-17 |
2023-08-13 |
Not clear |
| Anita Skakic, Marina Andjelkovic, Natasa Tosic, Kristel Klaassen, Maja Djordjevic, Sonja Pavlovic, Maja Stojiljkovi. CRISPR/Cas9 genome editing of SLC37A4 gene elucidates the role of molecular markers of endoplasmic reticulum stress and apoptosis in renal involvement in glycogen storage disease type Ib. Gene. vol 703. 2019-05-17. PMID:30951856. |
in this model system we used rt-qpcr analysis to investigate the expression of molecular markers of the upr response (atf4, ddit3, hspa5, and xbp1s) and apoptosis (bcl2, bax). |
2019-05-17 |
2023-08-13 |
human |
| Ahmad Khosravi, Iraj Sharifi, Hadi Tavakkoli, Ali Reza Keyhani, Ali Afgar, Zohreh Salari, Seyedeh Saedeh Mosallanejad, Mehdi Bamorovat, Fatemeh Sharifi, Saeid Hassanzadeh, Balal Sadeghi, Shahriar Dabiri, Abbas Mortazaeizdeh, Zahra Sheikhshoaie, Ehsan Salarki. Vascular apoptosis associated with meglumine antimoniate: In vivo investigation of a chick embryo model. Biochemical and biophysical research communications. vol 505. issue 3. 2019-05-13. PMID:30297110. |
in addition, ihc assay confirmed the low expression bcl2 and increased expression of bax, which are associated with a high rate of apoptosis. |
2019-05-13 |
2023-08-13 |
chicken |
| Shuang Wang, Jingyi Chen, Wenqian Yu, Fan Den. Circular RNA DLGAP4 ameliorates cardiomyocyte apoptosis through regulating BCL2 via targeting miR-143 in myocardial ischemia-reperfusion injury. International journal of cardiology. vol 279. 2019-05-08. PMID:30213603. |
circular rna dlgap4 ameliorates cardiomyocyte apoptosis through regulating bcl2 via targeting mir-143 in myocardial ischemia-reperfusion injury. |
2019-05-08 |
2023-08-13 |
Not clear |
| María Itatí Albamonte, Mirta Susana Albamonte, Ricardo M Bou-Khair, Luis Zuccardi, Alfredo Daniel Vitull. The ovarian germinal reserve and apoptosis-related proteins in the infant and adolescent human ovary. Journal of ovarian research. vol 12. issue 1. 2019-05-01. PMID:30857552. |
we evaluated the expression of pro- and anti-apoptotic members of the bcl2 gene family, the fas/fas-l proteins from the extrinsic apoptosis pathway, the germ-cell-specific marker vasa, the pluripotency marker oct3/4, and markers of early and late apoptosis in the ovary of pubertal patients with malignant extra-gonadal disease, which received or not pre-surgery chemotherapy, entering a cryopreservation program. |
2019-05-01 |
2023-08-13 |
human |
| Xiaolu Zhang, Jing Liu, Yufeng Gu, Chengming Sun, Fuzheng Q. Down-regulation of lncRNA OGFRP1 induces autophagy and growth inhibition by AKT/mTOR signaling pathway in HCAECs. Cell biology international. vol 43. issue 2. 2019-04-30. PMID:30536541. |
the intrinsic apoptosis pathway was activated in lncrna ogfrp1 silenced cells, including increased bax and active-caspase 3 and decreased bcl2. |
2019-04-30 |
2023-08-13 |
human |
| Xi Zhang, Yuliang Pan, Huiqun Fu, Juan Zhan. microRNA-205 and microRNA-338-3p Reduces Cell Apoptosis in Prostate Carcinoma Tissue and LNCaP Prostate Carcinoma Cells by Directly Targeting the B-Cell Lymphoma 2 (Bcl-2) Gene. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2019-04-29. PMID:30741252. |
background the inhibitor of apoptosis, b-cell lymphoma 2 (bcl-2), is encoded by the bcl2 gene. |
2019-04-29 |
2023-08-13 |
human |
| Xi Zhang, Yuliang Pan, Huiqun Fu, Juan Zhan. microRNA-205 and microRNA-338-3p Reduces Cell Apoptosis in Prostate Carcinoma Tissue and LNCaP Prostate Carcinoma Cells by Directly Targeting the B-Cell Lymphoma 2 (Bcl-2) Gene. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2019-04-29. PMID:30741252. |
this study aimed to investigate the role of microrna-205 and microrna-338-3p and cell apoptosis in prostate carcinoma tissue and the lncap human prostate adenocarcinoma cell line by directly targeting the bcl2 gene and bcl-2 protein expression. |
2019-04-29 |
2023-08-13 |
human |
| Xi Zhang, Yuliang Pan, Huiqun Fu, Juan Zhan. microRNA-205 and microRNA-338-3p Reduces Cell Apoptosis in Prostate Carcinoma Tissue and LNCaP Prostate Carcinoma Cells by Directly Targeting the B-Cell Lymphoma 2 (Bcl-2) Gene. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2019-04-29. PMID:30741252. |
conclusions the results of this study showed that mir-205 and mir-338-3p downregulated the expression of the bcl2 gene and decreased apoptosis in prostate carcinoma. |
2019-04-29 |
2023-08-13 |
human |
| Sen Wang, Guanghui Zhao, Wanzhen Shao, Huan Liu, Weizhuo Wang, Cuiyan Wu, Mikko J Lammi, Xiong Gu. The Importance of Se-Related Genes in the Chondrocyte of Kashin-Beck Disease Revealed by Whole Genomic Microarray and Network Analysis. Biological trace element research. vol 187. issue 2. 2019-04-22. PMID:29948913. |
the se-related gene insulin-like growth factor binding protein 2 (igfbp2), insulin-like growth factor binding protein 3 (igfbp3), interleukin 6 (il6), bcl2, apoptosis regulator (bcl2), and bcl2-associated x, apoptosis regulator (bax), which involved in many molecular functions, biological processes, and apoptosis pathway may play important roles in the pathogenesis of kbd. |
2019-04-22 |
2023-08-13 |
Not clear |
| Yuqian Wang, Hong Zhao, Dezhou Wang, Miao Hao, Chenfei Kong, Xiaoming Zhao, Yiyao Gao, Jing Li, Baocai Liu, Bai Yang, Hao Zhang, Jinlan Jian. Inhibition of Autophagy Promoted Apoptosis and Suppressed Growth of Hepatocellular Carcinoma Upon Photothermal Exposure. Journal of biomedical nanotechnology. vol 15. issue 4. 2019-04-22. PMID:30841973. |
apoptosis was evaluated based on flow cytometry, western blot analysis of apoptosis related proteins (bax, bcl2, caspase 3), hoechst staining, and tunel staining. |
2019-04-22 |
2023-08-13 |
Not clear |
| A Štern, A Rotter, M Novak, M Filipič, B Žegur. Genotoxic effects of the cyanobacterial pentapeptide nodularin in HepG2 cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 124. 2019-04-18. PMID:30562542. |
moreover changes in the expression of selected genes from the p53 pathway, involved in the response to dna damage (p53, gadd45α, cdkn1a, mdm2), apoptosis (bax, bcl2) and oxidative stress (gpx1, gsr, gclc, cat, sod1) were determined using qpcr. |
2019-04-18 |
2023-08-13 |
human |
| Aline D de Araujo, Junxian Lim, Kai-Chen Wu, Yibin Xiang, Andrew C Good, Renato Skerlj, David P Fairli. Bicyclic Helical Peptides as Dual Inhibitors Selective for Bcl2A1 and Mcl-1 Proteins. Journal of medicinal chemistry. vol 61. issue 7. 2019-04-17. PMID:29584430. |
a 26-residue peptide bimbh3 binds indiscriminately to multiple oncogenic bcl2 proteins that regulate apoptosis of cancer cells. |
2019-04-17 |
2023-08-13 |
human |
| Eleonora Maurizi, Davide Schiroli, Sarah D Atkinson, Laura Mairs, David G Courtney, Barry O'Hagan, Victoria E McGilligan, Alastair T Pagnamenta, Jenny C Taylor, Jesus J D Vasquez, Daniel E Illanes-Velarde, Dave Goldsmith, Pieter Gouws, Jonathan E Moore, M Andrew Nesbit, C B Tara Moor. A novel role for CRIM1 in the corneal response to UV and pterygium development. Experimental eye research. vol 179. 2019-04-15. PMID:30365943. |
transient expression of the mutant h412p crim1 in corneal epithelial hce-s cells showed that, unlike wild-type crim1, it was unable to reduce the cell proliferation, increased erk phosphorylation and apoptosis induced through a decrease of bcl2 expression levels. |
2019-04-15 |
2023-08-13 |
Not clear |
| Abu Musa Md Talimur Reza, Yun-Jung Choi, Yu-Guo Yuan, Joydeep Das, Hideyo Yasuda, Jin-Hoi Ki. MicroRNA-7641 is a regulator of ribosomal proteins and a promising targeting factor to improve the efficacy of cancer therapy. Scientific reports. vol 7. issue 1. 2019-04-03. PMID:28827731. |
in addition, inhibition of mir-7641 boosted doxorubicin-mediated apoptosis of cancer cells via upregulation of apoptotic molecules caspase 9 (cas9) and poly adp ribose polymerase (parp) and downregulation of anti-apoptotic molecule bcl2. |
2019-04-03 |
2023-08-13 |
Not clear |
| Yong Cui, Yan Su, Liya Deng, Wenjing Wan. Ginsenoside-Rg5 Inhibits Retinoblastoma Proliferation and Induces Apoptosis through Suppressing BCL2 Expression. Chemotherapy. vol 63. issue 5. 2019-03-26. PMID:30731458. |
ginsenoside-rg5 inhibits retinoblastoma proliferation and induces apoptosis through suppressing bcl2 expression. |
2019-03-26 |
2023-08-13 |
Not clear |