| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xi Zhang, Yuliang Pan, Huiqun Fu, Juan Zhan. microRNA-205 and microRNA-338-3p Reduces Cell Apoptosis in Prostate Carcinoma Tissue and LNCaP Prostate Carcinoma Cells by Directly Targeting the B-Cell Lymphoma 2 (Bcl-2) Gene. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2019-04-29. PMID:30741252. |
this study aimed to investigate the role of microrna-205 and microrna-338-3p and cell apoptosis in prostate carcinoma tissue and the lncap human prostate adenocarcinoma cell line by directly targeting the bcl2 gene and bcl-2 protein expression. |
2019-04-29 |
2023-08-13 |
human |
| Xi Zhang, Yuliang Pan, Huiqun Fu, Juan Zhan. microRNA-205 and microRNA-338-3p Reduces Cell Apoptosis in Prostate Carcinoma Tissue and LNCaP Prostate Carcinoma Cells by Directly Targeting the B-Cell Lymphoma 2 (Bcl-2) Gene. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2019-04-29. PMID:30741252. |
conclusions the results of this study showed that mir-205 and mir-338-3p downregulated the expression of the bcl2 gene and decreased apoptosis in prostate carcinoma. |
2019-04-29 |
2023-08-13 |
human |
| Sen Wang, Guanghui Zhao, Wanzhen Shao, Huan Liu, Weizhuo Wang, Cuiyan Wu, Mikko J Lammi, Xiong Gu. The Importance of Se-Related Genes in the Chondrocyte of Kashin-Beck Disease Revealed by Whole Genomic Microarray and Network Analysis. Biological trace element research. vol 187. issue 2. 2019-04-22. PMID:29948913. |
the se-related gene insulin-like growth factor binding protein 2 (igfbp2), insulin-like growth factor binding protein 3 (igfbp3), interleukin 6 (il6), bcl2, apoptosis regulator (bcl2), and bcl2-associated x, apoptosis regulator (bax), which involved in many molecular functions, biological processes, and apoptosis pathway may play important roles in the pathogenesis of kbd. |
2019-04-22 |
2023-08-13 |
Not clear |
| Yuqian Wang, Hong Zhao, Dezhou Wang, Miao Hao, Chenfei Kong, Xiaoming Zhao, Yiyao Gao, Jing Li, Baocai Liu, Bai Yang, Hao Zhang, Jinlan Jian. Inhibition of Autophagy Promoted Apoptosis and Suppressed Growth of Hepatocellular Carcinoma Upon Photothermal Exposure. Journal of biomedical nanotechnology. vol 15. issue 4. 2019-04-22. PMID:30841973. |
apoptosis was evaluated based on flow cytometry, western blot analysis of apoptosis related proteins (bax, bcl2, caspase 3), hoechst staining, and tunel staining. |
2019-04-22 |
2023-08-13 |
Not clear |
| A Štern, A Rotter, M Novak, M Filipič, B Žegur. Genotoxic effects of the cyanobacterial pentapeptide nodularin in HepG2 cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 124. 2019-04-18. PMID:30562542. |
moreover changes in the expression of selected genes from the p53 pathway, involved in the response to dna damage (p53, gadd45α, cdkn1a, mdm2), apoptosis (bax, bcl2) and oxidative stress (gpx1, gsr, gclc, cat, sod1) were determined using qpcr. |
2019-04-18 |
2023-08-13 |
human |
| Aline D de Araujo, Junxian Lim, Kai-Chen Wu, Yibin Xiang, Andrew C Good, Renato Skerlj, David P Fairli. Bicyclic Helical Peptides as Dual Inhibitors Selective for Bcl2A1 and Mcl-1 Proteins. Journal of medicinal chemistry. vol 61. issue 7. 2019-04-17. PMID:29584430. |
a 26-residue peptide bimbh3 binds indiscriminately to multiple oncogenic bcl2 proteins that regulate apoptosis of cancer cells. |
2019-04-17 |
2023-08-13 |
human |
| Eleonora Maurizi, Davide Schiroli, Sarah D Atkinson, Laura Mairs, David G Courtney, Barry O'Hagan, Victoria E McGilligan, Alastair T Pagnamenta, Jenny C Taylor, Jesus J D Vasquez, Daniel E Illanes-Velarde, Dave Goldsmith, Pieter Gouws, Jonathan E Moore, M Andrew Nesbit, C B Tara Moor. A novel role for CRIM1 in the corneal response to UV and pterygium development. Experimental eye research. vol 179. 2019-04-15. PMID:30365943. |
transient expression of the mutant h412p crim1 in corneal epithelial hce-s cells showed that, unlike wild-type crim1, it was unable to reduce the cell proliferation, increased erk phosphorylation and apoptosis induced through a decrease of bcl2 expression levels. |
2019-04-15 |
2023-08-13 |
Not clear |
| Abu Musa Md Talimur Reza, Yun-Jung Choi, Yu-Guo Yuan, Joydeep Das, Hideyo Yasuda, Jin-Hoi Ki. MicroRNA-7641 is a regulator of ribosomal proteins and a promising targeting factor to improve the efficacy of cancer therapy. Scientific reports. vol 7. issue 1. 2019-04-03. PMID:28827731. |
in addition, inhibition of mir-7641 boosted doxorubicin-mediated apoptosis of cancer cells via upregulation of apoptotic molecules caspase 9 (cas9) and poly adp ribose polymerase (parp) and downregulation of anti-apoptotic molecule bcl2. |
2019-04-03 |
2023-08-13 |
Not clear |
| Yong Cui, Yan Su, Liya Deng, Wenjing Wan. Ginsenoside-Rg5 Inhibits Retinoblastoma Proliferation and Induces Apoptosis through Suppressing BCL2 Expression. Chemotherapy. vol 63. issue 5. 2019-03-26. PMID:30731458. |
ginsenoside-rg5 inhibits retinoblastoma proliferation and induces apoptosis through suppressing bcl2 expression. |
2019-03-26 |
2023-08-13 |
Not clear |
| Sri Renukadevi Balusamy, Haribalan Perumalsamy, Md Amdad Huq, Balamuralikrishnan Balasubramania. Anti-proliferative activity of Origanum vulgare inhibited lipogenesis and induced mitochondrial mediated apoptosis in human stomach cancer cell lines. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 108. 2019-03-18. PMID:30372889. |
the increase of bax expression and downregulation of bcl2 expression indicated that oregano eo induced mitochondrial mediated apoptosis. |
2019-03-18 |
2023-08-13 |
human |
| Banudevi Sivanantham, UmaMaheswari Krishnan, Vignesh Rajendira. Amelioration of oxidative stress in differentiated neuronal cells by rutin regulated by a concentration switch. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 108. 2019-03-14. PMID:30212708. |
the study showed that the high (100 μm) and low (100 nm and 10μm) rutin concentrations significantly avert ros generation by two different mechanisms, by enhancing apoptosis through the modulation of levels of bcl2, caspase-3, survivin and its antioxidant activity via stress-related proteins, jnk and p38 mapk. |
2019-03-14 |
2023-08-13 |
human |
| Wan Wang, Di Wen, Weisong Duan, Juntao Yin, Can Cui, Ying Wang, Zhongyao Li, Yakun Liu, Chunyan L. Systemic administration of scAAV9-IGF1 extends survival in SOD1 Brain research bulletin. vol 139. 2019-03-12. PMID:29499331. |
furthermore, we detected the levels of proteins involved in the apoptosis pathway and found that the apoptotic inhibitor bcl2 increased and the apoptotic promoter bax, caspase 3, and caspase 9 decreased. |
2019-03-12 |
2023-08-13 |
mouse |
| Bruno Martinucci, Brenda de Carvalho Minatel, Maira Smaniotto Cucielo, Mariana Medeiros, Ivan José Vechetti-Junior, Sérgio Luis Felisbino, Flávia Karina Delell. Basement membrane extract attenuates the more malignant gene expression profile accentuated by fibronectin in prostate cancer cells. Molecular and cellular biochemistry. vol 451. issue 1-2. 2019-03-08. PMID:29961211. |
when fn was the predominant matrix element, such as in blood plasma, pca tumor cells increased their expression of genes related to an invasive behavior and resistance to apoptosis, including cdh2, itga5, akt1, and bcl2. |
2019-03-08 |
2023-08-13 |
Not clear |
| Dan Li, Gangcheng Wang, Guoguo Jin, Ke Yao, Zhenjiang Zhao, Liangyu Bie, Yongjun Guo, Ning Li, Wenying Deng, Xiaobin Chen, Beibei Chen, Yuanyuan Liu, Suxia Luo, Zhiping Gu. Resveratrol suppresses colon cancer growth by targeting the AKT/STAT3 signaling pathway. International journal of molecular medicine. vol 43. issue 1. 2019-03-05. PMID:30387805. |
additionally, resveratrol treatment decreased the protein expression levels of cyclin d1, cyclin e2 and bcl2 apoptosis regulator, while it increased bcl2 associated x and tumor protein p53, all of which are involved in the regulation of cell cycle and apoptosis. |
2019-03-05 |
2023-08-13 |
Not clear |
| Riccardo Moia, Fary Diop, Chiara Favini, Ahad Ahmed Kodipad, Gianluca Gaidan. Potential of BCL2 as a target for chronic lymphocytic leukemia treatment. Expert review of hematology. vol 11. issue 5. 2019-02-28. PMID:29561706. |
areas covered: this article covers the biology of apoptosis in cll from a translational viewpoint and deals with the mode of action of bcl2 inhibitors, in particular venetoclax. |
2019-02-28 |
2023-08-13 |
Not clear |
| Emanuel Candeias, Inês Sebastião, Susana Cardoso, Cristina Carvalho, Maria Sancha Santos, Catarina Resende Oliveira, Paula I Moreira, Ana I Duart. Brain GLP-1/IGF-1 Signaling and Autophagy Mediate Exendin-4 Protection Against Apoptosis in Type 2 Diabetic Rats. Molecular neurobiology. vol 55. issue 5. 2019-02-26. PMID:28573460. |
moreover, ex-4 regulated several markers for autophagy in gk rat brains (as mtor, pi3k class iii, lc3 ii, atg7, p62, lamp-1, and parkin), ultimately protecting against apoptosis (by decreasing several caspase-like activities and mitochondrial cytochrome c, and increasing bcl2 levels upon t2d). |
2019-02-26 |
2023-08-13 |
rat |
| Hector Mesa, Wendy Larson, Juan C Manive. Acquired adenomatous hyperplasia of the rete testis: an immunohistochemical study of its pathogenesis. Human pathology. vol 73. 2019-02-13. PMID:28970137. |
we performed immunohistochemical studies using markers of cell cycle (cyclin d1, p16), proliferation (ki-67), apoptosis (bcl2), senescence (γ-h2ax), and androgen receptors to try to provide scientific support for or refute existing hypotheses. |
2019-02-13 |
2023-08-13 |
Not clear |
| Yuanzhi Zhao, Cong Zhou, Hang Yu, Wenwu Zhang, Fang Cheng, Haihang Yu, Dongsheng Zhou, Bin Li, Jing Liu, Jie Dai, Jie Zhong, Min Chen, Tianyi Huang, Ranran Pan, Shiwei Duan, Zhenyu H. Association between the methylation of six apoptosis‑associated genes with autism spectrum disorder. Molecular medicine reports. vol 18. issue 5. 2019-02-12. PMID:30221723. |
the aim of the present study was to investigate the association between the methylation of six apoptosis‑associated genes [transforming growth factor β 1 (tgfb1), bcl2 associated x, apoptosis regulator, insulin like growth factor binding protein 3, protein kinase c β 1, presenilin 2 and c‑c motif chemokine ligand 2] and asd. |
2019-02-12 |
2023-08-13 |
human |
| R S Redman, E Paal, S Chauhan, R Avers, N Bayle. Botryoid odontogenic cyst. Exploration of proliferative activity, apoptosis and expression of TP53 and BCL2 compared to the histologically identical lateral periodontal and gingival cysts. Biotechnic & histochemistry : official publication of the Biological Stain Commission. vol 92. issue 8. 2019-02-08. PMID:28910164. |
exploration of proliferative activity, apoptosis and expression of tp53 and bcl2 compared to the histologically identical lateral periodontal and gingival cysts. |
2019-02-08 |
2023-08-13 |
Not clear |
| R S Redman, E Paal, S Chauhan, R Avers, N Bayle. Botryoid odontogenic cyst. Exploration of proliferative activity, apoptosis and expression of TP53 and BCL2 compared to the histologically identical lateral periodontal and gingival cysts. Biotechnic & histochemistry : official publication of the Biological Stain Commission. vol 92. issue 8. 2019-02-08. PMID:28910164. |
sections of neutral buffered formalin fixed, paraffin-embedded tissues from the boc and archival specimens of four gcs, four lpcs and three odontogenic keratocysts (okcs) were stained using immunohistochemistry for ki-67, a marker of proliferating cells, caspase-3, a marker of cells undergoing apoptosis, tumor suppressor p53, and the apoptosis inhibitor bcl2. |
2019-02-08 |
2023-08-13 |
Not clear |