| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hongge Li, Yingyu Mao, Michael Bouaziz, Honglian Yu, Xiuxia Qu, Fen Wang, Gen-Sheng Feng, Carrie Shawber, Xin Zhan. Lens differentiation is controlled by the balance between PDGF and FGF signaling. PLoS biology. vol 17. issue 2. 2019-11-05. PMID:30716082. |
activation of pi3k signaling not only prevents b-cell lymphoma 2 (bcl2)-associated x (bax)- and bcl2 antagonist/killer (bak)-mediated apoptosis but also promotes notch signaling to prevent premature cell differentiation. |
2019-11-05 |
2023-08-13 |
Not clear |
| Zofia E Madeja, Ewelina Warzych, Piotr Pawlak, Dorota Lechnia. Inhibitor mediated WNT and MEK/ERK signalling affects apoptosis and the expression of quality related genes in bovine in vitro obtained blastocysts. Biochemical and biophysical research communications. vol 510. issue 3. 2019-11-04. PMID:30711254. |
a higher rate of apoptosis was observed in 2i blastocysts, but was not accompanied by changes in transcript content of genes controlling apoptosis (bax, bcl2, bak, bax/bcl2 ratio). |
2019-11-04 |
2023-08-13 |
cattle |
| A M Hassanin, H H Ahmed, A N Kadda. A global view of the pathophysiology of varicocele. Andrology. vol 6. issue 5. 2019-10-28. PMID:29978951. |
the genetic role should not be overlooked as a contributing factor in the induction of heat stress, excess reactive oxygen species/oxidative stress, and apoptosis; this is evidenced by the association of varicocele with decreased expression of heat-shock proteins, higher polymorphism of glutathione s transferase and nitric oxide synthase genes, and increased bax and decreased bcl2 genes and proteins. |
2019-10-28 |
2023-08-13 |
Not clear |
| Kaneez Fatima, Shilu Mathew, Muhammed Faheem, Tahir Mehmood, Hadi Mohamad Yassine, Asmaa A Al Thani, Hany Abdel-Hafiz, Khalid Al Ghamdy, Ishtiaq Qadr. The Dual Specificity Role of Transcription Factor FOXO in Type 2-diabetes and Cancer. Current pharmaceutical design. vol 24. issue 24. 2019-10-28. PMID:30205794. |
the foxo3 is a tumor suppressor gene and found to interact with p53, the trigger for apoptosis through bcl2 family genes and a regulator of notch signaling pathway for the self-renewal of stem cells. |
2019-10-28 |
2023-08-13 |
Not clear |
| Mayank Choubey, Ashutosh Ranjan, Puran S Bora, Fátima Baltazar, Amitabh Krishn. Direct actions of adiponectin on changes in reproductive, metabolic, and anti-oxidative enzymes status in the testis of adult mice. General and comparative endocrinology. vol 279. 2019-10-24. PMID:29908833. |
the result of the in vitro study showed the direct action of adiponectin on spermatogenesis by stimulating cell proliferation (pcna) and survival (bcl2) and by suppressing cell apoptosis. |
2019-10-24 |
2023-08-13 |
mouse |
| Partha S Chowdhury, Kenji Chamoto, Alok Kumar, Tasuku Honj. PPAR-Induced Fatty Acid Oxidation in T Cells Increases the Number of Tumor-Reactive CD8 Cancer immunology research. vol 6. issue 11. 2019-10-22. PMID:30143538. |
cpt1 and bcl2 can form a complex to prevent apoptosis of ctls. |
2019-10-22 |
2023-08-13 |
mouse |
| Raphael Koch, Amanda L Christie, Jennifer L Crombie, Adam C Palmer, Deborah Plana, Kay Shigemori, Sara N Morrow, Alexandria Van Scoyk, Wenchao Wu, Elizabeth A Brem, J Paul Secrist, Lisa Drew, Alwin G Schuller, Justin Cidado, Anthony Letai, David M Weinstoc. Biomarker-driven strategy for MCL1 inhibition in T-cell lymphomas. Blood. vol 133. issue 6. 2019-10-18. PMID:30498064. |
we characterized the mitochondrial apoptosis pathway in cell lines and patient-derived xenograft (pdx) models of tcl and assessed the in vitro efficacy of bh3 mimetics, including the bcl2 inhibitor venetoclax, the bcl2/bcl-xl inhibitor navitoclax, and the novel mcl1 inhibitor azd5991. |
2019-10-18 |
2023-08-13 |
mouse |
| Xiaoyou Li, Xia Zhao, Chenchen Li, Siwen Liu, Fei Yan, Yue Teng, Jifeng Feng, Dengshun Mia. Inhibitor of ghrelin receptor reverses gefitinib resistance in lung cancer. Human cell. vol 32. issue 3. 2019-10-18. PMID:31020605. |
in h1650 and hcc827/gr cells, combination of d-lys-3-ghrp-6 and gefitinib significantly inhibited cell proliferation and bcl2 protein level, induced the cell apoptosis and cleaved-caspase3 protein level compared with control group, while there was no significant difference between control and gefitinib group. |
2019-10-18 |
2023-08-13 |
human |
| Maryam Hormozi, Shadi Ghoreishi, Parasto Baharvan. Astaxanthin induces apoptosis and increases activity of antioxidant enzymes in LS-180 cells. Artificial cells, nanomedicine, and biotechnology. vol 47. issue 1. 2019-10-17. PMID:30873887. |
the results showed that astaxanthin increases the expression of bax and caspase3 genes and decreases that of bcl2, thereby, inducing apoptosis and inhibiting growth and proliferation of the cells. |
2019-10-17 |
2023-08-13 |
Not clear |
| Maryam Farzaneh Behelgardi, Saber Zahri, Farhad Mashayekhi, Kamran Mansouri, S Mohsen Asghar. A peptide mimicking the binding sites of VEGF-A and VEGF-B inhibits VEGFR-1/-2 driven angiogenesis, tumor growth and metastasis. Scientific reports. vol 8. issue 1. 2019-10-15. PMID:30560942. |
administration of vgb4 led to the regression of 4t1 murine mct growth through decreased expression of p-vegfr1 and p-vegfr2 and abrogation of erk1/2 and akt activation followed by considerable decrease of tumor cell proliferation (ki67 expression) and angiogenesis (cd31 and cd34 expression), induction of apoptosis (increased p53 expression, tunel staining and decreased bcl2 expression), and suppression of metastasis (increased e-cadherin and decreased n-cadherin, nf-κb and mmp-9 expression). |
2019-10-15 |
2023-08-13 |
human |
| Reema Singh, Priyanka Chaudhary, Ranjana Ary. Role of IGF-1R in ameliorating apoptosis of GNE deficient cells. Scientific reports. vol 8. issue 1. 2019-10-09. PMID:29743626. |
igf-1 induced activation of igf-1r led to akt (protein kinase b) phosphorylation that may phosphorylate bad (bcl2 associated death promoter) and its dissociation from bcl2 to prevent apoptosis. |
2019-10-09 |
2023-08-13 |
Not clear |
| Jia Liu, Weijin Liu, Yongquan Lu, Hao Tian, Chunli Duan, Lingling Lu, Ge Gao, Xia Wu, Xiaomin Wang, Hui Yan. Piperlongumine restores the balance of autophagy and apoptosis by increasing BCL2 phosphorylation in rotenone-induced Parkinson disease models. Autophagy. vol 14. issue 5. 2019-10-03. PMID:29433359. |
piperlongumine restores the balance of autophagy and apoptosis by increasing bcl2 phosphorylation in rotenone-induced parkinson disease models. |
2019-10-03 |
2023-08-13 |
mouse |
| Jia Liu, Weijin Liu, Yongquan Lu, Hao Tian, Chunli Duan, Lingling Lu, Ge Gao, Xia Wu, Xiaomin Wang, Hui Yan. Piperlongumine restores the balance of autophagy and apoptosis by increasing BCL2 phosphorylation in rotenone-induced Parkinson disease models. Autophagy. vol 14. issue 5. 2019-10-03. PMID:29433359. |
these protective effects were exerted via inhibition of apoptosis and induction of autophagy through enhancement of bcl2 phosphorylation at ser70. |
2019-10-03 |
2023-08-13 |
mouse |
| Ning Ding, Chuan Liu, Li Yao, Yun Bai, Peng Cheng, Zhilin Li, Keyu Luo, Tieniu Mei, Jianhua Li, Junchao Xing, Xiaoliang Gao, Qinyu Ma, Jianzhong Xu, Fei Luo, Ce Do. Alendronate induces osteoclast precursor apoptosis via peroxisomal dysfunction mediated ER stress. Journal of cellular physiology. vol 233. issue 9. 2019-09-30. PMID:29600563. |
peroxisomal dysfunction further induced endoplasmic reticulum (er) stress in pocs and finally resulted in cell apoptosis marked by reduced expression of b-cell lymphoma 2 (bcl-2) and increased expressions of ccaat/enhancer binding protein homologous protein (chop), bcl2 associated x (bax), and cleaved caspase-3. |
2019-09-30 |
2023-08-13 |
mouse |
| Fevzi F Yalniz, William G Wierd. Targeting BCL2 in Chronic Lymphocytic Leukemia and Other Hematologic Malignancies. Drugs. vol 79. issue 12. 2019-09-27. PMID:31313099. |
members of the b-cell lymphoma 2 (bcl2) family of proteins are central regulators of apoptosis, and resistance to apoptosis is one of the hallmarks of cancer. |
2019-09-27 |
2023-08-13 |
Not clear |
| Kazem Zibara, Asad Zeidan, Khalil Mallah, Nouhad Kassem, Ali Awad, Frédéric Mazurier, Bassam Badran, Nabil El-Zei. Signaling pathways activated by PACAP in MCF-7 breast cancer cells. Cellular signalling. vol 50. 2019-09-17. PMID:29935235. |
finally, pacap stimulation promoted apoptosis by increasing bax and decreasing bcl2 expression. |
2019-09-17 |
2023-08-13 |
human |
| Brian Leber, Justin Kale, David W Andrew. Unleashing Blocked Apoptosis in Cancer Cells: New MCL1 Inhibitors Find Their Groove. Cancer discovery. vol 8. issue 12. 2019-09-12. PMID:30510014. |
unleashing blocked apoptosis has emerged as an important tool in treating cancer as shown by the recent success of the bcl2 inhibitor venetoclax. |
2019-09-12 |
2023-08-13 |
Not clear |
| James N Tsoporis, Anastasia Fazio, Ioannis K Rizos, Shehla Izhar, Gerald Proteau, Vasileos Salpeas, Angelos Rigopoulos, Eleftherios Sakadakis, Ioannis K Toumpoulis, Thomas G Parke. Increased right atrial appendage apoptosis is associated with differential regulation of candidate MicroRNAs 1 and 133A in patients who developed atrial fibrillation after cardiac surgery. Journal of molecular and cellular cardiology. vol 121. 2019-09-10. PMID:29885959. |
we examined the levels of the muscle-specific mirs 1 and 133a and markers of apoptosis including tunel staining, caspase-3 activation, bcl2 and bax mrnas in right atrial appendage (raa) biopsies and blood plasma taken before aortic cross-clamping and after reperfusion. |
2019-09-10 |
2023-08-13 |
rat |
| Hongyi Zhang, Kebing Xiao, Ganggang Zhao, Huafeng Li, Jie Cu. [Knock-down of leucine-rich pentatricopeptide repeat containing(LRPPRC) promotes apoptosis of hormone resistant prostate cancer cells]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 35. issue 5. 2019-09-05. PMID:31223111. |
down-regulation of lrpprc decreased cell survival rate and atp level, increased apoptosis rate and caspase-3 activation, and decreased bcl2 expression in du145 cells. |
2019-09-05 |
2023-08-13 |
Not clear |
| Kaviyarasi Renu, Abilash Valsala Gopalakrishna. Deciphering the molecular mechanism during doxorubicin-mediated oxidative stress, apoptosis through Nrf2 and PGC-1α in a rat testicular milieu. Reproductive biology. vol 19. issue 1. 2019-09-04. PMID:30827825. |
apoptosis become found through dna fragmentation assay and quantification of caspase 3, caspase 9, bcl2 and cytochrome c. doxorubicin mediated oxidative stress and apoptosis in testicular milieu is through deregulation of nrf2, pgc-1α, ahr, arnt, pxr, sumo-1, ucp2, ucp3, anx a5, caspase 3, caspase 9, bcl2, cytochrome c, gr, and gpx. |
2019-09-04 |
2023-08-13 |
rat |