| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yi Li, Jinying Lu, Furong Bai, Yanan Xiao, Yiran Guo, Ziming Don. Ginsenoside Rg3 Suppresses Proliferation and Induces Apoptosis in Human Osteosarcoma. BioMed research international. vol 2018. 2018-09-28. PMID:29750154. |
therefore, we hypothesized rg3 inhibits the proliferation of osteosarcoma cell line and induces their apoptosis by affecting apoptosis-related genes (bcl2, caspase3) as well as the pi3k/akt/mtor signaling pathway. |
2018-09-28 |
2023-08-13 |
human |
| Keyan Chen, Wei Chen, Shi Li Liu, Tian Shi Wu, Kai Feng Yu, Jing Qi, Yijun Wang, Hui Yao, Xiao Yang Huang, Ying Han, Ping Ho. Epigallocatechingallate attenuates myocardial injury in a mouse model of heart failure through TGF‑β1/Smad3 signaling pathway. Molecular medicine reports. vol 17. issue 6. 2018-09-26. PMID:29620209. |
transforming growth factor‑β1 (tgf‑β1), smad3, phosphorylated (p)‑smad3, apoptosis regulator bax (bax), caspase‑3 and apoptosis regulator bcl2 in mouse cardiac tissue were measured by western blotting. |
2018-09-26 |
2023-08-13 |
mouse |
| Heng Fan, Jian-Hua Zhu, Xue-Qing Ya. Knockdown of long non‑coding RNA PVT1 reverses multidrug resistance in colorectal cancer cells. Molecular medicine reports. vol 17. issue 6. 2018-09-26. PMID:29693171. |
rt‑qpcr and western blotting demonstrated that the overexpression of pvt1 increased the mrna and protein expression levels of multidrug resistance‑associated protein 1, p‑glycoprotein, serine/threonine‑protein kinase mtor and apoptosis regulator bcl2. |
2018-09-26 |
2023-08-13 |
Not clear |
| Jin-Ah Kim, Ying Tan, Xian Wang, Xixi Cao, Jamunarani Veeraraghavan, Yulong Liang, Dean P Edwards, Shixia Huang, Xuewen Pan, Kaiyi Li, Rachel Schiff, Xiao-Song Wan. Comprehensive functional analysis of the tousled-like kinase 2 frequently amplified in aggressive luminal breast cancers. Nature communications. vol 7. 2018-09-25. PMID:27694828. |
conversely, tlk2 inhibition selectively inhibits the growth of tlk2-high breast cancer cells, downregulates erα, bcl2 and skp2, impairs g1/s cell cycle progression, induces apoptosis and significantly improves progression-free survival in vivo. |
2018-09-25 |
2023-08-13 |
Not clear |
| Linyu Zhou, Chunyan Bao, Xiao Hu, Yongqing Dai, Zhijun Ba. [LRIG1 promotes the apoptosis of pituitary tumor cells induced by cisplatin]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 34. issue 1. 2018-09-20. PMID:29595451. |
the cells of the two groups were induced by 20 g/ml ddp, and 48 hours later, the cell apoptosis was detected by flow cytometry; the proliferation capacity was tested by plate cloning experiment; and the relative expressions of apoptosis-related proteins bax, caspase-3 and bcl2 in the cells were examined by western blot analysis. |
2018-09-20 |
2023-08-13 |
human |
| Linyu Zhou, Chunyan Bao, Xiao Hu, Yongqing Dai, Zhijun Ba. [LRIG1 promotes the apoptosis of pituitary tumor cells induced by cisplatin]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 34. issue 1. 2018-09-20. PMID:29595451. |
compared with the control group, after lrig1 was over-expressed, the cell apoptosis rate significantly increased, the cell proliferation significantly decreased, and the levels of bax and caspase-3 increased as well, while the level of bcl2 decreased remarkably. |
2018-09-20 |
2023-08-13 |
human |
| Kuo-Shyang Jeng, Chi-Juei Jeng, I-Shyan Sheen, Szu-Hua Wu, Ssu-Jung Lu, Chih-Hsuan Wang, Chiung-Fang Chan. Glioma-Associated Oncogene Homolog Inhibitors Have the Potential of Suppressing Cancer Stem Cells of Breast Cancer. International journal of molecular sciences. vol 19. issue 5. 2018-09-20. PMID:29734730. |
it reduced bcl2 expression for cell proliferation and increased bim expression for apoptosis. |
2018-09-20 |
2023-08-13 |
human |
| Mariah Tolbert, Sheree J Finley, Silvia D Visonà, Shivani Soni, Antonio Osculati, Gulnaz T Java. The thanatotranscriptome: Gene expression of male reproductive organs after death. Gene. vol 675. 2018-09-20. PMID:30180965. |
the expression of anti-apoptotic genes such as bag1, bcl2, and negative regulator of apoptosis, xiap, was significantly elevated in a time-dependent manner. |
2018-09-20 |
2023-08-13 |
human |
| Moureq R Alotaibi, Zeinab K Hassan, Salim S Al-Rejaie, Musaad A Alshammari, Mashal M Almutairi, Ali R Alhoshani, Wael A Alanazi, Mohamed M Hafez, Othman A Al-Shabana. Characterization of Apoptosis in a Breast Cancer Cell Line after IL-10 Silencing Asian Pacific journal of cancer prevention : APJCP. vol 19. issue 3. 2018-09-19. PMID:29582634. |
results: inhibition of il-10 by the sirna accelerated apoptosis and was accompanied by significantincrease in caspase-3 and caspase-9 and a significant decrease in pi3k, akt and bcl2 expression levels compared tothe non-transfected case. |
2018-09-19 |
2023-08-13 |
Not clear |
| Yan Li, Haixu Wang, Dangxia Zhou, Ting Shuang, Haibo Zhao, Biliang Che. Up-Regulation of Long Noncoding RNA SRA Promotes Cell Growth, Inhibits Cell Apoptosis, and Induces Secretion of Estradiol and Progesterone in Ovarian Granular Cells of Mice. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2018-09-18. PMID:29674607. |
results we demonstrated that elevated lncrna sra stimulated cell growth, changed distribution of cell cycle phases with increase of cyclin b, cyclin e, and cyclin d1, and inhibited cell apoptosis with up-regulation of bcl2 and down-regulation of bax, cleaved-caspase 3, and cleaved-parp. |
2018-09-18 |
2023-08-13 |
mouse |
| Subhadip Hajra, Arup Ranjan Patra, Abhishek Basu, Sudin Bhattachary. Prevention of doxorubicin (DOX)-induced genotoxicity and cardiotoxicity: Effect of plant derived small molecule indole-3-carbinol (I3C) on oxidative stress and inflammation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 101. 2018-09-13. PMID:29494960. |
moreover, i3c attenuate dox-induced apoptosis by up-regulation of bcl2 and down-regulation of bax and caspase-3 expression in bone marrow cells. |
2018-09-13 |
2023-08-13 |
mouse |
| Yahima Frión-Herrera, Alexis Díaz-García, Jenny Ruiz-Fuentes, Hermis Rodríguez-Sánchez, José Maurício Sforci. Mechanisms underlying the cytotoxic effect of propolis on human laryngeal epidermoid carcinoma cells. Natural product research. vol 32. issue 17. 2018-09-11. PMID:28783983. |
both samples induced apoptosis via activation of tp53, casp3, bax, p21 signalling, and downregulation of bcl2 and bcl-xl. |
2018-09-11 |
2023-08-13 |
human |
| Bahadir Batar, Tuba Mutlu, Merve Bostanci, Mustafa Akin, Matem Tuncdemir, Nuran Bese, Mehmet Guve. DNA repair and apoptosis: Roles in radiotherapy-related acute reactions in breast cancer patients. Cellular and molecular biology (Noisy-le-Grand, France). vol 64. issue 4. 2018-09-11. PMID:29631685. |
our aim was to define the association of dna repair (ercc1 and xpc) and apoptotic (bcl2, casp3 and nfkb1) gene expression, dna damage levels, apoptosis changes and dna repair gene variations with the risk of acute side effects in breast cancer patients. |
2018-09-11 |
2023-08-13 |
Not clear |
| Jie Yuan, Xueyan Zhao, Yujuan Hu, Haiying Sun, Guoqing Gong, Xiang Huang, Xubo Chen, Mingyu Xia, Chen Sun, Qilin Huang, Yu Sun, Wen Kong, Weijia Kon. Autophagy regulates the degeneration of the auditory cortex through the AMPK-mTOR-ULK1 signaling pathway. International journal of molecular medicine. vol 41. issue 4. 2018-08-29. PMID:29344647. |
however, lc3, becn1, bcl2 and bcl‑xl were decreased at 15 months in the d-gal group, with cell apoptosis significantly increased and substantial neuron degeneration. |
2018-08-29 |
2023-08-13 |
rat |
| Antonio Piras, Lorenzo Schiaffino, Marina Boido, Valeria Valsecchi, Michela Guglielmotto, Elena De Amicis, Julien Puyal, Ana Garcera, Elena Tamagno, Rosa M Soler, Alessandro Vercell. Inhibition of autophagy delays motoneuron degeneration and extends lifespan in a mouse model of spinal muscular atrophy. Cell death & disease. vol 8. issue 12. 2018-08-27. PMID:29259166. |
inhibition of autophagy by 3-ma suppressed autophagosome formation, reduced the apoptotic activation (cleaved caspase-3 and bcl2) and the appearance of terminal deoxynucleotidyl transferase dutp nick end labeling (tunel)-positive neurons, underlining that apoptosis and autophagy pathways are intricately intertwined. |
2018-08-27 |
2023-08-13 |
mouse |
| Hui-Zhen Zheng, Xue-Kun Fu, Jiu-Long Shang, Rong-Xi Lu, Yong-Fang Ou, Chun-Ling Che. Ginsenoside Rg1 protects rat bone marrow mesenchymal stem cells against ischemia induced apoptosis through miR-494-3p and ROCK-1. European journal of pharmacology. vol 822. 2018-08-20. PMID:29307726. |
rbmscs treated with hypoxia and serum deprivation for 24h (h/sd-rbmscs) showed the up-regulated expression of ras homolog family member a (rhoa), rho associated coiled-coil containing protein kinase 1 (rock-1), myosin light chain 2 (mlc-2), bcl2 associated agonist of cell death (bad) and bcl2 associated x, apoptosis regulator (bax); while the expression of mir-148b-3p, mir-148b-5p and mir-494-3p was down-regulated. |
2018-08-20 |
2023-08-13 |
rat |
| J J Tong, I M Thompson, X Zhao, P Lacass. Effect of 17β-estradiol on milk production, hormone secretion, and mammary gland gene expression in dairy cows. Journal of dairy science. vol 101. issue 3. 2018-08-10. PMID:29274969. |
the mrna levels of genes encoding proteins related to mammary activity (α-lactalbumin, β-casein, and acetyl-coenzyme a carboxylase), apoptosis (bax, bcl2, and caspase-3), prl receptors (prlr; long and short forms), signal transducer and activator of transcription 5 (stat5a and stat5b), and suppressors of cytokine signaling (socs2 and socs3) were evaluated by real-time reverse transcription pcr using rna extracted from milk fat and mammary biopsies. |
2018-08-10 |
2023-08-13 |
Not clear |
| Yuyu Xu, Lixing Wu, Aochang Chen, Chaoqi Xu, Qing Fen. Protective Effects of Olive Leaf Extract on Acrolein-Exacerbated Myocardial Infarction via an Endoplasmic Reticulum Stress Pathway. International journal of molecular sciences. vol 19. issue 2. 2018-08-10. PMID:29414845. |
the apoptosis marker, bax, was also higher while the anti-apoptosis indicator, bcl2 expression was lower both at protein and mrna levels in the combination group. |
2018-08-10 |
2023-08-13 |
rat |
| Suwei Zhang, Qiaoxin Zhang, Ganggang Shi, Jun Yi. MiR-182-5p regulates BCL2L12 and BCL2 expression in acute myeloid leukemia as a potential therapeutic target. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 97. 2018-08-07. PMID:29136958. |
inhibition of mir-182-5p promoted aml cell apoptosis by targeting bcl2 or bcl2l12. |
2018-08-07 |
2023-08-13 |
Not clear |
| Suwei Zhang, Qiaoxin Zhang, Ganggang Shi, Jun Yi. MiR-182-5p regulates BCL2L12 and BCL2 expression in acute myeloid leukemia as a potential therapeutic target. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 97. 2018-08-07. PMID:29136958. |
the study demonstrates that high levels of mir-182-5p in aml promotes cell proliferation and suppresses cell apoptosis by targeting bcl2l12 and bcl2. |
2018-08-07 |
2023-08-13 |
Not clear |