| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sri Renukadevi Balusamy, Haribalan Perumalsamy, Md Amdad Huq, Balamuralikrishnan Balasubramania. Anti-proliferative activity of Origanum vulgare inhibited lipogenesis and induced mitochondrial mediated apoptosis in human stomach cancer cell lines. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 108. 2019-03-18. PMID:30372889. |
the increase of bax expression and downregulation of bcl2 expression indicated that oregano eo induced mitochondrial mediated apoptosis. |
2019-03-18 |
2023-08-13 |
human |
| Banudevi Sivanantham, UmaMaheswari Krishnan, Vignesh Rajendira. Amelioration of oxidative stress in differentiated neuronal cells by rutin regulated by a concentration switch. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 108. 2019-03-14. PMID:30212708. |
the study showed that the high (100 μm) and low (100 nm and 10μm) rutin concentrations significantly avert ros generation by two different mechanisms, by enhancing apoptosis through the modulation of levels of bcl2, caspase-3, survivin and its antioxidant activity via stress-related proteins, jnk and p38 mapk. |
2019-03-14 |
2023-08-13 |
human |
| Wan Wang, Di Wen, Weisong Duan, Juntao Yin, Can Cui, Ying Wang, Zhongyao Li, Yakun Liu, Chunyan L. Systemic administration of scAAV9-IGF1 extends survival in SOD1 Brain research bulletin. vol 139. 2019-03-12. PMID:29499331. |
furthermore, we detected the levels of proteins involved in the apoptosis pathway and found that the apoptotic inhibitor bcl2 increased and the apoptotic promoter bax, caspase 3, and caspase 9 decreased. |
2019-03-12 |
2023-08-13 |
mouse |
| Bruno Martinucci, Brenda de Carvalho Minatel, Maira Smaniotto Cucielo, Mariana Medeiros, Ivan José Vechetti-Junior, Sérgio Luis Felisbino, Flávia Karina Delell. Basement membrane extract attenuates the more malignant gene expression profile accentuated by fibronectin in prostate cancer cells. Molecular and cellular biochemistry. vol 451. issue 1-2. 2019-03-08. PMID:29961211. |
when fn was the predominant matrix element, such as in blood plasma, pca tumor cells increased their expression of genes related to an invasive behavior and resistance to apoptosis, including cdh2, itga5, akt1, and bcl2. |
2019-03-08 |
2023-08-13 |
Not clear |
| Dan Li, Gangcheng Wang, Guoguo Jin, Ke Yao, Zhenjiang Zhao, Liangyu Bie, Yongjun Guo, Ning Li, Wenying Deng, Xiaobin Chen, Beibei Chen, Yuanyuan Liu, Suxia Luo, Zhiping Gu. Resveratrol suppresses colon cancer growth by targeting the AKT/STAT3 signaling pathway. International journal of molecular medicine. vol 43. issue 1. 2019-03-05. PMID:30387805. |
additionally, resveratrol treatment decreased the protein expression levels of cyclin d1, cyclin e2 and bcl2 apoptosis regulator, while it increased bcl2 associated x and tumor protein p53, all of which are involved in the regulation of cell cycle and apoptosis. |
2019-03-05 |
2023-08-13 |
Not clear |
| Riccardo Moia, Fary Diop, Chiara Favini, Ahad Ahmed Kodipad, Gianluca Gaidan. Potential of BCL2 as a target for chronic lymphocytic leukemia treatment. Expert review of hematology. vol 11. issue 5. 2019-02-28. PMID:29561706. |
areas covered: this article covers the biology of apoptosis in cll from a translational viewpoint and deals with the mode of action of bcl2 inhibitors, in particular venetoclax. |
2019-02-28 |
2023-08-13 |
Not clear |
| Emanuel Candeias, Inês Sebastião, Susana Cardoso, Cristina Carvalho, Maria Sancha Santos, Catarina Resende Oliveira, Paula I Moreira, Ana I Duart. Brain GLP-1/IGF-1 Signaling and Autophagy Mediate Exendin-4 Protection Against Apoptosis in Type 2 Diabetic Rats. Molecular neurobiology. vol 55. issue 5. 2019-02-26. PMID:28573460. |
moreover, ex-4 regulated several markers for autophagy in gk rat brains (as mtor, pi3k class iii, lc3 ii, atg7, p62, lamp-1, and parkin), ultimately protecting against apoptosis (by decreasing several caspase-like activities and mitochondrial cytochrome c, and increasing bcl2 levels upon t2d). |
2019-02-26 |
2023-08-13 |
rat |
| Hector Mesa, Wendy Larson, Juan C Manive. Acquired adenomatous hyperplasia of the rete testis: an immunohistochemical study of its pathogenesis. Human pathology. vol 73. 2019-02-13. PMID:28970137. |
we performed immunohistochemical studies using markers of cell cycle (cyclin d1, p16), proliferation (ki-67), apoptosis (bcl2), senescence (γ-h2ax), and androgen receptors to try to provide scientific support for or refute existing hypotheses. |
2019-02-13 |
2023-08-13 |
Not clear |
| Yuanzhi Zhao, Cong Zhou, Hang Yu, Wenwu Zhang, Fang Cheng, Haihang Yu, Dongsheng Zhou, Bin Li, Jing Liu, Jie Dai, Jie Zhong, Min Chen, Tianyi Huang, Ranran Pan, Shiwei Duan, Zhenyu H. Association between the methylation of six apoptosis‑associated genes with autism spectrum disorder. Molecular medicine reports. vol 18. issue 5. 2019-02-12. PMID:30221723. |
the aim of the present study was to investigate the association between the methylation of six apoptosis‑associated genes [transforming growth factor β 1 (tgfb1), bcl2 associated x, apoptosis regulator, insulin like growth factor binding protein 3, protein kinase c β 1, presenilin 2 and c‑c motif chemokine ligand 2] and asd. |
2019-02-12 |
2023-08-13 |
human |
| R S Redman, E Paal, S Chauhan, R Avers, N Bayle. Botryoid odontogenic cyst. Exploration of proliferative activity, apoptosis and expression of TP53 and BCL2 compared to the histologically identical lateral periodontal and gingival cysts. Biotechnic & histochemistry : official publication of the Biological Stain Commission. vol 92. issue 8. 2019-02-08. PMID:28910164. |
exploration of proliferative activity, apoptosis and expression of tp53 and bcl2 compared to the histologically identical lateral periodontal and gingival cysts. |
2019-02-08 |
2023-08-13 |
Not clear |
| R S Redman, E Paal, S Chauhan, R Avers, N Bayle. Botryoid odontogenic cyst. Exploration of proliferative activity, apoptosis and expression of TP53 and BCL2 compared to the histologically identical lateral periodontal and gingival cysts. Biotechnic & histochemistry : official publication of the Biological Stain Commission. vol 92. issue 8. 2019-02-08. PMID:28910164. |
sections of neutral buffered formalin fixed, paraffin-embedded tissues from the boc and archival specimens of four gcs, four lpcs and three odontogenic keratocysts (okcs) were stained using immunohistochemistry for ki-67, a marker of proliferating cells, caspase-3, a marker of cells undergoing apoptosis, tumor suppressor p53, and the apoptosis inhibitor bcl2. |
2019-02-08 |
2023-08-13 |
Not clear |
| Ashutosh Ranjan, Mayank Choubey, Toshihiko Yada, Amitabh Krishn. Direct effects of neuropeptide nesfatin-1 on testicular spermatogenesis and steroidogenesis of the adult mice. General and comparative endocrinology. vol 271. 2019-02-04. PMID:30391240. |
furthermore, the in vitro treatment with nesfatin-1 showed stimulatory effects on spermatogenesis by promoting cell proliferation (pcna) and survival (bcl2), while inhibiting apoptosis (caspase-3) in the testes. |
2019-02-04 |
2023-08-13 |
mouse |
| Fábio Henrique Fernandes, Mrio Otvio Botasso-Nasciutti, Andr Luiz Ventura Svio, Leonardo da Cunha Menezes Souza, Jhennifer Rebecca Fernandes-Cal, Fbio Florena Cardoso, Marcos Roberto de Mattos Fontes, Anjana Fernandes Albuquerque, Carla C Munari, Fbio Kummrow, Gisela de Aragão Umbuzeiro, Daisy Maria Fvero Salvador. In Vivo genotoxicity of a commercial C.I. Disperse Red 1 dye. Environmental and molecular mutagenesis. vol 59. issue 9. 2019-01-31. PMID:30152043. |
additionally, upregulation of genes involved in the inflammatory process (il1b) (0.0005 and 0.005 mg/kg bw) and cell-cycle control (cdkn1a) in liver cells, and apoptosis (bcl2 and bax) in leukocytes (0.005 mg/kg bw) were also detected. |
2019-01-31 |
2023-08-13 |
mouse |
| Ran Wu, Hui Yang, Jiangbo Wan, Xiaohui Deng, Linjun Chen, Siguo Hao, Liyuan M. Knockdown of the Hippo transducer YAP reduces proliferation and promotes apoptosis in the Jurkat leukemia cell. Molecular medicine reports. vol 18. issue 6. 2019-01-28. PMID:30320399. |
it was also demonstrated that yap knockdown resulted in deregulated expression of a cluster of downstream genes crucial to cell proliferation or apoptosis, including protein kinase b, b‑cell lymphoma 2 (bcl2) and bcl2 like protein 1. |
2019-01-28 |
2023-08-13 |
Not clear |
| Jun Yong, Li Yan, Jing Wang, Hongmei Xiao, Qingfan Zen. Effects of compound 21, a non‑peptide angiotensin II type 2 receptor agonist, on general anesthesia‑induced cerebral injury in neonatal rats. Molecular medicine reports. vol 18. issue 6. 2019-01-28. PMID:30365086. |
bcl2, apoptosis regulator (bcl‑2) expression was also measured. |
2019-01-28 |
2023-08-13 |
rat |
| Xiaotong Wang, Xiaopeng Cui, Chuanwu Zhu, Ming Li, Juan Zhao, Zhongyi Shen, Xiaohang Shan, Liang Wang, Han Wu, Yanting Shen, You Ni, Dongmei Zhang, Guoxiong Zho. FKBP11 protects intestinal epithelial cells against inflammation‑induced apoptosis via the JNK‑caspase pathway in Crohn's disease. Molecular medicine reports. vol 18. issue 5. 2019-01-25. PMID:30221722. |
overexpression of fkbp11 was revealed to significantly attenuate the elevated expression of pro‑apoptotic proteins (bcl2 associated x apoptosis regulator, caspase‑12 and active caspase‑3), suppress the phosphorylation of c‑jun n‑terminal kinase (jnk), and decrease apoptosis of ifn‑γ/tnf‑α stimulated iecs. |
2019-01-25 |
2023-08-13 |
mouse |
| James C Romero-Masters, Makoto Ohashi, Reza Djavadian, Mark R Eichelberg, Mitch Hayes, Jillian A Bristol, Shidong Ma, Erik A Ranheim, Jenny Gumperz, Eric C Johannsen, Shannon C Kenne. An EBNA3C-deleted Epstein-Barr virus (EBV) mutant causes B-cell lymphomas with delayed onset in a cord blood-humanized mouse model. PLoS pathogens. vol 14. issue 8. 2019-01-22. PMID:30125329. |
the anti-apoptotic proteins, bcl2 and irf4, were expressed in Δ3c-infected tumors, likely helping cells avoid c-myc-induced apoptosis. |
2019-01-22 |
2023-08-13 |
mouse |
| Tatsuya Suzuki, Toru Okamoto, Hiroshi Katoh, Yukari Sugiyama, Shinji Kusakabe, Makoto Tokunaga, Junki Hirano, Yuka Miyata, Takasuke Fukuhara, Masahito Ikawa, Takashi Satoh, Sachiyo Yoshio, Ryosuke Suzuki, Masayuki Saijo, David C S Huang, Tatsuya Kanto, Shizuo Akira, Yoshiharu Matsuur. Infection with flaviviruses requires BCLXL for cell survival. PLoS pathogens. vol 14. issue 9. 2019-01-22. PMID:30261081. |
bcl2 family proteins including pro-survival proteins, bh3-only proteins and bax/bak proteins control mitochondria-mediated apoptosis to maintain cell homeostasis via the removal of damaged cells and pathogen-infected cells. |
2019-01-22 |
2023-08-13 |
Not clear |
| Tatsuya Suzuki, Toru Okamoto, Hiroshi Katoh, Yukari Sugiyama, Shinji Kusakabe, Makoto Tokunaga, Junki Hirano, Yuka Miyata, Takasuke Fukuhara, Masahito Ikawa, Takashi Satoh, Sachiyo Yoshio, Ryosuke Suzuki, Masayuki Saijo, David C S Huang, Tatsuya Kanto, Shizuo Akira, Yoshiharu Matsuur. Infection with flaviviruses requires BCLXL for cell survival. PLoS pathogens. vol 14. issue 9. 2019-01-22. PMID:30261081. |
in this study, we examined the roles of bcl2 proteins in the induction of apoptosis in cells upon infection with flaviviruses, such as japanese encephalitis virus, dengue virus and zika virus. |
2019-01-22 |
2023-08-13 |
Not clear |
| Yu-Zhong Yang, Yun-Feng Zhang, Lei Yang, Jing Xu, Xu-Ming Mo, Wei Pen. miR‑760 mediates hypoxia-induced proliferation and apoptosis of human pulmonary artery smooth muscle cells via targeting TLR4. International journal of molecular medicine. vol 42. issue 5. 2019-01-21. PMID:30226538. |
expression of exogenous mir‑760 decreased cell proliferation in hypoxia‑induced hpasmcs, and promoted cell apoptosis with an increase in the bcl2 associated x/bcl2 ratio and the expression levels of caspase‑3 and caspase‑9. |
2019-01-21 |
2023-08-13 |
human |