| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ying Wu, Zhe Wang, Jing Kong, Jian Zhang, Rui Lin. [Aspirin inhibits the proliferation of breast cancer cells via inducing apoptosis and autophagy]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 33. issue 10. 2018-05-15. PMID:29169419. |
methods mtt assay was performed to detect the effect of aspirin on cell proliferation of cancer cells; flow cytometry was performed to assess the effect of aspirin on cell apoptosis; western blotting was used to determine the protein expressions of apoptosis-related proteins bcl2, cleaved caspase-3 (c-caspase-3), cleaved parp (c-parp) and autophagy-related gene 3 (atg3), lc3a, lc3b. |
2018-05-15 |
2023-08-13 |
human |
| Naimisha Beeravolu, Christina McKee, G Rasul Chaudhr. Mechanism of arsenite toxicity in embryonic stem cells. Journal of applied toxicology : JAT. vol 37. issue 10. 2018-05-10. PMID:28370166. |
although ias caused slight apoptosis with a concomitant increase in ros levels, the exposed escs had significant bcl2 expression, which could be involved in the protection against apoptosis. |
2018-05-10 |
2023-08-13 |
mouse |
| Hong-Yan Lu, Xiao-Qing Chen, Wei Tang, Qiu-Xia Wang, Jie Zhan. GRP78 silencing enhances hyperoxia-induced alveolar epithelial cell apoptosis via CHOP pathway. Molecular medicine reports. vol 16. issue 2. 2018-05-10. PMID:28586043. |
the overexpression of chop downregulated b‑cell lymphoma (bcl)‑2 expression levels, upregulated bcl2 associated x (bax), and increased apoptosis of a549 cells under conditions of hyperoxia. |
2018-05-10 |
2023-08-13 |
human |
| Satoko Arakawa, Masatsune Tsujioka, Tatsushi Yoshida, Hajime Tajima-Sakurai, Yuya Nishida, Yosuke Matsuoka, Ikuyo Yoshino, Yoshihide Tsujimoto, Shigeomi Shimiz. Role of Atg5-dependent cell death in the embryonic development of Bax/Bak double-knockout mice. Cell death and differentiation. vol 24. issue 9. 2018-05-07. PMID:28574506. |
members of the bcl2 family regulate apoptosis, among which bax and bak act as a mitochondrial gateway. |
2018-05-07 |
2023-08-13 |
mouse |
| Andrew W Roberts, Stephan Stilgenbauer, John F Seymour, David C S Huan. Venetoclax in Patients with Previously Treated Chronic Lymphocytic Leukemia. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 23. issue 16. 2018-04-30. PMID:28100580. |
acting as a pharmacologic mimic of the proteins that initiate apoptosis (a so-called bh3 mimetic), venetoclax rapidly induces apoptosis in chronic lymphocytic leukemia (cll) cells, which express high levels of bcl2 and rely on it to maintain their survival. |
2018-04-30 |
2023-08-13 |
Not clear |
| Kai-Hong Zhao, Can Zhang, Yue Bai, Yan Li, Xun Kang, Jian-Xin Chen, Kun Yao, Tao Jiang, Xiao-Song Zhong, Wen-Bin L. Antiglioma effects of cytarabine on leptomeningeal metastasis of high-grade glioma by targeting the PI3K/Akt/mTOR pathway. Drug design, development and therapy. vol 11. 2018-04-26. PMID:28721010. |
the present study confirmed that cytarabine inhibits proliferation and promotes apoptosis of u87 cells, and molecular analysis of this effect showed that cytarabine significantly reduces expression of phosphatidylinositol 3-kinase/serine/threonine kinase also known as the protein kinase b/mechanistic target of rapamycin (pi3k/akt/mtor) pathway, ki-67, bcl2, and 4-1bb, and upregulates bax and cleaved caspase-3. |
2018-04-26 |
2023-08-13 |
human |
| Luo-Cheng Li, Zhi-Wei Wang, Xiao-Ping Hu, Zhi-Yong Wu, Zhi-Peng Hu, Yong-Le Rua. MDG‑1 inhibits H2O2‑induced apoptosis and inflammation in human umbilical vein endothelial cells. Molecular medicine reports. vol 16. issue 3. 2018-04-24. PMID:28713956. |
in addition, pretreatment with mdg‑1 decreased the expression levels of proapoptotic proteins bcl2 associated x (bax) and caspase‑3, while it increased the expression levels of the antiapoptotic protein bcl2 apoptosis regulator (bcl‑2), compared with h2o2 treatment alone. |
2018-04-24 |
2023-08-13 |
human |
| Zhi Cheng, Zhanqiang Du, Yingchun Shang, Yuling Zhang, Tao Zhan. A Preliminary Study: PS1 Increases U1 snRNA Expression Associated with AD. Journal of molecular neuroscience : MN. vol 62. issue 3-4. 2018-04-23. PMID:28577205. |
importantly, the increased levels of bax, bcl2, and bax/bcl2 ratio showed that the overexpression of u1 snrna could cause cell apoptosis. |
2018-04-23 |
2023-08-13 |
Not clear |
| Wan Liang, Likai Ji, Yu Zhang, Yueran Zhen, Qingde Zhang, Xuewen Xu, Bang Li. Transcriptome Differences in Porcine Alveolar Macrophages from Tongcheng and Large White Pigs in Response to Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Infection. International journal of molecular sciences. vol 18. issue 7. 2018-04-17. PMID:28704922. |
for tc pig, 549 specific degs were identified, including vav2, bcl2 and bax, which were enriched in activation of leukocyte extravasation and suppression of apoptosis. |
2018-04-17 |
2023-08-13 |
Not clear |
| Eleonora Ottina, Victor Peperzak, Katia Schoeler, Emma Carrington, Roswitha Sgonc, Marc Pellegrini, Simon Preston, Marco J Herold, Andreas Strasser, Andreas Villunge. DNA-binding of the Tet-transactivator curtails antigen-induced lymphocyte activation in mice. Nature communications. vol 8. issue 1. 2018-04-12. PMID:29044097. |
transactivator-mediated cytotoxicity depends on dna binding, but can be overcome by bcl2 overexpression, suggesting that apoptosis induction upon lymphocyte activation limits cellular and humoral immune responses. |
2018-04-12 |
2023-08-13 |
mouse |
| Arianna Bottoni, George A Cali. MicroRNAs as main players in the pathogenesis of chronic lymphocytic leukemia. MicroRNA (Shariqah, United Arab Emirates). vol 2. issue 3. 2018-04-11. PMID:25069439. |
micrornas (mirnas) are small noncoding rnas able to regulate the expression of many target genes, including the main apoptosis regulators bcl2 and mcl1. |
2018-04-11 |
2023-08-13 |
Not clear |
| Thoria I K Donia, Maria N Gerges, Tarek M Mohame. Amelioration effect of Egyptian sweet orange hesperidin on Ehrlich ascites carcinoma (EAC) bearing mice. Chemico-biological interactions. vol 285. 2018-04-10. PMID:29481770. |
moreover, hesperidin induced apoptosis of tumor cells which appeared as dna fragmentation by down-regulation of bcl2 as anti-apoptotic gene and stimulation of caspase3 and bax genes expression as apoptotic genes. |
2018-04-10 |
2023-08-13 |
mouse |
| Huiying Zhao, Qingchun Liu, Saisai Wang, Fang Dai, Xiaofei Cheng, Xiaobin Cheng, Wenbin Chen, Min Zhang, Dong Che. In vitro additive antitumor effects of dimethoxycurcumin and 5-fluorouracil in colon cancer cells. Cancer medicine. vol 6. issue 7. 2018-03-29. PMID:28573788. |
the induction of apoptosis is involved in the increasing of bax and cytochrome c and decreasing of bcl2 expressions. |
2018-03-29 |
2023-08-13 |
Not clear |
| Y Huang, S-H Liang, L-B Xiang, X-T Han, W Zhang, J Tang, X-H Wu, M-Q Zhan. [miR-218 Promoted the Apoptosis of Human Ovarian Carcinoma Cells via Suppression of the WNT/β-Catenin Signaling Pathway]. Molekuliarnaia biologiia. vol 51. issue 4. 2018-03-23. PMID:28900081. |
after over-expressing mir-218 in human ovarian carcinoma (ovcar3) cells, cell viability was determined by mtt method, cell apoptosis was observed by flow cytometry (fcm), mrna expression of mir-218, bcl2, bax was measured by rt-pcr and protein expression levels of wnt, tankyrase and β-catenin were quantified by western blots. |
2018-03-23 |
2023-08-13 |
human |
| X Qian, C Tan, B Yang, F Wang, Y Ge, Z Guan, J Ca. Astaxanthin increases radiosensitivity in esophageal squamous cell carcinoma through inducing apoptosis and G2/M arrest. Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus. vol 30. issue 6. 2018-03-14. PMID:28475750. |
it was shown that atx improved radiosensitivity of escc cells and induced apoptosis and g2/m arrest via inhibiting bcl2, cyclinb1, cdc2, and promoting bax expression. |
2018-03-14 |
2023-08-13 |
Not clear |
| Erica Anspach Will, Xiufang Liu, John J Pelus. AG 205, a progesterone receptor membrane component 1 antagonist, ablates progesterone's ability to block oxidative stress-induced apoptosis of human granulosa/luteal cells†. Biology of reproduction. vol 96. issue 4. 2018-03-12. PMID:28371915. |
harakiri is a bh-3 only member of the b-cell lymphoma 2 (bcl2) family that promotes apoptosis by binding to and antagonizing the antiapoptotic action of bcl2- and bcl2-like proteins. |
2018-03-12 |
2023-08-13 |
human |
| Patricia G Tremblay, Marc-André Sirar. Transcriptomic analysis of gene cascades involved in protein kinase A and C signaling in the KGN line of human ovarian granulosa tumor cells†. Biology of reproduction. vol 96. issue 4. 2018-03-12. PMID:28383663. |
gene associations with seven major ovarian functions were identified: prostaglandin- endoperoxide synthase 2 (ptgs2), interleukin 8 (il8), and interleukin 6 (il6) with inflammation; steroidogenic acute regulatory protein (star), cytochrome p450scc (cyp11a1), and cytochrome p450 family 19 subfamily a member 1 (cyp19a1) with steroidogenesis; vascular endothelial growth factor c (vegfc), vascular endothelial growth factor a (vegfa), and c-x-c chemokine receptor type 4 (cxcr4) with angiogenesis; amphiregulin (areg), epidermal growth factor receptor (egfr), and sprouty rtk signaling antagonist 2 (spry2) with differentiation, bcl2 associated x (bax), bcl2 like 12 (bcl2l12), and caspase 1(casp1) with apoptosis, cyclin d1 (ccnd1), cyclin b1 (ccnb1), and cyclin b2 (ccnb2) with division; and matrix metalloproteinase-1 (mmp1), matrix metallopeptidase 9 (mmp9), and timp metallopeptidase inhibitor 1 (timp1) with ovulation. |
2018-03-12 |
2023-08-13 |
human |
| Md Mostafizur Rahman, Rachael A Uson-Lopez, Md Tajuddin Sikder, Gongxun Tan, Toshiyuki Hosokawa, Takeshi Saito, Masaaki Kurasak. Ameliorative effects of selenium on arsenic-induced cytotoxicity in PC12 cells via modulating autophagy/apoptosis. Chemosphere. vol 196. 2018-03-12. PMID:29324385. |
furthermore, western blot analyses revealed that simultaneous exposure of both metals significantly inhibited autophagy which further suppressed apoptosis through positively regulation of key proteins; p-mtor, p-akt, p-foxo1a, p62, and expression of ubiquitin, bax, bcl2, nfкb, and caspases 3 and 9, although those are negatively regulated by arsenic. |
2018-03-12 |
2023-08-13 |
human |
| Yuan-Chin Lee, Ying-Jung Chen, Chia-Hui Huang, Long-Sen Chan. Amsacrine-induced apoptosis of human leukemia U937 cells is mediated by the inhibition of AKT- and ERK-induced stabilization of MCL1. Apoptosis : an international journal on programmed cell death. vol 22. issue 3. 2018-03-06. PMID:27757735. |
however, 9-aminoacridine derivatives, which have the same structural scaffold as amsacrine, induce cancer cell apoptosis by altering the expression of bcl2 family proteins. |
2018-03-06 |
2023-08-13 |
human |
| Jing Sun, Xin Zhang, Yang Sun, Zhi-Shu Tang, Dong-Yan Gu. Effects of Hylomecon vernalis ethanol extracts on cell cycle and apoptosis of colon cancer cells. Molecular medicine reports. vol 15. issue 6. 2018-03-05. PMID:28393197. |
in addition, hvmee induced apoptosis in ht‑29 and sw620 cells, by increasing caspase‑3, caspase‑9 and bcl2 associated x expression, and reducing bcl‑2 expression. |
2018-03-05 |
2023-08-13 |
human |