| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yan Li, Haixu Wang, Dangxia Zhou, Ting Shuang, Haibo Zhao, Biliang Che. Up-Regulation of Long Noncoding RNA SRA Promotes Cell Growth, Inhibits Cell Apoptosis, and Induces Secretion of Estradiol and Progesterone in Ovarian Granular Cells of Mice. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2018-09-18. PMID:29674607. |
results we demonstrated that elevated lncrna sra stimulated cell growth, changed distribution of cell cycle phases with increase of cyclin b, cyclin e, and cyclin d1, and inhibited cell apoptosis with up-regulation of bcl2 and down-regulation of bax, cleaved-caspase 3, and cleaved-parp. |
2018-09-18 |
2023-08-13 |
mouse |
| Subhadip Hajra, Arup Ranjan Patra, Abhishek Basu, Sudin Bhattachary. Prevention of doxorubicin (DOX)-induced genotoxicity and cardiotoxicity: Effect of plant derived small molecule indole-3-carbinol (I3C) on oxidative stress and inflammation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 101. 2018-09-13. PMID:29494960. |
moreover, i3c attenuate dox-induced apoptosis by up-regulation of bcl2 and down-regulation of bax and caspase-3 expression in bone marrow cells. |
2018-09-13 |
2023-08-13 |
mouse |
| Yahima Frión-Herrera, Alexis Díaz-García, Jenny Ruiz-Fuentes, Hermis Rodríguez-Sánchez, José Maurício Sforci. Mechanisms underlying the cytotoxic effect of propolis on human laryngeal epidermoid carcinoma cells. Natural product research. vol 32. issue 17. 2018-09-11. PMID:28783983. |
both samples induced apoptosis via activation of tp53, casp3, bax, p21 signalling, and downregulation of bcl2 and bcl-xl. |
2018-09-11 |
2023-08-13 |
human |
| Bahadir Batar, Tuba Mutlu, Merve Bostanci, Mustafa Akin, Matem Tuncdemir, Nuran Bese, Mehmet Guve. DNA repair and apoptosis: Roles in radiotherapy-related acute reactions in breast cancer patients. Cellular and molecular biology (Noisy-le-Grand, France). vol 64. issue 4. 2018-09-11. PMID:29631685. |
our aim was to define the association of dna repair (ercc1 and xpc) and apoptotic (bcl2, casp3 and nfkb1) gene expression, dna damage levels, apoptosis changes and dna repair gene variations with the risk of acute side effects in breast cancer patients. |
2018-09-11 |
2023-08-13 |
Not clear |
| Jie Yuan, Xueyan Zhao, Yujuan Hu, Haiying Sun, Guoqing Gong, Xiang Huang, Xubo Chen, Mingyu Xia, Chen Sun, Qilin Huang, Yu Sun, Wen Kong, Weijia Kon. Autophagy regulates the degeneration of the auditory cortex through the AMPK-mTOR-ULK1 signaling pathway. International journal of molecular medicine. vol 41. issue 4. 2018-08-29. PMID:29344647. |
however, lc3, becn1, bcl2 and bcl‑xl were decreased at 15 months in the d-gal group, with cell apoptosis significantly increased and substantial neuron degeneration. |
2018-08-29 |
2023-08-13 |
rat |
| Antonio Piras, Lorenzo Schiaffino, Marina Boido, Valeria Valsecchi, Michela Guglielmotto, Elena De Amicis, Julien Puyal, Ana Garcera, Elena Tamagno, Rosa M Soler, Alessandro Vercell. Inhibition of autophagy delays motoneuron degeneration and extends lifespan in a mouse model of spinal muscular atrophy. Cell death & disease. vol 8. issue 12. 2018-08-27. PMID:29259166. |
inhibition of autophagy by 3-ma suppressed autophagosome formation, reduced the apoptotic activation (cleaved caspase-3 and bcl2) and the appearance of terminal deoxynucleotidyl transferase dutp nick end labeling (tunel)-positive neurons, underlining that apoptosis and autophagy pathways are intricately intertwined. |
2018-08-27 |
2023-08-13 |
mouse |
| Hui-Zhen Zheng, Xue-Kun Fu, Jiu-Long Shang, Rong-Xi Lu, Yong-Fang Ou, Chun-Ling Che. Ginsenoside Rg1 protects rat bone marrow mesenchymal stem cells against ischemia induced apoptosis through miR-494-3p and ROCK-1. European journal of pharmacology. vol 822. 2018-08-20. PMID:29307726. |
rbmscs treated with hypoxia and serum deprivation for 24h (h/sd-rbmscs) showed the up-regulated expression of ras homolog family member a (rhoa), rho associated coiled-coil containing protein kinase 1 (rock-1), myosin light chain 2 (mlc-2), bcl2 associated agonist of cell death (bad) and bcl2 associated x, apoptosis regulator (bax); while the expression of mir-148b-3p, mir-148b-5p and mir-494-3p was down-regulated. |
2018-08-20 |
2023-08-13 |
rat |
| J J Tong, I M Thompson, X Zhao, P Lacass. Effect of 17β-estradiol on milk production, hormone secretion, and mammary gland gene expression in dairy cows. Journal of dairy science. vol 101. issue 3. 2018-08-10. PMID:29274969. |
the mrna levels of genes encoding proteins related to mammary activity (α-lactalbumin, β-casein, and acetyl-coenzyme a carboxylase), apoptosis (bax, bcl2, and caspase-3), prl receptors (prlr; long and short forms), signal transducer and activator of transcription 5 (stat5a and stat5b), and suppressors of cytokine signaling (socs2 and socs3) were evaluated by real-time reverse transcription pcr using rna extracted from milk fat and mammary biopsies. |
2018-08-10 |
2023-08-13 |
Not clear |
| Yuyu Xu, Lixing Wu, Aochang Chen, Chaoqi Xu, Qing Fen. Protective Effects of Olive Leaf Extract on Acrolein-Exacerbated Myocardial Infarction via an Endoplasmic Reticulum Stress Pathway. International journal of molecular sciences. vol 19. issue 2. 2018-08-10. PMID:29414845. |
the apoptosis marker, bax, was also higher while the anti-apoptosis indicator, bcl2 expression was lower both at protein and mrna levels in the combination group. |
2018-08-10 |
2023-08-13 |
rat |
| Suwei Zhang, Qiaoxin Zhang, Ganggang Shi, Jun Yi. MiR-182-5p regulates BCL2L12 and BCL2 expression in acute myeloid leukemia as a potential therapeutic target. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 97. 2018-08-07. PMID:29136958. |
inhibition of mir-182-5p promoted aml cell apoptosis by targeting bcl2 or bcl2l12. |
2018-08-07 |
2023-08-13 |
Not clear |
| Suwei Zhang, Qiaoxin Zhang, Ganggang Shi, Jun Yi. MiR-182-5p regulates BCL2L12 and BCL2 expression in acute myeloid leukemia as a potential therapeutic target. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 97. 2018-08-07. PMID:29136958. |
the study demonstrates that high levels of mir-182-5p in aml promotes cell proliferation and suppresses cell apoptosis by targeting bcl2l12 and bcl2. |
2018-08-07 |
2023-08-13 |
Not clear |
| Tongwang Yang, Tao Wu, Liping Lv, Zhiqiang Zhang, Dongjie Liu, Jianji Xu, Dexi Chen, Gang W. Ceria Oxide Nanoparticles an Ideal Carrier Given Little Stress to Cells and Rats. Journal of nanoscience and nanotechnology. vol 18. issue 6. 2018-08-06. PMID:29442720. |
luckily, compare with silicon oxide nanoparticles and zinc oxide nanoparticles, autophagy and late apoptosis were failed to fund in ceria oxide nanoparticles groups in 100 μg/ml in cell lines for 12 h. at the same time, the autophagy related genes lc3, atg5, beclin1 and bcl2 were not change in protein level at 0 to 200 μg/ml. |
2018-08-06 |
2023-08-13 |
rat |
| Jia Cui, William J Placze. Post-Transcriptional Regulation of Anti-Apoptotic BCL2 Family Members. International journal of molecular sciences. vol 19. issue 1. 2018-08-03. PMID:29361709. |
anti-apoptotic b cell lymphoma 2 (bcl2) family members (bcl2, mcl1, bclxl, bclw, and bfl1) are key players in the regulation of intrinsic apoptosis. |
2018-08-03 |
2023-08-13 |
Not clear |
| Jia Cui, William J Placze. Post-Transcriptional Regulation of Anti-Apoptotic BCL2 Family Members. International journal of molecular sciences. vol 19. issue 1. 2018-08-03. PMID:29361709. |
we also point out the importance of future studies in characterizing the crosstalk between rbps and mirnas in regulating anti-apoptotic bcl2 family member expression and ultimately apoptosis. |
2018-08-03 |
2023-08-13 |
Not clear |
| Florian Simon, Alexander Oberhuber, Nikolaos Floros, Albert Busch, Markus Udo Wagenhäuser, Hubert Schelzig, Mansur Dura. Acute Limb Ischemia-Much More Than Just a Lack of Oxygen. International journal of molecular sciences. vol 19. issue 2. 2018-08-01. PMID:29373539. |
due to the lack of atp, individual cell organelles can no longer sustain their activity, thus initiating the cascade pathways of apoptosis via the release of cytokines such as the bcl2 associated x protein (bax). |
2018-08-01 |
2023-08-13 |
Not clear |
| Thi-Anh Pham, Imran Shair Mohammad, Van-Tuan Vu, Xiao-Long Hu, Chaurasiya Birendra, Aftab Ulah, Cui Guo, Xian-Yu Lü, Wen-Cai Ye, Hao Wan. Phloroglucinol Derivatives from the Fruits of Eucalyptus globulus and Their Cytotoxic Activities. Chemistry & biodiversity. vol 15. issue 6. 2018-07-30. PMID:29692000. |
additionally, after treatment with eucalyptin b (1), the apoptosis factor proteins (bcl2 and bax) and caspase-3 levels in a549 cells were also determined by western-blot analysis. |
2018-07-30 |
2023-08-13 |
Not clear |
| Bruna Cristine de Almeida, Natalia Garcia, Giovana Maffazioli, Laura Gonzalez dos Anjos, Edmund Chada Baracat, Katia Candido Carvalh. Oncomirs Expression Profiling in Uterine Leiomyosarcoma Cells. International journal of molecular sciences. vol 19. issue 1. 2018-07-27. PMID:29295562. |
we identified four differentially expressed mirnas with the same profile when compared with patients' samples, which strongly interacted with relevant genes, including apoptosis regulator (bcl2), epidermal growth factor receptor (egfr), vascular endothelial growth factor a (vegfa), insulin like growth factor 1 receptor (igf1r),serine/threonine kinase (raf1), receptor tyrosine kinase (met), and bhlh transcription factor (mycn). |
2018-07-27 |
2023-08-13 |
Not clear |
| Shanshan Cui, Wen Li, Pengyan Wang, Xin Lv, Yuxia Gao, Guowei Huan. Folic acid inhibits homocysteine-induced cell apoptosis in human umbilical vein endothelial cells. Molecular and cellular biochemistry. vol 444. issue 1-2. 2018-07-25. PMID:29250709. |
to further investigate how folic acid influenced cell apoptosis, we also analyzed the activities of caspase-3/7 and the mrna and protein expressions of bcl2, bax, tp53, casp3, and casp8 in human umbilical vein endothelial cells. |
2018-07-25 |
2023-08-13 |
human |
| Mohamed A Lebda, Kadry M Sadek, Yasser S El-Saye. Aspartame and Soft Drink-Mediated Neurotoxicity in Rats: Implication of Oxidative Stress, Apoptotic Signaling Pathways, Electrolytes and Hormonal Levels. Metabolic brain disease. vol 32. issue 5. 2018-07-23. PMID:28660358. |
brain mrna transcripts of target genes showed that aspartame and soft drink induced upregulation of bax, casp3, p27 and mdm2 (1.5-fold) and down-regulation of bcl2, suggesting an activation of cellular apoptosis. |
2018-07-23 |
2023-08-13 |
rat |
| E Matías Belotti, Antonela F Stassi, Melisa M L Velázquez, Pablo U Díaz, Belkis E Marelli, Florencia Rey, Ulises S Notaro, Hugo H Ortega, Natalia R Salvett. Changes in the Proliferation/Apoptosis Balance in the Bovine Ovary: A Key Early Event in Follicular Persistence. Cells, tissues, organs. vol 204. issue 5-6. 2018-07-23. PMID:29130964. |
we analyzed cell proliferation by evaluating the expression of ki-67 and apoptosis by evaluating caspase-3, bax, and bcl2 expression. |
2018-07-23 |
2023-08-13 |
cattle |