| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yanping Feng, Fang Liu, Zhixiang Du, Dongjie Zhao, Jianxin Cheng, Wei Gu. Wip1 regulates SKOV3 cell apoptosis through the p38 MAPK signaling pathway. Molecular medicine reports. vol 15. issue 6. 2018-03-05. PMID:28440479. |
western blot analysis was performed to determine expression of tumor protein 53 (p53), cleaved caspase‑3, caspase‑3, bcl2 associated x (bax), bcl2 apoptosis regulator (bcl‑2), p38 mitogen‑activated protein kinase (p38 mapk) and phosphorylated (p)‑p38 mapk. |
2018-03-05 |
2023-08-13 |
human |
| Emily K Sims, Alexander J Lakhter, Emily Anderson-Baucum, Tatsuyoshi Kono, Xin Tong, Carmella Evans-Molin. MicroRNA 21 targets BCL2 mRNA to increase apoptosis in rat and human beta cells. Diabetologia. vol 60. issue 6. 2018-02-28. PMID:28280903. |
microrna 21 targets bcl2 mrna to increase apoptosis in rat and human beta cells. |
2018-02-28 |
2023-08-13 |
human |
| V I Loginov, I V Pronina, A M Burdennyi, E A Pereyaslova, E A Braga, T P Kazubskaya, N E Kushlinski. Role of Methylation in the Regulation of Apoptosis Genes APAF1, DAPK1, and BCL2 in Breast Cancer. Bulletin of experimental biology and medicine. vol 162. issue 6. 2018-02-23. PMID:28429233. |
role of methylation in the regulation of apoptosis genes apaf1, dapk1, and bcl2 in breast cancer. |
2018-02-23 |
2023-08-13 |
Not clear |
| Quan Zhou, Fengli Chen, Jiali Zhao, Baojun Li, Yong Liang, Wei Pan, Shaoxian Zhang, Xinhong Wang, Donghui Zhen. Long non-coding RNA PVT1 promotes osteosarcoma development by acting as a molecular sponge to regulate miR-195. Oncotarget. vol 7. issue 50. 2018-02-22. PMID:27813492. |
moreover, silencing pvt1 by sirna inhibited bcl2, ccnd1, and fasn protein expression via mir-195 in osteosarcoma cells, and bcl2 inhibited the si-pvt1#1-induced apoptosis of u2os cells. |
2018-02-22 |
2023-08-13 |
Not clear |
| Juneyoung Jung, Jeongbin Seo, Joungmok Kim, Jeong Hee Ki. Ursolic Acid Causes Cell Death in PC-12 Cells by Inducing Apoptosis and Impairing Autophagy. Anticancer research. vol 38. issue 2. 2018-02-21. PMID:29374711. |
it also triggered apoptosis by reducing the level of b-cell lymphoma 2 (bcl2), activating caspase-3, and inducing cleavage of poly (adp-ribosyl) polymerase. |
2018-02-21 |
2023-08-13 |
Not clear |
| Yiyao Wang, Yu Li, Qunzhi Xing, Xuechan G Han, Xu Dong, Yiping Lu, Mintao Zho. Sevoflurane anesthesia in pregnant rats negatively affects nerve function in offspring potentially via inhibition of the Wnt/β-catenin pathway. Molecular medicine reports. vol 15. issue 5. 2018-02-16. PMID:28447764. |
western blot and reverse transcription‑quantitative polymerase chain reaction (rt‑qpcr) analyses were used to examine the expression of multiple critical factors associated with the proliferation and apoptosis of nerve cells, including ki67, nestin, b cell leukemia/lymphoma 2 (bcl-2), bcl2 associated x (bax) and caspase‑3. |
2018-02-16 |
2023-08-13 |
mouse |
| Rathinavel Ashokkumar, Sankar Jamuna, M S Sakeena Sadullah, S Niranjali Devara. Vitexin protects isoproterenol induced post myocardial injury by modulating hipposignaling and ER stress responses. Biochemical and biophysical research communications. vol 496. issue 2. 2018-02-16. PMID:29406244. |
iso mediated apoptosis was found to be associated with er permeabilization and characterized by enhanced production of ros, activation of caspase-3, modulation of bcl2 family proteins and activation of bnip3. |
2018-02-16 |
2023-08-13 |
Not clear |
| Gui-Cun Zhao, Yan-Ling Yuan, Feng-Rong Chai, Fa-Jing J. Effect of Melilotus officinalis extract on the apoptosis of brain tissues by altering cerebral thrombosis and inflammatory mediators in acute cerebral ischemia. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 89. 2018-02-14. PMID:28320101. |
moreover biochemical parameters in plasma such as 6-keto-pgf1α and txb2 and concentration of cytokine, oxidative stress, apoptosis ratio and protein expressions of bcl2 & bax were estimated in the brain tissues. |
2018-02-14 |
2023-08-13 |
rat |
| Nicholas E Shepherd, Rosemary S Harrison, Gloria Ruiz-Gomez, Giovanni Abbenante, Jody M Mason, David P Fairli. Downsizing the BAD BH3 peptide to small constrained α-helices with improved ligand efficiency. Organic & biomolecular chemistry. vol 14. issue 46. 2018-02-08. PMID:27819377. |
bcl2 homology (bh) proteins can either trigger or prevent programmed cell death or apoptosis. |
2018-02-08 |
2023-08-13 |
Not clear |
| Lumin Wang, Hongfei Sun, Xiaofei Wang, Ni Hou, Lingyu Zhao, Dongdong Tong, Kang He, Yang Yang, Tusheng Song, Jun Yang, Chen Huan. EGR1 mediates miR-203a suppress the hepatocellular carcinoma cells progression by targeting HOXD3 through EGFR signaling pathway. Oncotarget. vol 7. issue 29. 2018-02-06. PMID:27244890. |
silencing hoxd3 could block transition of the g2/m phase, increase cell apoptosis, decrease the expression of cell cycle and apoptosis-related proteins, egfr, p-akt, p-erk, ccnb1, cdk1 and bcl2 by targeting egfr through egfr/akt and erk cell signaling pathways. |
2018-02-06 |
2023-08-13 |
Not clear |
| Hassan Nazari, Abolfazl Shirazi, Naser Shams-Esfandabadi, Azita Afzali, Ebrahim Ahmad. The effect of amniotic membrane stem cells as donor nucleus on gene expression in reconstructed bovine oocytes. The International journal of developmental biology. vol 60. issue 4-6. 2018-01-31. PMID:27389982. |
the expression pattern of genes involved in self-renewal and pluripotency (pou5f1, sox2, nanog), imprinting (igf2, igf2r), dna methylation (dnmt1, dnmt3a), histone deacetylation (hdac2), and apoptosis (bax, bcl2) were evaluated in nt and ivf derived embryos. |
2018-01-31 |
2023-08-13 |
cattle |
| Chengfu Yuan, Changdong Wang, Junjie Wang, Vikas Kumar, Firoz Anwar, Fangxiang Xiao, Gohar Mushtaq, Yufei Liu, Mohammad Amjad Kamal, Ding Yua. Inhibition on the growth of human MDA-MB-231 breast cancer cells in vitro and tumor growth in a mouse xenograft model by Se-containing polysaccharides from Pyracantha fortuneana. Nutrition research (New York, N.Y.). vol 36. issue 11. 2018-01-31. PMID:27865619. |
in vitro studies showed that treatment of triple negative breast cancer (tnbc) mda-mb-231 cells with se-pfps (1) inhibited cell growth dose-dependently by arresting cells at g2 phase via inhibiting cdc25c-cyclinb1/cdc2 pathway; (2) caused apoptosis associated with increased p53, bax, puma and noxa, decreased bcl2, increased bax/bcl2 ratio and increased activities of caspases 3/9, suggesting its effect on p53-mediated cytochrome c-caspase pathway. |
2018-01-31 |
2023-08-13 |
mouse |
| Xianyu Zhang, Ying Lu, Xin Cao, Tao Zhen, Damian Kovalovsk. Zbtb1 prevents default myeloid differentiation of lymphoid-primed multipotent progenitors. Oncotarget. vol 7. issue 37. 2018-01-29. PMID:27542215. |
finally, biased myeloid differentiation of zbtb1-deficient lmpp cells was not due to increased p53-dependent apoptosis as it was not reverted by transgenic bcl2 expression or p53 deficiency. |
2018-01-29 |
2023-08-13 |
mouse |
| YanFang Zheng, Yin Zhao, QingQing Luo, XiaoXia Liu, XiaoPing Liu, Ying Hu, Li Zo. Edaravone protects against cobalt chloride-induced dysfunctions in apoptosis and invasion in trophoblast cells. Molecular reproduction and development. vol 83. issue 7. 2018-01-24. PMID:27128210. |
metrics of apoptosis included measurement of cysteine-aspartic acid protease 3 (casp3) activity as well as bax and bcl2 expression. |
2018-01-24 |
2023-08-13 |
Not clear |
| YanFang Zheng, Yin Zhao, QingQing Luo, XiaoXia Liu, XiaoPing Liu, Ying Hu, Li Zo. Edaravone protects against cobalt chloride-induced dysfunctions in apoptosis and invasion in trophoblast cells. Molecular reproduction and development. vol 83. issue 7. 2018-01-24. PMID:27128210. |
cocl2 inhibited the proliferation of h8 cells, promoted apoptosis, and up-regulated casp3 activation and bax expression while inhibiting bcl2 expression. |
2018-01-24 |
2023-08-13 |
Not clear |
| YanFang Zheng, Yin Zhao, QingQing Luo, XiaoXia Liu, XiaoPing Liu, Ying Hu, Li Zo. Edaravone protects against cobalt chloride-induced dysfunctions in apoptosis and invasion in trophoblast cells. Molecular reproduction and development. vol 83. issue 7. 2018-01-24. PMID:27128210. |
edaravone significantly increased h8 cell proliferation; inhibited apoptosis by down-regulating casp3 activation and bax production while promoting bcl2 stability; and ameliorated the migration and invasion phenotypes associated with cocl2 treatment. |
2018-01-24 |
2023-08-13 |
Not clear |
| Sharad Verma, Sukriti Goyal, Chetna Tyagi, Salma Jamal, Aditi Singh, Abhinav Grove. BIM (BCL-2 interacting mediator of cell death) SAHB (stabilized α helix of BCL2) not always convinces BAX (BCL-2-associated X protein) for apoptosis. Journal of molecular graphics & modelling. vol 67. 2018-01-19. PMID:27262527. |
bim (bcl-2 interacting mediator of cell death) sahb (stabilized α helix of bcl2) not always convinces bax (bcl-2-associated x protein) for apoptosis. |
2018-01-19 |
2023-08-13 |
Not clear |
| Sharad Verma, Sukriti Goyal, Chetna Tyagi, Salma Jamal, Aditi Singh, Abhinav Grove. BIM (BCL-2 interacting mediator of cell death) SAHB (stabilized α helix of BCL2) not always convinces BAX (BCL-2-associated X protein) for apoptosis. Journal of molecular graphics & modelling. vol 67. 2018-01-19. PMID:27262527. |
the interaction of bax (bcl-2-associated x protein) with bim (bcl-2 interacting mediator of cell death) sahb (stabilized α helix of bcl2) directly initiates bax-mediated mitochondrial apoptosis. |
2018-01-19 |
2023-08-13 |
Not clear |
| A A Guirguis, C I Slape, L M Failla, J Saw, C S Tremblay, D R Powell, F Rossello, A Wei, A Strasser, D J Curti. PUMA promotes apoptosis of hematopoietic progenitors driving leukemic progression in a mouse model of myelodysplasia. Cell death and differentiation. vol 23. issue 6. 2018-01-16. PMID:26742432. |
using the nup98-hoxd13 (nhd13) transgenic mouse model of mds, we previously reported that overexpression of the anti-apoptotic protein bcl2, blocked apoptosis and improved cytopenias, paradoxically, delaying leukemic progression. |
2018-01-16 |
2023-08-13 |
mouse |
| Tiening Zhang, Xun Cai, Qi Li, Peng Xue, Zhixiao Chen, Xiao Dong, Ying Xu. Hsa-miR-875-5p exerts tumor suppressor function through down-regulation of EGFR in colorectal carcinoma (CRC). Oncotarget. vol 7. issue 27. 2018-01-15. PMID:27302926. |
in addition, mir-875-5p induced apoptosis, as indicated by concomitantly with up-regulation of key apoptosis protein cleaved caspase-3, and down-regulation of anti-apoptosis protein bcl2. |
2018-01-15 |
2023-08-13 |
Not clear |