| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jike Song, Dadong Guo, Hongsheng B. Chlorogenic acid attenuates hydrogen peroxide‑induced oxidative stress in lens epithelial cells. International journal of molecular medicine. vol 41. issue 2. 2018-07-23. PMID:29207051. |
using mtt assay, reverse transcription‑quantitative polymerase chain reaction (rt‑qpcr) and elisa techniques, cell viability, and protein/mrna levels of bcl2 apoptosis regulator (bcl‑2) and bcl2 associated x apoptosis regulator (bax) were investigated. |
2018-07-23 |
2023-08-13 |
human |
| Terri J Harford, Greg Kliment, Girish C Shukla, Crystal M Weyma. The muscle regulatory transcription factor MyoD participates with p53 to directly increase the expression of the pro-apoptotic Bcl2 family member PUMA. Apoptosis : an international journal on programmed cell death. vol 22. issue 12. 2018-07-20. PMID:28918507. |
we have previously reported that myod is also necessary for the elevated expression of the pro-apoptotic bcl2 family member puma, and the ensuing apoptosis, that occurs in a subset of myoblasts induced to differentiate. |
2018-07-20 |
2023-08-13 |
Not clear |
| B Zhang, J Yi, C-L Zhang, Q-H Zhang, J-F Xu, H-Q Shen, D-W G. MiR-146a inhibits proliferation and induces apoptosis in murine osteoblastic MC3T3-E1 by regulating Bcl2. European review for medical and pharmacological sciences. vol 21. issue 17. 2018-07-16. PMID:28975995. |
mir-146a inhibits proliferation and induces apoptosis in murine osteoblastic mc3t3-e1 by regulating bcl2. |
2018-07-16 |
2023-08-13 |
Not clear |
| Yuri Pekarsky, Veronica Balatti, Carlo M Croc. BCL2 and miR-15/16: from gene discovery to treatment. Cell death and differentiation. vol 25. issue 1. 2018-07-16. PMID:28984869. |
since that time, many studies determined that bcl2 is one of the most important oncogenes involved in cancer by inhibiting apoptosis. |
2018-07-16 |
2023-08-13 |
Not clear |
| Yang-Hua Tang, Zhen-Shuang Yue, Da-Wei Xin, Lin-Ru Zeng, Zhen-Fei Xiong, Zhong-Qing Hu, Can-Da X. β‑Ecdysterone promotes autophagy and inhibits apoptosis in osteoporotic rats. Molecular medicine reports. vol 17. issue 1. 2018-07-16. PMID:29138818. |
additionally, pred was revealed to inhibit autophagy through the downregulation of beclin‑1, autophagy protein 5 and microtubule‑associated protein 1a/1b‑light chain 3i/ii expression, whereas it induced the apoptosis, through the activation of caspase‑3 and the suppression of apoptosis regulator bcl2 expression. |
2018-07-16 |
2023-08-13 |
rat |
| William R English, Heather Ireland-Zecchini, Andrew H Baker, Trevor D Littlewood, Martin R Bennett, Gillian Murph. Tissue Inhibitor of Metalloproteinase-3 (TIMP-3) induces FAS dependent apoptosis in human vascular smooth muscle cells. PloS one. vol 13. issue 4. 2018-07-13. PMID:29617412. |
timp-3 induced apoptosis did not cause mitochondrial depolarisation, increase activation of caspase-9 and was not inhibited by over-expression of b-cell lymphoma 2 (bcl2), indicating a mitochondrial independent/type-i death receptor pathway. |
2018-07-13 |
2023-08-13 |
human |
| Shu-Juan Wang, Wen-Ju Liu, Li-Ke Wang, Xun-Sheng Pang, Li-Guo Yan. The role of Melatonin receptor MTNR1A in the action of Melatonin on bovine granulosa cells. Molecular reproduction and development. vol 84. issue 11. 2018-07-09. PMID:28805353. |
our results indicated that melatonin inhibited gc apoptosis by up-regulating the expression of bcl2, bcl-xl, gpx4, and sod1, and down-regulating the expression of bax, casp3, and tp53. |
2018-07-09 |
2023-08-13 |
cattle |
| Xiaoying Chen, Nanzhen Kuang, Xiaoping Zeng, Zhiqin Zhang, Yanyan Li, Wei Liu, Yingyuan F. Effects of daphnetin combined with Bcl2‑siRNA on antiapoptotic genes in synovial fibroblasts of rats with collagen‑induced arthritis. Molecular medicine reports. vol 17. issue 1. 2018-07-09. PMID:29115552. |
the results suggested that si‑bcl combined with daphnetin may have an enhanced effect in promoting apoptosis of rafls derived from cia rats, and a possible underlying molecular mechanism may function through the downregulation of bcl2 expression and stat3, which is located upstream of bcl2 in the mitochondrial apoptotic pathway. |
2018-07-09 |
2023-08-13 |
rat |
| Prashanta Kumar Panda, Prajna Paramita Naik, Biswa Ranjan Meher, Durgesh Nandini Das, Subhadip Mukhopadhyay, Prakash Priyadarshi Praharaj, Tapas K Maiti, Sujit K Bhuti. PUMA dependent mitophagy by Abrus agglutinin contributes to apoptosis through ceramide generation. Biochimica et biophysica acta. Molecular cell research. vol 1865. issue 3. 2018-07-09. PMID:29229477. |
puma, a bh3-only pro-apoptotic bcl2 family protein, is known to translocate from the cytosol into the mitochondria in order to induce apoptosis. |
2018-07-09 |
2023-08-13 |
Not clear |
| Wantha Jenkhetkan, Sumon Thitiorul, Chalerm Jansom, Treetip Ratanavalacha. Molecular and cytogenetic effects of Thai royal jelly: modulation through c-MYC, h-TERT, NRF2, HO-1, BCL2, BAX and cyclins in human lymphocytes in vitro. Mutagenesis. vol 32. issue 5. 2018-07-03. PMID:28992336. |
rj treatment at 0.05 mg/ml increased cyclin e, bcl2 and bax to maximum levels indicating that throughout the active cell cycle, both cell survival and cell apoptosis increased. |
2018-07-03 |
2023-08-13 |
human |
| Katharina Mattes, Gerbrig Berger, Marjan Geugien, Edo Vellenga, Hein Scheper. CITED2 affects leukemic cell survival by interfering with p53 activation. Cell death & disease. vol 8. issue 10. 2018-07-02. PMID:29072699. |
in vitro, the reduction of cited2 resulted in increased p53-mediated apoptosis and cdkn1a expression, whereas bcl2 levels were reduced. |
2018-07-02 |
2023-08-13 |
mouse |
| Lloyd T Lam, Xiaoyu Lin, Emily J Faivre, Ziping Yang, Xiaoli Huang, Denise M Wilcox, Richard J Bellin, Sha Jin, Stephen K Tahir, Michael Mitten, Terry Magoc, Anahita Bhathena, Warren M Kati, Daniel H Albert, Yu Shen, Tamar Uzie. Vulnerability of Small-Cell Lung Cancer to Apoptosis Induced by the Combination of BET Bromodomain Proteins and BCL2 Inhibitors. Molecular cancer therapeutics. vol 16. issue 8. 2018-06-26. PMID:28468776. |
vulnerability of small-cell lung cancer to apoptosis induced by the combination of bet bromodomain proteins and bcl2 inhibitors. |
2018-06-26 |
2023-08-13 |
Not clear |
| Yujuan Xiao, Qingchun Diao, Yanhua Liang, Yusheng Peng, Kang Zen. MicroRNA‑24‑1‑5p promotes malignant melanoma cell autophagy and apoptosis via regulating ubiquitin D. Molecular medicine reports. vol 16. issue 6. 2018-06-26. PMID:28983594. |
the effects of mir‑24‑1‑5p overexpression on regulating the expressions of autophagy‑related proteins [microtubule‑associated protein 1a/1b‑light chain 3 (lc3)‑ii, lc3‑i and beclin‑1] and apoptosis‑related proteins [apoptosis regulator bcl‑2 (bcl‑2) and (bcl2 like 1) bcl‑xl] were investigated. |
2018-06-26 |
2023-08-13 |
human |
| Rui-Juan Zhuang, Jian Ma, Xiang Shi, Fei Ju, Shuang-Ping Ma, Lei Wang, Bin-Feng Cheng, Yan-Wen Ma, Mian Wang, Tong Li, Zhi-Wei Feng, Hai-Jie Yan. Cold-Inducible Protein RBM3 Protects UV Irradiation-Induced Apoptosis in Neuroblastoma Cells by Affecting p38 and JNK Pathways and Bcl2 Family Proteins. Journal of molecular neuroscience : MN. vol 63. issue 2. 2018-06-19. PMID:28831692. |
cold-inducible protein rbm3 protects uv irradiation-induced apoptosis in neuroblastoma cells by affecting p38 and jnk pathways and bcl2 family proteins. |
2018-06-19 |
2023-08-13 |
human |
| M A Rahman, S H Park, I J Y. Dog Sperm Cryopreservation in Glucose-Fructose or Sucrose Supplemented Glycerol-Free Tris: Effect of Post-Thaw Incubation Time on Gene Expression Related to Apoptosis and Motility. Cryo letters. vol 39. issue 1. 2018-06-12. PMID:29734414. |
objective: the study evaluated the effects of glucose-fructose or sucrose supplementation in glycerol-free tris (gft) solution on motility, viability, the level of reactive oxygen species (ros), as well as the level of apoptosis (bax and bcl2) and motility (smcp)-related gene expression of dog spermatozoa. |
2018-06-12 |
2023-08-13 |
dog |
| Yi-Chia Lin, Ji-Fan Lin, Te-Fu Tsai, Kuang-Yu Chou, Hung-En Chen, Thomas I-Sheng Hwan. Tumor suppressor miRNA-204-5p promotes apoptosis by targeting BCL2 in prostate cancer cells. Asian journal of surgery. vol 40. issue 5. 2018-06-11. PMID:27519795. |
tumor suppressor mirna-204-5p promotes apoptosis by targeting bcl2 in prostate cancer cells. |
2018-06-11 |
2023-08-13 |
human |
| Yi-Chia Lin, Ji-Fan Lin, Te-Fu Tsai, Kuang-Yu Chou, Hung-En Chen, Thomas I-Sheng Hwan. Tumor suppressor miRNA-204-5p promotes apoptosis by targeting BCL2 in prostate cancer cells. Asian journal of surgery. vol 40. issue 5. 2018-06-11. PMID:27519795. |
we hypothesized that mir-204-5p overexpression induces cancer cell apoptosis by repressing bcl2 expression. |
2018-06-11 |
2023-08-13 |
human |
| Qiuguo Han, Xin Xu, Jing Li, Jinggang Wang, Li Bai, Aihong Wang, Wei Wang, Bo Zhan. GATA4 is highly expressed in childhood acute lymphoblastic leukemia, promotes cell proliferation and inhibits apoptosis by activating BCL2 and MDM2. Molecular medicine reports. vol 16. issue 5. 2018-06-08. PMID:28849107. |
gata4 is highly expressed in childhood acute lymphoblastic leukemia, promotes cell proliferation and inhibits apoptosis by activating bcl2 and mdm2. |
2018-06-08 |
2023-08-13 |
mouse |
| Qiuguo Han, Xin Xu, Jing Li, Jinggang Wang, Li Bai, Aihong Wang, Wei Wang, Bo Zhan. GATA4 is highly expressed in childhood acute lymphoblastic leukemia, promotes cell proliferation and inhibits apoptosis by activating BCL2 and MDM2. Molecular medicine reports. vol 16. issue 5. 2018-06-08. PMID:28849107. |
bcl2 is a key anti‑apoptosis protein that was demonstrated to suppress cell apoptosis. |
2018-06-08 |
2023-08-13 |
mouse |
| Xuehua Xu, Chengliang Luo, Zhixiang Zhang, Jun Hu, Xiangting Gao, Yuanyi Zuo, Yun Wang, Shaohua Zh. Mdivi‑1 attenuates sodium azide‑induced apoptosis in H9c2 cardiac muscle cells. Molecular medicine reports. vol 16. issue 5. 2018-06-07. PMID:28849092. |
in addition, the expression of drp1 and of the apoptosis‑related proteins bcl2 apoptosis regulator (bcl‑2), and bcl2 associated x (bax) was determined by western blotting. |
2018-06-07 |
2023-08-13 |
Not clear |