| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Abu Musa Md Talimur Reza, Yun-Jung Choi, Hideyo Yasuda, Jin-Hoi Ki. Human adipose mesenchymal stem cell-derived exosomal-miRNAs are critical factors for inducing anti-proliferation signalling to A2780 and SKOV-3 ovarian cancer cells. Scientific reports. vol 6. 2018-06-04. PMID:27929108. |
furthermore, hamsc-cm-derived exosomes induced apoptosis signalling by upregulating different pro-apoptotic signalling molecules, such as bax, casp9, and casp3, as well as downregulating the anti-apoptotic protein bcl2. |
2018-06-04 |
2023-08-13 |
human |
| Min Jia, Zai-Bo Li, Lin Li, Hong-Tao Chu, Zhuang-Zhuang L. Role of matrix metalloproteinase‑7 and apoptosis‑associated gene expression levels in the pathogenesis of atrial fibrosis in a Beagle dog model. Molecular medicine reports. vol 16. issue 5. 2018-06-04. PMID:28901395. |
the aim of the present study was to investigate the potential role of matrix metalloproteinase‑7 (mmp‑7) and apoptosis‑associated genes [timp metallopeptidase inhibitor 2(timp‑2), bcl2 associated x, apoptosis regulator (bax) and bcl2, apoptosis regulator (bcl‑2)] in the pathogenesis of atrial fibrillation (af) in a beagle dog model. |
2018-06-04 |
2023-08-13 |
dog |
| M M R Chowdhury, Byung-Hyun Choi, Imran Khan, Kyeong-Lim Lee, Ayman Mesalam, Seok-Hwan Song, Lianguang Xu, Myeong-Don Joo, Fahmida Afrin, Il-Keun Kon. Supplementation of lycopene in maturation media improves bovine embryo quality in vitro. Theriogenology. vol 103. 2018-05-31. PMID:28800556. |
the percentages of mii-stage oocytes, the presumptive zygotes that underwent cleavage and developed into blastocysts were significantly (p < 0.05) higher, the intracellular ros concentrations reduced significantly (p < 0.05) in oocytes/blastocysts, tunel assay demonstrates reduced apoptosis and increased total cell number per blastocyst (p < 0.05), immunocytochemistry confirmed that diminished protein expression of nuclear factor kappa b (nfκb), cyclooxygenase-2 (cox2), and 8-oxoguanine (indicated by ros) and relative mrna expression of the caspase-3, nfκb, cox2, inos and bcl2-associated x (bax) was significantly (p < 0.05) lower whereas the anti-apoptotic gene bcl2 was significantly (p < 0.05) higher in the 0.2 μm lycopene-supplemented group than the control. |
2018-05-31 |
2023-08-13 |
cattle |
| Laurence Duplomb, Nathalie Droin, Olivier Bouchot, Christel Thauvin-Robinet, Ange-Line Bruel, Julien Thevenon, Patrick Callier, Guillaume Meurice, Noémie Pata-Merci, Romaric Loffroy, David Vandroux, Romain D A Costa, Virginie Carmignac, Eric Solary, Laurence Faivr. A constitutive BCL2 down-regulation aggravates the phenotype of PKD1-mutant-induced polycystic kidney disease. Human molecular genetics. vol 26. issue 23. 2018-05-24. PMID:28973148. |
the main identified function of bcl2 protein is to prevent cell death by apoptosis. |
2018-05-24 |
2023-08-13 |
mouse |
| Lijuan Zhang, Gang Feng, Xinyan Zhang, Yawen Ding, Xiaojuan Wan. microRNA‑630 promotes cell proliferation and inhibits apoptosis in the HCT116 human colorectal cancer cell line. Molecular medicine reports. vol 16. issue 4. 2018-05-21. PMID:28791386. |
furthermore, mir‑630 overexpression reduced the protein expression of p27, bcl2‑associated x apoptosis regulator, procaspase‑3 and active caspase‑3, and increased the levels of phosphorylated‑akt and bcl2 apoptosis regulator. |
2018-05-21 |
2023-08-13 |
human |
| Homa Mollaei, Reza Safaralizadeh, Esmaeil Babaei, Mohamad Reza Abedini, Reyhane Hoshya. The anti-proliferative and apoptotic effects of crocin on chemosensitive and chemoresistant cervical cancer cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 94. 2018-05-18. PMID:28763753. |
moreover, the genetic mechanism of crocin-induced apoptosis was accomplished by studying the relative expressions of p53, bax, bcl2 and mir-365, an upstream regulator of the last two ones. |
2018-05-18 |
2023-08-13 |
human |
| Effrosini G Panayotopoulou, Anna-Katharina Müller, Melanie Börries, Hauke Busch, Guohong Hu, Sima Le. Targeting of apoptotic pathways by SMAC or BH3 mimetics distinctly sensitizes paclitaxel-resistant triple negative breast cancer cells. Oncotarget. vol 8. issue 28. 2018-05-16. PMID:28187446. |
gene expression profiling of paclitaxel-residual, -resistant and naïve mda-mb-231 cells demonstrated that paclitaxel-residual, as opposed to -resistant cells, were characterized by an apoptotic signature, with downregulation of anti-apoptotic genes (bcl2, birc5), induction of apoptosis inducers (il24, pdcd4), and enrichment of tnfα/nf-κb pathway, including upregulation of tnfsf15, coupled with cell-cycle arrest. |
2018-05-16 |
2023-08-13 |
Not clear |
| Anna E Kowalczyk, Bartlomiej E Krazinski, Janusz Godlewski, Jolanta Kiewisz, Przemyslaw Kwiatkowski, Agnieszka Sliwinska-Jewsiewicka, Jacek Kiezun, Marian Sulik, Zbigniew Kmie. Expression of the EP300, TP53 and BAX genes in colorectal cancer: Correlations with clinicopathological parameters and survival. Oncology reports. vol 38. issue 1. 2018-05-15. PMID:28586030. |
e1a binding protein p300 (ep300), tumor protein p53 (tp53) and bcl2 associated x, apoptosis regulator (bax) genes encode proteins which cooperate to regulate important cellular processes. |
2018-05-15 |
2023-08-13 |
Not clear |
| Mohammed A El-Magd, Walied S Abdo, Mustafa El-Maddaway, Nasr M Nasr, Rasha A Gaber, Eman S El-Shetry, Ayman A Saleh, Faisal Abdulrahman Ali Alzahrani, Doaa H Abdelhad. High doses of S-methylcysteine cause hypoxia-induced cardiomyocyte apoptosis accompanied by engulfment of mitochondaria by nucleus. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 94. 2018-05-15. PMID:28783581. |
this centripetal movement of mitochondria accompanied by cardiomyocytes hypoxia-induced apoptosis as evident by increasing tunel positive cells as well as upregulation of apoptotic genes (caspase3 and bax), hypoxia inducible factor 1 alpha (hif1α), dynein light chain 1 (dynll1) and downregulation of the anti-apoptotic marker, bcl2. |
2018-05-15 |
2023-08-13 |
rat |
| Yang Han, Hang-Hang Jiang, Yu-Jing Zhang, Xing-Jia Hao, Yu-Zhe Sun, Rui-Qun Qi, Hong-Duo Chen, Xing-Hua Ga. Cell wall mannoprotein of Candida albicans induces cell cycle alternation and inhibits apoptosis of HaCaT cells via NF-κB signal pathway. Microbial pathogenesis. vol 111. 2018-05-15. PMID:28923602. |
mannoprotein also could inhibit apoptosis of hacat cells, which was well associated with increased expression of bcl2 (bcl-2). |
2018-05-15 |
2023-08-13 |
human |
| Yonggang Lyu, Xin Xu, Jun Yun, Jun Yi, Xin Li, Xianghua Liu, Rui Ling, Ling Wang, Jing Fa. [TNF-α regulates the proliferation of human breast cancer cells via regulation of ceramide content]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 33. issue 10. 2018-05-15. PMID:29169412. |
mtt assay was used to determine the proliferation of the cancer cells and western blotting was performed to measure the protein expressions of acid sphingomyelinase (asm), sphk1 and apoptosis or proliferation relevant factors including bcl2, bax and proliferating cell nuclear antigen (pcna). |
2018-05-15 |
2023-08-13 |
human |
| Ying Wu, Zhe Wang, Jing Kong, Jian Zhang, Rui Lin. [Aspirin inhibits the proliferation of breast cancer cells via inducing apoptosis and autophagy]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 33. issue 10. 2018-05-15. PMID:29169419. |
methods mtt assay was performed to detect the effect of aspirin on cell proliferation of cancer cells; flow cytometry was performed to assess the effect of aspirin on cell apoptosis; western blotting was used to determine the protein expressions of apoptosis-related proteins bcl2, cleaved caspase-3 (c-caspase-3), cleaved parp (c-parp) and autophagy-related gene 3 (atg3), lc3a, lc3b. |
2018-05-15 |
2023-08-13 |
human |
| Naimisha Beeravolu, Christina McKee, G Rasul Chaudhr. Mechanism of arsenite toxicity in embryonic stem cells. Journal of applied toxicology : JAT. vol 37. issue 10. 2018-05-10. PMID:28370166. |
although ias caused slight apoptosis with a concomitant increase in ros levels, the exposed escs had significant bcl2 expression, which could be involved in the protection against apoptosis. |
2018-05-10 |
2023-08-13 |
mouse |
| Hong-Yan Lu, Xiao-Qing Chen, Wei Tang, Qiu-Xia Wang, Jie Zhan. GRP78 silencing enhances hyperoxia-induced alveolar epithelial cell apoptosis via CHOP pathway. Molecular medicine reports. vol 16. issue 2. 2018-05-10. PMID:28586043. |
the overexpression of chop downregulated b‑cell lymphoma (bcl)‑2 expression levels, upregulated bcl2 associated x (bax), and increased apoptosis of a549 cells under conditions of hyperoxia. |
2018-05-10 |
2023-08-13 |
human |
| Satoko Arakawa, Masatsune Tsujioka, Tatsushi Yoshida, Hajime Tajima-Sakurai, Yuya Nishida, Yosuke Matsuoka, Ikuyo Yoshino, Yoshihide Tsujimoto, Shigeomi Shimiz. Role of Atg5-dependent cell death in the embryonic development of Bax/Bak double-knockout mice. Cell death and differentiation. vol 24. issue 9. 2018-05-07. PMID:28574506. |
members of the bcl2 family regulate apoptosis, among which bax and bak act as a mitochondrial gateway. |
2018-05-07 |
2023-08-13 |
mouse |
| Andrew W Roberts, Stephan Stilgenbauer, John F Seymour, David C S Huan. Venetoclax in Patients with Previously Treated Chronic Lymphocytic Leukemia. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 23. issue 16. 2018-04-30. PMID:28100580. |
acting as a pharmacologic mimic of the proteins that initiate apoptosis (a so-called bh3 mimetic), venetoclax rapidly induces apoptosis in chronic lymphocytic leukemia (cll) cells, which express high levels of bcl2 and rely on it to maintain their survival. |
2018-04-30 |
2023-08-13 |
Not clear |
| Kai-Hong Zhao, Can Zhang, Yue Bai, Yan Li, Xun Kang, Jian-Xin Chen, Kun Yao, Tao Jiang, Xiao-Song Zhong, Wen-Bin L. Antiglioma effects of cytarabine on leptomeningeal metastasis of high-grade glioma by targeting the PI3K/Akt/mTOR pathway. Drug design, development and therapy. vol 11. 2018-04-26. PMID:28721010. |
the present study confirmed that cytarabine inhibits proliferation and promotes apoptosis of u87 cells, and molecular analysis of this effect showed that cytarabine significantly reduces expression of phosphatidylinositol 3-kinase/serine/threonine kinase also known as the protein kinase b/mechanistic target of rapamycin (pi3k/akt/mtor) pathway, ki-67, bcl2, and 4-1bb, and upregulates bax and cleaved caspase-3. |
2018-04-26 |
2023-08-13 |
human |
| Luo-Cheng Li, Zhi-Wei Wang, Xiao-Ping Hu, Zhi-Yong Wu, Zhi-Peng Hu, Yong-Le Rua. MDG‑1 inhibits H2O2‑induced apoptosis and inflammation in human umbilical vein endothelial cells. Molecular medicine reports. vol 16. issue 3. 2018-04-24. PMID:28713956. |
in addition, pretreatment with mdg‑1 decreased the expression levels of proapoptotic proteins bcl2 associated x (bax) and caspase‑3, while it increased the expression levels of the antiapoptotic protein bcl2 apoptosis regulator (bcl‑2), compared with h2o2 treatment alone. |
2018-04-24 |
2023-08-13 |
human |
| Zhi Cheng, Zhanqiang Du, Yingchun Shang, Yuling Zhang, Tao Zhan. A Preliminary Study: PS1 Increases U1 snRNA Expression Associated with AD. Journal of molecular neuroscience : MN. vol 62. issue 3-4. 2018-04-23. PMID:28577205. |
importantly, the increased levels of bax, bcl2, and bax/bcl2 ratio showed that the overexpression of u1 snrna could cause cell apoptosis. |
2018-04-23 |
2023-08-13 |
Not clear |
| Wan Liang, Likai Ji, Yu Zhang, Yueran Zhen, Qingde Zhang, Xuewen Xu, Bang Li. Transcriptome Differences in Porcine Alveolar Macrophages from Tongcheng and Large White Pigs in Response to Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Infection. International journal of molecular sciences. vol 18. issue 7. 2018-04-17. PMID:28704922. |
for tc pig, 549 specific degs were identified, including vav2, bcl2 and bax, which were enriched in activation of leukocyte extravasation and suppression of apoptosis. |
2018-04-17 |
2023-08-13 |
Not clear |