| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Janina Dose, Almut Nebel, Stefanie Piegholdt, Gerald Rimbach, Patricia Huebb. Influence of the APOE genotype on hepatic stress response: Studies in APOE targeted replacement mice and human liver cells. Free radical biology & medicine. vol 96. 2018-01-09. PMID:27130033. |
therefore, we studied biomarkers of oxidative status (glutathione levels, 3-nitrotyrosine adducts, protein carbonyl concentration), er stress (xbp1(s), bip, ddit3), proteasome activity, mitochondrial function (respiratory complexes, atp levels and mitochondrial membrane potential as well as biomarkers of mitochondrial biogenesis, fission and fusion), autophagy (lc3, lamp2a), apoptosis (bcl2, bax, cycs) and dna damage in the liver of apoe targeted replacement (tr) mice and in huh7 hepatocytes overexpressing the apoe3 and the apoe4 isoform, respectively. |
2018-01-09 |
2023-08-13 |
mouse |
| Yunyan Pan, Yanling Zhang, Lijun Chen, Yan Liu, Yanlin Feng, Junyuan Ya. The Critical Role of Rab31 in Cell Proliferation and Apoptosis in Cancer Progression. Molecular neurobiology. vol 53. issue 7. 2018-01-08. PMID:26245486. |
meanwhile, rab31 inhibits u87 and siha cell apoptosis, and decreased the bax and pig3 expression, but enhanced bcl2 expression. |
2018-01-08 |
2023-08-13 |
Not clear |
| Chang-Ae Shin, Hyun-Woo Cho, A-Ri Shin, Hyun-Jung Sohn, Hyun-Il Cho, Tai-Gyu Ki. Co-expression of CD40L with CD70 or OX40L increases B-cell viability and antitumor efficacy. Oncotarget. vol 7. issue 29. 2018-01-08. PMID:27323820. |
notably, expression of cd40l augmented b-cell viability by inhibiting apoptosis through upregulated expression of the anti-apoptotic molecules bcl2, bcl-xl and bax. |
2018-01-08 |
2023-08-13 |
Not clear |
| Devora Champa, Arturo Orlacchio, Bindi Patel, Michela Ranieri, Anton A Shemetov, Vladislav V Verkhusha, Ana Maria Cuervo, Antonio Di Cristofan. Obatoclax kills anaplastic thyroid cancer cells by inducing lysosome neutralization and necrosis. Oncotarget. vol 7. issue 23. 2018-01-05. PMID:27144341. |
these tumors are intrinsically resistant to cell death, even when their driver oncogenic signaling pathways are inhibited.we have undertaken a detailed analysis, in mouse and human thyroid cancer cells, of the mechanism through which obatoclax, a pan-inhibitor of the anti-apoptotic proteins of the bcl2 family, effectively reduces tumor growth in vitro and in vivo.we demonstrate that obatoclax does not induce apoptosis, but rather necrosis of thyroid cancer cells, and that non-transformed thyroid cells are significantly less affected by this compound. |
2018-01-05 |
2023-08-13 |
mouse |
| Masoumeh Falah, Mohammad Najafi, Massoud Houshmand, Mohammad Farhad. Expression levels of the BAK1 and BCL2 genes highlight the role of apoptosis in age-related hearing impairment. Clinical interventions in aging. vol 11. 2018-01-05. PMID:27555755. |
expression levels of the bak1 and bcl2 genes highlight the role of apoptosis in age-related hearing impairment. |
2018-01-05 |
2023-08-13 |
human |
| Masoumeh Falah, Mohammad Najafi, Massoud Houshmand, Mohammad Farhad. Expression levels of the BAK1 and BCL2 genes highlight the role of apoptosis in age-related hearing impairment. Clinical interventions in aging. vol 11. 2018-01-05. PMID:27555755. |
in this study, we compared the expression of the genes bak1 and bcl2 as two arms of the intrinsic apoptosis pathway between patients with arhi and healthy subjects. |
2018-01-05 |
2023-08-13 |
human |
| Yuan Zhang, Kai Shen, Ying Bai, Xuan Lv, Rongrong Huang, Wei Zhang, Jie Chao, Lan K Nguyen, Jun Hua, Guangming Gan, Gang Hu, Honghong Ya. Mir143-BBC3 cascade reduces microglial survival via interplay between apoptosis and autophagy: Implications for methamphetamine-mediated neurotoxicity. Autophagy. vol 12. issue 9. 2017-12-29. PMID:27464000. |
bbc3 (bcl2 binding component 3) is a known apoptosis inducer; however, its role in microglial survival remains poorly understood. |
2017-12-29 |
2023-08-13 |
mouse |
| Cheng-Cao Sun, Shu-Jun Li, De-Jia L. Hsa-miR-134 suppresses non-small cell lung cancer (NSCLC) development through down-regulation of CCND1. Oncotarget. vol 7. issue 24. 2017-12-27. PMID:27166267. |
in addition, mir-134 induced apoptosis, as indicated by concomitantly with up-regulation of key apoptosis protein cleaved caspase-3, and down-regulation of anti-apoptosis protein bcl2. |
2017-12-27 |
2023-08-13 |
Not clear |
| Cheng-Yen Tsai, Su-Ying Wen, Shi-Yann Cheng, Chung-Hsing Wang, Yao-Chih Yang, Vijaya Padma Viswanadha, Chih-Yang Huang, Wei-Wen Ku. Nrf2 Activation as a Protective Feedback to Limit Cell Death in High Glucose-Exposed Cardiomyocytes. Journal of cellular biochemistry. vol 118. issue 7. 2017-12-27. PMID:27859591. |
knockdown of nrf2 by sirna transfection increased cleaved-caspase3, reduced bcl2 in the cellular protein level and further exacerbated hg-induced apoptosis. |
2017-12-27 |
2023-08-13 |
rat |
| Zachary R Hunter, Guang Yang, Lian Xu, Xia Liu, Jorge J Castillo, Steven P Treo. Genomics, Signaling, and Treatment of Waldenström Macroglobulinemia. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. vol 35. issue 9. 2017-12-27. PMID:28294689. |
deletions involving chromosome 6q are common and include genes that modulate nuclear factor-κb, bcl2, btk, apoptosis, differentiation, and arid1b. |
2017-12-27 |
2023-08-13 |
Not clear |
| Mouna Tabebi, Bodour Khabou, Hanen Boukadi, Mariam Ben Hamad, Bochra Ben Rhouma, Slim Tounsi, Abdellatif Maalej, Hassen Kamoun, Leila Keskes-Ammar, Mohamed Abid, Mouna Mnif, Faiza Fakhfak. Association study of apoptosis gene polymorphisms in mitochondrial diabetes: A potential role in the pathogenicity of MD. Gene. vol 639. 2017-12-27. PMID:28987347. |
we found 10 selected polymorphisms (p53 (rs1042522 and rs17878362), bcl2 (rs2279115), bax (rs1805419), bak1 (rs210132 and rs2227925), casp3 (rs1405937), casp7 (rs2227310), casp8 (rs1045485) and casp10 (rs13006529)) with a potential apoptosis effect in md patients compared to control population. |
2017-12-27 |
2023-08-13 |
Not clear |
| Mouna Tabebi, Bodour Khabou, Hanen Boukadi, Mariam Ben Hamad, Bochra Ben Rhouma, Slim Tounsi, Abdellatif Maalej, Hassen Kamoun, Leila Keskes-Ammar, Mohamed Abid, Mouna Mnif, Faiza Fakhfak. Association study of apoptosis gene polymorphisms in mitochondrial diabetes: A potential role in the pathogenicity of MD. Gene. vol 639. 2017-12-27. PMID:28987347. |
specifically, snps involved in the intrinsic pathway (p53, bcl2, bak1 and casp3) presented the highest risk of apoptosis. |
2017-12-27 |
2023-08-13 |
Not clear |
| Bhawna Chandravanshi, Ramesh Ramchandra Bhond. Shielding Engineered Islets With Mesenchymal Stem Cells Enhance Survival Under Hypoxia. Journal of cellular biochemistry. vol 118. issue 9. 2017-12-26. PMID:28098405. |
this was further accompanied by reduction in total reactive oxygen species, nitric oxide, and super oxide ions and down regulation of caspase3, caspase8, p53, and up regulation of bcl2 confirming prevention of apoptosis in icas. |
2017-12-26 |
2023-08-13 |
Not clear |
| Carsten Utoft Nieman. [Targeted treatment of chronic lymphocytic leukaemia]. Ugeskrift for laeger. vol 176. issue 15. 2017-12-20. PMID:25350143. |
apoptosis induction by inhibition of bcl2 with abt-199 is reported with likewise promising clinical results. |
2017-12-20 |
2023-08-13 |
Not clear |
| Yan Xiu, Wingel Y Xue, Allyn Lambertz, Mariah Leidinger, Katherine Gibson-Corley, Chen Zha. Constitutive Activation of NIK Impairs the Self-Renewal of Hematopoietic Stem/Progenitor Cells and Induces Bone Marrow Failure. Stem cells (Dayton, Ohio). vol 35. issue 3. 2017-12-19. PMID:27733012. |
many genes (mpl, tifab, emcn, flt3, bcl2, and others) that regulate hspc self-renewal, lineage commitment, and apoptosis are significantly downregulated-and those genes that regulate inflammatory responses and cell cycle inhibition (cdkn2a and cdkn2b) are significantly upregulated-by activation of nik. |
2017-12-19 |
2023-08-13 |
Not clear |
| D Scarlet, N Ille, R Ertl, B G Alves, G D A Gastal, S O Paiva, M O Gastal, E L Gastal, C Auric. Glucocorticoid metabolism in equine follicles and oocytes. Domestic animal endocrinology. vol 59. 2017-12-19. PMID:27866059. |
in cumulus cells, messenger rna expression of genes involved in glucocorticoid mechanism and apoptosis was either increased (nr3c1 and bcl2) or decreased (hsd11b2) by treatment (p < 0.01). |
2017-12-19 |
2023-08-13 |
Not clear |
| Takeshi Moriishi, Ryo Fukuyama, Toshihiro Miyazaki, Tatsuya Furuichi, Masako Ito, Toshihisa Komor. Overexpression of BCLXL in Osteoblasts Inhibits Osteoblast Apoptosis and Increases Bone Volume and Strength. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 31. issue 7. 2017-12-15. PMID:26852895. |
the bcl2 family proteins, bcl2 and bclxl, suppress apoptosis by preventing the release of caspase activators from mitochondria through the inhibition of bax subfamily proteins. |
2017-12-15 |
2023-08-13 |
mouse |
| Takeshi Moriishi, Ryo Fukuyama, Toshihiro Miyazaki, Tatsuya Furuichi, Masako Ito, Toshihisa Komor. Overexpression of BCLXL in Osteoblasts Inhibits Osteoblast Apoptosis and Increases Bone Volume and Strength. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 31. issue 7. 2017-12-15. PMID:26852895. |
we reported that bcl2 overexpression in osteoblasts using the 2.3 kb col1a1 promoter increased osteoblast proliferation, failed to reduce osteoblast apoptosis, inhibited osteoblast maturation, and reduced the number of osteocyte processes, leading to massive osteocyte death. |
2017-12-15 |
2023-08-13 |
mouse |
| Zhi-Bin Tong, Helena Hogberg, David Kuo, Srilatha Sakamuru, Menghang Xia, Lena Smirnova, Thomas Hartung, David Gerhol. Characterization of three human cell line models for high-throughput neuronal cytotoxicity screening. Journal of applied toxicology : JAT. vol 37. issue 2. 2017-12-15. PMID:27143523. |
gene expression results suggest that differentiating luhmes cells may be susceptible to apoptosis because they express low levels of anti-apoptotic genes bcl2 and birc5/survivin, whereas sh-sy5y cells may be resistant to apoptosis because they express high levels of bcl2, birc5/survivin, and birc3 genes. |
2017-12-15 |
2023-08-13 |
human |
| H Kocic, I Arsic, M Stankovic, D Tiodorovic, V Ciric, G Koci. Proliferative, anti-apoptotic and immune-enhancing effects of L-arginine in culture of skin fibroblasts. Journal of biological regulators and homeostatic agents. vol 31. issue 3. 2017-12-14. PMID:28954469. |
our current study was aimed to explore the effect of l-arginine on skin fibroblast (l929) signaling pathways involved in cell proliferation (akt-pakt kinase, erk/perk1/2 kinase, jnk/pjnk kinase and pstat-1), apoptosis (bcl2 and bax) and immune defense (nf-κb and cd26). |
2017-12-14 |
2023-08-13 |
Not clear |