| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jiusheng Deng, Dongkyoo Park, Mengchang Wang, Ajay Nooka, Qiaoya Deng, Shannon Matulis, Jonathan Kaufman, Sagar Lonial, Lawrence H Boise, Jacques Galipeau, Xingming Den. BCL2-BH4 antagonist BDA-366 suppresses human myeloma growth. Oncotarget. vol 7. issue 19. 2017-12-11. PMID:27049723. |
in this study, we demonstrated that bda-366 induces robust apoptosis in mm cell lines and primary mm cells by inducing bcl2 conformational change. |
2017-12-11 |
2023-08-13 |
mouse |
| J Cui, W J Placze. PTBP1 modulation of MCL1 expression regulates cellular apoptosis induced by antitubulin chemotherapeutics. Cell death and differentiation. vol 23. issue 10. 2017-12-11. PMID:27367564. |
myeloid cell leukemia sequence 1 (mcl1), an anti-apoptotic bcl2 family protein, is a key regulator of intrinsic apoptosis. |
2017-12-11 |
2023-08-13 |
Not clear |
| Ji Liang, Ruixiu Cao, Xiongjun Wang, Yajuan Zhang, Pan Wang, Hong Gao, Chen Li, Fan Yang, Rong Zeng, Ping Wei, Dawei Li, Wenfeng Li, Weiwei Yan. Mitochondrial PKM2 regulates oxidative stress-induced apoptosis by stabilizing Bcl2. Cell research. vol 27. issue 3. 2017-12-11. PMID:28035139. |
mitochondrial pkm2 regulates oxidative stress-induced apoptosis by stabilizing bcl2. |
2017-12-11 |
2023-08-13 |
human |
| Ji Liang, Ruixiu Cao, Xiongjun Wang, Yajuan Zhang, Pan Wang, Hong Gao, Chen Li, Fan Yang, Rong Zeng, Ping Wei, Dawei Li, Wenfeng Li, Weiwei Yan. Mitochondrial PKM2 regulates oxidative stress-induced apoptosis by stabilizing Bcl2. Cell research. vol 27. issue 3. 2017-12-11. PMID:28035139. |
replacement of wild-type bcl2 with phosphorylation-deficient bcl2 t69a mutant sensitizes glioma cells to oxidative stress-induced apoptosis and impairs brain tumor formation in an orthotopic xenograft model. |
2017-12-11 |
2023-08-13 |
human |
| Ji Liang, Ruixiu Cao, Xiongjun Wang, Yajuan Zhang, Pan Wang, Hong Gao, Chen Li, Fan Yang, Rong Zeng, Ping Wei, Dawei Li, Wenfeng Li, Weiwei Yan. Mitochondrial PKM2 regulates oxidative stress-induced apoptosis by stabilizing Bcl2. Cell research. vol 27. issue 3. 2017-12-11. PMID:28035139. |
our findings uncover a novel mechanism through which mitochondrial pkm2 phosphorylates bcl2 and inhibits apoptosis directly, highlight the essential role of pkm2 in ros adaptation of cancer cells, and implicate hsp90-pkm2-bcl2 axis as a potential target for therapeutic intervention in glioblastoma. |
2017-12-11 |
2023-08-13 |
human |
| L M Zhao, A X Pan. Iodine-131 treatment of thyroid cancer cells leads to suppression of cell proliferation followed by induction of cell apoptosis and cell cycle arrest by regulation of B-cell translocation gene 2-mediated JNK/NF-κB pathways. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 50. issue 1. 2017-12-08. PMID:28099584. |
an increase in cell viability by up-regulation in bcl2 gene, a decrease in apoptosis by enhanced cdk2 gene expression and a decrease in cell cycle arrest at g0/g1 phase were also observed in sw579 cell lines transfected with silenced btg2 gene. |
2017-12-08 |
2023-08-13 |
human |
| Helen O Oladapo, Michael Tarpley, Scott J Sauer, Kezia A Addo, Shalonda M Ingram, Dillon Strepay, Ben K Ehe, Lhoucine Chdid, Michael Trinkler, Jose R Roques, David B Darr, Jodie M Fleming, Gayathri R Devi, Kevin P William. Pharmacological targeting of GLI1 inhibits proliferation, tumor emboli formation and in vivo tumor growth of inflammatory breast cancer cells. Cancer letters. vol 411. 2017-12-05. PMID:28965853. |
in addition, gant61 and jk184 significantly down-regulated gli1 targets that regulate cell cycle (cyclin d and e) and apoptosis (bcl2). |
2017-12-05 |
2023-08-13 |
Not clear |
| Cheng-Cao Sun, Shu-Jun Li, Feng Zhang, Jing-Yu Pan, Liang Wang, Cui-Li Yang, Yong-Yong Xi, De Jia L. Hsa-miR-329 exerts tumor suppressor function through down-regulation of MET in non-small cell lung cancer. Oncotarget. vol 7. issue 16. 2017-12-04. PMID:26909600. |
in addition, mir-329 promoted nsclc cell apoptosis, as indicated by up-regulation of key apoptosis gene cleaved caspase-3, and down-regulation of anti-apoptosis gene bcl2. |
2017-12-04 |
2023-08-13 |
Not clear |
| Hélène Lenden Hasse, Chloé Lescale, Joy J Bianchi, Wei Yu, Marie Bedora-Faure, Ludovic Derian. Generation and CRISPR/Cas9 editing of transformed progenitor B cells as a pseudo-physiological system to study DNA repair gene function in V(D)J recombination. Journal of immunological methods. vol 451. 2017-12-04. PMID:28882611. |
in this system, the bcl2 transgene alleviates imatinib-induced apoptosis enabling the analysis of induced v(d)j recombination. |
2017-12-04 |
2023-08-13 |
mouse |
| Stephanie Berger, Erik Procko, Daciana Margineantu, Erinna F Lee, Betty W Shen, Alex Zelter, Daniel-Adriano Silva, Kusum Chawla, Marco J Herold, Jean-Marc Garnier, Richard Johnson, Michael J MacCoss, Guillaume Lessene, Trisha N Davis, Patrick S Stayton, Barry L Stoddard, W Douglas Fairlie, David M Hockenbery, David Bake. Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer. eLife. vol 5. 2017-11-24. PMID:27805565. |
many cancers overexpress one or more of the six human pro-survival bcl2 family proteins to evade apoptosis. |
2017-11-24 |
2023-08-13 |
human |
| Stephanie Berger, Erik Procko, Daciana Margineantu, Erinna F Lee, Betty W Shen, Alex Zelter, Daniel-Adriano Silva, Kusum Chawla, Marco J Herold, Jean-Marc Garnier, Richard Johnson, Michael J MacCoss, Guillaume Lessene, Trisha N Davis, Patrick S Stayton, Barry L Stoddard, W Douglas Fairlie, David M Hockenbery, David Bake. Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer. eLife. vol 5. 2017-11-24. PMID:27805565. |
to determine which bcl2 protein or proteins block apoptosis in different cancers, we computationally designed three-helix bundle protein inhibitors specific for each bcl2 pro-survival protein. |
2017-11-24 |
2023-08-13 |
human |
| Mariko Ishibashi, Hideto Tamura, Mika Sunakawa, Asaka Kondo-Onodera, Namiko Okuyama, Yasuko Hamada, Keiichi Moriya, Inhak Choi, Koji Tamada, Koiti Inokuch. Myeloma Drug Resistance Induced by Binding of Myeloma B7-H1 (PD-L1) to PD-1. Cancer immunology research. vol 4. issue 9. 2017-11-21. PMID:27440711. |
knockdown of b7-h1 expression in myeloma cells significantly inhibited cell proliferation and increased apoptosis induced by the chemotherapeutic alkylating agent melphalan, with downregulation of the expression of cell cycle-related genes (ccnd3 and cdk6) and antiapoptotic genes (bcl2 and mcl1). |
2017-11-21 |
2023-08-13 |
Not clear |
| Flavie Strappazzon, Anthea Di Rita, Valentina Cianfanelli, Melania D'Orazio, Francesca Nazio, Gian Maria Fimia, Francesco Ceccon. Prosurvival AMBRA1 turns into a proapoptotic BH3-like protein during mitochondrial apoptosis. Autophagy. vol 12. issue 6. 2017-11-13. PMID:27123694. |
indeed, we show that, in a proapoptotic positive feedback loop, the c-terminal part of ambra1, generated by casp/caspase cleavage upon apoptosis induction, inhibits the antiapoptotic factor bcl2 by a direct binding through its bh3-like domain. |
2017-11-13 |
2023-08-13 |
Not clear |
| A Di Rita, F Strappazzo. AMBRA1, a Novel BH3-Like Protein: New Insights Into the AMBRA1-BCL2-Family Proteins Relationship. International review of cell and molecular biology. vol 330. 2017-11-06. PMID:28215535. |
we found that the ambra1-bcl2 couple have a "dual role" in autophagy and apoptosis: the mitochondrial pool of bcl2 is able to inhibit ambra1-dependent autophagy, whereas in cell death conditions, the cleaved form of ambra1 (ambra1 |
2017-11-06 |
2023-08-13 |
Not clear |
| Joan Montero, Jason Stephansky, Tianyu Cai, Gabriel K Griffin, Lucia Cabal-Hierro, Katsuhiro Togami, Leah J Hogdal, Ilene Galinsky, Elizabeth A Morgan, Jon C Aster, Matthew S Davids, Nicole R LeBoeuf, Richard M Stone, Marina Konopleva, Naveen Pemmaraju, Anthony Letai, Andrew A Lan. Blastic Plasmacytoid Dendritic Cell Neoplasm Is Dependent on BCL2 and Sensitive to Venetoclax. Cancer discovery. vol 7. issue 2. 2017-11-03. PMID:27986708. |
we found that primary bpdcn cells were dependent on the antiapoptotic protein bcl2 and were uniformly sensitive to the bcl2 inhibitor venetoclax, as measured by direct cytotoxicity, apoptosis assays, and dynamic bh3 profiling. |
2017-11-03 |
2023-08-13 |
Not clear |
| Nesrine Lariche, Mesbah Lahouel, Lamia Benguedouar, Ammar Zellagu. Ferulenol, a Sesquiterpene Coumarin, Induce Apoptosis via Mitochondrial Dysregulation in Lung Cancer Induced by Benzo[a]pyrene: Involvement of Bcl2 Protein. Anti-cancer agents in medicinal chemistry. vol 17. issue 10. 2017-10-17. PMID:28270083. |
ferulenol, a sesquiterpene coumarin, induce apoptosis via mitochondrial dysregulation in lung cancer induced by benzo[a]pyrene: involvement of bcl2 protein. |
2017-10-17 |
2023-08-13 |
Not clear |
| Kangcheng Zhao, Yukun Zhang, Liang Kang, Yu Song, Kun Wang, Shuai Li, Xinghuo Wu, Wenbin Hua, Zengwu Shao, Shuhua Yang, Cao Yan. Epigenetic silencing of miRNA-143 regulates apoptosis by targeting BCL2 in human intervertebral disc degeneration. Gene. vol 628. 2017-10-09. PMID:28716711. |
epigenetic silencing of mirna-143 regulates apoptosis by targeting bcl2 in human intervertebral disc degeneration. |
2017-10-09 |
2023-08-13 |
human |
| Kangcheng Zhao, Yukun Zhang, Liang Kang, Yu Song, Kun Wang, Shuai Li, Xinghuo Wu, Wenbin Hua, Zengwu Shao, Shuhua Yang, Cao Yan. Epigenetic silencing of miRNA-143 regulates apoptosis by targeting BCL2 in human intervertebral disc degeneration. Gene. vol 628. 2017-10-09. PMID:28716711. |
after mirna-143 transfection, bcl2 expression and np cell apoptosis were assessed by using rt-pcr, western-blot, and flow cytometry. |
2017-10-09 |
2023-08-13 |
human |
| Kangcheng Zhao, Yukun Zhang, Liang Kang, Yu Song, Kun Wang, Shuai Li, Xinghuo Wu, Wenbin Hua, Zengwu Shao, Shuhua Yang, Cao Yan. Epigenetic silencing of miRNA-143 regulates apoptosis by targeting BCL2 in human intervertebral disc degeneration. Gene. vol 628. 2017-10-09. PMID:28716711. |
bcl2 knockdown reversed the effects of the mirna-143 inhibitor on nucleus pulposus apoptosis. |
2017-10-09 |
2023-08-13 |
human |
| Kangcheng Zhao, Yukun Zhang, Liang Kang, Yu Song, Kun Wang, Shuai Li, Xinghuo Wu, Wenbin Hua, Zengwu Shao, Shuhua Yang, Cao Yan. Epigenetic silencing of miRNA-143 regulates apoptosis by targeting BCL2 in human intervertebral disc degeneration. Gene. vol 628. 2017-10-09. PMID:28716711. |
our results suggest that mirna-143 promotes the progression of nucleus pulposus apoptosis by directly targeting bcl2, providing a potential therapeutic target for the treatment of intervertebral disc degeneration disease. |
2017-10-09 |
2023-08-13 |
human |