| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eleonora Ottina, Victor Peperzak, Katia Schoeler, Emma Carrington, Roswitha Sgonc, Marc Pellegrini, Simon Preston, Marco J Herold, Andreas Strasser, Andreas Villunge. DNA-binding of the Tet-transactivator curtails antigen-induced lymphocyte activation in mice. Nature communications. vol 8. issue 1. 2018-04-12. PMID:29044097. |
transactivator-mediated cytotoxicity depends on dna binding, but can be overcome by bcl2 overexpression, suggesting that apoptosis induction upon lymphocyte activation limits cellular and humoral immune responses. |
2018-04-12 |
2023-08-13 |
mouse |
| Arianna Bottoni, George A Cali. MicroRNAs as main players in the pathogenesis of chronic lymphocytic leukemia. MicroRNA (Shariqah, United Arab Emirates). vol 2. issue 3. 2018-04-11. PMID:25069439. |
micrornas (mirnas) are small noncoding rnas able to regulate the expression of many target genes, including the main apoptosis regulators bcl2 and mcl1. |
2018-04-11 |
2023-08-13 |
Not clear |
| Thoria I K Donia, Maria N Gerges, Tarek M Mohame. Amelioration effect of Egyptian sweet orange hesperidin on Ehrlich ascites carcinoma (EAC) bearing mice. Chemico-biological interactions. vol 285. 2018-04-10. PMID:29481770. |
moreover, hesperidin induced apoptosis of tumor cells which appeared as dna fragmentation by down-regulation of bcl2 as anti-apoptotic gene and stimulation of caspase3 and bax genes expression as apoptotic genes. |
2018-04-10 |
2023-08-13 |
mouse |
| Huiying Zhao, Qingchun Liu, Saisai Wang, Fang Dai, Xiaofei Cheng, Xiaobin Cheng, Wenbin Chen, Min Zhang, Dong Che. In vitro additive antitumor effects of dimethoxycurcumin and 5-fluorouracil in colon cancer cells. Cancer medicine. vol 6. issue 7. 2018-03-29. PMID:28573788. |
the induction of apoptosis is involved in the increasing of bax and cytochrome c and decreasing of bcl2 expressions. |
2018-03-29 |
2023-08-13 |
Not clear |
| Y Huang, S-H Liang, L-B Xiang, X-T Han, W Zhang, J Tang, X-H Wu, M-Q Zhan. [miR-218 Promoted the Apoptosis of Human Ovarian Carcinoma Cells via Suppression of the WNT/β-Catenin Signaling Pathway]. Molekuliarnaia biologiia. vol 51. issue 4. 2018-03-23. PMID:28900081. |
after over-expressing mir-218 in human ovarian carcinoma (ovcar3) cells, cell viability was determined by mtt method, cell apoptosis was observed by flow cytometry (fcm), mrna expression of mir-218, bcl2, bax was measured by rt-pcr and protein expression levels of wnt, tankyrase and β-catenin were quantified by western blots. |
2018-03-23 |
2023-08-13 |
human |
| X Qian, C Tan, B Yang, F Wang, Y Ge, Z Guan, J Ca. Astaxanthin increases radiosensitivity in esophageal squamous cell carcinoma through inducing apoptosis and G2/M arrest. Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus. vol 30. issue 6. 2018-03-14. PMID:28475750. |
it was shown that atx improved radiosensitivity of escc cells and induced apoptosis and g2/m arrest via inhibiting bcl2, cyclinb1, cdc2, and promoting bax expression. |
2018-03-14 |
2023-08-13 |
Not clear |
| Erica Anspach Will, Xiufang Liu, John J Pelus. AG 205, a progesterone receptor membrane component 1 antagonist, ablates progesterone's ability to block oxidative stress-induced apoptosis of human granulosa/luteal cells†. Biology of reproduction. vol 96. issue 4. 2018-03-12. PMID:28371915. |
harakiri is a bh-3 only member of the b-cell lymphoma 2 (bcl2) family that promotes apoptosis by binding to and antagonizing the antiapoptotic action of bcl2- and bcl2-like proteins. |
2018-03-12 |
2023-08-13 |
human |
| Patricia G Tremblay, Marc-André Sirar. Transcriptomic analysis of gene cascades involved in protein kinase A and C signaling in the KGN line of human ovarian granulosa tumor cells†. Biology of reproduction. vol 96. issue 4. 2018-03-12. PMID:28383663. |
gene associations with seven major ovarian functions were identified: prostaglandin- endoperoxide synthase 2 (ptgs2), interleukin 8 (il8), and interleukin 6 (il6) with inflammation; steroidogenic acute regulatory protein (star), cytochrome p450scc (cyp11a1), and cytochrome p450 family 19 subfamily a member 1 (cyp19a1) with steroidogenesis; vascular endothelial growth factor c (vegfc), vascular endothelial growth factor a (vegfa), and c-x-c chemokine receptor type 4 (cxcr4) with angiogenesis; amphiregulin (areg), epidermal growth factor receptor (egfr), and sprouty rtk signaling antagonist 2 (spry2) with differentiation, bcl2 associated x (bax), bcl2 like 12 (bcl2l12), and caspase 1(casp1) with apoptosis, cyclin d1 (ccnd1), cyclin b1 (ccnb1), and cyclin b2 (ccnb2) with division; and matrix metalloproteinase-1 (mmp1), matrix metallopeptidase 9 (mmp9), and timp metallopeptidase inhibitor 1 (timp1) with ovulation. |
2018-03-12 |
2023-08-13 |
human |
| Md Mostafizur Rahman, Rachael A Uson-Lopez, Md Tajuddin Sikder, Gongxun Tan, Toshiyuki Hosokawa, Takeshi Saito, Masaaki Kurasak. Ameliorative effects of selenium on arsenic-induced cytotoxicity in PC12 cells via modulating autophagy/apoptosis. Chemosphere. vol 196. 2018-03-12. PMID:29324385. |
furthermore, western blot analyses revealed that simultaneous exposure of both metals significantly inhibited autophagy which further suppressed apoptosis through positively regulation of key proteins; p-mtor, p-akt, p-foxo1a, p62, and expression of ubiquitin, bax, bcl2, nfкb, and caspases 3 and 9, although those are negatively regulated by arsenic. |
2018-03-12 |
2023-08-13 |
human |
| Yuan-Chin Lee, Ying-Jung Chen, Chia-Hui Huang, Long-Sen Chan. Amsacrine-induced apoptosis of human leukemia U937 cells is mediated by the inhibition of AKT- and ERK-induced stabilization of MCL1. Apoptosis : an international journal on programmed cell death. vol 22. issue 3. 2018-03-06. PMID:27757735. |
however, 9-aminoacridine derivatives, which have the same structural scaffold as amsacrine, induce cancer cell apoptosis by altering the expression of bcl2 family proteins. |
2018-03-06 |
2023-08-13 |
human |
| Jing Sun, Xin Zhang, Yang Sun, Zhi-Shu Tang, Dong-Yan Gu. Effects of Hylomecon vernalis ethanol extracts on cell cycle and apoptosis of colon cancer cells. Molecular medicine reports. vol 15. issue 6. 2018-03-05. PMID:28393197. |
in addition, hvmee induced apoptosis in ht‑29 and sw620 cells, by increasing caspase‑3, caspase‑9 and bcl2 associated x expression, and reducing bcl‑2 expression. |
2018-03-05 |
2023-08-13 |
human |
| Yanping Feng, Fang Liu, Zhixiang Du, Dongjie Zhao, Jianxin Cheng, Wei Gu. Wip1 regulates SKOV3 cell apoptosis through the p38 MAPK signaling pathway. Molecular medicine reports. vol 15. issue 6. 2018-03-05. PMID:28440479. |
western blot analysis was performed to determine expression of tumor protein 53 (p53), cleaved caspase‑3, caspase‑3, bcl2 associated x (bax), bcl2 apoptosis regulator (bcl‑2), p38 mitogen‑activated protein kinase (p38 mapk) and phosphorylated (p)‑p38 mapk. |
2018-03-05 |
2023-08-13 |
human |
| Emily K Sims, Alexander J Lakhter, Emily Anderson-Baucum, Tatsuyoshi Kono, Xin Tong, Carmella Evans-Molin. MicroRNA 21 targets BCL2 mRNA to increase apoptosis in rat and human beta cells. Diabetologia. vol 60. issue 6. 2018-02-28. PMID:28280903. |
microrna 21 targets bcl2 mrna to increase apoptosis in rat and human beta cells. |
2018-02-28 |
2023-08-13 |
human |
| V I Loginov, I V Pronina, A M Burdennyi, E A Pereyaslova, E A Braga, T P Kazubskaya, N E Kushlinski. Role of Methylation in the Regulation of Apoptosis Genes APAF1, DAPK1, and BCL2 in Breast Cancer. Bulletin of experimental biology and medicine. vol 162. issue 6. 2018-02-23. PMID:28429233. |
role of methylation in the regulation of apoptosis genes apaf1, dapk1, and bcl2 in breast cancer. |
2018-02-23 |
2023-08-13 |
Not clear |
| Quan Zhou, Fengli Chen, Jiali Zhao, Baojun Li, Yong Liang, Wei Pan, Shaoxian Zhang, Xinhong Wang, Donghui Zhen. Long non-coding RNA PVT1 promotes osteosarcoma development by acting as a molecular sponge to regulate miR-195. Oncotarget. vol 7. issue 50. 2018-02-22. PMID:27813492. |
moreover, silencing pvt1 by sirna inhibited bcl2, ccnd1, and fasn protein expression via mir-195 in osteosarcoma cells, and bcl2 inhibited the si-pvt1#1-induced apoptosis of u2os cells. |
2018-02-22 |
2023-08-13 |
Not clear |
| Juneyoung Jung, Jeongbin Seo, Joungmok Kim, Jeong Hee Ki. Ursolic Acid Causes Cell Death in PC-12 Cells by Inducing Apoptosis and Impairing Autophagy. Anticancer research. vol 38. issue 2. 2018-02-21. PMID:29374711. |
it also triggered apoptosis by reducing the level of b-cell lymphoma 2 (bcl2), activating caspase-3, and inducing cleavage of poly (adp-ribosyl) polymerase. |
2018-02-21 |
2023-08-13 |
Not clear |
| Yiyao Wang, Yu Li, Qunzhi Xing, Xuechan G Han, Xu Dong, Yiping Lu, Mintao Zho. Sevoflurane anesthesia in pregnant rats negatively affects nerve function in offspring potentially via inhibition of the Wnt/β-catenin pathway. Molecular medicine reports. vol 15. issue 5. 2018-02-16. PMID:28447764. |
western blot and reverse transcription‑quantitative polymerase chain reaction (rt‑qpcr) analyses were used to examine the expression of multiple critical factors associated with the proliferation and apoptosis of nerve cells, including ki67, nestin, b cell leukemia/lymphoma 2 (bcl-2), bcl2 associated x (bax) and caspase‑3. |
2018-02-16 |
2023-08-13 |
mouse |
| Rathinavel Ashokkumar, Sankar Jamuna, M S Sakeena Sadullah, S Niranjali Devara. Vitexin protects isoproterenol induced post myocardial injury by modulating hipposignaling and ER stress responses. Biochemical and biophysical research communications. vol 496. issue 2. 2018-02-16. PMID:29406244. |
iso mediated apoptosis was found to be associated with er permeabilization and characterized by enhanced production of ros, activation of caspase-3, modulation of bcl2 family proteins and activation of bnip3. |
2018-02-16 |
2023-08-13 |
Not clear |
| Gui-Cun Zhao, Yan-Ling Yuan, Feng-Rong Chai, Fa-Jing J. Effect of Melilotus officinalis extract on the apoptosis of brain tissues by altering cerebral thrombosis and inflammatory mediators in acute cerebral ischemia. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 89. 2018-02-14. PMID:28320101. |
moreover biochemical parameters in plasma such as 6-keto-pgf1α and txb2 and concentration of cytokine, oxidative stress, apoptosis ratio and protein expressions of bcl2 & bax were estimated in the brain tissues. |
2018-02-14 |
2023-08-13 |
rat |
| Nicholas E Shepherd, Rosemary S Harrison, Gloria Ruiz-Gomez, Giovanni Abbenante, Jody M Mason, David P Fairli. Downsizing the BAD BH3 peptide to small constrained α-helices with improved ligand efficiency. Organic & biomolecular chemistry. vol 14. issue 46. 2018-02-08. PMID:27819377. |
bcl2 homology (bh) proteins can either trigger or prevent programmed cell death or apoptosis. |
2018-02-08 |
2023-08-13 |
Not clear |