| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sun-A Ock, Yeon-Mi Lee, Ji-Sung Park, Sharath Belame Shivakumar, Seon-Woung Moon, Nak-Ju Sung, Won-Jae Lee, Si-Jung Jang, Ju-Mi Park, Seung-Chan Lee, Sung-Lim Lee, Gyu-Jin Rh. Evaluation of phenotypic, functional and molecular characteristics of porcine mesenchymal stromal/stem cells depending on donor age, gender and tissue source. The Journal of veterinary medical science. vol 78. issue 6. 2017-06-15. PMID:26922917. |
mscs were analyzed for alkaline phosphatase (ap) activity, cd90 and oct3/4 expression, in vitro differentiation ability, senescence-associated β-galactosidase (sa-β-gal) activity, telomeric properties, cell cycle status and expression of senescence (il6, c-myc, tgfβ, p53 and p21)- and apoptosis (bak and bcl2)-related proteins. |
2017-06-15 |
2023-08-13 |
Not clear |
| Alina Fedoseienko, Hylke W Wieringa, G Bea A Wisman, Evelien Duiker, Anna K L Reyners, Marten H Hofker, Ate G J van der Zee, Bart van de Sluis, Marcel A T M van Vug. Nuclear COMMD1 Is Associated with Cisplatin Sensitivity in Ovarian Cancer. PloS one. vol 11. issue 10. 2017-06-15. PMID:27788210. |
this was accompanied by a more effective g2/m checkpoint, and decreased protein expression of the dna repair gene brca1, and the apoptosis inhibitor bcl2. |
2017-06-15 |
2023-08-13 |
Not clear |
| Ji-Liang Zhang, Christopher Laurence Souders, Nancy D Denslow, Christopher J Martyniu. Quercetin, a natural product supplement, impairs mitochondrial bioenergetics and locomotor behavior in larval zebrafish (Danio rerio). Toxicology and applied pharmacology. vol 327. 2017-06-13. PMID:28450151. |
there were no changes in transcripts related to apoptosis (bcl2, bax, casp3, casp7), but we did observe a decrease in mrna levels for catalase (cat) in fish exposed to each dose, supporting an oxidative stress response. |
2017-06-13 |
2023-08-13 |
cat |
| Xiaomin Zhong, Lan Zheng, Jianfeng Shen, Dongmei Zhang, Minmin Xiong, Youyou Zhang, Xinhong He, Janos L Tanyi, Feng Yang, Kathleen T Montone, Xiaojun Chen, Congjian Xu, Andy P Xiang, Qihong Huang, Xiaowei Xu, Lin Zhan. Suppression of MicroRNA 200 Family Expression by Oncogenic KRAS Activation Promotes Cell Survival and Epithelial-Mesenchymal Transition in KRAS-Driven Cancer. Molecular and cellular biology. vol 36. issue 21. 2017-06-12. PMID:27550813. |
restoration of mir-200 expression compromised kras-induced cellular transformation in vitro and tumor formation in vivo in addition, we found that enforced expression of mir-200 abrogated kras-induced resistance to apoptosis by directly targeting the antiapoptotic gene bcl2 finally, mir-200 was able to antagonize the epithelial-mesenchymal transition (emt) driven by mutant kras. |
2017-06-12 |
2023-08-13 |
human |
| Federica Rizzo, Dario Ronchi, Sabrina Salani, Monica Nizzardo, Francesco Fortunato, Andreina Bordoni, Giulia Stuppia, Roberto Del Bo, Daniela Piga, Romana Fato, Nereo Bresolin, Giacomo P Comi, Stefania Cort. Selective mitochondrial depletion, apoptosis resistance, and increased mitophagy in human Charcot-Marie-Tooth 2A motor neurons. Human molecular genetics. vol 25. issue 19. 2017-06-09. PMID:27506976. |
p53, bax, caspase 8, cleaved caspase 3, and the anti-apoptotic marker bcl2) demonstrated that cmt2a-mns are more resistant to apoptosis than wild-type mns. |
2017-06-09 |
2023-08-13 |
human |
| Stephan Stilgenbauer, Barbara Eichhorst, Johannes Schetelig, Steven Coutre, John F Seymour, Talha Munir, Soham D Puvvada, Clemens-Martin Wendtner, Andrew W Roberts, Wojciech Jurczak, Stephen P Mulligan, Sebastian Böttcher, Mehrdad Mobasher, Ming Zhu, Monali Desai, Brenda Chyla, Maria Verdugo, Sari Heitner Enschede, Elisa Cerri, Rod Humerickhouse, Gary Gordon, Michael Hallek, William G Wierd. Venetoclax in relapsed or refractory chronic lymphocytic leukaemia with 17p deletion: a multicentre, open-label, phase 2 study. The Lancet. Oncology. vol 17. issue 6. 2017-06-05. PMID:27178240. |
venetoclax is an oral small-molecule bcl2 inhibitor that induces chronic lymphocytic leukaemia cell apoptosis. |
2017-06-05 |
2023-08-13 |
Not clear |
| Selma Tuzlak, Thomas Kaufmann, Andreas Villunge. Interrogating the relevance of mitochondrial apoptosis for vertebrate development and postnatal tissue homeostasis. Genes & development. vol 30. issue 19. 2017-06-05. PMID:27798841. |
many of these studies were geared toward understanding the role of bcl2 family proteins and mitochondrial apoptosis in disease, whereas fewer focused in detail on their role during normal development or tissue homeostasis, perhaps also due to an irritating lack of phenotype. |
2017-06-05 |
2023-08-13 |
mouse |
| Liza J Burton, Mariela Rivera, Ohuod Hawsawi, Jin Zou, Tamaro Hudson, Guangdi Wang, Qiang Zhang, Luis Cubano, Nawal Boukli, Valerie Odero-Mara. Muscadine Grape Skin Extract Induces an Unfolded Protein Response-Mediated Autophagy in Prostate Cancer Cells: A TMT-Based Quantitative Proteomic Analysis. PloS one. vol 11. issue 10. 2017-05-31. PMID:27755556. |
the up-regulation of pro-apoptotic markers parp, caspase-12, cleaved caspase-3, -7, bax and down-regulation of anti-apoptotic marker bcl2 was confirmed by western blot analysis and apoptosis was visualized by increased tunel/annexin v staining upon mske treatment. |
2017-05-31 |
2023-08-13 |
Not clear |
| Supriya V Vartak, Divyaanka Iyer, T R Santhoshkumar, Sheetal Sharma, Archita Mishra, Gunaseelan Goldsmith, Mrinal Srivastava, Shikha Srivastava, Subhas S Karki, Avadhesha Surolia, Bibha Choudhary, Sathees C Raghava. Novel BCL2 inhibitor, Disarib induces apoptosis by disruption of BCL2-BAK interaction. Biochemical pharmacology. vol 131. 2017-05-29. PMID:28223017. |
novel bcl2 inhibitor, disarib induces apoptosis by disruption of bcl2-bak interaction. |
2017-05-29 |
2023-08-13 |
Not clear |
| Lixian Cheng, Hui Shi, Yan Jin, Xiaoxi Li, Jinshun Pan, Yimei Lai, Yan Lin, Ya Jin, Gaurab Roy, Allan Zhao, Fanghong L. Adiponectin Deficiency Leads to Female Subfertility and Ovarian Dysfunctions in Mice. Endocrinology. vol 157. issue 12. 2017-05-26. PMID:27700136. |
adiponectin deficiency also altered the peak concentrations of lh surge and led to lower expression of cytochrome p450 family 11 subfamily a member 1 (p450scc), an enzyme critical for progesterone synthesis, as well as an increase in bcl2 associated x, apoptosis regulator and insulin like growth factor binding protein 4 in atretic follicles. |
2017-05-26 |
2023-08-13 |
mouse |
| Xiaoling Guo, Deliang Zhu, Ruiling Lian, Yuting Han, Yonglong Guo, Zhijie Li, Shibo Tang, Jiansu Che. Matrigel and Activin A promote cell-cell contact and anti-apoptotic activity in cultured human retinal pigment epithelium cells. Experimental eye research. vol 147. 2017-05-25. PMID:27130547. |
moreover, ma treatment decreased apoptotic cells, ros and bax and increased △Ψ m and bcl2 in hrpe cells under serum withdrawal-induced apoptosis. |
2017-05-25 |
2023-08-13 |
human |
| Ntube N O Ngalame, Ngome L Makia, Michael P Waalkes, Erik J Toka. Mitigation of arsenic-induced acquired cancer phenotype in prostate cancer stem cells by miR-143 restoration. Toxicology and applied pharmacology. vol 312. 2017-05-23. PMID:26721309. |
increased apoptosis was associated with decreased bcl2 and bcl-xl expression. |
2017-05-23 |
2023-08-13 |
human |
| M A Crookenden, A Heiser, A Murray, V S R Dukkipati, J K Kay, J J Loor, S Meier, M D Mitchell, K M Moyes, C G Walker, J R Roch. Parturition in dairy cows temporarily alters the expression of genes in circulating neutrophils. Journal of dairy science. vol 99. issue 8. 2017-05-12. PMID:27179873. |
genes that were differentially expressed over the transition period included those involved in neutrophil adhesion (sell, itgb2, and itgbx), mediation of the immune response (tlr4, hla-dra, and cxcr2), maturation, cell cycle progression, apoptosis (mcl1, bcl2, faslg, and ripk1), and control of gene expression (pparg, ppard, and stat3). |
2017-05-12 |
2023-08-13 |
Not clear |
| Supriya V Vartak, Mahesh Hegde, Divyaanka Iyer, Snehal Gaikwad, Vidya Gopalakrishnan, Mrinal Srivastava, Subhas S Karki, Bibha Choudhary, Pritha Ray, T R Santhoshkumar, Sathees C Raghava. A novel inhibitor of BCL2, Disarib abrogates tumor growth while sparing platelets, by activating intrinsic pathway of apoptosis. Biochemical pharmacology. vol 122. 2017-05-09. PMID:27693384. |
a novel inhibitor of bcl2, disarib abrogates tumor growth while sparing platelets, by activating intrinsic pathway of apoptosis. |
2017-05-09 |
2023-08-13 |
mouse |
| Rabia Johnson, Phiwayinkosi V Dludla, Christo J F Muller, Barbara Huisamen, M Faadiel Essop, Johan Lou. The Transcription Profile Unveils the Cardioprotective Effect of Aspalathin against Lipid Toxicity in an In Vitro H9c2 Model. Molecules (Basel, Switzerland). vol 22. issue 2. 2017-05-09. PMID:28146135. |
aspalathin was able to modulate key regulators associated with lipid metabolism (adipoq, apob, cd36, cpt1, pparγ, srebf1/2, scd1 and vldlr), insulin resistance (igf1, akt1, pde3 and map2k1), inflammation (il3, il6, jak2, lepr, socs3, and tnf13) and apoptosis (bcl2 and chuk). |
2017-05-09 |
2023-08-13 |
Not clear |
| Rabia Johnson, Phiwayinkosi V Dludla, Christo J F Muller, Barbara Huisamen, M Faadiel Essop, Johan Lou. The Transcription Profile Unveils the Cardioprotective Effect of Aspalathin against Lipid Toxicity in an In Vitro H9c2 Model. Molecules (Basel, Switzerland). vol 22. issue 2. 2017-05-09. PMID:28146135. |
collectively, our results suggest that aspalathin could reverse metabolic abnormalities by activating adipoq while modulating the expression of pparγ and srebf1/2, decreasing inflammation via il6/jak2 pathway, which together with an observed increased expression of bcl2 prevents myocardium apoptosis. |
2017-05-09 |
2023-08-13 |
Not clear |
| Samira Hajiaghalou, Bita Ebrahimi, Abdolhossein Shahverdi, Mina Sharbatoghli, Nasim Beigi Boroujen. Comparison of apoptosis pathway following the use of two protocols for vitrification of immature mouse testicular tissue. Theriogenology. vol 86. issue 8. 2017-05-08. PMID:27492762. |
morphology, cell viability, apoptosis incidence, and apoptosis gene expression (bax, bcl2, caspase 3, fas, fas ligand, p53) were evaluated at 0, 3, and 20 hours of culture by light microscopy, flow cytometry, and real-time polymerase chain reaction, respectively. |
2017-05-08 |
2023-08-13 |
mouse |
| Yogesh M Kulkarni, Vivek Kaushik, Neelam Azad, Clayton Wright, Yon Rojanasakul, George O'Doherty, Anand Krishnan V Iye. Autophagy-Induced Apoptosis in Lung Cancer Cells by a Novel Digitoxin Analog. Journal of cellular physiology. vol 231. issue 4. 2017-05-01. PMID:26264876. |
we investigated monod-dependent regulation of akt and bcl2, proteins that are known regulators of both autophagy and apoptosis. |
2017-05-01 |
2023-08-13 |
Not clear |
| Yanping Zhu, Yanxia Fu, Hairong Li. Baicalin Inhibits Renal Cell Apoptosis and Protects Against Acute Kidney Injury in Pediatric Sepsis. Medical science monitor : international medical journal of experimental and clinical research. vol 22. 2017-04-28. PMID:28013315. |
mouse sepsis models were constructed by cecal ligation and puncture (clp) and treated with baicalin intragastrically, after which bun and cr examination, tunel apoptosis assay, and expression analyses of bax and bcl2 were performed. |
2017-04-28 |
2023-08-13 |
mouse |
| Yanping Zhu, Yanxia Fu, Hairong Li. Baicalin Inhibits Renal Cell Apoptosis and Protects Against Acute Kidney Injury in Pediatric Sepsis. Medical science monitor : international medical journal of experimental and clinical research. vol 22. 2017-04-28. PMID:28013315. |
it inhibited bax and promoted bcl2 in the renal tissue, which was consistent with cell apoptosis changes. |
2017-04-28 |
2023-08-13 |
mouse |