| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stephanie Berger, Erik Procko, Daciana Margineantu, Erinna F Lee, Betty W Shen, Alex Zelter, Daniel-Adriano Silva, Kusum Chawla, Marco J Herold, Jean-Marc Garnier, Richard Johnson, Michael J MacCoss, Guillaume Lessene, Trisha N Davis, Patrick S Stayton, Barry L Stoddard, W Douglas Fairlie, David M Hockenbery, David Bake. Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer. eLife. vol 5. 2017-11-24. PMID:27805565. |
many cancers overexpress one or more of the six human pro-survival bcl2 family proteins to evade apoptosis. |
2017-11-24 |
2023-08-13 |
human |
| Stephanie Berger, Erik Procko, Daciana Margineantu, Erinna F Lee, Betty W Shen, Alex Zelter, Daniel-Adriano Silva, Kusum Chawla, Marco J Herold, Jean-Marc Garnier, Richard Johnson, Michael J MacCoss, Guillaume Lessene, Trisha N Davis, Patrick S Stayton, Barry L Stoddard, W Douglas Fairlie, David M Hockenbery, David Bake. Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer. eLife. vol 5. 2017-11-24. PMID:27805565. |
to determine which bcl2 protein or proteins block apoptosis in different cancers, we computationally designed three-helix bundle protein inhibitors specific for each bcl2 pro-survival protein. |
2017-11-24 |
2023-08-13 |
human |
| Mariko Ishibashi, Hideto Tamura, Mika Sunakawa, Asaka Kondo-Onodera, Namiko Okuyama, Yasuko Hamada, Keiichi Moriya, Inhak Choi, Koji Tamada, Koiti Inokuch. Myeloma Drug Resistance Induced by Binding of Myeloma B7-H1 (PD-L1) to PD-1. Cancer immunology research. vol 4. issue 9. 2017-11-21. PMID:27440711. |
knockdown of b7-h1 expression in myeloma cells significantly inhibited cell proliferation and increased apoptosis induced by the chemotherapeutic alkylating agent melphalan, with downregulation of the expression of cell cycle-related genes (ccnd3 and cdk6) and antiapoptotic genes (bcl2 and mcl1). |
2017-11-21 |
2023-08-13 |
Not clear |
| Flavie Strappazzon, Anthea Di Rita, Valentina Cianfanelli, Melania D'Orazio, Francesca Nazio, Gian Maria Fimia, Francesco Ceccon. Prosurvival AMBRA1 turns into a proapoptotic BH3-like protein during mitochondrial apoptosis. Autophagy. vol 12. issue 6. 2017-11-13. PMID:27123694. |
indeed, we show that, in a proapoptotic positive feedback loop, the c-terminal part of ambra1, generated by casp/caspase cleavage upon apoptosis induction, inhibits the antiapoptotic factor bcl2 by a direct binding through its bh3-like domain. |
2017-11-13 |
2023-08-13 |
Not clear |
| A Di Rita, F Strappazzo. AMBRA1, a Novel BH3-Like Protein: New Insights Into the AMBRA1-BCL2-Family Proteins Relationship. International review of cell and molecular biology. vol 330. 2017-11-06. PMID:28215535. |
we found that the ambra1-bcl2 couple have a "dual role" in autophagy and apoptosis: the mitochondrial pool of bcl2 is able to inhibit ambra1-dependent autophagy, whereas in cell death conditions, the cleaved form of ambra1 (ambra1 |
2017-11-06 |
2023-08-13 |
Not clear |
| Joan Montero, Jason Stephansky, Tianyu Cai, Gabriel K Griffin, Lucia Cabal-Hierro, Katsuhiro Togami, Leah J Hogdal, Ilene Galinsky, Elizabeth A Morgan, Jon C Aster, Matthew S Davids, Nicole R LeBoeuf, Richard M Stone, Marina Konopleva, Naveen Pemmaraju, Anthony Letai, Andrew A Lan. Blastic Plasmacytoid Dendritic Cell Neoplasm Is Dependent on BCL2 and Sensitive to Venetoclax. Cancer discovery. vol 7. issue 2. 2017-11-03. PMID:27986708. |
we found that primary bpdcn cells were dependent on the antiapoptotic protein bcl2 and were uniformly sensitive to the bcl2 inhibitor venetoclax, as measured by direct cytotoxicity, apoptosis assays, and dynamic bh3 profiling. |
2017-11-03 |
2023-08-13 |
Not clear |
| Nesrine Lariche, Mesbah Lahouel, Lamia Benguedouar, Ammar Zellagu. Ferulenol, a Sesquiterpene Coumarin, Induce Apoptosis via Mitochondrial Dysregulation in Lung Cancer Induced by Benzo[a]pyrene: Involvement of Bcl2 Protein. Anti-cancer agents in medicinal chemistry. vol 17. issue 10. 2017-10-17. PMID:28270083. |
ferulenol, a sesquiterpene coumarin, induce apoptosis via mitochondrial dysregulation in lung cancer induced by benzo[a]pyrene: involvement of bcl2 protein. |
2017-10-17 |
2023-08-13 |
Not clear |
| Kangcheng Zhao, Yukun Zhang, Liang Kang, Yu Song, Kun Wang, Shuai Li, Xinghuo Wu, Wenbin Hua, Zengwu Shao, Shuhua Yang, Cao Yan. Epigenetic silencing of miRNA-143 regulates apoptosis by targeting BCL2 in human intervertebral disc degeneration. Gene. vol 628. 2017-10-09. PMID:28716711. |
epigenetic silencing of mirna-143 regulates apoptosis by targeting bcl2 in human intervertebral disc degeneration. |
2017-10-09 |
2023-08-13 |
human |
| Kangcheng Zhao, Yukun Zhang, Liang Kang, Yu Song, Kun Wang, Shuai Li, Xinghuo Wu, Wenbin Hua, Zengwu Shao, Shuhua Yang, Cao Yan. Epigenetic silencing of miRNA-143 regulates apoptosis by targeting BCL2 in human intervertebral disc degeneration. Gene. vol 628. 2017-10-09. PMID:28716711. |
after mirna-143 transfection, bcl2 expression and np cell apoptosis were assessed by using rt-pcr, western-blot, and flow cytometry. |
2017-10-09 |
2023-08-13 |
human |
| Kangcheng Zhao, Yukun Zhang, Liang Kang, Yu Song, Kun Wang, Shuai Li, Xinghuo Wu, Wenbin Hua, Zengwu Shao, Shuhua Yang, Cao Yan. Epigenetic silencing of miRNA-143 regulates apoptosis by targeting BCL2 in human intervertebral disc degeneration. Gene. vol 628. 2017-10-09. PMID:28716711. |
bcl2 knockdown reversed the effects of the mirna-143 inhibitor on nucleus pulposus apoptosis. |
2017-10-09 |
2023-08-13 |
human |
| Kangcheng Zhao, Yukun Zhang, Liang Kang, Yu Song, Kun Wang, Shuai Li, Xinghuo Wu, Wenbin Hua, Zengwu Shao, Shuhua Yang, Cao Yan. Epigenetic silencing of miRNA-143 regulates apoptosis by targeting BCL2 in human intervertebral disc degeneration. Gene. vol 628. 2017-10-09. PMID:28716711. |
our results suggest that mirna-143 promotes the progression of nucleus pulposus apoptosis by directly targeting bcl2, providing a potential therapeutic target for the treatment of intervertebral disc degeneration disease. |
2017-10-09 |
2023-08-13 |
human |
| Dan-Dan Li, Zhi Luo, Guang-Hui Chen, Yu-Feng Song, Chuan-Chuan Wei, Ya-Xiong Pa. Identification of apoptosis-related genes Bcl2 and Bax from yellow catfish Pelteobagrus fulvidraco and their transcriptional responses to waterborne and dietborne zinc exposure. Gene. vol 633. 2017-09-29. PMID:28864113. |
to this end, we cloned full-length cdna sequences of bcl2 and three bax subtypes involved in apoptosis in p. fulvidraco, explored their mrna expressions in responses to different zn exposure pathways. |
2017-09-29 |
2023-08-13 |
Not clear |
| Dan-Dan Li, Zhi Luo, Guang-Hui Chen, Yu-Feng Song, Chuan-Chuan Wei, Ya-Xiong Pa. Identification of apoptosis-related genes Bcl2 and Bax from yellow catfish Pelteobagrus fulvidraco and their transcriptional responses to waterborne and dietborne zinc exposure. Gene. vol 633. 2017-09-29. PMID:28864113. |
for the first time, we characterized the full-length cdna sequences of bcl2 and three bax subtypes, determined their expression profiles and transcriptional responses to different zn exposure pathways, which would contribute to our understanding of the molecular basis of apoptosis, and also provide new insights into physiological responses to different zn exposure pathways. |
2017-09-29 |
2023-08-13 |
Not clear |
| V M Patel, K Balakrishnan, M Douglas, T Tibbitts, E Y Xu, J L Kutok, M Ayers, A Sarkar, R Guerrieri, W G Wierda, S O'Brien, N Jain, H M Stern, V Gandh. Duvelisib treatment is associated with altered expression of apoptotic regulators that helps in sensitization of chronic lymphocytic leukemia cells to venetoclax (ABT-199). Leukemia. vol 31. issue 9. 2017-09-28. PMID:28017967. |
the bcl2 inhibitor venetoclax induced greater apoptosis in ex vivo-cultured cll cells obtained from patients on duvelisib compared with pre-treatment cll cells from the same patients. |
2017-09-28 |
2023-08-13 |
Not clear |
| Yelisetti Uma Mahesh, Henderson Rose Winnie Gibence, Sisinthy Shivaji, Brahmasani Sambasiva Ra. Effect of different cryo-devices on in vitro maturation and development of vitrified-warmed immature buffalo oocytes. Cryobiology. vol 75. 2017-09-27. PMID:28093199. |
the expression of oocyte secreting factors and their receptors (gdf9, bmp15, bmpr2, tgfbr1) and apoptosis related genes (bcl2, bax, p53, c-myc) were compared in vitrified-warmed oocytes after in vitro maturation. |
2017-09-27 |
2023-08-13 |
Not clear |
| Florian Ebner, Vitaly Sedlyarov, Saren Tasciyan, Masa Ivin, Franz Kratochvill, Nina Gratz, Lukas Kenner, Andreas Villunger, Michael Sixt, Pavel Kovari. The RNA-binding protein tristetraprolin schedules apoptosis of pathogen-engaged neutrophils during bacterial infection. The Journal of clinical investigation. vol 127. issue 6. 2017-09-26. PMID:28504646. |
neutrophil transcriptome analysis revealed that decreased apoptosis of ttp-deficient neutrophils was specifically associated with elevated expression of myeloid cell leukemia 1 (mcl1) but not other antiapoptotic b cell leukemia/lymphoma 2 (bcl2) family members. |
2017-09-26 |
2023-08-13 |
mouse |
| Sudeshna Mukherjee, Sayan Ghosh, Dipesh Kr Das, Priyanka Chakraborty, Sreetama Choudhury, Payal Gupta, Arghya Adhikary, Sanjit Dey, Sreya Chattopadhya. Gold-conjugated green tea nanoparticles for enhanced anti-tumor activities and hepatoprotection--synthesis, characterization and in vitro evaluation. The Journal of nutritional biochemistry. vol 26. issue 11. 2017-09-25. PMID:26310506. |
these nps significantly decreased nuclear translocation of nf-κb, coupled with decreased phosphorylation of iĸb and down-regulation of nf-κb-dependent anti-apoptotic proteins bcl2 and akt in a dose-dependent manner, triggering onset of apoptosis. |
2017-09-25 |
2023-08-13 |
mouse |
| Qiong Wang, Yingjun She, Xiaobao Bi, Baisong Zhao, Xiangcai Ruan, Yonghong Ta. Dexmedetomidine Protects PC12 Cells from Lidocaine-Induced Cytotoxicity Through Downregulation of COL3A1 Mediated by miR-let-7b. DNA and cell biology. vol 36. issue 7. 2017-09-20. PMID:28436683. |
meanwhile, proteins involved in cell apoptosis, such as bcl2 and caspase 3, were impacted as well. |
2017-09-20 |
2023-08-13 |
Not clear |
| Meike Vogler, Harriet S Walter, Martin J S Dye. Targeting anti-apoptotic BCL2 family proteins in haematological malignancies - from pathogenesis to treatment. British journal of haematology. vol 178. issue 3. 2017-09-19. PMID:28449207. |
the b-cell lymphoma 2 (bcl2) family of proteins comprise key regulators of apoptosis and are implicated in the pathogenesis of many malignancies, including lymphomas and leukaemias. |
2017-09-19 |
2023-08-13 |
Not clear |
| Eugene Roscioli, Hai B Tran, Hubertus Jersmann, Phan T Nguyen, Emily Hopkins, Susan Lester, Nigel Farrow, Peter Zalewski, Paul N Reynolds, Sandra Hodg. The uncoupling of autophagy and zinc homeostasis in airway epithelial cells as a fundamental contributor to COPD. American journal of physiology. Lung cellular and molecular physiology. vol 313. issue 3. 2017-09-18. PMID:28596293. |
we applied a human ex vivo air-liquid interface model, a murine model of smoke exposure, and human lung tissues and investigated zn, zip1, and zip2 zn-influx proteins, autophagy [microtubule-associated 1a/1b-light chain-3 (lc3), beclin-1], autophagic flux (sequestosome), apoptosis [bcl2; x-linked inhibitor of apoptosis (xiap), poly (adp)-ribose polymerase (parp)], and inflammation [thymic stromal lymphopoietin (tslp), regulated on activation, normal t cell expressed and secreted (rantes), and il-1β]. |
2017-09-18 |
2023-08-13 |
mouse |