| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ulrike B Hendgen-Cotta, Sonja Esfeld, Katharina Rudi, Ilkka Miinalainen, Johann P Klare, Tienush Rassa. Cytosolic BNIP3 Dimer Interacts with Mitochondrial BAX Forming Heterodimers in the Mitochondrial Outer Membrane under Basal Conditions. International journal of molecular sciences. vol 18. issue 4. 2017-04-28. PMID:28333095. |
we investigated the basal distribution of cardiac bnip3 in vivo and its physical interaction with the pro-death protein bcl2 associated x, apoptosis regulator (bax) and with mitochondria using immunoblot analysis, co-immunoprecipitation, and continuous wave and pulsed electron paramagnetic resonance spectroscopy techniques. |
2017-04-28 |
2023-08-13 |
Not clear |
| Qi Jiang, Qingwei Li, Jianmei Han, Meng Gou, Yuanyuan Zheng, Bowen Li, Rong Xiao, Jihong Wan. rLj-RGD3 induces apoptosis via the mitochondrial-dependent pathway and inhibits adhesion, migration and invasion of human HeyA8 cells via FAK pathway. International journal of biological macromolecules. vol 96. 2017-04-17. PMID:28038913. |
according to the confocal microscope, flow cytometry and western blot analysis, rlj-rgd3 could trigger heya8 cells apoptosis by changing mitochondrial membrane potential, arrangement of f-actin, protein level of bcl2, bax, caspase 3, and cleaved caspase 3, concentration of cytoplasmic calcium, as well as phosphorylation level of erk/jnk/p38. |
2017-04-17 |
2023-08-13 |
human |
| Su-Jin Cho, Kyeong-Lim Lee, Yu-Gon Kim, Dong-Hoon Kim, Jae-Gyu Yoo, Byoung-Chul Yang, Jin-Ki Park, Il-Keun Kon. Differential gene-expression profiles from canine cumulus cells of ovulated versus in vitro-matured oocytes. Reproduction, fertility, and development. vol 28. issue 3. 2017-04-10. PMID:25004936. |
genes analysed are related to cell maturation, development and apoptosis, including gdf9, mapk1, ptx3, cx43, bcl2 and bax; mrna expression for all of these genes, except for gdf9, differed (p<0.05) between in vivo- and in vitro-matured ccs. |
2017-04-10 |
2023-08-13 |
Not clear |
| Guangxian Zhang, Xiancheng Zeng, Ren Zhang, Juan Liu, Weici Zhang, Yujun Zhao, Xiaoyuan Zhang, Zhixue Wu, Yuhui Tan, Yingya Wu, Biaoyan D. Dioscin suppresses hepatocellular carcinoma tumor growth by inducing apoptosis and regulation of TP53, BAX, BCL2 and cleaved CASP3. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 23. issue 12. 2017-04-07. PMID:27765352. |
dioscin suppresses hepatocellular carcinoma tumor growth by inducing apoptosis and regulation of tp53, bax, bcl2 and cleaved casp3. |
2017-04-07 |
2023-08-13 |
Not clear |
| Yan Li, Tao Yang, Jing Li, Hong-Ling Hao, Su-Yun Wang, Jie Yang, Jian-Min Lu. Inhibition of multiple myeloma cell proliferation by ginsenoside Rg3 via reduction in the secretion of IGF-1. Molecular medicine reports. vol 14. issue 3. 2017-04-06. PMID:27430248. |
furthermore, rg3 induced multiple myeloma cell apoptosis, and was involved in b cell lymphoma-2 (bcl2)/bcl2-associated x protein imbalance, caspase activation and the release of cytochrome c from the mitochondria into the cytoplasm. |
2017-04-06 |
2023-08-13 |
human |
| Tao Lin, Jae Eun Lee, Reza K Oqani, So Yeon Kim, Eun Seok Cho, Yong Dae Jeong, Jun Jong Baek, Dong Il Ji. Tauroursodeoxycholic acid improves pre-implantation development of porcine SCNT embryo by endoplasmic reticulum stress inhibition. Reproductive biology. vol 16. issue 4. 2017-04-06. PMID:27765486. |
tunel assay showed that tudca treatment significantly reduced apoptosis in porcine scnt blastocysts confirmed by decreased pro-apoptotic bax and increased anti-apoptotic bcl2 mrna levels. |
2017-04-06 |
2023-08-13 |
Not clear |
| Nerea Rebolleda, Ignacio Losada-Fernandez, Gema Perez-Chacon, Raquel Castejon, Silvia Rosado, Marta Morado, Maria Teresa Vallejo-Cremades, Andrea Martinez, Juan A Vargas-Nuñez, Paloma Perez-Acieg. Synergistic Activity of Deguelin and Fludarabine in Cells from Chronic Lymphocytic Leukemia Patients and in the New Zealand Black Murine Model. PloS one. vol 11. issue 4. 2017-04-05. PMID:27101369. |
in both of them, deguelin dowregulates akt, nfκb and several downstream antiapoptotic proteins (xiap, ciap, bcl2, bcl-xl and survivin), activating the mitochondrial pathway of apoptosis. |
2017-04-05 |
2023-08-13 |
mouse |
| Maryam Jalayeri, Afshin Pirnia, Elaheh Poorazizi Najafabad, Ali Mohammad Varzi, Mohammadreza Gholam. Evaluation of alginate hydrogel cytotoxicity on three-dimensional culture of type A spermatogonial stem cells. International journal of biological macromolecules. vol 95. 2017-04-05. PMID:27984148. |
after one month of encapsulation and culture in dmem culture medium containing 10ng/ml gdnf, cells were removed from hydrogel and were examined for viability, cell morphology and structure, cytotoxicity and expression of apoptosis genes fas, p53, bax, bcl2, caspase3 by staining with trypan blue, scanning electron microscopy, ldh test, and real time pcr, respectively. |
2017-04-05 |
2023-08-13 |
mouse |
| Magdalena Dziegala, Monika Kasztura, Kamil Kobak, Jacek Bania, Waldemar Banasiak, Piotr Ponikowski, Ewa A Jankowsk. Influence of the availability of iron during hypoxia on the genes associated with apoptotic activity and local iron metabolism in rat H9C2 cardiomyocytes and L6G8C5 skeletal myocytes. Molecular medicine reports. vol 14. issue 4. 2017-04-04. PMID:27599775. |
the mrna expression levels of markers of apoptosis [b‑cell lymphoma‑2 (bcl2; inhibition) and bcl‑2‑activated x protein (bax; induction)], atrophy (atrogin), glycolysis (pyruvate kinase 2; pkm2) and iron metabolism [transferrin receptor 1 (tfr1; iron importer), ferroportin 1 (fpn1; iron exporter), ferritin heavy chain (fth; iron storage protein) and hepcidin (hamp; iron regulator)] were determined using reverse transcription‑quantitative polymerase chain reaction, and cell viability was measured using an tetrazolium reduction assay. |
2017-04-04 |
2023-08-13 |
rat |
| Yu Lei, Bo Zhang, Yaohua Zhang, Yuan Zhao, Jingying Sun, Xuejun Zhang, Sen Yan. Lentivirus-mediated downregulation of MAT2B inhibits cell proliferation and induces apoptosis in melanoma. International journal of oncology. vol 49. issue 3. 2017-04-03. PMID:27573889. |
the expression levels of bcl2 and xaf1 proteins, which were closely related to tumor cell apoptosis, were analyzed by western blot analysis. |
2017-04-03 |
2023-08-13 |
Not clear |
| Yu Lei, Bo Zhang, Yaohua Zhang, Yuan Zhao, Jingying Sun, Xuejun Zhang, Sen Yan. Lentivirus-mediated downregulation of MAT2B inhibits cell proliferation and induces apoptosis in melanoma. International journal of oncology. vol 49. issue 3. 2017-04-03. PMID:27573889. |
lentivirus-mediated downregulation of mat2b suppressed cell growth, colony formation and induced apoptosis in a375 and mel-rm cell lines in vitro, affected protein expression of bcl2 and xaf1, extended the transplanted tumor growth in vivo. |
2017-04-03 |
2023-08-13 |
Not clear |
| Chen Yang, Xiaojuan Liu, Fangfang Yang, Weixun Zhang, Zihao Chen, Daliang Yan, Qingsheng You, Xiang W. Mitochondrial phosphatase PGAM5 regulates Keap1-mediated Bcl-xL degradation and controls cardiomyocyte apoptosis driven by myocardial ischemia/reperfusion injury. In vitro cellular & developmental biology. Animal. vol 53. issue 3. 2017-03-30. PMID:27815660. |
though pgam5 is known to be required for inducing intrinsic apoptosis through interacting with bcl2 associated x protein (bax) and dynamin-related protein 1 (drp1), the expression and role of pgam5 in cardiomyocyte apoptosis driven by myocardial ischemia/reperfusion injury(miri) has not been studied. |
2017-03-30 |
2023-08-13 |
Not clear |
| Ebrahim Hosseini, Seyed Younes Hosseini, Tayebeh Hashempour, Mohammad-Reza Fattahi, Majid Sadeghizade. Effect of RGD coupled MDA-7/IL-24 on apoptosis induction in a hepatocellular carcinoma cell line. Molecular medicine reports. vol 15. issue 1. 2017-03-30. PMID:27959433. |
the expression level of the pro‑apoptotic dna damage inducible transcript 3 (gadd153) and bcl2 associated x apoptosis regulator (bax) genes in the different groups were compared by reverse transcription-quantitative polymerase chain reaction. |
2017-03-30 |
2023-08-13 |
Not clear |
| Manel Boussabbeh, Intidhar Ben Salem, Faicel Belguesmi, Fadwa Neffati, Mohamed Fadhel Najjar, Salwa Abid-Essefi, Hassen Bach. Crocin protects the liver and kidney from patulin-induced apoptosis in vivo. Environmental science and pollution research international. vol 23. issue 10. 2017-03-23. PMID:26856859. |
the analysis of the protein expression in these organs revealed that pat-induced toxicity promotes the induction of apoptosis via the increase in p53, bax, and cytochrome c and the decrease in bcl2 expressions. |
2017-03-23 |
2023-08-13 |
mouse |
| Ho-Chen Lin, Chin-Lin Huang, Yuh-Jeen Huang, I-Lun Hsiao, Chung-Wei Yang, Chun-Yu Chuan. Transcriptomic gene-network analysis of exposure to silver nanoparticle reveals potentially neurodegenerative progression in mouse brain neural cells. Toxicology in vitro : an international journal published in association with BIBRA. vol 34. 2017-03-23. PMID:27131904. |
in focal adhesion pathway of alt astrocytes, agnps induced the gene expression of rasgrf1 and reduced its downstream bcl2 gene for apoptosis. |
2017-03-23 |
2023-08-13 |
mouse |
| b' Matja\\xc5\\xbe Novak, Bojana \\xc5\\xbdegura, \\xc5\\xa0pela Baebler, Alja \\xc5\\xa0tern, Ana Rotter, Katja Stare, Metka Filipi\\xc4\\x8. Influence of selected anti-cancer drugs on the induction of DNA double-strand breaks and changes in gene expression in human hepatoma HepG2 cells. Environmental science and pollution research international. vol 23. issue 15. 2017-03-21. PMID:26392091.' |
the analysis of the changes in the expression of genes involved in the response to dna damage (cdkn1a, gadd45a, mdm2), apoptosis (bax, bcl2) and oncogenesis (myc, jun) showed that 5-fu, cddp and et upregulated the genes involved in dna damage response, while the anti-apoptotic gene bcl2 and oncogene myc were downregulated. |
2017-03-21 |
2023-08-13 |
human |
| Naoya Inoue, Mikio Watanabe, Naoko Ishido, Arisa Kodu, Hayato Maruoka, Yuka Katsumata, Yoh Hidaka, Yoshinori Iwatan. Involvement of genes encoding apoptosis regulatory factors (FAS, FASL, TRAIL, BCL2, TNFR1 and TNFR2) in the pathogenesis of autoimmune thyroid diseases. Human immunology. vol 77. issue 10. 2017-03-15. PMID:27458112. |
involvement of genes encoding apoptosis regulatory factors (fas, fasl, trail, bcl2, tnfr1 and tnfr2) in the pathogenesis of autoimmune thyroid diseases. |
2017-03-15 |
2023-08-13 |
human |
| Naoya Inoue, Mikio Watanabe, Naoko Ishido, Arisa Kodu, Hayato Maruoka, Yuka Katsumata, Yoh Hidaka, Yoshinori Iwatan. Involvement of genes encoding apoptosis regulatory factors (FAS, FASL, TRAIL, BCL2, TNFR1 and TNFR2) in the pathogenesis of autoimmune thyroid diseases. Human immunology. vol 77. issue 10. 2017-03-15. PMID:27458112. |
to clarify the association between the pathogenesis of autoimmune thyroid disease (aitd) and genes encoding apoptosis regulatory factors, we genotyped the fas -1377g/a, -670a/g, fasl -844c/t, trail -716c/t, bcl2 -938c/a, +127g/a, tnfr1 -383a/c and tnfr2 +676t/g polymorphisms. |
2017-03-15 |
2023-08-13 |
human |
| Naoya Inoue, Mikio Watanabe, Naoko Ishido, Arisa Kodu, Hayato Maruoka, Yuka Katsumata, Yoh Hidaka, Yoshinori Iwatan. Involvement of genes encoding apoptosis regulatory factors (FAS, FASL, TRAIL, BCL2, TNFR1 and TNFR2) in the pathogenesis of autoimmune thyroid diseases. Human immunology. vol 77. issue 10. 2017-03-15. PMID:27458112. |
the polymorphisms in genes encoding apoptosis regulatory factors (fasl, bcl2) and serum levels of sfasl may be associated with immune dysregulation. |
2017-03-15 |
2023-08-13 |
human |
| Maoxi Liu, Zhongxue Fu, Xingye Wu, Kunli Du, Shouru Zhang, Li Zen. Inhibition of phospholipaseD2 increases hypoxia-induced human colon cancer cell apoptosis through inactivating of the PI3K/AKT signaling pathway. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 5. 2017-03-10. PMID:26614430. |
however, inhibition the activity of pld2 induced by hypoxia promotes the apoptosis of human colon cancer cells, as well as decreased the expression of apoptosis markers including survivin and bcl2. |
2017-03-10 |
2023-08-13 |
human |