| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eugene Roscioli, Hai B Tran, Hubertus Jersmann, Phan T Nguyen, Emily Hopkins, Susan Lester, Nigel Farrow, Peter Zalewski, Paul N Reynolds, Sandra Hodg. The uncoupling of autophagy and zinc homeostasis in airway epithelial cells as a fundamental contributor to COPD. American journal of physiology. Lung cellular and molecular physiology. vol 313. issue 3. 2017-09-18. PMID:28596293. |
we applied a human ex vivo air-liquid interface model, a murine model of smoke exposure, and human lung tissues and investigated zn, zip1, and zip2 zn-influx proteins, autophagy [microtubule-associated 1a/1b-light chain-3 (lc3), beclin-1], autophagic flux (sequestosome), apoptosis [bcl2; x-linked inhibitor of apoptosis (xiap), poly (adp)-ribose polymerase (parp)], and inflammation [thymic stromal lymphopoietin (tslp), regulated on activation, normal t cell expressed and secreted (rantes), and il-1β]. |
2017-09-18 |
2023-08-13 |
mouse |
| Eugene Roscioli, Hai B Tran, Hubertus Jersmann, Phan T Nguyen, Emily Hopkins, Susan Lester, Nigel Farrow, Peter Zalewski, Paul N Reynolds, Sandra Hodg. The uncoupling of autophagy and zinc homeostasis in airway epithelial cells as a fundamental contributor to COPD. American journal of physiology. Lung cellular and molecular physiology. vol 313. issue 3. 2017-09-18. PMID:28596293. |
autophagic dysfunction due to cs exposure coupled with zn depletion also induced apoptosis, with the reduction of antiapoptotic and antiautophagic proteins bcl2 and xiap and parp cleavage. |
2017-09-18 |
2023-08-13 |
mouse |
| Ping Yang, Fulu Dong, Quansheng Zho. Triptonide acts as a novel potent anti-lymphoma agent with low toxicity mainly through inhibition of proto-oncogene Lyn transcription and suppression of Lyn signal pathway. Toxicology letters. vol 278. 2017-08-21. PMID:28666825. |
cell biological studies showed that triptonide at the doses of 2.5-10nm notably suppressed b-lymphoma cell colony-forming capability, and that triptonide at the dose of 20nm promoted apoptosis through activation of parp and caspase 3, but reduction of bcl2 protein levels in the lymphoma cells. |
2017-08-21 |
2023-08-13 |
mouse |
| Michał Szewczuk, Karolina Boguszewska, Marta Żebrowska, Ewa Balcerczak, Marta Stasiak, Maria Świątkowska, Katarzyna Błaszczak-Świątkiewic. Virus-directed enzyme prodrug therapy and the assessment of the cytotoxic impact of some benzimidazole derivatives. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 39. issue 7. 2017-08-15. PMID:28752801. |
the apoptosis was confirmed by generation of bax gene and protein and reduction of bcl2 gene and protein. |
2017-08-15 |
2023-08-13 |
Not clear |
| Charlotte Viant, Sophie Guia, Robert J Hennessy, Jai Rautela, Kim Pham, Claire Bernat, Wilford Goh, Yuhao Jiao, Rebecca Delconte, Michael Roger, Vanina Simon, Fernando Souza-Fonseca-Guimaraes, Stephanie Grabow, Gabrielle T Belz, Benjamin T Kile, Andreas Strasser, Daniel Gray, Phillip D Hodgkin, Bruce Beutler, Eric Vivier, Sophie Ugolini, Nicholas D Huntingto. Cell cycle progression dictates the requirement for BCL2 in natural killer cell survival. The Journal of experimental medicine. vol 214. issue 2. 2017-08-14. PMID:28057804. |
in these mice, nk cells in cycle were protected against apoptosis, and nk cell counts were restored in inflammatory conditions, suggesting a redundant role for bcl2 in proliferating nk cells. |
2017-08-14 |
2023-08-13 |
mouse |
| Xinzheng Jia, Hongjia Ouyang, Bahareldin Ali Abdalla, Haiping Xu, Qinghua Nie, Xiquan Zhan. miR-16 controls myoblast proliferation and apoptosis through directly suppressing Bcl2 and FOXO1 activities. Biochimica et biophysica acta. Gene regulatory mechanisms. vol 1860. issue 6. 2017-08-14. PMID:28258011. |
mir-16 controls myoblast proliferation and apoptosis through directly suppressing bcl2 and foxo1 activities. |
2017-08-14 |
2023-08-13 |
chicken |
| Xinzheng Jia, Hongjia Ouyang, Bahareldin Ali Abdalla, Haiping Xu, Qinghua Nie, Xiquan Zhan. miR-16 controls myoblast proliferation and apoptosis through directly suppressing Bcl2 and FOXO1 activities. Biochimica et biophysica acta. Gene regulatory mechanisms. vol 1860. issue 6. 2017-08-14. PMID:28258011. |
here, we reported that mir-16 inhibited myoblast proliferation and promoted myoblast apoptosis by directly targeting bcl2 and foxo1. |
2017-08-14 |
2023-08-13 |
chicken |
| Xinzheng Jia, Hongjia Ouyang, Bahareldin Ali Abdalla, Haiping Xu, Qinghua Nie, Xiquan Zhan. miR-16 controls myoblast proliferation and apoptosis through directly suppressing Bcl2 and FOXO1 activities. Biochimica et biophysica acta. Gene regulatory mechanisms. vol 1860. issue 6. 2017-08-14. PMID:28258011. |
consist to the effect of mir-16 on myogenesis, specific inhibition of bcl2 or foxo1 significantly suppressed myoblast proliferation and induced myoblast apoptosis, indicating that both bcl2 and foxo1 contributed to mir-16 regulatory function in myogenesis. |
2017-08-14 |
2023-08-13 |
chicken |
| Annalisa Conti, Maria Teresa Majorini, Enrico Fontanella, Alberto Bardelli, Mauro Giacca, Domenico Delia, Miguel Mano, Daniele Leci. Lemur tyrosine kinase 2 (LMTK2) is a determinant of cell sensitivity to apoptosis by regulating the levels of the BCL2 family members. Cancer letters. vol 389. 2017-08-08. PMID:28040547. |
lemur tyrosine kinase 2 (lmtk2) is a determinant of cell sensitivity to apoptosis by regulating the levels of the bcl2 family members. |
2017-08-08 |
2023-08-13 |
Not clear |
| Marta Czernik, Paola Toschi, Federica Zacchini, Domenico Iuso, Grażyna Ewa Pta. Deregulated Expression of Mitochondrial Proteins Mfn2 and Bcnl3L in Placentae from Sheep Somatic Cell Nuclear Transfer (SCNT) Conceptuses. PloS one. vol 12. issue 1. 2017-08-03. PMID:28076382. |
likely, this accumulation of damaged organelles led to uncontrolled apoptosis in scnt placentae, as demonstrated by the high number of apoptotic bodies, fragmented cytoplasm, condensed chromatin, lack of integrity of the nuclear membrane and the perturbed mrna expression of apoptotic genes (bcl2 and bax). |
2017-08-03 |
2023-08-13 |
Not clear |
| Mary Ann Anderson, Jing Deng, John F Seymour, Constantine Tam, Su Young Kim, Joshua Fein, Lijian Yu, Jennifer R Brown, David Westerman, Eric G Si, Ian J Majewski, David Segal, Sari L Heitner Enschede, David C S Huang, Matthew S Davids, Anthony Letai, Andrew W Robert. The BCL2 selective inhibitor venetoclax induces rapid onset apoptosis of CLL cells in patients via a TP53-independent mechanism. Blood. vol 127. issue 25. 2017-08-02. PMID:27069256. |
the bcl2 selective inhibitor venetoclax induces rapid onset apoptosis of cll cells in patients via a tp53-independent mechanism. |
2017-08-02 |
2023-08-13 |
Not clear |
| Mary Ann Anderson, Jing Deng, John F Seymour, Constantine Tam, Su Young Kim, Joshua Fein, Lijian Yu, Jennifer R Brown, David Westerman, Eric G Si, Ian J Majewski, David Segal, Sari L Heitner Enschede, David C S Huang, Matthew S Davids, Anthony Letai, Andrew W Robert. The BCL2 selective inhibitor venetoclax induces rapid onset apoptosis of CLL cells in patients via a TP53-independent mechanism. Blood. vol 127. issue 25. 2017-08-02. PMID:27069256. |
bcl2 blunts activation of the mitochondrial pathway to apoptosis, and high-level expression is required for chronic lymphocytic leukemia (cll) survival. |
2017-08-02 |
2023-08-13 |
Not clear |
| Xin Cao, Ying Lu, Xianyu Zhang, Damian Kovalovsk. Zbtb1 Safeguards Genome Integrity and Prevents p53-Mediated Apoptosis in Proliferating Lymphoid Progenitors. Journal of immunology (Baltimore, Md. : 1950). vol 197. issue 4. 2017-08-02. PMID:27402700. |
increased p53-mediated apoptosis affected not only lymphoid but also myeloid development in competitive bone marrow chimeras, and prevention of apoptosis by transgenic bcl2 expression and p53 deficiency rescued lymphoid as well as myeloid development from zbtb1-mutant progenitors. |
2017-08-02 |
2023-08-13 |
Not clear |
| Tahereh Javaheri, Zahra Kazemi, Jan Pencik, Ha Tt Pham, Maximilian Kauer, Rahil Noorizadeh, Barbara Sax, Harini Nivarthi, Michaela Schlederer, Barbara Maurer, Maximillian Hofbauer, Dave Nt Aryee, Marc Wiedner, Eleni M Tomazou, Malcolm Logan, Christine Hartmann, Jan P Tuckermann, Lukas Kenner, Mario Mikula, Helmut Dolznig, Aykut Üren, Günther H Richter, Florian Grebien, Heinrich Kovar, Richard Morigg. Increased survival and cell cycle progression pathways are required for EWS/FLI1-induced malignant transformation. Cell death & disease. vol 7. issue 10. 2017-07-31. PMID:27735950. |
blocking apoptosis through enforced bcl2 family member expression in mscs promoted efficient and rapid sarcoma formation when transplanted to immunocompromised mice. |
2017-07-31 |
2023-08-13 |
mouse |
| Fara Brasó-Maristany, Simone Filosto, Steven Catchpole, Rebecca Marlow, Jelmar Quist, Erika Francesch-Domenech, Darren A Plumb, Leila Zakka, Patrycja Gazinska, Gianmaria Liccardi, Pascal Meier, Albert Gris-Oliver, Maggie Chon U Cheang, Anna Perdrix-Rosell, Manar Shafat, Elodie Noël, Nirmesh Patel, Kristen McEachern, Maurizio Scaltriti, Pau Castel, Farzana Noor, Richard Buus, Sumi Mathew, Johnathan Watkins, Violeta Serra, Pierfrancesco Marra, Anita Grigoriadis, Andrew N Tut. PIM1 kinase regulates cell death, tumor growth and chemotherapy response in triple-negative breast cancer. Nature medicine. vol 22. issue 11. 2017-07-31. PMID:27775704. |
pim1 knockdown reduced expression of the anti-apoptotic factor bcl2, and dynamic bh3 profiling of apoptotic priming revealed that pim1 prevents mitochondrial-mediated apoptosis in tnbc cell lines. |
2017-07-31 |
2023-08-13 |
Not clear |
| Viswanath Gunda, Kristopher A Sarosiek, Eran Brauner, Yon Seon Kim, Salma Amin, Zhiheng Zhou, Antony Letai, Sareh Parang. Inhibition of MAPKinase pathway sensitizes thyroid cancer cells to ABT-737 induced apoptosis. Cancer letters. vol 395. 2017-07-31. PMID:28259821. |
bcl2 family proteins play an important role in the resistance of thyroid cancer cells to apoptosis induced by chemotherapeutic drugs and targeted therapies. |
2017-07-31 |
2023-08-13 |
mouse |
| Viswanath Gunda, Kristopher A Sarosiek, Eran Brauner, Yon Seon Kim, Salma Amin, Zhiheng Zhou, Antony Letai, Sareh Parang. Inhibition of MAPKinase pathway sensitizes thyroid cancer cells to ABT-737 induced apoptosis. Cancer letters. vol 395. 2017-07-31. PMID:28259821. |
targeting bcl2 family proteins with the bh3 mimetic, abt-737, while simultaneously inhibiting erk pathway proteins with plx4720 and pd325901 was shown to induce significantly high apoptosis in the majority of cell lines (8505c, sw1736, hth7, bcpap) and moderate apoptosis in the tpc-1 cell line. |
2017-07-31 |
2023-08-13 |
mouse |
| Akinori Kawakami, David E Fishe. The master role of microphthalmia-associated transcription factor in melanocyte and melanoma biology. Laboratory investigation; a journal of technical methods and pathology. vol 97. issue 6. 2017-07-27. PMID:28263292. |
mitf regulates expression of numerous pigmentation genes to promote melanocyte differentiation, as well as fundamental genes for maintaining cell homeostasis, including genes encoding proteins involved in apoptosis (eg, bcl2) and the cell cycle (eg, cdk2). |
2017-07-27 |
2023-08-13 |
Not clear |
| Boon Chin Heng, Xin Ye, Yuan Liu, Waruna Lakmal Dissanayaka, Gary Shun Pan Cheung, Chengfei Zhan. Effects of Recombinant Overexpression of Bcl2 on the Proliferation, Apoptosis, and Osteogenic/Odontogenic Differentiation Potential of Dental Pulp Stem Cells. Journal of endodontics. vol 42. issue 4. 2017-07-26. PMID:26898562. |
effects of recombinant overexpression of bcl2 on the proliferation, apoptosis, and osteogenic/odontogenic differentiation potential of dental pulp stem cells. |
2017-07-26 |
2023-08-13 |
Not clear |
| Z Xu, P P Sharp, Y Yao, D Segal, C H Ang, S L Khaw, B J Aubrey, J Gong, G L Kelly, M J Herold, A Strasser, A W Roberts, W S Alexander, C J Burns, D C S Huang, S P Glase. BET inhibition represses miR17-92 to drive BIM-initiated apoptosis of normal and transformed hematopoietic cells. Leukemia. vol 30. issue 7. 2017-07-26. PMID:27055867. |
thus, our study strongly suggests that mutations that permit the evasion of apoptosis (for example, bcl2 overexpression, bim inactivation) are likely to blunt the activity of the bet bromodomain inhibitors and should be anticipated when therapy resistance develops. |
2017-07-26 |
2023-08-13 |
mouse |