| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Magdalena Dziegala, Monika Kasztura, Kamil Kobak, Jacek Bania, Waldemar Banasiak, Piotr Ponikowski, Ewa A Jankowsk. Influence of the availability of iron during hypoxia on the genes associated with apoptotic activity and local iron metabolism in rat H9C2 cardiomyocytes and L6G8C5 skeletal myocytes. Molecular medicine reports. vol 14. issue 4. 2017-04-04. PMID:27599775. |
the mrna expression levels of markers of apoptosis [b‑cell lymphoma‑2 (bcl2; inhibition) and bcl‑2‑activated x protein (bax; induction)], atrophy (atrogin), glycolysis (pyruvate kinase 2; pkm2) and iron metabolism [transferrin receptor 1 (tfr1; iron importer), ferroportin 1 (fpn1; iron exporter), ferritin heavy chain (fth; iron storage protein) and hepcidin (hamp; iron regulator)] were determined using reverse transcription‑quantitative polymerase chain reaction, and cell viability was measured using an tetrazolium reduction assay. |
2017-04-04 |
2023-08-13 |
rat |
| Yu Lei, Bo Zhang, Yaohua Zhang, Yuan Zhao, Jingying Sun, Xuejun Zhang, Sen Yan. Lentivirus-mediated downregulation of MAT2B inhibits cell proliferation and induces apoptosis in melanoma. International journal of oncology. vol 49. issue 3. 2017-04-03. PMID:27573889. |
the expression levels of bcl2 and xaf1 proteins, which were closely related to tumor cell apoptosis, were analyzed by western blot analysis. |
2017-04-03 |
2023-08-13 |
Not clear |
| Yu Lei, Bo Zhang, Yaohua Zhang, Yuan Zhao, Jingying Sun, Xuejun Zhang, Sen Yan. Lentivirus-mediated downregulation of MAT2B inhibits cell proliferation and induces apoptosis in melanoma. International journal of oncology. vol 49. issue 3. 2017-04-03. PMID:27573889. |
lentivirus-mediated downregulation of mat2b suppressed cell growth, colony formation and induced apoptosis in a375 and mel-rm cell lines in vitro, affected protein expression of bcl2 and xaf1, extended the transplanted tumor growth in vivo. |
2017-04-03 |
2023-08-13 |
Not clear |
| Chen Yang, Xiaojuan Liu, Fangfang Yang, Weixun Zhang, Zihao Chen, Daliang Yan, Qingsheng You, Xiang W. Mitochondrial phosphatase PGAM5 regulates Keap1-mediated Bcl-xL degradation and controls cardiomyocyte apoptosis driven by myocardial ischemia/reperfusion injury. In vitro cellular & developmental biology. Animal. vol 53. issue 3. 2017-03-30. PMID:27815660. |
though pgam5 is known to be required for inducing intrinsic apoptosis through interacting with bcl2 associated x protein (bax) and dynamin-related protein 1 (drp1), the expression and role of pgam5 in cardiomyocyte apoptosis driven by myocardial ischemia/reperfusion injury(miri) has not been studied. |
2017-03-30 |
2023-08-13 |
Not clear |
| Ebrahim Hosseini, Seyed Younes Hosseini, Tayebeh Hashempour, Mohammad-Reza Fattahi, Majid Sadeghizade. Effect of RGD coupled MDA-7/IL-24 on apoptosis induction in a hepatocellular carcinoma cell line. Molecular medicine reports. vol 15. issue 1. 2017-03-30. PMID:27959433. |
the expression level of the pro‑apoptotic dna damage inducible transcript 3 (gadd153) and bcl2 associated x apoptosis regulator (bax) genes in the different groups were compared by reverse transcription-quantitative polymerase chain reaction. |
2017-03-30 |
2023-08-13 |
Not clear |
| Manel Boussabbeh, Intidhar Ben Salem, Faicel Belguesmi, Fadwa Neffati, Mohamed Fadhel Najjar, Salwa Abid-Essefi, Hassen Bach. Crocin protects the liver and kidney from patulin-induced apoptosis in vivo. Environmental science and pollution research international. vol 23. issue 10. 2017-03-23. PMID:26856859. |
the analysis of the protein expression in these organs revealed that pat-induced toxicity promotes the induction of apoptosis via the increase in p53, bax, and cytochrome c and the decrease in bcl2 expressions. |
2017-03-23 |
2023-08-13 |
mouse |
| Ho-Chen Lin, Chin-Lin Huang, Yuh-Jeen Huang, I-Lun Hsiao, Chung-Wei Yang, Chun-Yu Chuan. Transcriptomic gene-network analysis of exposure to silver nanoparticle reveals potentially neurodegenerative progression in mouse brain neural cells. Toxicology in vitro : an international journal published in association with BIBRA. vol 34. 2017-03-23. PMID:27131904. |
in focal adhesion pathway of alt astrocytes, agnps induced the gene expression of rasgrf1 and reduced its downstream bcl2 gene for apoptosis. |
2017-03-23 |
2023-08-13 |
mouse |
| b' Matja\\xc5\\xbe Novak, Bojana \\xc5\\xbdegura, \\xc5\\xa0pela Baebler, Alja \\xc5\\xa0tern, Ana Rotter, Katja Stare, Metka Filipi\\xc4\\x8. Influence of selected anti-cancer drugs on the induction of DNA double-strand breaks and changes in gene expression in human hepatoma HepG2 cells. Environmental science and pollution research international. vol 23. issue 15. 2017-03-21. PMID:26392091.' |
the analysis of the changes in the expression of genes involved in the response to dna damage (cdkn1a, gadd45a, mdm2), apoptosis (bax, bcl2) and oncogenesis (myc, jun) showed that 5-fu, cddp and et upregulated the genes involved in dna damage response, while the anti-apoptotic gene bcl2 and oncogene myc were downregulated. |
2017-03-21 |
2023-08-13 |
human |
| Naoya Inoue, Mikio Watanabe, Naoko Ishido, Arisa Kodu, Hayato Maruoka, Yuka Katsumata, Yoh Hidaka, Yoshinori Iwatan. Involvement of genes encoding apoptosis regulatory factors (FAS, FASL, TRAIL, BCL2, TNFR1 and TNFR2) in the pathogenesis of autoimmune thyroid diseases. Human immunology. vol 77. issue 10. 2017-03-15. PMID:27458112. |
involvement of genes encoding apoptosis regulatory factors (fas, fasl, trail, bcl2, tnfr1 and tnfr2) in the pathogenesis of autoimmune thyroid diseases. |
2017-03-15 |
2023-08-13 |
human |
| Naoya Inoue, Mikio Watanabe, Naoko Ishido, Arisa Kodu, Hayato Maruoka, Yuka Katsumata, Yoh Hidaka, Yoshinori Iwatan. Involvement of genes encoding apoptosis regulatory factors (FAS, FASL, TRAIL, BCL2, TNFR1 and TNFR2) in the pathogenesis of autoimmune thyroid diseases. Human immunology. vol 77. issue 10. 2017-03-15. PMID:27458112. |
to clarify the association between the pathogenesis of autoimmune thyroid disease (aitd) and genes encoding apoptosis regulatory factors, we genotyped the fas -1377g/a, -670a/g, fasl -844c/t, trail -716c/t, bcl2 -938c/a, +127g/a, tnfr1 -383a/c and tnfr2 +676t/g polymorphisms. |
2017-03-15 |
2023-08-13 |
human |
| Naoya Inoue, Mikio Watanabe, Naoko Ishido, Arisa Kodu, Hayato Maruoka, Yuka Katsumata, Yoh Hidaka, Yoshinori Iwatan. Involvement of genes encoding apoptosis regulatory factors (FAS, FASL, TRAIL, BCL2, TNFR1 and TNFR2) in the pathogenesis of autoimmune thyroid diseases. Human immunology. vol 77. issue 10. 2017-03-15. PMID:27458112. |
the polymorphisms in genes encoding apoptosis regulatory factors (fasl, bcl2) and serum levels of sfasl may be associated with immune dysregulation. |
2017-03-15 |
2023-08-13 |
human |
| Maoxi Liu, Zhongxue Fu, Xingye Wu, Kunli Du, Shouru Zhang, Li Zen. Inhibition of phospholipaseD2 increases hypoxia-induced human colon cancer cell apoptosis through inactivating of the PI3K/AKT signaling pathway. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 5. 2017-03-10. PMID:26614430. |
however, inhibition the activity of pld2 induced by hypoxia promotes the apoptosis of human colon cancer cells, as well as decreased the expression of apoptosis markers including survivin and bcl2. |
2017-03-10 |
2023-08-13 |
human |
| Maoxi Liu, Zhongxue Fu, Xingye Wu, Kunli Du, Shouru Zhang, Li Zen. Inhibition of phospholipaseD2 increases hypoxia-induced human colon cancer cell apoptosis through inactivating of the PI3K/AKT signaling pathway. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 5. 2017-03-10. PMID:26614430. |
furthermore, interference the pld2 gene expression leaded to the apoptosis of hypoxic colon cancer cells increased and also decreased the expression level of survivin and bcl2 may through inactivation of pi3k/akt signaling pathway. |
2017-03-10 |
2023-08-13 |
human |
| Wuhao Lu, Long Feng, Yan Zhang, Yunyun Ma, Ping Li, Yuanyuan Wang, Yuwen Du, Xiaonan Chen, Shujun Wu, Guoqiang Zhao, Weihua Lo. miR-15a induces cell apoptosis by targeting BCL2L2 and BCL2 in HPV-positive hypopharyngeal squamous cell carcinoma. Oncology reports. vol 36. issue 4. 2017-03-10. PMID:27573302. |
mir-15a induces cell apoptosis by targeting bcl2l2 and bcl2 in hpv-positive hypopharyngeal squamous cell carcinoma. |
2017-03-10 |
2023-08-13 |
Not clear |
| Wuhao Lu, Long Feng, Yan Zhang, Yunyun Ma, Ping Li, Yuanyuan Wang, Yuwen Du, Xiaonan Chen, Shujun Wu, Guoqiang Zhao, Weihua Lo. miR-15a induces cell apoptosis by targeting BCL2L2 and BCL2 in HPV-positive hypopharyngeal squamous cell carcinoma. Oncology reports. vol 36. issue 4. 2017-03-10. PMID:27573302. |
after transfection, overexpression of mir-15a in the fadu cells was associated with significantly decreased bcl2l2 and bcl2 expression and a significant increase in the apoptosis rate. |
2017-03-10 |
2023-08-13 |
Not clear |
| Cristiane Oliveira, Gustavo Jacob Lourenço, José Augusto Rinck-Junior, Aparecida Machado de Moraes, Carmen Silvia Passos Lim. Polymorphisms in apoptosis-related genes in cutaneous melanoma prognosis: sex disparity. Medical oncology (Northwood, London, England). vol 34. issue 2. 2017-03-08. PMID:28050764. |
cutaneous melanoma (cm) cells are resistant to apoptosis, and steroid hormones are involved in this process through regulation of tp53, mdm2, bax, and bcl2 expression. |
2017-03-08 |
2023-08-13 |
Not clear |
| Cristiane Oliveira, Gustavo Jacob Lourenço, José Augusto Rinck-Junior, Aparecida Machado de Moraes, Carmen Silvia Passos Lim. Polymorphisms in apoptosis-related genes in cutaneous melanoma prognosis: sex disparity. Medical oncology (Northwood, London, England). vol 34. issue 2. 2017-03-08. PMID:28050764. |
our data present, for the first time, preliminary evidence that inherited abnormalities on tp53, mdm2 and bcl2 genes, enrolled in apoptosis pathways, have a pivotal role in differences of outcomes in women and men with cm. |
2017-03-08 |
2023-08-13 |
Not clear |
| Wei Lu, Shu Ya Huang, Le Su, Bao Xiang Zhao, Jun Ying Mia. Long Noncoding RNA LOC100129973 Suppresses Apoptosis by Targeting miR-4707-5p and miR-4767 in Vascular Endothelial Cells. Scientific reports. vol 6. 2017-03-02. PMID:26887505. |
through sponging mir-4707-5p and mir-4767, lncrna loc100129973 upregulated the expression of two apoptosis repressors gene, apoptosis inhibitor 5 (api5) and bcl2 like 12 (bcl2l12), and thus alleviated the serum and fgf-2 starvation-induced apoptosis in vecs. |
2017-03-02 |
2023-08-13 |
Not clear |
| Moudan Lin, Tian Wu, Lingbin Sun, Jackie Jin Lin, Zhenghong Zuo, Chonggang Wan. Aroclor 1254 causes atrophy of exocrine pancreas in mice and the mechanism involved. Environmental toxicology. vol 31. issue 6. 2017-03-01. PMID:25409620. |
tunel-positive apoptotic cells as well as the expression of bcl2, bclxl, bax, and bad of exocrine pancreas did not show significant changes in the treated mice, indicating that aroclor 1254 has no effect on apoptosis. |
2017-03-01 |
2023-08-13 |
mouse |
| Zhengxing Xie, Ping Han, Zhenwen Cui, Baofeng Wang, Zhihong Zhong, Yuhao Sun, Guoyuan Yang, Qingfang Sun, Liuguan Bia. Pretreatment of Mouse Neural Stem Cells with Carbon Monoxide-Releasing Molecule-2 Interferes with NF-κB p65 Signaling and Suppresses Iron Overload-Induced Apoptosis. Cellular and molecular neurobiology. vol 36. issue 8. 2017-02-21. PMID:26961543. |
tunel staining showed that preconditioning c17.2 cells with corm-2 enhanced their resistance to apoptosis induced by iron overload, which was concomitant with down-regulation of the pro-apoptotic proteins (bax and cleaved caspase-3) and up-regulation of the anti-apoptotic protein bcl2. |
2017-02-21 |
2023-08-13 |
mouse |