| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Jain, T Jain, P Kumar, M Kumar, S De, M Gohain, R Kumar, T K Datt. Follicle-stimulating hormone-induced rescue of cumulus cell apoptosis and enhanced development ability of buffalo oocytes. Domestic animal endocrinology. vol 55. 2016-12-13. PMID:26774556. |
fsh supplementation in in vitro maturation-medium resulted in a dose-dependent reduction in the expression of proapoptotic genes namely, bcl2-associated x protein (bax), cytochrome c, and caspase-3 and increase in the expression of antiapoptotic genes such as b-cell lymphoma 2 (bcl2) and x-linked inhibitor of apoptosis protein (xiap) in cumulus cells of mature oocyte. |
2016-12-13 |
2023-08-13 |
Not clear |
| You-Cui Wang, Guo-Ying Feng, Qing-Jie Xia, Yue Hu, Yang Xu, Liu-Lin Xiong, Zhi-Wei Chen, Hang-Ping Wang, Ting-Hua Wang, Xue Zho. Knockdown of α-synuclein in cerebral cortex improves neural behavior associated with apoptotic inhibition and neurotrophin expression in spinal cord transected rats. Apoptosis : an international journal on programmed cell death. vol 21. issue 4. 2016-12-13. PMID:26822976. |
together, endogenous snca play a crucial role in motor and sensory function regulation, in which, the underlying mechanism may be linked to the regulation of apoptosis associated with apoptotic gene (bax, bcl2) and neurotrophic factors expression (ngf, bdnf and nt3). |
2016-12-13 |
2023-08-13 |
rat |
| Roberta Machado Ferreira, Marcos Roberto Chiaratti, Carolina Habermann Macabelli, Carlos Alberto Rodrigues, Márcio Leão Ferraz, Yeda Fumie Watanabe, Lawrence Charles Smith, Flávio Vieira Meirelles, Pietro Sampaio Barusell. The Infertility of Repeat-Breeder Cows During Summer Is Associated with Decreased Mitochondrial DNA and Increased Expression of Mitochondrial and Apoptotic Genes in Oocytes. Biology of reproduction. vol 94. issue 3. 2016-12-13. PMID:26843447. |
therefore, oocytes collected from heifers, non-rbs in peak lactation (pls), and rbs were used to evaluate mtdna amounts as well as the expression levels of genes associated with the mitochondria (mt-co1, nrf1, polg, polg2, ppargc1a, and tfam), apoptosis (bax, bcl2, and itm2b), and oocyte maturation (bmp15, fgf8, fgf10, fgf16, fgf17, and gdf9). |
2016-12-13 |
2023-08-13 |
Not clear |
| A Mohammadi, B Mansoori, S Goldar, D Shanehbandi, V Khaze, L Mohammadnejad, E Baghbani, B Baradara. Effects of Urtica dioica dichloromethane extract on cell apoptosis and related gene expression in human breast cancer cell line (MDA-MB-468). Cellular and molecular biology (Noisy-le-Grand, France). vol 62. issue 2. 2016-12-13. PMID:26950453. |
nuclei staining in tunel and dna fragments in dna fragmentation assay and increase in the mrna expression levels of caspase-3, caspase-9, decrease in the bcl2 and no significant change in the caspase-8 mrna expression level, showed that the induction of apoptosis was the main mechanism of cell death that induce by urtica dioica extract. |
2016-12-13 |
2023-08-13 |
human |
| Jianyu Feng, Yang Yang, Yajun Zhou, Bodong Wang, Hongyan Xiong, Chongxi Fan, Shuai Jiang, Jun Liu, Zhiqiang Ma, Wei Hu, Tian Li, Xiao Feng, Jianjun Xu, Zhenxiao Ji. Bakuchiol attenuates myocardial ischemia reperfusion injury by maintaining mitochondrial function: the role of silent information regulator 1. Apoptosis : an international journal on programmed cell death. vol 21. issue 5. 2016-12-13. PMID:27000151. |
bak exerted cardioprotective effects, as evidenced by the improvements noted in cardiac function following ischemia, attenuated myocardial apoptosis, and changes in several biochemical parameters (including increases in the level of the anti-apoptotic protein bcl2, decreases in the level of the pro-apoptotic protein bax, and decreases in the cleaved caspase 3 level). |
2016-12-13 |
2023-08-13 |
rat |
| Zhiguo Tong, Nan Liu, Luoqiang Lin, Xinggang Guo, Dongdong Yang, Qifan Zhan. miR-125a-5p inhibits cell proliferation and induces apoptosis in colon cancer via targeting BCL2, BCL2L12 and MCL1. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 75. 2016-11-08. PMID:26297542. |
mir-125a-5p inhibits cell proliferation and induces apoptosis in colon cancer via targeting bcl2, bcl2l12 and mcl1. |
2016-11-08 |
2023-08-13 |
Not clear |
| Zhiguo Tong, Nan Liu, Luoqiang Lin, Xinggang Guo, Dongdong Yang, Qifan Zhan. miR-125a-5p inhibits cell proliferation and induces apoptosis in colon cancer via targeting BCL2, BCL2L12 and MCL1. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 75. 2016-11-08. PMID:26297542. |
furthermore, restoration of bcl2, bcl2l12 and mcl-1 expression in colon cancer cells could partially reverse the cell proliferation inhibition and apoptosis stimulation caused by mir-125a-5p overexpression, indicating that mir-125a-5p inhibits cell proliferation and induces apoptosis in colon cancer cells via targeting bcl2, bcl2l12 and mcl-1. |
2016-11-08 |
2023-08-13 |
Not clear |
| Jiaming Gao, Qian Liu, Ying Xu, Xin Gong, Runyun Zhang, Chenglin Zhou, Zhaoliang Su, Jianhua Jin, Haifeng Shi, Juanjuan Shi, Yongzhong Ho. PPARα induces cell apoptosis by destructing Bcl2. Oncotarget. vol 6. issue 42. 2016-11-07. PMID:26556865. |
pparα induces cell apoptosis by destructing bcl2. |
2016-11-07 |
2023-08-13 |
Not clear |
| Deepti Chopra, Lipika Ray, Ashish Dwivedi, Shashi Kant Tiwari, Jyoti Singh, Krishna P Singh, Hari Narayan Kushwaha, Sadaf Jahan, Ankita Pandey, Shailendra K Gupta, Rajnish Kumar Chaturvedi, Aditya Bhushan Pant, Ratan Singh Ray, Kailash Chand Gupt. Photoprotective efficiency of PLGA-curcumin nanoparticles versus curcumin through the involvement of ERK/AKT pathway under ambient UV-R exposure in HaCaT cell line. Biomaterials. vol 84. 2016-11-07. PMID:26803409. |
molecular docking studies suggested that intact curcumin from nanoparticles, bind with bax in bim sahb site and attenuate it to undergo apoptosis while upregulating anti-apoptotic genes like bcl2. |
2016-11-07 |
2023-08-13 |
mouse |
| Kuo-Shyang Jeng, Chi-Juei Jeng, Wen-Juei Jeng, I-Shyan Sheen, Shih-Yun Li, Zih-Hang Hung, Hsin-I Hsiau, Ming-Che Yu, Chiung-Fang Chan. Liver epithelial cells inhibit proliferation and invasiveness of hepatoma cells. Oncology reports. vol 35. issue 3. 2016-10-27. PMID:26647726. |
there was a significant decrease in bcl2 expression and increase in late apoptosis of rat hepatoma cells when adding more rle cells. |
2016-10-27 |
2023-08-13 |
rat |
| Yi Yang, Xiang-Jian Zhang, Li-Tao Li, Hai-Ying Cui, Cong Zhang, Chun-Hua Zhu, Jiang-Yong Mia. Apelin-13 protects against apoptosis by activating AMP-activated protein kinase pathway in ischemia stroke. Peptides. vol 75. 2016-10-24. PMID:26631263. |
apelin-13, with the co-administration of saline, reduced apoptosis cells, down-regulated bax and cleaved-caspase3 and up-regulated bcl2. |
2016-10-24 |
2023-08-13 |
mouse |
| Yi Yang, Xiang-Jian Zhang, Li-Tao Li, Hai-Ying Cui, Cong Zhang, Chun-Hua Zhu, Jiang-Yong Mia. Apelin-13 protects against apoptosis by activating AMP-activated protein kinase pathway in ischemia stroke. Peptides. vol 75. 2016-10-24. PMID:26631263. |
however, with the co-administration of compound c, apelin-13 was inefficient in affecting apoptosis and bax, bcl2 and cleaved-caspase3. |
2016-10-24 |
2023-08-13 |
mouse |
| Yang Yang, Chongxi Fan, Chao Deng, Lin Zhao, Wei Hu, Shouyin Di, Zhiqiang Ma, Yu Zhang, Zhigang Qin, Zhenxiao Jin, Xiaolong Yan, Shuai Jiang, Yang Sun, Wei Y. Melatonin reverses flow shear stress-induced injury in bone marrow mesenchymal stem cells via activation of AMP-activated protein kinase signaling. Journal of pineal research. vol 60. issue 2. 2016-10-24. PMID:26707568. |
melatonin markedly reduced bmsc apoptotic death in a concentration-dependent manner while increasing the levels of transforming growth factor β (tgf-β), basic fibroblast growth factor (bfgf), vascular endothelial growth factor (vegf), platelet-derived growth factor (pdgf) and b-cell lymphoma 2 (bcl2), and decreasing those of bcl-2-associated x protein (bax), p53 upregulated modulator of apoptosis (puma), and caspase 3. |
2016-10-24 |
2023-08-13 |
Not clear |
| Xu-guang Chen, Yan-xia Lv, Dan Zhao, Lei Zhang, Fei Zheng, Jian-Ye Yang, Xiao-lin Li, Lu Wang, Lin-Yun Guo, Ya-mu Pan, Yu-wen Yan, Shi-You Chen, Jia-Ning Wang, Jun-Ming Tang, Yu Wa. Vascular endothelial growth factor-C protects heart from ischemia/reperfusion injury by inhibiting cardiomyocyte apoptosis. Molecular and cellular biochemistry. vol 413. issue 1-2. 2016-10-21. PMID:26769665. |
24 h later, the myocardial infarction size, the number of tunel-positive cardiomyocytes, the levels of creatine kinase (ck), ck-mb, cardiac troponin, malondialdehyde (mda) content, and apoptosis protein bax expression were decreased, while bcl2 and pakt expression were increased in vegf-c-treated myocardium as compared to the saline-treated i/r hearts. |
2016-10-21 |
2023-08-13 |
human |
| Fernanda Van Petten Vasconcelos Azevedo, Daiana Silva Lopes, Sarah Natalie Cirilo Gimenes, David Collares Achê, Lara Vecchi, Patrícia Terra Alves, Denise de Oliveira Guimarães, Renata Santos Rodrigues, Luiz Ricardo Goulart, Veridiana de Melo Rodrigues, Kelly Aparecida Geraldo Yoneyam. Human breast cancer cell death induced by BnSP-6, a Lys-49 PLA₂ homologue from Bothrops pauloensis venom. International journal of biological macromolecules. vol 82. 2016-10-13. PMID:26519876. |
apoptosis of mda-mb-231 cells was also confirmed by up-regulation of different genes related to the apoptosis pathway, such as tnf, tnfrsf10b, tnfrsf1a and casp8 and decreased expression of anti-apoptotic genes (bcl2 and bcl2l). |
2016-10-13 |
2023-08-13 |
human |
| Zhengwu Sun, Xiaoyan Lan, Anil Ahsan, Yalin Xi, Shumin Liu, Zonghui Zhang, Peng Chu, Yushu Song, Fengyuan Piao, Jinyong Peng, Yuan Lin, Guozhu Han, Zeyao Tan. Phosphocreatine protects against LPS-induced human umbilical vein endothelial cell apoptosis by regulating mitochondrial oxidative phosphorylation. Apoptosis : an international journal on programmed cell death. vol 21. issue 3. 2016-10-12. PMID:26708229. |
pcr protected huvecs against lps-induced apoptosis by suppressing the mitochondrial permeability transition, cytosolic release of cytochrome c (cyt c), ca(2+), reactive oxygen species and subsequent activation of caspases, and increasing bcl2 expression, while suppressing bax expression. |
2016-10-12 |
2023-08-13 |
human |
| Anna Szczerba, Aleksandra Śliwa, Marta Kubiczak, Ewa Nowak-Markwitz, Anna Jankowsk. Human chorionic gonadotropin β subunit affects the expression of apoptosis-regulating factors in ovarian cancer. Oncology reports. vol 35. issue 1. 2016-10-06. PMID:26530886. |
the material was tested against changes in expression level of genes encoding factors involved in apoptosis: bcl2, bax and birc5. |
2016-10-06 |
2023-08-13 |
human |
| Ruchi Saxena, Garima Gupta, Murli Manohar, Utsab Debnath, Pooja Popli, Yenamandra S Prabhakar, Rituraj Konwar, Sandeep Kumar, Atul Kumar, Anila Dwived. Spiro-oxindole derivative 5-chloro-4',5'-diphenyl-3'-(4-(2-(piperidin-1-yl) ethoxy) benzoyl) spiro[indoline-3,2'-pyrrolidin]-2-one triggers apoptosis in breast cancer cells via restoration of p53 function. The international journal of biochemistry & cell biology. vol 70. 2016-10-05. PMID:26556313. |
the activation of p53 led to upregulation of p53 dependent pro-apoptotic proteins, bax, pumaα and noxa and enhanced interaction of p53 with bcl2 member proteins thus triggering both transcription-dependent and transcription-independent apoptosis, respectively. |
2016-10-05 |
2023-08-13 |
Not clear |
| Ming Sun, Chuanxu Yang, Jin Zheng, Miao Wang, Muwan Chen, Dang Quang Svend Le, Jørgen Kjems, Cody Eric Bünge. Enhanced efficacy of chemotherapy for breast cancer stem cells by simultaneous suppression of multidrug resistance and antiapoptotic cellular defense. Acta biomaterialia. vol 28. 2016-09-23. PMID:26415776. |
the rationale is to sensitize cscs to dox by down regulating the drug-resistance gene abcg2 and simultaneously induce apoptosis by lowering bcl2 expression. |
2016-09-23 |
2023-08-13 |
human |
| Chengcao Sun, Ming Sang, Shujun Li, Xiaodong Sun, Cuili Yang, Yongyong Xi, Liang Wang, Feng Zhang, Yongyi Bi, Yunfeng Fu, Dejia L. Hsa-miR-139-5p inhibits proliferation and causes apoptosis associated with down-regulation of c-Met. Oncotarget. vol 6. issue 37. 2016-09-20. PMID:26497851. |
in addition, mir-139-5p induced apoptosis, as indicated by up-regulation of key apoptosis gene cleaved caspase-3, and down-regulation of anti-apoptosis gene bcl2. |
2016-09-20 |
2023-08-13 |
Not clear |