| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sadeesh Em, Fozia Shah, P S Yada. Differential developmental competence and gene expression patterns in buffalo (Bubalus bubalis) nuclear transfer embryos reconstructed with fetal fibroblasts and amnion mesenchymal stem cells. Cytotechnology. vol 68. issue 5. 2016-09-16. PMID:26660476. |
alterations in the expression pattern of genes implicated in transcription and pluripotency (oct4, stat3, nanog), dna methylation (dnmt1, dnmt3a), histone deacetylation (hdac2), growth factor signaling and imprinting (igf2, igf2r), apoptosis (bax, bcl2), metabolism (glut1) and oxidative stress (mnsod) regulation were observed in cloned embryos. |
2016-09-16 |
2023-08-13 |
Not clear |
| Shigeki Yagyu, Valentina Hoyos, Francesca Del Bufalo, Malcolm K Brenne. Multiple mechanisms determine the sensitivity of human-induced pluripotent stem cells to the inducible caspase-9 safety switch. Molecular therapy. Methods & clinical development. vol 3. 2016-09-14. PMID:27626039. |
we found that ic9-resistant hipsc have significant heterogeneity in terms of their escape mechanisms from caspase-dependent apoptosis including reduced expression of ic9 by promoter silencing and overexpression of bcl2. |
2016-09-14 |
2023-08-13 |
Not clear |
| Priyanka Halder, Ranjeet Kumar, Kuladip Jana, Sohini Chakraborty, Zhumur Ghosh, Manikuntala Kundu, Joyoti Bas. Gene expression profiling of Mycobacterium tuberculosis Lipoarabinomannan-treated macrophages: A role of the Bcl-2 family member A1 in inhibition of apoptosis in mycobacteria-infected macrophages. IUBMB life. vol 67. issue 9. 2016-09-13. PMID:26337784. |
we have demonstrated that manlam-dependent inhibition of macrophage apoptosis is mediated by the upregulation of the antiapoptotic b-cell cll/lymphoma 2 (bcl2) family member a1. |
2016-09-13 |
2023-08-13 |
Not clear |
| Riccardo Di Fiore, Rosa Drago-Ferrante, Francesca Pentimalli, Domenico Di Marzo, Iris Maria Forte, Daniela Carlisi, Anna De Blasio, Giovanni Tesoriere, Antonio Giordano, Renza Vent. Let-7d miRNA Shows Both Antioncogenic and Oncogenic Functions in Osteosarcoma-Derived 3AB-OS Cancer Stem Cells. Journal of cellular physiology. vol 231. issue 8. 2016-08-31. PMID:26679758. |
let-7d- overexpression also reduced cell sensitivity to apoptosis induced by both serum-starvation and various chemotherapy drugs, concomitant with decrease in caspase-3 and increase in bcl2 expression. |
2016-08-31 |
2023-08-13 |
human |
| Marvin Rubenstein, Courtney M P Hollowell, Patrick Guina. Suppression of BCL2 by Antisense Oligonucleotides and Compensation by Non-Targeted Genes May Enhance Tumor Proliferation. In vivo (Athens, Greece). vol 29. issue 6. 2016-08-29. PMID:26546525. |
our previous studies showed that oligonucleotide-treated lncap prostate cancer cells compensate for diminished expression of b-cell chronic lymphocytic leukemia/lymphoma 2 (bcl2), an apoptosis inhibitor, by suppressing the expression of caspase-3 (an apoptosis promoter) while enhancing that of serine/threonine protein kinase (akt1) (another apoptosis inhibitor). |
2016-08-29 |
2023-08-13 |
Not clear |
| Ying Ying, Huazhang Zhu, Zhen Liang, Xiaosong Ma, Shiwei L. GLP1 protects cardiomyocytes from palmitate-induced apoptosis via Akt/GSK3b/b-catenin pathway. Journal of molecular endocrinology. vol 55. issue 3. 2016-08-19. PMID:26386043. |
exposure of neonatal rat cardiomyocytes to palmitate increased the fatty acid transporter cd36-mediated intracellular lipid accumulation and cardiomyocyte apoptosis, decreased accumulation and nuclear translocation of active b-catenin, and reduced expression of b-catenin target protein survivin and bcl2. |
2016-08-19 |
2023-08-13 |
rat |
| Avi Harazi, Malka Chaouat, Zippora Shlomai, Robina Levitzki, Michal Becker-Cohen, Menachem Sadeh, Ron Dabby, Hannah Ben-Bassat, Stella Mitrani-Rosenbau. Survival-apoptosis associated signaling in GNE myopathy-cultured myoblasts. Journal of receptor and signal transduction research. vol 35. issue 4. 2016-08-16. PMID:25510413. |
in this study, we applied our model of mutated m743t gne enzyme skeletal muscle-cultured myoblasts and paired healthy controls to depict the pattern of signaling proteins controlling survival and/or apoptosis of the pi3k/akt, bcl2, arts/xiap pathways, examined the effects of metabolic changes/stimuli on their expression and activation, and their potential role in gnem. |
2016-08-16 |
2023-08-13 |
Not clear |
| Ibrahim Y Abdelrahman, Reham Helwa, Hausein Elkashef, Nagwa H A Hassa. Induction of P3NS1 Myeloma Cell Death and Cell Cycle Arrest by Simvastatin and/or γ-Radiation. Asian Pacific journal of cancer prevention : APJCP. vol 16. issue 16. 2016-08-16. PMID:26514497. |
the cell viability, induction of apoptosis, cell death, cell cycling, generation of ros, and expression of p53, bax, bcl2, caspase3, parp1 and fas genes were estimated. |
2016-08-16 |
2023-08-13 |
Not clear |
| V Bastos, J M P Ferreira de Oliveira, D Brown, H Jonhston, E Malheiro, A L Daniel-da-Silva, I F Duarte, C Santos, H Oliveir. The influence of Citrate or PEG coating on silver nanoparticle toxicity to a human keratinocyte cell line. Toxicology letters. vol 249. 2016-08-16. PMID:27021274. |
cit30 agnps clearly induced apoptotic death, while cells exposed to peg30 agnps appeared to be at an earlier phase of apoptosis, supported by changes in bax, bcl2 and casp-3 expressions. |
2016-08-16 |
2023-08-13 |
human |
| Yong Wang, Fenghong Huang, Liang Zhao, Di Zhang, Ou Wang, Xiaoxuan Guo, Feng Lu, Xue Yang, Baoping Ji, Qianchun Den. Protective Effect of Total Flavones from Hippophae rhamnoides L. against Visible Light-Induced Retinal Degeneration in Pigmented Rabbits. Journal of agricultural and food chemistry. vol 64. issue 1. 2016-08-11. PMID:26653970. |
tfh ameliorated the retinal oxidative stress (gsh-px, cat, t-aoc, and mda), inflammation (il-1β and il-6), angiogenesis (vegf), and apoptosis (bax, bcl2, and caspase-3) induced by light exposure. |
2016-08-11 |
2023-08-13 |
cat |
| Harish Chandra Pal, Ronald D Baxter, Katherine M Hunt, Jyoti Agarwal, Craig A Elmets, Mohammad Athar, Farrukh Afa. Fisetin, a phytochemical, potentiates sorafenib-induced apoptosis and abrogates tumor growth in athymic nude mice implanted with BRAF-mutated melanoma cells. Oncotarget. vol 6. issue 29. 2016-08-02. PMID:26299806. |
in addition, combination treatment resulted in enhanced (i) apoptosis, (ii) cleavage of caspase-3 and parp, (iii) expression of bax and bak, (iv) inhibition of bcl2 and mcl-1, and (v) inhibition of expression of pi3k, phosphorylation of mek1/2, erk1/2, akt and mtor. |
2016-08-02 |
2023-08-13 |
mouse |
| Xiaoming Wang, Minran Zhou, Yue Fu, Ting Sun, Jin Chen, Xuemei Qin, Yuan Yu, Jihui Jia, Chunyan Che. RBP2 Promotes Adult Acute Lymphoblastic Leukemia by Upregulating BCL2. PloS one. vol 11. issue 3. 2016-08-02. PMID:27008505. |
as the role of rbp2 in regulating apoptosis was confirmed, rbp2 overexpression and activation of bcl2 might play important roles in all development and progression. |
2016-08-02 |
2023-08-13 |
Not clear |
| Ramesh Choudhari, Valerio Giacomo Minero, Matteo Menotti, Roberta Pulito, Cord Brakebusch, Mara Compagno, Claudia Voena, Chiara Ambrogio, Roberto Chiarl. Redundant and nonredundant roles for Cdc42 and Rac1 in lymphomas developed in NPM-ALK transgenic mice. Blood. vol 127. issue 10. 2016-08-01. PMID:26747246. |
apoptosis of lymphoma cells was equally induced following cdc42 or rac1 deletion, was associated with upregulation of the proapoptotic molecule bid, and was blocked by bcl2 overexpression. |
2016-08-01 |
2023-08-13 |
mouse |
| Sadeesh Em, Fozia Shah, Meena Kataria, P S Yada. A comparative study on expression profile of developmentally important genes during pre-implantation stages in buffalo hand-made cloned embryos derived from adult fibroblasts and amniotic fluid derived stem cells. Cytotechnology. vol 68. issue 4. 2016-07-26. PMID:26224482. |
alterations in the expression pattern of genes implicated in transcription and pluripotency (oct4, stat3, nanog), dna methylation (dnmt1, dnmt3a), histone deacetylation (hdac2), growth factor signaling, and imprinting (igf2, igf2r), apoptosis (bax, bcl2), oxidative stress (mnsod), metabolism (glut1) regulation were observed in cloned embryos. |
2016-07-26 |
2023-08-13 |
Not clear |
| Chengcao Sun, Zhidong Liu, Shujun Li, Cuili Yang, Ruilin Xue, Yongyong Xi, Liang Wang, Suqing Wang, Qiqiang He, Jie Huang, Songping Xie, Wenyang Jiang, Dejia L. Down-regulation of c-Met and Bcl2 by microRNA-206, activates apoptosis, and inhibits tumor cell proliferation, migration and colony formation. Oncotarget. vol 6. issue 28. 2016-07-25. PMID:26325180. |
down-regulation of c-met and bcl2 by microrna-206, activates apoptosis, and inhibits tumor cell proliferation, migration and colony formation. |
2016-07-25 |
2023-08-13 |
human |
| Caina Xu, Ping Wang, Jingpeng Zhang, Huayu Tian, Kinam Park, Xuesi Che. Pulmonary Codelivery of Doxorubicin and siRNA by pH-Sensitive Nanoparticles for Therapy of Metastatic Lung Cancer. Small (Weinheim an der Bergstrasse, Germany). vol 11. issue 34. 2016-07-19. PMID:26136261. |
moreover, pei-ca-dox/bcl2 sirna complex nanoparticles show higher cytotoxicity and apoptosis induction in b16f10 cells than those treated with either dox or bcl2 sirna alone. |
2016-07-19 |
2023-08-13 |
mouse |
| Juhyun Song, So Yeong Cheon, Won Taek Lee, Kyung Ah Park, Jong Eun Le. PKA Inhibitor H89 (N-[2-p-bromocinnamylamino-ethyl]-5-isoquinolinesulfonamide) Attenuates Synaptic Dysfunction and Neuronal Cell Death following Ischemic Injury. Neural plasticity. vol 2015. 2016-07-19. PMID:26448879. |
next, we examined the role of h89 pretreatment on the expression of brain-derived neurotrophic factor (bdnf), psd95, map2, and the apoptosis regulators bcl2 and cleaved caspase-3 in cultured neuroblastoma cells exposed to hypoxia and reperfusion injury. |
2016-07-19 |
2023-08-13 |
mouse |
| Zhenkun Ma, Wei Liu, Jin Zeng, Jiancheng Zhou, Peng Guo, Hongjun Xie, Zhao Yang, Long Zheng, Shan Xu, Xinyang Wang, Luke S Chang, Dalin He, Lei L. Silibinin induces apoptosis through inhibition of the mTOR-GLI1-BCL2 pathway in renal cell carcinoma. Oncology reports. vol 34. issue 5. 2016-07-18. PMID:26323996. |
in the present study, we confirmed that silibinin induced growth inhibition of rcc through caspase-dependent apoptosis and downregulation of gli1 and bcl2, which could be partially reversed by gli1 overexpression. |
2016-07-18 |
2023-08-13 |
mouse |
| Vítor Sousa, Bruno Bastos, Maria Silva, Ana Maria Alarcão, Lina Carvalh. Bronchial-pulmonary adenocarcinoma subtyping relates with different molecular pathways. Revista portuguesa de pneumologia. vol 21. issue 5. 2016-07-13. PMID:25926247. |
inhibition of apoptosis could be explained by bcl2 overexpression, present in all adenocarcinoma patterns. |
2016-07-13 |
2023-08-13 |
Not clear |
| P Zhu, M Y Zhao, X H Li, Q Fu, Z F Zhou, C F Huang, X S Zhang, H L Huang, Y Tan, J X Li, J N Li, S Huang, M Ashraf, C Lu, J M Chen, J Zhuang, H M Gu. Effect of low temperatures on BAX and BCL2 proteins in rats with spinal cord ischemia reperfusion injury. Genetics and molecular research : GMR. vol 14. issue 3. 2016-07-06. PMID:26400280. |
motor function of the lower limbs was evaluated according to the tarlov score at 72 and 168 h. for each rat, spinal cord samples were taken at 6, 24, 72 h, and 1 week to evaluate the histopathological changes, neuronal apoptosis, and bax and bcl2 expression levels. |
2016-07-06 |
2023-08-13 |
rat |