| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rui Hu, Fengqing Hu, Xiao Xie, Lei Wang, Guoqing Li, Tong Qiao, Mingsong Wang, Haibo Xia. TMEM45B, up-regulated in human lung cancer, enhances tumorigenicity of lung cancer cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 9. 2017-02-21. PMID:27225290. |
moreover, knockdown of tmem45b significantly suppressed g1/s transition, induced cell apoptosis, and inhibited cell invasion via regulating the expression of cell cycle-related proteins (cdk2, cdc25a, and pcna), cell apoptosis-related proteins (bcl2, bax, and cleaved caspase 3), and metastasis-related proteins (mmp-9, twist, and snail), respectively. |
2017-02-21 |
2023-08-13 |
mouse |
| Patricia Morcillo, José Meseguer, M Ángeles Esteban, Alberto Cuest. In vitro effects of metals on isolated head-kidney and blood leucocytes of the teleost fish Sparus aurata L. and Dicentrarchus labrax L. Fish & shellfish immunology. vol 54. 2017-02-17. PMID:27041665. |
in addition, this profile leads to the increase of expression in genes related to apoptosis (bcl2 associated x protein and caspase 3). |
2017-02-17 |
2023-08-13 |
Not clear |
| M A Behdani, R Hoshya. Phytochemical properties of Iranian organic saffron stigma: antioxidant, anticancer and apoptotic approaches. Cellular and molecular biology (Noisy-le-Grand, France). vol 62. issue 14. 2017-02-16. PMID:28145859. |
herb-induced apoptosis associated with increased expression of bax and decreased bcl2 gene leading eventually to a time-dependent increase in bax/bcl-2 ratio. |
2017-02-16 |
2023-08-13 |
Not clear |
| Quanxin Gao, Qian Gao, Minghua Min, Chenjie Zhang, Shiming Peng, Zhaohong Sh. Ability of Lactobacillus plantarum lipoteichoic acid to inhibit Vibrio anguillarum-induced inflammation and apoptosis in silvery pomfret (Pampus argenteus) intestinal epithelial cells. Fish & shellfish immunology. vol 54. 2017-02-14. PMID:27179425. |
it also showed significant inhibitory effects on ehec-induced inflammation and apoptosis by modulating the expression of nf-κb (nuclear factor kappa b), iκb (inhibitor of nf-κb), bcl2 (b-cell leukemia/lymphoma-2), bax (bcl-2-associated x protein), il-8 (interleukin 8) and tnf-α (tumor necrosis factor-α), and via inhibition of caspase-9 and caspase-3 activation. |
2017-02-14 |
2023-08-13 |
Not clear |
| Sandip Kumar Rath, Moonmoon Deb, Dipta Sengupta, Vijayalaxmi Kari, Swayamsiddha Kar, Sabnam Parbin, Nibedita Pradhan, Samir Kumar Patr. Silencing of ZRF1 impedes survival of estrogen receptor positive MCF-7 cells and potentiates the effect of curcumin. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 9. 2017-02-14. PMID:27350366. |
moreover, the decrease in viability of mcf-7 cells was accompanied by induction of apoptosis and dna damage, well-marked with upregulation of cleaved parp and downregulation of bcl2 and h2aubk119 levels. |
2017-02-14 |
2023-08-13 |
Not clear |
| Verónica Bastos, José M P Ferreira-de-Oliveira, Joana Carrola, Ana L Daniel-da-Silva, Iola F Duarte, Conceição Santos, Helena Oliveir. Coating independent cytotoxicity of citrate- and PEG-coated silver nanoparticles on a human hepatoma cell line. Journal of environmental sciences (China). vol 51. 2017-02-09. PMID:28115130. |
at the concentrations used (11 and 5μg/ml corresponding to ic50 and ~ic10 levels, respectively) the amount of cells undergoing apoptosis was not significant and the apoptotic related genes bcl2 (anti-apoptotic gene) and bax (pro-apoptotic gene) were both downregulated. |
2017-02-09 |
2023-08-13 |
human |
| Andrew W Robert. Targeting apoptotic pathways to treat lymphoid malignancies. [Rinsho ketsueki] The Japanese journal of clinical hematology. vol 57. issue 10. 2017-02-08. PMID:27795514. |
consequently, many haematological malignancies also harbour aberrations that circumvent apoptosis, with aberrations of tp53 and the bcl2 family being the most common. |
2017-02-08 |
2023-08-13 |
Not clear |
| Andrew W Robert. Targeting apoptotic pathways to treat lymphoid malignancies. [Rinsho ketsueki] The Japanese journal of clinical hematology. vol 57. issue 10. 2017-02-08. PMID:27795514. |
this educational lecture focuses on current understanding of the role of the intrinsic pathway to apoptosis in lymphoid cancers, its regulation by bcl2 and related proteins, and emerging data on the therapeutic potential of inhibiting bcl2 to induce apoptosis in bcl2-expressing b cell cancers. |
2017-02-08 |
2023-08-13 |
Not clear |
| Sadegh Lotfalah Moradi, Gita Eslami, Hossein Goudarzi, Zahra Hajishafieeha, Masoud Soleimani, Adel Mohammadzadeh, Abdolreza Ardeshirylajim. Role of Helicobacter pylori on cancer of human adipose-derived mesenchymal stem cells and metastasis of tumor cells-an in vitro study. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 3. 2017-02-07. PMID:26446460. |
our results demonstrated that h. pylori tries to improve the ha-mscs carcinogenic activities by overexpression of bcl2 gene as an anti-apoptosis agent against the p53 gene expression as main apoptosis agent. |
2017-02-07 |
2023-08-13 |
human |
| Lulu Bai, Yu Guo, Yue Du, Huaxin Wang, Zhiying Zhao, Yuhong Huang, Jianwu Tan. 47kDa isoform of Annexin A7 affecting the apoptosis of mouse hepatocarcinoma cells line. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 83. 2017-02-07. PMID:27551759. |
these results indicate that 47kda isoform of annexin a7 could associated with the apoptosis of hca-p cells through its interaction with bcl2. |
2017-02-07 |
2023-08-13 |
mouse |
| Manel Boussabbeh, Intidhar Ben Salem, Karima Rjiba-Touati, Chedy Bouyahya, Fadwa Neffati, Mohamed Fadhel Najjar, Hassen Bacha, Salwa Abid-Essef. The potential effect of patulin on mice bearing melanoma cells: an anti-tumour or carcinogenic effect? Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 5. 2017-02-06. PMID:26619846. |
this effect was evidenced by the activation of apoptosis which is supported by the increase in p53 and bax expressions, the downregulation of the protein levels of bcl2, and the increase in caspase-3 activity. |
2017-02-06 |
2023-08-13 |
mouse |
| Akram Sadeghirizi, Razieh Yazdanparast, Safiyeh Aghazade. Combating trastuzumab resistance by targeting thioredoxin-1/PTEN interaction. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 5. 2017-02-06. PMID:26662109. |
treatment of the cells with px-12 (5 μm) and trastuzumab (10 μg/ml) reduced cells viabilities, p-akt, and bcl2 levels while increasing the levels of reactive oxygen species (ros) and p-jnk with consequent higher levels of g1 arrest and apoptosis among the resistant cells compared to parental trastuzumab sensitive cells. |
2017-02-06 |
2023-08-13 |
human |
| Ruth Ruiz Esparza-Garrido, María Eugenia Torres-Márquez, Rubí Viedma-Rodríguez, Ana Claudia Velázquez-Wong, Fabio Salamanca-Gómez, Haydeé Rosas-Vargas, Miguel Ángel Velázquez-Flore. Breast cancer cell line MDA-MB-231 miRNA profile expression after BIK interference: BIK involvement in autophagy. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 5. 2017-02-06. PMID:26662110. |
b-cell lymphoma 2 (bcl2)-interacting killer (apoptosis inducing) (bik) has been proposed as a tumor suppressor in diverse types of cancers. |
2017-02-06 |
2023-08-13 |
Not clear |
| Phanni Bhushann Meka, Sarika Jarjapu, Sandeep Kumar Vishwakarma, Santhoshi Rani Nanchari, Anuradha Cingeetham, Sandhya Annamaneni, Srinivasulu Mukta, B Triveni, Vishnupriya Satt. Influence of BCL2-938 C>A promoter polymorphism and BCL2 gene expression on the progression of breast cancer. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 5. 2017-02-06. PMID:26662799. |
further, aa genotype was found to be associated with advanced stage tumors, node positive status, and high ki67 proliferation index compared to ca and cc genotypes indicating that elevated expression of bcl2 gene in the presence of a allele might be associated with decreased apoptosis and enhanced proliferation rate. |
2017-02-06 |
2023-08-13 |
Not clear |
| Phanni Bhushann Meka, Sarika Jarjapu, Sandeep Kumar Vishwakarma, Santhoshi Rani Nanchari, Anuradha Cingeetham, Sandhya Annamaneni, Srinivasulu Mukta, B Triveni, Vishnupriya Satt. Influence of BCL2-938 C>A promoter polymorphism and BCL2 gene expression on the progression of breast cancer. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 5. 2017-02-06. PMID:26662799. |
probably, failure of apoptosis due to enhanced expression and antiapoptotic protein bcl2 might promote malignant growth. |
2017-02-06 |
2023-08-13 |
Not clear |
| Deepshikha Mishra, Sunita Singh, Gopeshwar Naraya. Curcumin Induces Apoptosis in Pre-B Acute Lymphoblastic Leukemia Cell Lines Via PARP-1 Cleavage. Asian Pacific journal of cancer prevention : APJCP. vol 17. issue 8. 2017-02-01. PMID:27644631. |
an increased level of caspase-3, apoptosis inducing factor (aif), cleaved parp-1 and decreased level of bcl2 was observed in leukemia cells after 24h of curcumin treatment. |
2017-02-01 |
2023-08-13 |
Not clear |
| Mahmoud El-Bendary, Samia Hawas, Dina El-Hammady, Al-Hadidy Mohammed Al-Hadidy, Heba Eldegl. Profile of expression of certain markers of apoptosis in chronic hepatitis C and hepatitis B patients in an Egyptian population. Archives of virology. vol 161. issue 9. 2017-01-31. PMID:27262945. |
no significant difference in the level of apoptosis, fas, or bcl2 expression between chc and chb patients was detected. |
2017-01-31 |
2023-08-13 |
Not clear |
| AbdelRahman N Zekri, Esraa Sobhy, Nehal Hussein, Ola S Ahmed, Amira Hussein, Sahar Shoman, Amira H Soliman, Hanaa M Alam ElDi. E1/E2 of Hepatitis C Virus Genotype4 and Apoptosis. Asian Pacific journal of cancer prevention : APJCP. vol 17. issue 7. 2017-01-25. PMID:27509941. |
these results suggest that the e1/e2 proteins may be involved in hcvinduced pathogenesis by modulating apoptosis through the induction of the intrinsic apoptosis pathway and disruption of the bcl2 gene family. |
2017-01-25 |
2023-08-13 |
human |
| Partha Mitra, Ren-Ming Yang, James Sutton, Robert G Ramsay, Thomas J Gond. CDK9 inhibitors selectively target estrogen receptor-positive breast cancer cells through combined inhibition of MYB and MCL-1 expression. Oncotarget. vol 7. issue 8. 2016-12-30. PMID:26812885. |
nevertheless, inhibition of bcl2 alone either by myb knockdown or by abt-199 treatment was insufficient for significant induction of apoptosis. |
2016-12-30 |
2023-08-13 |
Not clear |
| Patrick J Metz, Justine Lopez, Stephanie H Kim, Kazunori Akimoto, Shigeo Ohno, John T Chan. Regulation of Asymmetric Division by Atypical Protein Kinase C Influences Early Specification of CD8(+) T Lymphocyte Fates. Scientific reports. vol 6. 2016-12-26. PMID:26765121. |
however, unlike cd8(+) t cells deficient in only one apkc isoform, complete loss of apkc unexpectedly increased cd8(+) t cell differentiation toward a short-lived, terminal effector fate, as evidenced by increased rates of apoptosis and decreased expression of eomes and bcl2 early during the immune response. |
2016-12-26 |
2023-08-13 |
Not clear |