| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ruth Ruiz Esparza-Garrido, María Eugenia Torres-Márquez, Rubí Viedma-Rodríguez, Ana Claudia Velázquez-Wong, Fabio Salamanca-Gómez, Haydeé Rosas-Vargas, Miguel Ángel Velázquez-Flore. Breast cancer cell line MDA-MB-231 miRNA profile expression after BIK interference: BIK involvement in autophagy. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 5. 2017-02-06. PMID:26662110. |
b-cell lymphoma 2 (bcl2)-interacting killer (apoptosis inducing) (bik) has been proposed as a tumor suppressor in diverse types of cancers. |
2017-02-06 |
2023-08-13 |
Not clear |
| Phanni Bhushann Meka, Sarika Jarjapu, Sandeep Kumar Vishwakarma, Santhoshi Rani Nanchari, Anuradha Cingeetham, Sandhya Annamaneni, Srinivasulu Mukta, B Triveni, Vishnupriya Satt. Influence of BCL2-938 C>A promoter polymorphism and BCL2 gene expression on the progression of breast cancer. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 5. 2017-02-06. PMID:26662799. |
further, aa genotype was found to be associated with advanced stage tumors, node positive status, and high ki67 proliferation index compared to ca and cc genotypes indicating that elevated expression of bcl2 gene in the presence of a allele might be associated with decreased apoptosis and enhanced proliferation rate. |
2017-02-06 |
2023-08-13 |
Not clear |
| Phanni Bhushann Meka, Sarika Jarjapu, Sandeep Kumar Vishwakarma, Santhoshi Rani Nanchari, Anuradha Cingeetham, Sandhya Annamaneni, Srinivasulu Mukta, B Triveni, Vishnupriya Satt. Influence of BCL2-938 C>A promoter polymorphism and BCL2 gene expression on the progression of breast cancer. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 5. 2017-02-06. PMID:26662799. |
probably, failure of apoptosis due to enhanced expression and antiapoptotic protein bcl2 might promote malignant growth. |
2017-02-06 |
2023-08-13 |
Not clear |
| Deepshikha Mishra, Sunita Singh, Gopeshwar Naraya. Curcumin Induces Apoptosis in Pre-B Acute Lymphoblastic Leukemia Cell Lines Via PARP-1 Cleavage. Asian Pacific journal of cancer prevention : APJCP. vol 17. issue 8. 2017-02-01. PMID:27644631. |
an increased level of caspase-3, apoptosis inducing factor (aif), cleaved parp-1 and decreased level of bcl2 was observed in leukemia cells after 24h of curcumin treatment. |
2017-02-01 |
2023-08-13 |
Not clear |
| Mahmoud El-Bendary, Samia Hawas, Dina El-Hammady, Al-Hadidy Mohammed Al-Hadidy, Heba Eldegl. Profile of expression of certain markers of apoptosis in chronic hepatitis C and hepatitis B patients in an Egyptian population. Archives of virology. vol 161. issue 9. 2017-01-31. PMID:27262945. |
no significant difference in the level of apoptosis, fas, or bcl2 expression between chc and chb patients was detected. |
2017-01-31 |
2023-08-13 |
Not clear |
| AbdelRahman N Zekri, Esraa Sobhy, Nehal Hussein, Ola S Ahmed, Amira Hussein, Sahar Shoman, Amira H Soliman, Hanaa M Alam ElDi. E1/E2 of Hepatitis C Virus Genotype4 and Apoptosis. Asian Pacific journal of cancer prevention : APJCP. vol 17. issue 7. 2017-01-25. PMID:27509941. |
these results suggest that the e1/e2 proteins may be involved in hcvinduced pathogenesis by modulating apoptosis through the induction of the intrinsic apoptosis pathway and disruption of the bcl2 gene family. |
2017-01-25 |
2023-08-13 |
human |
| Partha Mitra, Ren-Ming Yang, James Sutton, Robert G Ramsay, Thomas J Gond. CDK9 inhibitors selectively target estrogen receptor-positive breast cancer cells through combined inhibition of MYB and MCL-1 expression. Oncotarget. vol 7. issue 8. 2016-12-30. PMID:26812885. |
nevertheless, inhibition of bcl2 alone either by myb knockdown or by abt-199 treatment was insufficient for significant induction of apoptosis. |
2016-12-30 |
2023-08-13 |
Not clear |
| Patrick J Metz, Justine Lopez, Stephanie H Kim, Kazunori Akimoto, Shigeo Ohno, John T Chan. Regulation of Asymmetric Division by Atypical Protein Kinase C Influences Early Specification of CD8(+) T Lymphocyte Fates. Scientific reports. vol 6. 2016-12-26. PMID:26765121. |
however, unlike cd8(+) t cells deficient in only one apkc isoform, complete loss of apkc unexpectedly increased cd8(+) t cell differentiation toward a short-lived, terminal effector fate, as evidenced by increased rates of apoptosis and decreased expression of eomes and bcl2 early during the immune response. |
2016-12-26 |
2023-08-13 |
Not clear |
| H Kauser, S Sahu, U Panjwan. Guanfacine promotes neuronal survival in medial prefrontal cortex under hypobaric hypoxia. Brain research. vol 1636. 2016-12-21. PMID:26854138. |
further, change in bax to bcl2 ratio was in correlation with caspase3 expression in layer ii of the medial pfc, indicating that caspase3 is responsible for bcl2 cleavage and hence modulation of apoptosis. |
2016-12-21 |
2023-08-13 |
rat |
| Chengcao Sun, Chuanfeng Huang, Shujun Li, Cuili Yang, Yongyong Xi, Liang Wang, Feng Zhang, Yunfeng Fu, Dejia L. Hsa-miR-326 targets CCND1 and inhibits non-small cell lung cancer development. Oncotarget. vol 7. issue 7. 2016-12-20. PMID:26840018. |
in addition, mir-326 induced apoptosis, as indicated by concomitantly with up-regulation of key apoptosis protein cleaved caspase-3, and down-regulation of anti-apoptosis protein bcl2. |
2016-12-20 |
2023-08-13 |
Not clear |
| Yongyan Wu, Zekun Guo, Kezhen Yao, Yue Miao, Shuxin Liang, Fayang Liu, Yongsheng Wang, Yong Zhan. The Transcriptional Foundations of Sp110-mediated Macrophage (RAW264.7) Resistance to Mycobacterium tuberculosis H37Ra. Scientific reports. vol 6. 2016-12-19. PMID:26912204. |
additionally, our results showed that sp110 upregulates bcl2 modifying factor (bmf) by inhibiting mir-125a, and forced expression of bmf induces macrophage apoptosis. |
2016-12-19 |
2023-08-13 |
human |
| Hua Guan, Yan Lin, Liang Bai, Yingfeng An, Jianan Shang, Zhao Wang, Sihai Zhao, Jianglin Fan, Enqi Li. Dietary Cocoa Powder Improves Hyperlipidemia and Reduces Atherosclerosis in apoE Deficient Mice through the Inhibition of Hepatic Endoplasmic Reticulum Stress. Mediators of inflammation. vol 2016. 2016-12-19. PMID:26980943. |
analysis of mrna profiling of aortic atherosclerotic lesions revealed that the expression of several genes related to apoptosis, lipid metabolism, and inflammation was significantly reduced, while the antiapoptotic gene bcl2 was significantly increased in the cocoa powder group compared to the control. |
2016-12-19 |
2023-08-13 |
mouse |
| Zhong Wu, Pengfei Zan, Shaohua Li, Jie Liu, Jianguang Wang, Dong Chen, Hua Wang, Yongqiang Qian, Linjie Luo, Xiang Huan. Knockdown of WWP1 inhibits growth and invasion, but induces apoptosis of osteosarcoma cells. International journal of clinical and experimental pathology. vol 8. issue 7. 2016-12-14. PMID:26339351. |
furthermore, knocking down wwp1 affected the protein levels of apoptosis (bcl2 and bax) and invasion related factor (mmp2, mmp9, β-catenin and e-cadherin). |
2016-12-14 |
2023-08-13 |
Not clear |
| Yewei Liu, Qian Reuben Xie, Boshi Wang, Jiaxiang Shao, Tingting Zhang, Tengyuan Liu, Gang Huang, Weiliang Xi. Inhibition of SIRT6 in prostate cancer reduces cell viability and increases sensitivity to chemotherapeutics. Protein & cell. vol 4. issue 9. 2016-12-13. PMID:23982738. |
knockdown of sirt6 in human prostate cancer cells led to sub-g1 phase arrest of cell cycle, increased apoptosis, elevated dna damage level and decrease in bcl2 gene expression. |
2016-12-13 |
2023-08-12 |
human |
| Zheng Zhenzhong, Yu Yafa, Liang Ji. Fibrinogen-like protein 2 gene silencing inhibits cardiomyocytes apoptosis, improves heart function of streptozotocin-induced diabetes rats and the molecular mechanism involved. Bioscience reports. vol 35. issue 3. 2016-12-13. PMID:26182381. |
we found that fgl2 gene silencing inhibits apoptosis and improves heart function of streptozotocin (stz)-induced diabetes rats, the possible mechanism maybe that fgl2 gene silencing reduces the tumour necrosis factor (tnf)±levels, decreases the expression of b-cell lymphoma-2 (bcl2), bcl-2-associated x (bax), toll-like receptors 4 (tlr4) and p38 mitogen-activated protein kinase (mapk). |
2016-12-13 |
2023-08-13 |
rat |
| M Sochalska, E Ottina, S Tuzlak, S Herzog, M Herold, A Villunge. Conditional knockdown of BCL2A1 reveals rate-limiting roles in BCR-dependent B-cell survival. Cell death and differentiation. vol 23. issue 4. 2016-12-13. PMID:26450454. |
bcl2 family proteins control mitochondrial apoptosis and its members exert critical cell type and differentiation stage-specific functions, acting as barriers against autoimmunity or transformation. |
2016-12-13 |
2023-08-13 |
mouse |
| JeHoon Lee, Sakhila K Banu, John A McCracken, Joe A Aros. Early pregnancy modulates survival and apoptosis pathways in the corpus luteum in sheep. Reproduction (Cambridge, England). vol 151. issue 3. 2016-12-13. PMID:26585285. |
results indicate that: i) expressions of p-erk1/2, p-akt, β-catenin, nfκb -p65, -p50, -p52, p-src, p-β -arrestin, p-gsk3β, x-linked inhibitor of apoptosis protein (xiap), and p-creb proteins are suppressed during natural luteolysis; in contrast, their expressions are sustained or increased during establishment of pregnancy; ii) expressions of cleaved caspase-3, apoptosis inducing factor (aif), c-fos, c-jun, and egr-1 proteins are increased during natural luteolysis; in contrast, their expressions are decreased during establishment of pregnancy; and iii) expressions of bcl-2, bcl-xl, bad, and bax proteins are not modulated during natural luteolysis while expressions of bcl2 and bcl-xl proteins are increased during establishment of pregnancy in sheep. |
2016-12-13 |
2023-08-13 |
Not clear |
| Richa Singh, Vikas Yadav, Sachin Kumar, Neeru Sain. MicroRNA-195 inhibits proliferation, invasion and metastasis in breast cancer cells by targeting FASN, HMGCR, ACACA and CYP27B1. Scientific reports. vol 5. 2016-12-13. PMID:26632252. |
previously we demonstrated that hsa-mir-195 targets bcl2, induces apoptosis and augmented the effect of etoposide in breast cancer cells. |
2016-12-13 |
2023-08-13 |
Not clear |
| Jian-Jun Lu, Lingyi Fu, Zhipeng Tang, Changlin Zhang, Lijun Qin, Jingshu Wang, Zhenlong Yu, Dingbo Shi, Xiangsheng Xiao, Fangyun Xie, Wenlin Huang, Wuguo Den. Melatonin inhibits AP-2β/hTERT, NF-κB/COX-2 and Akt/ERK and activates caspase/Cyto C signaling to enhance the antitumor activity of berberine in lung cancer cells. Oncotarget. vol 7. issue 3. 2016-12-13. PMID:26672764. |
further mechanism study showed that melatonin promoted the cleavage of caspse-9 and parp, enhanced the inhibition of bcl2, and triggered the releasing of cytochrome c (cyto c), thereby increasing the berberine-induced apoptosis. |
2016-12-13 |
2023-08-13 |
human |
| Anupam Bishayee, Animesh Mandal, Piyali Bhattacharyya, Deepak Bhati. Pomegranate exerts chemoprevention of experimentally induced mammary tumorigenesis by suppression of cell proliferation and induction of apoptosis. Nutrition and cancer. vol 68. issue 1. 2016-12-13. PMID:26699876. |
thus, pe exerts chemoprevention of mammary carcinogenesis by suppressing cell proliferation and inducing apoptosis mediated through upregulation of bax and downregulation of bcl2 in concert with caspase cascades. |
2016-12-13 |
2023-08-13 |
rat |