| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lixian Cheng, Hui Shi, Yan Jin, Xiaoxi Li, Jinshun Pan, Yimei Lai, Yan Lin, Ya Jin, Gaurab Roy, Allan Zhao, Fanghong L. Adiponectin Deficiency Leads to Female Subfertility and Ovarian Dysfunctions in Mice. Endocrinology. vol 157. issue 12. 2017-05-26. PMID:27700136. |
adiponectin deficiency also altered the peak concentrations of lh surge and led to lower expression of cytochrome p450 family 11 subfamily a member 1 (p450scc), an enzyme critical for progesterone synthesis, as well as an increase in bcl2 associated x, apoptosis regulator and insulin like growth factor binding protein 4 in atretic follicles. |
2017-05-26 |
2023-08-13 |
mouse |
| Xiaoling Guo, Deliang Zhu, Ruiling Lian, Yuting Han, Yonglong Guo, Zhijie Li, Shibo Tang, Jiansu Che. Matrigel and Activin A promote cell-cell contact and anti-apoptotic activity in cultured human retinal pigment epithelium cells. Experimental eye research. vol 147. 2017-05-25. PMID:27130547. |
moreover, ma treatment decreased apoptotic cells, ros and bax and increased △Ψ m and bcl2 in hrpe cells under serum withdrawal-induced apoptosis. |
2017-05-25 |
2023-08-13 |
human |
| Ntube N O Ngalame, Ngome L Makia, Michael P Waalkes, Erik J Toka. Mitigation of arsenic-induced acquired cancer phenotype in prostate cancer stem cells by miR-143 restoration. Toxicology and applied pharmacology. vol 312. 2017-05-23. PMID:26721309. |
increased apoptosis was associated with decreased bcl2 and bcl-xl expression. |
2017-05-23 |
2023-08-13 |
human |
| M A Crookenden, A Heiser, A Murray, V S R Dukkipati, J K Kay, J J Loor, S Meier, M D Mitchell, K M Moyes, C G Walker, J R Roch. Parturition in dairy cows temporarily alters the expression of genes in circulating neutrophils. Journal of dairy science. vol 99. issue 8. 2017-05-12. PMID:27179873. |
genes that were differentially expressed over the transition period included those involved in neutrophil adhesion (sell, itgb2, and itgbx), mediation of the immune response (tlr4, hla-dra, and cxcr2), maturation, cell cycle progression, apoptosis (mcl1, bcl2, faslg, and ripk1), and control of gene expression (pparg, ppard, and stat3). |
2017-05-12 |
2023-08-13 |
Not clear |
| Supriya V Vartak, Mahesh Hegde, Divyaanka Iyer, Snehal Gaikwad, Vidya Gopalakrishnan, Mrinal Srivastava, Subhas S Karki, Bibha Choudhary, Pritha Ray, T R Santhoshkumar, Sathees C Raghava. A novel inhibitor of BCL2, Disarib abrogates tumor growth while sparing platelets, by activating intrinsic pathway of apoptosis. Biochemical pharmacology. vol 122. 2017-05-09. PMID:27693384. |
a novel inhibitor of bcl2, disarib abrogates tumor growth while sparing platelets, by activating intrinsic pathway of apoptosis. |
2017-05-09 |
2023-08-13 |
mouse |
| Rabia Johnson, Phiwayinkosi V Dludla, Christo J F Muller, Barbara Huisamen, M Faadiel Essop, Johan Lou. The Transcription Profile Unveils the Cardioprotective Effect of Aspalathin against Lipid Toxicity in an In Vitro H9c2 Model. Molecules (Basel, Switzerland). vol 22. issue 2. 2017-05-09. PMID:28146135. |
aspalathin was able to modulate key regulators associated with lipid metabolism (adipoq, apob, cd36, cpt1, pparγ, srebf1/2, scd1 and vldlr), insulin resistance (igf1, akt1, pde3 and map2k1), inflammation (il3, il6, jak2, lepr, socs3, and tnf13) and apoptosis (bcl2 and chuk). |
2017-05-09 |
2023-08-13 |
Not clear |
| Rabia Johnson, Phiwayinkosi V Dludla, Christo J F Muller, Barbara Huisamen, M Faadiel Essop, Johan Lou. The Transcription Profile Unveils the Cardioprotective Effect of Aspalathin against Lipid Toxicity in an In Vitro H9c2 Model. Molecules (Basel, Switzerland). vol 22. issue 2. 2017-05-09. PMID:28146135. |
collectively, our results suggest that aspalathin could reverse metabolic abnormalities by activating adipoq while modulating the expression of pparγ and srebf1/2, decreasing inflammation via il6/jak2 pathway, which together with an observed increased expression of bcl2 prevents myocardium apoptosis. |
2017-05-09 |
2023-08-13 |
Not clear |
| Samira Hajiaghalou, Bita Ebrahimi, Abdolhossein Shahverdi, Mina Sharbatoghli, Nasim Beigi Boroujen. Comparison of apoptosis pathway following the use of two protocols for vitrification of immature mouse testicular tissue. Theriogenology. vol 86. issue 8. 2017-05-08. PMID:27492762. |
morphology, cell viability, apoptosis incidence, and apoptosis gene expression (bax, bcl2, caspase 3, fas, fas ligand, p53) were evaluated at 0, 3, and 20 hours of culture by light microscopy, flow cytometry, and real-time polymerase chain reaction, respectively. |
2017-05-08 |
2023-08-13 |
mouse |
| Yogesh M Kulkarni, Vivek Kaushik, Neelam Azad, Clayton Wright, Yon Rojanasakul, George O'Doherty, Anand Krishnan V Iye. Autophagy-Induced Apoptosis in Lung Cancer Cells by a Novel Digitoxin Analog. Journal of cellular physiology. vol 231. issue 4. 2017-05-01. PMID:26264876. |
we investigated monod-dependent regulation of akt and bcl2, proteins that are known regulators of both autophagy and apoptosis. |
2017-05-01 |
2023-08-13 |
Not clear |
| Yanping Zhu, Yanxia Fu, Hairong Li. Baicalin Inhibits Renal Cell Apoptosis and Protects Against Acute Kidney Injury in Pediatric Sepsis. Medical science monitor : international medical journal of experimental and clinical research. vol 22. 2017-04-28. PMID:28013315. |
mouse sepsis models were constructed by cecal ligation and puncture (clp) and treated with baicalin intragastrically, after which bun and cr examination, tunel apoptosis assay, and expression analyses of bax and bcl2 were performed. |
2017-04-28 |
2023-08-13 |
mouse |
| Yanping Zhu, Yanxia Fu, Hairong Li. Baicalin Inhibits Renal Cell Apoptosis and Protects Against Acute Kidney Injury in Pediatric Sepsis. Medical science monitor : international medical journal of experimental and clinical research. vol 22. 2017-04-28. PMID:28013315. |
it inhibited bax and promoted bcl2 in the renal tissue, which was consistent with cell apoptosis changes. |
2017-04-28 |
2023-08-13 |
mouse |
| Ulrike B Hendgen-Cotta, Sonja Esfeld, Katharina Rudi, Ilkka Miinalainen, Johann P Klare, Tienush Rassa. Cytosolic BNIP3 Dimer Interacts with Mitochondrial BAX Forming Heterodimers in the Mitochondrial Outer Membrane under Basal Conditions. International journal of molecular sciences. vol 18. issue 4. 2017-04-28. PMID:28333095. |
we investigated the basal distribution of cardiac bnip3 in vivo and its physical interaction with the pro-death protein bcl2 associated x, apoptosis regulator (bax) and with mitochondria using immunoblot analysis, co-immunoprecipitation, and continuous wave and pulsed electron paramagnetic resonance spectroscopy techniques. |
2017-04-28 |
2023-08-13 |
Not clear |
| Qi Jiang, Qingwei Li, Jianmei Han, Meng Gou, Yuanyuan Zheng, Bowen Li, Rong Xiao, Jihong Wan. rLj-RGD3 induces apoptosis via the mitochondrial-dependent pathway and inhibits adhesion, migration and invasion of human HeyA8 cells via FAK pathway. International journal of biological macromolecules. vol 96. 2017-04-17. PMID:28038913. |
according to the confocal microscope, flow cytometry and western blot analysis, rlj-rgd3 could trigger heya8 cells apoptosis by changing mitochondrial membrane potential, arrangement of f-actin, protein level of bcl2, bax, caspase 3, and cleaved caspase 3, concentration of cytoplasmic calcium, as well as phosphorylation level of erk/jnk/p38. |
2017-04-17 |
2023-08-13 |
human |
| Su-Jin Cho, Kyeong-Lim Lee, Yu-Gon Kim, Dong-Hoon Kim, Jae-Gyu Yoo, Byoung-Chul Yang, Jin-Ki Park, Il-Keun Kon. Differential gene-expression profiles from canine cumulus cells of ovulated versus in vitro-matured oocytes. Reproduction, fertility, and development. vol 28. issue 3. 2017-04-10. PMID:25004936. |
genes analysed are related to cell maturation, development and apoptosis, including gdf9, mapk1, ptx3, cx43, bcl2 and bax; mrna expression for all of these genes, except for gdf9, differed (p<0.05) between in vivo- and in vitro-matured ccs. |
2017-04-10 |
2023-08-13 |
Not clear |
| Guangxian Zhang, Xiancheng Zeng, Ren Zhang, Juan Liu, Weici Zhang, Yujun Zhao, Xiaoyuan Zhang, Zhixue Wu, Yuhui Tan, Yingya Wu, Biaoyan D. Dioscin suppresses hepatocellular carcinoma tumor growth by inducing apoptosis and regulation of TP53, BAX, BCL2 and cleaved CASP3. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 23. issue 12. 2017-04-07. PMID:27765352. |
dioscin suppresses hepatocellular carcinoma tumor growth by inducing apoptosis and regulation of tp53, bax, bcl2 and cleaved casp3. |
2017-04-07 |
2023-08-13 |
Not clear |
| Yan Li, Tao Yang, Jing Li, Hong-Ling Hao, Su-Yun Wang, Jie Yang, Jian-Min Lu. Inhibition of multiple myeloma cell proliferation by ginsenoside Rg3 via reduction in the secretion of IGF-1. Molecular medicine reports. vol 14. issue 3. 2017-04-06. PMID:27430248. |
furthermore, rg3 induced multiple myeloma cell apoptosis, and was involved in b cell lymphoma-2 (bcl2)/bcl2-associated x protein imbalance, caspase activation and the release of cytochrome c from the mitochondria into the cytoplasm. |
2017-04-06 |
2023-08-13 |
human |
| Tao Lin, Jae Eun Lee, Reza K Oqani, So Yeon Kim, Eun Seok Cho, Yong Dae Jeong, Jun Jong Baek, Dong Il Ji. Tauroursodeoxycholic acid improves pre-implantation development of porcine SCNT embryo by endoplasmic reticulum stress inhibition. Reproductive biology. vol 16. issue 4. 2017-04-06. PMID:27765486. |
tunel assay showed that tudca treatment significantly reduced apoptosis in porcine scnt blastocysts confirmed by decreased pro-apoptotic bax and increased anti-apoptotic bcl2 mrna levels. |
2017-04-06 |
2023-08-13 |
Not clear |
| Nerea Rebolleda, Ignacio Losada-Fernandez, Gema Perez-Chacon, Raquel Castejon, Silvia Rosado, Marta Morado, Maria Teresa Vallejo-Cremades, Andrea Martinez, Juan A Vargas-Nuñez, Paloma Perez-Acieg. Synergistic Activity of Deguelin and Fludarabine in Cells from Chronic Lymphocytic Leukemia Patients and in the New Zealand Black Murine Model. PloS one. vol 11. issue 4. 2017-04-05. PMID:27101369. |
in both of them, deguelin dowregulates akt, nfκb and several downstream antiapoptotic proteins (xiap, ciap, bcl2, bcl-xl and survivin), activating the mitochondrial pathway of apoptosis. |
2017-04-05 |
2023-08-13 |
mouse |
| Maryam Jalayeri, Afshin Pirnia, Elaheh Poorazizi Najafabad, Ali Mohammad Varzi, Mohammadreza Gholam. Evaluation of alginate hydrogel cytotoxicity on three-dimensional culture of type A spermatogonial stem cells. International journal of biological macromolecules. vol 95. 2017-04-05. PMID:27984148. |
after one month of encapsulation and culture in dmem culture medium containing 10ng/ml gdnf, cells were removed from hydrogel and were examined for viability, cell morphology and structure, cytotoxicity and expression of apoptosis genes fas, p53, bax, bcl2, caspase3 by staining with trypan blue, scanning electron microscopy, ldh test, and real time pcr, respectively. |
2017-04-05 |
2023-08-13 |
mouse |
| Magdalena Dziegala, Monika Kasztura, Kamil Kobak, Jacek Bania, Waldemar Banasiak, Piotr Ponikowski, Ewa A Jankowsk. Influence of the availability of iron during hypoxia on the genes associated with apoptotic activity and local iron metabolism in rat H9C2 cardiomyocytes and L6G8C5 skeletal myocytes. Molecular medicine reports. vol 14. issue 4. 2017-04-04. PMID:27599775. |
the mrna expression levels of markers of apoptosis [b‑cell lymphoma‑2 (bcl2; inhibition) and bcl‑2‑activated x protein (bax; induction)], atrophy (atrogin), glycolysis (pyruvate kinase 2; pkm2) and iron metabolism [transferrin receptor 1 (tfr1; iron importer), ferroportin 1 (fpn1; iron exporter), ferritin heavy chain (fth; iron storage protein) and hepcidin (hamp; iron regulator)] were determined using reverse transcription‑quantitative polymerase chain reaction, and cell viability was measured using an tetrazolium reduction assay. |
2017-04-04 |
2023-08-13 |
rat |