| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| María Hernández-Sánchez, Ana E Rodríguez-Vicente, José-Ángel Hernández, Eva Lumbreras, María-Eugenia Sarasquete, Ana-África Martín, Rocío Benito, Carlos Vicente-Gutiérrez, Cristina Robledo, Natalia de Las Heras, Juan-Nicolás Rodríguez, Miguel Alcoceba, Alfonso García de Coca, Carlos Aguilar, Marcos González, Jesús-María Hernández-Riva. MiRNA expression profile of chronic lymphocytic leukemia patients with 13q deletion. Leukemia research. vol 46. 2017-07-17. PMID:27111859. |
this deregulation affected important validated target genes involved in apoptosis (bcl2, mdm2, tp53inp1) and proliferation (kras, pi3k-akt signaling), that could lead to decreased apoptosis and increased proliferation in 13q-h patients. |
2017-07-17 |
2023-08-13 |
Not clear |
| Fei Liu, Wei-Lin Zhang, Hong-Zheng Meng, Zheng-Yu Cai, Mao-Wei Yan. Regulation of DMT1 on autophagy and apoptosis in osteoblast. International journal of medical sciences. vol 14. issue 3. 2017-07-17. PMID:28367088. |
apoptosis was evaluated by detecting the levels of cleaved caspase 3, bcl2, and bax with western blotting. |
2017-07-17 |
2023-08-13 |
Not clear |
| Amanda L Patchett, Jocelyn M Darby, Cesar Tovar, A Bruce Lyons, Gregory M Wood. The Immunomodulatory Small Molecule Imiquimod Induces Apoptosis in Devil Facial Tumour Cell Lines. PloS one. vol 11. issue 12. 2017-07-11. PMID:27936237. |
induction of apoptosis was accompanied by down-regulation of the anti-apoptotic bcl2 and bclxl genes, and up-regulation of the pro-apoptotic bim gene. |
2017-07-11 |
2023-08-13 |
human |
| Sahar El-Sayed Elswefy, Fatma Rizk Abdallah, Hebatallah Husseini Atteia, Alaa Samir Wahba, Rehab Abdallah Hasa. Inflammation, oxidative stress and apoptosis cascade implications in bisphenol A-induced liver fibrosis in male rats. International journal of experimental pathology. vol 97. issue 5. 2017-07-10. PMID:27925325. |
in addition, there was inflammation (as reflected in increase in interleukin-1beta 'il-1β', decrease in interleukin-10 'il-10' serum levels and increase in il-1β/il-10 ratio), oxidative stress (as reflected in increase in malondialdehyde (mda) level, reduction in reduced glutathione (gsh) content and inhibition of catalase (cat) activity) and apoptosis [as reflected in an increase in caspase-3 level and a decrease in numbers of b-cell lymphoma 2 (bcl2)-immunopositive hepatocytes]. |
2017-07-10 |
2023-08-13 |
rat |
| Khushboo Singh, James M Brigg. Functional Implications of the spectrum of BCL2 mutations in Lymphoma. Mutation research. Reviews in mutation research. vol 769. 2017-07-03. PMID:27543313. |
bcl2 arbitrates apoptosis through a classic interaction between its hydrophobic groove forming bh1-3 domains and the bh3 domain of pro-apoptotic members of the bcl2 family. |
2017-07-03 |
2023-08-13 |
Not clear |
| Khushboo Singh, James M Brigg. Functional Implications of the spectrum of BCL2 mutations in Lymphoma. Mutation research. Reviews in mutation research. vol 769. 2017-07-03. PMID:27543313. |
the effects of mutations are mainly determined by the ability of the mutated bcl2 to mediate apoptosis by this inter-member protein binding. |
2017-07-03 |
2023-08-13 |
Not clear |
| Ryan S Soderquist, Alan Eastma. BCL2 Inhibitors as Anticancer Drugs: A Plethora of Misleading BH3 Mimetics. Molecular cancer therapeutics. vol 15. issue 9. 2017-06-29. PMID:27535975. |
hence, bcl2 inhibitors have been developed as direct inducers of apoptosis. |
2017-06-29 |
2023-08-13 |
Not clear |
| Ryan S Soderquist, Alan Eastma. BCL2 Inhibitors as Anticancer Drugs: A Plethora of Misleading BH3 Mimetics. Molecular cancer therapeutics. vol 15. issue 9. 2017-06-29. PMID:27535975. |
a true bcl2 inhibitor will rapidly induce apoptosis in chronic lymphocytic leukemia cells ex vivo a bclxl inhibitor will rapidly induce apoptosis in platelets. |
2017-06-29 |
2023-08-13 |
Not clear |
| Shao-Ze Wu, Lu-Yuan Tao, Jiao-Ni Wang, Zhi-Qiang Xu, Jie Wang, Yang-Jing Xue, Kai-Yu Huang, Jia-Feng Lin, Lei Li, Kang-Ting J. Amifostine Pretreatment Attenuates Myocardial Ischemia/Reperfusion Injury by Inhibiting Apoptosis and Oxidative Stress. Oxidative medicine and cellular longevity. vol 2017. 2017-06-21. PMID:28392886. |
in vivo, amifostine pretreatment alleviated i/r injury and decreased myocardial apoptosis and infarct area, which was paralleled by increased superoxide dismutase (sod) and reduced malondialdehyde (mda) in myocardial tissues, increased bcl2 expression, decreased bax expression, lower cleaved caspase-3 level, fewer tunel positive cells, and fewer dhe-positive cells in heart. |
2017-06-21 |
2023-08-13 |
mouse |
| Jia-Hong Wang, Lan Zhao, Xin Pan, Nan-Nan Chen, Jian Chen, Qun-Lin Gong, Feng Su, Jian Yan, Yan Zhang, Shao-Heng Zhan. Hypoxia-stimulated cardiac fibroblast production of IL-6 promotes myocardial fibrosis via the TGF-β1 signaling pathway. Laboratory investigation; a journal of technical methods and pathology. vol 96. issue 8. 2017-06-19. PMID:27348628. |
in addition, il-6 activated the apoptosis-associated factors caspase3 and smad3, and decreased the expression of anti-apoptotic factor bcl2, resulting in apoptosis of cms under hypoxic coculture: il6ri or tβri inhibited these effects. |
2017-06-19 |
2023-08-13 |
rat |
| Yuan Yang, Yi Xie, Mengyun Wu, Yanqing Geng, Rong Li, Lei Xu, Xueqing Liu, Yongquan Pa. Expression of mmu-miR-96 in the endometrium during early pregnancy and its regulatory effects on stromal cell apoptosis via Bcl2. Molecular medicine reports. vol 15. issue 4. 2017-06-19. PMID:28259902. |
expression of mmu-mir-96 in the endometrium during early pregnancy and its regulatory effects on stromal cell apoptosis via bcl2. |
2017-06-19 |
2023-08-13 |
mouse |
| Sun-A Ock, Yeon-Mi Lee, Ji-Sung Park, Sharath Belame Shivakumar, Seon-Woung Moon, Nak-Ju Sung, Won-Jae Lee, Si-Jung Jang, Ju-Mi Park, Seung-Chan Lee, Sung-Lim Lee, Gyu-Jin Rh. Evaluation of phenotypic, functional and molecular characteristics of porcine mesenchymal stromal/stem cells depending on donor age, gender and tissue source. The Journal of veterinary medical science. vol 78. issue 6. 2017-06-15. PMID:26922917. |
mscs were analyzed for alkaline phosphatase (ap) activity, cd90 and oct3/4 expression, in vitro differentiation ability, senescence-associated β-galactosidase (sa-β-gal) activity, telomeric properties, cell cycle status and expression of senescence (il6, c-myc, tgfβ, p53 and p21)- and apoptosis (bak and bcl2)-related proteins. |
2017-06-15 |
2023-08-13 |
Not clear |
| Alina Fedoseienko, Hylke W Wieringa, G Bea A Wisman, Evelien Duiker, Anna K L Reyners, Marten H Hofker, Ate G J van der Zee, Bart van de Sluis, Marcel A T M van Vug. Nuclear COMMD1 Is Associated with Cisplatin Sensitivity in Ovarian Cancer. PloS one. vol 11. issue 10. 2017-06-15. PMID:27788210. |
this was accompanied by a more effective g2/m checkpoint, and decreased protein expression of the dna repair gene brca1, and the apoptosis inhibitor bcl2. |
2017-06-15 |
2023-08-13 |
Not clear |
| Ji-Liang Zhang, Christopher Laurence Souders, Nancy D Denslow, Christopher J Martyniu. Quercetin, a natural product supplement, impairs mitochondrial bioenergetics and locomotor behavior in larval zebrafish (Danio rerio). Toxicology and applied pharmacology. vol 327. 2017-06-13. PMID:28450151. |
there were no changes in transcripts related to apoptosis (bcl2, bax, casp3, casp7), but we did observe a decrease in mrna levels for catalase (cat) in fish exposed to each dose, supporting an oxidative stress response. |
2017-06-13 |
2023-08-13 |
cat |
| Xiaomin Zhong, Lan Zheng, Jianfeng Shen, Dongmei Zhang, Minmin Xiong, Youyou Zhang, Xinhong He, Janos L Tanyi, Feng Yang, Kathleen T Montone, Xiaojun Chen, Congjian Xu, Andy P Xiang, Qihong Huang, Xiaowei Xu, Lin Zhan. Suppression of MicroRNA 200 Family Expression by Oncogenic KRAS Activation Promotes Cell Survival and Epithelial-Mesenchymal Transition in KRAS-Driven Cancer. Molecular and cellular biology. vol 36. issue 21. 2017-06-12. PMID:27550813. |
restoration of mir-200 expression compromised kras-induced cellular transformation in vitro and tumor formation in vivo in addition, we found that enforced expression of mir-200 abrogated kras-induced resistance to apoptosis by directly targeting the antiapoptotic gene bcl2 finally, mir-200 was able to antagonize the epithelial-mesenchymal transition (emt) driven by mutant kras. |
2017-06-12 |
2023-08-13 |
human |
| Federica Rizzo, Dario Ronchi, Sabrina Salani, Monica Nizzardo, Francesco Fortunato, Andreina Bordoni, Giulia Stuppia, Roberto Del Bo, Daniela Piga, Romana Fato, Nereo Bresolin, Giacomo P Comi, Stefania Cort. Selective mitochondrial depletion, apoptosis resistance, and increased mitophagy in human Charcot-Marie-Tooth 2A motor neurons. Human molecular genetics. vol 25. issue 19. 2017-06-09. PMID:27506976. |
p53, bax, caspase 8, cleaved caspase 3, and the anti-apoptotic marker bcl2) demonstrated that cmt2a-mns are more resistant to apoptosis than wild-type mns. |
2017-06-09 |
2023-08-13 |
human |
| Stephan Stilgenbauer, Barbara Eichhorst, Johannes Schetelig, Steven Coutre, John F Seymour, Talha Munir, Soham D Puvvada, Clemens-Martin Wendtner, Andrew W Roberts, Wojciech Jurczak, Stephen P Mulligan, Sebastian Böttcher, Mehrdad Mobasher, Ming Zhu, Monali Desai, Brenda Chyla, Maria Verdugo, Sari Heitner Enschede, Elisa Cerri, Rod Humerickhouse, Gary Gordon, Michael Hallek, William G Wierd. Venetoclax in relapsed or refractory chronic lymphocytic leukaemia with 17p deletion: a multicentre, open-label, phase 2 study. The Lancet. Oncology. vol 17. issue 6. 2017-06-05. PMID:27178240. |
venetoclax is an oral small-molecule bcl2 inhibitor that induces chronic lymphocytic leukaemia cell apoptosis. |
2017-06-05 |
2023-08-13 |
Not clear |
| Selma Tuzlak, Thomas Kaufmann, Andreas Villunge. Interrogating the relevance of mitochondrial apoptosis for vertebrate development and postnatal tissue homeostasis. Genes & development. vol 30. issue 19. 2017-06-05. PMID:27798841. |
many of these studies were geared toward understanding the role of bcl2 family proteins and mitochondrial apoptosis in disease, whereas fewer focused in detail on their role during normal development or tissue homeostasis, perhaps also due to an irritating lack of phenotype. |
2017-06-05 |
2023-08-13 |
mouse |
| Liza J Burton, Mariela Rivera, Ohuod Hawsawi, Jin Zou, Tamaro Hudson, Guangdi Wang, Qiang Zhang, Luis Cubano, Nawal Boukli, Valerie Odero-Mara. Muscadine Grape Skin Extract Induces an Unfolded Protein Response-Mediated Autophagy in Prostate Cancer Cells: A TMT-Based Quantitative Proteomic Analysis. PloS one. vol 11. issue 10. 2017-05-31. PMID:27755556. |
the up-regulation of pro-apoptotic markers parp, caspase-12, cleaved caspase-3, -7, bax and down-regulation of anti-apoptotic marker bcl2 was confirmed by western blot analysis and apoptosis was visualized by increased tunel/annexin v staining upon mske treatment. |
2017-05-31 |
2023-08-13 |
Not clear |
| Supriya V Vartak, Divyaanka Iyer, T R Santhoshkumar, Sheetal Sharma, Archita Mishra, Gunaseelan Goldsmith, Mrinal Srivastava, Shikha Srivastava, Subhas S Karki, Avadhesha Surolia, Bibha Choudhary, Sathees C Raghava. Novel BCL2 inhibitor, Disarib induces apoptosis by disruption of BCL2-BAK interaction. Biochemical pharmacology. vol 131. 2017-05-29. PMID:28223017. |
novel bcl2 inhibitor, disarib induces apoptosis by disruption of bcl2-bak interaction. |
2017-05-29 |
2023-08-13 |
Not clear |