| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maoxi Liu, Zhongxue Fu, Xingye Wu, Kunli Du, Shouru Zhang, Li Zen. Inhibition of phospholipaseD2 increases hypoxia-induced human colon cancer cell apoptosis through inactivating of the PI3K/AKT signaling pathway. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 5. 2017-03-10. PMID:26614430. |
furthermore, interference the pld2 gene expression leaded to the apoptosis of hypoxic colon cancer cells increased and also decreased the expression level of survivin and bcl2 may through inactivation of pi3k/akt signaling pathway. |
2017-03-10 |
2023-08-13 |
human |
| Wuhao Lu, Long Feng, Yan Zhang, Yunyun Ma, Ping Li, Yuanyuan Wang, Yuwen Du, Xiaonan Chen, Shujun Wu, Guoqiang Zhao, Weihua Lo. miR-15a induces cell apoptosis by targeting BCL2L2 and BCL2 in HPV-positive hypopharyngeal squamous cell carcinoma. Oncology reports. vol 36. issue 4. 2017-03-10. PMID:27573302. |
mir-15a induces cell apoptosis by targeting bcl2l2 and bcl2 in hpv-positive hypopharyngeal squamous cell carcinoma. |
2017-03-10 |
2023-08-13 |
Not clear |
| Wuhao Lu, Long Feng, Yan Zhang, Yunyun Ma, Ping Li, Yuanyuan Wang, Yuwen Du, Xiaonan Chen, Shujun Wu, Guoqiang Zhao, Weihua Lo. miR-15a induces cell apoptosis by targeting BCL2L2 and BCL2 in HPV-positive hypopharyngeal squamous cell carcinoma. Oncology reports. vol 36. issue 4. 2017-03-10. PMID:27573302. |
after transfection, overexpression of mir-15a in the fadu cells was associated with significantly decreased bcl2l2 and bcl2 expression and a significant increase in the apoptosis rate. |
2017-03-10 |
2023-08-13 |
Not clear |
| Cristiane Oliveira, Gustavo Jacob Lourenço, José Augusto Rinck-Junior, Aparecida Machado de Moraes, Carmen Silvia Passos Lim. Polymorphisms in apoptosis-related genes in cutaneous melanoma prognosis: sex disparity. Medical oncology (Northwood, London, England). vol 34. issue 2. 2017-03-08. PMID:28050764. |
cutaneous melanoma (cm) cells are resistant to apoptosis, and steroid hormones are involved in this process through regulation of tp53, mdm2, bax, and bcl2 expression. |
2017-03-08 |
2023-08-13 |
Not clear |
| Cristiane Oliveira, Gustavo Jacob Lourenço, José Augusto Rinck-Junior, Aparecida Machado de Moraes, Carmen Silvia Passos Lim. Polymorphisms in apoptosis-related genes in cutaneous melanoma prognosis: sex disparity. Medical oncology (Northwood, London, England). vol 34. issue 2. 2017-03-08. PMID:28050764. |
our data present, for the first time, preliminary evidence that inherited abnormalities on tp53, mdm2 and bcl2 genes, enrolled in apoptosis pathways, have a pivotal role in differences of outcomes in women and men with cm. |
2017-03-08 |
2023-08-13 |
Not clear |
| Wei Lu, Shu Ya Huang, Le Su, Bao Xiang Zhao, Jun Ying Mia. Long Noncoding RNA LOC100129973 Suppresses Apoptosis by Targeting miR-4707-5p and miR-4767 in Vascular Endothelial Cells. Scientific reports. vol 6. 2017-03-02. PMID:26887505. |
through sponging mir-4707-5p and mir-4767, lncrna loc100129973 upregulated the expression of two apoptosis repressors gene, apoptosis inhibitor 5 (api5) and bcl2 like 12 (bcl2l12), and thus alleviated the serum and fgf-2 starvation-induced apoptosis in vecs. |
2017-03-02 |
2023-08-13 |
Not clear |
| Moudan Lin, Tian Wu, Lingbin Sun, Jackie Jin Lin, Zhenghong Zuo, Chonggang Wan. Aroclor 1254 causes atrophy of exocrine pancreas in mice and the mechanism involved. Environmental toxicology. vol 31. issue 6. 2017-03-01. PMID:25409620. |
tunel-positive apoptotic cells as well as the expression of bcl2, bclxl, bax, and bad of exocrine pancreas did not show significant changes in the treated mice, indicating that aroclor 1254 has no effect on apoptosis. |
2017-03-01 |
2023-08-13 |
mouse |
| Zhengxing Xie, Ping Han, Zhenwen Cui, Baofeng Wang, Zhihong Zhong, Yuhao Sun, Guoyuan Yang, Qingfang Sun, Liuguan Bia. Pretreatment of Mouse Neural Stem Cells with Carbon Monoxide-Releasing Molecule-2 Interferes with NF-κB p65 Signaling and Suppresses Iron Overload-Induced Apoptosis. Cellular and molecular neurobiology. vol 36. issue 8. 2017-02-21. PMID:26961543. |
tunel staining showed that preconditioning c17.2 cells with corm-2 enhanced their resistance to apoptosis induced by iron overload, which was concomitant with down-regulation of the pro-apoptotic proteins (bax and cleaved caspase-3) and up-regulation of the anti-apoptotic protein bcl2. |
2017-02-21 |
2023-08-13 |
mouse |
| Rui Hu, Fengqing Hu, Xiao Xie, Lei Wang, Guoqing Li, Tong Qiao, Mingsong Wang, Haibo Xia. TMEM45B, up-regulated in human lung cancer, enhances tumorigenicity of lung cancer cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 9. 2017-02-21. PMID:27225290. |
moreover, knockdown of tmem45b significantly suppressed g1/s transition, induced cell apoptosis, and inhibited cell invasion via regulating the expression of cell cycle-related proteins (cdk2, cdc25a, and pcna), cell apoptosis-related proteins (bcl2, bax, and cleaved caspase 3), and metastasis-related proteins (mmp-9, twist, and snail), respectively. |
2017-02-21 |
2023-08-13 |
mouse |
| Patricia Morcillo, José Meseguer, M Ángeles Esteban, Alberto Cuest. In vitro effects of metals on isolated head-kidney and blood leucocytes of the teleost fish Sparus aurata L. and Dicentrarchus labrax L. Fish & shellfish immunology. vol 54. 2017-02-17. PMID:27041665. |
in addition, this profile leads to the increase of expression in genes related to apoptosis (bcl2 associated x protein and caspase 3). |
2017-02-17 |
2023-08-13 |
Not clear |
| M A Behdani, R Hoshya. Phytochemical properties of Iranian organic saffron stigma: antioxidant, anticancer and apoptotic approaches. Cellular and molecular biology (Noisy-le-Grand, France). vol 62. issue 14. 2017-02-16. PMID:28145859. |
herb-induced apoptosis associated with increased expression of bax and decreased bcl2 gene leading eventually to a time-dependent increase in bax/bcl-2 ratio. |
2017-02-16 |
2023-08-13 |
Not clear |
| Quanxin Gao, Qian Gao, Minghua Min, Chenjie Zhang, Shiming Peng, Zhaohong Sh. Ability of Lactobacillus plantarum lipoteichoic acid to inhibit Vibrio anguillarum-induced inflammation and apoptosis in silvery pomfret (Pampus argenteus) intestinal epithelial cells. Fish & shellfish immunology. vol 54. 2017-02-14. PMID:27179425. |
it also showed significant inhibitory effects on ehec-induced inflammation and apoptosis by modulating the expression of nf-κb (nuclear factor kappa b), iκb (inhibitor of nf-κb), bcl2 (b-cell leukemia/lymphoma-2), bax (bcl-2-associated x protein), il-8 (interleukin 8) and tnf-α (tumor necrosis factor-α), and via inhibition of caspase-9 and caspase-3 activation. |
2017-02-14 |
2023-08-13 |
Not clear |
| Sandip Kumar Rath, Moonmoon Deb, Dipta Sengupta, Vijayalaxmi Kari, Swayamsiddha Kar, Sabnam Parbin, Nibedita Pradhan, Samir Kumar Patr. Silencing of ZRF1 impedes survival of estrogen receptor positive MCF-7 cells and potentiates the effect of curcumin. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 9. 2017-02-14. PMID:27350366. |
moreover, the decrease in viability of mcf-7 cells was accompanied by induction of apoptosis and dna damage, well-marked with upregulation of cleaved parp and downregulation of bcl2 and h2aubk119 levels. |
2017-02-14 |
2023-08-13 |
Not clear |
| Verónica Bastos, José M P Ferreira-de-Oliveira, Joana Carrola, Ana L Daniel-da-Silva, Iola F Duarte, Conceição Santos, Helena Oliveir. Coating independent cytotoxicity of citrate- and PEG-coated silver nanoparticles on a human hepatoma cell line. Journal of environmental sciences (China). vol 51. 2017-02-09. PMID:28115130. |
at the concentrations used (11 and 5μg/ml corresponding to ic50 and ~ic10 levels, respectively) the amount of cells undergoing apoptosis was not significant and the apoptotic related genes bcl2 (anti-apoptotic gene) and bax (pro-apoptotic gene) were both downregulated. |
2017-02-09 |
2023-08-13 |
human |
| Andrew W Robert. Targeting apoptotic pathways to treat lymphoid malignancies. [Rinsho ketsueki] The Japanese journal of clinical hematology. vol 57. issue 10. 2017-02-08. PMID:27795514. |
consequently, many haematological malignancies also harbour aberrations that circumvent apoptosis, with aberrations of tp53 and the bcl2 family being the most common. |
2017-02-08 |
2023-08-13 |
Not clear |
| Andrew W Robert. Targeting apoptotic pathways to treat lymphoid malignancies. [Rinsho ketsueki] The Japanese journal of clinical hematology. vol 57. issue 10. 2017-02-08. PMID:27795514. |
this educational lecture focuses on current understanding of the role of the intrinsic pathway to apoptosis in lymphoid cancers, its regulation by bcl2 and related proteins, and emerging data on the therapeutic potential of inhibiting bcl2 to induce apoptosis in bcl2-expressing b cell cancers. |
2017-02-08 |
2023-08-13 |
Not clear |
| Sadegh Lotfalah Moradi, Gita Eslami, Hossein Goudarzi, Zahra Hajishafieeha, Masoud Soleimani, Adel Mohammadzadeh, Abdolreza Ardeshirylajim. Role of Helicobacter pylori on cancer of human adipose-derived mesenchymal stem cells and metastasis of tumor cells-an in vitro study. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 3. 2017-02-07. PMID:26446460. |
our results demonstrated that h. pylori tries to improve the ha-mscs carcinogenic activities by overexpression of bcl2 gene as an anti-apoptosis agent against the p53 gene expression as main apoptosis agent. |
2017-02-07 |
2023-08-13 |
human |
| Lulu Bai, Yu Guo, Yue Du, Huaxin Wang, Zhiying Zhao, Yuhong Huang, Jianwu Tan. 47kDa isoform of Annexin A7 affecting the apoptosis of mouse hepatocarcinoma cells line. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 83. 2017-02-07. PMID:27551759. |
these results indicate that 47kda isoform of annexin a7 could associated with the apoptosis of hca-p cells through its interaction with bcl2. |
2017-02-07 |
2023-08-13 |
mouse |
| Manel Boussabbeh, Intidhar Ben Salem, Karima Rjiba-Touati, Chedy Bouyahya, Fadwa Neffati, Mohamed Fadhel Najjar, Hassen Bacha, Salwa Abid-Essef. The potential effect of patulin on mice bearing melanoma cells: an anti-tumour or carcinogenic effect? Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 5. 2017-02-06. PMID:26619846. |
this effect was evidenced by the activation of apoptosis which is supported by the increase in p53 and bax expressions, the downregulation of the protein levels of bcl2, and the increase in caspase-3 activity. |
2017-02-06 |
2023-08-13 |
mouse |
| Akram Sadeghirizi, Razieh Yazdanparast, Safiyeh Aghazade. Combating trastuzumab resistance by targeting thioredoxin-1/PTEN interaction. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 5. 2017-02-06. PMID:26662109. |
treatment of the cells with px-12 (5 μm) and trastuzumab (10 μg/ml) reduced cells viabilities, p-akt, and bcl2 levels while increasing the levels of reactive oxygen species (ros) and p-jnk with consequent higher levels of g1 arrest and apoptosis among the resistant cells compared to parental trastuzumab sensitive cells. |
2017-02-06 |
2023-08-13 |
human |