| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xin Cao, Ying Lu, Xianyu Zhang, Damian Kovalovsk. Zbtb1 Safeguards Genome Integrity and Prevents p53-Mediated Apoptosis in Proliferating Lymphoid Progenitors. Journal of immunology (Baltimore, Md. : 1950). vol 197. issue 4. 2017-08-02. PMID:27402700. |
increased p53-mediated apoptosis affected not only lymphoid but also myeloid development in competitive bone marrow chimeras, and prevention of apoptosis by transgenic bcl2 expression and p53 deficiency rescued lymphoid as well as myeloid development from zbtb1-mutant progenitors. |
2017-08-02 |
2023-08-13 |
Not clear |
| Tahereh Javaheri, Zahra Kazemi, Jan Pencik, Ha Tt Pham, Maximilian Kauer, Rahil Noorizadeh, Barbara Sax, Harini Nivarthi, Michaela Schlederer, Barbara Maurer, Maximillian Hofbauer, Dave Nt Aryee, Marc Wiedner, Eleni M Tomazou, Malcolm Logan, Christine Hartmann, Jan P Tuckermann, Lukas Kenner, Mario Mikula, Helmut Dolznig, Aykut Üren, Günther H Richter, Florian Grebien, Heinrich Kovar, Richard Morigg. Increased survival and cell cycle progression pathways are required for EWS/FLI1-induced malignant transformation. Cell death & disease. vol 7. issue 10. 2017-07-31. PMID:27735950. |
blocking apoptosis through enforced bcl2 family member expression in mscs promoted efficient and rapid sarcoma formation when transplanted to immunocompromised mice. |
2017-07-31 |
2023-08-13 |
mouse |
| Fara Brasó-Maristany, Simone Filosto, Steven Catchpole, Rebecca Marlow, Jelmar Quist, Erika Francesch-Domenech, Darren A Plumb, Leila Zakka, Patrycja Gazinska, Gianmaria Liccardi, Pascal Meier, Albert Gris-Oliver, Maggie Chon U Cheang, Anna Perdrix-Rosell, Manar Shafat, Elodie Noël, Nirmesh Patel, Kristen McEachern, Maurizio Scaltriti, Pau Castel, Farzana Noor, Richard Buus, Sumi Mathew, Johnathan Watkins, Violeta Serra, Pierfrancesco Marra, Anita Grigoriadis, Andrew N Tut. PIM1 kinase regulates cell death, tumor growth and chemotherapy response in triple-negative breast cancer. Nature medicine. vol 22. issue 11. 2017-07-31. PMID:27775704. |
pim1 knockdown reduced expression of the anti-apoptotic factor bcl2, and dynamic bh3 profiling of apoptotic priming revealed that pim1 prevents mitochondrial-mediated apoptosis in tnbc cell lines. |
2017-07-31 |
2023-08-13 |
Not clear |
| Viswanath Gunda, Kristopher A Sarosiek, Eran Brauner, Yon Seon Kim, Salma Amin, Zhiheng Zhou, Antony Letai, Sareh Parang. Inhibition of MAPKinase pathway sensitizes thyroid cancer cells to ABT-737 induced apoptosis. Cancer letters. vol 395. 2017-07-31. PMID:28259821. |
bcl2 family proteins play an important role in the resistance of thyroid cancer cells to apoptosis induced by chemotherapeutic drugs and targeted therapies. |
2017-07-31 |
2023-08-13 |
mouse |
| Viswanath Gunda, Kristopher A Sarosiek, Eran Brauner, Yon Seon Kim, Salma Amin, Zhiheng Zhou, Antony Letai, Sareh Parang. Inhibition of MAPKinase pathway sensitizes thyroid cancer cells to ABT-737 induced apoptosis. Cancer letters. vol 395. 2017-07-31. PMID:28259821. |
targeting bcl2 family proteins with the bh3 mimetic, abt-737, while simultaneously inhibiting erk pathway proteins with plx4720 and pd325901 was shown to induce significantly high apoptosis in the majority of cell lines (8505c, sw1736, hth7, bcpap) and moderate apoptosis in the tpc-1 cell line. |
2017-07-31 |
2023-08-13 |
mouse |
| Akinori Kawakami, David E Fishe. The master role of microphthalmia-associated transcription factor in melanocyte and melanoma biology. Laboratory investigation; a journal of technical methods and pathology. vol 97. issue 6. 2017-07-27. PMID:28263292. |
mitf regulates expression of numerous pigmentation genes to promote melanocyte differentiation, as well as fundamental genes for maintaining cell homeostasis, including genes encoding proteins involved in apoptosis (eg, bcl2) and the cell cycle (eg, cdk2). |
2017-07-27 |
2023-08-13 |
Not clear |
| Boon Chin Heng, Xin Ye, Yuan Liu, Waruna Lakmal Dissanayaka, Gary Shun Pan Cheung, Chengfei Zhan. Effects of Recombinant Overexpression of Bcl2 on the Proliferation, Apoptosis, and Osteogenic/Odontogenic Differentiation Potential of Dental Pulp Stem Cells. Journal of endodontics. vol 42. issue 4. 2017-07-26. PMID:26898562. |
effects of recombinant overexpression of bcl2 on the proliferation, apoptosis, and osteogenic/odontogenic differentiation potential of dental pulp stem cells. |
2017-07-26 |
2023-08-13 |
Not clear |
| Z Xu, P P Sharp, Y Yao, D Segal, C H Ang, S L Khaw, B J Aubrey, J Gong, G L Kelly, M J Herold, A Strasser, A W Roberts, W S Alexander, C J Burns, D C S Huang, S P Glase. BET inhibition represses miR17-92 to drive BIM-initiated apoptosis of normal and transformed hematopoietic cells. Leukemia. vol 30. issue 7. 2017-07-26. PMID:27055867. |
thus, our study strongly suggests that mutations that permit the evasion of apoptosis (for example, bcl2 overexpression, bim inactivation) are likely to blunt the activity of the bet bromodomain inhibitors and should be anticipated when therapy resistance develops. |
2017-07-26 |
2023-08-13 |
mouse |
| Xuan Li, Yan-Kui Wang, Zhi-Qiang Song, Zhi-Qiang Du, Cai-Xia Yan. Dimethyl Sulfoxide Perturbs Cell Cycle Progression and Spindle Organization in Porcine Meiotic Oocytes. PloS one. vol 11. issue 6. 2017-07-24. PMID:27348312. |
3% dmso treatment did not affect expression of genes involved in spindle organization (bub1 and mad2) and apoptosis (nf-κb, pten, bcl2, caspase3 and caspase9), however, it significantly decreased expression levels of pluripotency genes (oct4, sox2 and lin28) in mature oocytes. |
2017-07-24 |
2023-08-13 |
mouse |
| María Hernández-Sánchez, Ana E Rodríguez-Vicente, José-Ángel Hernández, Eva Lumbreras, María-Eugenia Sarasquete, Ana-África Martín, Rocío Benito, Carlos Vicente-Gutiérrez, Cristina Robledo, Natalia de Las Heras, Juan-Nicolás Rodríguez, Miguel Alcoceba, Alfonso García de Coca, Carlos Aguilar, Marcos González, Jesús-María Hernández-Riva. MiRNA expression profile of chronic lymphocytic leukemia patients with 13q deletion. Leukemia research. vol 46. 2017-07-17. PMID:27111859. |
this deregulation affected important validated target genes involved in apoptosis (bcl2, mdm2, tp53inp1) and proliferation (kras, pi3k-akt signaling), that could lead to decreased apoptosis and increased proliferation in 13q-h patients. |
2017-07-17 |
2023-08-13 |
Not clear |
| Fei Liu, Wei-Lin Zhang, Hong-Zheng Meng, Zheng-Yu Cai, Mao-Wei Yan. Regulation of DMT1 on autophagy and apoptosis in osteoblast. International journal of medical sciences. vol 14. issue 3. 2017-07-17. PMID:28367088. |
apoptosis was evaluated by detecting the levels of cleaved caspase 3, bcl2, and bax with western blotting. |
2017-07-17 |
2023-08-13 |
Not clear |
| Amanda L Patchett, Jocelyn M Darby, Cesar Tovar, A Bruce Lyons, Gregory M Wood. The Immunomodulatory Small Molecule Imiquimod Induces Apoptosis in Devil Facial Tumour Cell Lines. PloS one. vol 11. issue 12. 2017-07-11. PMID:27936237. |
induction of apoptosis was accompanied by down-regulation of the anti-apoptotic bcl2 and bclxl genes, and up-regulation of the pro-apoptotic bim gene. |
2017-07-11 |
2023-08-13 |
human |
| Sahar El-Sayed Elswefy, Fatma Rizk Abdallah, Hebatallah Husseini Atteia, Alaa Samir Wahba, Rehab Abdallah Hasa. Inflammation, oxidative stress and apoptosis cascade implications in bisphenol A-induced liver fibrosis in male rats. International journal of experimental pathology. vol 97. issue 5. 2017-07-10. PMID:27925325. |
in addition, there was inflammation (as reflected in increase in interleukin-1beta 'il-1β', decrease in interleukin-10 'il-10' serum levels and increase in il-1β/il-10 ratio), oxidative stress (as reflected in increase in malondialdehyde (mda) level, reduction in reduced glutathione (gsh) content and inhibition of catalase (cat) activity) and apoptosis [as reflected in an increase in caspase-3 level and a decrease in numbers of b-cell lymphoma 2 (bcl2)-immunopositive hepatocytes]. |
2017-07-10 |
2023-08-13 |
rat |
| Khushboo Singh, James M Brigg. Functional Implications of the spectrum of BCL2 mutations in Lymphoma. Mutation research. Reviews in mutation research. vol 769. 2017-07-03. PMID:27543313. |
bcl2 arbitrates apoptosis through a classic interaction between its hydrophobic groove forming bh1-3 domains and the bh3 domain of pro-apoptotic members of the bcl2 family. |
2017-07-03 |
2023-08-13 |
Not clear |
| Khushboo Singh, James M Brigg. Functional Implications of the spectrum of BCL2 mutations in Lymphoma. Mutation research. Reviews in mutation research. vol 769. 2017-07-03. PMID:27543313. |
the effects of mutations are mainly determined by the ability of the mutated bcl2 to mediate apoptosis by this inter-member protein binding. |
2017-07-03 |
2023-08-13 |
Not clear |
| Ryan S Soderquist, Alan Eastma. BCL2 Inhibitors as Anticancer Drugs: A Plethora of Misleading BH3 Mimetics. Molecular cancer therapeutics. vol 15. issue 9. 2017-06-29. PMID:27535975. |
hence, bcl2 inhibitors have been developed as direct inducers of apoptosis. |
2017-06-29 |
2023-08-13 |
Not clear |
| Ryan S Soderquist, Alan Eastma. BCL2 Inhibitors as Anticancer Drugs: A Plethora of Misleading BH3 Mimetics. Molecular cancer therapeutics. vol 15. issue 9. 2017-06-29. PMID:27535975. |
a true bcl2 inhibitor will rapidly induce apoptosis in chronic lymphocytic leukemia cells ex vivo a bclxl inhibitor will rapidly induce apoptosis in platelets. |
2017-06-29 |
2023-08-13 |
Not clear |
| Shao-Ze Wu, Lu-Yuan Tao, Jiao-Ni Wang, Zhi-Qiang Xu, Jie Wang, Yang-Jing Xue, Kai-Yu Huang, Jia-Feng Lin, Lei Li, Kang-Ting J. Amifostine Pretreatment Attenuates Myocardial Ischemia/Reperfusion Injury by Inhibiting Apoptosis and Oxidative Stress. Oxidative medicine and cellular longevity. vol 2017. 2017-06-21. PMID:28392886. |
in vivo, amifostine pretreatment alleviated i/r injury and decreased myocardial apoptosis and infarct area, which was paralleled by increased superoxide dismutase (sod) and reduced malondialdehyde (mda) in myocardial tissues, increased bcl2 expression, decreased bax expression, lower cleaved caspase-3 level, fewer tunel positive cells, and fewer dhe-positive cells in heart. |
2017-06-21 |
2023-08-13 |
mouse |
| Jia-Hong Wang, Lan Zhao, Xin Pan, Nan-Nan Chen, Jian Chen, Qun-Lin Gong, Feng Su, Jian Yan, Yan Zhang, Shao-Heng Zhan. Hypoxia-stimulated cardiac fibroblast production of IL-6 promotes myocardial fibrosis via the TGF-β1 signaling pathway. Laboratory investigation; a journal of technical methods and pathology. vol 96. issue 8. 2017-06-19. PMID:27348628. |
in addition, il-6 activated the apoptosis-associated factors caspase3 and smad3, and decreased the expression of anti-apoptotic factor bcl2, resulting in apoptosis of cms under hypoxic coculture: il6ri or tβri inhibited these effects. |
2017-06-19 |
2023-08-13 |
rat |
| Yuan Yang, Yi Xie, Mengyun Wu, Yanqing Geng, Rong Li, Lei Xu, Xueqing Liu, Yongquan Pa. Expression of mmu-miR-96 in the endometrium during early pregnancy and its regulatory effects on stromal cell apoptosis via Bcl2. Molecular medicine reports. vol 15. issue 4. 2017-06-19. PMID:28259902. |
expression of mmu-mir-96 in the endometrium during early pregnancy and its regulatory effects on stromal cell apoptosis via bcl2. |
2017-06-19 |
2023-08-13 |
mouse |