| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zachary R Hunter, Guang Yang, Lian Xu, Xia Liu, Jorge J Castillo, Steven P Treo. Genomics, Signaling, and Treatment of Waldenström Macroglobulinemia. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. vol 35. issue 9. 2017-12-27. PMID:28294689. |
deletions involving chromosome 6q are common and include genes that modulate nuclear factor-κb, bcl2, btk, apoptosis, differentiation, and arid1b. |
2017-12-27 |
2023-08-13 |
Not clear |
| Mouna Tabebi, Bodour Khabou, Hanen Boukadi, Mariam Ben Hamad, Bochra Ben Rhouma, Slim Tounsi, Abdellatif Maalej, Hassen Kamoun, Leila Keskes-Ammar, Mohamed Abid, Mouna Mnif, Faiza Fakhfak. Association study of apoptosis gene polymorphisms in mitochondrial diabetes: A potential role in the pathogenicity of MD. Gene. vol 639. 2017-12-27. PMID:28987347. |
we found 10 selected polymorphisms (p53 (rs1042522 and rs17878362), bcl2 (rs2279115), bax (rs1805419), bak1 (rs210132 and rs2227925), casp3 (rs1405937), casp7 (rs2227310), casp8 (rs1045485) and casp10 (rs13006529)) with a potential apoptosis effect in md patients compared to control population. |
2017-12-27 |
2023-08-13 |
Not clear |
| Mouna Tabebi, Bodour Khabou, Hanen Boukadi, Mariam Ben Hamad, Bochra Ben Rhouma, Slim Tounsi, Abdellatif Maalej, Hassen Kamoun, Leila Keskes-Ammar, Mohamed Abid, Mouna Mnif, Faiza Fakhfak. Association study of apoptosis gene polymorphisms in mitochondrial diabetes: A potential role in the pathogenicity of MD. Gene. vol 639. 2017-12-27. PMID:28987347. |
specifically, snps involved in the intrinsic pathway (p53, bcl2, bak1 and casp3) presented the highest risk of apoptosis. |
2017-12-27 |
2023-08-13 |
Not clear |
| Bhawna Chandravanshi, Ramesh Ramchandra Bhond. Shielding Engineered Islets With Mesenchymal Stem Cells Enhance Survival Under Hypoxia. Journal of cellular biochemistry. vol 118. issue 9. 2017-12-26. PMID:28098405. |
this was further accompanied by reduction in total reactive oxygen species, nitric oxide, and super oxide ions and down regulation of caspase3, caspase8, p53, and up regulation of bcl2 confirming prevention of apoptosis in icas. |
2017-12-26 |
2023-08-13 |
Not clear |
| Carsten Utoft Nieman. [Targeted treatment of chronic lymphocytic leukaemia]. Ugeskrift for laeger. vol 176. issue 15. 2017-12-20. PMID:25350143. |
apoptosis induction by inhibition of bcl2 with abt-199 is reported with likewise promising clinical results. |
2017-12-20 |
2023-08-13 |
Not clear |
| Yan Xiu, Wingel Y Xue, Allyn Lambertz, Mariah Leidinger, Katherine Gibson-Corley, Chen Zha. Constitutive Activation of NIK Impairs the Self-Renewal of Hematopoietic Stem/Progenitor Cells and Induces Bone Marrow Failure. Stem cells (Dayton, Ohio). vol 35. issue 3. 2017-12-19. PMID:27733012. |
many genes (mpl, tifab, emcn, flt3, bcl2, and others) that regulate hspc self-renewal, lineage commitment, and apoptosis are significantly downregulated-and those genes that regulate inflammatory responses and cell cycle inhibition (cdkn2a and cdkn2b) are significantly upregulated-by activation of nik. |
2017-12-19 |
2023-08-13 |
Not clear |
| D Scarlet, N Ille, R Ertl, B G Alves, G D A Gastal, S O Paiva, M O Gastal, E L Gastal, C Auric. Glucocorticoid metabolism in equine follicles and oocytes. Domestic animal endocrinology. vol 59. 2017-12-19. PMID:27866059. |
in cumulus cells, messenger rna expression of genes involved in glucocorticoid mechanism and apoptosis was either increased (nr3c1 and bcl2) or decreased (hsd11b2) by treatment (p < 0.01). |
2017-12-19 |
2023-08-13 |
Not clear |
| Takeshi Moriishi, Ryo Fukuyama, Toshihiro Miyazaki, Tatsuya Furuichi, Masako Ito, Toshihisa Komor. Overexpression of BCLXL in Osteoblasts Inhibits Osteoblast Apoptosis and Increases Bone Volume and Strength. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 31. issue 7. 2017-12-15. PMID:26852895. |
the bcl2 family proteins, bcl2 and bclxl, suppress apoptosis by preventing the release of caspase activators from mitochondria through the inhibition of bax subfamily proteins. |
2017-12-15 |
2023-08-13 |
mouse |
| Takeshi Moriishi, Ryo Fukuyama, Toshihiro Miyazaki, Tatsuya Furuichi, Masako Ito, Toshihisa Komor. Overexpression of BCLXL in Osteoblasts Inhibits Osteoblast Apoptosis and Increases Bone Volume and Strength. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 31. issue 7. 2017-12-15. PMID:26852895. |
we reported that bcl2 overexpression in osteoblasts using the 2.3 kb col1a1 promoter increased osteoblast proliferation, failed to reduce osteoblast apoptosis, inhibited osteoblast maturation, and reduced the number of osteocyte processes, leading to massive osteocyte death. |
2017-12-15 |
2023-08-13 |
mouse |
| Zhi-Bin Tong, Helena Hogberg, David Kuo, Srilatha Sakamuru, Menghang Xia, Lena Smirnova, Thomas Hartung, David Gerhol. Characterization of three human cell line models for high-throughput neuronal cytotoxicity screening. Journal of applied toxicology : JAT. vol 37. issue 2. 2017-12-15. PMID:27143523. |
gene expression results suggest that differentiating luhmes cells may be susceptible to apoptosis because they express low levels of anti-apoptotic genes bcl2 and birc5/survivin, whereas sh-sy5y cells may be resistant to apoptosis because they express high levels of bcl2, birc5/survivin, and birc3 genes. |
2017-12-15 |
2023-08-13 |
human |
| H Kocic, I Arsic, M Stankovic, D Tiodorovic, V Ciric, G Koci. Proliferative, anti-apoptotic and immune-enhancing effects of L-arginine in culture of skin fibroblasts. Journal of biological regulators and homeostatic agents. vol 31. issue 3. 2017-12-14. PMID:28954469. |
our current study was aimed to explore the effect of l-arginine on skin fibroblast (l929) signaling pathways involved in cell proliferation (akt-pakt kinase, erk/perk1/2 kinase, jnk/pjnk kinase and pstat-1), apoptosis (bcl2 and bax) and immune defense (nf-κb and cd26). |
2017-12-14 |
2023-08-13 |
Not clear |
| Jiusheng Deng, Dongkyoo Park, Mengchang Wang, Ajay Nooka, Qiaoya Deng, Shannon Matulis, Jonathan Kaufman, Sagar Lonial, Lawrence H Boise, Jacques Galipeau, Xingming Den. BCL2-BH4 antagonist BDA-366 suppresses human myeloma growth. Oncotarget. vol 7. issue 19. 2017-12-11. PMID:27049723. |
in this study, we demonstrated that bda-366 induces robust apoptosis in mm cell lines and primary mm cells by inducing bcl2 conformational change. |
2017-12-11 |
2023-08-13 |
mouse |
| J Cui, W J Placze. PTBP1 modulation of MCL1 expression regulates cellular apoptosis induced by antitubulin chemotherapeutics. Cell death and differentiation. vol 23. issue 10. 2017-12-11. PMID:27367564. |
myeloid cell leukemia sequence 1 (mcl1), an anti-apoptotic bcl2 family protein, is a key regulator of intrinsic apoptosis. |
2017-12-11 |
2023-08-13 |
Not clear |
| Ji Liang, Ruixiu Cao, Xiongjun Wang, Yajuan Zhang, Pan Wang, Hong Gao, Chen Li, Fan Yang, Rong Zeng, Ping Wei, Dawei Li, Wenfeng Li, Weiwei Yan. Mitochondrial PKM2 regulates oxidative stress-induced apoptosis by stabilizing Bcl2. Cell research. vol 27. issue 3. 2017-12-11. PMID:28035139. |
mitochondrial pkm2 regulates oxidative stress-induced apoptosis by stabilizing bcl2. |
2017-12-11 |
2023-08-13 |
human |
| Ji Liang, Ruixiu Cao, Xiongjun Wang, Yajuan Zhang, Pan Wang, Hong Gao, Chen Li, Fan Yang, Rong Zeng, Ping Wei, Dawei Li, Wenfeng Li, Weiwei Yan. Mitochondrial PKM2 regulates oxidative stress-induced apoptosis by stabilizing Bcl2. Cell research. vol 27. issue 3. 2017-12-11. PMID:28035139. |
replacement of wild-type bcl2 with phosphorylation-deficient bcl2 t69a mutant sensitizes glioma cells to oxidative stress-induced apoptosis and impairs brain tumor formation in an orthotopic xenograft model. |
2017-12-11 |
2023-08-13 |
human |
| Ji Liang, Ruixiu Cao, Xiongjun Wang, Yajuan Zhang, Pan Wang, Hong Gao, Chen Li, Fan Yang, Rong Zeng, Ping Wei, Dawei Li, Wenfeng Li, Weiwei Yan. Mitochondrial PKM2 regulates oxidative stress-induced apoptosis by stabilizing Bcl2. Cell research. vol 27. issue 3. 2017-12-11. PMID:28035139. |
our findings uncover a novel mechanism through which mitochondrial pkm2 phosphorylates bcl2 and inhibits apoptosis directly, highlight the essential role of pkm2 in ros adaptation of cancer cells, and implicate hsp90-pkm2-bcl2 axis as a potential target for therapeutic intervention in glioblastoma. |
2017-12-11 |
2023-08-13 |
human |
| L M Zhao, A X Pan. Iodine-131 treatment of thyroid cancer cells leads to suppression of cell proliferation followed by induction of cell apoptosis and cell cycle arrest by regulation of B-cell translocation gene 2-mediated JNK/NF-κB pathways. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 50. issue 1. 2017-12-08. PMID:28099584. |
an increase in cell viability by up-regulation in bcl2 gene, a decrease in apoptosis by enhanced cdk2 gene expression and a decrease in cell cycle arrest at g0/g1 phase were also observed in sw579 cell lines transfected with silenced btg2 gene. |
2017-12-08 |
2023-08-13 |
human |
| Helen O Oladapo, Michael Tarpley, Scott J Sauer, Kezia A Addo, Shalonda M Ingram, Dillon Strepay, Ben K Ehe, Lhoucine Chdid, Michael Trinkler, Jose R Roques, David B Darr, Jodie M Fleming, Gayathri R Devi, Kevin P William. Pharmacological targeting of GLI1 inhibits proliferation, tumor emboli formation and in vivo tumor growth of inflammatory breast cancer cells. Cancer letters. vol 411. 2017-12-05. PMID:28965853. |
in addition, gant61 and jk184 significantly down-regulated gli1 targets that regulate cell cycle (cyclin d and e) and apoptosis (bcl2). |
2017-12-05 |
2023-08-13 |
Not clear |
| Cheng-Cao Sun, Shu-Jun Li, Feng Zhang, Jing-Yu Pan, Liang Wang, Cui-Li Yang, Yong-Yong Xi, De Jia L. Hsa-miR-329 exerts tumor suppressor function through down-regulation of MET in non-small cell lung cancer. Oncotarget. vol 7. issue 16. 2017-12-04. PMID:26909600. |
in addition, mir-329 promoted nsclc cell apoptosis, as indicated by up-regulation of key apoptosis gene cleaved caspase-3, and down-regulation of anti-apoptosis gene bcl2. |
2017-12-04 |
2023-08-13 |
Not clear |
| Hélène Lenden Hasse, Chloé Lescale, Joy J Bianchi, Wei Yu, Marie Bedora-Faure, Ludovic Derian. Generation and CRISPR/Cas9 editing of transformed progenitor B cells as a pseudo-physiological system to study DNA repair gene function in V(D)J recombination. Journal of immunological methods. vol 451. 2017-12-04. PMID:28882611. |
in this system, the bcl2 transgene alleviates imatinib-induced apoptosis enabling the analysis of induced v(d)j recombination. |
2017-12-04 |
2023-08-13 |
mouse |