| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lumin Wang, Hongfei Sun, Xiaofei Wang, Ni Hou, Lingyu Zhao, Dongdong Tong, Kang He, Yang Yang, Tusheng Song, Jun Yang, Chen Huan. EGR1 mediates miR-203a suppress the hepatocellular carcinoma cells progression by targeting HOXD3 through EGFR signaling pathway. Oncotarget. vol 7. issue 29. 2018-02-06. PMID:27244890. |
silencing hoxd3 could block transition of the g2/m phase, increase cell apoptosis, decrease the expression of cell cycle and apoptosis-related proteins, egfr, p-akt, p-erk, ccnb1, cdk1 and bcl2 by targeting egfr through egfr/akt and erk cell signaling pathways. |
2018-02-06 |
2023-08-13 |
Not clear |
| Hassan Nazari, Abolfazl Shirazi, Naser Shams-Esfandabadi, Azita Afzali, Ebrahim Ahmad. The effect of amniotic membrane stem cells as donor nucleus on gene expression in reconstructed bovine oocytes. The International journal of developmental biology. vol 60. issue 4-6. 2018-01-31. PMID:27389982. |
the expression pattern of genes involved in self-renewal and pluripotency (pou5f1, sox2, nanog), imprinting (igf2, igf2r), dna methylation (dnmt1, dnmt3a), histone deacetylation (hdac2), and apoptosis (bax, bcl2) were evaluated in nt and ivf derived embryos. |
2018-01-31 |
2023-08-13 |
cattle |
| Chengfu Yuan, Changdong Wang, Junjie Wang, Vikas Kumar, Firoz Anwar, Fangxiang Xiao, Gohar Mushtaq, Yufei Liu, Mohammad Amjad Kamal, Ding Yua. Inhibition on the growth of human MDA-MB-231 breast cancer cells in vitro and tumor growth in a mouse xenograft model by Se-containing polysaccharides from Pyracantha fortuneana. Nutrition research (New York, N.Y.). vol 36. issue 11. 2018-01-31. PMID:27865619. |
in vitro studies showed that treatment of triple negative breast cancer (tnbc) mda-mb-231 cells with se-pfps (1) inhibited cell growth dose-dependently by arresting cells at g2 phase via inhibiting cdc25c-cyclinb1/cdc2 pathway; (2) caused apoptosis associated with increased p53, bax, puma and noxa, decreased bcl2, increased bax/bcl2 ratio and increased activities of caspases 3/9, suggesting its effect on p53-mediated cytochrome c-caspase pathway. |
2018-01-31 |
2023-08-13 |
mouse |
| Xianyu Zhang, Ying Lu, Xin Cao, Tao Zhen, Damian Kovalovsk. Zbtb1 prevents default myeloid differentiation of lymphoid-primed multipotent progenitors. Oncotarget. vol 7. issue 37. 2018-01-29. PMID:27542215. |
finally, biased myeloid differentiation of zbtb1-deficient lmpp cells was not due to increased p53-dependent apoptosis as it was not reverted by transgenic bcl2 expression or p53 deficiency. |
2018-01-29 |
2023-08-13 |
mouse |
| YanFang Zheng, Yin Zhao, QingQing Luo, XiaoXia Liu, XiaoPing Liu, Ying Hu, Li Zo. Edaravone protects against cobalt chloride-induced dysfunctions in apoptosis and invasion in trophoblast cells. Molecular reproduction and development. vol 83. issue 7. 2018-01-24. PMID:27128210. |
metrics of apoptosis included measurement of cysteine-aspartic acid protease 3 (casp3) activity as well as bax and bcl2 expression. |
2018-01-24 |
2023-08-13 |
Not clear |
| YanFang Zheng, Yin Zhao, QingQing Luo, XiaoXia Liu, XiaoPing Liu, Ying Hu, Li Zo. Edaravone protects against cobalt chloride-induced dysfunctions in apoptosis and invasion in trophoblast cells. Molecular reproduction and development. vol 83. issue 7. 2018-01-24. PMID:27128210. |
cocl2 inhibited the proliferation of h8 cells, promoted apoptosis, and up-regulated casp3 activation and bax expression while inhibiting bcl2 expression. |
2018-01-24 |
2023-08-13 |
Not clear |
| YanFang Zheng, Yin Zhao, QingQing Luo, XiaoXia Liu, XiaoPing Liu, Ying Hu, Li Zo. Edaravone protects against cobalt chloride-induced dysfunctions in apoptosis and invasion in trophoblast cells. Molecular reproduction and development. vol 83. issue 7. 2018-01-24. PMID:27128210. |
edaravone significantly increased h8 cell proliferation; inhibited apoptosis by down-regulating casp3 activation and bax production while promoting bcl2 stability; and ameliorated the migration and invasion phenotypes associated with cocl2 treatment. |
2018-01-24 |
2023-08-13 |
Not clear |
| Sharad Verma, Sukriti Goyal, Chetna Tyagi, Salma Jamal, Aditi Singh, Abhinav Grove. BIM (BCL-2 interacting mediator of cell death) SAHB (stabilized α helix of BCL2) not always convinces BAX (BCL-2-associated X protein) for apoptosis. Journal of molecular graphics & modelling. vol 67. 2018-01-19. PMID:27262527. |
bim (bcl-2 interacting mediator of cell death) sahb (stabilized α helix of bcl2) not always convinces bax (bcl-2-associated x protein) for apoptosis. |
2018-01-19 |
2023-08-13 |
Not clear |
| Sharad Verma, Sukriti Goyal, Chetna Tyagi, Salma Jamal, Aditi Singh, Abhinav Grove. BIM (BCL-2 interacting mediator of cell death) SAHB (stabilized α helix of BCL2) not always convinces BAX (BCL-2-associated X protein) for apoptosis. Journal of molecular graphics & modelling. vol 67. 2018-01-19. PMID:27262527. |
the interaction of bax (bcl-2-associated x protein) with bim (bcl-2 interacting mediator of cell death) sahb (stabilized α helix of bcl2) directly initiates bax-mediated mitochondrial apoptosis. |
2018-01-19 |
2023-08-13 |
Not clear |
| A A Guirguis, C I Slape, L M Failla, J Saw, C S Tremblay, D R Powell, F Rossello, A Wei, A Strasser, D J Curti. PUMA promotes apoptosis of hematopoietic progenitors driving leukemic progression in a mouse model of myelodysplasia. Cell death and differentiation. vol 23. issue 6. 2018-01-16. PMID:26742432. |
using the nup98-hoxd13 (nhd13) transgenic mouse model of mds, we previously reported that overexpression of the anti-apoptotic protein bcl2, blocked apoptosis and improved cytopenias, paradoxically, delaying leukemic progression. |
2018-01-16 |
2023-08-13 |
mouse |
| Tiening Zhang, Xun Cai, Qi Li, Peng Xue, Zhixiao Chen, Xiao Dong, Ying Xu. Hsa-miR-875-5p exerts tumor suppressor function through down-regulation of EGFR in colorectal carcinoma (CRC). Oncotarget. vol 7. issue 27. 2018-01-15. PMID:27302926. |
in addition, mir-875-5p induced apoptosis, as indicated by concomitantly with up-regulation of key apoptosis protein cleaved caspase-3, and down-regulation of anti-apoptosis protein bcl2. |
2018-01-15 |
2023-08-13 |
Not clear |
| Janina Dose, Almut Nebel, Stefanie Piegholdt, Gerald Rimbach, Patricia Huebb. Influence of the APOE genotype on hepatic stress response: Studies in APOE targeted replacement mice and human liver cells. Free radical biology & medicine. vol 96. 2018-01-09. PMID:27130033. |
therefore, we studied biomarkers of oxidative status (glutathione levels, 3-nitrotyrosine adducts, protein carbonyl concentration), er stress (xbp1(s), bip, ddit3), proteasome activity, mitochondrial function (respiratory complexes, atp levels and mitochondrial membrane potential as well as biomarkers of mitochondrial biogenesis, fission and fusion), autophagy (lc3, lamp2a), apoptosis (bcl2, bax, cycs) and dna damage in the liver of apoe targeted replacement (tr) mice and in huh7 hepatocytes overexpressing the apoe3 and the apoe4 isoform, respectively. |
2018-01-09 |
2023-08-13 |
mouse |
| Yunyan Pan, Yanling Zhang, Lijun Chen, Yan Liu, Yanlin Feng, Junyuan Ya. The Critical Role of Rab31 in Cell Proliferation and Apoptosis in Cancer Progression. Molecular neurobiology. vol 53. issue 7. 2018-01-08. PMID:26245486. |
meanwhile, rab31 inhibits u87 and siha cell apoptosis, and decreased the bax and pig3 expression, but enhanced bcl2 expression. |
2018-01-08 |
2023-08-13 |
Not clear |
| Chang-Ae Shin, Hyun-Woo Cho, A-Ri Shin, Hyun-Jung Sohn, Hyun-Il Cho, Tai-Gyu Ki. Co-expression of CD40L with CD70 or OX40L increases B-cell viability and antitumor efficacy. Oncotarget. vol 7. issue 29. 2018-01-08. PMID:27323820. |
notably, expression of cd40l augmented b-cell viability by inhibiting apoptosis through upregulated expression of the anti-apoptotic molecules bcl2, bcl-xl and bax. |
2018-01-08 |
2023-08-13 |
Not clear |
| Devora Champa, Arturo Orlacchio, Bindi Patel, Michela Ranieri, Anton A Shemetov, Vladislav V Verkhusha, Ana Maria Cuervo, Antonio Di Cristofan. Obatoclax kills anaplastic thyroid cancer cells by inducing lysosome neutralization and necrosis. Oncotarget. vol 7. issue 23. 2018-01-05. PMID:27144341. |
these tumors are intrinsically resistant to cell death, even when their driver oncogenic signaling pathways are inhibited.we have undertaken a detailed analysis, in mouse and human thyroid cancer cells, of the mechanism through which obatoclax, a pan-inhibitor of the anti-apoptotic proteins of the bcl2 family, effectively reduces tumor growth in vitro and in vivo.we demonstrate that obatoclax does not induce apoptosis, but rather necrosis of thyroid cancer cells, and that non-transformed thyroid cells are significantly less affected by this compound. |
2018-01-05 |
2023-08-13 |
mouse |
| Masoumeh Falah, Mohammad Najafi, Massoud Houshmand, Mohammad Farhad. Expression levels of the BAK1 and BCL2 genes highlight the role of apoptosis in age-related hearing impairment. Clinical interventions in aging. vol 11. 2018-01-05. PMID:27555755. |
expression levels of the bak1 and bcl2 genes highlight the role of apoptosis in age-related hearing impairment. |
2018-01-05 |
2023-08-13 |
human |
| Masoumeh Falah, Mohammad Najafi, Massoud Houshmand, Mohammad Farhad. Expression levels of the BAK1 and BCL2 genes highlight the role of apoptosis in age-related hearing impairment. Clinical interventions in aging. vol 11. 2018-01-05. PMID:27555755. |
in this study, we compared the expression of the genes bak1 and bcl2 as two arms of the intrinsic apoptosis pathway between patients with arhi and healthy subjects. |
2018-01-05 |
2023-08-13 |
human |
| Yuan Zhang, Kai Shen, Ying Bai, Xuan Lv, Rongrong Huang, Wei Zhang, Jie Chao, Lan K Nguyen, Jun Hua, Guangming Gan, Gang Hu, Honghong Ya. Mir143-BBC3 cascade reduces microglial survival via interplay between apoptosis and autophagy: Implications for methamphetamine-mediated neurotoxicity. Autophagy. vol 12. issue 9. 2017-12-29. PMID:27464000. |
bbc3 (bcl2 binding component 3) is a known apoptosis inducer; however, its role in microglial survival remains poorly understood. |
2017-12-29 |
2023-08-13 |
mouse |
| Cheng-Cao Sun, Shu-Jun Li, De-Jia L. Hsa-miR-134 suppresses non-small cell lung cancer (NSCLC) development through down-regulation of CCND1. Oncotarget. vol 7. issue 24. 2017-12-27. PMID:27166267. |
in addition, mir-134 induced apoptosis, as indicated by concomitantly with up-regulation of key apoptosis protein cleaved caspase-3, and down-regulation of anti-apoptosis protein bcl2. |
2017-12-27 |
2023-08-13 |
Not clear |
| Cheng-Yen Tsai, Su-Ying Wen, Shi-Yann Cheng, Chung-Hsing Wang, Yao-Chih Yang, Vijaya Padma Viswanadha, Chih-Yang Huang, Wei-Wen Ku. Nrf2 Activation as a Protective Feedback to Limit Cell Death in High Glucose-Exposed Cardiomyocytes. Journal of cellular biochemistry. vol 118. issue 7. 2017-12-27. PMID:27859591. |
knockdown of nrf2 by sirna transfection increased cleaved-caspase3, reduced bcl2 in the cellular protein level and further exacerbated hg-induced apoptosis. |
2017-12-27 |
2023-08-13 |
rat |