| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dan-Dan Li, Zhi Luo, Guang-Hui Chen, Yu-Feng Song, Chuan-Chuan Wei, Ya-Xiong Pa. Identification of apoptosis-related genes Bcl2 and Bax from yellow catfish Pelteobagrus fulvidraco and their transcriptional responses to waterborne and dietborne zinc exposure. Gene. vol 633. 2017-09-29. PMID:28864113. |
to this end, we cloned full-length cdna sequences of bcl2 and three bax subtypes involved in apoptosis in p. fulvidraco, explored their mrna expressions in responses to different zn exposure pathways. |
2017-09-29 |
2023-08-13 |
Not clear |
| Dan-Dan Li, Zhi Luo, Guang-Hui Chen, Yu-Feng Song, Chuan-Chuan Wei, Ya-Xiong Pa. Identification of apoptosis-related genes Bcl2 and Bax from yellow catfish Pelteobagrus fulvidraco and their transcriptional responses to waterborne and dietborne zinc exposure. Gene. vol 633. 2017-09-29. PMID:28864113. |
for the first time, we characterized the full-length cdna sequences of bcl2 and three bax subtypes, determined their expression profiles and transcriptional responses to different zn exposure pathways, which would contribute to our understanding of the molecular basis of apoptosis, and also provide new insights into physiological responses to different zn exposure pathways. |
2017-09-29 |
2023-08-13 |
Not clear |
| V M Patel, K Balakrishnan, M Douglas, T Tibbitts, E Y Xu, J L Kutok, M Ayers, A Sarkar, R Guerrieri, W G Wierda, S O'Brien, N Jain, H M Stern, V Gandh. Duvelisib treatment is associated with altered expression of apoptotic regulators that helps in sensitization of chronic lymphocytic leukemia cells to venetoclax (ABT-199). Leukemia. vol 31. issue 9. 2017-09-28. PMID:28017967. |
the bcl2 inhibitor venetoclax induced greater apoptosis in ex vivo-cultured cll cells obtained from patients on duvelisib compared with pre-treatment cll cells from the same patients. |
2017-09-28 |
2023-08-13 |
Not clear |
| Yelisetti Uma Mahesh, Henderson Rose Winnie Gibence, Sisinthy Shivaji, Brahmasani Sambasiva Ra. Effect of different cryo-devices on in vitro maturation and development of vitrified-warmed immature buffalo oocytes. Cryobiology. vol 75. 2017-09-27. PMID:28093199. |
the expression of oocyte secreting factors and their receptors (gdf9, bmp15, bmpr2, tgfbr1) and apoptosis related genes (bcl2, bax, p53, c-myc) were compared in vitrified-warmed oocytes after in vitro maturation. |
2017-09-27 |
2023-08-13 |
Not clear |
| Florian Ebner, Vitaly Sedlyarov, Saren Tasciyan, Masa Ivin, Franz Kratochvill, Nina Gratz, Lukas Kenner, Andreas Villunger, Michael Sixt, Pavel Kovari. The RNA-binding protein tristetraprolin schedules apoptosis of pathogen-engaged neutrophils during bacterial infection. The Journal of clinical investigation. vol 127. issue 6. 2017-09-26. PMID:28504646. |
neutrophil transcriptome analysis revealed that decreased apoptosis of ttp-deficient neutrophils was specifically associated with elevated expression of myeloid cell leukemia 1 (mcl1) but not other antiapoptotic b cell leukemia/lymphoma 2 (bcl2) family members. |
2017-09-26 |
2023-08-13 |
mouse |
| Sudeshna Mukherjee, Sayan Ghosh, Dipesh Kr Das, Priyanka Chakraborty, Sreetama Choudhury, Payal Gupta, Arghya Adhikary, Sanjit Dey, Sreya Chattopadhya. Gold-conjugated green tea nanoparticles for enhanced anti-tumor activities and hepatoprotection--synthesis, characterization and in vitro evaluation. The Journal of nutritional biochemistry. vol 26. issue 11. 2017-09-25. PMID:26310506. |
these nps significantly decreased nuclear translocation of nf-κb, coupled with decreased phosphorylation of iĸb and down-regulation of nf-κb-dependent anti-apoptotic proteins bcl2 and akt in a dose-dependent manner, triggering onset of apoptosis. |
2017-09-25 |
2023-08-13 |
mouse |
| Qiong Wang, Yingjun She, Xiaobao Bi, Baisong Zhao, Xiangcai Ruan, Yonghong Ta. Dexmedetomidine Protects PC12 Cells from Lidocaine-Induced Cytotoxicity Through Downregulation of COL3A1 Mediated by miR-let-7b. DNA and cell biology. vol 36. issue 7. 2017-09-20. PMID:28436683. |
meanwhile, proteins involved in cell apoptosis, such as bcl2 and caspase 3, were impacted as well. |
2017-09-20 |
2023-08-13 |
Not clear |
| Meike Vogler, Harriet S Walter, Martin J S Dye. Targeting anti-apoptotic BCL2 family proteins in haematological malignancies - from pathogenesis to treatment. British journal of haematology. vol 178. issue 3. 2017-09-19. PMID:28449207. |
the b-cell lymphoma 2 (bcl2) family of proteins comprise key regulators of apoptosis and are implicated in the pathogenesis of many malignancies, including lymphomas and leukaemias. |
2017-09-19 |
2023-08-13 |
Not clear |
| Eugene Roscioli, Hai B Tran, Hubertus Jersmann, Phan T Nguyen, Emily Hopkins, Susan Lester, Nigel Farrow, Peter Zalewski, Paul N Reynolds, Sandra Hodg. The uncoupling of autophagy and zinc homeostasis in airway epithelial cells as a fundamental contributor to COPD. American journal of physiology. Lung cellular and molecular physiology. vol 313. issue 3. 2017-09-18. PMID:28596293. |
we applied a human ex vivo air-liquid interface model, a murine model of smoke exposure, and human lung tissues and investigated zn, zip1, and zip2 zn-influx proteins, autophagy [microtubule-associated 1a/1b-light chain-3 (lc3), beclin-1], autophagic flux (sequestosome), apoptosis [bcl2; x-linked inhibitor of apoptosis (xiap), poly (adp)-ribose polymerase (parp)], and inflammation [thymic stromal lymphopoietin (tslp), regulated on activation, normal t cell expressed and secreted (rantes), and il-1β]. |
2017-09-18 |
2023-08-13 |
mouse |
| Eugene Roscioli, Hai B Tran, Hubertus Jersmann, Phan T Nguyen, Emily Hopkins, Susan Lester, Nigel Farrow, Peter Zalewski, Paul N Reynolds, Sandra Hodg. The uncoupling of autophagy and zinc homeostasis in airway epithelial cells as a fundamental contributor to COPD. American journal of physiology. Lung cellular and molecular physiology. vol 313. issue 3. 2017-09-18. PMID:28596293. |
autophagic dysfunction due to cs exposure coupled with zn depletion also induced apoptosis, with the reduction of antiapoptotic and antiautophagic proteins bcl2 and xiap and parp cleavage. |
2017-09-18 |
2023-08-13 |
mouse |
| Ping Yang, Fulu Dong, Quansheng Zho. Triptonide acts as a novel potent anti-lymphoma agent with low toxicity mainly through inhibition of proto-oncogene Lyn transcription and suppression of Lyn signal pathway. Toxicology letters. vol 278. 2017-08-21. PMID:28666825. |
cell biological studies showed that triptonide at the doses of 2.5-10nm notably suppressed b-lymphoma cell colony-forming capability, and that triptonide at the dose of 20nm promoted apoptosis through activation of parp and caspase 3, but reduction of bcl2 protein levels in the lymphoma cells. |
2017-08-21 |
2023-08-13 |
mouse |
| Michał Szewczuk, Karolina Boguszewska, Marta Żebrowska, Ewa Balcerczak, Marta Stasiak, Maria Świątkowska, Katarzyna Błaszczak-Świątkiewic. Virus-directed enzyme prodrug therapy and the assessment of the cytotoxic impact of some benzimidazole derivatives. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 39. issue 7. 2017-08-15. PMID:28752801. |
the apoptosis was confirmed by generation of bax gene and protein and reduction of bcl2 gene and protein. |
2017-08-15 |
2023-08-13 |
Not clear |
| Charlotte Viant, Sophie Guia, Robert J Hennessy, Jai Rautela, Kim Pham, Claire Bernat, Wilford Goh, Yuhao Jiao, Rebecca Delconte, Michael Roger, Vanina Simon, Fernando Souza-Fonseca-Guimaraes, Stephanie Grabow, Gabrielle T Belz, Benjamin T Kile, Andreas Strasser, Daniel Gray, Phillip D Hodgkin, Bruce Beutler, Eric Vivier, Sophie Ugolini, Nicholas D Huntingto. Cell cycle progression dictates the requirement for BCL2 in natural killer cell survival. The Journal of experimental medicine. vol 214. issue 2. 2017-08-14. PMID:28057804. |
in these mice, nk cells in cycle were protected against apoptosis, and nk cell counts were restored in inflammatory conditions, suggesting a redundant role for bcl2 in proliferating nk cells. |
2017-08-14 |
2023-08-13 |
mouse |
| Xinzheng Jia, Hongjia Ouyang, Bahareldin Ali Abdalla, Haiping Xu, Qinghua Nie, Xiquan Zhan. miR-16 controls myoblast proliferation and apoptosis through directly suppressing Bcl2 and FOXO1 activities. Biochimica et biophysica acta. Gene regulatory mechanisms. vol 1860. issue 6. 2017-08-14. PMID:28258011. |
mir-16 controls myoblast proliferation and apoptosis through directly suppressing bcl2 and foxo1 activities. |
2017-08-14 |
2023-08-13 |
chicken |
| Xinzheng Jia, Hongjia Ouyang, Bahareldin Ali Abdalla, Haiping Xu, Qinghua Nie, Xiquan Zhan. miR-16 controls myoblast proliferation and apoptosis through directly suppressing Bcl2 and FOXO1 activities. Biochimica et biophysica acta. Gene regulatory mechanisms. vol 1860. issue 6. 2017-08-14. PMID:28258011. |
here, we reported that mir-16 inhibited myoblast proliferation and promoted myoblast apoptosis by directly targeting bcl2 and foxo1. |
2017-08-14 |
2023-08-13 |
chicken |
| Xinzheng Jia, Hongjia Ouyang, Bahareldin Ali Abdalla, Haiping Xu, Qinghua Nie, Xiquan Zhan. miR-16 controls myoblast proliferation and apoptosis through directly suppressing Bcl2 and FOXO1 activities. Biochimica et biophysica acta. Gene regulatory mechanisms. vol 1860. issue 6. 2017-08-14. PMID:28258011. |
consist to the effect of mir-16 on myogenesis, specific inhibition of bcl2 or foxo1 significantly suppressed myoblast proliferation and induced myoblast apoptosis, indicating that both bcl2 and foxo1 contributed to mir-16 regulatory function in myogenesis. |
2017-08-14 |
2023-08-13 |
chicken |
| Annalisa Conti, Maria Teresa Majorini, Enrico Fontanella, Alberto Bardelli, Mauro Giacca, Domenico Delia, Miguel Mano, Daniele Leci. Lemur tyrosine kinase 2 (LMTK2) is a determinant of cell sensitivity to apoptosis by regulating the levels of the BCL2 family members. Cancer letters. vol 389. 2017-08-08. PMID:28040547. |
lemur tyrosine kinase 2 (lmtk2) is a determinant of cell sensitivity to apoptosis by regulating the levels of the bcl2 family members. |
2017-08-08 |
2023-08-13 |
Not clear |
| Marta Czernik, Paola Toschi, Federica Zacchini, Domenico Iuso, Grażyna Ewa Pta. Deregulated Expression of Mitochondrial Proteins Mfn2 and Bcnl3L in Placentae from Sheep Somatic Cell Nuclear Transfer (SCNT) Conceptuses. PloS one. vol 12. issue 1. 2017-08-03. PMID:28076382. |
likely, this accumulation of damaged organelles led to uncontrolled apoptosis in scnt placentae, as demonstrated by the high number of apoptotic bodies, fragmented cytoplasm, condensed chromatin, lack of integrity of the nuclear membrane and the perturbed mrna expression of apoptotic genes (bcl2 and bax). |
2017-08-03 |
2023-08-13 |
Not clear |
| Mary Ann Anderson, Jing Deng, John F Seymour, Constantine Tam, Su Young Kim, Joshua Fein, Lijian Yu, Jennifer R Brown, David Westerman, Eric G Si, Ian J Majewski, David Segal, Sari L Heitner Enschede, David C S Huang, Matthew S Davids, Anthony Letai, Andrew W Robert. The BCL2 selective inhibitor venetoclax induces rapid onset apoptosis of CLL cells in patients via a TP53-independent mechanism. Blood. vol 127. issue 25. 2017-08-02. PMID:27069256. |
the bcl2 selective inhibitor venetoclax induces rapid onset apoptosis of cll cells in patients via a tp53-independent mechanism. |
2017-08-02 |
2023-08-13 |
Not clear |
| Mary Ann Anderson, Jing Deng, John F Seymour, Constantine Tam, Su Young Kim, Joshua Fein, Lijian Yu, Jennifer R Brown, David Westerman, Eric G Si, Ian J Majewski, David Segal, Sari L Heitner Enschede, David C S Huang, Matthew S Davids, Anthony Letai, Andrew W Robert. The BCL2 selective inhibitor venetoclax induces rapid onset apoptosis of CLL cells in patients via a TP53-independent mechanism. Blood. vol 127. issue 25. 2017-08-02. PMID:27069256. |
bcl2 blunts activation of the mitochondrial pathway to apoptosis, and high-level expression is required for chronic lymphocytic leukemia (cll) survival. |
2017-08-02 |
2023-08-13 |
Not clear |