| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Zhu, M Y Zhao, X H Li, Q Fu, Z F Zhou, C F Huang, X S Zhang, H L Huang, Y Tan, J X Li, J N Li, S Huang, M Ashraf, C Lu, J M Chen, J Zhuang, H M Gu. Effect of low temperatures on BAX and BCL2 proteins in rats with spinal cord ischemia reperfusion injury. Genetics and molecular research : GMR. vol 14. issue 3. 2016-07-06. PMID:26400280. |
group c exhibited greater neuronal apoptosis, higher bax expression, but lower bcl2 expression than the other groups. |
2016-07-06 |
2023-08-13 |
rat |
| P Zhu, M Y Zhao, X H Li, Q Fu, Z F Zhou, C F Huang, X S Zhang, H L Huang, Y Tan, J X Li, J N Li, S Huang, M Ashraf, C Lu, J M Chen, J Zhuang, H M Gu. Effect of low temperatures on BAX and BCL2 proteins in rats with spinal cord ischemia reperfusion injury. Genetics and molecular research : GMR. vol 14. issue 3. 2016-07-06. PMID:26400280. |
compared with group a, bax was expressed less and bcl2 more in group b, and there was less apoptosis in group b. hypothermia preserves hind limb motor function and reduces neuronal death, thereby protecting rats from scii. |
2016-07-06 |
2023-08-13 |
rat |
| Thomas G Hopkins, Manuela Mura, Hiba A Al-Ashtal, Roni M Lahr, Normala Abd-Latip, Katrina Sweeney, Haonan Lu, Justin Weir, Mona El-Bahrawy, Jennifer H Steel, Sadaf Ghaem-Maghami, Eric O Aboagye, Andrea J Berman, Sarah P Blagde. The RNA-binding protein LARP1 is a post-transcriptional regulator of survival and tumorigenesis in ovarian cancer. Nucleic acids research. vol 44. issue 3. 2016-07-06. PMID:26717985. |
we demonstrate that, through an interaction with the 3' untranslated regions (3' utrs) of bcl2 and bik, larp1 stabilizes bcl2 but destabilizes bik with the net effect of resisting apoptosis. |
2016-07-06 |
2023-08-13 |
Not clear |
| Jinhua Jiang, Shenggan Wu, Xinju Liu, Yanhua Wang, Xuehua An, Leiming Cai, Xueping Zha. Effect of acetochlor on transcription of genes associated with oxidative stress, apoptosis, immunotoxicity and endocrine disruption in the early life stage of zebrafish. Environmental toxicology and pharmacology. vol 40. issue 2. 2016-06-29. PMID:26318563. |
results demonstrated that the transcription patterns of many key genes involved in the hypothalamic-pituitary-gonadal/thyroid (hpg/hpt) axis (e.g., vtg1, erβ1, cyp19a and trα), cell apoptosis pathway (e.g., bcl2, bax, p53 and cas8), as well as innate immunity (e.g., cxcl-c1c, il-1β and tnfα) were affected in newly hatched zebrafish after exposure to acetochlor. |
2016-06-29 |
2023-08-13 |
cat |
| Yangling Mu, Chunmei Zhao, Nicolas Toni, Jun Yao, Fred H Gag. Distinct roles of NMDA receptors at different stages of granule cell development in the adult brain. eLife. vol 4. 2016-06-28. PMID:26473971. |
here we demonstrate that nascent gcs lacking nmdars but rescued from apoptosis by overexpressing the pro-survival protein bcl2 were deficient in spine formation. |
2016-06-28 |
2023-08-13 |
Not clear |
| Olga Amelkina, Lina Zschockelt, Johanna Painer, Rodrigo Serra, Francisco Villaespesa, Beate C Braun, Katarina Jewgeno. Apoptosis-Related Factors in the Luteal Phase of the Domestic Cat and Their Involvement in the Persistence of Corpora Lutea in Lynx. PloS one. vol 10. issue 11. 2016-06-27. PMID:26599641. |
our factors of interest included agents of the intrinsic apoptosis pathway, i.e., pro-survival b-cell cll/lymphoma 2 (bcl2) and pro-apoptotic bcl2-associated x protein (bax), the executioner caspase-3 (casp3), as well as of the extrinsic pathway, i.e., pro-apoptotic receptor fas, and tumor necrosis factor (tnf) and its receptors (pro-apoptotic tnfrsf1a and pro-survival tnfrsf1b). |
2016-06-27 |
2023-08-13 |
cat |
| Jéssica Arribas, Esteban Giménez, Ricard Marcos, Antonia Velázque. Novel antiapoptotic effect of TBX15: overexpression of TBX15 reduces apoptosis in cancer cells. Apoptosis : an international journal on programmed cell death. vol 20. issue 10. 2016-06-21. PMID:26216026. |
consistently, apoptosis was reduced in tbx15 transfected cells (p < 0.01) which also showed a decrease of the proapoptotic bax regulator and an increase of the antiapoptotic bcl2 and bcl-xl regulators. |
2016-06-21 |
2023-08-13 |
Not clear |
| Ana Teresa G Fernandes, Natália P Rocha, Elena Vendrame, Fabio Russomano, Beatriz J Grinsztejn, Ruth K Friedman, Amanda C Pinto, Evandro M Klumb, Elyzabeth Avvad, Jacyara Macedo, Otoniel Martínez-Maza, Maria da Gloria Bonecini-Almeid. Polymorphism in apoptotic BAX (-248G>A) gene but not in anti-apoptotic BCL2 (-938C>A) gene and its protein and mRNA expression are associated with cervical intraepithelial neoplasia. Apoptosis : an international journal on programmed cell death. vol 20. issue 10. 2016-06-21. PMID:26272263. |
apoptosis is regulated by different pathways involving genes that either promote (bcl2 gene) or inhibit (bax gene) cell death. |
2016-06-21 |
2023-08-13 |
human |
| Seyedeh Habibeh Mirmajidi, Ramin Ataee, Ali Barzegar, Novin Nikbakhsh, Mohammad Shaterpou. Low Expression of the bcl2 Gene in Gastric Adenocarcinomas in Mazandaran Province of Iran. Asian Pacific journal of cancer prevention : APJCP. vol 16. issue 14. 2016-06-21. PMID:26320497. |
the bcl2 family has a key role in the regulation of apoptosis and change in its expression can contribute to cancer. |
2016-06-21 |
2023-08-13 |
Not clear |
| Gürkan Bal, Matthias E Futschik, Daniela Hartl, Frauke Ringel, Julian Kamhieh-Milz, Viktor Sterzer, Jörg D Hoheisel, Mohamed S S Alhamdani, Abdulgabar Salam. Identification of novel biomarkers in chronic immune thrombocytopenia (ITP) by microarray-based serum protein profiling. British journal of haematology. vol 172. issue 4. 2016-06-21. PMID:26628061. |
in addition to oncoproteins and tumour-suppressor proteins, including apoptosis regulator bcl2, breast cancer type 1 susceptibility protein (brca1), fanconi anaemia complementation group c (fancc) and vascular endothelial growth factor a (vegfa), we detected six anti-nuclear autoantibodies in a subset of itp patients: anti-pcna, anti-smd, anti-ro/ssa60, anti-ro/ssa52, anti-la/ssb and anti-rnpc antibodies. |
2016-06-21 |
2023-08-13 |
Not clear |
| Daniel J Murphy, Nathiya Muthalag. BIM's up first. Molecular & cellular oncology. vol 2. issue 2. 2016-06-16. PMID:27308426. |
in vivo analysis of the genetic determinants of myc-induced apoptosis reveals a specific requirement for the bcl2 family protein bim (bcl2l11). |
2016-06-16 |
2023-08-13 |
Not clear |
| Biswajit Chakraborty, Debasmita Dutta, Sanjukta Mukherjee, Supriya Das, Nakul C Maiti, Padma Das, Chinmay Chowdhur. Synthesis and biological evaluation of a novel betulinic acid derivative as an inducer of apoptosis in human colon carcinoma cells (HT-29). European journal of medicinal chemistry. vol 102. 2016-06-08. PMID:26248310. |
elevated level of ros generation, activation of caspase 3 and caspase 9, dna fragmentation, higher expression of bax and bad, lower expression of bcl2 and bcl-xl, and increased level of bax/bcl-xl ratio identified 2c as a promising inducer of apoptosis that follows a mitochondria dependent pathway. |
2016-06-08 |
2023-08-13 |
human |
| M Mousai, S M Hosseini, M Hajian, F Jafarpour, V Asgari, M Forouzanfar, M H Nasr-Esfahan. Effect of epigenetic modification with trichostatin A and S-adenosylhomocysteine on developmental competence and POU5F1-EGFP expression of interspecies cloned embryos in dog. Zygote (Cambridge, England). vol 23. issue 5. 2016-06-07. PMID:25314965. |
the expression levels of bcl2 and p53 were significantly affected in tsa-treated cells compared with untreated cells, whereas sah treatment had no significant effect on cell apoptosis. |
2016-06-07 |
2023-08-13 |
dog |
| Jinhua Jiang, Shenggan Wu, Yanhua Wang, Xuehua An, Leiming Cai, Xueping Zhao, Changxing W. Carbendazim has the potential to induce oxidative stress, apoptosis, immunotoxicity and endocrine disruption during zebrafish larvae development. Toxicology in vitro : an international journal published in association with BIBRA. vol 29. issue 7. 2016-06-07. PMID:26055223. |
the up-regulation of p53, apaf1, cas8 and the down-regulation of bcl2, mdm2, cas3 in the apoptosis pathway, as well as the increased expression of cytokines and chemokines, including cxcl-c1c, ccl1, il-1b, ifn, il-8, and tnfα, suggested carbendazim might trigger apoptosis and immune response during zebrafish larval development. |
2016-06-07 |
2023-08-13 |
mouse |
| Michaela Angelika Ihle, Marcel Trautmann, Helen Kuenstlinger, Sebastian Huss, Carina Heydt, Jana Fassunke, Eva Wardelmann, Sebastian Bauer, Hans-Ulrich Schildhaus, Reinhard Buettner, Sabine Merkelbach-Brus. miRNA-221 and miRNA-222 induce apoptosis via the KIT/AKT signalling pathway in gastrointestinal stromal tumours. Molecular oncology. vol 9. issue 7. 2016-06-03. PMID:25898773. |
our results demonstrate that mir-221 and mir-222 which are downregulated in wildtype and mutated gists, induce apoptosis in vitro by a signalling cascade involving kit, akt and bcl2. |
2016-06-03 |
2023-08-13 |
Not clear |
| M F Riley, M J You, A S Multani, G Lozan. Mdm2 overexpression and p73 loss exacerbate genomic instability and dampen apoptosis, resulting in B-cell lymphoma. Oncogene. vol 35. issue 3. 2016-06-03. PMID:25915849. |
b-cell lymphomas from mdm2(tg);p73(+/-) mice retain the remaining p73 allele, exhibit elevated levels of the antiapoptotic protein bcl2 and thus dampen apoptosis. |
2016-06-03 |
2023-08-13 |
mouse |
| Rekha Pal, Stephanie Green. microRNA-10b Is Overexpressed and Critical for Cell Survival and Proliferation in Medulloblastoma. PloS one. vol 10. issue 9. 2016-06-03. PMID:26394044. |
abt-737 and abt-199, potent inhibitors of bcl2, downregulated the expression of mirna-10b and increased apoptosis. |
2016-06-03 |
2023-08-13 |
Not clear |
| Yin Yang, Zongdan Wang, Luan Sun, Lipei Shao, Nan Yang, Dawei Yu, Xin Zhang, Xiao Han, Yujie Su. SATB1 Mediates Long-Range Chromatin Interactions: A Dual Regulator of Anti-Apoptotic BCL2 and Pro-Apoptotic NOXA Genes. PloS one. vol 10. issue 9. 2016-06-03. PMID:26422397. |
we previously demonstrated that satb1 mediated specific long-range chromosomal interactions between the mbr enhancer located within 3'-utr of the bcl2 gene and the promoter to regulate bcl2 expression during early apoptosis. |
2016-06-03 |
2023-08-13 |
Not clear |
| Yin Yang, Zongdan Wang, Luan Sun, Lipei Shao, Nan Yang, Dawei Yu, Xin Zhang, Xiao Han, Yujie Su. SATB1 Mediates Long-Range Chromatin Interactions: A Dual Regulator of Anti-Apoptotic BCL2 and Pro-Apoptotic NOXA Genes. PloS one. vol 10. issue 9. 2016-06-03. PMID:26422397. |
the satb1-mediated dynamic switch of the chromatin loop structures was essential for the cooperative expression of the bcl2 and noxa genes in apoptosis. |
2016-06-03 |
2023-08-13 |
Not clear |
| C Woess, S Tuzlak, V Labi, M Drach, D Bertele, P Schneider, A Villunge. Combined loss of the BH3-only proteins Bim and Bmf restores B-cell development and function in TACI-Ig transgenic mice. Cell death and differentiation. vol 22. issue 9. 2016-06-02. PMID:25698446. |
here, we show that two pro-apoptotic members of the 'bcl2 homology domain 3-only' subgroup of the bcl2 family, bcl2 interacting mediator of cell death (bim) and bcl2 modifying factor (bmf), mediate apoptosis in the context of taci-ig overexpression that effectively neutralizes baff as well as april. |
2016-06-02 |
2023-08-13 |
mouse |