| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gürkan Bal, Matthias E Futschik, Daniela Hartl, Frauke Ringel, Julian Kamhieh-Milz, Viktor Sterzer, Jörg D Hoheisel, Mohamed S S Alhamdani, Abdulgabar Salam. Identification of novel biomarkers in chronic immune thrombocytopenia (ITP) by microarray-based serum protein profiling. British journal of haematology. vol 172. issue 4. 2016-06-21. PMID:26628061. |
in addition to oncoproteins and tumour-suppressor proteins, including apoptosis regulator bcl2, breast cancer type 1 susceptibility protein (brca1), fanconi anaemia complementation group c (fancc) and vascular endothelial growth factor a (vegfa), we detected six anti-nuclear autoantibodies in a subset of itp patients: anti-pcna, anti-smd, anti-ro/ssa60, anti-ro/ssa52, anti-la/ssb and anti-rnpc antibodies. |
2016-06-21 |
2023-08-13 |
Not clear |
| Daniel J Murphy, Nathiya Muthalag. BIM's up first. Molecular & cellular oncology. vol 2. issue 2. 2016-06-16. PMID:27308426. |
in vivo analysis of the genetic determinants of myc-induced apoptosis reveals a specific requirement for the bcl2 family protein bim (bcl2l11). |
2016-06-16 |
2023-08-13 |
Not clear |
| Biswajit Chakraborty, Debasmita Dutta, Sanjukta Mukherjee, Supriya Das, Nakul C Maiti, Padma Das, Chinmay Chowdhur. Synthesis and biological evaluation of a novel betulinic acid derivative as an inducer of apoptosis in human colon carcinoma cells (HT-29). European journal of medicinal chemistry. vol 102. 2016-06-08. PMID:26248310. |
elevated level of ros generation, activation of caspase 3 and caspase 9, dna fragmentation, higher expression of bax and bad, lower expression of bcl2 and bcl-xl, and increased level of bax/bcl-xl ratio identified 2c as a promising inducer of apoptosis that follows a mitochondria dependent pathway. |
2016-06-08 |
2023-08-13 |
human |
| M Mousai, S M Hosseini, M Hajian, F Jafarpour, V Asgari, M Forouzanfar, M H Nasr-Esfahan. Effect of epigenetic modification with trichostatin A and S-adenosylhomocysteine on developmental competence and POU5F1-EGFP expression of interspecies cloned embryos in dog. Zygote (Cambridge, England). vol 23. issue 5. 2016-06-07. PMID:25314965. |
the expression levels of bcl2 and p53 were significantly affected in tsa-treated cells compared with untreated cells, whereas sah treatment had no significant effect on cell apoptosis. |
2016-06-07 |
2023-08-13 |
dog |
| Jinhua Jiang, Shenggan Wu, Yanhua Wang, Xuehua An, Leiming Cai, Xueping Zhao, Changxing W. Carbendazim has the potential to induce oxidative stress, apoptosis, immunotoxicity and endocrine disruption during zebrafish larvae development. Toxicology in vitro : an international journal published in association with BIBRA. vol 29. issue 7. 2016-06-07. PMID:26055223. |
the up-regulation of p53, apaf1, cas8 and the down-regulation of bcl2, mdm2, cas3 in the apoptosis pathway, as well as the increased expression of cytokines and chemokines, including cxcl-c1c, ccl1, il-1b, ifn, il-8, and tnfα, suggested carbendazim might trigger apoptosis and immune response during zebrafish larval development. |
2016-06-07 |
2023-08-13 |
mouse |
| Michaela Angelika Ihle, Marcel Trautmann, Helen Kuenstlinger, Sebastian Huss, Carina Heydt, Jana Fassunke, Eva Wardelmann, Sebastian Bauer, Hans-Ulrich Schildhaus, Reinhard Buettner, Sabine Merkelbach-Brus. miRNA-221 and miRNA-222 induce apoptosis via the KIT/AKT signalling pathway in gastrointestinal stromal tumours. Molecular oncology. vol 9. issue 7. 2016-06-03. PMID:25898773. |
our results demonstrate that mir-221 and mir-222 which are downregulated in wildtype and mutated gists, induce apoptosis in vitro by a signalling cascade involving kit, akt and bcl2. |
2016-06-03 |
2023-08-13 |
Not clear |
| M F Riley, M J You, A S Multani, G Lozan. Mdm2 overexpression and p73 loss exacerbate genomic instability and dampen apoptosis, resulting in B-cell lymphoma. Oncogene. vol 35. issue 3. 2016-06-03. PMID:25915849. |
b-cell lymphomas from mdm2(tg);p73(+/-) mice retain the remaining p73 allele, exhibit elevated levels of the antiapoptotic protein bcl2 and thus dampen apoptosis. |
2016-06-03 |
2023-08-13 |
mouse |
| Rekha Pal, Stephanie Green. microRNA-10b Is Overexpressed and Critical for Cell Survival and Proliferation in Medulloblastoma. PloS one. vol 10. issue 9. 2016-06-03. PMID:26394044. |
abt-737 and abt-199, potent inhibitors of bcl2, downregulated the expression of mirna-10b and increased apoptosis. |
2016-06-03 |
2023-08-13 |
Not clear |
| Yin Yang, Zongdan Wang, Luan Sun, Lipei Shao, Nan Yang, Dawei Yu, Xin Zhang, Xiao Han, Yujie Su. SATB1 Mediates Long-Range Chromatin Interactions: A Dual Regulator of Anti-Apoptotic BCL2 and Pro-Apoptotic NOXA Genes. PloS one. vol 10. issue 9. 2016-06-03. PMID:26422397. |
we previously demonstrated that satb1 mediated specific long-range chromosomal interactions between the mbr enhancer located within 3'-utr of the bcl2 gene and the promoter to regulate bcl2 expression during early apoptosis. |
2016-06-03 |
2023-08-13 |
Not clear |
| Yin Yang, Zongdan Wang, Luan Sun, Lipei Shao, Nan Yang, Dawei Yu, Xin Zhang, Xiao Han, Yujie Su. SATB1 Mediates Long-Range Chromatin Interactions: A Dual Regulator of Anti-Apoptotic BCL2 and Pro-Apoptotic NOXA Genes. PloS one. vol 10. issue 9. 2016-06-03. PMID:26422397. |
the satb1-mediated dynamic switch of the chromatin loop structures was essential for the cooperative expression of the bcl2 and noxa genes in apoptosis. |
2016-06-03 |
2023-08-13 |
Not clear |
| C Woess, S Tuzlak, V Labi, M Drach, D Bertele, P Schneider, A Villunge. Combined loss of the BH3-only proteins Bim and Bmf restores B-cell development and function in TACI-Ig transgenic mice. Cell death and differentiation. vol 22. issue 9. 2016-06-02. PMID:25698446. |
here, we show that two pro-apoptotic members of the 'bcl2 homology domain 3-only' subgroup of the bcl2 family, bcl2 interacting mediator of cell death (bim) and bcl2 modifying factor (bmf), mediate apoptosis in the context of taci-ig overexpression that effectively neutralizes baff as well as april. |
2016-06-02 |
2023-08-13 |
mouse |
| Aaron N Hata, Jeffrey A Engelman, Anthony C Fabe. The BCL2 Family: Key Mediators of the Apoptotic Response to Targeted Anticancer Therapeutics. Cancer discovery. vol 5. issue 5. 2016-06-02. PMID:25895919. |
in this review, we summarize the current knowledge of the role of bcl2 family members in cancer development and response to therapy, focusing on targeted therapeutics, recent progress in the development of apoptotic biomarkers, and therapeutic strategies designed to overcome deficiencies in apoptosis. |
2016-06-02 |
2023-08-13 |
Not clear |
| K Akahane, T Sanda, M R Mansour, T Radimerski, D J DeAngelo, D M Weinstock, A T Loo. HSP90 inhibition leads to degradation of the TYK2 kinase and apoptotic cell death in T-cell acute lymphoblastic leukemia. Leukemia. vol 30. issue 1. 2016-06-01. PMID:26265185. |
bcl2 expression was downregulated after auy922 treatment, and although this effect was necessary for auy922-induced apoptosis, it was not sufficient because many t-all cell lines were resistant to abt-199, a specific inhibitor of bcl2. |
2016-06-01 |
2023-08-13 |
Not clear |
| Gati Krushna Panigrahi, Ashish Yadav, Ashish Srivastava, Anurag Tripathi, S Raisuddin, Mukul Da. Mechanism of rhein-induced apoptosis in rat primary hepatocytes: beneficial effect of cyclosporine A. Chemical research in toxicology. vol 28. issue 6. 2016-05-31. PMID:25915446. |
at the molecular level, rhein-induced dna damage results in overexpression of γ-h2ax protein (2.5-fold), thereby causing enhancement of p53 (4.5-fold) and p21 (3.6-fold), leading to intrinsic pathway-mediated apoptosis involving bax, bcl2, cytochrome c, caspases 3 and 9, and poly-adp ribose polymerase. |
2016-05-31 |
2023-08-13 |
rat |
| Jin-Ming Li, Wei Zhang, Hua Su, Yuan-Yuan Wang, Cai-Ping Tan, Liang-Nian Ji, Zong-Wan Ma. Reversal of multidrug resistance in MCF-7/Adr cells by codelivery of doxorubicin and BCL2 siRNA using a folic acid-conjugated polyethylenimine hydroxypropyl-β-cyclodextrin nanocarrier. International journal of nanomedicine. vol 10. 2016-05-31. PMID:25960653. |
in this study, we developed a simple multifunctional nanocarrier based on polyethylenimine (pei) to codeliver doxorubicin (dox) and bcl2 small interfering rna (sirna) for overcoming multidrug resistance (mdr) and enhancing apoptosis in mcf-7/adr cancer cells by combining chemotherapy and rna interference (rnai) therapy. |
2016-05-31 |
2023-08-13 |
Not clear |
| Jin-Ming Li, Wei Zhang, Hua Su, Yuan-Yuan Wang, Cai-Ping Tan, Liang-Nian Ji, Zong-Wan Ma. Reversal of multidrug resistance in MCF-7/Adr cells by codelivery of doxorubicin and BCL2 siRNA using a folic acid-conjugated polyethylenimine hydroxypropyl-β-cyclodextrin nanocarrier. International journal of nanomedicine. vol 10. 2016-05-31. PMID:25960653. |
furthermore, the nanocomplexes achieved significant cell apoptosis through a mechanism of downregulating the antiapoptotic protein bcl2, resulted in improving therapeutic efficacy of the coadministered dox by tumor targeting and rna interference. |
2016-05-31 |
2023-08-13 |
Not clear |
| Mamdooh Ghoneum, Nouran Fel. Selective induction of apoptosis in human gastric cancer cells by Lactobacillus kefiri (PFT), a novel kefir product. Oncology reports. vol 34. issue 4. 2016-05-20. PMID:26251956. |
apoptosis is associated with the decreased polarization of mitochondrial membrane potential (mmp) and decreased bcl2 expression. |
2016-05-20 |
2023-08-13 |
human |
| Georgios I Karaliotas, Konstantinos Mavridis, Andreas Scorilas, George C Babi. Quantitative analysis of the mRNA expression levels of BCL2 and BAX genes in human osteoarthritis and normal articular cartilage: An investigation into their differential expression. Molecular medicine reports. vol 12. issue 3. 2016-05-17. PMID:26081683. |
although the role of apoptosis in cartilage pathobiology remains to be elucidated, the apoptotic b‑cell cll/lymphoma 2 (bcl2) gene family is considered to be involved in oa. |
2016-05-17 |
2023-08-13 |
human |
| Georgios I Karaliotas, Konstantinos Mavridis, Andreas Scorilas, George C Babi. Quantitative analysis of the mRNA expression levels of BCL2 and BAX genes in human osteoarthritis and normal articular cartilage: An investigation into their differential expression. Molecular medicine reports. vol 12. issue 3. 2016-05-17. PMID:26081683. |
these results further implicate apoptosis in the pathogenesis of oa, through molecular mechanisms, which include the aberrant expression of the bcl2 gene family. |
2016-05-17 |
2023-08-13 |
human |
| Xiao-E Jia, Ke Ma, Tao Xu, Lei Gao, Shuang Wu, Cong Fu, Wenjuan Zhang, Zhizhang Wang, Kaiyu Liu, Mei Dong, Changbin Jing, Chunguang Ren, Zhiwei Dong, Yi Chen, Yi Jin, Qiuhua Huang, Xing Chang, Min Deng, Li Li, Lingfei Luo, Jun Zhu, Yongjun Dang, Hung-Chun Chang, Leonard I Zon, Yi Zhou, Saijuan Chen, Weijun Pa. Mutation of kri1l causes definitive hematopoiesis failure via PERK-dependent excessive autophagy induction. Cell research. vol 25. issue 8. 2016-05-17. PMID:26138676. |
blocking autophagy but not inhibiting apoptosis by bcl2 overexpression can fully rescue hematopoietic defects, but not the lethality of kri1l(cas002) embryos. |
2016-05-17 |
2023-08-13 |
human |