| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ya-Ling Chang, Bing-Ching Ho, Singh Sher, Sung-Liang Yu, Pan-Chyr Yan. miR-146a and miR-370 coordinate enterovirus 71-induced cell apoptosis through targeting SOS1 and GADD45β. Cellular microbiology. vol 17. issue 6. 2016-02-01. PMID:25469565. |
we identified two major apoptosis-associated signalling pathways, bcl2 antagonist of cell death (bad) phosphorylation and p53-dependent apoptosis pathways, in which son of sevenless homolog 1 (sos1) and growth arrest and dna damage-inducible protein 45β (gadd45β) were predicted as targets of mir-146a and mir-370 respectively. |
2016-02-01 |
2023-08-13 |
Not clear |
| Yun Dai, Steven Gran. BCL2L11/Bim as a dual-agent regulating autophagy and apoptosis in drug resistance. Autophagy. vol 11. issue 2. 2016-01-26. PMID:25700997. |
it is recognized that autophagy and apoptosis share molecular regulatory mechanisms primarily governed by multidomain anti-apoptotic members (e.g., bcl2/bcl(-)2 and bcl2l1/bcl(-)xl) of the bcl2 family. |
2016-01-26 |
2023-08-13 |
Not clear |
| Bilal Rah, Reyaz ur Rasool, Debasis Nayak, Syed Khalid Yousuf, Debaraj Mukherjee, Lekha Dinesh Kumar, Anindya Goswam. PAWR-mediated suppression of BCL2 promotes switching of 3-azido withaferin A (3-AWA)-induced autophagy to apoptosis in prostate cancer cells. Autophagy. vol 11. issue 2. 2016-01-26. PMID:25803782. |
pawr-mediated suppression of bcl2 promotes switching of 3-azido withaferin a (3-awa)-induced autophagy to apoptosis in prostate cancer cells. |
2016-01-26 |
2023-08-13 |
Not clear |
| Bilal Rah, Reyaz ur Rasool, Debasis Nayak, Syed Khalid Yousuf, Debaraj Mukherjee, Lekha Dinesh Kumar, Anindya Goswam. PAWR-mediated suppression of BCL2 promotes switching of 3-azido withaferin A (3-AWA)-induced autophagy to apoptosis in prostate cancer cells. Autophagy. vol 11. issue 2. 2016-01-26. PMID:25803782. |
second, higher toxic concentrations of 3-awa stimulated er stress in cap cells to turn on apoptosis within 12 h by elevating the expression of the proapoptotic protein pawr, which in turn suppressed the autophagy-related proteins bcl2 and becn1. |
2016-01-26 |
2023-08-13 |
Not clear |
| Anuradha Cingeetham, Sugunakar Vuree, Nageswara Rao Dunna, Manjula Gorre, Santhoshi Rani Nanchari, Prajitha Mohandas Edathara, Phannibhushann Meka, Sandhya Annamaneni, Raghunadharao Digumarthi, Sudha Sinha, Vishnupriya Satt. Influence of BCL2-938C>A and BAX-248G>A promoter polymorphisms in the development of AML: case-control study from South India. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 36. issue 10. 2016-01-26. PMID:25957891. |
b-cell lymphoma 2 (bcl2) and bcl2-associated x protein (bax) proteins are anti-apoptotic and pro-apoptotic determinants of mitochondrial-mediated apoptosis, and their relative expression determines the cell fate. |
2016-01-26 |
2023-08-13 |
Not clear |
| Jie Chen, Jinsong Zhou, Xin Chen, Baohui Yang, Dong Wang, Pinglin Yang, Xijing He, Haopeng L. miRNA-449a is downregulated in osteosarcoma and promotes cell apoptosis by targeting BCL2. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 36. issue 10. 2016-01-26. PMID:26002578. |
mirna-449a is downregulated in osteosarcoma and promotes cell apoptosis by targeting bcl2. |
2016-01-26 |
2023-08-13 |
Not clear |
| Joanna L Fox, Alan Store. BMX Negatively Regulates BAK Function, Thereby Increasing Apoptotic Resistance to Chemotherapeutic Drugs. Cancer research. vol 75. issue 7. 2016-01-23. PMID:25649765. |
intrinsic apoptosis, regulated by the bcl2 family, integrates diverse apoptotic signals to determine cell death commitment and then activates the nodal effector protein bak to initiate the apoptotic cascade. |
2016-01-23 |
2023-08-13 |
Not clear |
| Xingjie Ma, Minlu Huang, Zhenqiang Wang, Bingya Liu, Zhenggang Zhu, Chen L. ZHX1 Inhibits Gastric Cancer Cell Growth through Inducing Cell-Cycle Arrest and Apoptosis. Journal of Cancer. vol 7. issue 1. 2016-01-01. PMID:26722361. |
zhx1 induced g1/s arrest by decreasing cyclin d1 and cyclin e expression, and induced cell apoptosis by bcl2 downregulation and bax and cleaved caspase-3 upregulation. |
2016-01-01 |
2023-08-13 |
human |
| Yingying Feng, Xiaojie Xu, Yunjing Zhang, Jianhua Ding, Yonggang Wang, Xiaopeng Zhang, Zhe Wu, Lei Kang, Yingchun Liang, LiYing Zhou, Santai Song, Ke Zhao, Qinong Y. HPIP is upregulated in colorectal cancer and regulates colorectal cancer cell proliferation, apoptosis and invasion. Scientific reports. vol 5. 2015-12-30. PMID:25800793. |
hpip inhibits crc cell apoptosis accompanied by the decreased levels of bax and pig3, the inducers of apoptosis, and the increased level of the apoptosis inhibitor bcl2. |
2015-12-30 |
2023-08-13 |
mouse |
| Y Kuwano, K Nishida, K Kajita, Y Satake, Y Akaike, K Fujita, S Kano, K Masuda, K Rokuta. Transformer 2β and miR-204 regulate apoptosis through competitive binding to 3' UTR of BCL2 mRNA. Cell death and differentiation. vol 22. issue 5. 2015-12-24. PMID:25342468. |
transformer 2β and mir-204 regulate apoptosis through competitive binding to 3' utr of bcl2 mrna. |
2015-12-24 |
2023-08-13 |
human |
| Mariarosa Mazza, Marilena Hadjidemetriou, Irene de Lázaro, Cyrill Bussy, Kostas Kostarelo. Peptide nanofiber complexes with siRNA for deep brain gene silencing by stereotactic neurosurgery. ACS nano. vol 9. issue 2. 2015-12-21. PMID:25574683. |
the biological activity of the complexes was investigated in vitro by analyzing the down-regulation of the expression of a targeted protein (bcl2), as well as induction of apoptosis, as well as in vivo by analyzing the relative gene expression upon stereotactic administration into a deep rat brain structure (the subthalamic nucleus). |
2015-12-21 |
2023-08-13 |
rat |
| Baohua Sun, Bhavin Shah, Warren Fiskus, Jun Qi, Kimal Rajapakshe, Cristian Coarfa, Li Li, Santhana G T Devaraj, Sunil Sharma, Liang Zhang, Michael L Wang, Dyana T Saenz, Stephanie Krieger, James E Bradner, Kapil N Bhall. Synergistic activity of BET protein antagonist-based combinations in mantle cell lymphoma cells sensitive or resistant to ibrutinib. Blood. vol 126. issue 13. 2015-12-21. PMID:26254443. |
ba treatment also induced apoptosis of the in vitro isolated, ibrutinib-resistant mcl cells, which overexpress cdk6, bcl2, bcl-xl, xiap, and akt, but lack ibrutinib resistance-conferring btk mutation. |
2015-12-21 |
2023-08-13 |
mouse |
| Baohua Sun, Bhavin Shah, Warren Fiskus, Jun Qi, Kimal Rajapakshe, Cristian Coarfa, Li Li, Santhana G T Devaraj, Sunil Sharma, Liang Zhang, Michael L Wang, Dyana T Saenz, Stephanie Krieger, James E Bradner, Kapil N Bhall. Synergistic activity of BET protein antagonist-based combinations in mantle cell lymphoma cells sensitive or resistant to ibrutinib. Blood. vol 126. issue 13. 2015-12-21. PMID:26254443. |
cotreatment with ba and panobinostat (pan-histone deacetylase inhibitor) or palbociclib (cdk4/6 inhibitor) or abt-199 (bcl2 antagonist) synergistically induced apoptosis of the ibrutinib-resistant mcl cells. |
2015-12-21 |
2023-08-13 |
mouse |
| Joung Hyuck Joo, Eiichiro Ueda, Carl D Bortner, Xiao-Ping Yang, Grace Liao, Anton M Jette. Farnesol activates the intrinsic pathway of apoptosis and the ATF4-ATF3-CHOP cascade of ER stress in human T lymphoblastic leukemia Molt4 cells. Biochemical pharmacology. vol 97. issue 3. 2015-12-21. PMID:26275811. |
the induction of apoptosis by farnesol was inhibited by the addition of the pan-caspase inhibitor z-vad-fmk and by the exogenous expression of the anti-apoptotic protein bcl2. |
2015-12-21 |
2023-08-13 |
human |
| Jong Hye Cheong, Hyeryung Kim, Min Jee Hong, Min Hye Yang, Jung Wha Kim, Hunseung Yoo, Heejung Yang, Jeong Hill Park, Sang Hyun Sung, Hong Pyo Kim, Jinwoong Ki. Stereoisomer-specific anticancer activities of ginsenoside Rg3 and Rh2 in HepG2 cells: disparity in cytotoxicity and autophagy-inducing effects due to 20(S)-epimers. Biological & pharmaceutical bulletin. vol 38. issue 1. 2015-12-15. PMID:25744465. |
the 20(s)-forms of rg3 and rh2, but not their respective 20(r)-forms, promoted cell death in a dose-dependent manner accompanied by downregulation of bcl2 and upregulation of fas, resulting in apoptosis of hepg2 cells with poly adp ribose polymerase cleavage. |
2015-12-15 |
2023-08-13 |
Not clear |
| Mehboob Ali, Kathryn M Heyob, Markus Velten, Trent E Tipple, Lynette K Roger. DHA suppresses chronic apoptosis in the lung caused by perinatal inflammation. American journal of physiology. Lung cellular and molecular physiology. vol 309. issue 5. 2015-12-15. PMID:26138643. |
we detected substantial increases in markers of apoptosis including parp-1, apaf-1, caspase-9, bcl2, and hmgb1, and these increases were attenuated in mice that were nursed by dha-supplemented dams during the perinatal period. |
2015-12-15 |
2023-08-13 |
mouse |
| Ju Hee Oh, Jae Yoon Lee, Jin Hyeong Park, Jeong Hyeon No, Na Kyung Le. Obatoclax regulates the proliferation and fusion of osteoclast precursors through the inhibition of ERK activation by RANKL. Molecules and cells. vol 38. issue 3. 2015-12-14. PMID:25666350. |
bcl2-deficient mice have shown the importance of bcl2 in osteoclasts, as the bone mass of the mice was increased by the induced apoptosis of osteoclasts. |
2015-12-14 |
2023-08-13 |
mouse |
| Waseem Ahmad Siddiqui, Amjid Ahad, Haseeb Ahsa. The mystery of BCL2 family: Bcl-2 proteins and apoptosis: an update. Archives of toxicology. vol 89. issue 3. 2015-12-01. PMID:25618543. |
the mystery of bcl2 family: bcl-2 proteins and apoptosis: an update. |
2015-12-01 |
2023-08-13 |
Not clear |
| Varda Shoshan-Barmatz, Danya Ben-Hail, Lee Admoni, Yakov Krelin, Shambhoo Sharan Tripath. The mitochondrial voltage-dependent anion channel 1 in tumor cells. Biochimica et biophysica acta. vol 1848. issue 10 Pt B. 2015-11-24. PMID:25448878. |
apoptosis can also be regulated by vdac1, serving as an anchor point for mitochondria-interacting proteins, such as hexokinase (hk), bcl2 and bcl-xl, some of which are also highly expressed in many cancers. |
2015-11-24 |
2023-08-13 |
Not clear |
| L Li, P Pongtornpipat, T Tiutan, S L Kendrick, S Park, D O Persky, L M Rimsza, S D Puvvada, J H Schat. Synergistic induction of apoptosis in high-risk DLBCL by BCL2 inhibition with ABT-199 combined with pharmacologic loss of MCL1. Leukemia. vol 29. issue 8. 2015-11-05. PMID:25882699. |
synergistic induction of apoptosis in high-risk dlbcl by bcl2 inhibition with abt-199 combined with pharmacologic loss of mcl1. |
2015-11-05 |
2023-08-13 |
Not clear |