| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L Li, P Pongtornpipat, T Tiutan, S L Kendrick, S Park, D O Persky, L M Rimsza, S D Puvvada, J H Schat. Synergistic induction of apoptosis in high-risk DLBCL by BCL2 inhibition with ABT-199 combined with pharmacologic loss of MCL1. Leukemia. vol 29. issue 8. 2015-11-05. PMID:25882699. |
avoiding apoptosis is a hallmark of cancer, and in dlbcl the redundantly functioning antiapoptotic proteins bcl2 and mcl1 are frequently expressed. |
2015-11-05 |
2023-08-13 |
Not clear |
| L Li, P Pongtornpipat, T Tiutan, S L Kendrick, S Park, D O Persky, L M Rimsza, S D Puvvada, J H Schat. Synergistic induction of apoptosis in high-risk DLBCL by BCL2 inhibition with ABT-199 combined with pharmacologic loss of MCL1. Leukemia. vol 29. issue 8. 2015-11-05. PMID:25882699. |
dinaciclib induces apoptosis in dlbcl cells but is completely overcome by increased activity of bcl2. |
2015-11-05 |
2023-08-13 |
Not clear |
| Ki Bbeum Kim, Karam Kim, Seunghee Bae, Yeonghmin Choi, Hwa Jun Cha, Soo Yeon Kim, Jae Ho Lee, So Hyeon Jeon, Ho Jung Jung, Kyu Joong Ahn, In-Sook An, Sungkwan A. MicroRNA-1290 promotes asiatic acid‑induced apoptosis by decreasing BCL2 protein level in A549 non‑small cell lung carcinoma cells. Oncology reports. vol 32. issue 3. 2015-11-03. PMID:25016979. |
microrna-1290 promotes asiatic acid‑induced apoptosis by decreasing bcl2 protein level in a549 non‑small cell lung carcinoma cells. |
2015-11-03 |
2023-08-13 |
Not clear |
| Justin M M Cates, Vincent A Memoli, Raul S Gonzale. Cell cycle and apoptosis regulatory proteins, proliferative markers, cell signaling molecules, CD209, and decorin immunoreactivity in low-grade myxofibrosarcoma and myxoma. Virchows Archiv : an international journal of pathology. vol 467. issue 2. 2015-11-03. PMID:25940995. |
ten cases each of intramuscular myxoma and low-grade myxofibrosarcoma were stained with antibodies directed against apoptosis regulatory proteins (bcl2, activated caspase-3, phospho-h2a.x, and cleaved parp), cell cycle regulatory proteins (rb1, cyclin-a, cdkn1b, and cdt1), proliferative markers (ki67, mcm2, phospho-histone h3, and geminin), cell signalling molecules (c-myc, egf, egfr, pla2g4a, and hsp90), a dendritic cell marker (cd209), and the extracellular matrix proteoglycan decorin. |
2015-11-03 |
2023-08-13 |
Not clear |
| Olatz Landeta, Ane Landajuela, Ana Garcia-Saez, Gorka Basañe. Minimalist Model Systems Reveal Similarities and Differences between Membrane Interaction Modes of MCL1 and BAK. The Journal of biological chemistry. vol 290. issue 27. 2015-10-26. PMID:25987560. |
proteins belonging to the bcl2 family are key modulators of apoptosis that establish a complex network of interactions among themselves and with other cellular factors to regulate cell fate. |
2015-10-26 |
2023-08-13 |
Not clear |
| Olatz Landeta, Ane Landajuela, Ana Garcia-Saez, Gorka Basañe. Minimalist Model Systems Reveal Similarities and Differences between Membrane Interaction Modes of MCL1 and BAK. The Journal of biological chemistry. vol 290. issue 27. 2015-10-26. PMID:25987560. |
it is well established that mitochondrial membranes are the main locus of action of all bcl2 family proteins, but it is difficult to obtain a precise view of how bcl2 family members operate at the native mitochondrial membrane environment during apoptosis. |
2015-10-26 |
2023-08-13 |
Not clear |
| Niklas Gebauer, Veronica Bernard, Wolfgang Gebauer, Christoph Thorns, Alfred C Feller, Hartmut Mer. TP53 mutations are frequent events in double-hit B-cell lymphomas with MYC and BCL2 but not MYC and BCL6 translocations. Leukemia & lymphoma. vol 56. issue 1. 2015-10-07. PMID:24679006. |
our findings indicate a significant difference between these two types of dhl at a molecular level with pathogenetic implications, as arguably, tp53 mutations inhibiting p53 mediated promotion of apoptosis pose a synergistic advantage in clonal evolution of cells with malignantly enforced overexpression of bcl2. |
2015-10-07 |
2023-08-12 |
Not clear |
| Swati Mandal, Ajeet Mandal, Myung Hee Par. Depletion of the polyamines spermidine and spermine by overexpression of spermidine/spermine N¹-acetyltransferase 1 (SAT1) leads to mitochondria-mediated apoptosis in mammalian cells. The Biochemical journal. vol 468. issue 3. 2015-10-06. PMID:25849284. |
apoptosis in the polyamine-depleted cells occurs by the mitochondrial intrinsic pathway, as evidenced by loss of mitochondrial membrane potential, increase in pro-apoptotic bax, decrease in anti-apoptotic bcl-xl, bcl2 and mcl-1 and release of cytochrome c from mitochondria, upon transduction with adsat1. |
2015-10-06 |
2023-08-13 |
human |
| Paolo Convertini, Francesco Tramutola, Vito Iacobazzi, Paolo Lupattelli, Lucia Chiummiento, Vittoria Infantin. Permethylated Anigopreissin A inhibits human hepatoma cell proliferation by mitochondria-induced apoptosis. Chemico-biological interactions. vol 237. 2015-10-06. PMID:25980588. |
decrease of the bcl2 expression levels, loss of the mitochondrial membrane potential, release of cytochrome c and increase of caspase 9 activity highlight a key role for mitochondria in permethylated anigopreissin a-induced apoptosis. |
2015-10-06 |
2023-08-13 |
human |
| Ishwari Kadariya, Jiaxing Wang, Zia ur Rehman, Hamid Ali, Hasan Riaz, JiuYa He, Dinesh Bhattarai, Jia Jia Liu, Shu Jun Zhan. RNAi-mediated knockdown of inhibin α subunit increased apoptosis in granulosa cells and decreased fertility in mice. The Journal of steroid biochemistry and molecular biology. vol 152. 2015-10-06. PMID:25998417. |
furthermore, suppression of inhα expression significantly promoted apoptosis by up-regulating caspase-3, bcl2, inhβb and gdf9 and down regulated kitl and tgfβriii genes both at transcriptional and translational levels. |
2015-10-06 |
2023-08-13 |
mouse |
| Phil Jun Lee, Seung Je Woo, Jun-Goo Jee, Sang Hyun Sung, Hong Pyo Ki. Bisdemethoxycurcumin Induces apoptosis in activated hepatic stellate cells via cannabinoid receptor 2. Molecules (Basel, Switzerland). vol 20. issue 1. 2015-10-02. PMID:25594342. |
bdmc-induced apoptosis was mediated by a combinatory inhibition of cytoprotective proteins, such as bcl2 and heme oxygenase-1 and increased generation of reactive oxygen species. |
2015-10-02 |
2023-08-13 |
Not clear |
| Weiming He, Yingfu Li, Jingyan Tian, Ning Jiang, Bo Du, Yuping Pen. Optimized mixture of As, Cd and Pb induce mitochondria-mediated apoptosis in C6-glioma via astroglial activation, inflammation and P38-MAPK. American journal of cancer research. vol 5. issue 8. 2015-09-23. PMID:26396915. |
an increase in pro-apoptotic bcl-2-associated-x protein (bax) and decrease in anti-apoptotic bcl2 resulting in a bax/bcl2 ratio > 1.0 validated mitochondrial apoptosis. |
2015-09-23 |
2023-08-13 |
rat |
| Yang Cao, Guang Yang, Zachary R Hunter, Xia Liu, Lian Xu, Jie Chen, Nickolas Tsakmaklis, Evdoxia Hatjiharissi, Sandra Kanan, Matthew S Davids, Jorge J Castillo, Steven P Treo. The BCL2 antagonist ABT-199 triggers apoptosis, and augments ibrutinib and idelalisib mediated cytotoxicity in CXCR4 Wild-type and CXCR4 WHIM mutated Waldenstrom macroglobulinaemia cells. British journal of haematology. vol 170. issue 1. 2015-09-21. PMID:25582069. |
the bcl2 antagonist abt-199 triggers apoptosis, and augments ibrutinib and idelalisib mediated cytotoxicity in cxcr4 wild-type and cxcr4 whim mutated waldenstrom macroglobulinaemia cells. |
2015-09-21 |
2023-08-13 |
Not clear |
| Qing He, Jinyun Tan, Bo Yu, Weihao Shi, Kun Lian. Long noncoding RNA HIF1A-AS1A reduces apoptosis of vascular smooth muscle cells: implications for the pathogenesis of thoracoabdominal aorta aneurysm. Die Pharmazie. vol 70. issue 5. 2015-09-21. PMID:26062299. |
we also found that transfection of cells with hif1a-as1 sirna decreased the expression of caspase-3 and caspase-8 and increased the expression of bcl2, and protected pa-induced cell apoptosis in vsmcs. |
2015-09-21 |
2023-08-13 |
Not clear |
| Hiroko P Indo, Tsukasa Tomiyoshi, Shigeaki Suenaga, Kazuo Tomita, Hiromi Suzuki, Daisuke Masuda, Masahiro Terada, Noriaki Ishioka, Oleg Gusev, Richard Cornette, Takashi Okuda, Chiaki Mukai, Hideyuki J Majim. MnSOD downregulation induced by extremely low 0.1 mGy single and fractionated X-rays and microgravity treatment in human neuroblastoma cell line, NB-1. Journal of clinical biochemistry and nutrition. vol 57. issue 2. 2015-09-21. PMID:26388666. |
a quantitative real-time reverse transcription polymerase chain reaction (qrt-pcr) examination was performed for apoptosis related factors (bax, cytc, apaf1, vdac1-3, casp3, casp8, casp9 p53, aif, ant1 and 2, bcl2, mnsod, autophagy related becn and necrosis related cyp-40. |
2015-09-21 |
2023-08-13 |
human |
| Suhas V Vasaikar, Sourish Ghosh, Priyam Narain, Anirban Basu, James Gome. HSP70 mediates survival in apoptotic cells-Boolean network prediction and experimental validation. Frontiers in cellular neuroscience. vol 9. 2015-09-18. PMID:26379495. |
further, the pro-survival role of the proteins bcl2, iap, cflip, and nfκb determined by vertex perturbation analysis was experimentally validated through protein inhibition experiments using em20-25, embelin and wedelolactone, which resulted in 1.27-, 1.26-, and 1.46-fold increase in apoptosis of n2a cells. |
2015-09-18 |
2023-08-13 |
Not clear |
| Nathalie Allaman-Pillet, Anne Oberson, Daniel F Schordere. BIRO1, a cell-permeable BH3 peptide, promotes mitochondrial fragmentation and death of retinoblastoma cells. Molecular cancer research : MCR. vol 13. issue 1. 2015-09-16. PMID:25143432. |
the bh3-only proteins promote apoptosis by modulating the interaction between the pro- and antiapoptotic members of the bcl2 protein family, and this effect can be recapitulated by the bh3 domains. |
2015-09-16 |
2023-08-13 |
Not clear |
| K Chitta, A Paulus, T R Caulfield, S Akhtar, M-K K Blake, S Ailawadhi, J Knight, M G Heckman, A Pinkerton, A Chanan-Kha. Nimbolide targets BCL2 and induces apoptosis in preclinical models of Waldenströms macroglobulinemia. Blood cancer journal. vol 4. 2015-09-16. PMID:25382610. |
nimbolide targets bcl2 and induces apoptosis in preclinical models of waldenströms macroglobulinemia. |
2015-09-16 |
2023-08-13 |
mouse |
| K Chitta, A Paulus, T R Caulfield, S Akhtar, M-K K Blake, S Ailawadhi, J Knight, M G Heckman, A Pinkerton, A Chanan-Kha. Nimbolide targets BCL2 and induces apoptosis in preclinical models of Waldenströms macroglobulinemia. Blood cancer journal. vol 4. 2015-09-16. PMID:25382610. |
the significance of this finding was further tested in vitro in rs4;11 (bcl2-dependent) tumor cells, in which nimbolide induced significantly more apoptosis compared with bcl2 mutated (jurkat bcl2(ser70-ala)) cells. |
2015-09-16 |
2023-08-13 |
mouse |
| Anne Benard, Connie M Janssen, Peter J van den Elsen, Marja C J A van Eggermond, Dave S B Hoon, Cornelis J H van de Velde, Peter J K Kuppe. Chromatin status of apoptosis genes correlates with sensitivity to chemo-, immune- and radiation therapy in colorectal cancer cell lines. Apoptosis : an international journal on programmed cell death. vol 19. issue 12. 2015-09-14. PMID:25292014. |
using chromatin immunoprecipitation (chip), we measured the presence of transcription-activating histone modifications h3ac and h3k4me3 and silencing modifications h3k9me3 and h3k27me3 at the gene promoter regions of key apoptosis genes bax, bcl2, caspase-9, fas (cd95) and p53. |
2015-09-14 |
2023-08-13 |
Not clear |