| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiao-E Jia, Ke Ma, Tao Xu, Lei Gao, Shuang Wu, Cong Fu, Wenjuan Zhang, Zhizhang Wang, Kaiyu Liu, Mei Dong, Changbin Jing, Chunguang Ren, Zhiwei Dong, Yi Chen, Yi Jin, Qiuhua Huang, Xing Chang, Min Deng, Li Li, Lingfei Luo, Jun Zhu, Yongjun Dang, Hung-Chun Chang, Leonard I Zon, Yi Zhou, Saijuan Chen, Weijun Pa. Mutation of kri1l causes definitive hematopoiesis failure via PERK-dependent excessive autophagy induction. Cell research. vol 25. issue 8. 2016-05-17. PMID:26138676. |
blocking autophagy but not inhibiting apoptosis by bcl2 overexpression can fully rescue hematopoietic defects, but not the lethality of kri1l(cas002) embryos. |
2016-05-17 |
2023-08-13 |
human |
| Ji Ma, Shaofeng Shui, Xinwei Han, Dong Guo, Tengfei Li, Lei Ya. microRNA-22 attenuates neuronal cell apoptosis in a cell model of traumatic brain injury. American journal of translational research. vol 8. issue 4. 2016-05-17. PMID:27186313. |
the activity of caspase 3 (casp3) and level changes of several apoptosis factors including b-cell lymphoma 2 (bcl2), bcl2-associated x protein (bax), phosphatase and tensin homolog (pten) and v-akt murine thymoma viral oncogene homolog 1 (akt1) were detected. |
2016-05-17 |
2023-08-13 |
rat |
| Ji Ma, Shaofeng Shui, Xinwei Han, Dong Guo, Tengfei Li, Lei Ya. microRNA-22 attenuates neuronal cell apoptosis in a cell model of traumatic brain injury. American journal of translational research. vol 8. issue 4. 2016-05-17. PMID:27186313. |
it also caused the corresponding changes in casp3 activity and other apoptosis factors, with cleaved casp3, bax and pten inhibited and bcl2 and phosphorylated akt1 promoted, while mir-22 antagomir had the opposite effects. |
2016-05-17 |
2023-08-13 |
rat |
| Ko-Woon Choi, Hyewon Suh, Ha Lim Oh, Chongsuk Ryou, Chul-Hoon Le. p21CIP1 Induces Apoptosis via Binding to BCL2 in LNCaP Prostate Cancer Cells Treated with MCS-C3, A Novel Carbocyclic Analog of Pyrrolopyrimidine. Anticancer research. vol 36. issue 1. 2016-05-11. PMID:26722046. |
p21cip1 induces apoptosis via binding to bcl2 in lncap prostate cancer cells treated with mcs-c3, a novel carbocyclic analog of pyrrolopyrimidine. |
2016-05-11 |
2023-08-13 |
Not clear |
| Ernest Milián, Eva Prats, Jordi J Cairó, Francesc Gòdia, Joaquim Vive. BHRF1 exerts an antiapoptotic effect and cell cycle arrest via Bcl-2 in murine hybridomas. Journal of biotechnology. vol 209. 2016-05-04. PMID:26057602. |
remarkably, the expression of the anti-apoptotic gene bcl2 in bhrf1-expressing cells was up-regulated 25-fold compared to mock-transfected controls under apoptosis triggering conditions and its expression correlated with survival of transgenic cultures and cell cycle arrest in g1. |
2016-05-04 |
2023-08-13 |
Not clear |
| Tijana Knezevic, Valerie D Myers, Jennifer Gordon, Douglas G Tilley, Thomas E Sharp, JuFang Wang, Kamel Khalili, Joseph Y Cheung, Arthur M Feldma. BAG3: a new player in the heart failure paradigm. Heart failure reviews. vol 20. issue 4. 2016-05-03. PMID:25925243. |
bag3 functions in the cell include: serving as a co-chaperone with members of the heat-shock protein family of proteins to facilitate the removal of misfolded and degraded proteins, inhibiting apoptosis by interacting with bcl2 and maintaining the structural integrity of the z-disk in muscle by binding with capz. |
2016-05-03 |
2023-08-13 |
mouse |
| Decui Shao, Jun Ni, Yang Shen, Jia Liu, Li Zhou, Hong Xue, Yu Huang, Wei Zhang, Limin L. CHOP mediates XBP1S-induced renal mesangial cell necrosis following high glucose treatment. European journal of pharmacology. vol 758. 2016-04-26. PMID:25857226. |
apoptosis and necrosis were quantified by flow cytometry; protein levels of xbp1s, caspase3, bax, bcl2, bnip3, and chop were analyzed by western blotting. |
2016-04-26 |
2023-08-13 |
Not clear |
| A Baumgarten, J Finke, R Mark. [Current diagnostics and therapy of B cell Non Hodgkin Lymphoma]. Therapeutische Umschau. Revue therapeutique. vol 69. issue 10. 2016-04-23. PMID:23026882. |
cases with follicular lymphoma very often show the t(14; 18) translocation resulting in overexpression of bcl2 and diminished apoptosis. |
2016-04-23 |
2023-08-12 |
Not clear |
| Ming Liu, Yumei Chen, Guixian Song, Bin Chen, Lihua Wang, Xing Li, Xiangqing Kong, Yahui Shen, Lingmei Qia. MicroRNA-29c overexpression inhibits proliferation and promotes apoptosis and differentiation in P19 embryonal carcinoma cells. Gene. vol 576. issue 1 Pt 2. 2016-04-21. PMID:26484393. |
we evaluated proliferation and cell cycle progression, detected morphological changes; apoptosis rate; bax, bcl2, gata binding protein 4 (gata4), cardiac troponin t (ctnt), and myocyte enhancer factor 2c (mef2c) expression; and caspase-3, -8, and -9 activity in mir-29c-overexpressing p19 cells, and investigated whether wnt4 was a mir-29c target. |
2016-04-21 |
2023-08-13 |
Not clear |
| b' Xenia Villalobos, Laura Rodr\\xc3\\xadguez, Anna Sol\\xc3\\xa9, Carolina Lliber\\xc3\\xb3s, N\\xc3\\xbaria Mencia, Carlos J Ciudad, V\\xc3\\xa9ronique No\\xc3\\xa. Effect of Polypurine Reverse Hoogsteen Hairpins on Relevant Cancer Target Genes in Different Human Cell Lines. Nucleic acid therapeutics. vol 25. issue 4. 2016-04-15. PMID:26042602.' |
we designed pprhs against the following genes: bcl2, top1, mtor, mdm2, and myc and tested them for mrna levels, cytotoxicity, and apoptosis in prostate, pancreas, colon, and breast cancer cell lines. |
2016-04-15 |
2023-08-13 |
human |
| b' Xenia Villalobos, Laura Rodr\\xc3\\xadguez, Anna Sol\\xc3\\xa9, Carolina Lliber\\xc3\\xb3s, N\\xc3\\xbaria Mencia, Carlos J Ciudad, V\\xc3\\xa9ronique No\\xc3\\xa. Effect of Polypurine Reverse Hoogsteen Hairpins on Relevant Cancer Target Genes in Different Human Cell Lines. Nucleic acid therapeutics. vol 25. issue 4. 2016-04-15. PMID:26042602.' |
even though all pprhs were effective, the most remarkable results were obtained with those against bcl2 and mammalian target of rapamycin (mtor) in decreasing cell survival and mrna levels and increasing apoptosis in prostate, colon, and pancreatic cancer cells. |
2016-04-15 |
2023-08-13 |
human |
| b' Xenia Villalobos, Laura Rodr\\xc3\\xadguez, Anna Sol\\xc3\\xa9, Carolina Lliber\\xc3\\xb3s, N\\xc3\\xbaria Mencia, Carlos J Ciudad, V\\xc3\\xa9ronique No\\xc3\\xa. Effect of Polypurine Reverse Hoogsteen Hairpins on Relevant Cancer Target Genes in Different Human Cell Lines. Nucleic acid therapeutics. vol 25. issue 4. 2016-04-15. PMID:26042602.' |
thus, we confirm that the pprh technology is broadly useful to silence the expression of cancer-related genes as demonstrated using target genes involved in metabolism (dhfr), proliferation (mtor), dna topology (top1), lifespan and senescence (telomerase), apoptosis (survivin, bcl2), transcription factors (myc), and proto-oncogenes (mdm2). |
2016-04-15 |
2023-08-13 |
human |
| Yun-Jung Lee, Conglin Liu, Mengyang Liao, Galina K Sukhova, Jun Shirakawa, Meriem Abdennour, Karine Iamarene, Sebastien Andre, Karen Inouye, Karine Clement, Rohit N Kulkarni, Alexander S Banks, Peter Libby, Guo-Ping Sh. Deficiency of FcϵR1 Increases Body Weight Gain but Improves Glucose Tolerance in Diet-Induced Obese Mice. Endocrinology. vol 156. issue 11. 2016-04-12. PMID:26295369. |
white adipose tissue from fcer1a(-/-) mice showed an increased expression of phospho-akt, ccaat/enhancer binding protein-α, peroxisome proliferator-activated receptor-γ, glucose transporter-4 (glut4), and b-cell lymphoma 2 (bcl2) but reduced uncoupling protein 1 (ucp1) and phosphorylated c-jun n-terminal kinase (jnk) expression, tissue macrophage accumulation, and apoptosis, suggesting that ige reduces adipogenesis and glucose uptake but induces energy expenditure, adipocyte apoptosis, and white adipose tissue inflammation. |
2016-04-12 |
2023-08-13 |
mouse |
| Yunxia Tang, Qiongshu Li, Fanwei Meng, Xingyu Huang, Chan Li, Xin Zhou, Xiaoping Zeng, Yixin He, Jia Liu, Xiang Hu, Ji-Fan Hu, Tao L. Therapeutic Potential of HGF-Expressing Human Umbilical Cord Mesenchymal Stem Cells in Mice with Acute Liver Failure. International journal of hepatology. vol 2016. 2016-04-08. PMID:27057357. |
additionally, hgf-ucmscs modulated apoptosis by upregulating the antiapoptotic bcl2 and downregulating proapoptotic genes, including bax and tnfα. |
2016-04-08 |
2023-08-13 |
mouse |
| Danmin Huang, Wenjie Guo, Jing Gao, Jun Chen, Joshua Opeyemi Olatunj. Clinacanthus nutans (Burm. f.) Lindau Ethanol Extract Inhibits Hepatoma in Mice through Upregulation of the Immune Response. Molecules (Basel, Switzerland). vol 20. issue 9. 2016-04-05. PMID:26393569. |
western blot analysis of papr, caspase-3, bax, and bcl2 also showed that cn30 induced apoptosis in hepatoma cells. |
2016-04-05 |
2023-08-13 |
mouse |
| Sourabh Dwivedi, Quaiser Saquib, Abdulaziz A Al-Khedhairy, Javed Ahmad, Maqsood A Siddiqui, Javed Musarra. Rhamnolipids functionalized AgNPs-induced oxidative stress and modulation of toxicity pathway genes in cultured MCF-7 cells. Colloids and surfaces. B, Biointerfaces. vol 132. 2016-03-25. PMID:26057247. |
bax, bcl2, cyclin d1, dnaja1, e2f transcription factor 1, gpx1 and hspa4, associated with apoptosis signaling, proliferation and carcinogenesis, pro inflammatory and heat shock responses in rh-agnps treated cells. |
2016-03-25 |
2023-08-13 |
human |
| Somasundaram Arumugam, Remya Sreedhar, Rajarajan A Thandavarayan, Vijayasree V Giridharan, Vengadeshprabhu Karuppagounder, Vigneshwaran Pitchaimani, Mst Rejina Afrin, Shizuka Miyashita, Mayumi Nomoto, Meilei Harima, Hiroshi Suzuki, Takashi Nakamura, Masahiko Nakamura, Kenji Suzuki, Kenichi Watanab. Telmisartan treatment targets inflammatory cytokines to suppress the pathogenesis of acute colitis induced by dextran sulphate sodium. Cytokine. vol 74. issue 2. 2016-03-18. PMID:25873126. |
similarly the apoptosis marker proteins such as cleaved caspase 3 and 7 levels were down-regulated and anti-apoptotic protein bcl2 level was significantly upregulated by telmisartan treatment. |
2016-03-18 |
2023-08-13 |
mouse |
| Ying Zheng, Zhen Wang, Yiting Tu, Hongwei Shen, Zhijie Dai, Jian Lin, Zhiguang Zho. miR-101a and miR-30b contribute to inflammatory cytokine-mediated β-cell dysfunction. Laboratory investigation; a journal of technical methods and pathology. vol 95. issue 12. 2016-03-18. PMID:26367486. |
in addition, β-cell apoptosis mediated by mir-101a and mir-30b is associated with diminished expression level of the antiapoptotic protein bcl2. |
2016-03-18 |
2023-08-13 |
Not clear |
| Manuel D Haschka, Claudia Soratroi, Susanne Kirschnek, Georg Häcker, Richard Hilbe, Stephan Geley, Andreas Villunger, Luca L Fav. The NOXA-MCL1-BIM axis defines lifespan on extended mitotic arrest. Nature communications. vol 6. 2016-03-15. PMID:25922916. |
here we conduct a mini screen exploring systematically the contribution of individual bcl2 family proteins at single cell resolution to death on extended mitotic arrest, and demonstrate that the mitotic phosphorylation of bcl2 and bclx represent a priming event for apoptosis that is ultimately triggered by noxa-dependent mcl1 degradation, enabling bim-dependent cell death. |
2016-03-15 |
2023-08-13 |
Not clear |
| L Flanagan, A U Lindner, C de Chaumont, J Kehoe, J Fay, O Bacon, S Toomey, H J Huber, B T Hennessy, E W Kay, D A McNamara, J H M Preh. BCL2 protein signalling determines acute responses to neoadjuvant chemoradiotherapy in rectal cancer. Journal of molecular medicine (Berlin, Germany). vol 93. issue 3. 2016-03-14. PMID:25388617. |
defects in apoptotic machinery lead to therapy resistance; however, to date, no study quantitatively assessed whether b cell lymphoma 2 (bcl2)-dependent regulation of mitochondrial apoptosis, effector caspase activation downstream of mitochondria or a combination of both predicts patient responses. |
2016-03-14 |
2023-08-13 |
Not clear |