| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anne Benard, Connie M Janssen, Peter J van den Elsen, Marja C J A van Eggermond, Dave S B Hoon, Cornelis J H van de Velde, Peter J K Kuppe. Chromatin status of apoptosis genes correlates with sensitivity to chemo-, immune- and radiation therapy in colorectal cancer cell lines. Apoptosis : an international journal on programmed cell death. vol 19. issue 12. 2015-09-14. PMID:25292014. |
the chromatin status of the apoptosis genes reflected the activation status of the intrinsic (bax, bcl2, caspase-9 and p53) and extrinsic (fas) pathways. |
2015-09-14 |
2023-08-13 |
Not clear |
| Y Tatsumi, R Takano, M S Islam, T Yokochi, M Itami, Y Nakamura, A Nakagawar. BMCC1, which is an interacting partner of BCL2, attenuates AKT activity, accompanied by apoptosis. Cell death & disease. vol 6. 2015-09-11. PMID:25611382. |
bmcc1, which is an interacting partner of bcl2, attenuates akt activity, accompanied by apoptosis. |
2015-09-11 |
2023-08-13 |
human |
| Y Tatsumi, R Takano, M S Islam, T Yokochi, M Itami, Y Nakamura, A Nakagawar. BMCC1, which is an interacting partner of BCL2, attenuates AKT activity, accompanied by apoptosis. Cell death & disease. vol 6. 2015-09-11. PMID:25611382. |
bmcc1 upregulation was correlated with the activation of forkhead box-o3a (foxo3a) (a downstream inducer of apoptosis, which is suppressed by akt) and induction of bcl2 inhibitor bim, suggesting that bmcc1 negatively regulates phosphorylation pathway of akt, resulted in apoptosis. |
2015-09-11 |
2023-08-13 |
human |
| Marie Jung, Kathy A Gelato, Amaury Fernández-Montalván, Stephan Siegel, Bernard Haendle. Targeting BET bromodomains for cancer treatment. Epigenomics. vol 7. issue 3. 2015-09-11. PMID:26077433. |
this is linked to its role in modulating transcription elongation of essential genes involved in cell cycle and apoptosis such as c-myc and bcl2. |
2015-09-11 |
2023-08-13 |
Not clear |
| Shu-e Cao, Jianmin Tian, Shengyang Chen, Xiaoran Zhang, Yongqiang Zhan. Role of miR-34c in ketamine-induced neurotoxicity in neonatal mice hippocampus. Cell biology international. vol 39. issue 2. 2015-09-10. PMID:25052764. |
functional assay of silencing mir-34c demonstrated that downregulation of mir-34c activated pkc-erk pathway, upregulated anti-apoptotic protein bcl2, and ameliorated ketamine-induced apoptosis in the hippocampus. |
2015-09-10 |
2023-08-13 |
mouse |
| Karla J Hut. The role of BH3-only proteins in apoptosis within the ovary. Reproduction (Cambridge, England). vol 149. issue 2. 2015-09-02. PMID:25336346. |
bh3-only proteins are pro-apoptotic members of the bcl2 family that play pivotal roles in embryonic development, tissue homeostasis and immunity by triggering cell death through the intrinsic apoptosis pathway. |
2015-09-02 |
2023-08-13 |
Not clear |
| Clifford J Cookman, Scott M Belche. Estrogen Receptor-β Up-Regulates IGF1R Expression and Activity to Inhibit Apoptosis and Increase Growth of Medulloblastoma. Endocrinology. vol 156. issue 7. 2015-08-24. PMID:25885794. |
the absence of esr2 resulted in increased apoptosis, decreased b-cell lymphoma 2 (bcl2), and igf-1 receptor (igf1r) expression, and decreased levels of active mapks (erk1/2) and protein kinase b (akt). |
2015-08-24 |
2023-08-13 |
mouse |
| Clifford J Cookman, Scott M Belche. Estrogen Receptor-β Up-Regulates IGF1R Expression and Activity to Inhibit Apoptosis and Increase Growth of Medulloblastoma. Endocrinology. vol 156. issue 7. 2015-08-24. PMID:25885794. |
treatment of med in ptch1(+/-) trp53(-/-) mice with the antiestrogen chemotherapeutic drug faslodex significantly increased symptom-free survival, which was associated with increased apoptosis and decreased bcl2 and igf1r expression and signaling. |
2015-08-24 |
2023-08-13 |
mouse |
| Geethu Emily Thomas, Jamuna S Sreeja, K K Gireesh, Hindol Gupta, Tapas K Mann. +TIP EB1 downregulates paclitaxel‑induced proliferation inhibition and apoptosis in breast cancer cells through inhibition of paclitaxel binding on microtubules. International journal of oncology. vol 46. issue 1. 2015-08-11. PMID:25310526. |
p53 and bax were upregulated and bcl2 was downregulated in the eb1‑depleted ptx‑treated mcf‑7 cells, indicating that the apoptosis occurs via a p53‑dependent pathway. |
2015-08-11 |
2023-08-13 |
Not clear |
| M Obulesu, M Jhansi Lakshm. Apoptosis in Alzheimer's disease: an understanding of the physiology, pathology and therapeutic avenues. Neurochemical research. vol 39. issue 12. 2015-08-04. PMID:25322820. |
apoptosis, a biological process that plays an essential role in normal physiology to oust a few cells and contribute to the normal growth, when impaired or influenced by various factors such as bcl2, bax, caspases, amyloid beta, tumor necrosis factor-α, amyloid precursor protein intracellular c-terminal domain, reactive oxygen species, perturbation of enzymes leads to deleterious neurodegenerative disorders like ad. |
2015-08-04 |
2023-08-13 |
Not clear |
| Haiyan Liu, Qiang Jian, Ke Xue, Cuiling Ma, Fang Xie, Rui Wang, Wenjun Liao, Yufeng Liu, Sumin Chi, Chengxin L. The MEK/ERK signalling cascade is required for sonic hedgehog signalling pathway-mediated enhancement of proliferation and inhibition of apoptosis in normal keratinocytes. Experimental dermatology. vol 23. issue 12. 2015-07-27. PMID:25256290. |
here, we provide evidence that shh signalling induces proliferation and inhibits apoptosis in normal kcs via cyclin d1 and bcl2 in an extracellular signal-regulatedkinase (mek)/extracellular signal-regulated kinase (erk)-dependent manner. |
2015-07-27 |
2023-08-13 |
Not clear |
| Haiyan Liu, Qiang Jian, Ke Xue, Cuiling Ma, Fang Xie, Rui Wang, Wenjun Liao, Yufeng Liu, Sumin Chi, Chengxin L. The MEK/ERK signalling cascade is required for sonic hedgehog signalling pathway-mediated enhancement of proliferation and inhibition of apoptosis in normal keratinocytes. Experimental dermatology. vol 23. issue 12. 2015-07-27. PMID:25256290. |
furthermore, we observed that epidermal growth factor receptor (egfr) signalling modulates the activity of shh signalling pathway; besides, shh and egfr signalling act additively to induce the erk activation and the increases in cyclin d1 and bcl2 thereby affecting proliferation and apoptosis in kcs in vitro. |
2015-07-27 |
2023-08-13 |
Not clear |
| Soraya Scuderi, Agata Grazia D'Amico, Alessandro Castorina, Concetta Federico, Giuseppina Marrazzo, Filippo Drago, Claudio Bucolo, Velia D'Agat. Davunetide (NAP) protects the retina against early diabetic injury by reducing apoptotic death. Journal of molecular neuroscience : MN. vol 54. issue 3. 2015-07-14. PMID:24488575. |
three weeks after diabetes induction, we assessed the retinal expression and distribution of apoptosis markers, cleaved caspase-3, and bcl2, by western blot and immunofluorescent analysis. |
2015-07-14 |
2023-08-12 |
rat |
| Xuejun Yang, Deguang Sun, Yu Tian, Sunbin Ling, Liming Wan. Metformin sensitizes hepatocellular carcinoma to arsenic trioxide-induced apoptosis by downregulating Bcl2 expression. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 36. issue 4. 2015-07-09. PMID:25492486. |
metformin sensitizes hepatocellular carcinoma to arsenic trioxide-induced apoptosis by downregulating bcl2 expression. |
2015-07-09 |
2023-08-13 |
Not clear |
| Xuejun Yang, Deguang Sun, Yu Tian, Sunbin Ling, Liming Wan. Metformin sensitizes hepatocellular carcinoma to arsenic trioxide-induced apoptosis by downregulating Bcl2 expression. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 36. issue 4. 2015-07-09. PMID:25492486. |
in the present study, we used metformin and ato alone or in combination and then tested proliferation, apoptosis, and bcl2 level of hcc cells. |
2015-07-09 |
2023-08-13 |
Not clear |
| Thiyagarajan Boopalan, Arunkumar Arumugam, Jacqueline Parada, Edward Saltzstein, Rajkumar Lakshmanaswam. Receptor activator for nuclear factor-κB ligand signaling promotes progesterone-mediated estrogen-induced mammary carcinogenesis. Cancer science. vol 106. issue 1. 2015-07-08. PMID:25412610. |
hormone treatments induced rankl, receptor activator of nf-κb (rank), and nf-κb in a protein kinase b-dependent manner and inhibited apoptosis by activation of anti-apoptotic protein bcl2 in mammary tumors and mcf-7 cells. |
2015-07-08 |
2023-08-13 |
rat |
| R Majeed, A Hamid, P L Sangwan, P K Chinthakindi, S Koul, S Rayees, G Singh, D M Mondhe, M J Mintoo, S K Singh, S K Rath, A K Saxen. Inhibition of phosphotidylinositol-3 kinase pathway by a novel naphthol derivative of betulinic acid induces cell cycle arrest and apoptosis in cancer cells of different origin. Cell death & disease. vol 5. 2015-07-07. PMID:25299784. |
also, this target-specific inhibition was associated with mitochondrial apoptosis as was reflected by the increased expression of mitochondrial bax, downregulated bcl2 and decreased mitochondrial levels of cytochrome c, together with reactive oxygen species generation and decline in mitochondrial membrane potential. |
2015-07-07 |
2023-08-13 |
human |
| Tamer Said Abdelkader, Seo-Na Chang, Tae-Hyun Kim, Juha Song, Dong Su Kim, Jae-Hak Par. Exposure time to caffeine affects heartbeat and cell damage-related gene expression of zebrafish Danio rerio embryos at early developmental stages. Journal of applied toxicology : JAT. vol 33. issue 11. 2015-06-29. PMID:22886764. |
we studied the effect of caffeine on heartbeat, survival and the expression of cell damage related genes, including oxidative stress (hsp70), mitochondrial metabolism (cyclin g1) and apoptosis (bax and bcl2), at early developmental stages of zebrafish embryos. |
2015-06-29 |
2023-08-12 |
zebrafish |
| Shiva Kant, Ajay Kumar, Sukh Mahendra Sing. Bicarbonate transport inhibitor SITS modulates pH homeostasis triggering apoptosis of Dalton's lymphoma: implication of novel molecular mechanisms. Molecular and cellular biochemistry. vol 397. issue 1-2. 2015-06-29. PMID:25123669. |
bct inhibition also elevated the expression of cytochrome c, caspase-9, caspase-3, bax, reactive oxygen species, and nitric oxide along with inhibition of hsp-70 and bcl2, which regulate tumor cell survival and apoptosis. |
2015-06-29 |
2023-08-13 |
Not clear |
| Debjani Ghosh, Subrata Kumar Dey, Chabita Sah. Antagonistic effects of black tea against gamma radiation-induced oxidative damage to normal lymphocytes in comparison with cancerous K562 cells. Radiation and environmental biophysics. vol 53. issue 4. 2015-06-19. PMID:24981250. |
the changes in the mrna expression of bax, bcl2, p53 and nrf2 were also followed to evaluate regulation of radiation-induced apoptosis by bte. |
2015-06-19 |
2023-08-13 |
Not clear |