| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Obulesu, M Jhansi Lakshm. Apoptosis in Alzheimer's disease: an understanding of the physiology, pathology and therapeutic avenues. Neurochemical research. vol 39. issue 12. 2015-08-04. PMID:25322820. |
apoptosis, a biological process that plays an essential role in normal physiology to oust a few cells and contribute to the normal growth, when impaired or influenced by various factors such as bcl2, bax, caspases, amyloid beta, tumor necrosis factor-α, amyloid precursor protein intracellular c-terminal domain, reactive oxygen species, perturbation of enzymes leads to deleterious neurodegenerative disorders like ad. |
2015-08-04 |
2023-08-13 |
Not clear |
| Haiyan Liu, Qiang Jian, Ke Xue, Cuiling Ma, Fang Xie, Rui Wang, Wenjun Liao, Yufeng Liu, Sumin Chi, Chengxin L. The MEK/ERK signalling cascade is required for sonic hedgehog signalling pathway-mediated enhancement of proliferation and inhibition of apoptosis in normal keratinocytes. Experimental dermatology. vol 23. issue 12. 2015-07-27. PMID:25256290. |
here, we provide evidence that shh signalling induces proliferation and inhibits apoptosis in normal kcs via cyclin d1 and bcl2 in an extracellular signal-regulatedkinase (mek)/extracellular signal-regulated kinase (erk)-dependent manner. |
2015-07-27 |
2023-08-13 |
Not clear |
| Haiyan Liu, Qiang Jian, Ke Xue, Cuiling Ma, Fang Xie, Rui Wang, Wenjun Liao, Yufeng Liu, Sumin Chi, Chengxin L. The MEK/ERK signalling cascade is required for sonic hedgehog signalling pathway-mediated enhancement of proliferation and inhibition of apoptosis in normal keratinocytes. Experimental dermatology. vol 23. issue 12. 2015-07-27. PMID:25256290. |
furthermore, we observed that epidermal growth factor receptor (egfr) signalling modulates the activity of shh signalling pathway; besides, shh and egfr signalling act additively to induce the erk activation and the increases in cyclin d1 and bcl2 thereby affecting proliferation and apoptosis in kcs in vitro. |
2015-07-27 |
2023-08-13 |
Not clear |
| Soraya Scuderi, Agata Grazia D'Amico, Alessandro Castorina, Concetta Federico, Giuseppina Marrazzo, Filippo Drago, Claudio Bucolo, Velia D'Agat. Davunetide (NAP) protects the retina against early diabetic injury by reducing apoptotic death. Journal of molecular neuroscience : MN. vol 54. issue 3. 2015-07-14. PMID:24488575. |
three weeks after diabetes induction, we assessed the retinal expression and distribution of apoptosis markers, cleaved caspase-3, and bcl2, by western blot and immunofluorescent analysis. |
2015-07-14 |
2023-08-12 |
rat |
| Xuejun Yang, Deguang Sun, Yu Tian, Sunbin Ling, Liming Wan. Metformin sensitizes hepatocellular carcinoma to arsenic trioxide-induced apoptosis by downregulating Bcl2 expression. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 36. issue 4. 2015-07-09. PMID:25492486. |
metformin sensitizes hepatocellular carcinoma to arsenic trioxide-induced apoptosis by downregulating bcl2 expression. |
2015-07-09 |
2023-08-13 |
Not clear |
| Xuejun Yang, Deguang Sun, Yu Tian, Sunbin Ling, Liming Wan. Metformin sensitizes hepatocellular carcinoma to arsenic trioxide-induced apoptosis by downregulating Bcl2 expression. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 36. issue 4. 2015-07-09. PMID:25492486. |
in the present study, we used metformin and ato alone or in combination and then tested proliferation, apoptosis, and bcl2 level of hcc cells. |
2015-07-09 |
2023-08-13 |
Not clear |
| Thiyagarajan Boopalan, Arunkumar Arumugam, Jacqueline Parada, Edward Saltzstein, Rajkumar Lakshmanaswam. Receptor activator for nuclear factor-κB ligand signaling promotes progesterone-mediated estrogen-induced mammary carcinogenesis. Cancer science. vol 106. issue 1. 2015-07-08. PMID:25412610. |
hormone treatments induced rankl, receptor activator of nf-κb (rank), and nf-κb in a protein kinase b-dependent manner and inhibited apoptosis by activation of anti-apoptotic protein bcl2 in mammary tumors and mcf-7 cells. |
2015-07-08 |
2023-08-13 |
rat |
| R Majeed, A Hamid, P L Sangwan, P K Chinthakindi, S Koul, S Rayees, G Singh, D M Mondhe, M J Mintoo, S K Singh, S K Rath, A K Saxen. Inhibition of phosphotidylinositol-3 kinase pathway by a novel naphthol derivative of betulinic acid induces cell cycle arrest and apoptosis in cancer cells of different origin. Cell death & disease. vol 5. 2015-07-07. PMID:25299784. |
also, this target-specific inhibition was associated with mitochondrial apoptosis as was reflected by the increased expression of mitochondrial bax, downregulated bcl2 and decreased mitochondrial levels of cytochrome c, together with reactive oxygen species generation and decline in mitochondrial membrane potential. |
2015-07-07 |
2023-08-13 |
human |
| Tamer Said Abdelkader, Seo-Na Chang, Tae-Hyun Kim, Juha Song, Dong Su Kim, Jae-Hak Par. Exposure time to caffeine affects heartbeat and cell damage-related gene expression of zebrafish Danio rerio embryos at early developmental stages. Journal of applied toxicology : JAT. vol 33. issue 11. 2015-06-29. PMID:22886764. |
we studied the effect of caffeine on heartbeat, survival and the expression of cell damage related genes, including oxidative stress (hsp70), mitochondrial metabolism (cyclin g1) and apoptosis (bax and bcl2), at early developmental stages of zebrafish embryos. |
2015-06-29 |
2023-08-12 |
zebrafish |
| Shiva Kant, Ajay Kumar, Sukh Mahendra Sing. Bicarbonate transport inhibitor SITS modulates pH homeostasis triggering apoptosis of Dalton's lymphoma: implication of novel molecular mechanisms. Molecular and cellular biochemistry. vol 397. issue 1-2. 2015-06-29. PMID:25123669. |
bct inhibition also elevated the expression of cytochrome c, caspase-9, caspase-3, bax, reactive oxygen species, and nitric oxide along with inhibition of hsp-70 and bcl2, which regulate tumor cell survival and apoptosis. |
2015-06-29 |
2023-08-13 |
Not clear |
| Debjani Ghosh, Subrata Kumar Dey, Chabita Sah. Antagonistic effects of black tea against gamma radiation-induced oxidative damage to normal lymphocytes in comparison with cancerous K562 cells. Radiation and environmental biophysics. vol 53. issue 4. 2015-06-19. PMID:24981250. |
the changes in the mrna expression of bax, bcl2, p53 and nrf2 were also followed to evaluate regulation of radiation-induced apoptosis by bte. |
2015-06-19 |
2023-08-13 |
Not clear |
| Priyanka Bhatnagar, Soma Patnaik, Amit K Srivastava, Mohan K R Mudiam, Yogeshwer Shukla, Amulya K Panda, Aditya B Pant, Pradeep Kumar, Kailash C Gupt. Anti-cancer activity of bromelain nanoparticles by oral administration. Journal of biomedical nanotechnology. vol 10. issue 12. 2015-06-18. PMID:26000370. |
altered expression of marker proteins associated with apoptosis and cell death (p53, p21, bcl2, bax) also confirmed the enhanced anti-carcinogenic potential of formulated nps. |
2015-06-18 |
2023-08-13 |
mouse |
| J Long, Y X Su, H C Den. Lipoapoptosis pathways in pancreatic β-cells and the anti-apoptosis mechanisms of adiponectin. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 46. issue 10. 2015-06-16. PMID:25028793. |
adiponectin prevents pancreatic β-cells from apoptosis by inhibition of intrinsic apoptosis pathway via regulation of the bcl2 family. |
2015-06-16 |
2023-08-13 |
Not clear |
| Mohammad Hassan Naseri, Majid Mahdavi, Jamshid Davoodi, Saeed Hesami Tackallou, Mahdi Goudarzvand, Shima Hallaj Neishabour. Up regulation of Bax and down regulation of Bcl2 during 3-NC mediated apoptosis in human cancer cells. Cancer cell international. vol 15. 2015-06-15. PMID:26074734. |
up regulation of bax and down regulation of bcl2 during 3-nc mediated apoptosis in human cancer cells. |
2015-06-15 |
2023-08-13 |
human |
| Tanmoy Bhowmik, Partha Pratim Saha, Anjan Kumar DasGupta, Antony Gome. Influence of gold nanoparticle tagged snake venom protein toxin NKCT1 on Ehrlich ascites carcinoma (EAC) and EAC induced solid tumor bearing male albino mice. Current drug delivery. vol 11. issue 5. 2015-06-08. PMID:24827982. |
with upregulation of bax, down regulation of bcl2 and increased expression of caspase 3/9, it was confirmed that gnp-nkct1 induced caspase dependent apoptosis pathway in eac cell. |
2015-06-08 |
2023-08-13 |
mouse |
| Jinhee Kim, G K Jayaprakasha, Bhimanagouda S Pati. Obacunone exhibits anti-proliferative and anti-aromatase activity in vitro by inhibiting the p38 MAPK signaling pathway in MCF-7 human breast adenocarcinoma cells. Biochimie. vol 105. 2015-05-29. PMID:24927687. |
treatment with obacunone increased apoptosis by up-regulating expression of the pro-apoptotic protein bax and down-regulating the anti-apoptotic protein bcl2, as well as inducing g1 cell cycle arrest. |
2015-05-29 |
2023-08-13 |
human |
| Jung-Jung Changchien, Ying-Jung Chen, Chia-Hui Huang, Tian-Lu Cheng, Shinne-Ren Lin, Long-Sen Chan. Quinacrine induces apoptosis in human leukemia K562 cells via p38 MAPK-elicited BCL2 down-regulation and suppression of ERK/c-Jun-mediated BCL2L1 expression. Toxicology and applied pharmacology. vol 284. issue 1. 2015-05-20. PMID:25684043. |
quinacrine induces apoptosis in human leukemia k562 cells via p38 mapk-elicited bcl2 down-regulation and suppression of erk/c-jun-mediated bcl2l1 expression. |
2015-05-20 |
2023-08-13 |
human |
| Jung-Jung Changchien, Ying-Jung Chen, Chia-Hui Huang, Tian-Lu Cheng, Shinne-Ren Lin, Long-Sen Chan. Quinacrine induces apoptosis in human leukemia K562 cells via p38 MAPK-elicited BCL2 down-regulation and suppression of ERK/c-Jun-mediated BCL2L1 expression. Toxicology and applied pharmacology. vol 284. issue 1. 2015-05-20. PMID:25684043. |
quinacrine induced k562 cell apoptosis accompanied with ros generation, mitochondrial depolarization, and down-regulation of bcl2l1 and bcl2. |
2015-05-20 |
2023-08-13 |
human |
| Jung-Jung Changchien, Ying-Jung Chen, Chia-Hui Huang, Tian-Lu Cheng, Shinne-Ren Lin, Long-Sen Chan. Quinacrine induces apoptosis in human leukemia K562 cells via p38 MAPK-elicited BCL2 down-regulation and suppression of ERK/c-Jun-mediated BCL2L1 expression. Toxicology and applied pharmacology. vol 284. issue 1. 2015-05-20. PMID:25684043. |
taken together, our data indicate that quinacrine-induced k562 cell apoptosis is mediated through mitochondrial alterations triggered by p38 mapk-mediated bcl2 down-regulation and suppression of erk/c-jun-mediated bcl2l1 expression. |
2015-05-20 |
2023-08-13 |
human |
| Abir Chaabane, Issam M'Sakni, Manel Yahia, Fethi Bougrine, Besma Laabidi, Ramzi Khiari, Samir Ghozzi, Naoufel Berraies, Ammar Bouzian. [Prognostic value of markers of aggressiveness of urinary bladder tumours evaluated by immunohistochemistry]. La Tunisie medicale. vol 92. issue 3. 2015-05-18. PMID:24955967. |
aims: study the expression of the following immunohistochemical markers in tumours of the bladder: proliferating cell nuclear antigen (pcna), ki67 antigen (mib1), the c-erbb2 proto- antigene, the tumor suppressor gene p53, the receptor for epidermal growth factor (egf-r), the apoptosis suppressor gene bcl2, the carcinoembryonic antigen (cea) and epithelial membrane antigen (ema). |
2015-05-18 |
2023-08-13 |
Not clear |