| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| JinYan Chen, MengRu Sun, XingHua Wang, Jing Lu, Yan Wei, Yan Tan, Ying Liu, Jürgen Götz, RongQiao He, Qian Hu. The herbal compound geniposide rescues formaldehyde-induced apoptosis in N2a neuroblastoma cells. Science China. Life sciences. vol 57. issue 4. 2014-12-16. PMID:24658849. |
fa-exposed murine n2a neuroblastoma cells were incubated with tljn, its main ingredient gp, as well as pns, to measure cell viability and morphology, the rate of apoptosis and expression of genes encoding akt, foxo3, bcl2 and p53. |
2014-12-16 |
2023-08-12 |
mouse |
| Cristiane Oliveira, Gustavo Jacob Lourenço, José Augusto Rinck-Junior, Maria Letícia Cintra, Aparecida Machado Moraes, Carmen Silvia Passos Lim. Association between genetic polymorphisms in apoptosis-related genes and risk of cutaneous melanoma in women and men. Journal of dermatological science. vol 74. issue 2. 2014-12-09. PMID:24461648. |
the p53 arg72pro, mdm2 c.+309t>g, bax c.-248g>a, and bcl2 c.-717c>a polymorphisms have variable roles in the apoptosis pathways. |
2014-12-09 |
2023-08-12 |
Not clear |
| Magdalena Nowakowska, Elżbieta Płuciennik, Wioletta I Wujcicka, Anna Sitkiewicz, Bernarda Kazanowska, Elżbieta Zielińska, Andrzej K Bednare. The correlation analysis of WWOX expression and cancer related genes in neuroblastoma- a real time RT-PCR study. Acta biochimica Polonica. vol 61. issue 1. 2014-11-25. PMID:24455756. |
we performed real-time rt-pcr to analyse levels of wwox expression in 22 neuroblastic tumour samples in correlation with genes involved in cell cycle regulation (ccne1, ccnd1), proliferation (mki67), apoptosis (bcl2, birc5, bax) and signal transduction (egfr, erbb4). |
2014-11-25 |
2023-08-12 |
Not clear |
| Shuvasree Sarkar, Sandip Mukherjee, Ansuman Chattopadhyay, Shelley Bhattachary. Low dose of arsenic trioxide triggers oxidative stress in zebrafish brain: expression of antioxidant genes. Ecotoxicology and environmental safety. vol 107. 2014-11-21. PMID:24905690. |
the oxidative stress induced by arsenic also cause reduced mrna expression of b-cell lymphoma 2 (bcl2) present in the inner mitochondrial membrane and thereby indicating onset of apoptosis in treated fish. |
2014-11-21 |
2023-08-13 |
cat |
| Pankaj Chaudhary, Jamboor K Vishwanath. c-Jun NH2-terminal kinase-induced proteasomal degradation of c-FLIPL/S and Bcl2 sensitize prostate cancer cells to Fas- and mitochondria-mediated apoptosis by tetrandrine. Biochemical pharmacology. vol 91. issue 4. 2014-11-21. PMID:25181458. |
c-jun nh2-terminal kinase-induced proteasomal degradation of c-flipl/s and bcl2 sensitize prostate cancer cells to fas- and mitochondria-mediated apoptosis by tetrandrine. |
2014-11-21 |
2023-08-13 |
Not clear |
| Pankaj Chaudhary, Jamboor K Vishwanath. c-Jun NH2-terminal kinase-induced proteasomal degradation of c-FLIPL/S and Bcl2 sensitize prostate cancer cells to Fas- and mitochondria-mediated apoptosis by tetrandrine. Biochemical pharmacology. vol 91. issue 4. 2014-11-21. PMID:25181458. |
jnk1/2-mediated proteasomal degradation of c-flipl/s and bcl2 proteins are key events in the sensitization of prostate cancer cells to fas- and mitochondria-mediated apoptosis by tetrandrine. |
2014-11-21 |
2023-08-13 |
Not clear |
| Yonju Ha, Arul K Shanmugam, Shanu Markand, Eric Zorrilla, Vadivel Ganapathy, Sylvia B Smit. Sigma receptor 1 modulates ER stress and Bcl2 in murine retina. Cell and tissue research. vol 356. issue 1. 2014-11-18. PMID:24469320. |
we therefore used σr1(-/-) mice to investigate the expression of er stress genes (bip/grp78, atf6, atf4, ire1α) and proteins involved in apoptosis (bcl2, bax) and to examine the retinal transcriptome at young ages. |
2014-11-18 |
2023-08-12 |
mouse |
| Jen-Jyh Lin, Chien-Chih Yu, Kung-Wen Lu, Shu-Jen Chang, Fu-Shun Yu, Ching-Lung Liao, Jaung-Geng Lin, Jing-Gung Chun. α-Phellandrene alters expression of genes associated with DNA damage, cell cycle, and apoptosis in murine leukemia WEHI-3 cells. Anticancer research. vol 34. issue 8. 2014-11-11. PMID:25075043. |
dna damage-associated genes such as dna damage-inducer transcript 4 and dna fragmentation factor were up-regulated by 4-fold and over 2-fold, respectively; cell-cycle check point genes such as cyclin g2 and cyclin-dependent kinases inhibitor 2d and ia (p21) were up-regulated by over 3-fold and over 2-fold, respectively; apoptosis-associated genes such as bcl2/adenovirus eib interacting protein 3, xiap-associated factor 1, bcl2 modifying factor, caspase-8 and fadd-like apoptosis regulator were over 2-fold up-regulated. |
2014-11-11 |
2023-08-13 |
mouse |
| Eman El Ete. NQDI 1, an inhibitor of ASK1 attenuates acute ischemic renal injury by modulating oxidative stress and cell death. Cardiovascular & hematological agents in medicinal chemistry. vol 11. issue 3. 2014-11-04. PMID:23952292. |
apoptosis of renal tissues, as detected by tunel staining, was also reduced together with p53 protein expression, and renal levels of mda and sod with nqdi 1 administration and bcl2 was up regulated. |
2014-11-04 |
2023-08-12 |
rat |
| Jianxin Shi, Qingqi Han, Heng Zhao, Chenxi Zhong, Feng Ya. Downregulation of MED23 promoted the tumorigenecity of esophageal squamous cell carcinoma. Molecular carcinogenesis. vol 53. issue 10. 2014-11-03. PMID:23625751. |
mechanistically, knockdown the expression of med23 inhibited cell apoptosis by downregulation of bax, activated caspase 3, activated caspase 9 and upregulation of cyclind1 and bcl2. |
2014-11-03 |
2023-08-12 |
Not clear |
| Shiva Kant, Ajay Kumar, Sukh Mahendra Sing. Myelopoietic efficacy of orlistat in murine hosts bearing T cell lymphoma: implication in macrophage differentiation and activation. PloS one. vol 8. issue 12. 2014-10-12. PMID:24349275. |
the expression of apoptosis regulatory caspase-3, bax and bcl2 was modulated in the bmc of orlistat-administered tumor-bearing mice. |
2014-10-12 |
2023-08-12 |
mouse |
| Xin Jiang, Yang Bai, Zhiguo Zhang, Ying Xin, Lu Ca. Protection by sulforaphane from type 1 diabetes-induced testicular apoptosis is associated with the up-regulation of Nrf2 expression and function. Toxicology and applied pharmacology. vol 279. issue 2. 2014-10-12. PMID:24967692. |
diabetes significantly increased testicular apoptosis that was associated with endoplasmic reticulum stress and mitochondrial cell death pathways, shown by the increased expression of c/ebp homologous protein (chop), cleaved caspase-12, bax to bcl2 expression ratio, and cleaved caspase-3. |
2014-10-12 |
2023-08-13 |
mouse |
| Ryan S Soderquist, Alexey V Danilov, Alan Eastma. Gossypol increases expression of the pro-apoptotic BH3-only protein NOXA through a novel mechanism involving phospholipase A2, cytoplasmic calcium, and endoplasmic reticulum stress. The Journal of biological chemistry. vol 289. issue 23. 2014-10-07. PMID:24778183. |
we demonstrated previously that gossypol failed to directly inhibit bcl2 in cells or induce apoptosis in chronic lymphocytic leukemia (cll) cells or platelets, which require bcl2 or bclxl, respectively, for survival. |
2014-10-07 |
2023-08-13 |
Not clear |
| Letícia da Conceição Braga, Luciana Maria Silva, Josiane Barbosa Piedade, Paulo Traiman, Agnaldo Lopes da Silva Filh. Epigenetic and expression analysis of TRAIL-R2 and BCL2: on the TRAIL to knowledge of apoptosis in ovarian tumors. Archives of gynecology and obstetrics. vol 289. issue 5. 2014-10-06. PMID:24190693. |
epigenetic and expression analysis of trail-r2 and bcl2: on the trail to knowledge of apoptosis in ovarian tumors. |
2014-10-06 |
2023-08-12 |
Not clear |
| Mary Ann Anderson, David Huang, Andrew Robert. Targeting BCL2 for the treatment of lymphoid malignancies. Seminars in hematology. vol 51. issue 3. 2014-09-30. PMID:25048785. |
in hematologic malignancies, this impairment of apoptosis is often caused by overexpression of the pro-survival protein bcl2. |
2014-09-30 |
2023-08-13 |
Not clear |
| K R Sumalatha, G Abiramasundari, G K Chetan, T Divya, G Sudhandiran, M Sreepriy. XIAP inhibitor and antiestrogen embelin abrogates metastasis and augments apoptosis in estrogen receptor positive human breast adenocarcinoma cell line MCF-7. Molecular biology reports. vol 41. issue 2. 2014-09-29. PMID:24390234. |
results revealed that, embelin at a concentration of 65 μg/ml attenuated proliferation, inhibited metastatic migration, modulated the expression of bcl2, caspases and induced apoptosis in mcf-7 cells which was found to be p53 mediated. |
2014-09-29 |
2023-08-12 |
human |
| Leonid Schneide. Survival of neural stem cells undergoing DNA damage-induced astrocytic differentiation in self-renewal-promoting conditions in vitro. PloS one. vol 9. issue 1. 2014-09-29. PMID:24475256. |
surprisingly, under self-renewing culture conditions, some of these senescent cells undergo p53-independent apoptosis, which can be suppressed by caspase inhibition and bcl2 overexpression. |
2014-09-29 |
2023-08-12 |
Not clear |
| Olga S Sizova, Vishal M Shinde, Austin R Lenox, Marina S Gorbatyu. Modulation of cellular signaling pathways in P23H rhodopsin photoreceptors. Cellular signalling. vol 26. issue 4. 2014-09-24. PMID:24378535. |
we also looked for changes in the expression of bcl2 family proteins, autophagy proteins and the mtor/akt pathways, as well as for the induction of mitochondria-associated apoptosis in the p23h rho retina. |
2014-09-24 |
2023-08-12 |
Not clear |
| Wenchang Guo, Ruiwu Liu, Gaurav Bhardwaj, Ai-Hong Ma, Chun Changou, Joy C Yang, Yuanpei Li, Caihong Feng, Yan Luo, Anisha Mazloom, Eduardo Sanchez, Yan Wang, Wenzhe Huang, Randen Patterson, Christopher P Evans, Kit S Lam, Hsing-Jien Kun. CTA095, a novel Etk and Src dual inhibitor, induces apoptosis in prostate cancer cells and overcomes resistance to Src inhibitors. PloS one. vol 8. issue 8. 2014-09-23. PMID:23967135. |
it induces apoptosis in src inhibitor resistant prostate cancer cells, likely through a mechanism of down regulation of myc and bcl2. |
2014-09-23 |
2023-08-12 |
human |
| Song Zhang, Yang Yang, Zhenxing Liang, Weixun Duan, Jian Yang, Juanjuan Yan, Ning Wang, Wenqiang Feng, Meiling Ding, Yongzhan Nie, Zhenxiao Ji. Silybin-mediated inhibition of Notch signaling exerts antitumor activity in human hepatocellular carcinoma cells. PloS one. vol 8. issue 12. 2014-09-16. PMID:24386256. |
furthermore, sil treatment decreased the expression of the notch1 intracellular domain (nicd), rbp-jκ, and hes1 proteins, upregulated the apoptosis pathway-related protein bax, and downregulated bcl2, survivin, and cyclin d1. |
2014-09-16 |
2023-08-12 |
human |