| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Samak Sutjarit, Shota M M Nakayama, Yoshinori Ikenaka, Mayumi Ishizuka, Wijit Banlunara, Worawut Rerkamnuaychoke, Susumu Kumagai, Amnart Poapolathe. Apoptosis and gene expression in the developing mouse brain of fusarenon-X-treated pregnant mice. Toxicology letters. vol 229. issue 1. 2014-09-08. PMID:24983900. |
moreover, the genetic regulatory mechanisms of fx-induced apoptosis are regulated by bax, bcl2, trp53 and casp9 or can be defined via an intrinsic apoptotic pathway. |
2014-09-08 |
2023-08-13 |
mouse |
| Vicente Fresquet, Melissa Rieger, Carlo Carolis, Maria J García-Barchino, Jose A Martinez-Climen. Acquired mutations in BCL2 family proteins conferring resistance to the BH3 mimetic ABT-199 in lymphoma. Blood. vol 123. issue 26. 2014-09-04. PMID:24786774. |
our study reveals the acquisition of mutations in bcl2 family proteins as a novel mechanism of apoptosis resistance in cancer. |
2014-09-04 |
2023-08-13 |
mouse |
| Ryan Soderquist, Alexandre A Pletnev, Alexey V Danilov, Alan Eastma. The putative BH3 mimetic S1 sensitizes leukemia to ABT-737 by increasing reactive oxygen species, inducing endoplasmic reticulum stress, and upregulating the BH3-only protein NOXA. Apoptosis : an international journal on programmed cell death. vol 19. issue 1. 2014-09-02. PMID:24072590. |
however, we previously demonstrated that it failed to inhibit bcl2 or induce apoptosis in chronic lymphocytic leukemia (cll) cells, which are dependent on bcl2 for survival. |
2014-09-02 |
2023-08-12 |
human |
| Rajan Singh, Nuraly K Avliyakulov, Melissa Braga, Michael J Haykinson, Luis Martinez, Vikash Singh, Meher Parveen, Gautam Chaudhuri, Shehla Pervi. Proteomic identification of mitochondrial targets of arginase in human breast cancer. PloS one. vol 8. issue 11. 2014-08-26. PMID:24223914. |
the over-expression of bcl2 in mda-mb-468 cells abolished noha-induced apoptosis, suggesting that the mitochondria may be the main site of noha's action. |
2014-08-26 |
2023-08-12 |
human |
| P I F Inserra, N P Leopardo, M A Willis, A L Freysselinard, A D Vitull. Quantification of healthy and atretic germ cells and follicles in the developing and post-natal ovary of the South American plains vizcacha, Lagostomus maximus: evidence of continuous rise of the germinal reserve. Reproduction (Cambridge, England). vol 147. issue 2. 2014-08-26. PMID:24231369. |
germ cell demise occurs mainly through apoptosis by means of a biased expression in favour of pro-apoptotic members of the bcl2 gene family. |
2014-08-26 |
2023-08-12 |
Not clear |
| P I F Inserra, N P Leopardo, M A Willis, A L Freysselinard, A D Vitull. Quantification of healthy and atretic germ cells and follicles in the developing and post-natal ovary of the South American plains vizcacha, Lagostomus maximus: evidence of continuous rise of the germinal reserve. Reproduction (Cambridge, England). vol 147. issue 2. 2014-08-26. PMID:24231369. |
by contrast, the south american plains vizcacha, lagostomus maximus, exhibits sustained expression of the anti-apoptotic bcl2 gene throughout gestation and a low incidence of germ cell apoptosis. |
2014-08-26 |
2023-08-12 |
Not clear |
| Syam Mohan, Siddig Ibrahim Abdelwahab, Behnam Kamalidehghan, Suvitha Syam, Koh Sue May, Nabil Saad Mohammed Harmal, Noor Shafifiyaz, A Hamid A Hadi, Najihah Mohd Hashim, Mawardi Rahmani, Manal Mohamed Elhassan Taha, Shiau-Chuen Cheah, Asdren Zajm. Involvement of NF-κB and Bcl2/Bax signaling pathways in the apoptosis of MCF7 cells induced by a xanthone compound Pyranocycloartobiloxanthone A. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 19. issue 11. 2014-08-25. PMID:22739412. |
treatment of mcf7 cells with pa induced apoptosis with cell death-transducing signals, that regulate the mmp by down-regulation of bcl2 and up-regulation of bax, triggering the cytochrome c release from mitochondria to cytosol. |
2014-08-25 |
2023-08-12 |
human |
| Srividya Vasu, Neville H McClenaghan, Jane T McCluskey, Peter R Flat. Cellular responses of novel human pancreatic β-cell line, 1.1B4 to hyperglycemia. Islets. vol 5. issue 4. 2014-08-20. PMID:23985558. |
hyperglycemia-induced apoptosis was evident from increased activity of caspase 3/7 and decreased bcl2 protein. |
2014-08-20 |
2023-08-12 |
human |
| Krishnendu Sinha, Pabitra Bikash Pal, Parames C Si. Cadmium (Cd(2+)) exposure differentially elicits both cell proliferation and cell death related responses in SK-RC-45. Toxicology in vitro : an international journal published in association with BIBRA. vol 28. issue 2. 2014-08-20. PMID:24291162. |
also phosphatidylserine externalization, augmentation in the level of caspase-3, parp, bad, apaf1 and cleaved caspase-9 along with decreased expression of bcl2 and release of cytochrome c confirmed that, cd(2+) dose dependently induces solely intrinsic pathway of apoptosis in sk-rc-45, independent of jnk. |
2014-08-20 |
2023-08-12 |
human |
| A Lin, J Yao, L Zhuang, D Wang, J Han, E W-F Lam, B Ga. The FoxO-BNIP3 axis exerts a unique regulation of mTORC1 and cell survival under energy stress. Oncogene. vol 33. issue 24. 2014-08-07. PMID:23851496. |
integrated transcriptomic and functional analyses identified bcl2/adenovirus e1b 19 kda protein-interacting protein 3 (bnip3)-a negative regulator of both rheb and bcl2 prosurvival family members-as a key downstream target of foxos to inhibit mtorc1 function and promote apoptosis in response to energy stress. |
2014-08-07 |
2023-08-12 |
human |
| Elias Georges, Jing Lian, Remi Laberg. A tamoxifen derivative, N,N-diethyl-2-[4-(phenylmethyl) phenoxy] ethanamine, selectively targets P-glycoprotein-positive multidrug resistant Chinese hamster cells. Biochemical pharmacology. vol 90. issue 2. 2014-08-01. PMID:24821111. |
moreover, in mdr cells, dppe-induced apoptosis was significantly reduced with bcl2 overexpression and in the presence of p-gp atpase inhibitor, psc833. |
2014-08-01 |
2023-08-13 |
Not clear |
| Ting Gui, Yueming Wang, Lixing Zhang, Wenjing Wang, Hao Zhu, Wenlong Din. Krüppel-like factor 6 rendered rat Schwann cell more sensitive to apoptosis via upregulating FAS expression. PloS one. vol 8. issue 12. 2014-07-31. PMID:24324791. |
although klf6 overexpression exacerbated cisplatin- and tnfα-induced apoptosis, expression levels of the apoptosis regulators bcl2 and bax were not significantly affected in either klf6-overexpressing or klf6-depleted rsc96 cells. |
2014-07-31 |
2023-08-12 |
rat |
| Rocio Sanchez, Janick St-Cyr, Marie-Eve Lalonde, Jasmine Healy, Chantal Richer, Vincent Gagné, Caroline Laverdière, Lewis B Silverman, Stephen E Sallan, Donna Neuberg, Jeffery L Kutok, Ekaterini A Kritikou, Maja Krajinovic, Daniel Sinnet. Impact of promoter polymorphisms in key regulators of the intrinsic apoptosis pathway on the outcome of childhood acute lymphoblastic leukemia. Haematologica. vol 99. issue 2. 2014-07-24. PMID:24038028. |
using gene reporter assays, we show that promoter variations in 11 intrinsic apoptosis genes, including adprt, apaf1, bcl2, bad, bid, mcl1, birc4, bcl2l1, endog, ywhab, and ywhaq, influence promoter activity in an allele-specific manner. |
2014-07-24 |
2023-08-12 |
Not clear |
| Yeong-In Yang, Ji-Hye Ahn, Kyung-Tae Lee, Ie-Ming Shih, Jung-Hye Cho. RSF1 is a positive regulator of NF-κB-induced gene expression required for ovarian cancer chemoresistance. Cancer research. vol 74. issue 8. 2014-07-24. PMID:24566868. |
in addition, rsf1-overexpressing paclitaxel-resistant ovarian cancer cell lines were found to express elevated levels of genes regulated by nf-κb, including some involved with the evasion of apoptosis (cflar, xiap, bcl2, and bcl2l1) and inflammation (ptgs2). |
2014-07-24 |
2023-08-12 |
mouse |
| Patricia Gassó, Sergi Mas, Oriol Molina, Amalia Lafuente, Miquel Bernardo, Eduard Parellad. Increased susceptibility to apoptosis in cultured fibroblasts from antipsychotic-naïve first-episode schizophrenia patients. Journal of psychiatric research. vol 48. issue 1. 2014-07-18. PMID:24128664. |
cell growth, cell viability and various apoptotic hallmarks (caspase-3 activity, translocation of phosphatidylserine, chromatin condensation and gene expression of akt1, bax, bcl2, casp3, gsk3b and p53) were measured in fibroblast cultures obtained from skin biopsies of patients (n = 11) and healthy controls (n = 8), both in basal conditions and after inducing apoptosis with staurosporine. |
2014-07-18 |
2023-08-12 |
Not clear |
| Indrajit Chowdhury, Winston E Thompson, Crystal Welch, Kelwyn Thomas, Roland Matthew. Prohibitin (PHB) inhibits apoptosis in rat granulosa cells (GCs) through the extracellular signal-regulated kinase 1/2 (ERK1/2) and the Bcl family of proteins. Apoptosis : an international journal on programmed cell death. vol 18. issue 12. 2014-07-15. PMID:24096434. |
these studies indicated that over-expression of phb in undifferentiated gcs inhibit apoptosis which concomitantly results in an increased level of the anti-apoptotic proteins bcl2 and bclxl, reduced release of cytochrome c from mitochondria and inhibition of caspase-3 activity. |
2014-07-15 |
2023-08-12 |
rat |
| Lydia Scarfò, Paolo Ghi. Reprogramming cell death: BCL2 family inhibition in hematological malignancies. Immunology letters. vol 155. issue 1-2. 2014-07-14. PMID:24095849. |
the bcl2 family members play a central role in regulating programmed cell death (apoptosis) and arbitrating the cellular fate through an accurate balance between pro-apoptotic (bax, bak, and bh3-only proteins) and pro-survival (bcl2 and its closest homologues, bclxl, bclw and mcl-1) factors. |
2014-07-14 |
2023-08-12 |
human |
| Lydia Scarfò, Paolo Ghi. Reprogramming cell death: BCL2 family inhibition in hematological malignancies. Immunology letters. vol 155. issue 1-2. 2014-07-14. PMID:24095849. |
for all these reasons, the opportunity to induce apoptosis by targeting bcl2 proteins is considered a potentially promising therapeutic approach in hematological malignancies. |
2014-07-14 |
2023-08-12 |
human |
| Walid Medhioub, Simon Ramondenc, Audrey Sophie Vanhove, Agnes Vergnes, Estelle Masseret, Veronique Savar, Zouher Amzil, Mohamed Laabir, Jean Luc Rollan. Exposure to the neurotoxic dinoflagellate, Alexandrium catenella, induces apoptosis of the hemocytes of the oyster, Crassostrea gigas. Marine drugs. vol 11. issue 12. 2014-07-10. PMID:24317471. |
moreover, the clear time-dependent upregulation of five (bcl2, bi-1, iap1, iap7b and hsp70) inhibitors of apoptosis-related genes associated with the return to the initial number of hemocytes in apoptosis at 48 h of exposure suggests the involvement of strong regulatory mechanisms of apoptosis occurring in the hemocytes of the pacific oyster. |
2014-07-10 |
2023-08-12 |
Not clear |
| Rekha Meena, Man Mohan Misro, Debidas Ghos. Complete sperm suppression in rats with dienogest plus testosterone undecanoate is facilitated through apoptosis in testicular cells. Reproductive sciences (Thousand Oaks, Calif.). vol 20. issue 7. 2014-07-02. PMID:23202726. |
rise in the activities of caspase 8 and 9 was associated with overexpression of upstream marker proteins from extrinsic (fas [fatty acid synthase], fasl [fatty acid synthase ligand], and caspase 8) and intrinsic (bax [bcl2-associated-x protein], bcl2 [b-cell lymphoma 2], and caspase 9) pathways of apoptosis. |
2014-07-02 |
2023-08-12 |
rat |