| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hyunkeun Song, Il-Yong Han, Yeonye Kim, Young Hwan Kim, Il-Whan Choi, Su-Kil Seo, So Young Jung, SaeGwang Park, Mi Seon Kan. The NADPH oxidase inhibitor DPI can abolish hypoxia-induced apoptosis of human kidney proximal tubular epithelial cells through Bcl2 up-regulation via ERK activation without ROS reduction. Life sciences. vol 126. 2015-05-11. PMID:25744050. |
the nadph oxidase inhibitor dpi can abolish hypoxia-induced apoptosis of human kidney proximal tubular epithelial cells through bcl2 up-regulation via erk activation without ros reduction. |
2015-05-11 |
2023-08-13 |
human |
| Dongsun Park, Kyungha Shin, Ehn-Kyoung Choi, Youngjin Choi, Ja-Young Jang, Jihyun Kim, Heon-Sang Jeong, Wooryoung Lee, Yoon-Bok Lee, Seung Up Kim, Seong Soo Joo, Yun-Bae Ki. Protective effects of N-acetyl-L-cysteine in human oligodendrocyte progenitor cells and restoration of motor function in neonatal rats with hypoxic-ischemic encephalopathy. Evidence-based complementary and alternative medicine : eCAM. vol 2015. 2015-04-28. PMID:25918547. |
nac decreased kcn cytotoxicity in f3.olig2 cells and especially suppressed apoptosis by regulating bcl2 and p-erk. |
2015-04-28 |
2023-08-13 |
human |
| Achinto Saha, Jorge Blando, Eric Silver, Linda Beltran, Jonathan Sessler, John DiGiovann. 6-Shogaol from dried ginger inhibits growth of prostate cancer cells both in vitro and in vivo through inhibition of STAT3 and NF-κB signaling. Cancer prevention research (Philadelphia, Pa.). vol 7. issue 6. 2015-04-16. PMID:24691500. |
in addition, 6-sho decreased the level of several stat3 and nf-κb-regulated target genes at the protein level, including cyclin d1, survivin, and cmyc and modulated mrna levels of chemokine, cytokine, cell cycle, and apoptosis regulatory genes (il-7, ccl5, bax, bcl2, p21, and p27). |
2015-04-16 |
2023-08-13 |
mouse |
| Devora Champa, Marika A Russo, Xiao-Hui Liao, Samuel Refetoff, Ronald A Ghossein, Antonio Di Cristofan. Obatoclax overcomes resistance to cell death in aggressive thyroid carcinomas by countering Bcl2a1 and Mcl1 overexpression. Endocrine-related cancer. vol 21. issue 5. 2015-04-13. PMID:25012986. |
using primary carcinomas as well as carcinoma-derived cell lines, we also demonstrate that these tumors are intrinsically resistant to apoptosis due to high levels of expression of the bcl2 family members, bcl2a1 (bcl2a1a) and mcl1, and can be effectively targeted by obatoclax, a small-molecule pan-inhibitor of the bcl2 family. |
2015-04-13 |
2023-08-13 |
mouse |
| Xiaoxian Zhao, Juraj Bodo, Danyu Sun, Lisa Durkin, Jeffrey Lin, Mitchell R Smith, Eric D Hs. Combination of ibrutinib with ABT-199: synergistic effects on proliferation inhibition and apoptosis in mantle cell lymphoma cells through perturbation of BTK, AKT and BCL2 pathways. British journal of haematology. vol 168. issue 5. 2015-04-10. PMID:25284608. |
combination of ibrutinib with abt-199: synergistic effects on proliferation inhibition and apoptosis in mantle cell lymphoma cells through perturbation of btk, akt and bcl2 pathways. |
2015-04-10 |
2023-08-13 |
Not clear |
| Y Lei, B R Henderson, C Emmanuel, P R Harnett, A deFazi. Inhibition of ANKRD1 sensitizes human ovarian cancer cells to endoplasmic reticulum stress-induced apoptosis. Oncogene. vol 34. issue 4. 2015-04-08. PMID:24531715. |
furthermore, we show that overexpression of ankrd1 attenuated cisplatin-induced cytotoxicity, and conversely sirna knockdown of ankrd1 sensitized ovarian cancer cells to cisplatin and er stress-induced apoptosis associated with induction of gadd153, and downregulation of bcl2 and bcl-xl. |
2015-04-08 |
2023-08-12 |
human |
| Claudia Alva-Sanchez, Adair Rodriguez, Ivan Villanueva, Brenda Anguiano, Carmen Aceves, Jorge Pacheco-Rosad. The NMDA receptor antagonist MK-801 abolishes the increase in both p53 and Bax/Bcl2 index induced by adult-onset hypothyroidism in rat. Acta neurobiologiae experimentalis. vol 74. issue 1. 2015-04-06. PMID:24718050. |
in this work we measured the expression of specific proteins that control cell proliferation (cycline-d1), cell arrest (p21), damage (p53) or apoptosis (bax and bcl2) in the hippocampus of hypothyroid rats treated with the nmda receptor (nmdar) blocker mk-801 during the induction of hypothyroidism. |
2015-04-06 |
2023-08-13 |
rat |
| Mifang Yang, Xia Shan, Xin Zhou, Tianzhu Qiu, Wei Zhu, Yin Ding, Yongqian Shu, Ping Li. miR-1271 regulates cisplatin resistance of human gastric cancer cell lines by targeting IGF1R, IRS1, mTOR, and BCL2. Anti-cancer agents in medicinal chemistry. vol 14. issue 6. 2015-03-30. PMID:24875127. |
moreover, it was down-regulated in the cisplatin-resistant gastric cancer cell line sgc7901/cisplatin (ddp) and the down-regulation of mir-1271 in sgc7901/dpp cells was accompanied by the up-regulation of insulin-like growth factor 1 receptor (igf1r)/insulin receptor substrate 1 (irs1) pathway-related proteins, i.e., igf1r, irs1, serine/threonine-protein kinase mtor (mtor), and the apoptosis regulator bcl-2 (bcl2), compared with the parental sgc7901 cells. |
2015-03-30 |
2023-08-13 |
human |
| Lisa M Lindqvist, David L Vau. BCL2 and related prosurvival proteins require BAK1 and BAX to affect autophagy. Autophagy. vol 10. issue 8. 2015-03-30. PMID:24991825. |
it is widely thought that prosurvival bcl2 family members not only inhibit apoptosis, but also block autophagy by directly binding to becn1/beclin 1. |
2015-03-30 |
2023-08-13 |
Not clear |
| Lisa M Lindqvist, David L Vau. BCL2 and related prosurvival proteins require BAK1 and BAX to affect autophagy. Autophagy. vol 10. issue 8. 2015-03-30. PMID:24991825. |
to distinguish whether bcl2, bcl2l1/bcl-xl, or mcl1 influence autophagy directly, or indirectly, through their effects on apoptosis, we compared normal cells to those lacking bax and bak1. |
2015-03-30 |
2023-08-13 |
Not clear |
| Lisa M Lindqvist, David L Vau. BCL2 and related prosurvival proteins require BAK1 and BAX to affect autophagy. Autophagy. vol 10. issue 8. 2015-03-30. PMID:24991825. |
in cells able to undergo mitochondria-mediated apoptosis, inhibiting the endogenous prosurvival bcl2 family members induces both autophagy and cell death, but when bax and bak1 are deleted, neither inhibiting nor overexpressing bcl2, bcl2l1, or mcl1 causes any detectable effect on lc3b lipidation, lc3b turnover, or autolysosome formation. |
2015-03-30 |
2023-08-13 |
Not clear |
| Won Suck Yoon, Sinyeon Kim, Sungchul Seo, Yongkeun Par. Salmonella typhimurium with γ-radiation induced H2AX phosphorylation and apoptosis in melanoma. Bioscience, biotechnology, and biochemistry. vol 78. issue 6. 2015-03-30. PMID:25036139. |
we showed that ros expression and h2ax phosphorylation increased during stress by γ-radiation irrespective of salmonella infection, inducing apoptosis by caspase-3 and bcl2 in tumor cells. |
2015-03-30 |
2023-08-13 |
Not clear |
| Li-Jun Xu, Yi-Bing Ouyang, Xiaoxing Xiong, Creed M Stary, Rona G Giffar. Post-stroke treatment with miR-181 antagomir reduces injury and improves long-term behavioral recovery in mice after focal cerebral ischemia. Experimental neurology. vol 264. 2015-03-30. PMID:25433215. |
targets affected by mir-181a antagomir administered after stroke onset include bcl2 and x-linked inhibitor of apoptosis protein (xiap). |
2015-03-30 |
2023-08-13 |
mouse |
| Yun-Han Lee, Daekwan Seo, Kyung-Ju Choi, Jesper B Andersen, Min-Ah Won, Mitsuteru Kitade, Luis E Gómez-Quiroz, Adam D Judge, Jens U Marquardt, Chiara Raggi, Elizabeth A Conner, Ian MacLachlan, Valentina M Factor, Snorri S Thorgeirsso. Antitumor effects in hepatocarcinoma of isoform-selective inhibition of HDAC2. Cancer research. vol 74. issue 17. 2015-03-17. PMID:24958469. |
these effects were associated with deregulation of hdac-regulated genes that control cell cycle, apoptosis, and lipid metabolism, specifically, by upregulation of p27 and acetylated p53 and by downregulation of cdk6 and bcl2. |
2015-03-17 |
2023-08-13 |
human |
| Sean C Patro, Sharmistha Pal, Yingtao Bi, Kenneth Lynn, Karam C Mounzer, Jay R Kostman, Ramana V Davuluri, Luis J Montane. Shift in monocyte apoptosis with increasing viral load and change in apoptosis-related ISG/Bcl2 family gene expression in chronically HIV-1-infected subjects. Journal of virology. vol 89. issue 1. 2015-03-16. PMID:25355877. |
multivariable analysis of clinical values and monocyte gene expression identified changes in ifi27, ifitm2, rb1, and bcl2 expression as determinants of constitutive apoptosis (p = 3.77 × 10(-5); adjusted r(2) = 0.5983), while changes in viral load, ifitm2, rb1, and bax expression were determinants of oxidative stress-induced apoptosis (p = 5.59 × 10(-5); adjusted r(2) = 0.5996). |
2015-03-16 |
2023-08-13 |
human |
| Duohui Jing, Vivek A Bhadri, Dominik Beck, Julie A I Thoms, Nurul A Yakob, Jason W H Wong, Kathy Knezevic, John E Pimanda, Richard B Loc. Opposing regulation of BIM and BCL2 controls glucocorticoid-induced apoptosis of pediatric acute lymphoblastic leukemia cells. Blood. vol 125. issue 2. 2015-03-11. PMID:25336632. |
opposing regulation of bim and bcl2 controls glucocorticoid-induced apoptosis of pediatric acute lymphoblastic leukemia cells. |
2015-03-11 |
2023-08-13 |
Not clear |
| Duohui Jing, Vivek A Bhadri, Dominik Beck, Julie A I Thoms, Nurul A Yakob, Jason W H Wong, Kathy Knezevic, John E Pimanda, Richard B Loc. Opposing regulation of BIM and BCL2 controls glucocorticoid-induced apoptosis of pediatric acute lymphoblastic leukemia cells. Blood. vol 125. issue 2. 2015-03-11. PMID:25336632. |
the proapoptotic bim protein is an important mediator of glucocorticoid-induced apoptosis in normal and malignant lymphocytes, whereas the antiapoptotic bcl2 confers resistance. |
2015-03-11 |
2023-08-13 |
Not clear |
| Duohui Jing, Vivek A Bhadri, Dominik Beck, Julie A I Thoms, Nurul A Yakob, Jason W H Wong, Kathy Knezevic, John E Pimanda, Richard B Loc. Opposing regulation of BIM and BCL2 controls glucocorticoid-induced apoptosis of pediatric acute lymphoblastic leukemia cells. Blood. vol 125. issue 2. 2015-03-11. PMID:25336632. |
sustained myb expression in resistant pdxs resulted in maintenance of bcl2 expression and inhibition of apoptosis. |
2015-03-11 |
2023-08-13 |
Not clear |
| Duohui Jing, Vivek A Bhadri, Dominik Beck, Julie A I Thoms, Nurul A Yakob, Jason W H Wong, Kathy Knezevic, John E Pimanda, Richard B Loc. Opposing regulation of BIM and BCL2 controls glucocorticoid-induced apoptosis of pediatric acute lymphoblastic leukemia cells. Blood. vol 125. issue 2. 2015-03-11. PMID:25336632. |
this study has identified novel mechanisms of opposing bcl2 and bim gene regulation that control glucocorticoid-induced apoptosis in pediatric all cells in vivo. |
2015-03-11 |
2023-08-13 |
Not clear |
| Ahmet Taner Sümbül, Bülent Göğebakan, Sercan Ergün, Erhan Yengil, Celal Yücel Batmacı, Önder Tonyalı, Mehmet Yaldı. miR-204-5p expression in colorectal cancer: an autophagy-associated gene. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 12. 2015-03-10. PMID:25209181. |
this may be explained by the fact that mir-204-5p increases in colorectal cancer cases in order to inhibit increased activity of lc3b-ii in autophagy and bcl2 against apoptosis posttranscriptionally and to take role as tumor suppressor. |
2015-03-10 |
2023-08-13 |
human |