| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Priyanka Bhatnagar, Soma Patnaik, Amit K Srivastava, Mohan K R Mudiam, Yogeshwer Shukla, Amulya K Panda, Aditya B Pant, Pradeep Kumar, Kailash C Gupt. Anti-cancer activity of bromelain nanoparticles by oral administration. Journal of biomedical nanotechnology. vol 10. issue 12. 2015-06-18. PMID:26000370. |
altered expression of marker proteins associated with apoptosis and cell death (p53, p21, bcl2, bax) also confirmed the enhanced anti-carcinogenic potential of formulated nps. |
2015-06-18 |
2023-08-13 |
mouse |
| J Long, Y X Su, H C Den. Lipoapoptosis pathways in pancreatic β-cells and the anti-apoptosis mechanisms of adiponectin. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 46. issue 10. 2015-06-16. PMID:25028793. |
adiponectin prevents pancreatic β-cells from apoptosis by inhibition of intrinsic apoptosis pathway via regulation of the bcl2 family. |
2015-06-16 |
2023-08-13 |
Not clear |
| Mohammad Hassan Naseri, Majid Mahdavi, Jamshid Davoodi, Saeed Hesami Tackallou, Mahdi Goudarzvand, Shima Hallaj Neishabour. Up regulation of Bax and down regulation of Bcl2 during 3-NC mediated apoptosis in human cancer cells. Cancer cell international. vol 15. 2015-06-15. PMID:26074734. |
up regulation of bax and down regulation of bcl2 during 3-nc mediated apoptosis in human cancer cells. |
2015-06-15 |
2023-08-13 |
human |
| Tanmoy Bhowmik, Partha Pratim Saha, Anjan Kumar DasGupta, Antony Gome. Influence of gold nanoparticle tagged snake venom protein toxin NKCT1 on Ehrlich ascites carcinoma (EAC) and EAC induced solid tumor bearing male albino mice. Current drug delivery. vol 11. issue 5. 2015-06-08. PMID:24827982. |
with upregulation of bax, down regulation of bcl2 and increased expression of caspase 3/9, it was confirmed that gnp-nkct1 induced caspase dependent apoptosis pathway in eac cell. |
2015-06-08 |
2023-08-13 |
mouse |
| Jinhee Kim, G K Jayaprakasha, Bhimanagouda S Pati. Obacunone exhibits anti-proliferative and anti-aromatase activity in vitro by inhibiting the p38 MAPK signaling pathway in MCF-7 human breast adenocarcinoma cells. Biochimie. vol 105. 2015-05-29. PMID:24927687. |
treatment with obacunone increased apoptosis by up-regulating expression of the pro-apoptotic protein bax and down-regulating the anti-apoptotic protein bcl2, as well as inducing g1 cell cycle arrest. |
2015-05-29 |
2023-08-13 |
human |
| Jung-Jung Changchien, Ying-Jung Chen, Chia-Hui Huang, Tian-Lu Cheng, Shinne-Ren Lin, Long-Sen Chan. Quinacrine induces apoptosis in human leukemia K562 cells via p38 MAPK-elicited BCL2 down-regulation and suppression of ERK/c-Jun-mediated BCL2L1 expression. Toxicology and applied pharmacology. vol 284. issue 1. 2015-05-20. PMID:25684043. |
quinacrine induces apoptosis in human leukemia k562 cells via p38 mapk-elicited bcl2 down-regulation and suppression of erk/c-jun-mediated bcl2l1 expression. |
2015-05-20 |
2023-08-13 |
human |
| Jung-Jung Changchien, Ying-Jung Chen, Chia-Hui Huang, Tian-Lu Cheng, Shinne-Ren Lin, Long-Sen Chan. Quinacrine induces apoptosis in human leukemia K562 cells via p38 MAPK-elicited BCL2 down-regulation and suppression of ERK/c-Jun-mediated BCL2L1 expression. Toxicology and applied pharmacology. vol 284. issue 1. 2015-05-20. PMID:25684043. |
quinacrine induced k562 cell apoptosis accompanied with ros generation, mitochondrial depolarization, and down-regulation of bcl2l1 and bcl2. |
2015-05-20 |
2023-08-13 |
human |
| Jung-Jung Changchien, Ying-Jung Chen, Chia-Hui Huang, Tian-Lu Cheng, Shinne-Ren Lin, Long-Sen Chan. Quinacrine induces apoptosis in human leukemia K562 cells via p38 MAPK-elicited BCL2 down-regulation and suppression of ERK/c-Jun-mediated BCL2L1 expression. Toxicology and applied pharmacology. vol 284. issue 1. 2015-05-20. PMID:25684043. |
taken together, our data indicate that quinacrine-induced k562 cell apoptosis is mediated through mitochondrial alterations triggered by p38 mapk-mediated bcl2 down-regulation and suppression of erk/c-jun-mediated bcl2l1 expression. |
2015-05-20 |
2023-08-13 |
human |
| Abir Chaabane, Issam M'Sakni, Manel Yahia, Fethi Bougrine, Besma Laabidi, Ramzi Khiari, Samir Ghozzi, Naoufel Berraies, Ammar Bouzian. [Prognostic value of markers of aggressiveness of urinary bladder tumours evaluated by immunohistochemistry]. La Tunisie medicale. vol 92. issue 3. 2015-05-18. PMID:24955967. |
aims: study the expression of the following immunohistochemical markers in tumours of the bladder: proliferating cell nuclear antigen (pcna), ki67 antigen (mib1), the c-erbb2 proto- antigene, the tumor suppressor gene p53, the receptor for epidermal growth factor (egf-r), the apoptosis suppressor gene bcl2, the carcinoembryonic antigen (cea) and epithelial membrane antigen (ema). |
2015-05-18 |
2023-08-13 |
Not clear |
| Hyunkeun Song, Il-Yong Han, Yeonye Kim, Young Hwan Kim, Il-Whan Choi, Su-Kil Seo, So Young Jung, SaeGwang Park, Mi Seon Kan. The NADPH oxidase inhibitor DPI can abolish hypoxia-induced apoptosis of human kidney proximal tubular epithelial cells through Bcl2 up-regulation via ERK activation without ROS reduction. Life sciences. vol 126. 2015-05-11. PMID:25744050. |
the nadph oxidase inhibitor dpi can abolish hypoxia-induced apoptosis of human kidney proximal tubular epithelial cells through bcl2 up-regulation via erk activation without ros reduction. |
2015-05-11 |
2023-08-13 |
human |
| Dongsun Park, Kyungha Shin, Ehn-Kyoung Choi, Youngjin Choi, Ja-Young Jang, Jihyun Kim, Heon-Sang Jeong, Wooryoung Lee, Yoon-Bok Lee, Seung Up Kim, Seong Soo Joo, Yun-Bae Ki. Protective effects of N-acetyl-L-cysteine in human oligodendrocyte progenitor cells and restoration of motor function in neonatal rats with hypoxic-ischemic encephalopathy. Evidence-based complementary and alternative medicine : eCAM. vol 2015. 2015-04-28. PMID:25918547. |
nac decreased kcn cytotoxicity in f3.olig2 cells and especially suppressed apoptosis by regulating bcl2 and p-erk. |
2015-04-28 |
2023-08-13 |
human |
| Achinto Saha, Jorge Blando, Eric Silver, Linda Beltran, Jonathan Sessler, John DiGiovann. 6-Shogaol from dried ginger inhibits growth of prostate cancer cells both in vitro and in vivo through inhibition of STAT3 and NF-κB signaling. Cancer prevention research (Philadelphia, Pa.). vol 7. issue 6. 2015-04-16. PMID:24691500. |
in addition, 6-sho decreased the level of several stat3 and nf-κb-regulated target genes at the protein level, including cyclin d1, survivin, and cmyc and modulated mrna levels of chemokine, cytokine, cell cycle, and apoptosis regulatory genes (il-7, ccl5, bax, bcl2, p21, and p27). |
2015-04-16 |
2023-08-13 |
mouse |
| Devora Champa, Marika A Russo, Xiao-Hui Liao, Samuel Refetoff, Ronald A Ghossein, Antonio Di Cristofan. Obatoclax overcomes resistance to cell death in aggressive thyroid carcinomas by countering Bcl2a1 and Mcl1 overexpression. Endocrine-related cancer. vol 21. issue 5. 2015-04-13. PMID:25012986. |
using primary carcinomas as well as carcinoma-derived cell lines, we also demonstrate that these tumors are intrinsically resistant to apoptosis due to high levels of expression of the bcl2 family members, bcl2a1 (bcl2a1a) and mcl1, and can be effectively targeted by obatoclax, a small-molecule pan-inhibitor of the bcl2 family. |
2015-04-13 |
2023-08-13 |
mouse |
| Xiaoxian Zhao, Juraj Bodo, Danyu Sun, Lisa Durkin, Jeffrey Lin, Mitchell R Smith, Eric D Hs. Combination of ibrutinib with ABT-199: synergistic effects on proliferation inhibition and apoptosis in mantle cell lymphoma cells through perturbation of BTK, AKT and BCL2 pathways. British journal of haematology. vol 168. issue 5. 2015-04-10. PMID:25284608. |
combination of ibrutinib with abt-199: synergistic effects on proliferation inhibition and apoptosis in mantle cell lymphoma cells through perturbation of btk, akt and bcl2 pathways. |
2015-04-10 |
2023-08-13 |
Not clear |
| Y Lei, B R Henderson, C Emmanuel, P R Harnett, A deFazi. Inhibition of ANKRD1 sensitizes human ovarian cancer cells to endoplasmic reticulum stress-induced apoptosis. Oncogene. vol 34. issue 4. 2015-04-08. PMID:24531715. |
furthermore, we show that overexpression of ankrd1 attenuated cisplatin-induced cytotoxicity, and conversely sirna knockdown of ankrd1 sensitized ovarian cancer cells to cisplatin and er stress-induced apoptosis associated with induction of gadd153, and downregulation of bcl2 and bcl-xl. |
2015-04-08 |
2023-08-12 |
human |
| Claudia Alva-Sanchez, Adair Rodriguez, Ivan Villanueva, Brenda Anguiano, Carmen Aceves, Jorge Pacheco-Rosad. The NMDA receptor antagonist MK-801 abolishes the increase in both p53 and Bax/Bcl2 index induced by adult-onset hypothyroidism in rat. Acta neurobiologiae experimentalis. vol 74. issue 1. 2015-04-06. PMID:24718050. |
in this work we measured the expression of specific proteins that control cell proliferation (cycline-d1), cell arrest (p21), damage (p53) or apoptosis (bax and bcl2) in the hippocampus of hypothyroid rats treated with the nmda receptor (nmdar) blocker mk-801 during the induction of hypothyroidism. |
2015-04-06 |
2023-08-13 |
rat |
| Mifang Yang, Xia Shan, Xin Zhou, Tianzhu Qiu, Wei Zhu, Yin Ding, Yongqian Shu, Ping Li. miR-1271 regulates cisplatin resistance of human gastric cancer cell lines by targeting IGF1R, IRS1, mTOR, and BCL2. Anti-cancer agents in medicinal chemistry. vol 14. issue 6. 2015-03-30. PMID:24875127. |
moreover, it was down-regulated in the cisplatin-resistant gastric cancer cell line sgc7901/cisplatin (ddp) and the down-regulation of mir-1271 in sgc7901/dpp cells was accompanied by the up-regulation of insulin-like growth factor 1 receptor (igf1r)/insulin receptor substrate 1 (irs1) pathway-related proteins, i.e., igf1r, irs1, serine/threonine-protein kinase mtor (mtor), and the apoptosis regulator bcl-2 (bcl2), compared with the parental sgc7901 cells. |
2015-03-30 |
2023-08-13 |
human |
| Lisa M Lindqvist, David L Vau. BCL2 and related prosurvival proteins require BAK1 and BAX to affect autophagy. Autophagy. vol 10. issue 8. 2015-03-30. PMID:24991825. |
it is widely thought that prosurvival bcl2 family members not only inhibit apoptosis, but also block autophagy by directly binding to becn1/beclin 1. |
2015-03-30 |
2023-08-13 |
Not clear |
| Lisa M Lindqvist, David L Vau. BCL2 and related prosurvival proteins require BAK1 and BAX to affect autophagy. Autophagy. vol 10. issue 8. 2015-03-30. PMID:24991825. |
to distinguish whether bcl2, bcl2l1/bcl-xl, or mcl1 influence autophagy directly, or indirectly, through their effects on apoptosis, we compared normal cells to those lacking bax and bak1. |
2015-03-30 |
2023-08-13 |
Not clear |
| Lisa M Lindqvist, David L Vau. BCL2 and related prosurvival proteins require BAK1 and BAX to affect autophagy. Autophagy. vol 10. issue 8. 2015-03-30. PMID:24991825. |
in cells able to undergo mitochondria-mediated apoptosis, inhibiting the endogenous prosurvival bcl2 family members induces both autophagy and cell death, but when bax and bak1 are deleted, neither inhibiting nor overexpressing bcl2, bcl2l1, or mcl1 causes any detectable effect on lc3b lipidation, lc3b turnover, or autolysosome formation. |
2015-03-30 |
2023-08-13 |
Not clear |