| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y Kuwano, K Nishida, K Kajita, Y Satake, Y Akaike, K Fujita, S Kano, K Masuda, K Rokuta. Transformer 2β and miR-204 regulate apoptosis through competitive binding to 3' UTR of BCL2 mRNA. Cell death and differentiation. vol 22. issue 5. 2015-12-24. PMID:25342468. |
transformer 2β and mir-204 regulate apoptosis through competitive binding to 3' utr of bcl2 mrna. |
2015-12-24 |
2023-08-13 |
human |
| Mariarosa Mazza, Marilena Hadjidemetriou, Irene de Lázaro, Cyrill Bussy, Kostas Kostarelo. Peptide nanofiber complexes with siRNA for deep brain gene silencing by stereotactic neurosurgery. ACS nano. vol 9. issue 2. 2015-12-21. PMID:25574683. |
the biological activity of the complexes was investigated in vitro by analyzing the down-regulation of the expression of a targeted protein (bcl2), as well as induction of apoptosis, as well as in vivo by analyzing the relative gene expression upon stereotactic administration into a deep rat brain structure (the subthalamic nucleus). |
2015-12-21 |
2023-08-13 |
rat |
| Baohua Sun, Bhavin Shah, Warren Fiskus, Jun Qi, Kimal Rajapakshe, Cristian Coarfa, Li Li, Santhana G T Devaraj, Sunil Sharma, Liang Zhang, Michael L Wang, Dyana T Saenz, Stephanie Krieger, James E Bradner, Kapil N Bhall. Synergistic activity of BET protein antagonist-based combinations in mantle cell lymphoma cells sensitive or resistant to ibrutinib. Blood. vol 126. issue 13. 2015-12-21. PMID:26254443. |
ba treatment also induced apoptosis of the in vitro isolated, ibrutinib-resistant mcl cells, which overexpress cdk6, bcl2, bcl-xl, xiap, and akt, but lack ibrutinib resistance-conferring btk mutation. |
2015-12-21 |
2023-08-13 |
mouse |
| Baohua Sun, Bhavin Shah, Warren Fiskus, Jun Qi, Kimal Rajapakshe, Cristian Coarfa, Li Li, Santhana G T Devaraj, Sunil Sharma, Liang Zhang, Michael L Wang, Dyana T Saenz, Stephanie Krieger, James E Bradner, Kapil N Bhall. Synergistic activity of BET protein antagonist-based combinations in mantle cell lymphoma cells sensitive or resistant to ibrutinib. Blood. vol 126. issue 13. 2015-12-21. PMID:26254443. |
cotreatment with ba and panobinostat (pan-histone deacetylase inhibitor) or palbociclib (cdk4/6 inhibitor) or abt-199 (bcl2 antagonist) synergistically induced apoptosis of the ibrutinib-resistant mcl cells. |
2015-12-21 |
2023-08-13 |
mouse |
| Joung Hyuck Joo, Eiichiro Ueda, Carl D Bortner, Xiao-Ping Yang, Grace Liao, Anton M Jette. Farnesol activates the intrinsic pathway of apoptosis and the ATF4-ATF3-CHOP cascade of ER stress in human T lymphoblastic leukemia Molt4 cells. Biochemical pharmacology. vol 97. issue 3. 2015-12-21. PMID:26275811. |
the induction of apoptosis by farnesol was inhibited by the addition of the pan-caspase inhibitor z-vad-fmk and by the exogenous expression of the anti-apoptotic protein bcl2. |
2015-12-21 |
2023-08-13 |
human |
| Jong Hye Cheong, Hyeryung Kim, Min Jee Hong, Min Hye Yang, Jung Wha Kim, Hunseung Yoo, Heejung Yang, Jeong Hill Park, Sang Hyun Sung, Hong Pyo Kim, Jinwoong Ki. Stereoisomer-specific anticancer activities of ginsenoside Rg3 and Rh2 in HepG2 cells: disparity in cytotoxicity and autophagy-inducing effects due to 20(S)-epimers. Biological & pharmaceutical bulletin. vol 38. issue 1. 2015-12-15. PMID:25744465. |
the 20(s)-forms of rg3 and rh2, but not their respective 20(r)-forms, promoted cell death in a dose-dependent manner accompanied by downregulation of bcl2 and upregulation of fas, resulting in apoptosis of hepg2 cells with poly adp ribose polymerase cleavage. |
2015-12-15 |
2023-08-13 |
Not clear |
| Mehboob Ali, Kathryn M Heyob, Markus Velten, Trent E Tipple, Lynette K Roger. DHA suppresses chronic apoptosis in the lung caused by perinatal inflammation. American journal of physiology. Lung cellular and molecular physiology. vol 309. issue 5. 2015-12-15. PMID:26138643. |
we detected substantial increases in markers of apoptosis including parp-1, apaf-1, caspase-9, bcl2, and hmgb1, and these increases were attenuated in mice that were nursed by dha-supplemented dams during the perinatal period. |
2015-12-15 |
2023-08-13 |
mouse |
| Ju Hee Oh, Jae Yoon Lee, Jin Hyeong Park, Jeong Hyeon No, Na Kyung Le. Obatoclax regulates the proliferation and fusion of osteoclast precursors through the inhibition of ERK activation by RANKL. Molecules and cells. vol 38. issue 3. 2015-12-14. PMID:25666350. |
bcl2-deficient mice have shown the importance of bcl2 in osteoclasts, as the bone mass of the mice was increased by the induced apoptosis of osteoclasts. |
2015-12-14 |
2023-08-13 |
mouse |
| Waseem Ahmad Siddiqui, Amjid Ahad, Haseeb Ahsa. The mystery of BCL2 family: Bcl-2 proteins and apoptosis: an update. Archives of toxicology. vol 89. issue 3. 2015-12-01. PMID:25618543. |
the mystery of bcl2 family: bcl-2 proteins and apoptosis: an update. |
2015-12-01 |
2023-08-13 |
Not clear |
| Varda Shoshan-Barmatz, Danya Ben-Hail, Lee Admoni, Yakov Krelin, Shambhoo Sharan Tripath. The mitochondrial voltage-dependent anion channel 1 in tumor cells. Biochimica et biophysica acta. vol 1848. issue 10 Pt B. 2015-11-24. PMID:25448878. |
apoptosis can also be regulated by vdac1, serving as an anchor point for mitochondria-interacting proteins, such as hexokinase (hk), bcl2 and bcl-xl, some of which are also highly expressed in many cancers. |
2015-11-24 |
2023-08-13 |
Not clear |
| L Li, P Pongtornpipat, T Tiutan, S L Kendrick, S Park, D O Persky, L M Rimsza, S D Puvvada, J H Schat. Synergistic induction of apoptosis in high-risk DLBCL by BCL2 inhibition with ABT-199 combined with pharmacologic loss of MCL1. Leukemia. vol 29. issue 8. 2015-11-05. PMID:25882699. |
synergistic induction of apoptosis in high-risk dlbcl by bcl2 inhibition with abt-199 combined with pharmacologic loss of mcl1. |
2015-11-05 |
2023-08-13 |
Not clear |
| L Li, P Pongtornpipat, T Tiutan, S L Kendrick, S Park, D O Persky, L M Rimsza, S D Puvvada, J H Schat. Synergistic induction of apoptosis in high-risk DLBCL by BCL2 inhibition with ABT-199 combined with pharmacologic loss of MCL1. Leukemia. vol 29. issue 8. 2015-11-05. PMID:25882699. |
avoiding apoptosis is a hallmark of cancer, and in dlbcl the redundantly functioning antiapoptotic proteins bcl2 and mcl1 are frequently expressed. |
2015-11-05 |
2023-08-13 |
Not clear |
| L Li, P Pongtornpipat, T Tiutan, S L Kendrick, S Park, D O Persky, L M Rimsza, S D Puvvada, J H Schat. Synergistic induction of apoptosis in high-risk DLBCL by BCL2 inhibition with ABT-199 combined with pharmacologic loss of MCL1. Leukemia. vol 29. issue 8. 2015-11-05. PMID:25882699. |
dinaciclib induces apoptosis in dlbcl cells but is completely overcome by increased activity of bcl2. |
2015-11-05 |
2023-08-13 |
Not clear |
| Ki Bbeum Kim, Karam Kim, Seunghee Bae, Yeonghmin Choi, Hwa Jun Cha, Soo Yeon Kim, Jae Ho Lee, So Hyeon Jeon, Ho Jung Jung, Kyu Joong Ahn, In-Sook An, Sungkwan A. MicroRNA-1290 promotes asiatic acid‑induced apoptosis by decreasing BCL2 protein level in A549 non‑small cell lung carcinoma cells. Oncology reports. vol 32. issue 3. 2015-11-03. PMID:25016979. |
microrna-1290 promotes asiatic acid‑induced apoptosis by decreasing bcl2 protein level in a549 non‑small cell lung carcinoma cells. |
2015-11-03 |
2023-08-13 |
Not clear |
| Justin M M Cates, Vincent A Memoli, Raul S Gonzale. Cell cycle and apoptosis regulatory proteins, proliferative markers, cell signaling molecules, CD209, and decorin immunoreactivity in low-grade myxofibrosarcoma and myxoma. Virchows Archiv : an international journal of pathology. vol 467. issue 2. 2015-11-03. PMID:25940995. |
ten cases each of intramuscular myxoma and low-grade myxofibrosarcoma were stained with antibodies directed against apoptosis regulatory proteins (bcl2, activated caspase-3, phospho-h2a.x, and cleaved parp), cell cycle regulatory proteins (rb1, cyclin-a, cdkn1b, and cdt1), proliferative markers (ki67, mcm2, phospho-histone h3, and geminin), cell signalling molecules (c-myc, egf, egfr, pla2g4a, and hsp90), a dendritic cell marker (cd209), and the extracellular matrix proteoglycan decorin. |
2015-11-03 |
2023-08-13 |
Not clear |
| Olatz Landeta, Ane Landajuela, Ana Garcia-Saez, Gorka Basañe. Minimalist Model Systems Reveal Similarities and Differences between Membrane Interaction Modes of MCL1 and BAK. The Journal of biological chemistry. vol 290. issue 27. 2015-10-26. PMID:25987560. |
proteins belonging to the bcl2 family are key modulators of apoptosis that establish a complex network of interactions among themselves and with other cellular factors to regulate cell fate. |
2015-10-26 |
2023-08-13 |
Not clear |
| Olatz Landeta, Ane Landajuela, Ana Garcia-Saez, Gorka Basañe. Minimalist Model Systems Reveal Similarities and Differences between Membrane Interaction Modes of MCL1 and BAK. The Journal of biological chemistry. vol 290. issue 27. 2015-10-26. PMID:25987560. |
it is well established that mitochondrial membranes are the main locus of action of all bcl2 family proteins, but it is difficult to obtain a precise view of how bcl2 family members operate at the native mitochondrial membrane environment during apoptosis. |
2015-10-26 |
2023-08-13 |
Not clear |
| Niklas Gebauer, Veronica Bernard, Wolfgang Gebauer, Christoph Thorns, Alfred C Feller, Hartmut Mer. TP53 mutations are frequent events in double-hit B-cell lymphomas with MYC and BCL2 but not MYC and BCL6 translocations. Leukemia & lymphoma. vol 56. issue 1. 2015-10-07. PMID:24679006. |
our findings indicate a significant difference between these two types of dhl at a molecular level with pathogenetic implications, as arguably, tp53 mutations inhibiting p53 mediated promotion of apoptosis pose a synergistic advantage in clonal evolution of cells with malignantly enforced overexpression of bcl2. |
2015-10-07 |
2023-08-12 |
Not clear |
| Swati Mandal, Ajeet Mandal, Myung Hee Par. Depletion of the polyamines spermidine and spermine by overexpression of spermidine/spermine N¹-acetyltransferase 1 (SAT1) leads to mitochondria-mediated apoptosis in mammalian cells. The Biochemical journal. vol 468. issue 3. 2015-10-06. PMID:25849284. |
apoptosis in the polyamine-depleted cells occurs by the mitochondrial intrinsic pathway, as evidenced by loss of mitochondrial membrane potential, increase in pro-apoptotic bax, decrease in anti-apoptotic bcl-xl, bcl2 and mcl-1 and release of cytochrome c from mitochondria, upon transduction with adsat1. |
2015-10-06 |
2023-08-13 |
human |
| Paolo Convertini, Francesco Tramutola, Vito Iacobazzi, Paolo Lupattelli, Lucia Chiummiento, Vittoria Infantin. Permethylated Anigopreissin A inhibits human hepatoma cell proliferation by mitochondria-induced apoptosis. Chemico-biological interactions. vol 237. 2015-10-06. PMID:25980588. |
decrease of the bcl2 expression levels, loss of the mitochondrial membrane potential, release of cytochrome c and increase of caspase 9 activity highlight a key role for mitochondria in permethylated anigopreissin a-induced apoptosis. |
2015-10-06 |
2023-08-13 |
human |