All Relations between apoptosis and bcl2

Publication Sentence Publish Date Extraction Date Species
Ishwari Kadariya, Jiaxing Wang, Zia ur Rehman, Hamid Ali, Hasan Riaz, JiuYa He, Dinesh Bhattarai, Jia Jia Liu, Shu Jun Zhan. RNAi-mediated knockdown of inhibin α subunit increased apoptosis in granulosa cells and decreased fertility in mice. The Journal of steroid biochemistry and molecular biology. vol 152. 2015-10-06. PMID:25998417. furthermore, suppression of inhα expression significantly promoted apoptosis by up-regulating caspase-3, bcl2, inhβb and gdf9 and down regulated kitl and tgfβriii genes both at transcriptional and translational levels. 2015-10-06 2023-08-13 mouse
Phil Jun Lee, Seung Je Woo, Jun-Goo Jee, Sang Hyun Sung, Hong Pyo Ki. Bisdemethoxycurcumin Induces apoptosis in activated hepatic stellate cells via cannabinoid receptor 2. Molecules (Basel, Switzerland). vol 20. issue 1. 2015-10-02. PMID:25594342. bdmc-induced apoptosis was mediated by a combinatory inhibition of cytoprotective proteins, such as bcl2 and heme oxygenase-1 and increased generation of reactive oxygen species. 2015-10-02 2023-08-13 Not clear
Weiming He, Yingfu Li, Jingyan Tian, Ning Jiang, Bo Du, Yuping Pen. Optimized mixture of As, Cd and Pb induce mitochondria-mediated apoptosis in C6-glioma via astroglial activation, inflammation and P38-MAPK. American journal of cancer research. vol 5. issue 8. 2015-09-23. PMID:26396915. an increase in pro-apoptotic bcl-2-associated-x protein (bax) and decrease in anti-apoptotic bcl2 resulting in a bax/bcl2 ratio > 1.0 validated mitochondrial apoptosis. 2015-09-23 2023-08-13 rat
Yang Cao, Guang Yang, Zachary R Hunter, Xia Liu, Lian Xu, Jie Chen, Nickolas Tsakmaklis, Evdoxia Hatjiharissi, Sandra Kanan, Matthew S Davids, Jorge J Castillo, Steven P Treo. The BCL2 antagonist ABT-199 triggers apoptosis, and augments ibrutinib and idelalisib mediated cytotoxicity in CXCR4 Wild-type and CXCR4 WHIM mutated Waldenstrom macroglobulinaemia cells. British journal of haematology. vol 170. issue 1. 2015-09-21. PMID:25582069. the bcl2 antagonist abt-199 triggers apoptosis, and augments ibrutinib and idelalisib mediated cytotoxicity in cxcr4 wild-type and cxcr4 whim mutated waldenstrom macroglobulinaemia cells. 2015-09-21 2023-08-13 Not clear
Qing He, Jinyun Tan, Bo Yu, Weihao Shi, Kun Lian. Long noncoding RNA HIF1A-AS1A reduces apoptosis of vascular smooth muscle cells: implications for the pathogenesis of thoracoabdominal aorta aneurysm. Die Pharmazie. vol 70. issue 5. 2015-09-21. PMID:26062299. we also found that transfection of cells with hif1a-as1 sirna decreased the expression of caspase-3 and caspase-8 and increased the expression of bcl2, and protected pa-induced cell apoptosis in vsmcs. 2015-09-21 2023-08-13 Not clear
Hiroko P Indo, Tsukasa Tomiyoshi, Shigeaki Suenaga, Kazuo Tomita, Hiromi Suzuki, Daisuke Masuda, Masahiro Terada, Noriaki Ishioka, Oleg Gusev, Richard Cornette, Takashi Okuda, Chiaki Mukai, Hideyuki J Majim. MnSOD downregulation induced by extremely low 0.1 mGy single and fractionated X-rays and microgravity treatment in human neuroblastoma cell line, NB-1. Journal of clinical biochemistry and nutrition. vol 57. issue 2. 2015-09-21. PMID:26388666. a quantitative real-time reverse transcription polymerase chain reaction (qrt-pcr) examination was performed for apoptosis related factors (bax, cytc, apaf1, vdac1-3, casp3, casp8, casp9 p53, aif, ant1 and 2, bcl2, mnsod, autophagy related becn and necrosis related cyp-40. 2015-09-21 2023-08-13 human
Suhas V Vasaikar, Sourish Ghosh, Priyam Narain, Anirban Basu, James Gome. HSP70 mediates survival in apoptotic cells-Boolean network prediction and experimental validation. Frontiers in cellular neuroscience. vol 9. 2015-09-18. PMID:26379495. further, the pro-survival role of the proteins bcl2, iap, cflip, and nfκb determined by vertex perturbation analysis was experimentally validated through protein inhibition experiments using em20-25, embelin and wedelolactone, which resulted in 1.27-, 1.26-, and 1.46-fold increase in apoptosis of n2a cells. 2015-09-18 2023-08-13 Not clear
Nathalie Allaman-Pillet, Anne Oberson, Daniel F Schordere. BIRO1, a cell-permeable BH3 peptide, promotes mitochondrial fragmentation and death of retinoblastoma cells. Molecular cancer research : MCR. vol 13. issue 1. 2015-09-16. PMID:25143432. the bh3-only proteins promote apoptosis by modulating the interaction between the pro- and antiapoptotic members of the bcl2 protein family, and this effect can be recapitulated by the bh3 domains. 2015-09-16 2023-08-13 Not clear
K Chitta, A Paulus, T R Caulfield, S Akhtar, M-K K Blake, S Ailawadhi, J Knight, M G Heckman, A Pinkerton, A Chanan-Kha. Nimbolide targets BCL2 and induces apoptosis in preclinical models of Waldenströms macroglobulinemia. Blood cancer journal. vol 4. 2015-09-16. PMID:25382610. nimbolide targets bcl2 and induces apoptosis in preclinical models of waldenströms macroglobulinemia. 2015-09-16 2023-08-13 mouse
K Chitta, A Paulus, T R Caulfield, S Akhtar, M-K K Blake, S Ailawadhi, J Knight, M G Heckman, A Pinkerton, A Chanan-Kha. Nimbolide targets BCL2 and induces apoptosis in preclinical models of Waldenströms macroglobulinemia. Blood cancer journal. vol 4. 2015-09-16. PMID:25382610. the significance of this finding was further tested in vitro in rs4;11 (bcl2-dependent) tumor cells, in which nimbolide induced significantly more apoptosis compared with bcl2 mutated (jurkat bcl2(ser70-ala)) cells. 2015-09-16 2023-08-13 mouse
Anne Benard, Connie M Janssen, Peter J van den Elsen, Marja C J A van Eggermond, Dave S B Hoon, Cornelis J H van de Velde, Peter J K Kuppe. Chromatin status of apoptosis genes correlates with sensitivity to chemo-, immune- and radiation therapy in colorectal cancer cell lines. Apoptosis : an international journal on programmed cell death. vol 19. issue 12. 2015-09-14. PMID:25292014. using chromatin immunoprecipitation (chip), we measured the presence of transcription-activating histone modifications h3ac and h3k4me3 and silencing modifications h3k9me3 and h3k27me3 at the gene promoter regions of key apoptosis genes bax, bcl2, caspase-9, fas (cd95) and p53. 2015-09-14 2023-08-13 Not clear
Anne Benard, Connie M Janssen, Peter J van den Elsen, Marja C J A van Eggermond, Dave S B Hoon, Cornelis J H van de Velde, Peter J K Kuppe. Chromatin status of apoptosis genes correlates with sensitivity to chemo-, immune- and radiation therapy in colorectal cancer cell lines. Apoptosis : an international journal on programmed cell death. vol 19. issue 12. 2015-09-14. PMID:25292014. the chromatin status of the apoptosis genes reflected the activation status of the intrinsic (bax, bcl2, caspase-9 and p53) and extrinsic (fas) pathways. 2015-09-14 2023-08-13 Not clear
Y Tatsumi, R Takano, M S Islam, T Yokochi, M Itami, Y Nakamura, A Nakagawar. BMCC1, which is an interacting partner of BCL2, attenuates AKT activity, accompanied by apoptosis. Cell death & disease. vol 6. 2015-09-11. PMID:25611382. bmcc1, which is an interacting partner of bcl2, attenuates akt activity, accompanied by apoptosis. 2015-09-11 2023-08-13 human
Y Tatsumi, R Takano, M S Islam, T Yokochi, M Itami, Y Nakamura, A Nakagawar. BMCC1, which is an interacting partner of BCL2, attenuates AKT activity, accompanied by apoptosis. Cell death & disease. vol 6. 2015-09-11. PMID:25611382. bmcc1 upregulation was correlated with the activation of forkhead box-o3a (foxo3a) (a downstream inducer of apoptosis, which is suppressed by akt) and induction of bcl2 inhibitor bim, suggesting that bmcc1 negatively regulates phosphorylation pathway of akt, resulted in apoptosis. 2015-09-11 2023-08-13 human
Marie Jung, Kathy A Gelato, Amaury Fernández-Montalván, Stephan Siegel, Bernard Haendle. Targeting BET bromodomains for cancer treatment. Epigenomics. vol 7. issue 3. 2015-09-11. PMID:26077433. this is linked to its role in modulating transcription elongation of essential genes involved in cell cycle and apoptosis such as c-myc and bcl2. 2015-09-11 2023-08-13 Not clear
Shu-e Cao, Jianmin Tian, Shengyang Chen, Xiaoran Zhang, Yongqiang Zhan. Role of miR-34c in ketamine-induced neurotoxicity in neonatal mice hippocampus. Cell biology international. vol 39. issue 2. 2015-09-10. PMID:25052764. functional assay of silencing mir-34c demonstrated that downregulation of mir-34c activated pkc-erk pathway, upregulated anti-apoptotic protein bcl2, and ameliorated ketamine-induced apoptosis in the hippocampus. 2015-09-10 2023-08-13 mouse
Karla J Hut. The role of BH3-only proteins in apoptosis within the ovary. Reproduction (Cambridge, England). vol 149. issue 2. 2015-09-02. PMID:25336346. bh3-only proteins are pro-apoptotic members of the bcl2 family that play pivotal roles in embryonic development, tissue homeostasis and immunity by triggering cell death through the intrinsic apoptosis pathway. 2015-09-02 2023-08-13 Not clear
Clifford J Cookman, Scott M Belche. Estrogen Receptor-β Up-Regulates IGF1R Expression and Activity to Inhibit Apoptosis and Increase Growth of Medulloblastoma. Endocrinology. vol 156. issue 7. 2015-08-24. PMID:25885794. the absence of esr2 resulted in increased apoptosis, decreased b-cell lymphoma 2 (bcl2), and igf-1 receptor (igf1r) expression, and decreased levels of active mapks (erk1/2) and protein kinase b (akt). 2015-08-24 2023-08-13 mouse
Clifford J Cookman, Scott M Belche. Estrogen Receptor-β Up-Regulates IGF1R Expression and Activity to Inhibit Apoptosis and Increase Growth of Medulloblastoma. Endocrinology. vol 156. issue 7. 2015-08-24. PMID:25885794. treatment of med in ptch1(+/-) trp53(-/-) mice with the antiestrogen chemotherapeutic drug faslodex significantly increased symptom-free survival, which was associated with increased apoptosis and decreased bcl2 and igf1r expression and signaling. 2015-08-24 2023-08-13 mouse
Geethu Emily Thomas, Jamuna S Sreeja, K K Gireesh, Hindol Gupta, Tapas K Mann. +TIP EB1 downregulates paclitaxel‑induced proliferation inhibition and apoptosis in breast cancer cells through inhibition of paclitaxel binding on microtubules. International journal of oncology. vol 46. issue 1. 2015-08-11. PMID:25310526. p53 and bax were upregulated and bcl2 was downregulated in the eb1‑depleted ptx‑treated mcf‑7 cells, indicating that the apoptosis occurs via a p53‑dependent pathway. 2015-08-11 2023-08-13 Not clear