| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Won Suck Yoon, Sinyeon Kim, Sungchul Seo, Yongkeun Par. Salmonella typhimurium with γ-radiation induced H2AX phosphorylation and apoptosis in melanoma. Bioscience, biotechnology, and biochemistry. vol 78. issue 6. 2015-03-30. PMID:25036139. |
we showed that ros expression and h2ax phosphorylation increased during stress by γ-radiation irrespective of salmonella infection, inducing apoptosis by caspase-3 and bcl2 in tumor cells. |
2015-03-30 |
2023-08-13 |
Not clear |
| Li-Jun Xu, Yi-Bing Ouyang, Xiaoxing Xiong, Creed M Stary, Rona G Giffar. Post-stroke treatment with miR-181 antagomir reduces injury and improves long-term behavioral recovery in mice after focal cerebral ischemia. Experimental neurology. vol 264. 2015-03-30. PMID:25433215. |
targets affected by mir-181a antagomir administered after stroke onset include bcl2 and x-linked inhibitor of apoptosis protein (xiap). |
2015-03-30 |
2023-08-13 |
mouse |
| Yun-Han Lee, Daekwan Seo, Kyung-Ju Choi, Jesper B Andersen, Min-Ah Won, Mitsuteru Kitade, Luis E Gómez-Quiroz, Adam D Judge, Jens U Marquardt, Chiara Raggi, Elizabeth A Conner, Ian MacLachlan, Valentina M Factor, Snorri S Thorgeirsso. Antitumor effects in hepatocarcinoma of isoform-selective inhibition of HDAC2. Cancer research. vol 74. issue 17. 2015-03-17. PMID:24958469. |
these effects were associated with deregulation of hdac-regulated genes that control cell cycle, apoptosis, and lipid metabolism, specifically, by upregulation of p27 and acetylated p53 and by downregulation of cdk6 and bcl2. |
2015-03-17 |
2023-08-13 |
human |
| Sean C Patro, Sharmistha Pal, Yingtao Bi, Kenneth Lynn, Karam C Mounzer, Jay R Kostman, Ramana V Davuluri, Luis J Montane. Shift in monocyte apoptosis with increasing viral load and change in apoptosis-related ISG/Bcl2 family gene expression in chronically HIV-1-infected subjects. Journal of virology. vol 89. issue 1. 2015-03-16. PMID:25355877. |
multivariable analysis of clinical values and monocyte gene expression identified changes in ifi27, ifitm2, rb1, and bcl2 expression as determinants of constitutive apoptosis (p = 3.77 × 10(-5); adjusted r(2) = 0.5983), while changes in viral load, ifitm2, rb1, and bax expression were determinants of oxidative stress-induced apoptosis (p = 5.59 × 10(-5); adjusted r(2) = 0.5996). |
2015-03-16 |
2023-08-13 |
human |
| Duohui Jing, Vivek A Bhadri, Dominik Beck, Julie A I Thoms, Nurul A Yakob, Jason W H Wong, Kathy Knezevic, John E Pimanda, Richard B Loc. Opposing regulation of BIM and BCL2 controls glucocorticoid-induced apoptosis of pediatric acute lymphoblastic leukemia cells. Blood. vol 125. issue 2. 2015-03-11. PMID:25336632. |
opposing regulation of bim and bcl2 controls glucocorticoid-induced apoptosis of pediatric acute lymphoblastic leukemia cells. |
2015-03-11 |
2023-08-13 |
Not clear |
| Duohui Jing, Vivek A Bhadri, Dominik Beck, Julie A I Thoms, Nurul A Yakob, Jason W H Wong, Kathy Knezevic, John E Pimanda, Richard B Loc. Opposing regulation of BIM and BCL2 controls glucocorticoid-induced apoptosis of pediatric acute lymphoblastic leukemia cells. Blood. vol 125. issue 2. 2015-03-11. PMID:25336632. |
the proapoptotic bim protein is an important mediator of glucocorticoid-induced apoptosis in normal and malignant lymphocytes, whereas the antiapoptotic bcl2 confers resistance. |
2015-03-11 |
2023-08-13 |
Not clear |
| Duohui Jing, Vivek A Bhadri, Dominik Beck, Julie A I Thoms, Nurul A Yakob, Jason W H Wong, Kathy Knezevic, John E Pimanda, Richard B Loc. Opposing regulation of BIM and BCL2 controls glucocorticoid-induced apoptosis of pediatric acute lymphoblastic leukemia cells. Blood. vol 125. issue 2. 2015-03-11. PMID:25336632. |
sustained myb expression in resistant pdxs resulted in maintenance of bcl2 expression and inhibition of apoptosis. |
2015-03-11 |
2023-08-13 |
Not clear |
| Duohui Jing, Vivek A Bhadri, Dominik Beck, Julie A I Thoms, Nurul A Yakob, Jason W H Wong, Kathy Knezevic, John E Pimanda, Richard B Loc. Opposing regulation of BIM and BCL2 controls glucocorticoid-induced apoptosis of pediatric acute lymphoblastic leukemia cells. Blood. vol 125. issue 2. 2015-03-11. PMID:25336632. |
this study has identified novel mechanisms of opposing bcl2 and bim gene regulation that control glucocorticoid-induced apoptosis in pediatric all cells in vivo. |
2015-03-11 |
2023-08-13 |
Not clear |
| Ahmet Taner Sümbül, Bülent Göğebakan, Sercan Ergün, Erhan Yengil, Celal Yücel Batmacı, Önder Tonyalı, Mehmet Yaldı. miR-204-5p expression in colorectal cancer: an autophagy-associated gene. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 12. 2015-03-10. PMID:25209181. |
this may be explained by the fact that mir-204-5p increases in colorectal cancer cases in order to inhibit increased activity of lc3b-ii in autophagy and bcl2 against apoptosis posttranscriptionally and to take role as tumor suppressor. |
2015-03-10 |
2023-08-13 |
human |
| Radha Munagala, Farrukh Aqil, Jeyaprakash Jeyabalan, Ramesh C Gupt. Tanshinone IIA inhibits viral oncogene expression leading to apoptosis and inhibition of cervical cancer. Cancer letters. vol 356. issue 2 Pt B. 2015-03-03. PMID:25304375. |
mechanistically in hpv positive caski cells, tan iia was found to (i) downregulate expression of hpv e6 and e7 genes and modulate associated proteins e6ap and e2f1, (ii) cause s phase cell cycle arrest, (iii) induce accumulation of p53 and alter expression of p53-dependent targets, (iv) modulate prb and related proteins, and (v) cause p53-mediated apoptosis by moderating bcl2, bax, caspase-3, and parp cleavage expressions. |
2015-03-03 |
2023-08-13 |
mouse |
| Young Rae Ji, Hei Jung Kim, Dong Hun Yu, Ki Beom Bae, Seo Jin Park, Si Jun Park, Woo Young Jang, Min-Cheol Kang, Jain Jeong, Yong Hun Sung, Minjee Choi, Taejun Park, Taesun Park, Jong Won Yun, Hyun-Shik Lee, Sanggyu Lee, Myoung Ok Kim, Zae Young Ryo. Over-expression of Roquin aggravates T cell mediated hepatitis in transgenic mice using T cell specific promoter. Biochemical and biophysical research communications. vol 452. issue 3. 2015-02-25. PMID:25201726. |
furthermore, roquin regulates the immune response and apoptosis in con a induced hepatitis via stats, bax and bcl2. |
2015-02-25 |
2023-08-13 |
mouse |
| Michelle Myers, F Hamish Morgan, Seng H Liew, Nadeen Zerafa, Thilini Upeksha Gamage, Mai Sarraj, Michele Cook, Ileana Kapic, Antony Sutherland, Clare L Scott, Andreas Strasser, Jock K Findlay, Jeffrey B Kerr, Karla J Hut. PUMA regulates germ cell loss and primordial follicle endowment in mice. Reproduction (Cambridge, England). vol 148. issue 2. 2015-02-19. PMID:24859845. |
in this study, we identified bbc3 (puma) (p53 upregulated modulator of apoptosis, also known as bcl2-binding component 3), a pro-apoptotic bh3-only protein belonging to the bcl2 family, as a critical determinant of the number of germ cells during ovarian development. |
2015-02-19 |
2023-08-13 |
mouse |
| Amy S Clark, Jinbo Chen, Shiv Kapoor, Claire Friedman, Carolyn Mies, Laura Esserman, Angela DeMichel. Pretreatment vitamin D level and response to neoadjuvant chemotherapy in women with breast cancer on the I-SPY trial (CALGB 150007/150015/ACRIN6657). Cancer medicine. vol 3. issue 3. 2015-02-12. PMID:24719175. |
secondary outcomes included biomarkers of proliferation, differentiation, and apoptosis (ki67, grade, bcl2, respectively) and 3-year relapse-free survival (rfs). |
2015-02-12 |
2023-08-13 |
Not clear |
| Mark J McCarron, Julien C Mari. TGF-β prevents T follicular helper cell accumulation and B cell autoreactivity. The Journal of clinical investigation. vol 124. issue 10. 2015-02-09. PMID:25157822. |
moreover, peripheral tfh cells escaping tgf-β control were resistant to apoptosis, exhibited high levels of the antiapoptotic protein bcl2, and remained refractory to regulation by cd8+ tregs. |
2015-02-09 |
2023-08-13 |
mouse |
| Takeshi Moriishi, Yosuke Kawai, Hisato Komori, Satoshi Rokutanda, Yutaka Eguchi, Yoshihide Tsujimoto, Izumi Asahina, Toshihisa Komor. Bcl2 deficiency activates FoxO through Akt inactivation and accelerates osteoblast differentiation. PloS one. vol 9. issue 1. 2015-01-28. PMID:24466179. |
although bcl2 subfamily proteins, including bcl2 and bcl-xl, inhibit apoptosis, the physiological significance of bcl2 in osteoblast differentiation has not been fully elucidated. |
2015-01-28 |
2023-08-12 |
mouse |
| Simon Jasinski-Bergner, Franziska Stehle, Evamaria Gonschorek, Jana Kalich, Kristin Schulz, Stefan Huettelmaier, Juliane Braun, Barbara Selige. Identification of 14-3-3β gene as a novel miR-152 target using a proteome-based approach. The Journal of biological chemistry. vol 289. issue 45. 2015-01-17. PMID:25228695. |
in contrast, the reconstitution of 14-3-3β expression in mir-152(high) cells increased the expression of the anti-apoptotic bcl2 gene, enhances the proliferative activity in the presence of the cytostatic drug paclitaxel, and causes resistance to apoptosis induced by this drug. |
2015-01-17 |
2023-08-13 |
human |
| Levi J Rupp, Brenna L Brady, Andrea C Carpenter, Maria Elena De Obaldia, Avinash Bhandoola, Remy Bosselut, Stefan A Muljo, Craig H Bassin. The microRNA biogenesis machinery modulates lineage commitment during αβ T cell development. Journal of immunology (Baltimore, Md. : 1950). vol 193. issue 8. 2015-01-07. PMID:25217159. |
expression of the antiapoptotic bcl2 protein or inactivation of the p53 proapoptotic protein rescues these thymocytes from apoptosis, increasing their frequency and permitting accumulation of cd4(+)cd8(+) αβ t cells in the periphery. |
2015-01-07 |
2023-08-13 |
Not clear |
| John L Shannonhouse, Henryk F Urbanski, Shih-Lung Woo, Li An Fong, Scott D Goddard, William F Lucas, Edward R Jones, Chaodong Wu, Caurnel Morga. Aquaporin-11 control of testicular fertility markers in Syrian hamsters. Molecular and cellular endocrinology. vol 391. issue 1-2. 2015-01-06. PMID:24791736. |
correlations were also strongest for aqp11 with expression levels of reference cdnas that control spermatogenesis (hspa2 and tnp2), steroidogenesis (cox2, 3βhsd, and srebp2), sperm motility (catsper1, pgk2, and tnp2), inflammation (cox2), and apoptosis (bax and bcl2). |
2015-01-06 |
2023-08-13 |
Not clear |
| Hongyan Sun, Guomin Zhang, Fulu Dong, Feng Wang, Wenguang Ca. Reprogramming sertoli cells into pluripotent stem cells. Cellular reprogramming. vol 16. issue 3. 2015-01-02. PMID:24802333. |
moreover, no prevented scipscs from undergoing apoptosis by activating the antiapoptotic genes bcl2 and bcl2lll, downregulating the proapoptotic genes bak1 and casp7, and blocking the activation of the proapoptotic gene bac. |
2015-01-02 |
2023-08-13 |
mouse |
| S-H Park, H-S Cho, I-J Y. Effect of bovine follicular fluid on reactive oxygen species and glutathione in oocytes, apoptosis and apoptosis-related gene expression of in vitro-produced blastocysts. Reproduction in domestic animals = Zuchthygiene. vol 49. issue 3. 2014-12-18. PMID:24592966. |
embryonic development and apoptosis, as well as the relative abundance of infτ, bax, bcl2 and hsp70 transcripts in blastocysts, were also monitored. |
2014-12-18 |
2023-08-12 |
cattle |