| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ishwari Kadariya, Jiaxing Wang, Zia ur Rehman, Hamid Ali, Hasan Riaz, JiuYa He, Dinesh Bhattarai, Jia Jia Liu, Shu Jun Zhan. RNAi-mediated knockdown of inhibin α subunit increased apoptosis in granulosa cells and decreased fertility in mice. The Journal of steroid biochemistry and molecular biology. vol 152. 2015-10-06. PMID:25998417. |
furthermore, suppression of inhα expression significantly promoted apoptosis by up-regulating caspase-3, bcl2, inhβb and gdf9 and down regulated kitl and tgfβriii genes both at transcriptional and translational levels. |
2015-10-06 |
2023-08-13 |
mouse |
| Phil Jun Lee, Seung Je Woo, Jun-Goo Jee, Sang Hyun Sung, Hong Pyo Ki. Bisdemethoxycurcumin Induces apoptosis in activated hepatic stellate cells via cannabinoid receptor 2. Molecules (Basel, Switzerland). vol 20. issue 1. 2015-10-02. PMID:25594342. |
bdmc-induced apoptosis was mediated by a combinatory inhibition of cytoprotective proteins, such as bcl2 and heme oxygenase-1 and increased generation of reactive oxygen species. |
2015-10-02 |
2023-08-13 |
Not clear |
| Weiming He, Yingfu Li, Jingyan Tian, Ning Jiang, Bo Du, Yuping Pen. Optimized mixture of As, Cd and Pb induce mitochondria-mediated apoptosis in C6-glioma via astroglial activation, inflammation and P38-MAPK. American journal of cancer research. vol 5. issue 8. 2015-09-23. PMID:26396915. |
an increase in pro-apoptotic bcl-2-associated-x protein (bax) and decrease in anti-apoptotic bcl2 resulting in a bax/bcl2 ratio > 1.0 validated mitochondrial apoptosis. |
2015-09-23 |
2023-08-13 |
rat |
| Yang Cao, Guang Yang, Zachary R Hunter, Xia Liu, Lian Xu, Jie Chen, Nickolas Tsakmaklis, Evdoxia Hatjiharissi, Sandra Kanan, Matthew S Davids, Jorge J Castillo, Steven P Treo. The BCL2 antagonist ABT-199 triggers apoptosis, and augments ibrutinib and idelalisib mediated cytotoxicity in CXCR4 Wild-type and CXCR4 WHIM mutated Waldenstrom macroglobulinaemia cells. British journal of haematology. vol 170. issue 1. 2015-09-21. PMID:25582069. |
the bcl2 antagonist abt-199 triggers apoptosis, and augments ibrutinib and idelalisib mediated cytotoxicity in cxcr4 wild-type and cxcr4 whim mutated waldenstrom macroglobulinaemia cells. |
2015-09-21 |
2023-08-13 |
Not clear |
| Qing He, Jinyun Tan, Bo Yu, Weihao Shi, Kun Lian. Long noncoding RNA HIF1A-AS1A reduces apoptosis of vascular smooth muscle cells: implications for the pathogenesis of thoracoabdominal aorta aneurysm. Die Pharmazie. vol 70. issue 5. 2015-09-21. PMID:26062299. |
we also found that transfection of cells with hif1a-as1 sirna decreased the expression of caspase-3 and caspase-8 and increased the expression of bcl2, and protected pa-induced cell apoptosis in vsmcs. |
2015-09-21 |
2023-08-13 |
Not clear |
| Hiroko P Indo, Tsukasa Tomiyoshi, Shigeaki Suenaga, Kazuo Tomita, Hiromi Suzuki, Daisuke Masuda, Masahiro Terada, Noriaki Ishioka, Oleg Gusev, Richard Cornette, Takashi Okuda, Chiaki Mukai, Hideyuki J Majim. MnSOD downregulation induced by extremely low 0.1 mGy single and fractionated X-rays and microgravity treatment in human neuroblastoma cell line, NB-1. Journal of clinical biochemistry and nutrition. vol 57. issue 2. 2015-09-21. PMID:26388666. |
a quantitative real-time reverse transcription polymerase chain reaction (qrt-pcr) examination was performed for apoptosis related factors (bax, cytc, apaf1, vdac1-3, casp3, casp8, casp9 p53, aif, ant1 and 2, bcl2, mnsod, autophagy related becn and necrosis related cyp-40. |
2015-09-21 |
2023-08-13 |
human |
| Suhas V Vasaikar, Sourish Ghosh, Priyam Narain, Anirban Basu, James Gome. HSP70 mediates survival in apoptotic cells-Boolean network prediction and experimental validation. Frontiers in cellular neuroscience. vol 9. 2015-09-18. PMID:26379495. |
further, the pro-survival role of the proteins bcl2, iap, cflip, and nfκb determined by vertex perturbation analysis was experimentally validated through protein inhibition experiments using em20-25, embelin and wedelolactone, which resulted in 1.27-, 1.26-, and 1.46-fold increase in apoptosis of n2a cells. |
2015-09-18 |
2023-08-13 |
Not clear |
| Nathalie Allaman-Pillet, Anne Oberson, Daniel F Schordere. BIRO1, a cell-permeable BH3 peptide, promotes mitochondrial fragmentation and death of retinoblastoma cells. Molecular cancer research : MCR. vol 13. issue 1. 2015-09-16. PMID:25143432. |
the bh3-only proteins promote apoptosis by modulating the interaction between the pro- and antiapoptotic members of the bcl2 protein family, and this effect can be recapitulated by the bh3 domains. |
2015-09-16 |
2023-08-13 |
Not clear |
| K Chitta, A Paulus, T R Caulfield, S Akhtar, M-K K Blake, S Ailawadhi, J Knight, M G Heckman, A Pinkerton, A Chanan-Kha. Nimbolide targets BCL2 and induces apoptosis in preclinical models of Waldenströms macroglobulinemia. Blood cancer journal. vol 4. 2015-09-16. PMID:25382610. |
nimbolide targets bcl2 and induces apoptosis in preclinical models of waldenströms macroglobulinemia. |
2015-09-16 |
2023-08-13 |
mouse |
| K Chitta, A Paulus, T R Caulfield, S Akhtar, M-K K Blake, S Ailawadhi, J Knight, M G Heckman, A Pinkerton, A Chanan-Kha. Nimbolide targets BCL2 and induces apoptosis in preclinical models of Waldenströms macroglobulinemia. Blood cancer journal. vol 4. 2015-09-16. PMID:25382610. |
the significance of this finding was further tested in vitro in rs4;11 (bcl2-dependent) tumor cells, in which nimbolide induced significantly more apoptosis compared with bcl2 mutated (jurkat bcl2(ser70-ala)) cells. |
2015-09-16 |
2023-08-13 |
mouse |
| Anne Benard, Connie M Janssen, Peter J van den Elsen, Marja C J A van Eggermond, Dave S B Hoon, Cornelis J H van de Velde, Peter J K Kuppe. Chromatin status of apoptosis genes correlates with sensitivity to chemo-, immune- and radiation therapy in colorectal cancer cell lines. Apoptosis : an international journal on programmed cell death. vol 19. issue 12. 2015-09-14. PMID:25292014. |
using chromatin immunoprecipitation (chip), we measured the presence of transcription-activating histone modifications h3ac and h3k4me3 and silencing modifications h3k9me3 and h3k27me3 at the gene promoter regions of key apoptosis genes bax, bcl2, caspase-9, fas (cd95) and p53. |
2015-09-14 |
2023-08-13 |
Not clear |
| Anne Benard, Connie M Janssen, Peter J van den Elsen, Marja C J A van Eggermond, Dave S B Hoon, Cornelis J H van de Velde, Peter J K Kuppe. Chromatin status of apoptosis genes correlates with sensitivity to chemo-, immune- and radiation therapy in colorectal cancer cell lines. Apoptosis : an international journal on programmed cell death. vol 19. issue 12. 2015-09-14. PMID:25292014. |
the chromatin status of the apoptosis genes reflected the activation status of the intrinsic (bax, bcl2, caspase-9 and p53) and extrinsic (fas) pathways. |
2015-09-14 |
2023-08-13 |
Not clear |
| Y Tatsumi, R Takano, M S Islam, T Yokochi, M Itami, Y Nakamura, A Nakagawar. BMCC1, which is an interacting partner of BCL2, attenuates AKT activity, accompanied by apoptosis. Cell death & disease. vol 6. 2015-09-11. PMID:25611382. |
bmcc1, which is an interacting partner of bcl2, attenuates akt activity, accompanied by apoptosis. |
2015-09-11 |
2023-08-13 |
human |
| Y Tatsumi, R Takano, M S Islam, T Yokochi, M Itami, Y Nakamura, A Nakagawar. BMCC1, which is an interacting partner of BCL2, attenuates AKT activity, accompanied by apoptosis. Cell death & disease. vol 6. 2015-09-11. PMID:25611382. |
bmcc1 upregulation was correlated with the activation of forkhead box-o3a (foxo3a) (a downstream inducer of apoptosis, which is suppressed by akt) and induction of bcl2 inhibitor bim, suggesting that bmcc1 negatively regulates phosphorylation pathway of akt, resulted in apoptosis. |
2015-09-11 |
2023-08-13 |
human |
| Marie Jung, Kathy A Gelato, Amaury Fernández-Montalván, Stephan Siegel, Bernard Haendle. Targeting BET bromodomains for cancer treatment. Epigenomics. vol 7. issue 3. 2015-09-11. PMID:26077433. |
this is linked to its role in modulating transcription elongation of essential genes involved in cell cycle and apoptosis such as c-myc and bcl2. |
2015-09-11 |
2023-08-13 |
Not clear |
| Shu-e Cao, Jianmin Tian, Shengyang Chen, Xiaoran Zhang, Yongqiang Zhan. Role of miR-34c in ketamine-induced neurotoxicity in neonatal mice hippocampus. Cell biology international. vol 39. issue 2. 2015-09-10. PMID:25052764. |
functional assay of silencing mir-34c demonstrated that downregulation of mir-34c activated pkc-erk pathway, upregulated anti-apoptotic protein bcl2, and ameliorated ketamine-induced apoptosis in the hippocampus. |
2015-09-10 |
2023-08-13 |
mouse |
| Karla J Hut. The role of BH3-only proteins in apoptosis within the ovary. Reproduction (Cambridge, England). vol 149. issue 2. 2015-09-02. PMID:25336346. |
bh3-only proteins are pro-apoptotic members of the bcl2 family that play pivotal roles in embryonic development, tissue homeostasis and immunity by triggering cell death through the intrinsic apoptosis pathway. |
2015-09-02 |
2023-08-13 |
Not clear |
| Clifford J Cookman, Scott M Belche. Estrogen Receptor-β Up-Regulates IGF1R Expression and Activity to Inhibit Apoptosis and Increase Growth of Medulloblastoma. Endocrinology. vol 156. issue 7. 2015-08-24. PMID:25885794. |
the absence of esr2 resulted in increased apoptosis, decreased b-cell lymphoma 2 (bcl2), and igf-1 receptor (igf1r) expression, and decreased levels of active mapks (erk1/2) and protein kinase b (akt). |
2015-08-24 |
2023-08-13 |
mouse |
| Clifford J Cookman, Scott M Belche. Estrogen Receptor-β Up-Regulates IGF1R Expression and Activity to Inhibit Apoptosis and Increase Growth of Medulloblastoma. Endocrinology. vol 156. issue 7. 2015-08-24. PMID:25885794. |
treatment of med in ptch1(+/-) trp53(-/-) mice with the antiestrogen chemotherapeutic drug faslodex significantly increased symptom-free survival, which was associated with increased apoptosis and decreased bcl2 and igf1r expression and signaling. |
2015-08-24 |
2023-08-13 |
mouse |
| Geethu Emily Thomas, Jamuna S Sreeja, K K Gireesh, Hindol Gupta, Tapas K Mann. +TIP EB1 downregulates paclitaxel‑induced proliferation inhibition and apoptosis in breast cancer cells through inhibition of paclitaxel binding on microtubules. International journal of oncology. vol 46. issue 1. 2015-08-11. PMID:25310526. |
p53 and bax were upregulated and bcl2 was downregulated in the eb1‑depleted ptx‑treated mcf‑7 cells, indicating that the apoptosis occurs via a p53‑dependent pathway. |
2015-08-11 |
2023-08-13 |
Not clear |