| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Saeid Ghavami, Pawan Sharma, Behzad Yeganeh, Oluwaseun O Ojo, Aruni Jha, Mark M Mutawe, Hessam H Kashani, Marek J Los, Thomas Klonisch, Helmut Unruh, Andrew J Halayk. Airway mesenchymal cell death by mevalonate cascade inhibition: integration of autophagy, unfolded protein response and apoptosis focusing on Bcl2 family proteins. Biochimica et biophysica acta. vol 1843. issue 7. 2014-06-30. PMID:24637330. |
airway mesenchymal cell death by mevalonate cascade inhibition: integration of autophagy, unfolded protein response and apoptosis focusing on bcl2 family proteins. |
2014-06-30 |
2023-08-12 |
human |
| G Schlossmacher, E Platt, A Davies, S Meredith, A Whit. Glucocorticoid receptor-mediated apoptosis in small-cell lung cancer requires interaction with BCL2. Endocrine-related cancer. vol 20. issue 6. 2014-06-26. PMID:24036132. |
glucocorticoid receptor-mediated apoptosis in small-cell lung cancer requires interaction with bcl2. |
2014-06-26 |
2023-08-12 |
Not clear |
| G Schlossmacher, E Platt, A Davies, S Meredith, A Whit. Glucocorticoid receptor-mediated apoptosis in small-cell lung cancer requires interaction with BCL2. Endocrine-related cancer. vol 20. issue 6. 2014-06-26. PMID:24036132. |
the anti-apoptotic bcl2 gene was significantly overexpressed in six sclc cell lines and the bcl2 inhibitor abt-737 increased apoptosis in all three cell lines tested. |
2014-06-26 |
2023-08-12 |
Not clear |
| G Schlossmacher, E Platt, A Davies, S Meredith, A Whit. Glucocorticoid receptor-mediated apoptosis in small-cell lung cancer requires interaction with BCL2. Endocrine-related cancer. vol 20. issue 6. 2014-06-26. PMID:24036132. |
gr interacted with bcl2 in dms 153, dms 79 and cor-l42 cell lines, suggesting that a protein interaction between gr and bcl2 could play a role in gr-induced apoptosis. |
2014-06-26 |
2023-08-12 |
Not clear |
| Maisa Mahmoud Ali Kamkar, Rasheed Ahmad, Osama Alsmadi, Kazem Behbehan. Insight into the impact of diabetes mellitus on the increased risk of hepatocellular carcinoma: mini-review. Journal of diabetes and metabolic disorders. vol 13. 2014-06-24. PMID:24918094. |
the first approach is to look at the role of inflammatory mediators (tnf-α and il-6) in apoptosis and inflammation during hepatocarcinogenesis through monitoring levels of apoptotic regulators, b-cell lymphoma 2 protein which is encoded by bcl2 gene and apoptosis regulator bax known as bcl-2-like protein 4 which is encoded by the bax gene. |
2014-06-24 |
2023-08-13 |
Not clear |
| K Yang, J Wang, A P Xiang, X Zhan, Y Wang, M Wu, X Huan. Functional RIG-I-like receptors control the survival of mesenchymal stem cells. Cell death & disease. vol 4. 2014-06-12. PMID:24336087. |
moreover, neither overexpression of b-cell lymphoma 2 (bcl2) nor neutralizing autocrined ifn-β reduced rlr-mediated apoptosis. |
2014-06-12 |
2023-08-12 |
Not clear |
| Benjamin T Kil. The role of apoptosis in megakaryocytes and platelets. British journal of haematology. vol 165. issue 2. 2014-06-09. PMID:24467740. |
this has been driven by the advent of bh3 mimetic drugs that target bcl2 family proteins to induce apoptosis in tumour cells: agents such as abt-263 (navitoclax, which targets bcl2, bcl-xl [bcl2l1] and bcl2l2) and abt-199 (a bcl2-specific agent) are showing great promise in early stage clinical trials. |
2014-06-09 |
2023-08-12 |
Not clear |
| Ylermi Soini, M Eskelinen, P Juvonen, V Kärjä, K M Haapasaari, A Saarela, P Karihtal. Strong claudin 5 expression is a poor prognostic sign in pancreatic adenocarcinoma. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 4. 2014-06-09. PMID:24519061. |
the results were correlated with patient prognosis, with claudin 5 expression in blood vessels, with the expression level of bcl2 and bax and with apoptosis. |
2014-06-09 |
2023-08-12 |
Not clear |
| Agata Grazia D'Amico, Soraya Scuderi, Salvatore Saccone, Alessandro Castorina, Filippo Drago, Velia D'Agat. Antiproliferative effects of PACAP and VIP in serum-starved glioma cells. Journal of molecular neuroscience : MN. vol 51. issue 2. 2014-05-30. PMID:23900722. |
cell viability, expression of proteins related to cell proliferation (cyclin d1), apoptosis (bcl2, p53, and cleaved caspase-3), and cell malignancy (gfap and nestin) were assessed by mtt assay, immunoblot, and immunolocalization, respectively. |
2014-05-30 |
2023-08-12 |
Not clear |
| Elżbieta Płuciennik, Katarzyna Kośla, Katarzyna Wójcik-Krowiranda, Andrzej Bieńkiewicz, Andrzej K Bednare. The WWOX tumor suppressor gene in endometrial adenocarcinoma. International journal of molecular medicine. vol 32. issue 6. 2014-05-27. PMID:24126431. |
quantitative pcr was used to assess the correlation between the expression levels of wwox and the genes involved in the proliferation (mki67), apoptosis (bax, bcl2), signal transduction (egfr), cell cycle (ccne1, ccnd1), cell adhesion (cdh1) and transcription regulation (tp73, ncor1). |
2014-05-27 |
2023-08-12 |
Not clear |
| K Kurokawa, Y Akaike, K Masuda, Y Kuwano, K Nishida, N Yamagishi, K Kajita, T Tanahashi, K Rokuta. Downregulation of serine/arginine-rich splicing factor 3 induces G1 cell cycle arrest and apoptosis in colon cancer cells. Oncogene. vol 33. issue 11. 2014-05-15. PMID:23503458. |
the knockdown also induced apoptosis in association with reduction of bcl2 protein levels. |
2014-05-15 |
2023-08-12 |
Not clear |
| Miki Kiyota, Junya Kuroda, Mio Yamamoto-Sugitani, Yuji Shimura, Ryuko Nakayama, Hisao Nagoshi, Shinsuke Mizutani, Yoshiaki Chinen, Nana Sasaki, Natsumi Sakamoto, Tsutomu Kobayashi, Yosuke Matsumoto, Shigeo Horiike, Masafumi Taniwak. FTY720 induces apoptosis of chronic myelogenous leukemia cells via dual activation of BIM and BID and overcomes various types of resistance to tyrosine kinase inhibitors. Apoptosis : an international journal on programmed cell death. vol 18. issue 11. 2014-05-08. PMID:23851982. |
enforced expression of either bcl2 or the dominant-negative protein of fadd (fadd.dn) partly protected cml cells from apoptosis by fty720, indicating the involvement of both cell extrinsic and intrinsic apoptosis pathways. |
2014-05-08 |
2023-08-12 |
Not clear |
| Miki Kiyota, Junya Kuroda, Mio Yamamoto-Sugitani, Yuji Shimura, Ryuko Nakayama, Hisao Nagoshi, Shinsuke Mizutani, Yoshiaki Chinen, Nana Sasaki, Natsumi Sakamoto, Tsutomu Kobayashi, Yosuke Matsumoto, Shigeo Horiike, Masafumi Taniwak. FTY720 induces apoptosis of chronic myelogenous leukemia cells via dual activation of BIM and BID and overcomes various types of resistance to tyrosine kinase inhibitors. Apoptosis : an international journal on programmed cell death. vol 18. issue 11. 2014-05-08. PMID:23851982. |
gene knockdown of either bim or bid partly protected k562 cells from apoptosis by fty720, but the extent of cell protection was not as much as that by overexpression of either bcl2 or fadd.dn. |
2014-05-08 |
2023-08-12 |
Not clear |
| James Q Wang, Yogesh S Jeelall, Bruce Beutler, Keisuke Horikawa, Christopher C Goodno. Consequences of the recurrent MYD88(L265P) somatic mutation for B cell tolerance. The Journal of experimental medicine. vol 211. issue 3. 2014-05-07. PMID:24534189. |
myd88(l265p) caused self-reactive b cells to accumulate in vivo only when apoptosis was opposed by bcl2 overexpression. |
2014-05-07 |
2023-08-12 |
Not clear |
| Tian-Quan Yang, Xiao-Jun Lu, Ting-Feng Wu, Da-Dong Ding, Zhao-Hui Zhao, Gui-Lin Chen, Xue-Shun Xie, Bin Li, Yong-Xin Wei, Ling-Chuan Guo, Yu Zhang, Yu-Lun Huang, You-Xin Zhou, Zi-Wei D. MicroRNA-16 inhibits glioma cell growth and invasion through suppression of BCL2 and the nuclear factor-κB1/MMP9 signaling pathway. Cancer science. vol 105. issue 3. 2014-05-06. PMID:24418124. |
our results also indicated that upregulation of mir-16 promoted apoptosis by suppressing bcl2 expression. |
2014-05-06 |
2023-08-12 |
mouse |
| M Scherr, A Elder, K Battmer, D Barzan, S Bomken, M Ricke-Hoch, A Schröder, L Venturini, H J Blair, J Vormoor, O Ottmann, A Ganser, A Pich, D Hilfiker-Kleiner, O Heidenreich, M Ede. Differential expression of miR-17~92 identifies BCL2 as a therapeutic target in BCR-ABL-positive B-lineage acute lymphoblastic leukemia. Leukemia. vol 28. issue 3. 2014-04-30. PMID:24280866. |
we validated bcl2 as a direct target of this mirna cluster in mice and humans, and, similar to mir-17~19b overexpression, bcl2-specific rnai strongly induced apoptosis in bcr-abl-positive cells. |
2014-04-30 |
2023-08-12 |
mouse |
| M Scherr, A Elder, K Battmer, D Barzan, S Bomken, M Ricke-Hoch, A Schröder, L Venturini, H J Blair, J Vormoor, O Ottmann, A Ganser, A Pich, D Hilfiker-Kleiner, O Heidenreich, M Ede. Differential expression of miR-17~92 identifies BCL2 as a therapeutic target in BCR-ABL-positive B-lineage acute lymphoblastic leukemia. Leukemia. vol 28. issue 3. 2014-04-30. PMID:24280866. |
these data demonstrate the role of mir-17~92 in regulation of apoptosis, and identify bcl2 as a therapeutic target of particular relevance in bcr-abl-positive all. |
2014-04-30 |
2023-08-12 |
mouse |
| Carlos Giovanni Silva-García, Rosa Estela Navarr. The C. elegans TIA-1/TIAR homolog TIAR-1 is required to induce germ cell apoptosis. Genesis (New York, N.Y. : 2000). vol 51. issue 10. 2014-04-25. PMID:23913578. |
we also show that tiar-1 acts downstream of ced-9 (a bcl2 homolog) to induce apoptosis under stress conditions, and apparently does not seem to regulate ced-4 or ced-3 mrnas accumulation directly. |
2014-04-25 |
2023-08-12 |
caenorhabditis_elegans |
| Anastasia Wyce, Gopinath Ganji, Kimberly N Smitheman, Chun-Wa Chung, Susan Korenchuk, Yuchen Bai, Olena Barbash, BaoChau Le, Peter D Craggs, Michael T McCabe, Karen M Kennedy-Wilson, Lydia V Sanchez, Romain L Gosmini, Nigel Parr, Charles F McHugh, Dashyant Dhanak, Rab K Prinjha, Kurt R Auger, Peter J Tummin. BET inhibition silences expression of MYCN and BCL2 and induces cytotoxicity in neuroblastoma tumor models. PloS one. vol 8. issue 8. 2014-04-16. PMID:24009722. |
gene expression analyses in neuroblastoma cell lines suggest a role of bet inhibition in apoptosis, signaling, and n-myc-driven pathways, including the direct suppression of bcl2 and mycn. |
2014-04-16 |
2023-08-12 |
mouse |
| Andrew W Taylo. Alpha-melanocyte stimulating hormone (α-MSH) is a post-caspase suppressor of apoptosis in RAW 264.7 macrophages. PloS one. vol 8. issue 8. 2014-04-16. PMID:24009773. |
since there is little know about α-msh as an anti-apoptotic factor, the effects of α-msh on caspase activity, mitochondrial membrane potential, bcl2 to bax expression, along with tunel staining, and annexin v binding were examined in raw 264.7 macrophages under serum-starved conditions that trigger apoptosis. |
2014-04-16 |
2023-08-12 |
Not clear |