| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Meike Vogler, David Dinsdale, Martin J S Dyer, Gerald M Cohe. ABT-199 selectively inhibits BCL2 but not BCL2L1 and efficiently induces apoptosis of chronic lymphocytic leukaemic cells but not platelets. British journal of haematology. vol 163. issue 1. 2013-11-26. PMID:23826785. |
abt-199 selectively inhibits bcl2 but not bcl2l1 and efficiently induces apoptosis of chronic lymphocytic leukaemic cells but not platelets. |
2013-11-26 |
2023-08-12 |
Not clear |
| Hong Liu, Su Mi, Zhe Li, Fang Hua, Zhuo-Wei H. Interleukin 17A inhibits autophagy through activation of PIK3CA to interrupt the GSK3B-mediated degradation of BCL2 in lung epithelial cells. Autophagy. vol 9. issue 5. 2013-11-22. PMID:23514933. |
here we report that the phosphorylation of b-cell cll/lymphoma 2 (bcl2), an apoptosis regulatory protein, was inhibited in the presence of il17a in lung epithelial cells, and this reduction suppressed the ubiquitination degradation of bcl2, which subsequently attenuated autophagy by promoting the interaction of bcl2 and becn1. |
2013-11-22 |
2023-08-12 |
Not clear |
| S V Mehta, S N Shukla, H H Vor. Overexpression of Bcl2 protein predicts chemoresistance in acute myeloid leukemia: its correlation with FLT3. Neoplasma. vol 60. issue 6. 2013-11-14. PMID:23906301. |
deregulation of apoptosis is one of the important features of aml and to understand the molecular mechanism underlying apoptosis and its contribution to tumor progression, this study aimed to evaluate anti-apoptotic bcl2 protein expression in aml and correlate with flt3 parameters for their role in prognosis of disease.bcl2 and flt3 protein expression was quantified by flow cytometry on leukemic blasts in total 174 de novo aml, myelodysplastic syndrome (mds) and aplastic anemia patients. |
2013-11-14 |
2023-08-12 |
Not clear |
| Ying Wang, Shao-Lin Xu, Ya-Zhen Wu, Mei-Sheng Zhao, Wen-Jing Xu, Hai-Yan Yang, Yu-Xin L. Simvastatin induces caspase-dependent apoptosis and activates P53 in OCM-1 cells. Experimental eye research. vol 113. 2013-11-07. PMID:23727160. |
in addition, simvastatin resulted in an increase in levels of reactive oxygen species (ros) in ocm-1 cells and simvastatin significantly triggered apoptosis in ocm-1 cells, which was characterized by increased chromatin condensation, activation of caspase-9 and cleaved-caspase-3, increased expression mitochondrion-related apoptosis protein of p53, bax and decreased expression of bcl2 and iaspp. |
2013-11-07 |
2023-08-12 |
Not clear |
| Wei Wang, Fang Gu, Cai Wei, Yigui Tang, Xin Zheng, Mingqiang Ren, Yide Qi. PGPIPN, a therapeutic hexapeptide, suppressed human ovarian cancer growth by targeting BCL2. PloS one. vol 8. issue 4. 2013-11-05. PMID:23593287. |
further study demonstrated that the anti-tumor effect of pgpipn is partially through promoting cell apoptosis by inhibiting bcl2 pathway. |
2013-11-05 |
2023-08-12 |
mouse |
| Prevost Bi-Koffi Kouamé, Camille Jacques, Gustave Bedi, Virginie Silvestre, Denis Loquet, Sophie Barillé-Nion, Richard J Robins, Illa Te. Phytochemicals isolated from leaves of Chromolaena odorata: impact on viability and clonogenicity of cancer cell lines. Phytotherapy research : PTR. vol 27. issue 6. 2013-10-24. PMID:22899281. |
2'-hydroxy-4,4',5',6'-tetramethoxychalcone was found to be both cytotoxic and anticlonogenic at 20 µm in cell lines cal51, mcf7 and mdamb-468, and to act synergistically with the bcl2 inhibitor abt737 to enhance apoptosis in cal51 breast cancer cells. |
2013-10-24 |
2023-08-12 |
Not clear |
| Chengmeng Jin, Wei Yu, Xiaoyan Lou, Fan Zhou, Xu Han, Na Zhao, Biaoyang Li. UCHL1 Is a Putative Tumor Suppressor in Ovarian Cancer Cells and Contributes to Cisplatin Resistance. Journal of Cancer. vol 4. issue 8. 2013-10-24. PMID:24155778. |
several apoptosis related genes were increased after uchl1 knockdown, including apoptosis regulator bcl2, bcl11a, aen and xiap. |
2013-10-24 |
2023-08-12 |
Not clear |
| Jessica L Schwartz-Roberts, Ayesha N Shajahan, Katherine L Cook, Anni Wärri, Mones Abu-Asab, Robert Clark. GX15-070 (obatoclax) induces apoptosis and inhibits cathepsin D- and L-mediated autophagosomal lysis in antiestrogen-resistant breast cancer cells. Molecular cancer therapeutics. vol 12. issue 4. 2013-10-22. PMID:23395885. |
thus, gx15-070 has dual roles in promoting cell death: (i) directly inhibiting antiapoptotic bcl2 family members, thereby inducing apoptosis; and (ii) inhibiting downstream ctsd and ctsl1 protein expression to limit the ability of cells to use degraded material to fuel cellular metabolism and restore homeostasis. |
2013-10-22 |
2023-08-12 |
Not clear |
| Zheng Li, Hui-Ying Qiu, Yang Jiao, Jian-Nong Cen, Chun-Mei Fu, Shao-Yan Hu, Ming-Qing Zhu, De-Pei Wu, Xiao-Fei Q. Growth and differentiation effects of Homer3 on a leukemia cell line. Asian Pacific journal of cancer prevention : APJCP. vol 14. issue 4. 2013-10-22. PMID:23725168. |
forced expression of homer3 in transfected k562 cells inhibited proliferation, influenced the cell cycle profile, affected apoptosis induced by as2o3 through inhibition of bcl2 expression, and also promoted cell differentiation induced by 12-o-tetra decanoylphorbol-acetate (tpa). |
2013-10-22 |
2023-08-12 |
Not clear |
| Hongfu Xie, Fangfen Liu, Leishan Liu, Jian Dan, Ying Luo, Yuxin Yi, Xiang Chen, Ji L. Protective role of AQP3 in UVA-induced NHSFs apoptosis via Bcl2 up-regulation. Archives of dermatological research. vol 305. issue 5. 2013-10-21. PMID:23463292. |
protective role of aqp3 in uva-induced nhsfs apoptosis via bcl2 up-regulation. |
2013-10-21 |
2023-08-12 |
human |
| Xiaoming Yang, Yali Xu, Fenghua Guo, Yanxia Ning, Xiuling Zhi, Lianhua Yin, Xiaobo L. Hydroxysteroid sulfotransferase SULT2B1b promotes hepatocellular carcinoma cells proliferation in vitro and in vivo. PloS one. vol 8. issue 4. 2013-10-17. PMID:23593328. |
likewise, inhibition of sult2b1b expression induced cell-cycle arrest and apoptosis in hepa1-6 cells by upregulating the expression of fas, downregulating the expression of cyclinb1, bcl2 and myc in vitro and in vivo at both the transcript and protein levels. |
2013-10-17 |
2023-08-12 |
mouse |
| Nancy C Reic. A death-promoting role for ISG54/IFIT2. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. vol 33. issue 4. 2013-09-30. PMID:23570386. |
expression of this protein has been found to promote cellular apoptosis by a mitochondrial pathway dependent on the action of bcl2 proteins. |
2013-09-30 |
2023-08-12 |
Not clear |
| Ming-Hui Zou, Zhonglin Xi. Regulation of interplay between autophagy and apoptosis in the diabetic heart: new role of AMPK. Autophagy. vol 9. issue 4. 2013-09-24. PMID:23380689. |
activation of ampk directly phosphorylates mapk8, which mediates bcl2 phosphorylation and subsequent becn1-bcl2 dissociation, leading to restoration of cardiac autophagy, protection against cardiac apoptosis, and ultimately improvement in cardiac structure and function. |
2013-09-24 |
2023-08-12 |
Not clear |
| Ming-Hui Zou, Zhonglin Xi. Regulation of interplay between autophagy and apoptosis in the diabetic heart: new role of AMPK. Autophagy. vol 9. issue 4. 2013-09-24. PMID:23380689. |
we conclude that dissociation of bcl2 from becn1 through activation of mapk8-bcl2 signaling may be an important mechanism by which ampk activation restores autophagy, protects against cardiac apoptosis, and prevents diabetic cardiomyopathy. |
2013-09-24 |
2023-08-12 |
Not clear |
| Jesus A F Tresguerres, Roman Kireev, Katherine Forman, Sara Cuesta, Ana F Tresguerres, Elena Var. Effect of chronic melatonin administration on several physiological parameters from old Wistar rats and SAMP8 mice. Current aging science. vol 5. issue 3. 2013-09-24. PMID:23387890. |
after treatment, the expression of inflammatory mediators (tumor necrosis factor-α, interleukin 1 and 10, nfκbp50 and nfκbp52), apoptosis markers (bad, bax, and bcl2), and parameters related to oxidative stress (heme oxygenases 1 and 2, endothelial and inducible nitric oxide synthases) were determined in the heart. |
2013-09-24 |
2023-08-12 |
mouse |
| Yunhua Zhu, Yi-Fu Huang, Calvina Kek, Dmitry V Bulavi. Apoptosis differently affects lineage tracing of Lgr5 and Bmi1 intestinal stem cell populations. Cell stem cell. vol 12. issue 3. 2013-09-05. PMID:23415913. |
in turn, when we suppressed apoptosis by either bcl2 overexpression or chk2 deletion, we found that lineage tracing of lgr5-positive cells was efficiently reduced. |
2013-09-05 |
2023-08-12 |
mouse |
| B Hernaez, M Cabezas, R Muñoz-Moreno, I Galindo, M A Cuesta-Geijo, C Alons. A179L, a new viral Bcl2 homolog targeting Beclin 1 autophagy related protein. Current molecular medicine. vol 13. issue 2. 2013-09-04. PMID:23228131. |
a179l, the viral bcl2 homolog of african swine fever virus, interacts with proapoptotic bcl2 family proteins to inhibit apoptosis. |
2013-09-04 |
2023-08-12 |
Not clear |
| Hoyun Choi, Hanna Lee, Sae Rom Kim, Yong Song Gho, Suk Kyeong Le. Epstein-Barr virus-encoded microRNA BART15-3p promotes cell apoptosis partially by targeting BRUCE. Journal of virology. vol 87. issue 14. 2013-09-04. PMID:23678170. |
using bioinformatic analyses, we predicted that mir-bart15-3p may target the antiapoptotic b-cell lymphoma 2 (bcl2), bcl2l2, dead (asp-glu-ala-asp) box polypeptide 42 (ddx42), and baculovirus inhibitor of apoptosis repeat-containing ubiquitin-conjugating enzyme (bruce) mrnas. |
2013-09-04 |
2023-08-12 |
Not clear |
| J T Lynch, T D D Somerville, G J Spencer, X Huang, T C P Somervaill. TTC5 is required to prevent apoptosis of acute myeloid leukemia stem cells. Cell death & disease. vol 4. 2013-08-23. PMID:23559008. |
consistent with the physical interaction of ttc5 and ep300, the onset of apoptosis following kd of either gene was preceded by reduced expression of bcl2 and increased expression of pro-apoptotic genes. |
2013-08-23 |
2023-08-12 |
human |
| J T Lynch, T D D Somerville, G J Spencer, X Huang, T C P Somervaill. TTC5 is required to prevent apoptosis of acute myeloid leukemia stem cells. Cell death & disease. vol 4. 2013-08-23. PMID:23559008. |
forced expression of bcl2 blocked apoptosis and partially rescued the clonogenic potential of aml cells following ttc5 kd. |
2013-08-23 |
2023-08-12 |
human |