| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elżbieta Płuciennik, Katarzyna Kośla, Katarzyna Wójcik-Krowiranda, Andrzej Bieńkiewicz, Andrzej K Bednare. The WWOX tumor suppressor gene in endometrial adenocarcinoma. International journal of molecular medicine. vol 32. issue 6. 2014-05-27. PMID:24126431. |
quantitative pcr was used to assess the correlation between the expression levels of wwox and the genes involved in the proliferation (mki67), apoptosis (bax, bcl2), signal transduction (egfr), cell cycle (ccne1, ccnd1), cell adhesion (cdh1) and transcription regulation (tp73, ncor1). |
2014-05-27 |
2023-08-12 |
Not clear |
| K Kurokawa, Y Akaike, K Masuda, Y Kuwano, K Nishida, N Yamagishi, K Kajita, T Tanahashi, K Rokuta. Downregulation of serine/arginine-rich splicing factor 3 induces G1 cell cycle arrest and apoptosis in colon cancer cells. Oncogene. vol 33. issue 11. 2014-05-15. PMID:23503458. |
the knockdown also induced apoptosis in association with reduction of bcl2 protein levels. |
2014-05-15 |
2023-08-12 |
Not clear |
| Miki Kiyota, Junya Kuroda, Mio Yamamoto-Sugitani, Yuji Shimura, Ryuko Nakayama, Hisao Nagoshi, Shinsuke Mizutani, Yoshiaki Chinen, Nana Sasaki, Natsumi Sakamoto, Tsutomu Kobayashi, Yosuke Matsumoto, Shigeo Horiike, Masafumi Taniwak. FTY720 induces apoptosis of chronic myelogenous leukemia cells via dual activation of BIM and BID and overcomes various types of resistance to tyrosine kinase inhibitors. Apoptosis : an international journal on programmed cell death. vol 18. issue 11. 2014-05-08. PMID:23851982. |
enforced expression of either bcl2 or the dominant-negative protein of fadd (fadd.dn) partly protected cml cells from apoptosis by fty720, indicating the involvement of both cell extrinsic and intrinsic apoptosis pathways. |
2014-05-08 |
2023-08-12 |
Not clear |
| Miki Kiyota, Junya Kuroda, Mio Yamamoto-Sugitani, Yuji Shimura, Ryuko Nakayama, Hisao Nagoshi, Shinsuke Mizutani, Yoshiaki Chinen, Nana Sasaki, Natsumi Sakamoto, Tsutomu Kobayashi, Yosuke Matsumoto, Shigeo Horiike, Masafumi Taniwak. FTY720 induces apoptosis of chronic myelogenous leukemia cells via dual activation of BIM and BID and overcomes various types of resistance to tyrosine kinase inhibitors. Apoptosis : an international journal on programmed cell death. vol 18. issue 11. 2014-05-08. PMID:23851982. |
gene knockdown of either bim or bid partly protected k562 cells from apoptosis by fty720, but the extent of cell protection was not as much as that by overexpression of either bcl2 or fadd.dn. |
2014-05-08 |
2023-08-12 |
Not clear |
| James Q Wang, Yogesh S Jeelall, Bruce Beutler, Keisuke Horikawa, Christopher C Goodno. Consequences of the recurrent MYD88(L265P) somatic mutation for B cell tolerance. The Journal of experimental medicine. vol 211. issue 3. 2014-05-07. PMID:24534189. |
myd88(l265p) caused self-reactive b cells to accumulate in vivo only when apoptosis was opposed by bcl2 overexpression. |
2014-05-07 |
2023-08-12 |
Not clear |
| Tian-Quan Yang, Xiao-Jun Lu, Ting-Feng Wu, Da-Dong Ding, Zhao-Hui Zhao, Gui-Lin Chen, Xue-Shun Xie, Bin Li, Yong-Xin Wei, Ling-Chuan Guo, Yu Zhang, Yu-Lun Huang, You-Xin Zhou, Zi-Wei D. MicroRNA-16 inhibits glioma cell growth and invasion through suppression of BCL2 and the nuclear factor-κB1/MMP9 signaling pathway. Cancer science. vol 105. issue 3. 2014-05-06. PMID:24418124. |
our results also indicated that upregulation of mir-16 promoted apoptosis by suppressing bcl2 expression. |
2014-05-06 |
2023-08-12 |
mouse |
| M Scherr, A Elder, K Battmer, D Barzan, S Bomken, M Ricke-Hoch, A Schröder, L Venturini, H J Blair, J Vormoor, O Ottmann, A Ganser, A Pich, D Hilfiker-Kleiner, O Heidenreich, M Ede. Differential expression of miR-17~92 identifies BCL2 as a therapeutic target in BCR-ABL-positive B-lineage acute lymphoblastic leukemia. Leukemia. vol 28. issue 3. 2014-04-30. PMID:24280866. |
we validated bcl2 as a direct target of this mirna cluster in mice and humans, and, similar to mir-17~19b overexpression, bcl2-specific rnai strongly induced apoptosis in bcr-abl-positive cells. |
2014-04-30 |
2023-08-12 |
mouse |
| M Scherr, A Elder, K Battmer, D Barzan, S Bomken, M Ricke-Hoch, A Schröder, L Venturini, H J Blair, J Vormoor, O Ottmann, A Ganser, A Pich, D Hilfiker-Kleiner, O Heidenreich, M Ede. Differential expression of miR-17~92 identifies BCL2 as a therapeutic target in BCR-ABL-positive B-lineage acute lymphoblastic leukemia. Leukemia. vol 28. issue 3. 2014-04-30. PMID:24280866. |
these data demonstrate the role of mir-17~92 in regulation of apoptosis, and identify bcl2 as a therapeutic target of particular relevance in bcr-abl-positive all. |
2014-04-30 |
2023-08-12 |
mouse |
| Carlos Giovanni Silva-García, Rosa Estela Navarr. The C. elegans TIA-1/TIAR homolog TIAR-1 is required to induce germ cell apoptosis. Genesis (New York, N.Y. : 2000). vol 51. issue 10. 2014-04-25. PMID:23913578. |
we also show that tiar-1 acts downstream of ced-9 (a bcl2 homolog) to induce apoptosis under stress conditions, and apparently does not seem to regulate ced-4 or ced-3 mrnas accumulation directly. |
2014-04-25 |
2023-08-12 |
caenorhabditis_elegans |
| Anastasia Wyce, Gopinath Ganji, Kimberly N Smitheman, Chun-Wa Chung, Susan Korenchuk, Yuchen Bai, Olena Barbash, BaoChau Le, Peter D Craggs, Michael T McCabe, Karen M Kennedy-Wilson, Lydia V Sanchez, Romain L Gosmini, Nigel Parr, Charles F McHugh, Dashyant Dhanak, Rab K Prinjha, Kurt R Auger, Peter J Tummin. BET inhibition silences expression of MYCN and BCL2 and induces cytotoxicity in neuroblastoma tumor models. PloS one. vol 8. issue 8. 2014-04-16. PMID:24009722. |
gene expression analyses in neuroblastoma cell lines suggest a role of bet inhibition in apoptosis, signaling, and n-myc-driven pathways, including the direct suppression of bcl2 and mycn. |
2014-04-16 |
2023-08-12 |
mouse |
| Andrew W Taylo. Alpha-melanocyte stimulating hormone (α-MSH) is a post-caspase suppressor of apoptosis in RAW 264.7 macrophages. PloS one. vol 8. issue 8. 2014-04-16. PMID:24009773. |
since there is little know about α-msh as an anti-apoptotic factor, the effects of α-msh on caspase activity, mitochondrial membrane potential, bcl2 to bax expression, along with tunel staining, and annexin v binding were examined in raw 264.7 macrophages under serum-starved conditions that trigger apoptosis. |
2014-04-16 |
2023-08-12 |
Not clear |
| Amit Sharma, Kumar Saurabh, Sanjay Yadav, Swatantra K Jain, Devendra Parma. Expression profiling of selected genes of toxication and detoxication pathways in peripheral blood lymphocytes as a biomarker for predicting toxicity of environmental chemicals. International journal of hygiene and environmental health. vol 216. issue 6. 2014-04-08. PMID:23273579. |
these inducers were found to increase the expression of various phase ii enzymes such as glutathione s-transferases, gsts (gstm1, gsta1, gstp1 and gstk1), nqo1, ephx1 and sod1, genes involved in inflammation and apoptosis (p53, bcl2, apaf1 and caspase9) in both pbl and liver. |
2014-04-08 |
2023-08-12 |
rat |
| Luca A Petruccelli, Filippa Pettersson, Sonia V Del Rincón, Cynthia Guilbert, Jonathan D Licht, Wilson H Mille. Expression of leukemia-associated fusion proteins increases sensitivity to histone deacetylase inhibitor-induced DNA damage and apoptosis. Molecular cancer therapeutics. vol 12. issue 8. 2014-04-01. PMID:23536727. |
the increase in apoptosis correlated with an enhanced downregulation of the prosurvival protein bcl2. |
2014-04-01 |
2023-08-12 |
Not clear |
| b' Marko Pezdirc, Bojana \\xc5\\xbdegura, Metka Filipi\\xc4\\x8. Genotoxicity and induction of DNA damage responsive genes by food-borne heterocyclic aromatic amines in human hepatoma HepG2 cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 59. 2014-03-28. PMID:23810796.' |
however, elevated expression of bcl2 and down-regulation of bax may indicate that haas could suppress apoptosis meaning higher probability of damaged cells to survive and mutate. |
2014-03-28 |
2023-08-12 |
human |
| Adriana Aporta, Elena Catalán, Patricia Galán-Malo, Ariel Ramírez-Labrada, Marta Pérez, Gemma Azaceta, Luis Palomera, Javier Naval, Isabel Marzo, Julián Pardo, Alberto Ane. Granulysin induces apoptotic cell death and cleavage of the autophagy regulator Atg5 in human hematological tumors. Biochemical pharmacology. vol 87. issue 3. 2014-03-28. PMID:24269628. |
granulysin-induced apoptosis is prevented in jurkat cells over-expressing bcl-xl or bcl2, or lacking bak and bax or bim expression, suggesting a central role of the mitochondrial apoptotic pathway. |
2014-03-28 |
2023-08-12 |
human |
| V Jablonska-Mestanova, V Sisovsky, L Danisovic, S Polak, I Varg. The normal human newborns thymus. Bratislavske lekarske listy. vol 114. issue 7. 2014-03-21. PMID:23822626. |
we used a palette of seven monoclonal antibodies for exact localization of different cells creating the thymic microenvironment (cytokeratin ae1/ae3, desmin, actin, s100 protein, cd68, cd20, and cd45ro) as well as three monoclonal antibodies against proteins regulating the process of apoptosis (bcl2 oncoprotein, p53 protein, and survivin). |
2014-03-21 |
2023-08-12 |
human |
| Jiapeng Wang, Zhaomin Li, Yongzheng He, Feng Pan, Shi Chen, Steven Rhodes, Lihn Nguyen, Jin Yuan, Li Jiang, Xianlin Yang, Ophelia Weeks, Ziyue Liu, Jiehao Zhou, Hongyu Ni, Chen-Leng Cai, Mingjiang Xu, Feng-Chun Yan. Loss of Asxl1 leads to myelodysplastic syndrome-like disease in mice. Blood. vol 123. issue 4. 2014-03-19. PMID:24255920. |
furthermore, asxl1(-/-) lin(-)c-kit(+) cells exhibited decreased global levels of h3k27me3 and h3k4me3 and altered expression of genes regulating apoptosis (bcl2, bcl2l12, bcl2l13). |
2014-03-19 |
2023-08-12 |
mouse |
| Toru Okamoto, Leigh Coultas, Donald Metcalf, Mark F van Delft, Stefan P Glaser, Megumi Takiguchi, Andreas Strasser, Philippe Bouillet, Jerry M Adams, David C S Huan. Enhanced stability of Mcl1, a prosurvival Bcl2 relative, blunts stress-induced apoptosis, causes male sterility, and promotes tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 1. 2014-03-12. PMID:24363325. |
enhanced stability of mcl1, a prosurvival bcl2 relative, blunts stress-induced apoptosis, causes male sterility, and promotes tumorigenesis. |
2014-03-12 |
2023-08-12 |
mouse |
| Szymon Stoma, Alexandre Donzé, François Bertaux, Oded Maler, Gregory Bat. STL-based analysis of TRAIL-induced apoptosis challenges the notion of type I/type II cell line classification. PLoS computational biology. vol 9. issue 5. 2014-03-11. PMID:23675292. |
cells show distinct behaviors on several aspects of apoptosis, including (i) the relative order of caspases activation, (ii) the necessity of mitochondria outer membrane permeabilization (momp) for effector caspase activation, and (iii) the survival of cell lines overexpressing bcl2. |
2014-03-11 |
2023-08-12 |
Not clear |
| N I Grineva, T V Akhlynina, A M Timofeev, L P Gerasimova, D A Shmarov, N M Naĭdenova, T E Manakova, T G Sarycheva, L G Kovalev. [Apoptosis and neutrophils on the regulation of proliferation and differentiation ex vifo of myeloid cells with Ph-chromosome]. Molekuliarnaia biologiia. vol 47. issue 4. 2014-03-11. PMID:24466754. |
human myeloid cells with ph chromosome (ph+ cells) from chronic myeloid leukemia (cml) in the course of proliferation and differentiation ex vivo are regulated under alternation of cell proliferation and neutrophil maturation stages by consecutive blocking and inducing apoptosis with of neutrophils participation as well bcr/abl, bax and bcl2 genes expression. |
2014-03-11 |
2023-08-12 |
human |