| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chonglin Luo, Paul W Tetteh, Patrick R Merz, Elke Dickes, Alia Abukiwan, Agnes Hotz-Wagenblatt, Stefan Holland-Cunz, Tobias Sinnberg, Birgit Schittek, Dirk Schadendorf, Sven Diederichs, Stefan B Eichmülle. miR-137 inhibits the invasion of melanoma cells through downregulation of multiple oncogenic target genes. The Journal of investigative dermatology. vol 133. issue 3. 2013-06-20. PMID:23151846. |
finally, mir-137 induced apoptosis in melanoma cell lines and decreased bcl2 levels. |
2013-06-20 |
2023-08-12 |
Not clear |
| Sharyn Tauro, Phuong Nguyen, Bofeng Li, Terrence L Geige. Diversification and senescence of Foxp3+ regulatory T cells during experimental autoimmune encephalomyelitis. European journal of immunology. vol 43. issue 5. 2013-06-17. PMID:23436224. |
this was associated with diminished bcl2 and increased apoptosis of isolated cells. |
2013-06-17 |
2023-08-12 |
Not clear |
| Patrick B Walter, John Porter, Patricia Evans, Janet L Kwiatkowski, Ellis J Neufeld, Thomas Coates, Patricia J Giardina, Robert W Grady, Elliott Vichinsky, Nancy Olivieri, Felicia Trachtenberg, Daniele Alberti, Ellen Fung, Bruce Ames, Annie Higa, Paul Harmat. Increased leucocyte apoptosis in transfused β-thalassaemia patients. British journal of haematology. vol 160. issue 3. 2013-06-14. PMID:23216540. |
previously, we showed that over the treatment year, hepatic iron declined; we now show that the ratio of bax/bcl-2 (bcl2), (-27·3%/year), and caspase-9 activity (-13·3%/year) declined in both treatment groups, suggesting that chelation decreases body iron and indicators of pbl apoptosis. |
2013-06-14 |
2023-08-12 |
human |
| Anil K G Kadegowda, M Jawad Khan, Liliana S Piperova, Beverly B Teter, Sandra L Rodriguez-Zas, Richard A Erdman, Juan J Loo. Trans-10, cis 12-Conjugated Linoleic Acid-Induced Milk Fat Depression Is Associated with Inhibition of PPARγ Signaling and Inflammation in Murine Mammary Tissue. Journal of lipids. vol 2013. 2013-06-14. PMID:23762566. |
dietary cla induced genes related to er stress (xbp1), apoptosis (bcl2), and inflammation (orm1, saa2, and cp). |
2013-06-14 |
2023-08-12 |
mouse |
| R Gallo, M Natale, F Vendrame, U Boggi, F Filipponi, P Marchetti, F Laghi Pasini, F Dott. In vitro effects of mycophenolic acid on survival, function, and gene expression of pancreatic beta-cells. Acta diabetologica. vol 49 Suppl 1. 2013-06-13. PMID:22249339. |
consequently, we evaluated the viability, the induction of apoptosis, the glucose-stimulated insulin secretion, and the expression of β-cell function genes (isl1, pax6, glut-2, glucokinase) and apoptosis-related genes (bax and bcl2). |
2013-06-13 |
2023-08-12 |
mouse |
| Huan Wang, Yue-Bo Yang, Hui-Min Shen, Jian Gu, Tian Li, Xiao-Mao L. ABT-737 induces Bim expression via JNK signaling pathway and its effect on the radiation sensitivity of HeLa cells. PloS one. vol 7. issue 12. 2013-06-11. PMID:23285061. |
abt-737 is a bh3 mimetic small molecule inhibitor that can effectively inhibit the activity of antiapoptotic bcl-2 family proteins including bcl2, bcl-xl and bcl-w, and further enhances the effect of apoptosis by activating the proapoptotic proteins (t-bid, bad, bim). |
2013-06-11 |
2023-08-12 |
Not clear |
| Ping Ye, Liang Zhao, Thomas J Gond. The MYB oncogene can suppress apoptosis in acute myeloid leukemia cells by transcriptional repression of DRAK2 expression. Leukemia research. vol 37. issue 5. 2013-06-07. PMID:23398943. |
rna interference-mediated suppression of myb expression promoted apoptosis in the aml cell line u937, without affecting expression of the anti-apoptotic myb target bcl2. |
2013-06-07 |
2023-08-12 |
Not clear |
| Nicole A Doudican, Sara A Byron, Pamela M Pollock, Seth J Orlo. XIAP downregulation accompanies mebendazole growth inhibition in melanoma xenografts. Anti-cancer drugs. vol 24. issue 2. 2013-05-23. PMID:23059386. |
mebendazole (mbz) was identified as a promising therapeutic on the basis of its ability to induce apoptosis in melanoma cell lines through a b-cell lymphoma 2 (bcl2)-dependent mechanism. |
2013-05-23 |
2023-08-12 |
human |
| Nicole A Doudican, Sara A Byron, Pamela M Pollock, Seth J Orlo. XIAP downregulation accompanies mebendazole growth inhibition in melanoma xenografts. Anti-cancer drugs. vol 24. issue 2. 2013-05-23. PMID:23059386. |
inhibition of melanoma growth in vivo is accompanied by phosphorylation of bcl2 and decreased levels of x-linked inhibitor of apoptosis (xiap). |
2013-05-23 |
2023-08-12 |
human |
| Jayant S Londhe, Thomas P A Devasagayam, L Yeap Foo, Padma Shastry, Saroj S Ghaskadb. Geraniin and amariin, ellagitannins from Phyllanthus amarus, protect liver cells against ethanol induced cytotoxicity. Fitoterapia. vol 83. issue 8. 2013-05-22. PMID:22982332. |
poly (adp-ribose) polymerase (parp), bax and bcl2 were checked to assess the induction of apoptosis using western blots. |
2013-05-22 |
2023-08-12 |
mouse |
| Paramasivan Poornima, Robin Sheeba Quency, Viswandha Vijaya Padm. Neferine induces reactive oxygen species mediated intrinsic pathway of apoptosis in HepG2 cells. Food chemistry. vol 136. issue 2. 2013-05-21. PMID:23122111. |
our data further indicate reduction of Δψm and increased [ca(2+)](i) during apoptosis induction by neferine with increased expression of apoptotic proteins such as bax, bad, cleaved forms of caspase 3, caspase 9 and parp, with the downregulation of anti-apoptotic protein bcl2 in hepg2 cells. |
2013-05-21 |
2023-08-12 |
Not clear |
| Chia-Hua Chou, Ching-Chih Lin, Ming-Chang Yang, Chih-Chang Wei, Huei-De Liao, Run-Chin Lin, Wen-Yu Tu, Tsung-Chieh Kao, Ching-Mei Hsu, Jiin-Tsuey Cheng, An-Kuo Chou, Chu-I Lee, Joon-Khim Loh, Shen-Long Howng, Yi-Ren Hon. GSK3beta-mediated Drp1 phosphorylation induced elongated mitochondrial morphology against oxidative stress. PloS one. vol 7. issue 11. 2013-05-14. PMID:23185298. |
in investigating the biofunctionality of phosphorylation sites within the ged domain, cells overexpressing drp1 s693d and s637d, but not s693a, showed an acquired resistance to h(2)o(2)-induced mitochondrial fragmentation and ensuing apoptosis, which affected cytochrome c, capase-3, -7, and parp, but not lc3b, atg-5, beclin-1 and bcl2 expressions. |
2013-05-14 |
2023-08-12 |
Not clear |
| Jake Shortt, Ricky W Johnston. Oncogenes in cell survival and cell death. Cold Spring Harbor perspectives in biology. vol 4. issue 12. 2013-05-13. PMID:23209150. |
therefore, cooperating genetic or epigenetic effects to suppress apoptosis (e.g., overexpression of bcl2) are required to enable the dual transforming processes of unbridled cell proliferation and robust suppression of apoptosis. |
2013-05-13 |
2023-08-12 |
Not clear |
| Elżbieta Płuciennik, Magdalena Nowakowska, Wioletta I Wujcicka, Anna Sitkiewicz, Bernarda Kazanowska, Elżbieta Zielińska, Andrzej K Bednare. Genetic alterations of WWOX in Wilms' tumor are involved in its carcinogenesis. Oncology reports. vol 28. issue 4. 2013-05-09. PMID:22842668. |
we evaluated the correlation between expression of wwox and genes involved in proliferation (ki67), apoptosis (bcl2, bax), signal transduction (erbb4, erbb2, egfr), cell cycle (ccne1, ccnd1), cell adhesion (cdh1) and transcription (tp73) using real-time rt-pcr in 23 tumor samples. |
2013-05-09 |
2023-08-12 |
Not clear |
| Xiaojia Guo, John C Schmitz, Barton C Kenney, Edward M Uchio, Sanjay Kulkarni, Charles H Ch. Intermedin is overexpressed in hepatocellular carcinoma and regulates cell proliferation and survival. Cancer science. vol 103. issue 8. 2013-05-07. PMID:22625651. |
blockage of imd signaling using either an antagonist peptide or a neutralizing antibody inhibited growth in a dose-dependent manner with concomitant induction of apoptosis, causing cleavage of caspase-8 and downregulation of gli1 and bcl2. |
2013-05-07 |
2023-08-12 |
human |
| Qing Li, Gang Wang, Jie Zhang, Ping Zhou, Tian-Yang Wang, Wei Cui, Ming-Jiu Luo, Jing-He Ta. Combined inhibitory effects of pyruvate and low temperature on postovulatory aging of mouse oocytes. Biology of reproduction. vol 87. issue 5. 2013-04-22. PMID:22954795. |
oocytes with impaired developmental potential after culture at 15°c for 96 h and at 5°c for 48 h showed unrecoverable decreases in the content of glutathione, the glutathione/oxidized glutathione ratio, the bcl2 content, and in the numbers of oocytes with normal spindles and cortical granule distribution, suggesting induction of oxidative stress, which caused oocyte apoptosis and cytoskeleton alterations by downregulating bcl2. |
2013-04-22 |
2023-08-12 |
mouse |
| Serkan Durdu, Gunseli C Deniz, Deniz Balci, Cagin Zaim, Arin Dogan, Alp Can, Kamil C Akcali, Ahmet Ruchan Aka. Apoptotic vascular smooth muscle cell depletion via BCL2 family of proteins in human ascending aortic aneurysm and dissection. Cardiovascular therapeutics. vol 30. issue 6. 2013-04-22. PMID:22978789. |
this study investigates the expression patterns of bcl2 (b-cell cll/lymphoma2) family of proteins and the extent of vascular smooth muscle cell (vsmc) apoptosis in thoracic aortic aneurysms (taa), type-a aortic dissections (tad), and nondilated ascending aortic samples. |
2013-04-22 |
2023-08-12 |
human |
| Sankaranarayanan Kannan, Robert M Sutphin, Mandy G Hall, Leonard S Golfman, Wendy Fang, Riitta M Nolo, Lauren J Akers, Richard A Hammitt, John S McMurray, Steven M Kornblau, Ari M Melnick, Maria E Figueroa, Patrick A Zweidler-McKa. Notch activation inhibits AML growth and survival: a potential therapeutic approach. The Journal of experimental medicine. vol 210. issue 2. 2013-04-12. PMID:23359069. |
induced activation through any of the notch receptors (notch1-4), or through the notch target hairy/enhancer of split 1 (hes1), consistently leads to aml growth arrest and caspase-dependent apoptosis, which are associated with b cell lymphoma 2 (bcl2) loss and enhanced p53/p21 expression. |
2013-04-12 |
2023-08-12 |
human |
| Feiran Gong, Luan Sun, Yujie Su. A novel SATB1 binding site in the BCL2 promoter region possesses transcriptional regulatory function. Journal of biomedical research. vol 24. issue 6. 2013-04-05. PMID:23554662. |
bcl2 is a key regulator of apoptosis. |
2013-04-05 |
2023-08-12 |
Not clear |
| Chun-Yan Sun, Xiao-Mei She, You Qin, Zhang-Bo Chu, Lei Chen, Li-Sha Ai, Lu Zhang, Yu H. miR-15a and miR-16 affect the angiogenesis of multiple myeloma by targeting VEGF. Carcinogenesis. vol 34. issue 2. 2013-04-03. PMID:23104180. |
two mirnas, mir-15a and mir-16, which act as putative tumor suppressor by targeting the oncogene bcl2, have been implicated in cell cycle, apoptosis and proliferation. |
2013-04-03 |
2023-08-12 |
mouse |