| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Berlinda Verdoodt, Matthias Neid, Markus Vogt, Viktoria Kuhn, Sven-Thorsten Liffers, Rein-Jüri Palisaar, Joachim Noldus, Andrea Tannapfel, Alireza Mirmohammadsadeg. MicroRNA-205, a novel regulator of the anti-apoptotic protein Bcl2, is downregulated in prostate cancer. International journal of oncology. vol 43. issue 1. 2014-01-07. PMID:23612742. |
consistent with its anti-apoptotic target bcl2, mir-205 promoted apoptosis in prostate cancer cells in response to dna damage by cisplatin and doxorubicin in the prostate cancer cell lines pc3 and lncap. |
2014-01-07 |
2023-08-12 |
Not clear |
| Doreen Kunze, Kai Kraemer, Kati Erdmann, Michael Froehner, Manfred P Wirth, Susanne Fuesse. Simultaneous siRNA-mediated knockdown of antiapoptotic BCL2, Bcl-xL, XIAP and survivin in bladder cancer cells. International journal of oncology. vol 41. issue 4. 2013-12-31. PMID:22797576. |
in ej28 cells, combined knockdown of bcl2, bcl-xl, xiap and survivin caused a 2.5-fold enhancement in apoptosis rate and reduced cellular viability by 40%. |
2013-12-31 |
2023-08-12 |
Not clear |
| C Cameron Yin, Rajyalakshmi Luthr. Molecular detection of t(14;18)(q32;q21) in follicular lymphoma. Methods in molecular biology (Clifton, N.J.). vol 999. 2013-12-31. PMID:23666699. |
this translocation juxtaposes the bcl2 oncogene at 18q21 with the igh@ at 14q32, and leads to overexpression of bcl2 protein which protects the cells from apoptosis. |
2013-12-31 |
2023-08-12 |
Not clear |
| Anjana Kalita, Sakshi Gupta, Preeti Singh, Avadhesha Surolia, Kakoli Banerje. IGF-1 stimulated upregulation of cyclin D1 is mediated via STAT5 signaling pathway in neuronal cells. IUBMB life. vol 65. issue 5. 2013-12-23. PMID:23504816. |
signal transducer and activator of transcription (stats) regulate various target genes such as cyclin d1, myc, and bcl2 in nonneuronal cells which contribute towards progression as well as prevention of apoptosis and are involved in differentiation and cell survival. |
2013-12-23 |
2023-08-12 |
Not clear |
| Marcela Fuentes, Mónica Andrews, Miguel Arredondo-Olguí. Effects of high iron and glucose concentrations over the relative expression of Bcl2, Bax, and Mfn2 in MIN6 cells. Biological trace element research. vol 153. issue 1-3. 2013-12-16. PMID:23605050. |
hyperglycemia is linked to mitochondrial dysfunction and reduced β-cell mass due to the reduced expression of genes such as mfn2 as well as the participation of the bcl2 gene family, responsible for increased apoptosis. |
2013-12-16 |
2023-08-12 |
Not clear |
| Quanxin Gao, Lili Qi, Tianxing Wu, Jinbo Wan. Ability of Clostridium butyricum to inhibit Escherichia coli-induced apoptosis in chicken embryo intestinal cells. Veterinary microbiology. vol 160. issue 3-4. 2013-12-13. PMID:22771207. |
c. butyricum also showed a significant inhibitory effect on ehec-induced apoptosis by modulating the expression of xiap (x-linked inhibitor of apoptosis protein), bclxl (b-cell lymphoma-extra large), fas, bcl2 (b-cell leukemia/lymphoma-2), bax (bcl-2-associated x protein), p53 (tumor protein 53) and via inhibition of caspase-9 and caspase-3 activation. |
2013-12-13 |
2023-08-12 |
chicken |
| Utthara Nayar, Pin Lu, Rebecca L Goldstein, Jelena Vider, Gianna Ballon, Anna Rodina, Tony Taldone, Hediye Erdjument-Bromage, Max Chomet, Ronald Blasberg, Ari Melnick, Leandro Cerchietti, Gabriela Chiosis, Y Lynn Wang, Ethel Cesarma. Targeting the Hsp90-associated viral oncoproteome in gammaherpesvirus-associated malignancies. Blood. vol 122. issue 16. 2013-12-12. PMID:23943653. |
analysis of the interactome revealed apoptosis as a central pathway; therefore, we tested a bcl2 family inhibitor in primary effusion lymphoma cells. |
2013-12-12 |
2023-08-12 |
mouse |
| Jan Petrasek, Arvin Iracheta-Vellve, Timea Csak, Abhishek Satishchandran, Karen Kodys, Evelyn A Kurt-Jones, Katherine A Fitzgerald, Gyongyi Szab. STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 41. 2013-12-04. PMID:24052526. |
activated irf3 associated with the proapoptotic molecule bax [b-cell lymphoma 2 (bcl2)-associated x protein] and contributed to hepatocyte apoptosis. |
2013-12-04 |
2023-08-12 |
Not clear |
| F Salm, P Cwiek, A Ghosal, A Lucia Buccarello, F Largey, C Wotzkow, K Höland, B Styp-Rekowska, V Djonov, I Zlobec, N Bodmer, N Gross, F Westermann, S C Schäfer, A Arcar. RNA interference screening identifies a novel role for autocrine fibroblast growth factor signaling in neuroblastoma chemoresistance. Oncogene. vol 32. issue 34. 2013-11-26. PMID:23027129. |
silencing of fgfr2 sensitized nb cells to cisplatin-induced apoptosis, which was regulated by the downregulation of the anti-apoptotic proteins bcl2 and bclxl. |
2013-11-26 |
2023-08-12 |
Not clear |
| Vikas V Dukhande, Ivana Kawikova, Alfred L M Bothwell, James C K La. Neuroprotection against neuroblastoma cell death induced by depletion of mitochondrial glutathione. Apoptosis : an international journal on programmed cell death. vol 18. issue 6. 2013-11-26. PMID:23494481. |
prevention of apoptosis by bcl2 overexpression or use of antioxidant ebselen did not confer neuroprotection. |
2013-11-26 |
2023-08-12 |
human |
| Feng Yao, Qingqi Han, Chenxi Zhong, Heng Zha. TRAF6 promoted the tumorigenicity of esophageal squamous cell carcinoma. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 34. issue 5. 2013-11-26. PMID:23794111. |
mechanistically, traf6 inhibited cell apoptosis by downregulation of activated caspase 3 and cleaved poly adp ribose polymerase and upregulation of c-jun, bcl2, and c-myc. |
2013-11-26 |
2023-08-12 |
Not clear |
| Meike Vogler, David Dinsdale, Martin J S Dyer, Gerald M Cohe. ABT-199 selectively inhibits BCL2 but not BCL2L1 and efficiently induces apoptosis of chronic lymphocytic leukaemic cells but not platelets. British journal of haematology. vol 163. issue 1. 2013-11-26. PMID:23826785. |
abt-199 selectively inhibits bcl2 but not bcl2l1 and efficiently induces apoptosis of chronic lymphocytic leukaemic cells but not platelets. |
2013-11-26 |
2023-08-12 |
Not clear |
| Hong Liu, Su Mi, Zhe Li, Fang Hua, Zhuo-Wei H. Interleukin 17A inhibits autophagy through activation of PIK3CA to interrupt the GSK3B-mediated degradation of BCL2 in lung epithelial cells. Autophagy. vol 9. issue 5. 2013-11-22. PMID:23514933. |
here we report that the phosphorylation of b-cell cll/lymphoma 2 (bcl2), an apoptosis regulatory protein, was inhibited in the presence of il17a in lung epithelial cells, and this reduction suppressed the ubiquitination degradation of bcl2, which subsequently attenuated autophagy by promoting the interaction of bcl2 and becn1. |
2013-11-22 |
2023-08-12 |
Not clear |
| S V Mehta, S N Shukla, H H Vor. Overexpression of Bcl2 protein predicts chemoresistance in acute myeloid leukemia: its correlation with FLT3. Neoplasma. vol 60. issue 6. 2013-11-14. PMID:23906301. |
deregulation of apoptosis is one of the important features of aml and to understand the molecular mechanism underlying apoptosis and its contribution to tumor progression, this study aimed to evaluate anti-apoptotic bcl2 protein expression in aml and correlate with flt3 parameters for their role in prognosis of disease.bcl2 and flt3 protein expression was quantified by flow cytometry on leukemic blasts in total 174 de novo aml, myelodysplastic syndrome (mds) and aplastic anemia patients. |
2013-11-14 |
2023-08-12 |
Not clear |
| Ying Wang, Shao-Lin Xu, Ya-Zhen Wu, Mei-Sheng Zhao, Wen-Jing Xu, Hai-Yan Yang, Yu-Xin L. Simvastatin induces caspase-dependent apoptosis and activates P53 in OCM-1 cells. Experimental eye research. vol 113. 2013-11-07. PMID:23727160. |
in addition, simvastatin resulted in an increase in levels of reactive oxygen species (ros) in ocm-1 cells and simvastatin significantly triggered apoptosis in ocm-1 cells, which was characterized by increased chromatin condensation, activation of caspase-9 and cleaved-caspase-3, increased expression mitochondrion-related apoptosis protein of p53, bax and decreased expression of bcl2 and iaspp. |
2013-11-07 |
2023-08-12 |
Not clear |
| Wei Wang, Fang Gu, Cai Wei, Yigui Tang, Xin Zheng, Mingqiang Ren, Yide Qi. PGPIPN, a therapeutic hexapeptide, suppressed human ovarian cancer growth by targeting BCL2. PloS one. vol 8. issue 4. 2013-11-05. PMID:23593287. |
further study demonstrated that the anti-tumor effect of pgpipn is partially through promoting cell apoptosis by inhibiting bcl2 pathway. |
2013-11-05 |
2023-08-12 |
mouse |
| Prevost Bi-Koffi Kouamé, Camille Jacques, Gustave Bedi, Virginie Silvestre, Denis Loquet, Sophie Barillé-Nion, Richard J Robins, Illa Te. Phytochemicals isolated from leaves of Chromolaena odorata: impact on viability and clonogenicity of cancer cell lines. Phytotherapy research : PTR. vol 27. issue 6. 2013-10-24. PMID:22899281. |
2'-hydroxy-4,4',5',6'-tetramethoxychalcone was found to be both cytotoxic and anticlonogenic at 20 µm in cell lines cal51, mcf7 and mdamb-468, and to act synergistically with the bcl2 inhibitor abt737 to enhance apoptosis in cal51 breast cancer cells. |
2013-10-24 |
2023-08-12 |
Not clear |
| Chengmeng Jin, Wei Yu, Xiaoyan Lou, Fan Zhou, Xu Han, Na Zhao, Biaoyang Li. UCHL1 Is a Putative Tumor Suppressor in Ovarian Cancer Cells and Contributes to Cisplatin Resistance. Journal of Cancer. vol 4. issue 8. 2013-10-24. PMID:24155778. |
several apoptosis related genes were increased after uchl1 knockdown, including apoptosis regulator bcl2, bcl11a, aen and xiap. |
2013-10-24 |
2023-08-12 |
Not clear |
| Jessica L Schwartz-Roberts, Ayesha N Shajahan, Katherine L Cook, Anni Wärri, Mones Abu-Asab, Robert Clark. GX15-070 (obatoclax) induces apoptosis and inhibits cathepsin D- and L-mediated autophagosomal lysis in antiestrogen-resistant breast cancer cells. Molecular cancer therapeutics. vol 12. issue 4. 2013-10-22. PMID:23395885. |
thus, gx15-070 has dual roles in promoting cell death: (i) directly inhibiting antiapoptotic bcl2 family members, thereby inducing apoptosis; and (ii) inhibiting downstream ctsd and ctsl1 protein expression to limit the ability of cells to use degraded material to fuel cellular metabolism and restore homeostasis. |
2013-10-22 |
2023-08-12 |
Not clear |
| Zheng Li, Hui-Ying Qiu, Yang Jiao, Jian-Nong Cen, Chun-Mei Fu, Shao-Yan Hu, Ming-Qing Zhu, De-Pei Wu, Xiao-Fei Q. Growth and differentiation effects of Homer3 on a leukemia cell line. Asian Pacific journal of cancer prevention : APJCP. vol 14. issue 4. 2013-10-22. PMID:23725168. |
forced expression of homer3 in transfected k562 cells inhibited proliferation, influenced the cell cycle profile, affected apoptosis induced by as2o3 through inhibition of bcl2 expression, and also promoted cell differentiation induced by 12-o-tetra decanoylphorbol-acetate (tpa). |
2013-10-22 |
2023-08-12 |
Not clear |