| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| O Csuka, E Remenár, K Koronczay, Z Doleschall, G Német. Predictive value of p53, Bcl2 and bax in the radiotherapy of head and neck cancer. Pathology oncology research : POR. vol 3. issue 3. 2012-10-02. PMID:18470731. |
overexpression of bcl2, however, inhibits apoptosis via hetero- and homodimeric interaction. |
2012-10-02 |
2023-08-12 |
Not clear |
| P Massari, L M Wetzle. Studies on the effect of neisserial porins on apoptosis of Mammalian cells. Methods in molecular medicine. vol 67. 2012-10-02. PMID:21337167. |
viral products have been shown to inhibit apoptosis by mimicking anti-apoptotic related proteins (e.g., bcl2, flips, etc.) |
2012-10-02 |
2023-08-12 |
Not clear |
| Ajay Kumar, Shiva Kant, Sukh Mahendra Sing. Novel molecular mechanisms of antitumor action of dichloroacetate against T cell lymphoma: Implication of altered glucose metabolism, pH homeostasis and cell survival regulation. Chemico-biological interactions. vol 199. issue 1. 2012-09-28. PMID:22705712. |
moreover, we also observed an alteration in the expression of other apoptosis and cell survival regulatory molecules: puma, glut1, bcl2, p53, cad, caspase-3 and hsp70. |
2012-09-28 |
2023-08-12 |
Not clear |
| Ismail Kaddour-Djebbar, Vivek Choudhary, Vijayabaskar Lakshmikanthan, Robert Shirley, Manal El Gaish, Mohamed Al-Shabrawey, Belal Al-Husein, Roger Zhong, Michael Davis, Zheng Dong, Wendy B Bollag, M Vijay Kuma. Diltiazem enhances the apoptotic effects of proteasome inhibitors to induce prostate cancer cell death. The Journal of pharmacology and experimental therapeutics. vol 341. issue 3. 2012-09-24. PMID:22393247. |
the combination of diltiazem and lactacystin also up-regulated the levels of bik and released bak from bcl-xl, indicating the involvement of the bcl2 family pathway in this apoptosis. |
2012-09-24 |
2023-08-12 |
Not clear |
| Kwang Hwa Jung, Ji Heon Noh, Jeong Kyu Kim, Jung Woo Eun, Hyun Jin Bae, Hong Jian Xie, Young Gyoon Chang, Min Gyu Kim, Hanna Park, Jung Young Lee, Suk Woo Na. HDAC2 overexpression confers oncogenic potential to human lung cancer cells by deregulating expression of apoptosis and cell cycle proteins. Journal of cellular biochemistry. vol 113. issue 6. 2012-09-21. PMID:22492270. |
hdac2 inactivation resulted in regression of tumor cell growth and activation of cellular apoptosis via p53 and bax activation and bcl2 suppression. |
2012-09-21 |
2023-08-12 |
mouse |
| Yiping Huang, Alice Y Chuang, Edward A Ratovitsk. Phospho-ΔNp63α/miR-885-3p axis in tumor cell life and cell death upon cisplatin exposure. Cell cycle (Georgetown, Tex.). vol 10. issue 22. 2012-09-17. PMID:22071691. |
finally, mir-885-3p modulated the cisplatin-induced tp53-dependent mitochondrial apoptosis by up regulation of mdm4 levels and down regulation of bcl2 levels in mitochondria. |
2012-09-17 |
2023-08-12 |
Not clear |
| Zhangjian Huang, Junjie Fu, Ling Liu, Yijun Sun, Yisheng Lai, Hui Ji, Edward E Knaus, Jide Tian, Yihua Zhan. Glycosylated diazeniumdiolate-based oleanolic acid derivatives: synthesis, in vitro and in vivo biological evaluation as anti-human hepatocellular carcinoma agents. Organic & biomolecular chemistry. vol 10. issue 19. 2012-09-07. PMID:22473516. |
furthermore, 6 induced hcc cell apoptosis, which was accompanied by lower mitochondrial membrane potentials and bcl2 expression, but with higher cytochrome c release, bax, caspase 3 and 9 expression activities in hcc cells. |
2012-09-07 |
2023-08-12 |
mouse |
| Brahmasani Sambasiva Rao, Yelisetti Uma Mahesh, Katari Venu Charan, Komjeti Suman, Nithya Sekhar, Sisinthy Shivaj. Effect of vitrification on meiotic maturation and expression of genes in immature goat cumulus oocyte complexes. Cryobiology. vol 64. issue 3. 2012-09-06. PMID:22280956. |
the aim of the study was to evaluate meiotic maturation, and expression of genes coding for oocyte secreted factors (gdf9, bmp15, tgfbr1, and bpr2) and apoptosis (bcl2, bax and p53) after vitrification of immature goat cumulus oocyte complexes (cocs) and in vitro maturation. |
2012-09-06 |
2023-08-12 |
Not clear |
| Leonard P Rybak, Debashree Mukherjea, Sarvesh Jajoo, Tejbeer Kaur, Vickram Ramkuma. siRNA-mediated knock-down of NOX3: therapy for hearing loss? Cellular and molecular life sciences : CMLS. vol 69. issue 14. 2012-09-04. PMID:22562580. |
in addition, sirna against nox3 reduced apoptosis as demonstrated by tunel staining, and prevented the increased expression of bax and abrogated the decrease in bcl2 expression following cisplatin administration. |
2012-09-04 |
2023-08-12 |
Not clear |
| Wei Zhu, DanXia Zhu, Shiqiang Lu, Tongshan Wang, Jian Wang, Binghua Jiang, Yongqian Shu, Ping Li. miR-497 modulates multidrug resistance of human cancer cell lines by targeting BCL2. Medical oncology (Northwood, London, England). vol 29. issue 1. 2012-08-23. PMID:21258880. |
enforced mir-497 expression reduced bcl2 protein level and sensitized sgc7901/vcr and a549/cddp cells to vcr-induced and cddp-induced apoptosis, respectively. |
2012-08-23 |
2023-08-12 |
human |
| Wei Zhu, DanXia Zhu, Shiqiang Lu, Tongshan Wang, Jian Wang, Binghua Jiang, Yongqian Shu, Ping Li. miR-497 modulates multidrug resistance of human cancer cell lines by targeting BCL2. Medical oncology (Northwood, London, England). vol 29. issue 1. 2012-08-23. PMID:21258880. |
taken together, our findings first suggested that has-mir-497 could play a role in both gastric and lung cancer cell lines at least in part by modulation of apoptosis via targeting bcl2. |
2012-08-23 |
2023-08-12 |
human |
| Nisha Bansal, Douglas C Marchion, Elona Bicaku, Yin Xiong, Ning Chen, Xiaomang B Stickles, Entidhar Al Sawah, Robert M Wenham, Sachin M Apte, Jesus Gonzalez-Bosquet, Patricia L Judson, Ardeshir Hakam, Johnathan M Lancaste. BCL2 antagonist of cell death kinases, phosphatases, and ovarian cancer sensitivity to cisplatin. Journal of gynecologic oncology. vol 23. issue 1. 2012-08-23. PMID:22355465. |
the bcl2 family proteins are critical mediators of cellular apoptosis and, as such, have been implicated as determinants of cancer cell chemo-sensitivity. |
2012-08-23 |
2023-08-12 |
Not clear |
| Arnab Banerjee, Shabana Anjum, Rachna Verma, Amitabh Krishn. Alteration in expression of estrogen receptor isoforms alpha and beta, and aromatase in the testis and its relation with changes in nitric oxide during aging in mice. Steroids. vol 77. issue 6. 2012-08-08. PMID:22366072. |
treatment with either snp or l-name on testicular steroidogenic factor (3-beta hsd/ star) or germ cell survival factor (bcl2) showed that increased no causes decreased steroidogenesis and increased germ cell apoptosis. |
2012-08-08 |
2023-08-12 |
mouse |
| Fuko Matsuda, Naoko Inoue, Noboru Manabe, Satoshi Ohkur. Follicular growth and atresia in mammalian ovaries: regulation by survival and death of granulosa cells. The Journal of reproduction and development. vol 58. issue 1. 2012-07-31. PMID:22450284. |
then, we explain about the regulation of follicular growth and atresia by granulosa cells, in which hormones, growth factors and cytokines, death ligand-receptor system and b cell lymphoma/leukemia 2 (bcl2) family members (mitochondria-mediated apoptosis) are further discussed. |
2012-07-31 |
2023-08-12 |
Not clear |
| Ayesha N Shajahan, Zachary C Dobbin, F Edward Hickman, Sivanesan Dakshanamurthy, Robert Clark. Tyrosine-phosphorylated caveolin-1 (Tyr-14) increases sensitivity to paclitaxel by inhibiting BCL2 and BCLxL proteins via c-Jun N-terminal kinase (JNK). The Journal of biological chemistry. vol 287. issue 21. 2012-07-23. PMID:22433870. |
in estrogen receptor α-positive (er(+)) breast cancer cells, phosphorylation of caveolin-1 (cav1) on tyr-14 facilitates mitochondrial apoptosis by increasing bcl2 phosphorylation in response to low dose paclitaxel (10 nm). |
2012-07-23 |
2023-08-12 |
Not clear |
| Ayesha N Shajahan, Zachary C Dobbin, F Edward Hickman, Sivanesan Dakshanamurthy, Robert Clark. Tyrosine-phosphorylated caveolin-1 (Tyr-14) increases sensitivity to paclitaxel by inhibiting BCL2 and BCLxL proteins via c-Jun N-terminal kinase (JNK). The Journal of biological chemistry. vol 287. issue 21. 2012-07-23. PMID:22433870. |
thus, we highlight novel roles for cav1 variants in cell death; wtcav1 promotes cell death, whereas cav1β promotes cell survival by preventing inactivation of bcl2 and bclxl via jnk in paclitaxel-mediated apoptosis. |
2012-07-23 |
2023-08-12 |
Not clear |
| Stefania Bruno, Cristina Grange, Federica Collino, Maria Chiara Deregibus, Vincenzo Cantaluppi, Luigi Biancone, Ciro Tetta, Giovanni Camuss. Microvesicles derived from mesenchymal stem cells enhance survival in a lethal model of acute kidney injury. PloS one. vol 7. issue 3. 2012-07-13. PMID:22431999. |
in vitro studies demonstrated that mvs up-regulated in cisplatin-treated human tubular epithelial cells anti-apoptotic genes, such as bcl-xl, bcl2 and birc8 and down-regulated genes that have a central role in the execution-phase of cell apoptosis such as casp1, casp8 and lta. |
2012-07-13 |
2023-08-12 |
mouse |
| Aurelia Busca, Mansi Saxena, Ashok Kuma. Critical role for antiapoptotic Bcl-xL and Mcl-1 in human macrophage survival and cellular IAP1/2 (cIAP1/2) in resistance to HIV-Vpr-induced apoptosis. The Journal of biological chemistry. vol 287. issue 18. 2012-07-02. PMID:22403404. |
to determine the effect of vpr on the expression of antiapoptotic proteins, we show that in contrast to the undifferentiated cells, vpr did not down-regulate the expression of antiapoptotic inhibitors of apoptosis (iaps) and bcl2 family members in macrophages, suggesting their involvement in resistance to vpr-induced apoptosis. |
2012-07-02 |
2023-08-12 |
human |
| Maria Maryanovich, Galia Oberkovitz, Hagit Niv, Lidiya Vorobiyov, Yehudit Zaltsman, Ori Brenner, Tsvee Lapidot, Steffen Jung, Atan Gros. The ATM-BID pathway regulates quiescence and survival of haematopoietic stem cells. Nature cell biology. vol 14. issue 5. 2012-06-29. PMID:22446738. |
bid, a bh3-only bcl2 family member, functions in apoptosis as well as the dna-damage response. |
2012-06-29 |
2023-08-12 |
mouse |
| Zachary L Pratt, Jingzhu Zhang, Bill Sugde. The latent membrane protein 1 (LMP1) oncogene of Epstein-Barr virus can simultaneously induce and inhibit apoptosis in B cells. Journal of virology. vol 86. issue 8. 2012-06-18. PMID:22318153. |
the expression of the mrna of bcl2a1, encoding an antiapoptotic homolog of bcl2, correlated directly with the expression of lmp1 in ebv-positive b-cell strains, and its expression inhibited the apoptosis induced by the transmembrane domains of lmp1. |
2012-06-18 |
2023-08-12 |
human |