| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jayant S Londhe, Thomas P A Devasagayam, L Yeap Foo, Padma Shastry, Saroj S Ghaskadb. Geraniin and amariin, ellagitannins from Phyllanthus amarus, protect liver cells against ethanol induced cytotoxicity. Fitoterapia. vol 83. issue 8. 2013-05-22. PMID:22982332. |
poly (adp-ribose) polymerase (parp), bax and bcl2 were checked to assess the induction of apoptosis using western blots. |
2013-05-22 |
2023-08-12 |
mouse |
| Paramasivan Poornima, Robin Sheeba Quency, Viswandha Vijaya Padm. Neferine induces reactive oxygen species mediated intrinsic pathway of apoptosis in HepG2 cells. Food chemistry. vol 136. issue 2. 2013-05-21. PMID:23122111. |
our data further indicate reduction of Δψm and increased [ca(2+)](i) during apoptosis induction by neferine with increased expression of apoptotic proteins such as bax, bad, cleaved forms of caspase 3, caspase 9 and parp, with the downregulation of anti-apoptotic protein bcl2 in hepg2 cells. |
2013-05-21 |
2023-08-12 |
Not clear |
| Chia-Hua Chou, Ching-Chih Lin, Ming-Chang Yang, Chih-Chang Wei, Huei-De Liao, Run-Chin Lin, Wen-Yu Tu, Tsung-Chieh Kao, Ching-Mei Hsu, Jiin-Tsuey Cheng, An-Kuo Chou, Chu-I Lee, Joon-Khim Loh, Shen-Long Howng, Yi-Ren Hon. GSK3beta-mediated Drp1 phosphorylation induced elongated mitochondrial morphology against oxidative stress. PloS one. vol 7. issue 11. 2013-05-14. PMID:23185298. |
in investigating the biofunctionality of phosphorylation sites within the ged domain, cells overexpressing drp1 s693d and s637d, but not s693a, showed an acquired resistance to h(2)o(2)-induced mitochondrial fragmentation and ensuing apoptosis, which affected cytochrome c, capase-3, -7, and parp, but not lc3b, atg-5, beclin-1 and bcl2 expressions. |
2013-05-14 |
2023-08-12 |
Not clear |
| Jake Shortt, Ricky W Johnston. Oncogenes in cell survival and cell death. Cold Spring Harbor perspectives in biology. vol 4. issue 12. 2013-05-13. PMID:23209150. |
therefore, cooperating genetic or epigenetic effects to suppress apoptosis (e.g., overexpression of bcl2) are required to enable the dual transforming processes of unbridled cell proliferation and robust suppression of apoptosis. |
2013-05-13 |
2023-08-12 |
Not clear |
| Elżbieta Płuciennik, Magdalena Nowakowska, Wioletta I Wujcicka, Anna Sitkiewicz, Bernarda Kazanowska, Elżbieta Zielińska, Andrzej K Bednare. Genetic alterations of WWOX in Wilms' tumor are involved in its carcinogenesis. Oncology reports. vol 28. issue 4. 2013-05-09. PMID:22842668. |
we evaluated the correlation between expression of wwox and genes involved in proliferation (ki67), apoptosis (bcl2, bax), signal transduction (erbb4, erbb2, egfr), cell cycle (ccne1, ccnd1), cell adhesion (cdh1) and transcription (tp73) using real-time rt-pcr in 23 tumor samples. |
2013-05-09 |
2023-08-12 |
Not clear |
| Xiaojia Guo, John C Schmitz, Barton C Kenney, Edward M Uchio, Sanjay Kulkarni, Charles H Ch. Intermedin is overexpressed in hepatocellular carcinoma and regulates cell proliferation and survival. Cancer science. vol 103. issue 8. 2013-05-07. PMID:22625651. |
blockage of imd signaling using either an antagonist peptide or a neutralizing antibody inhibited growth in a dose-dependent manner with concomitant induction of apoptosis, causing cleavage of caspase-8 and downregulation of gli1 and bcl2. |
2013-05-07 |
2023-08-12 |
human |
| Qing Li, Gang Wang, Jie Zhang, Ping Zhou, Tian-Yang Wang, Wei Cui, Ming-Jiu Luo, Jing-He Ta. Combined inhibitory effects of pyruvate and low temperature on postovulatory aging of mouse oocytes. Biology of reproduction. vol 87. issue 5. 2013-04-22. PMID:22954795. |
oocytes with impaired developmental potential after culture at 15°c for 96 h and at 5°c for 48 h showed unrecoverable decreases in the content of glutathione, the glutathione/oxidized glutathione ratio, the bcl2 content, and in the numbers of oocytes with normal spindles and cortical granule distribution, suggesting induction of oxidative stress, which caused oocyte apoptosis and cytoskeleton alterations by downregulating bcl2. |
2013-04-22 |
2023-08-12 |
mouse |
| Serkan Durdu, Gunseli C Deniz, Deniz Balci, Cagin Zaim, Arin Dogan, Alp Can, Kamil C Akcali, Ahmet Ruchan Aka. Apoptotic vascular smooth muscle cell depletion via BCL2 family of proteins in human ascending aortic aneurysm and dissection. Cardiovascular therapeutics. vol 30. issue 6. 2013-04-22. PMID:22978789. |
this study investigates the expression patterns of bcl2 (b-cell cll/lymphoma2) family of proteins and the extent of vascular smooth muscle cell (vsmc) apoptosis in thoracic aortic aneurysms (taa), type-a aortic dissections (tad), and nondilated ascending aortic samples. |
2013-04-22 |
2023-08-12 |
human |
| Sankaranarayanan Kannan, Robert M Sutphin, Mandy G Hall, Leonard S Golfman, Wendy Fang, Riitta M Nolo, Lauren J Akers, Richard A Hammitt, John S McMurray, Steven M Kornblau, Ari M Melnick, Maria E Figueroa, Patrick A Zweidler-McKa. Notch activation inhibits AML growth and survival: a potential therapeutic approach. The Journal of experimental medicine. vol 210. issue 2. 2013-04-12. PMID:23359069. |
induced activation through any of the notch receptors (notch1-4), or through the notch target hairy/enhancer of split 1 (hes1), consistently leads to aml growth arrest and caspase-dependent apoptosis, which are associated with b cell lymphoma 2 (bcl2) loss and enhanced p53/p21 expression. |
2013-04-12 |
2023-08-12 |
human |
| Feiran Gong, Luan Sun, Yujie Su. A novel SATB1 binding site in the BCL2 promoter region possesses transcriptional regulatory function. Journal of biomedical research. vol 24. issue 6. 2013-04-05. PMID:23554662. |
bcl2 is a key regulator of apoptosis. |
2013-04-05 |
2023-08-12 |
Not clear |
| Chun-Yan Sun, Xiao-Mei She, You Qin, Zhang-Bo Chu, Lei Chen, Li-Sha Ai, Lu Zhang, Yu H. miR-15a and miR-16 affect the angiogenesis of multiple myeloma by targeting VEGF. Carcinogenesis. vol 34. issue 2. 2013-04-03. PMID:23104180. |
two mirnas, mir-15a and mir-16, which act as putative tumor suppressor by targeting the oncogene bcl2, have been implicated in cell cycle, apoptosis and proliferation. |
2013-04-03 |
2023-08-12 |
mouse |
| Andreas U Lindner, Caoimhín G Concannon, Gerhardt J Boukes, Mary D Cannon, Fabien Llambi, Deborah Ryan, Karen Boland, Joan Kehoe, Deborah A McNamara, Frank Murray, Elaine W Kay, Suzanne Hector, Douglas R Green, Heinrich J Huber, Jochen H M Preh. Systems analysis of BCL2 protein family interactions establishes a model to predict responses to chemotherapy. Cancer research. vol 73. issue 2. 2013-03-26. PMID:23329644. |
here, we report findings from a systems study of the intrinsic pathway of apoptosis by bcl2 family proteins and clinical translation of its findings into a model with applications in colorectal cancer (crc). |
2013-03-26 |
2023-08-12 |
Not clear |
| Annamaria Spina, Francesca Di Maiolo, Antonietta Esposito, Luigi Sapio, Emilio Chiosi, Luca Sorvillo, Silvio Navigli. cAMP Elevation Down-Regulates β3 Integrin and Focal Adhesion Kinase and Inhibits Leptin-Induced Migration of MDA-MB-231 Breast Cancer Cells. BioResearch open access. vol 1. issue 6. 2013-03-22. PMID:23515360. |
very surprisingly, this provided evidence that when camp levels are increased, leptin drives cells towards apoptosis associated with a marked decrease of bcl2 protein levels and accompanied by down-regulation of protein kinase a (pka). |
2013-03-22 |
2023-08-12 |
Not clear |
| Arindam P Ghosh, Barbara J Klocke, Mary E Ballestas, Kevin A Rot. CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress. PloS one. vol 7. issue 6. 2013-03-21. PMID:22761832. |
puma (p53 upregulated modulator of apoptosis) and bim (bcl2 interacting mediator of cell death), pro-apoptotic bh3 domain-only, bcl2 family members, have previously been shown to regulate er stress-induced cell death, but the upstream signaling pathways that regulate this response in neuronal cells are incompletely defined. |
2013-03-21 |
2023-08-12 |
Not clear |
| Rodrigo N Lamounier, Cassio N Coimbra, Peter White, Flavia L Costal, Leonardo S Oliveira, Daniel Giannella-Neto, Klaus H Kaestner, Maria Lúcia Corrêa-Giannell. Apoptosis rate and transcriptional response of pancreatic islets exposed to the PPAR gamma agonist Pioglitazone. Diabetology & metabolic syndrome. vol 5. issue 1. 2013-03-19. PMID:23298687. |
at 5.6 mm glucose, pioglitazone elicited a transient reduction in islets apoptosis rate while at 23 mm, bcl2 expression was reduced and apoptosis rate was increased by pioglitazone. |
2013-03-19 |
2023-08-12 |
rat |
| Debangshu Samanta, Jacob Kaufman, David P Carbone, Pran K Datt. Long-term smoking mediated down-regulation of Smad3 induces resistance to carboplatin in non-small cell lung cancer. Neoplasia (New York, N.Y.). vol 14. issue 7. 2013-03-18. PMID:22904681. |
the increase in ic(50) and decrease in apoptosis in long-term csc-treated cells is correlated with the expression of bcl2. |
2013-03-18 |
2023-08-12 |
human |
| V V Kolobov, Z I Storozheva, M A Gruden, V V Sherstne. Regional features of the expression of genes involved in neurogenesis and apoptosis in the brain of adult rats. Bulletin of experimental biology and medicine. vol 153. issue 5. 2013-03-12. PMID:23113275. |
the expression of mrna of genes involved in neurogenesis and apoptosis (apaf1, ascl1, bax, bcl2, casp3, casp8, casp9, dffb, myh10, naip2, napa, notch2, numb, pura, s100a6, tnf) in the prefrontal cortex, hippocampus, and cerebellum was studied in adult rats. |
2013-03-12 |
2023-08-12 |
rat |
| Tal Koppelmann, Yulia Pollak, Jorge Mogilner, Jacob Bejar, Arnold G Coran, Igor Sukhotni. Reversal of severe methotrexate-induced intestinal damage using enteral n-3 fatty acids. The British journal of nutrition. vol 109. issue 1. 2013-02-26. PMID:22456439. |
a significant decrease in enterocyte apoptosis in the ileum of mtx-n-3 pufa rats (v. mtx) was accompanied by decreased bax mrna and protein expression and increased bcl2 mrna levels. |
2013-02-26 |
2023-08-12 |
rat |
| Richa Singh, Neeru Sain. Downregulation of BCL2 by miRNAs augments drug-induced apoptosis--a combined computational and experimental approach. Journal of cell science. vol 125. issue Pt 6. 2013-02-11. PMID:22328513. |
downregulation of bcl2 by mirnas augments drug-induced apoptosis--a combined computational and experimental approach. |
2013-02-11 |
2023-08-12 |
human |
| Nicole Suyun Liu, Xiaoli Du, Jia Lu, Bei Ping H. Diva reduces cell death in response to oxidative stress and cytotoxicity. PloS one. vol 7. issue 8. 2013-02-11. PMID:22905226. |
diva is a member of the bcl2 family but its function in apoptosis remains largely unclear because of its specific expression found within limited adult tissues. |
2013-02-11 |
2023-08-12 |
rat |