| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andreas U Lindner, Caoimhín G Concannon, Gerhardt J Boukes, Mary D Cannon, Fabien Llambi, Deborah Ryan, Karen Boland, Joan Kehoe, Deborah A McNamara, Frank Murray, Elaine W Kay, Suzanne Hector, Douglas R Green, Heinrich J Huber, Jochen H M Preh. Systems analysis of BCL2 protein family interactions establishes a model to predict responses to chemotherapy. Cancer research. vol 73. issue 2. 2013-03-26. PMID:23329644. |
here, we report findings from a systems study of the intrinsic pathway of apoptosis by bcl2 family proteins and clinical translation of its findings into a model with applications in colorectal cancer (crc). |
2013-03-26 |
2023-08-12 |
Not clear |
| Annamaria Spina, Francesca Di Maiolo, Antonietta Esposito, Luigi Sapio, Emilio Chiosi, Luca Sorvillo, Silvio Navigli. cAMP Elevation Down-Regulates β3 Integrin and Focal Adhesion Kinase and Inhibits Leptin-Induced Migration of MDA-MB-231 Breast Cancer Cells. BioResearch open access. vol 1. issue 6. 2013-03-22. PMID:23515360. |
very surprisingly, this provided evidence that when camp levels are increased, leptin drives cells towards apoptosis associated with a marked decrease of bcl2 protein levels and accompanied by down-regulation of protein kinase a (pka). |
2013-03-22 |
2023-08-12 |
Not clear |
| Arindam P Ghosh, Barbara J Klocke, Mary E Ballestas, Kevin A Rot. CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress. PloS one. vol 7. issue 6. 2013-03-21. PMID:22761832. |
puma (p53 upregulated modulator of apoptosis) and bim (bcl2 interacting mediator of cell death), pro-apoptotic bh3 domain-only, bcl2 family members, have previously been shown to regulate er stress-induced cell death, but the upstream signaling pathways that regulate this response in neuronal cells are incompletely defined. |
2013-03-21 |
2023-08-12 |
Not clear |
| Rodrigo N Lamounier, Cassio N Coimbra, Peter White, Flavia L Costal, Leonardo S Oliveira, Daniel Giannella-Neto, Klaus H Kaestner, Maria Lúcia Corrêa-Giannell. Apoptosis rate and transcriptional response of pancreatic islets exposed to the PPAR gamma agonist Pioglitazone. Diabetology & metabolic syndrome. vol 5. issue 1. 2013-03-19. PMID:23298687. |
at 5.6 mm glucose, pioglitazone elicited a transient reduction in islets apoptosis rate while at 23 mm, bcl2 expression was reduced and apoptosis rate was increased by pioglitazone. |
2013-03-19 |
2023-08-12 |
rat |
| Debangshu Samanta, Jacob Kaufman, David P Carbone, Pran K Datt. Long-term smoking mediated down-regulation of Smad3 induces resistance to carboplatin in non-small cell lung cancer. Neoplasia (New York, N.Y.). vol 14. issue 7. 2013-03-18. PMID:22904681. |
the increase in ic(50) and decrease in apoptosis in long-term csc-treated cells is correlated with the expression of bcl2. |
2013-03-18 |
2023-08-12 |
human |
| V V Kolobov, Z I Storozheva, M A Gruden, V V Sherstne. Regional features of the expression of genes involved in neurogenesis and apoptosis in the brain of adult rats. Bulletin of experimental biology and medicine. vol 153. issue 5. 2013-03-12. PMID:23113275. |
the expression of mrna of genes involved in neurogenesis and apoptosis (apaf1, ascl1, bax, bcl2, casp3, casp8, casp9, dffb, myh10, naip2, napa, notch2, numb, pura, s100a6, tnf) in the prefrontal cortex, hippocampus, and cerebellum was studied in adult rats. |
2013-03-12 |
2023-08-12 |
rat |
| Tal Koppelmann, Yulia Pollak, Jorge Mogilner, Jacob Bejar, Arnold G Coran, Igor Sukhotni. Reversal of severe methotrexate-induced intestinal damage using enteral n-3 fatty acids. The British journal of nutrition. vol 109. issue 1. 2013-02-26. PMID:22456439. |
a significant decrease in enterocyte apoptosis in the ileum of mtx-n-3 pufa rats (v. mtx) was accompanied by decreased bax mrna and protein expression and increased bcl2 mrna levels. |
2013-02-26 |
2023-08-12 |
rat |
| Richa Singh, Neeru Sain. Downregulation of BCL2 by miRNAs augments drug-induced apoptosis--a combined computational and experimental approach. Journal of cell science. vol 125. issue Pt 6. 2013-02-11. PMID:22328513. |
downregulation of bcl2 by mirnas augments drug-induced apoptosis--a combined computational and experimental approach. |
2013-02-11 |
2023-08-12 |
human |
| Nicole Suyun Liu, Xiaoli Du, Jia Lu, Bei Ping H. Diva reduces cell death in response to oxidative stress and cytotoxicity. PloS one. vol 7. issue 8. 2013-02-11. PMID:22905226. |
diva is a member of the bcl2 family but its function in apoptosis remains largely unclear because of its specific expression found within limited adult tissues. |
2013-02-11 |
2023-08-12 |
rat |
| Nicole Suyun Liu, Xiaoli Du, Jia Lu, Bei Ping H. Diva reduces cell death in response to oxidative stress and cytotoxicity. PloS one. vol 7. issue 8. 2013-02-11. PMID:22905226. |
in addition, immunoprecipitation studies also noted a decrease in diva's interaction with bcl2 and bax following apoptosis induced by oxidative stress. |
2013-02-11 |
2023-08-12 |
rat |
| Ryoung-Hoon Jeon, Geun-Ho Maeng, Won-Jae Lee, Tae-Ho Kim, Yeon-Mi Lee, Jeong-Hyeon Lee, Basavarajappa-Mohana Kumar, Sung-Lim Lee, Gyu-Jin Rh. Removal of cumulus cells before oocyte nuclear maturation enhances enucleation rates without affecting the developmental competence of porcine cloned embryos. The Japanese journal of veterinary research. vol 60. issue 4. 2013-02-07. PMID:23304980. |
following scnt and parthenogenesis (pa) using pre-denuded group and control group oocytes, no significant (p>0.05) differences were observed with respect to the development, total cell number, incidence of apoptosis and the expression profile of developmentally important genes (pou5f1, dnmt1, dnmt3a, igf2r, bax, bcl2 and glut1) at the blastocyst stage. |
2013-02-07 |
2023-08-12 |
Not clear |
| Abdel Rahman Zekri, Hydi Ahmed, Medhat Ismail, Afaf T El-Nashar, Tamer El-Mokadem, Ahmed Hassa. Genetic profiling of non-Hodgkin's lymphoma with or without hepatitis C virus infection. The Egyptian journal of immunology. vol 17. issue 2. 2013-01-31. PMID:23082489. |
we found that hcv may rescue b lymphocytes from apoptosis possibly through causing suppression of casp1 and casp4 and causing overexpression of the anti-apoptotic bcl2 gene. |
2013-01-31 |
2023-08-12 |
Not clear |
| Doreen Kunze, Kati Erdmann, Michael Froehner, Manfred P Wirth, Susanne Fuesse. siRNA-mediated inhibition of antiapoptotic genes enhances chemotherapy efficacy in bladder cancer cells. Anticancer research. vol 32. issue 10. 2013-01-14. PMID:23060552. |
the up-regulation of antiapoptotic b-cell cll/lymphoma 2 (bcl2), bcl2-like 1 (bclxl), x-linked inhibitor of apoptosis (xiap) and survivin is one mechanism by which cancer cells develop resistance towards chemotherapeutics. |
2013-01-14 |
2023-08-12 |
Not clear |
| Mitali Pandey, Parminder Kaur, Sanjeev Shukla, Ata Abbas, Pingfu Fu, Sanjay Gupt. Plant flavone apigenin inhibits HDAC and remodels chromatin to induce growth arrest and apoptosis in human prostate cancer cells: in vitro and in vivo study. Molecular carcinogenesis. vol 51. issue 12. 2012-12-26. PMID:22006862. |
furthermore, apigenin intake caused a significant decrease in bcl2 expression with concomitant increase in bax, shifting the bax/bcl2 ratio in favor of apoptosis. |
2012-12-26 |
2023-08-12 |
mouse |
| Fieke Lamers, Linda Schild, Ilona J M den Hartog, Marli E Ebus, Ellen M Westerhout, Ingrid Ora, Jan Koster, Rogier Versteeg, Huib N Caron, Jan J Molenaa. Targeted BCL2 inhibition effectively inhibits neuroblastoma tumour growth. European journal of cancer (Oxford, England : 1990). vol 48. issue 16. 2012-12-21. PMID:22366560. |
silencing of bcl2 in kcnr and sjnb12 resulted in massive apoptosis, while cell lines with low bcl2 expression were insensitive. |
2012-12-21 |
2023-08-12 |
mouse |
| Fangmei An, Bangdong Gong, Hui Wang, Dongshan Yu, Gangde Zhao, Lanyi Lin, Weiliang Tang, Hong Yu, Shisan Bao, Qing Xi. miR-15b and miR-16 regulate TNF mediated hepatocyte apoptosis via BCL2 in acute liver failure. Apoptosis : an international journal on programmed cell death. vol 17. issue 7. 2012-12-21. PMID:22374434. |
mir-15b and mir-16 regulate tnf mediated hepatocyte apoptosis via bcl2 in acute liver failure. |
2012-12-21 |
2023-08-12 |
Not clear |
| Fangmei An, Bangdong Gong, Hui Wang, Dongshan Yu, Gangde Zhao, Lanyi Lin, Weiliang Tang, Hong Yu, Shisan Bao, Qing Xi. miR-15b and miR-16 regulate TNF mediated hepatocyte apoptosis via BCL2 in acute liver failure. Apoptosis : an international journal on programmed cell death. vol 17. issue 7. 2012-12-21. PMID:22374434. |
among the up-regulated mirnas involved in apoptosis, mir-15b and mir-16 showed the highest enrichment and targeted the common anti-apoptotic gene, bcl2. |
2012-12-21 |
2023-08-12 |
Not clear |
| Fangmei An, Bangdong Gong, Hui Wang, Dongshan Yu, Gangde Zhao, Lanyi Lin, Weiliang Tang, Hong Yu, Shisan Bao, Qing Xi. miR-15b and miR-16 regulate TNF mediated hepatocyte apoptosis via BCL2 in acute liver failure. Apoptosis : an international journal on programmed cell death. vol 17. issue 7. 2012-12-21. PMID:22374434. |
these data suggest that mir-15b and mir-16 regulate tnf mediated hepatic apoptosis via bcl2 during alf, and may shed light on the development of a therapeutic strategy for treatment of alf. |
2012-12-21 |
2023-08-12 |
Not clear |
| Mary F Otterson, Linghui Nie, Jamie L Schmidt, Benjamin J Link, Nebojsa Jovanovic, Orestis Lyros, Parvaneh Rafie. EUK-207 protects human intestinal microvascular endothelial cells (HIMEC) against irradiation-induced apoptosis through the Bcl2 pathway. Life sciences. vol 91. issue 15-16. 2012-12-19. PMID:22940617. |
euk-207 protects human intestinal microvascular endothelial cells (himec) against irradiation-induced apoptosis through the bcl2 pathway. |
2012-12-19 |
2023-08-12 |
human |
| Christopher I Slape, Jesslyn Saw, Jeremy B M Jowett, Peter D Aplan, Andreas Strasser, Stephen M Jane, David J Curti. Inhibition of apoptosis by BCL2 prevents leukemic transformation of a murine myelodysplastic syndrome. Blood. vol 120. issue 12. 2012-12-18. PMID:22855610. |
inhibition of apoptosis by bcl2 prevents leukemic transformation of a murine myelodysplastic syndrome. |
2012-12-18 |
2023-08-12 |
mouse |