| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hongfu Xie, Fangfen Liu, Leishan Liu, Jian Dan, Ying Luo, Yuxin Yi, Xiang Chen, Ji L. Protective role of AQP3 in UVA-induced NHSFs apoptosis via Bcl2 up-regulation. Archives of dermatological research. vol 305. issue 5. 2013-10-21. PMID:23463292. |
protective role of aqp3 in uva-induced nhsfs apoptosis via bcl2 up-regulation. |
2013-10-21 |
2023-08-12 |
human |
| Xiaoming Yang, Yali Xu, Fenghua Guo, Yanxia Ning, Xiuling Zhi, Lianhua Yin, Xiaobo L. Hydroxysteroid sulfotransferase SULT2B1b promotes hepatocellular carcinoma cells proliferation in vitro and in vivo. PloS one. vol 8. issue 4. 2013-10-17. PMID:23593328. |
likewise, inhibition of sult2b1b expression induced cell-cycle arrest and apoptosis in hepa1-6 cells by upregulating the expression of fas, downregulating the expression of cyclinb1, bcl2 and myc in vitro and in vivo at both the transcript and protein levels. |
2013-10-17 |
2023-08-12 |
mouse |
| Nancy C Reic. A death-promoting role for ISG54/IFIT2. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. vol 33. issue 4. 2013-09-30. PMID:23570386. |
expression of this protein has been found to promote cellular apoptosis by a mitochondrial pathway dependent on the action of bcl2 proteins. |
2013-09-30 |
2023-08-12 |
Not clear |
| Ming-Hui Zou, Zhonglin Xi. Regulation of interplay between autophagy and apoptosis in the diabetic heart: new role of AMPK. Autophagy. vol 9. issue 4. 2013-09-24. PMID:23380689. |
activation of ampk directly phosphorylates mapk8, which mediates bcl2 phosphorylation and subsequent becn1-bcl2 dissociation, leading to restoration of cardiac autophagy, protection against cardiac apoptosis, and ultimately improvement in cardiac structure and function. |
2013-09-24 |
2023-08-12 |
Not clear |
| Ming-Hui Zou, Zhonglin Xi. Regulation of interplay between autophagy and apoptosis in the diabetic heart: new role of AMPK. Autophagy. vol 9. issue 4. 2013-09-24. PMID:23380689. |
we conclude that dissociation of bcl2 from becn1 through activation of mapk8-bcl2 signaling may be an important mechanism by which ampk activation restores autophagy, protects against cardiac apoptosis, and prevents diabetic cardiomyopathy. |
2013-09-24 |
2023-08-12 |
Not clear |
| Jesus A F Tresguerres, Roman Kireev, Katherine Forman, Sara Cuesta, Ana F Tresguerres, Elena Var. Effect of chronic melatonin administration on several physiological parameters from old Wistar rats and SAMP8 mice. Current aging science. vol 5. issue 3. 2013-09-24. PMID:23387890. |
after treatment, the expression of inflammatory mediators (tumor necrosis factor-α, interleukin 1 and 10, nfκbp50 and nfκbp52), apoptosis markers (bad, bax, and bcl2), and parameters related to oxidative stress (heme oxygenases 1 and 2, endothelial and inducible nitric oxide synthases) were determined in the heart. |
2013-09-24 |
2023-08-12 |
mouse |
| Yunhua Zhu, Yi-Fu Huang, Calvina Kek, Dmitry V Bulavi. Apoptosis differently affects lineage tracing of Lgr5 and Bmi1 intestinal stem cell populations. Cell stem cell. vol 12. issue 3. 2013-09-05. PMID:23415913. |
in turn, when we suppressed apoptosis by either bcl2 overexpression or chk2 deletion, we found that lineage tracing of lgr5-positive cells was efficiently reduced. |
2013-09-05 |
2023-08-12 |
mouse |
| B Hernaez, M Cabezas, R Muñoz-Moreno, I Galindo, M A Cuesta-Geijo, C Alons. A179L, a new viral Bcl2 homolog targeting Beclin 1 autophagy related protein. Current molecular medicine. vol 13. issue 2. 2013-09-04. PMID:23228131. |
a179l, the viral bcl2 homolog of african swine fever virus, interacts with proapoptotic bcl2 family proteins to inhibit apoptosis. |
2013-09-04 |
2023-08-12 |
Not clear |
| Hoyun Choi, Hanna Lee, Sae Rom Kim, Yong Song Gho, Suk Kyeong Le. Epstein-Barr virus-encoded microRNA BART15-3p promotes cell apoptosis partially by targeting BRUCE. Journal of virology. vol 87. issue 14. 2013-09-04. PMID:23678170. |
using bioinformatic analyses, we predicted that mir-bart15-3p may target the antiapoptotic b-cell lymphoma 2 (bcl2), bcl2l2, dead (asp-glu-ala-asp) box polypeptide 42 (ddx42), and baculovirus inhibitor of apoptosis repeat-containing ubiquitin-conjugating enzyme (bruce) mrnas. |
2013-09-04 |
2023-08-12 |
Not clear |
| J T Lynch, T D D Somerville, G J Spencer, X Huang, T C P Somervaill. TTC5 is required to prevent apoptosis of acute myeloid leukemia stem cells. Cell death & disease. vol 4. 2013-08-23. PMID:23559008. |
consistent with the physical interaction of ttc5 and ep300, the onset of apoptosis following kd of either gene was preceded by reduced expression of bcl2 and increased expression of pro-apoptotic genes. |
2013-08-23 |
2023-08-12 |
human |
| J T Lynch, T D D Somerville, G J Spencer, X Huang, T C P Somervaill. TTC5 is required to prevent apoptosis of acute myeloid leukemia stem cells. Cell death & disease. vol 4. 2013-08-23. PMID:23559008. |
forced expression of bcl2 blocked apoptosis and partially rescued the clonogenic potential of aml cells following ttc5 kd. |
2013-08-23 |
2023-08-12 |
human |
| Roman Kireev, Samuel Bitoun, Sara Cuesta, Alejandro Tejerina, Carolina Ibarrola, Enrique Moreno, Elena Vara, Jesus A F Tresguerre. Melatonin treatment protects liver of Zucker rats after ischemia/reperfusion by diminishing oxidative stress and apoptosis. European journal of pharmacology. vol 701. issue 1-3. 2013-08-22. PMID:23220161. |
the expression of inos, enos, bcl2, bax, bad and aif were determined by rt-pcr melatonin was effective at decreasing liver injury by both ways as assessed by liver transaminases, markers of apoptosis, of oxidative stress and improved liver atp content. |
2013-08-22 |
2023-08-12 |
rat |
| Maryam Bannazadeh Amirkhiz, Nadereh Rashtchizadeh, Hossein Nazemiyeh, Jalal Abdolalizadeh, Leila Mohammadnejad, Behzad Baradara. Investigating Apoptotic Effects of Methanolic Extract of Dorema glabrum Seed on WEHI-164 Cells. ISRN pharmacology. vol 2013. 2013-08-19. PMID:23956872. |
induction of apoptosis by the plant extract was proved by the reduction of pro-caspase-3 and bcl2 proteins and increase in caspase-3 gene expression and decrease in that of bcl2 too. |
2013-08-19 |
2023-08-12 |
Not clear |
| Alessio Papi, Fulvia Farabegoli, Renato Iori, Marina Orlandi, Gina R De Nicola, Manuela Bagatta, Donato Angelino, Lorenzo Gennari, Paolino Ninfal. Vitexin-2-O-xyloside, raphasatin and (-)-epigallocatechin-3-gallate synergistically affect cell growth and apoptosis of colon cancer cells. Food chemistry. vol 138. issue 2-3. 2013-08-16. PMID:23411276. |
further analysis revealed a g0/g1 arrest of the phase cell progression and apoptosis, linked to modulation of bax, bcl2, caspase-9 and poly(adp-ribose) polymerase as well as reactive oxygen species (ros) generation in both colon cancer cells, whereas apoptosis and ros were not significantly detected in normal human lymphocytes. |
2013-08-16 |
2023-08-12 |
human |
| Alexander Widiapradja, Viktor Vegh, Ker Zhing Lok, Silvia Manzanero, John Thundyil, Mathias Gelderblom, Yi-Lin Cheng, Dale Pavlovski, Sung-Chun Tang, Dong-Gyu Jo, Tim Magnus, Sic L Chan, Christopher G Sobey, David Reutens, Milan Basta, Mark P Mattson, Thiruma V Arumuga. Intravenous immunoglobulin protects neurons against amyloid beta-peptide toxicity and ischemic stroke by attenuating multiple cell death pathways. Journal of neurochemistry. vol 122. issue 2. 2013-08-14. PMID:22494053. |
together, these results indicate that ivig acts directly on neurons to protect them against ischemic stroke and aβ-induced neuronal apoptosis by inhibiting cell death pathways and by elevating levels of the anti-apoptotic protein bcl2. |
2013-08-14 |
2023-08-12 |
mouse |
| Beata Pyrzynska, Magdalena Banach-Orlowska, Marta Teperek-Tkacz, Katarzyna Miekus, Grazyna Drabik, Marcin Majka, Marta Miaczynsk. Multifunctional protein APPL2 contributes to survival of human glioma cells. Molecular oncology. vol 7. issue 1. 2013-08-08. PMID:22989406. |
instead, we attribute the reduced cell survival upon appl2 depletion to the changes in gene expression, in particular to the upregulation of apoptosis-related genes, such as unc5b (a proapoptotic dependence receptor) and hrk (harakiri, an activator of apoptosis, which antagonizes anti-apoptotic function of bcl2). |
2013-08-08 |
2023-08-12 |
human |
| Dorothée Selimoglu-Buet, Isabelle Gallais, Nicole Denis, Christel Guillouf, Françoise Moreau-Gacheli. Oncogenic kit triggers Shp2/Erk1/2 pathway to down-regulate the pro-apoptotic protein Bim and to promote apoptosis resistance in leukemic cells. PloS one. vol 7. issue 11. 2013-07-24. PMID:23145067. |
we reported here that bim(el), a pro-apoptotic member of the bcl2 family proteins, is the target of erk1/2 signaling and that its down-regulation is responsible for the apoptosis resistance of murine and human leukemic cells. |
2013-07-24 |
2023-08-12 |
human |
| Hiroko Shigemi, Takahiro Yamauchi, Yukie Tanaka, Takanori Ued. Novel leukemic cell lines resistant to clofarabine by mechanisms of decreased active metabolite and increased antiapoptosis. Cancer science. vol 104. issue 6. 2013-07-18. PMID:23421409. |
in addition, the two variants were resistant to cafda-induced apoptosis due to bcl2 overexpression and decreased bim. |
2013-07-18 |
2023-08-12 |
human |
| Shouqing Luo, David C Rubinsztei. BCL2L11/BIM: a novel molecular link between autophagy and apoptosis. Autophagy. vol 9. issue 1. 2013-07-15. PMID:23064249. |
in response to toxic stimuli, bcl2l11 (also known as bim), a bh3-only protein, is released from its interaction with dynein light chain 1 (dynll1 also known as lc8) and can induce apoptosis by inactivating anti-apoptotic bcl2 proteins and by activating bax-bak1. |
2013-07-15 |
2023-08-12 |
Not clear |
| Manisha Gupta, Michael K Lo, Christina F Spiropoulo. Activation and cell death in human dendritic cells infected with Nipah virus. Virology. vol 441. issue 1. 2013-07-12. PMID:23587249. |
also have reduced levels of bcl2 and high levels of active caspase 3, suggesting the induction of apoptosis. |
2013-07-12 |
2023-08-12 |
human |