| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Roman Kireev, Samuel Bitoun, Sara Cuesta, Alejandro Tejerina, Carolina Ibarrola, Enrique Moreno, Elena Vara, Jesus A F Tresguerre. Melatonin treatment protects liver of Zucker rats after ischemia/reperfusion by diminishing oxidative stress and apoptosis. European journal of pharmacology. vol 701. issue 1-3. 2013-08-22. PMID:23220161. |
the expression of inos, enos, bcl2, bax, bad and aif were determined by rt-pcr melatonin was effective at decreasing liver injury by both ways as assessed by liver transaminases, markers of apoptosis, of oxidative stress and improved liver atp content. |
2013-08-22 |
2023-08-12 |
rat |
| Maryam Bannazadeh Amirkhiz, Nadereh Rashtchizadeh, Hossein Nazemiyeh, Jalal Abdolalizadeh, Leila Mohammadnejad, Behzad Baradara. Investigating Apoptotic Effects of Methanolic Extract of Dorema glabrum Seed on WEHI-164 Cells. ISRN pharmacology. vol 2013. 2013-08-19. PMID:23956872. |
induction of apoptosis by the plant extract was proved by the reduction of pro-caspase-3 and bcl2 proteins and increase in caspase-3 gene expression and decrease in that of bcl2 too. |
2013-08-19 |
2023-08-12 |
Not clear |
| Alessio Papi, Fulvia Farabegoli, Renato Iori, Marina Orlandi, Gina R De Nicola, Manuela Bagatta, Donato Angelino, Lorenzo Gennari, Paolino Ninfal. Vitexin-2-O-xyloside, raphasatin and (-)-epigallocatechin-3-gallate synergistically affect cell growth and apoptosis of colon cancer cells. Food chemistry. vol 138. issue 2-3. 2013-08-16. PMID:23411276. |
further analysis revealed a g0/g1 arrest of the phase cell progression and apoptosis, linked to modulation of bax, bcl2, caspase-9 and poly(adp-ribose) polymerase as well as reactive oxygen species (ros) generation in both colon cancer cells, whereas apoptosis and ros were not significantly detected in normal human lymphocytes. |
2013-08-16 |
2023-08-12 |
human |
| Alexander Widiapradja, Viktor Vegh, Ker Zhing Lok, Silvia Manzanero, John Thundyil, Mathias Gelderblom, Yi-Lin Cheng, Dale Pavlovski, Sung-Chun Tang, Dong-Gyu Jo, Tim Magnus, Sic L Chan, Christopher G Sobey, David Reutens, Milan Basta, Mark P Mattson, Thiruma V Arumuga. Intravenous immunoglobulin protects neurons against amyloid beta-peptide toxicity and ischemic stroke by attenuating multiple cell death pathways. Journal of neurochemistry. vol 122. issue 2. 2013-08-14. PMID:22494053. |
together, these results indicate that ivig acts directly on neurons to protect them against ischemic stroke and aβ-induced neuronal apoptosis by inhibiting cell death pathways and by elevating levels of the anti-apoptotic protein bcl2. |
2013-08-14 |
2023-08-12 |
mouse |
| Beata Pyrzynska, Magdalena Banach-Orlowska, Marta Teperek-Tkacz, Katarzyna Miekus, Grazyna Drabik, Marcin Majka, Marta Miaczynsk. Multifunctional protein APPL2 contributes to survival of human glioma cells. Molecular oncology. vol 7. issue 1. 2013-08-08. PMID:22989406. |
instead, we attribute the reduced cell survival upon appl2 depletion to the changes in gene expression, in particular to the upregulation of apoptosis-related genes, such as unc5b (a proapoptotic dependence receptor) and hrk (harakiri, an activator of apoptosis, which antagonizes anti-apoptotic function of bcl2). |
2013-08-08 |
2023-08-12 |
human |
| Dorothée Selimoglu-Buet, Isabelle Gallais, Nicole Denis, Christel Guillouf, Françoise Moreau-Gacheli. Oncogenic kit triggers Shp2/Erk1/2 pathway to down-regulate the pro-apoptotic protein Bim and to promote apoptosis resistance in leukemic cells. PloS one. vol 7. issue 11. 2013-07-24. PMID:23145067. |
we reported here that bim(el), a pro-apoptotic member of the bcl2 family proteins, is the target of erk1/2 signaling and that its down-regulation is responsible for the apoptosis resistance of murine and human leukemic cells. |
2013-07-24 |
2023-08-12 |
human |
| Hiroko Shigemi, Takahiro Yamauchi, Yukie Tanaka, Takanori Ued. Novel leukemic cell lines resistant to clofarabine by mechanisms of decreased active metabolite and increased antiapoptosis. Cancer science. vol 104. issue 6. 2013-07-18. PMID:23421409. |
in addition, the two variants were resistant to cafda-induced apoptosis due to bcl2 overexpression and decreased bim. |
2013-07-18 |
2023-08-12 |
human |
| Shouqing Luo, David C Rubinsztei. BCL2L11/BIM: a novel molecular link between autophagy and apoptosis. Autophagy. vol 9. issue 1. 2013-07-15. PMID:23064249. |
in response to toxic stimuli, bcl2l11 (also known as bim), a bh3-only protein, is released from its interaction with dynein light chain 1 (dynll1 also known as lc8) and can induce apoptosis by inactivating anti-apoptotic bcl2 proteins and by activating bax-bak1. |
2013-07-15 |
2023-08-12 |
Not clear |
| Manisha Gupta, Michael K Lo, Christina F Spiropoulo. Activation and cell death in human dendritic cells infected with Nipah virus. Virology. vol 441. issue 1. 2013-07-12. PMID:23587249. |
also have reduced levels of bcl2 and high levels of active caspase 3, suggesting the induction of apoptosis. |
2013-07-12 |
2023-08-12 |
human |
| Rósula García-Navas, Markus Munder, Faustino Mollined. Depletion of L-arginine induces autophagy as a cytoprotective response to endoplasmic reticulum stress in human T lymphocytes. Autophagy. vol 8. issue 11. 2013-07-10. PMID:22874569. |
silencing of ern1 (ire1α) prevented the induction of autophagy as well as mapk8 activation, bcl2 phosphorylation and xbp1 splicing, whereas led t lymphocytes to apoptosis under l-arg starvation, suggesting that the ern1-mapk8 pathway plays a major role in the activation of autophagy following l-arg depletion. |
2013-07-10 |
2023-08-12 |
human |
| Young Mi Whang, Ukhyun Jo, Jae Sook Sung, Hyun Jung Ju, Hyun Kyung Kim, Kyong Hwa Park, Jong Won Lee, In Song Koh, Yeul Hong Ki. Wnt5a is associated with cigarette smoke-related lung carcinogenesis via protein kinase C. PloS one. vol 8. issue 1. 2013-07-09. PMID:23349696. |
this reduced cell survival rate was associated with increased apoptosis via the down-regulation of bcl2 and the induction of cleaved poly adp-ribose polymerase. |
2013-07-09 |
2023-08-12 |
human |
| Kranthi Kunkalla, Yadong Liu, Changju Qu, Vasiliki Leventaki, Nitin K Agarwal, Rajesh R Singh, Francisco Veg. Functional inhibition of BCL2 is needed to increase the susceptibility to apoptosis to SMO inhibitors in diffuse large B-cell lymphoma of germinal center subtype. Annals of hematology. vol 92. issue 6. 2013-07-09. PMID:23370596. |
functional inhibition of bcl2 is needed to increase the susceptibility to apoptosis to smo inhibitors in diffuse large b-cell lymphoma of germinal center subtype. |
2013-07-09 |
2023-08-12 |
Not clear |
| Kranthi Kunkalla, Yadong Liu, Changju Qu, Vasiliki Leventaki, Nitin K Agarwal, Rajesh R Singh, Francisco Veg. Functional inhibition of BCL2 is needed to increase the susceptibility to apoptosis to SMO inhibitors in diffuse large B-cell lymphoma of germinal center subtype. Annals of hematology. vol 92. issue 6. 2013-07-09. PMID:23370596. |
we concluded that in gc dlbcl cell lines, in contrast to those of abc type, functional inhibition of bcl2 family members is usually needed to overcome the resistance to apoptosis to smo inhibitors. |
2013-07-09 |
2023-08-12 |
Not clear |
| Songyu Cao, Cheng Wang, Xinen Huang, Juncheng Dai, Lingmin Hu, Yao Liu, Jiaping Chen, Hongxia Ma, Guangfu Jin, Zhibin Hu, Lin Xu, Hongbing She. Prognostic assessment of apoptotic gene polymorphisms in non-small cell lung cancer in Chinese. Journal of biomedical research. vol 27. issue 3. 2013-07-04. PMID:23720679. |
to test this hypothesis, we selected 38 potentially functional single nucleotide polymorphisms (snps) from 12 genes (bax, bcl2, bid, casp3, casp6, casp7, casp8, casp9, casp10, fas, faslg and mcl1) involved in apoptosis to assess their prognostic significance in lung cancer in a chinese case cohort with 568 non-small cell lung cancer (nsclc) patients. |
2013-07-04 |
2023-08-12 |
Not clear |
| Robert R Zielinski, Bernhard J Eigl, Kim N Ch. Targeting the apoptosis pathway in prostate cancer. Cancer journal (Sudbury, Mass.). vol 19. issue 1. 2013-07-03. PMID:23337761. |
we review the current status of agents that intervene at the bcl2 checkpoints, humanized antibodies to death receptors, agents that target the inhibitors of apoptosis proteins, mimetics of small mitochondria-derived activator of caspases, and antisense therapies targeting cytoprotective chaperones. |
2013-07-03 |
2023-08-12 |
Not clear |
| Yuanxiang Jin, Xiuhong Pan, Limin Cao, Bufang Ma, Zhengwei F. Embryonic exposure to cis-bifenthrin enantioselectively induces the transcription of genes related to oxidative stress, apoptosis and immunotoxicity in zebrafish (Danio rerio). Fish & shellfish immunology. vol 34. issue 2. 2013-07-01. PMID:23261506. |
we observed that the mrna levels of the most genes related to oxidative stress, apoptosis and immunotoxicity including cu/zn-superoxide dismutase (cu/zn-sod), catalase (cat), p53, murine double minute 2 (mdm2), b-cell lymphoma/leukaemia-2 gene (bcl2), bcl2 associated x protein (bax), apoptotic protease activating factor-1 (apaf1), caspase 9 (cas9), caspase 3 (cas3), interleukin-1 beta (il-1β) and interleukin-8(il-8) were much higher in 1s-cis-bf treated group than those in cis-bf or 1r-cis-bf treated ones, suggesting that 1s-cis-bf has higher risk to induced oxidative stress, apoptosis and immunotoxicity than 1r-cis-bf in zebrafish. |
2013-07-01 |
2023-08-12 |
cat |
| Casandra M Cartagena, Kara E Schmid, Katie L Phillips, Frank C Tortella, Jitendra R Dav. Changes in apoptotic mechanisms following penetrating ballistic-like brain injury. Journal of molecular neuroscience : MN. vol 49. issue 2. 2013-06-27. PMID:22684621. |
for the mitochondria-mediated apoptosis pathway, rqs of anti-apoptotic factors bcl2a1d and birc3 were upregulated while both bcl2 and bax were downregulated. |
2013-06-27 |
2023-08-12 |
Not clear |
| Hyun-Jin Nam, Seock-Ah Im, Do-Youn Oh, Paul Elvin, Hwang-Phill Kim, Young-Kwang Yoon, Ahrum Min, Sang-Hyun Song, Sae-Won Han, Tae-You Kim, Yung-Jue Ban. Antitumor activity of saracatinib (AZD0530), a c-Src/Abl kinase inhibitor, alone or in combination with chemotherapeutic agents in gastric cancer. Molecular cancer therapeutics. vol 12. issue 1. 2013-06-27. PMID:23144237. |
apoptosis required induction of the proapoptotic bcl2 family member bim. |
2013-06-27 |
2023-08-12 |
human |
| Alexander Arlt, Susanne Sebens Müerköster, Heiner Schäfe. Targeting apoptosis pathways in pancreatic cancer. Cancer letters. vol 332. issue 2. 2013-06-24. PMID:21078544. |
thus, pdac cells exhibit alterations in the egfr/mapk/ras/raf1-, pi3k/akt-, trail/traf2-, or ikk/nf-κb pathway accompanied by deregulations in the expression of apoptosis regulators such as ciap, bcl2, xiap or survivin. |
2013-06-24 |
2023-08-12 |
Not clear |
| Behnam Kamalidehghan, Fatemeh Ahmadipour, Mohamed Ibrahim Noordi. DNA fragmentation is not associated with apoptosis in zerumbone-induced HepG2 cells. Iranian biomedical journal. vol 16. issue 4. 2013-06-21. PMID:23183623. |
to furthur confirm the induction of apoptosis, the protein of zerumbone-induced hepg2 cells using western-blotting indicated a low and high expression of bcl2 and bax proteins, respectively. |
2013-06-21 |
2023-08-12 |
human |